SIMILAR PATTERNS OF AMINO ACIDS FOR 4L4B_A_CAMA502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 LEU A 623
VAL A 626
VAL A 661
VAL A 638
 None
 0.93A 4l4bA-1c30A:
0.0		 4l4bA-1c30A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5c RAB6 GTPASE

(Plasmodium
falciparum) 		PF00071
(Ras) 		4 THR A 168
LEU A  14
VAL A 122
VAL A  90
 None
 1.02A 4l4bA-1d5cA:
0.0		 4l4bA-1d5cA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exh EXO-1,4-BETA-D-GLYCA
NASE

(Cellulomonas
fimi) 		PF00553
(CBM_2) 		4 PHE A  42
VAL A  25
VAL A  58
VAL A  67
 None
 1.05A 4l4bA-1exhA:
undetectable		 4l4bA-1exhA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8p MAGNESIUM-CHELATASE
38 KDA SUBUNIT

(Rhodobacter
capsulatus) 		PF01078
(Mg_chelatase) 		4 THR A  39
VAL A  62
VAL A 213
VAL A  50
 None
 0.91A 4l4bA-1g8pA:
0.0		 4l4bA-1g8pA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 THR A 247
LEU A 424
VAL A 427
VAL A 443
 None
MPD  A 802 ( 4.4A)
None
None
 0.92A 4l4bA-1kwgA:
0.0		 4l4bA-1kwgA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 THR A 396
LEU A 345
VAL A 257
VAL A 404
 None
 1.02A 4l4bA-1mb9A:
0.0		 4l4bA-1mb9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		4 THR A 312
VAL A 264
ASP A 320
VAL A 247
 None
 0.92A 4l4bA-1p1mA:
undetectable		 4l4bA-1p1mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 PHE X 493
LEU X 456
VAL X 560
VAL X 600
 None
 0.82A 4l4bA-1r6bX:
0.0		 4l4bA-1r6bX:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6t PUTATIVE PROTEIN

(Aquifex
aeolicus) 		PF01751
(Toprim) 		4 PHE 1  69
VAL 1  54
VAL 1  93
VAL 1  65
 None
 0.82A 4l4bA-1t6t1:
undetectable		 4l4bA-1t6t1:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		4 THR A 421
LEU A 325
VAL A 328
VAL A  64
 None
 0.91A 4l4bA-1v5cA:
0.2		 4l4bA-1v5cA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6h DIVALENT CATION
TOLERANCE PROTEIN
CUTA1

(Thermus
thermophilus) 		PF03091
(CutA1) 		4 LEU A  74
VAL A  71
VAL A  31
VAL A  57
 None
 1.03A 4l4bA-1v6hA:
undetectable		 4l4bA-1v6hA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9j BOLA-LIKE PROTEIN
RIKEN CDNA
1110025L05

(Mus musculus) 		PF01722
(BolA) 		4 LEU A  87
VAL A  83
VAL A  48
VAL A  66
 None
 0.59A 4l4bA-1v9jA:
undetectable		 4l4bA-1v9jA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vav ALGINATE LYASE
PA1167

(Pseudomonas
aeruginosa) 		PF08787
(Alginate_lyase2) 		4 LEU A 169
VAL A 164
VAL A 134
VAL A 117
 None
 1.01A 4l4bA-1vavA:
undetectable		 4l4bA-1vavA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxb PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE

(Streptomyces
coelicolor) 		PF01503
(PRA-PH) 		4 PHE A   6
LEU A  90
VAL A  86
VAL A  72
 None
 0.97A 4l4bA-1yxbA:
undetectable		 4l4bA-1yxbA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		4 TYR A  93
LEU A 150
VAL A 138
VAL A  81
 SAZ  A 709 (-4.9A)
None
None
None
 0.94A 4l4bA-1yyrA:
undetectable		 4l4bA-1yyrA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z47 PUTATIVE
ABC-TRANSPORTER
ATP-BINDING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 LEU A 168
VAL A  89
VAL A  72
VAL A  79
 None
 0.93A 4l4bA-1z47A:
undetectable		 4l4bA-1z47A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgz TORCAD OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
TORR

(Escherichia
coli) 		PF00072
(Response_reg) 		4 LEU A  49
VAL A 100
ASP A  98
VAL A  79
 None
 1.03A 4l4bA-1zgzA:
undetectable		 4l4bA-1zgzA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct8 METHIONYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.05A 4l4bA-2ct8A:
undetectable		 4l4bA-2ct8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dv6 NITRITE REDUCTASE

(Hyphomicrobium
denitrificans) 		PF07732
(Cu-oxidase_3) 		4 LEU A 131
VAL A 130
VAL A  27
VAL A  65
 None
 1.05A 4l4bA-2dv6A:
undetectable		 4l4bA-2dv6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		4 LEU A 331
VAL A 169
ASP A 140
VAL A 138
 None
None
None
FAD  A 500 (-4.0A)
 1.07A 4l4bA-2gv8A:
undetectable		 4l4bA-2gv8A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus) 		PF01707
(Peptidase_C9) 		4 PHE A 761
THR A 704
LEU A 700
VAL A 745
 None
 0.91A 4l4bA-2hwkA:
undetectable		 4l4bA-2hwkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		4 TYR A 138
LEU A 383
VAL A 159
VAL A 133
 None
None
None
FAD  A 501 (-3.9A)
 0.82A 4l4bA-2i0zA:
undetectable		 4l4bA-2i0zA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Methanothermobacter
thermautotrophicus) 		PF01641
(SelR) 		4 PHE A  90
LEU A 123
VAL A 114
VAL A  94
 None
 0.94A 4l4bA-2k8dA:
undetectable		 4l4bA-2k8dA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knb E3 UBIQUITIN-PROTEIN
LIGASE PARKIN

(Rattus
norvegicus) 		PF00240
(ubiquitin) 		4 THR A  21
VAL A  29
VAL A  67
VAL A   5
 None
 0.84A 4l4bA-2knbA:
undetectable		 4l4bA-2knbA:
11.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		8 PHE A  87
TYR A  96
THR A 101
LEU A 244
VAL A 247
VAL A 295
ASP A 297
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
 0.35A 4l4bA-2m56A:
68.2		 4l4bA-2m56A:
98.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m83 PROTEIN PHOSPHATASE
1 REGULATORY SUBUNIT
3A

(Oryctolagus
cuniculus) 		PF03370
(CBM_21) 		4 PHE A 192
THR A 135
LEU A 231
VAL A 207
 None
 1.02A 4l4bA-2m83A:
undetectable		 4l4bA-2m83A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m83 PROTEIN PHOSPHATASE
1 REGULATORY SUBUNIT
3A

(Oryctolagus
cuniculus) 		PF03370
(CBM_21) 		4 THR A 135
LEU A 231
VAL A 207
VAL A 161
 None
 0.92A 4l4bA-2m83A:
undetectable		 4l4bA-2m83A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgx UBIQUITIN-CONJUGATIN
G ENZYME E2 Q1

(Homo sapiens) 		PF00179
(UQ_con) 		4 PHE A  74
VAL A 122
VAL A  29
VAL A  41
 None
 0.58A 4l4bA-2qgxA:
undetectable		 4l4bA-2qgxA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		4 TYR A 444
LEU A 568
VAL A 392
VAL A 363
 None
 0.91A 4l4bA-2qzpA:
undetectable		 4l4bA-2qzpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8r SENSOR PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF02702
(KdpD) 		4 THR A 204
LEU A   8
VAL A   6
ASP A 147
 None
 1.03A 4l4bA-2r8rA:
undetectable		 4l4bA-2r8rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8r SENSOR PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF02702
(KdpD) 		4 THR A 204
LEU A   8
VAL A 121
ASP A 147
 None
 0.95A 4l4bA-2r8rA:
undetectable		 4l4bA-2r8rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 269
VAL A 293
VAL A  93
VAL A 134
 None
 0.93A 4l4bA-2v6bA:
undetectable		 4l4bA-2v6bA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		4 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.98A 4l4bA-2wsmA:
undetectable		 4l4bA-2wsmA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c41 AMINO ACID ABC
TRANSPORTER (ARTP)

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 LEU J 159
VAL J 190
VAL J   4
VAL J  22
 None
 0.98A 4l4bA-3c41J:
undetectable		 4l4bA-3c41J:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlt ESTERASE D

(Lactobacillus
rhamnosus) 		PF12146
(Hydrolase_4) 		4 THR A 222
VAL A 234
VAL A  45
VAL A  18
 None
 1.04A 4l4bA-3dltA:
undetectable		 4l4bA-3dltA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 THR A1170
LEU A1206
VAL A1209
VAL A1190
 None
 0.78A 4l4bA-3f2bA:
undetectable		 4l4bA-3f2bA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbc CHOLOYLGLYCINE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF02275
(CBAH) 		4 LEU A  32
VAL A  30
ASP A 171
VAL A 100
 None
 1.04A 4l4bA-3hbcA:
undetectable		 4l4bA-3hbcA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Nitrosospira
multiformis) 		PF00365
(PFK) 		4 LEU A 286
VAL A 282
VAL A 214
VAL A 243
 None
 0.67A 4l4bA-3hnoA:
undetectable		 4l4bA-3hnoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnr PROBABLE
METHYLTRANSFERASE
BT9727_4108

(Bacillus
thuringiensis) 		PF08241
(Methyltransf_11) 		4 LEU A  38
VAL A  41
VAL A  70
VAL A  49
 None
 0.86A 4l4bA-3hnrA:
undetectable		 4l4bA-3hnrA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		4 TYR A 156
VAL A  20
VAL A  98
VAL A 126
 None
 0.99A 4l4bA-3hvuA:
undetectable		 4l4bA-3hvuA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib6 UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		PF13419
(HAD_2) 		4 THR A  12
LEU A 140
VAL A   5
VAL A 117
 None
 0.64A 4l4bA-3ib6A:
undetectable		 4l4bA-3ib6A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1e CHAPERONIN BETA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		4 THR A 335
VAL A 297
VAL A 228
VAL A 368
 None
 0.98A 4l4bA-3j1eA:
undetectable		 4l4bA-3j1eA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 4 THR A 203
LEU A 349
VAL A 280
VAL A 134
 None
 0.95A 4l4bA-3j3iA:
undetectable		 4l4bA-3j3iA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orf DIHYDROPTERIDINE
REDUCTASE

(Dictyostelium
discoideum) 		PF00106
(adh_short) 		4 LEU A 193
VAL A 196
VAL A   7
VAL A  72
 None
 0.87A 4l4bA-3orfA:
undetectable		 4l4bA-3orfA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oxn PUTATIVE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio
parahaemolyticus) 		PF03466
(LysR_substrate) 		4 TYR A 291
THR A 123
VAL A 224
VAL A 190
 None
 0.88A 4l4bA-3oxnA:
undetectable		 4l4bA-3oxnA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 4 THR B 191
LEU B 252
VAL B 250
VAL B 236
 None
None
None
FAD  B 405 (-3.6A)
 1.05A 4l4bA-3ozvB:
undetectable		 4l4bA-3ozvB:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 PHE A1532
LEU A1511
VAL A1498
VAL A1489
 None
None
None
GOL  A   1 ( 4.7A)
 0.97A 4l4bA-3pvlA:
undetectable		 4l4bA-3pvlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9j SEPTUM
SITE-DETERMINING
PROTEIN MIND

(Escherichia
coli) 		PF01656
(CbiA) 		4 THR A 242
LEU A 179
VAL A 227
VAL A 217
 None
None
None
ADP  A 261 (-4.4A)
 1.07A 4l4bA-3r9jA:
undetectable		 4l4bA-3r9jA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rku OXIDOREDUCTASE
YMR226C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		4 LEU A  11
VAL A 151
ASP A 149
VAL A 100
 None
 0.78A 4l4bA-3rkuA:
undetectable		 4l4bA-3rkuA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		4 THR A  71
LEU A 152
VAL A 150
VAL A 103
 None
 0.92A 4l4bA-3skvA:
undetectable		 4l4bA-3skvA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		4 VAL A  14
VAL A  32
ASP A  34
VAL A   8
 FAD  A1001 (-3.9A)
None
FAD  A1001 (-2.6A)
None
 1.04A 4l4bA-3vqrA:
undetectable		 4l4bA-3vqrA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyr KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 2DL4

(Homo sapiens) 		PF00047
(ig) 		4 TYR A  72
LEU A  50
VAL A  18
VAL A  96
 None
 0.96A 4l4bA-3wyrA:
undetectable		 4l4bA-3wyrA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		4 THR A 513
LEU A 471
VAL A  40
VAL A  37
 None
 1.04A 4l4bA-4aahA:
undetectable		 4l4bA-4aahA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE

(Rhodococcus
rhodochrous) 		PF00743
(FMO-like) 		4 VAL A  27
VAL A 146
ASP A 144
VAL A 138
 None
 0.81A 4l4bA-4ap3A:
undetectable		 4l4bA-4ap3A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqq L2 PROTEIN III
(PENTON BASE)

(Human
mastadenovirus
B) 		PF01686
(Adeno_Penton_B) 		4 TYR A 376
LEU A 478
ASP A 214
VAL A 147
 None
 1.04A 4l4bA-4aqqA:
undetectable		 4l4bA-4aqqA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 THR A 377
LEU A 434
VAL A 405
VAL A 294
 None
 1.04A 4l4bA-4ay2A:
undetectable		 4l4bA-4ay2A:
21.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		6 TYR A  98
THR A 103
LEU A 252
VAL A 303
ASP A 305
VAL A 404
 None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
GOL  A1419 (-3.5A)
 0.52A 4l4bA-4c9mA:
58.7		 4l4bA-4c9mA:
45.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 TYR A  98
THR A 103
LEU A 252
VAL A 404
 None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
GOL  A1419 (-3.5A)
 0.75A 4l4bA-4c9mA:
58.7		 4l4bA-4c9mA:
45.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		4 LEU A 223
VAL A 136
ASP A 163
VAL A 165
 None
 1.02A 4l4bA-4cyfA:
undetectable		 4l4bA-4cyfA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6v G PROTEIN BETA
SUBUNIT GIB2

(Cryptococcus
neoformans) 		PF00400
(WD40) 		4 THR A 187
LEU A 184
VAL A 151
ASP A 171
 None
 1.04A 4l4bA-4d6vA:
undetectable		 4l4bA-4d6vA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		4 PHE A 159
THR A 177
VAL A 144
VAL A 267
 None
None
AW2  A 502 ( 4.9A)
AW2  A 502 (-4.8A)
 0.88A 4l4bA-4er6A:
undetectable		 4l4bA-4er6A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ese FMN-DEPENDENT
NADH-AZOREDUCTASE

(Yersinia pestis) 		PF02525
(Flavodoxin_2) 		4 LEU A 195
VAL A 198
VAL A   4
VAL A  89
 None
 0.73A 4l4bA-4eseA:
undetectable		 4l4bA-4eseA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		4 VAL A 204
VAL A 315
ASP A 313
VAL A 271
 None
 0.56A 4l4bA-4hxyA:
undetectable		 4l4bA-4hxyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7g TRYPSIN-LIKE
PROTEASE

(Saccharopolyspora
erythraea) 		PF00089
(Trypsin) 		4 THR A  44
LEU A  92
VAL A  37
VAL A 192
 None
 1.04A 4l4bA-4m7gA:
undetectable		 4l4bA-4m7gA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 THR A 377
LEU A 434
VAL A 405
VAL A 294
 None
 1.04A 4l4bA-4on9A:
undetectable		 4l4bA-4on9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 THR A4328
LEU A4333
VAL A4336
ASP A4476
 None
 1.07A 4l4bA-4opeA:
undetectable		 4l4bA-4opeA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovx XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

(Planctopirus
limnophila) 		PF01261
(AP_endonuc_2) 		4 THR A 265
VAL A 239
VAL A 283
VAL A 249
 None
 0.96A 4l4bA-4ovxA:
undetectable		 4l4bA-4ovxA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppr PENICILLIN-BINDING
PROTEIN DACB1

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		4 THR A 210
VAL A 125
VAL A 307
VAL A 294
 None
 0.99A 4l4bA-4pprA:
undetectable		 4l4bA-4pprA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1)
PF10394
(Hat1_N) 		4 TYR A  71
VAL A  83
VAL A  98
VAL A  67
 None
 0.77A 4l4bA-4pswA:
undetectable		 4l4bA-4pswA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		4 THR A 382
LEU A  98
VAL A 258
VAL A 352
 None
 0.64A 4l4bA-4qbuA:
undetectable		 4l4bA-4qbuA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txd CSC2

(Thermofilum
pendens) 		no annotation 4 THR A  85
LEU A 249
VAL A 264
VAL A  39
 None
 1.03A 4l4bA-4txdA:
undetectable		 4l4bA-4txdA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ui9 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 11
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2

(Homo sapiens;
Homo sapiens) 		PF12861
(zf-ANAPC11)
PF00888
(Cullin) 		4 LEU N 705
VAL N 704
VAL B   3
VAL N 648
 None
 1.06A 4l4bA-4ui9N:
undetectable		 4l4bA-4ui9N:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcg THERMOSOME SUBUNIT
BETA

(Sulfolobus
solfataricus) 		PF00118
(Cpn60_TCP1) 		4 THR B 337
VAL B 299
VAL B 230
VAL B 370
 None
 0.85A 4l4bA-4xcgB:
undetectable		 4l4bA-4xcgB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		4 PHE A 163
TYR A 202
VAL A 151
VAL A 117
 None
 0.92A 4l4bA-4y96A:
undetectable		 4l4bA-4y96A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		4 LEU A 125
VAL A 101
VAL A  82
VAL A  85
 None
 1.05A 4l4bA-4y9sA:
undetectable		 4l4bA-4y9sA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A

(Thermotoga
maritima;
Thermotoga
maritima) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF10418
(DHODB_Fe-S_bind)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 LEU B 263
VAL A  91
ASP A  89
VAL A  40
 None
 0.80A 4l4bA-4yryB:
undetectable		 4l4bA-4yryB:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		4 THR A  99
VAL A  84
ASP A  80
VAL A  85
 None
 0.95A 4l4bA-4yyfA:
undetectable		 4l4bA-4yyfA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		4 THR A  99
VAL A 123
VAL A  84
VAL A  85
 None
 0.88A 4l4bA-4yyfA:
undetectable		 4l4bA-4yyfA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8t AVRRXO1-ORF1

(Xanthomonas
oryzae) 		no annotation 4 THR A 184
LEU A 142
VAL A 243
VAL A 194
 None
 0.84A 4l4bA-4z8tA:
undetectable		 4l4bA-4z8tA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zc0 REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 PHE A  40
LEU A  53
ASP A  39
VAL A  98
 None
 0.60A 4l4bA-4zc0A:
undetectable		 4l4bA-4zc0A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpm PROTEIN PCDHAC2

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 LEU A 254
VAL A 293
VAL A 234
VAL A 235
 None
 0.82A 4l4bA-4zpmA:
undetectable		 4l4bA-4zpmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.05A 4l4bA-5a2rA:
undetectable		 4l4bA-5a2rA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		4 LEU A  26
VAL A  41
ASP A  43
VAL A 107
 None
None
SAH  A 301 ( 4.5A)
None
 1.00A 4l4bA-5bp7A:
undetectable		 4l4bA-5bp7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		4 PHE A 159
THR A 177
VAL A 144
VAL A 267
 None
None
5F7  A 401 ( 4.6A)
5F7  A 401 (-4.5A)
 0.93A 4l4bA-5dtrA:
undetectable		 4l4bA-5dtrA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 TYR A 255
THR A 174
VAL A  42
VAL A 251
 None
 0.97A 4l4bA-5eoeA:
undetectable		 4l4bA-5eoeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE

(Thiobacillus
denitrificans) 		PF13847
(Methyltransf_31) 		4 LEU A  25
VAL A  40
ASP A  42
VAL A 106
 None
None
SAH  A 301 ( 4.5A)
None
 1.01A 4l4bA-5epeA:
undetectable		 4l4bA-5epeA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 TYR A 418
LEU A 326
VAL A 322
VAL A 297
 None
 1.05A 4l4bA-5epgA:
undetectable		 4l4bA-5epgA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5v PRP38

(Chaetomium
thermophilum) 		PF03371
(PRP38) 		4 TYR A 105
LEU A 119
VAL A  65
VAL A  56
 None
 0.95A 4l4bA-5f5vA:
undetectable		 4l4bA-5f5vA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inw PUTATIVE
ANGIOTENSINOGEN
C-TERMINAL PEPTIDE
OF PUTATIVE
ANGIOTENSINOGEN

(Lampetra
fluviatilis;
Lampetra
fluviatilis) 		PF00079
(Serpin)
PF00079
(Serpin) 		4 PHE A 351
THR A 405
VAL C 432
VAL C 426
 None
 0.73A 4l4bA-5inwA:
undetectable		 4l4bA-5inwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isu LMO0135 PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		4 THR A 169
VAL A 122
VAL A  99
VAL A 155
 None
 0.88A 4l4bA-5isuA:
undetectable		 4l4bA-5isuA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Archaeoglobus
fulgidus) 		no annotation 4 THR A 134
LEU A 232
VAL A 241
VAL A 191
 None
 0.95A 4l4bA-5mqzA:
undetectable		 4l4bA-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 4 TYR A 322
THR A 343
VAL A 547
VAL A 543
 None
 1.01A 4l4bA-5mz9A:
undetectable		 4l4bA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B
HETERODISULFIDE
REDUCTASE, SUBUNIT C

(Methanothermococcus
thermolithotrophicus;
Methanothermococcus
thermolithotrophicus) 		PF02754
(CCG)
PF13183
(Fer4_8) 		4 THR C  50
LEU B 207
VAL B 200
ASP C  73
 None
 1.01A 4l4bA-5odrC:
undetectable		 4l4bA-5odrC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 THR A 127
LEU A 195
VAL A 198
VAL A  32
 None
 1.01A 4l4bA-5w4xA:
undetectable		 4l4bA-5w4xA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwp ORF1AB

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 LEU B 438
VAL B 372
ASP B 374
VAL B 397
 None
 0.96A 4l4bA-5wwpB:
undetectable		 4l4bA-5wwpB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2g CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Campylobacter
jejuni) 		no annotation 4 PHE A   7
TYR A 459
THR A 651
LEU A 435
 None
 1.06A 4l4bA-5x2gA:
undetectable		 4l4bA-5x2gA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C

(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation
no annotation 		4 LEU E  79
VAL G  84
VAL D  76
VAL D  72
 None
 0.94A 4l4bA-6cfwE:
undetectable		 4l4bA-6cfwE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC5
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC4

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 THR N 389
VAL N 412
VAL M 176
VAL M  87
 None
 0.93A 4l4bA-6eu2N:
undetectable		 4l4bA-6eu2N:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 4 THR A 805
LEU A 761
VAL A 760
VAL A 676
 None
 1.04A 4l4bA-6gh2A:
undetectable		 4l4bA-6gh2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6glc E3 UBIQUITIN-PROTEIN
LIGASE PARKIN

(Homo sapiens) 		no annotation 4 THR A  21
VAL A  29
VAL A  67
VAL A   5
 None
 0.88A 4l4bA-6glcA:
undetectable		 4l4bA-6glcA:
undetectable