SIMILAR PATTERNS OF AMINO ACIDS FOR 4L4C_B_CAMB502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avq LAMBDA EXONUCLEASE

(Escherichia
virus Lambda) 		PF09588
(YqaJ) 		4 TYR A 107
LEU A  27
VAL A  14
ILE A   5
 None
 1.00A 4l4cB-1avqA:
undetectable		 4l4cB-1avqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)
PROTEIN (CARDOSIN A)

(Cynara
cardunculus;
Cynara
cardunculus) 		PF00026
(Asp)
PF00026
(Asp) 		4 PHE A 213
TYR A 189
ASP A 215
ILE B 300
 None
 0.93A 4l4cB-1b5fA:
0.0		 4l4cB-1b5fA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		4 PHE A 291
LEU A 405
VAL A 272
ILE A 294
 None
 0.84A 4l4cB-1cjyA:
0.0		 4l4cB-1cjyA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp2 ISOFLAVONE
O-METHYLTRANSFERASE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 PHE A 186
THR A 285
LEU A 347
ILE A 206
 None
 0.99A 4l4cB-1fp2A:
0.0		 4l4cB-1fp2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 LEU A 448
VAL A 438
ASP A 428
ILE A 426
 None
 0.86A 4l4cB-1m2wA:
0.0		 4l4cB-1m2wA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A 831
LEU A 847
VAL A 850
ILE A 875
 None
 0.93A 4l4cB-1nd7A:
0.0		 4l4cB-1nd7A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwg (2R)-PHOSPHO-3-SULFO
LACTATE SYNTHASE

(Methanocaldococcus
jannaschii) 		PF02679
(ComA) 		4 PHE A 219
LEU A 178
VAL A 197
ILE A 199
 None
 0.86A 4l4cB-1qwgA:
0.0		 4l4cB-1qwgA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 THR A 421
VAL A 427
VAL A 311
ILE A 326
 None
 1.00A 4l4cB-1sqjA:
0.0		 4l4cB-1sqjA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ss4 GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF13669
(Glyoxalase_4) 		4 PHE A  26
VAL A  16
VAL A  12
ILE A  69
 None
 0.96A 4l4cB-1ss4A:
undetectable		 4l4cB-1ss4A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		4 PHE A 148
VAL A 205
VAL A 155
ILE A 152
 None
 0.93A 4l4cB-1t8qA:
undetectable		 4l4cB-1t8qA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyd TYROSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		4 THR E 258
LEU E 298
VAL E 302
ILE E  46
 None
 0.99A 4l4cB-1tydE:
undetectable		 4l4cB-1tydE:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.00A 4l4cB-1wytA:
undetectable		 4l4cB-1wytA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xat XENOBIOTIC
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00132
(Hexapep) 		4 THR A 111
VAL A 143
VAL A 117
ILE A 119
 None
 1.01A 4l4cB-1xatA:
undetectable		 4l4cB-1xatA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc3 PUTATIVE
FRUCTOKINASE

(Bacillus
subtilis) 		PF00480
(ROK) 		4 PHE A  86
VAL A  41
VAL A  98
ILE A  55
 None
 0.92A 4l4cB-1xc3A:
undetectable		 4l4cB-1xc3A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
furiosus) 		PF01470
(Peptidase_C15) 		4 LEU A  26
VAL A   5
VAL A 167
ILE A 165
 None
 0.97A 4l4cB-1z8wA:
undetectable		 4l4cB-1z8wA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		4 LEU A  28
VAL A  45
VAL A 104
ILE A  55
 None
 0.92A 4l4cB-2a0uA:
undetectable		 4l4cB-2a0uA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctf VIGILIN

(Homo sapiens) 		PF00013
(KH_1) 		4 PHE A  63
LEU A  72
VAL A  90
ILE A  41
 None
 0.92A 4l4cB-2ctfA:
undetectable		 4l4cB-2ctfA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE

(Sulfurisphaera
tokodaii) 		no annotation 4 LEU A 103
VAL A  99
VAL A 188
ILE A 177
 None
 0.92A 4l4cB-2dgdA:
undetectable		 4l4cB-2dgdA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ery RAS-RELATED PROTEIN
R-RAS2

(Homo sapiens) 		PF00071
(Ras) 		4 LEU A  30
VAL A 164
ASP A 130
ILE A 160
 None
None
GDP  A   1 (-3.0A)
None
 0.96A 4l4cB-2eryA:
undetectable		 4l4cB-2eryA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		4 THR A 250
LEU A 191
VAL A 187
ILE A  51
 None
 0.92A 4l4cB-2gsnA:
undetectable		 4l4cB-2gsnA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1

(Anopheles
gambiae) 		PF00481
(PP2C) 		4 LEU A 197
VAL A 307
VAL A 323
ILE A 361
 None
 0.94A 4l4cB-2irmA:
undetectable		 4l4cB-2irmA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Methanothermobacter
thermautotrophicus) 		PF01641
(SelR) 		4 PHE A  90
LEU A 123
VAL A 114
VAL A  94
 None
 1.00A 4l4cB-2k8dA:
undetectable		 4l4cB-2k8dA:
17.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 PHE A  87
TYR A  96
LEU A 244
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
None
 0.75A 4l4cB-2m56A:
68.8		 4l4cB-2m56A:
99.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		8 PHE A  87
TYR A  96
THR A 101
LEU A 244
VAL A 247
VAL A 295
ASP A 297
ILE A 395
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
 0.37A 4l4cB-2m56A:
68.8		 4l4cB-2m56A:
99.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m83 PROTEIN PHOSPHATASE
1 REGULATORY SUBUNIT
3A

(Oryctolagus
cuniculus) 		PF03370
(CBM_21) 		4 THR A 135
LEU A 231
VAL A 207
VAL A 161
 None
 0.93A 4l4cB-2m83A:
undetectable		 4l4cB-2m83A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Caldanaerobacter
subterraneus) 		PF03009
(GDPD) 		4 LEU A  55
VAL A  47
VAL A 147
ILE A 149
 None
 0.86A 4l4cB-2pz0A:
undetectable		 4l4cB-2pz0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyf MAD2L1-BINDING
PROTEIN

(Homo sapiens) 		PF06581
(p31comet) 		4 LEU B 135
VAL B 134
VAL B 150
ILE B 152
 None
 0.86A 4l4cB-2qyfB:
undetectable		 4l4cB-2qyfB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8r SENSOR PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF02702
(KdpD) 		4 THR A 204
LEU A   8
VAL A 121
ASP A 147
 None
 0.89A 4l4cB-2r8rA:
undetectable		 4l4cB-2r8rA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		4 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.96A 4l4cB-2wsmA:
undetectable		 4l4cB-2wsmA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		4 THR A  93
LEU A  90
VAL A  60
ASP A  78
 None
 0.99A 4l4cB-2ymuA:
undetectable		 4l4cB-2ymuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		4 THR A 298
LEU A 295
VAL A 265
ASP A 283
 None
 0.98A 4l4cB-2ymuA:
undetectable		 4l4cB-2ymuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		4 THR A 544
LEU A 541
VAL A 511
ASP A 529
 None
 1.01A 4l4cB-2ymuA:
undetectable		 4l4cB-2ymuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aux DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Methanocaldococcus
jannaschii) 		PF13476
(AAA_23) 		4 THR A 949
LEU A 982
VAL A 985
ILE A 963
 MG  A1050 (-3.0A)
None
None
None
 0.91A 4l4cB-3auxA:
undetectable		 4l4cB-3auxA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bex TYPE III
PANTOTHENATE KINASE

(Thermotoga
maritima) 		PF03309
(Pan_kinase) 		4 THR A 130
VAL A 192
VAL A 168
ILE A 220
 None
 0.97A 4l4cB-3bexA:
undetectable		 4l4cB-3bexA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 THR A1189
LEU A1186
VAL A1153
ASP A1173
 None
 1.00A 4l4cB-3dm0A:
undetectable		 4l4cB-3dm0A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j83 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A 270
VAL A 212
VAL A  32
ILE A  34
 None
 0.80A 4l4cB-3j83A:
undetectable		 4l4cB-3j83A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2i ACYL-COENZYME A
THIOESTERASE 4

(Homo sapiens) 		PF04775
(Bile_Hydr_Trans)
PF08840
(BAAT_C) 		4 PHE A 208
TYR A 207
LEU A 196
ILE A 237
 None
 0.97A 4l4cB-3k2iA:
undetectable		 4l4cB-3k2iA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 CUBILIN

(Homo sapiens) 		PF00431
(CUB) 		4 PHE B 974
LEU B1022
VAL B 992
ILE B1009
 None
 0.86A 4l4cB-3kq4B:
undetectable		 4l4cB-3kq4B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krm INSULIN-LIKE GROWTH
FACTOR 2
MRNA-BINDING PROTEIN
1

(Homo sapiens) 		PF00013
(KH_1) 		4 LEU A 513
VAL A 521
VAL A 494
ILE A 492
 None
 0.78A 4l4cB-3krmA:
undetectable		 4l4cB-3krmA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l06 N-ACETYLORNITHINE
CARBAMOYLTRANSFERASE

(Xanthomonas
campestris) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 PHE A  81
VAL A 111
VAL A  98
ILE A  95
 None
 0.75A 4l4cB-3l06A:
undetectable		 4l4cB-3l06A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld2 PUTATIVE
ACETYLTRANSFERASE

(Streptococcus
mutans) 		PF00583
(Acetyltransf_1) 		4 PHE A  79
LEU A 129
VAL A 115
ILE A 113
 None
 0.90A 4l4cB-3ld2A:
undetectable		 4l4cB-3ld2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okx YAEB-LIKE PROTEIN
RPA0152

(Rhodopseudomonas
palustris) 		PF01980
(UPF0066) 		4 LEU A 139
VAL A  55
VAL A 118
ILE A  66
 None
 0.99A 4l4cB-3okxA:
undetectable		 4l4cB-3okxA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on9 TUMOUR NECROSIS
FACTOR RECEPTOR

(Ectromelia
virus) 		PF07190
(DUF1406) 		4 THR A 303
LEU A 255
VAL A 270
ILE A 170
 None
 1.01A 4l4cB-3on9A:
undetectable		 4l4cB-3on9A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 4 THR B 191
LEU B 252
VAL B 250
VAL B 236
 None
None
None
FAD  B 405 (-3.6A)
 0.92A 4l4cB-3ozvB:
undetectable		 4l4cB-3ozvB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvz UDP-N-ACETYLGLUCOSAM
INE 4,6-DEHYDRATASE

(Aliivibrio
fischeri) 		PF02719
(Polysacc_synt_2) 		4 THR A 145
LEU A  38
VAL A  63
ASP A 101
 None
 0.96A 4l4cB-3pvzA:
undetectable		 4l4cB-3pvzA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		4 THR A  71
LEU A 152
VAL A 150
VAL A 103
 None
 0.95A 4l4cB-3skvA:
undetectable		 4l4cB-3skvA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umf ADENYLATE KINASE

(Schistosoma
mansoni) 		PF00406
(ADK) 		4 PHE A  13
TYR A  96
LEU A  74
VAL A 110
 None
 0.84A 4l4cB-3umfA:
undetectable		 4l4cB-3umfA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vor CFA/III PILIN

(Escherichia
coli) 		PF05946
(TcpA) 		4 THR A 169
LEU A 150
VAL A 120
ILE A 109
 None
 0.84A 4l4cB-3vorA:
undetectable		 4l4cB-3vorA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wia NITRITE REDUCTASE

(Geobacillus
kaustophilus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A  73
VAL A 151
VAL A 278
ILE A 232
 None
 0.96A 4l4cB-3wiaA:
undetectable		 4l4cB-3wiaA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkq NITRITE REDUCTASE

(Geobacillus
thermodenitrificans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A  73
VAL A 151
VAL A 278
ILE A 232
 MPD  A 419 ( 4.7A)
None
None
None
 0.94A 4l4cB-3wkqA:
undetectable		 4l4cB-3wkqA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 PHE A 369
LEU A 299
VAL A 337
ILE A 341
 None
 0.87A 4l4cB-4a2qA:
undetectable		 4l4cB-4a2qA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bps FKBO

(Streptomyces
hygroscopicus) 		no annotation 4 PHE A 123
THR A 137
VAL A 225
ILE A 171
 None
 0.94A 4l4cB-4bpsA:
undetectable		 4l4cB-4bpsA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0r PUTATIVE AMINO ACID
BINDING PROTEIN

(Streptococcus
mutans) 		PF00497
(SBP_bac_3) 		4 PHE A 196
LEU A 211
VAL A  35
ILE A  65
 None
 1.01A 4l4cB-4c0rA:
undetectable		 4l4cB-4c0rA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB

(Bacillus
subtilis) 		PF01471
(PG_binding_1)
PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		4 PHE A 230
LEU A 318
VAL A 299
ILE A 217
 None
 0.96A 4l4cB-4c2fA:
undetectable		 4l4cB-4c2fA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		6 TYR A  98
THR A 103
LEU A 252
VAL A 303
ASP A 305
ILE A 403
 None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
None
 0.65A 4l4cB-4c9mA:
58.7		 4l4cB-4c9mA:
45.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 TYR A  98
THR A 103
LEU A 252
VAL A 404
 None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
GOL  A1419 (-3.5A)
 0.82A 4l4cB-4c9mA:
58.7		 4l4cB-4c9mA:
45.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6v G PROTEIN BETA
SUBUNIT GIB2

(Cryptococcus
neoformans) 		PF00400
(WD40) 		4 THR A 187
LEU A 184
VAL A 151
ASP A 171
 None
 0.95A 4l4cB-4d6vA:
undetectable		 4l4cB-4d6vA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		4 THR A 114
LEU A 267
VAL A 270
ILE A 237
 None
 0.94A 4l4cB-4eqmA:
undetectable		 4l4cB-4eqmA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev1 ANABENA TIC22

(Anabaena sp.) 		PF04278
(Tic22) 		4 PHE A 136
LEU A 122
VAL A 113
ILE A  46
 NHE  A 303 (-4.4A)
None
None
None
 1.00A 4l4cB-4ev1A:
undetectable		 4l4cB-4ev1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		4 THR A 463
VAL A 443
VAL A 338
ILE A 342
 None
 0.92A 4l4cB-4fajA:
undetectable		 4l4cB-4fajA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxh PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Xenorhabdus
bovienii) 		PF01470
(Peptidase_C15) 		4 LEU A  27
VAL A   6
VAL A 168
ILE A 166
 None
 0.98A 4l4cB-4gxhA:
undetectable		 4l4cB-4gxhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcy THIAMINASE-I

(Naegleria
gruberi) 		no annotation 4 THR A 253
LEU A 163
VAL A 152
ILE A 147
 None
 0.88A 4l4cB-4hcyA:
undetectable		 4l4cB-4hcyA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		4 LEU A 323
VAL A 345
ASP A 383
ILE A   4
 None
 0.93A 4l4cB-4hpvA:
undetectable		 4l4cB-4hpvA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 4 PHE A 132
TYR A  78
LEU A 209
ILE A 133
 None
EGR  A 501 (-4.5A)
None
None
 0.89A 4l4cB-4j0kA:
undetectable		 4l4cB-4j0kA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljs PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 LEU A 295
VAL A 300
VAL A 218
ILE A 216
 None
 0.89A 4l4cB-4ljsA:
undetectable		 4l4cB-4ljsA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puf E3 UBIQUITIN-PROTEIN
LIGASE SLRP

(Salmonella
enterica) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		4 PHE A 663
LEU A 673
VAL A 756
ILE A 579
 None
 0.83A 4l4cB-4pufA:
undetectable		 4l4cB-4pufA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		4 LEU A 278
VAL A 348
ASP A 321
ILE A 261
 None
 0.86A 4l4cB-4pxqA:
undetectable		 4l4cB-4pxqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1z PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF16215
(DUF4876) 		4 PHE A 224
TYR A 256
THR A 258
ILE A 197
 None
 0.88A 4l4cB-4q1zA:
undetectable		 4l4cB-4q1zA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 PHE B 473
THR B 503
LEU B 449
VAL B 445
 None
 1.01A 4l4cB-4q4aB:
undetectable		 4l4cB-4q4aB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		4 LEU A 370
VAL A 100
ASP A 459
ILE A 461
 None
 0.90A 4l4cB-4qfhA:
undetectable		 4l4cB-4qfhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 LEU A 613
VAL A 487
VAL A 576
ILE A 578
 None
 0.91A 4l4cB-4rf7A:
undetectable		 4l4cB-4rf7A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 TYR A 555
THR A 491
VAL A 540
ILE A 542
 None
 0.78A 4l4cB-4rsoA:
undetectable		 4l4cB-4rsoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txd CSC2

(Thermofilum
pendens) 		no annotation 4 THR A  85
LEU A 249
VAL A 264
VAL A  39
 None
 0.96A 4l4cB-4txdA:
undetectable		 4l4cB-4txdA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7o TYPE VI SECRETION
SYSTEM PROTEIN VASD

(Escherichia
coli) 		PF12790
(T6SS-SciN) 		4 THR C 107
LEU C  26
VAL C  86
ILE C  30
 None
 0.97A 4l4cB-4y7oC:
undetectable		 4l4cB-4y7oC:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		4 PHE A1139
LEU A1639
VAL A1146
ILE A1143
 None
 0.93A 4l4cB-4yknA:
undetectable		 4l4cB-4yknA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8t AVRRXO1-ORF1

(Xanthomonas
oryzae) 		no annotation 4 THR A 184
LEU A 142
VAL A 243
VAL A 194
 None
 0.79A 4l4cB-4z8tA:
undetectable		 4l4cB-4z8tA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3u L-SERINE
AMMONIA-LYASE

(Rhizomucor
miehei) 		PF00291
(PALP) 		4 LEU A  92
VAL A  94
VAL A 144
ILE A 142
 None
 0.79A 4l4cB-5c3uA:
undetectable		 4l4cB-5c3uA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		4 PHE A 264
LEU A 364
VAL A 253
ILE A  61
 None
None
None
FAD  A 500 (-4.8A)
 0.99A 4l4cB-5fjnA:
undetectable		 4l4cB-5fjnA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 LEU A 315
VAL A 361
VAL A 305
ILE A 302
 None
 1.01A 4l4cB-5gr1A:
undetectable		 4l4cB-5gr1A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 4 THR A 551
LEU A 557
VAL A 560
ILE A 610
 None
 0.94A 4l4cB-5h7jA:
undetectable		 4l4cB-5h7jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn1 INTERLEUKIN-37

(Homo sapiens) 		PF00340
(IL1) 		4 PHE A  91
LEU A 133
VAL A 187
ILE A  62
 None
 1.01A 4l4cB-5hn1A:
undetectable		 4l4cB-5hn1A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 PHE A3675
LEU A3664
VAL A3635
ILE A3677
 None
 0.97A 4l4cB-5nugA:
undetectable		 4l4cB-5nugA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B
HETERODISULFIDE
REDUCTASE, SUBUNIT C

(Methanothermococcus
thermolithotrophicus;
Methanothermococcus
thermolithotrophicus) 		PF02754
(CCG)
PF13183
(Fer4_8) 		4 THR C  50
LEU B 207
VAL B 200
ASP C  73
 None
 0.97A 4l4cB-5odrC:
undetectable		 4l4cB-5odrC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufq R11.1.6

(Sulfolobus
solfataricus) 		no annotation 4 LEU C  58
VAL C  22
VAL C   3
ILE C  16
 None
 1.01A 4l4cB-5ufqC:
undetectable		 4l4cB-5ufqC:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqi PHOSPHOSUGAR
ISOMERASE

(Escherichia
coli) 		no annotation 5 PHE A  48
THR A  70
LEU A 172
VAL A 168
ILE A  95
 None
 1.45A 4l4cB-5uqiA:
undetectable		 4l4cB-5uqiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqj U6 SNRNA
PHOSPHODIESTERASE

(Saccharomyces
cerevisiae) 		PF09749
(HVSL) 		4 PHE A 204
LEU A 169
VAL A 273
ILE A 164
 None
None
ACT  A 307 (-4.1A)
None
 1.01A 4l4cB-5uqjA:
undetectable		 4l4cB-5uqjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7c ACYLOXYACYL
HYDROLASE

(Homo sapiens) 		no annotation 4 LEU A 111
VAL A 107
VAL A  62
ILE A  51
 None
 0.96A 4l4cB-5w7cA:
undetectable		 4l4cB-5w7cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 4 LEU A 110
VAL A 106
VAL A  61
ILE A  50
 None
 0.99A 4l4cB-5w7dA:
undetectable		 4l4cB-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2g CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Campylobacter
jejuni) 		no annotation 4 PHE A   7
TYR A 459
THR A 651
LEU A 435
 None
 1.00A 4l4cB-5x2gA:
undetectable		 4l4cB-5x2gA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 376
VAL A 379
VAL A 281
ILE A 306
 None
None
GOL  A 402 (-4.0A)
None
 0.87A 4l4cB-5x5hA:
undetectable		 4l4cB-5x5hA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 4 PHE A 139
LEU A 639
VAL A 146
ILE A 143
 None
 0.93A 4l4cB-5xgjA:
undetectable		 4l4cB-5xgjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvd HYDROGENASE-2 SMALL
CHAIN

(Citrobacter sp.
MGH106) 		no annotation 4 PHE S 161
LEU S  47
VAL S  14
ILE S 115
 None
 0.93A 4l4cB-5xvdS:
undetectable		 4l4cB-5xvdS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4j XYLOSE ISOMERASE

(Streptomyces
rubiginosus) 		PF01261
(AP_endonuc_2) 		4 PHE A 162
THR A 119
LEU A  93
ILE A 180
 None
 0.99A 4l4cB-5y4jA:
undetectable		 4l4cB-5y4jA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybw ASPARTATE RACEMASE

(Scapharca
broughtonii) 		no annotation 4 THR A 303
VAL A 214
VAL A 316
ILE A 318
 None
 0.80A 4l4cB-5ybwA:
undetectable		 4l4cB-5ybwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb9 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Salmonella
enterica) 		no annotation 4 PHE A  57
THR A  62
VAL A  81
ILE A  83
 None
 0.99A 4l4cB-6bb9A:
undetectable		 4l4cB-6bb9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 4 TYR A 227
THR A 358
VAL A 208
ILE A 238
 None
 0.98A 4l4cB-6bz0A:
undetectable		 4l4cB-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT C''
V0 ASSEMBLY PROTEIN
1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 LEU C 157
VAL C  73
VAL N 239
ILE N 236
 None
 0.84A 4l4cB-6c6lC:
undetectable		 4l4cB-6c6lC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en9 HYDROGENASE-2 SMALL
CHAIN

(Escherichia
coli) 		no annotation 4 PHE S 161
LEU S  47
VAL S  14
ILE S 115
 None
 0.94A 4l4cB-6en9S:
undetectable		 4l4cB-6en9S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)

(Homo sapiens) 		no annotation 4 THR A 416
LEU A 187
VAL A 235
ILE A 231
 None
 1.00A 4l4cB-6gctA:
undetectable		 4l4cB-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 4 THR A 805
LEU A 761
VAL A 760
VAL A 676
 None
 0.99A 4l4cB-6gh2A:
undetectable		 4l4cB-6gh2A:
undetectable