SIMILAR PATTERNS OF AMINO ACIDS FOR 4L3G_F_ACTF401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		3 ARG A 119
LEU A 116
GLU A 120
 None
 0.66A 4l3gF-1cbfA:
0.0		 4l3gF-1cbfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehi D-ALANINE:D-LACTATE
LIGASE

(Leuconostoc
mesenteroides) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 ARG A 223
LEU A 306
GLU A 224
 None
None
ADP  A 781 (-2.7A)
 0.74A 4l3gF-1ehiA:
0.1		 4l3gF-1ehiA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)

(Agrobacterium
tumefaciens) 		PF00561
(Abhydrolase_1) 		3 ARG A 186
LEU A 189
GLU A 188
 None
 0.74A 4l3gF-1ehyA:
0.0		 4l3gF-1ehyA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuu YEAST INITIATION
FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		3 ARG A  34
LEU A  33
GLU A  30
 None
 0.66A 4l3gF-1fuuA:
undetectable		 4l3gF-1fuuA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6o CAG-ALPHA

(Helicobacter
pylori) 		PF00437
(T2SSE) 		3 ARG A  29
LEU A  25
GLU A  22
 None
 0.75A 4l3gF-1g6oA:
0.0		 4l3gF-1g6oA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8p MAGNESIUM-CHELATASE
38 KDA SUBUNIT

(Rhodobacter
capsulatus) 		PF01078
(Mg_chelatase) 		3 ARG A 260
LEU A 257
GLU A 261
 None
 0.76A 4l3gF-1g8pA:
0.0		 4l3gF-1g8pA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ARG A 283
LEU A 287
GLU A 286
 None
 0.70A 4l3gF-1lv2A:
0.0		 4l3gF-1lv2A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0w GLUTATHIONE
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		3 ARG A 285
LEU A 237
GLU A 238
 3GC  A 501 (-3.8A)
None
None
 0.71A 4l3gF-1m0wA:
0.0		 4l3gF-1m0wA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		3 ARG A 271
LEU A  52
GLU A  53
 None
 0.68A 4l3gF-1mhsA:
0.0		 4l3gF-1mhsA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		3 ARG B 313
LEU B 310
GLU B 265
 None
 0.76A 4l3gF-1n94B:
undetectable		 4l3gF-1n94B:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf6 BACTERIOFERRITIN

(Desulfovibrio
desulfuricans) 		PF00210
(Ferritin) 		3 ARG A  20
LEU A  24
GLU A  23
 FEC  A1005 (-2.7A)
None
None
 0.72A 4l3gF-1nf6A:
undetectable		 4l3gF-1nf6A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ARG A 207
LEU A 349
GLU A 346
 None
 0.66A 4l3gF-1np7A:
undetectable		 4l3gF-1np7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		3 ARG A 197
LEU A 201
GLU A 200
 None
 0.73A 4l3gF-1piiA:
undetectable		 4l3gF-1piiA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxd GA REPEAT BINDING
PROTEIN, ALPHA

(Mus musculus) 		PF02198
(SAM_PNT) 		3 ARG A 248
LEU A 244
GLU A 245
 None
 0.67A 4l3gF-1sxdA:
undetectable		 4l3gF-1sxdA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1va8 MAGUK P55 SUBFAMILY
MEMBER 5

(Mus musculus) 		PF00595
(PDZ) 		3 ARG A  82
LEU A  74
GLU A  80
 None
 0.59A 4l3gF-1va8A:
undetectable		 4l3gF-1va8A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Thermotoga
maritima) 		PF01039
(Carboxyl_trans) 		3 ARG A 151
LEU A 150
GLU A 147
 None
 0.48A 4l3gF-1vrgA:
undetectable		 4l3gF-1vrgA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdj HYPOTHETICAL PROTEIN
TT1808

(Thermus
thermophilus) 		PF05685
(Uma2) 		3 ARG A  18
LEU A  22
GLU A  21
 None
 0.77A 4l3gF-1wdjA:
undetectable		 4l3gF-1wdjA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wol 122AA LONG CONSERVED
HYPOTHETICAL PROTEIN

(Sulfurisphaera
tokodaii) 		PF05168
(HEPN) 		3 ARG A  19
LEU A  15
GLU A  16
 None
 0.70A 4l3gF-1wolA:
undetectable		 4l3gF-1wolA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA

(Bacillus
subtilis) 		PF00496
(SBP_bac_5) 		3 ARG A 119
LEU A 440
GLU A 118
 None
None
ZN  A 530 (-2.3A)
 0.75A 4l3gF-1xocA:
undetectable		 4l3gF-1xocA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y74 LIN 7 HOMOLOG B

(Mus musculus) 		PF02828
(L27) 		3 ARG A  25
LEU A  29
GLU A  28
 None
 0.71A 4l3gF-1y74A:
undetectable		 4l3gF-1y74A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zi7 KES1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01237
(Oxysterol_BP) 		3 ARG A 360
LEU A 311
GLU A 312
 None
 0.73A 4l3gF-1zi7A:
0.5		 4l3gF-1zi7A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa1 PROBABLE
TRANSCRIPTIONAL
REGULATOR PHNF

(Escherichia
coli) 		PF07702
(UTRA) 		3 ARG A 137
LEU A 135
GLU A 104
 None
 0.72A 4l3gF-2fa1A:
2.1		 4l3gF-2fa1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Sulfurisphaera
tokodaii) 		PF04321
(RmlD_sub_bind) 		3 ARG A  18
LEU A  19
GLU A  22
 None
 0.70A 4l3gF-2ggsA:
undetectable		 4l3gF-2ggsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		3 ARG A 345
LEU A 359
GLU A 358
 None
 0.76A 4l3gF-2gjmA:
undetectable		 4l3gF-2gjmA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Thermus
thermophilus) 		PF05690
(ThiG) 		3 ARG A 173
LEU A 170
GLU A 174
 None
 0.65A 4l3gF-2htmA:
undetectable		 4l3gF-2htmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwx TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF13638
(PIN_4) 		3 ARG A1269
LEU A1266
GLU A1267
 None
 0.73A 4l3gF-2hwxA:
undetectable		 4l3gF-2hwxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 946
LEU A 942
GLU A 943
 None
 0.76A 4l3gF-2i1yA:
undetectable		 4l3gF-2i1yA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ARG A  68
LEU A  45
GLU A  71
 None
 0.67A 4l3gF-2i3aA:
0.5		 4l3gF-2i3aA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lm5 CALCIUM AND
INTEGRIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 ARG A 143
LEU A 152
GLU A 148
 None
 0.68A 4l3gF-2lm5A:
undetectable		 4l3gF-2lm5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oap TYPE II SECRETION
SYSTEM PROTEIN

(Archaeoglobus
fulgidus) 		PF00437
(T2SSE) 		3 ARG 1 473
LEU 1 477
GLU 1 476
 None
 0.74A 4l3gF-2oap1:
undetectable		 4l3gF-2oap1:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		3 ARG A  27
LEU A  23
GLU A  24
 None
 0.65A 4l3gF-2ozeA:
undetectable		 4l3gF-2ozeA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5z TYPE VI SECRETION
SYSTEM COMPONENT

(Escherichia
coli) 		PF05954
(Phage_GPD) 		3 ARG X 368
LEU X 305
GLU X 302
 None
 0.64A 4l3gF-2p5zX:
undetectable		 4l3gF-2p5zX:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6d DIPHTHINE SYNTHASE

(Pyrococcus
horikoshii) 		PF00590
(TP_methylase) 		3 ARG A 258
LEU A 261
GLU A 259
 None
 0.72A 4l3gF-2p6dA:
undetectable		 4l3gF-2p6dA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 982
LEU A 978
GLU A 979
 None
 0.74A 4l3gF-2qepA:
undetectable		 4l3gF-2qepA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpt COLICIN-E2 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF01320
(Colicin_Pyocin) 		3 ARG A  42
LEU A  43
GLU A  45
 NO3  A1087 (-3.6A)
None
None
 0.63A 4l3gF-2wptA:
undetectable		 4l3gF-2wptA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xko GLOBAL NITROGEN
REGULATOR

(Synechococcus
elongatus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		3 ARG A 114
LEU A 117
GLU A 116
 None
 0.69A 4l3gF-2xkoA:
undetectable		 4l3gF-2xkoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 ARG A1150
LEU A1094
GLU A1095
 None
 0.68A 4l3gF-2xt6A:
undetectable		 4l3gF-2xt6A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT FACTOR B

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA) 		3 ARG F 521
LEU F 523
GLU F 524
 None
 0.60A 4l3gF-2xwbF:
undetectable		 4l3gF-2xwbF:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		3 ARG A  70
LEU A  65
GLU A  69
 None
 0.71A 4l3gF-2yz2A:
undetectable		 4l3gF-2yz2A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		3 ARG A 143
LEU A 114
GLU A 165
 None
None
PO4  A 261 (-3.2A)
 0.59A 4l3gF-3a9lA:
undetectable		 4l3gF-3a9lA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Mus musculus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 ARG A 700
LEU A 697
GLU A 701
 None
 0.62A 4l3gF-3cf0A:
undetectable		 4l3gF-3cf0A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do9 UPF0302 PROTEIN
BA_1542/GBAA1542/BAS
1430

(Bacillus
anthracis) 		PF08858
(IDEAL)
PF08864
(UPF0302) 		3 ARG A 170
LEU A 171
GLU A 174
 None
 0.75A 4l3gF-3do9A:
undetectable		 4l3gF-3do9A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwc METALLOCARBOXYPEPTID
ASE

(Trypanosoma
cruzi) 		PF02074
(Peptidase_M32) 		3 ARG A  87
LEU A  91
GLU A  90
 None
 0.76A 4l3gF-3dwcA:
undetectable		 4l3gF-3dwcA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ARG A 324
LEU A 328
GLU A 327
 None
 0.76A 4l3gF-3fs1A:
undetectable		 4l3gF-3fs1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		3 ARG A 175
LEU A 172
GLU A 176
 None
 0.75A 4l3gF-3h9pA:
undetectable		 4l3gF-3h9pA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihm STYRENE
MONOOXYGENASE A

(Pseudomonas
putida) 		no annotation 3 ARG A 340
LEU A 318
GLU A 321
 None
 0.72A 4l3gF-3ihmA:
undetectable		 4l3gF-3ihmA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbk METAVINCULIN

(Homo sapiens) 		PF01044
(Vinculin) 		3 ARG M 963
LEU M 964
GLU M 967
 None
 0.68A 4l3gF-3jbkM:
undetectable		 4l3gF-3jbkM:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsr ALL0216 PROTEIN

(Nostoc sp. PCC
7120) 		PF10674
(Ycf54) 		3 ARG A  84
LEU A  85
GLU A  86
 None
 0.54A 4l3gF-3jsrA:
undetectable		 4l3gF-3jsrA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdq UNCHARACTERIZED
CONSERVED PROTEIN

(Corynebacterium
diphtheriae) 		no annotation 3 ARG A  16
LEU A  20
GLU A  19
 None
 0.75A 4l3gF-3kdqA:
undetectable		 4l3gF-3kdqA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyg 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacterium
tuberculosis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ARG A 155
LEU A  31
GLU A  30
 None
 0.71A 4l3gF-3pygA:
undetectable		 4l3gF-3pygA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 ARG A 189
LEU A 191
GLU A 190
 None
 0.64A 4l3gF-3rb9A:
undetectable		 4l3gF-3rb9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u67 HEAT SHOCK PROTEIN
83-1

(Leishmania
major) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 ARG A 187
LEU A 191
GLU A 190
 None
 0.71A 4l3gF-3u67A:
undetectable		 4l3gF-3u67A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04410
(Gar1) 		3 ARG C  54
LEU C  44
GLU C 105
 None
 0.77A 4l3gF-3uaiC:
undetectable		 4l3gF-3uaiC:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfi THIOREDOXIN

(Silicibacter
phage DSS3phi2) 		PF00085
(Thioredoxin) 		3 ARG A  85
LEU A  78
GLU A  86
 None
 0.76A 4l3gF-3vfiA:
undetectable		 4l3gF-3vfiA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0t UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		no annotation 3 ARG A  39
LEU A 112
GLU A 113
 None
 0.69A 4l3gF-3x0tA:
undetectable		 4l3gF-3x0tA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 ARG A1091
LEU A1094
GLU A1095
 None
 0.72A 4l3gF-3zhrA:
undetectable		 4l3gF-3zhrA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		3 ARG A 216
LEU A 210
GLU A 211
 None
 0.74A 4l3gF-4b6lA:
2.9		 4l3gF-4b6lA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bil DNA MATURASE B

(Escherichia
virus T7) 		no annotation 3 ARG A 216
LEU A 212
GLU A 213
 None
 0.67A 4l3gF-4bilA:
0.8		 4l3gF-4bilA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bok ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03663
(Glyco_hydro_76) 		3 ARG A 150
LEU A 146
GLU A 147
 None
 0.75A 4l3gF-4bokA:
undetectable		 4l3gF-4bokA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7n SYNTHETIC
ALPHA-HELIX, IM10

(synthetic
construct) 		no annotation 3 ARG B  17
LEU B  21
GLU B  20
 None
None
HG  B1056 (-3.9A)
 0.75A 4l3gF-4c7nB:
undetectable		 4l3gF-4c7nB:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica) 		PF00069
(Pkinase)
PF09632
(Rac1) 		3 ARG B 720
LEU B 724
GLU B 727
 None
 0.62A 4l3gF-4ci6B:
undetectable		 4l3gF-4ci6B:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ekd GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(Q) SUBUNIT
ALPHA

(Mus musculus) 		PF00503
(G-alpha) 		3 ARG A  38
LEU A  40
GLU A  39
 None
 0.67A 4l3gF-4ekdA:
undetectable		 4l3gF-4ekdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4goq HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF07372
(DUF1491) 		3 ARG A  14
LEU A  18
GLU A  17
 None
 0.65A 4l3gF-4goqA:
undetectable		 4l3gF-4goqA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu4 ARGINASE

(Leishmania
mexicana) 		PF00491
(Arginase) 		3 ARG A  58
LEU A  19
GLU A  57
 None
 0.76A 4l3gF-4iu4A:
undetectable		 4l3gF-4iu4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Sanguibacter
keddieii) 		PF13377
(Peripla_BP_3) 		3 ARG A 110
LEU A 114
GLU A 113
 None
 0.63A 4l3gF-4kmrA:
undetectable		 4l3gF-4kmrA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbo STEROID RECEPTOR RNA
ACTIVATOR 1

(Homo sapiens) 		PF07304
(SRA1) 		3 ARG A 126
LEU A 122
GLU A 123
 None
 0.54A 4l3gF-4nboA:
undetectable		 4l3gF-4nboA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq1 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Legionella
pneumophila) 		PF00701
(DHDPS) 		3 ARG A 174
LEU A 175
GLU A 177
 None
 0.67A 4l3gF-4nq1A:
undetectable		 4l3gF-4nq1A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7p MALTOKINASE

(Mycobacterium
tuberculosis) 		no annotation 3 ARG A 186
LEU A 188
GLU A 125
 None
 0.73A 4l3gF-4o7pA:
2.1		 4l3gF-4o7pA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7e RESPONSE REGULATOR
OF A TWO COMPONENT
REGULATORY SYSTEM

(Leptospira
biflexa) 		PF00072
(Response_reg) 		3 ARG A  91
LEU A  95
GLU A  94
 None
 0.74A 4l3gF-4q7eA:
undetectable		 4l3gF-4q7eA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Homo sapiens) 		PF12157
(DUF3591) 		3 ARG A 795
LEU A 797
GLU A 796
 GOL  A1301 ( 4.6A)
GOL  A1301 (-4.4A)
None
 0.75A 4l3gF-4rgwA:
undetectable		 4l3gF-4rgwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3n CALCIUM-REGULATED
ACTIN-BUNDLING
PROTEIN

(Dictyostelium
discoideum) 		no annotation 3 ARG A 187
LEU A 188
GLU A 191
 None
 0.61A 4l3gF-4x3nA:
undetectable		 4l3gF-4x3nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9i MYCOBACTERIUM
TUBERCULOSIS
PARALOGOUS FAMILY 11

(Mycolicibacterium
smegmatis) 		PF04075
(F420H2_quin_red) 		3 ARG A 102
LEU A 104
GLU A 105
 None
 0.54A 4l3gF-4y9iA:
undetectable		 4l3gF-4y9iA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zck GTP-BINDING PROTEIN
TYPA/BIPA

(Escherichia
coli) 		PF00679
(EFG_C) 		3 ARG A 590
LEU A 577
GLU A 576
 None
 0.76A 4l3gF-4zckA:
undetectable		 4l3gF-4zckA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpi PUTATIVE
OXIDASE/HYDROXYLASE

(Streptomyces
hygroscopicus) 		PF05721
(PhyH) 		3 ARG A 233
LEU A 235
GLU A 234
 None
 0.69A 4l3gF-4zpiA:
undetectable		 4l3gF-4zpiA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aho 5' EXONUCLEASE
APOLLO

(Homo sapiens) 		PF07522
(DRMBL) 		3 ARG A 206
LEU A 210
GLU A 209
 None
 0.70A 4l3gF-5ahoA:
undetectable		 4l3gF-5ahoA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		3 ARG A  27
LEU A  28
GLU A  29
 None
 0.75A 4l3gF-5aypA:
undetectable		 4l3gF-5aypA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		3 ARG A 591
LEU A 595
GLU A 594
 None
 0.65A 4l3gF-5eawA:
2.1		 4l3gF-5eawA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Homo sapiens) 		PF12157
(DUF3591) 		3 ARG G 795
LEU G 797
GLU G 796
 None
 0.74A 4l3gF-5furG:
undetectable		 4l3gF-5furG:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		3 ARG A 422
LEU A 423
GLU A 400
 SO4  A 917 (-3.9A)
None
None
 0.74A 4l3gF-5gmhA:
undetectable		 4l3gF-5gmhA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipw OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		3 ARG A 353
LEU A 355
GLU A 636
 None
 0.65A 4l3gF-5ipwA:
undetectable		 4l3gF-5ipwA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1g PLECTIN

(Homo sapiens) 		no annotation 3 ARG A1069
LEU A1070
GLU A1073
 None
 0.69A 4l3gF-5j1gA:
undetectable		 4l3gF-5j1gA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		3 ARG L  37
LEU L  34
GLU L  38
 None
 0.71A 4l3gF-5jfcL:
undetectable		 4l3gF-5jfcL:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		3 ARG A2027
LEU A2023
GLU A2024
 None
 0.58A 4l3gF-5lkiA:
6.5		 4l3gF-5lkiA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1

(Rhodococcus
jostii) 		PF00296
(Bac_luciferase) 		3 ARG A 318
LEU A 322
GLU A 321
 GOL  A 401 ( 4.7A)
GOL  A 401 ( 4.9A)
GOL  A 401 (-3.7A)
 0.74A 4l3gF-5lxeA:
undetectable		 4l3gF-5lxeA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ARG A  87
LEU A  89
GLU A  88
 None
 0.74A 4l3gF-5macA:
undetectable		 4l3gF-5macA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mv0 L PROTEIN

(California
reptarenavirus) 		PF17296
(ArenaCapSnatch) 		3 ARG A 154
LEU A 155
GLU A 158
 None
 0.60A 4l3gF-5mv0A:
undetectable		 4l3gF-5mv0A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME C1, HEME
PROTEIN,
MITOCHONDRIAL

(Bos taurus) 		PF02167
(Cytochrom_C1) 		3 ARG D 144
LEU D 147
GLU D 145
 None
 0.64A 4l3gF-5nmiD:
undetectable		 4l3gF-5nmiD:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nws SAACMM

(Streptomyces
antibioticus) 		no annotation 3 ARG A 152
LEU A 153
GLU A 156
 None
 0.74A 4l3gF-5nwsA:
undetectable		 4l3gF-5nwsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5x CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ARG A 478
LEU A 479
GLU A 482
 None
 0.73A 4l3gF-5t5xA:
undetectable		 4l3gF-5t5xA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		3 ARG A 221
LEU A 223
GLU A 225
 None
 0.70A 4l3gF-5vwmA:
undetectable		 4l3gF-5vwmA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Homo sapiens) 		no annotation 3 ARG A1064
LEU A1065
GLU A1068
 None
 0.70A 4l3gF-5wp6A:
undetectable		 4l3gF-5wp6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xei CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
yayanosii) 		PF02463
(SMC_N) 		3 ARG A 980
LEU A 984
GLU A 983
 None
 0.75A 4l3gF-5xeiA:
1.7		 4l3gF-5xeiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xev XAA-PRO
DIPEPTIDASE,PEPTIDAS
E-RELATED PROTEIN

(Deinococcus
radiodurans) 		no annotation 3 ARG A 128
LEU A 124
GLU A 125
 None
 0.75A 4l3gF-5xevA:
0.9		 4l3gF-5xevA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		3 ARG A 980
LEU A 984
GLU A 983
 None
 0.72A 4l3gF-5xnsA:
undetectable		 4l3gF-5xnsA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y05 MSMEG_4306

(Mycolicibacterium
smegmatis) 		no annotation 3 ARG A 131
LEU A 135
GLU A 134
 None
 0.74A 4l3gF-5y05A:
undetectable		 4l3gF-5y05A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbl NEAMINE TRANSAMINASE
NEON

(Streptomyces
fradiae) 		no annotation 3 ARG A 116
LEU A 113
GLU A 117
 None
 0.72A 4l3gF-6cblA:
undetectable		 4l3gF-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek2 SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 3 ARG H 383
LEU H 385
GLU H 393
 None
 0.74A 4l3gF-6ek2H:
undetectable		 4l3gF-6ek2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exn PRE-MRNA-SPLICING
FACTOR CLF1

(Saccharomyces
cerevisiae) 		no annotation 3 ARG S  44
LEU S  40
GLU S  41
 None
 0.67A 4l3gF-6exnS:
undetectable		 4l3gF-6exnS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 3 ARG B 260
LEU B 264
GLU B 263
 None
 0.62A 4l3gF-6fd2B:
undetectable		 4l3gF-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE

(Coptis japonica) 		no annotation 3 ARG A  36
LEU A  33
GLU A  37
 None
 0.76A 4l3gF-6gkvA:
undetectable		 4l3gF-6gkvA:
undetectable