SIMILAR PATTERNS OF AMINO ACIDS FOR 4L39_B_SALB601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2e ELONGATION FACTOR TU
(EF-TU)


(Bos taurus)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
4 THR A 139
ILE A 106
THR A 430
GLY A 432
None
0.89A 4l39B-1d2eA:
undetectable
4l39B-1d2eA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnn CELL DIVISION
CONTROL PROTEIN 6


(Pyrobaculum
aerophilum)
PF09079
(Cdc6_C)
PF13401
(AAA_22)
4 LEU A 274
THR A 226
ILE A 222
GLY A 368
None
0.89A 4l39B-1fnnA:
0.4
4l39B-1fnnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsd HAEMAGGLUTININ (HA1
CHAIN)


(Influenza A
virus)
PF00509
(Hemagglutinin)
4 LEU A 184
TYR A 185
ILE A 242
GLY A 128
None
0.90A 4l39B-1jsdA:
undetectable
4l39B-1jsdA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini)
PF02274
(Amidinotransf)
5 LEU A 374
TYR A 353
THR A 370
ILE A 332
THR A 275
None
1.48A 4l39B-1lxyA:
undetectable
4l39B-1lxyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi1 SCML2 PROTEIN

(Homo sapiens)
PF02820
(MBT)
4 LEU A 109
ILE A 189
THR A 233
GLY A  90
None
0.89A 4l39B-1oi1A:
undetectable
4l39B-1oi1A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osg TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B


(Homo sapiens)
PF00229
(TNF)
4 LEU A 261
THR A 277
ILE A 270
GLY A 209
None
0.86A 4l39B-1osgA:
undetectable
4l39B-1osgA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw5 NAGD PROTEIN,
PUTATIVE


(Thermotoga
maritima)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
4 LEU A  92
THR A  95
THR A 146
GLY A  74
None
0.88A 4l39B-1pw5A:
1.5
4l39B-1pw5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F

(Chlamydomonas
reinhardtii)
PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N)
4 LEU A 100
TYR A 102
ILE A  49
GLY A  72
None
None
None
HEM  A 900 (-3.9A)
0.89A 4l39B-1q90A:
undetectable
4l39B-1q90A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rty YVQK PROTEIN

(Bacillus
subtilis)
PF01923
(Cob_adeno_trans)
4 LEU A  93
TYR A 152
ILE A  40
THR A 129
None
0.93A 4l39B-1rtyA:
undetectable
4l39B-1rtyA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ti8 HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.95A 4l39B-1ti8A:
undetectable
4l39B-1ti8A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v29 NITRILE HYDRATASE B
CHAIN


(Bacillus
smithii)
PF02211
(NHase_beta)
4 LEU B 206
ILE B 217
THR B 150
GLY B 170
None
0.96A 4l39B-1v29B:
undetectable
4l39B-1v29B:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xaj 3-DEHYDROQUINATE
SYNTHASE


(Staphylococcus
aureus)
PF01761
(DHQ_synthase)
4 LEU A 184
TYR A 180
ILE A 265
GLY A 241
None
0.88A 4l39B-1xajA:
undetectable
4l39B-1xajA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsa BIS(5'-NUCLEOSYL)-TE
TRAPHOSPHATASE


(Homo sapiens)
PF00293
(NUDIX)
4 THR A  95
ILE A  97
THR A  59
GLY A  48
None
0.96A 4l39B-1xsaA:
undetectable
4l39B-1xsaA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3d MODULATOR OF DRUG
ACTIVITY B


(Escherichia
coli)
PF02525
(Flavodoxin_2)
4 LEU A 199
TYR A 195
ILE A  17
GLY A  41
None
0.82A 4l39B-2b3dA:
1.8
4l39B-2b3dA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC


(Lactococcus
lactis)
PF05147
(LANC_like)
4 LEU A  39
TYR A  88
ILE A 329
GLY A 377
None
0.73A 4l39B-2g02A:
undetectable
4l39B-2g02A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdn ELONGATION FACTOR
EF-TU


(Escherichia
coli)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
4 LEU B 311
THR B 382
THR B  93
GLY B 386
None
0.96A 4l39B-2hdnB:
1.4
4l39B-2hdnB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB


(Methanocaldococcus
jannaschii)
PF02492
(cobW)
4 LEU A  28
THR A 135
ILE A 119
GLY A 103
None
0.72A 4l39B-2hf8A:
1.9
4l39B-2hf8A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iun AVIAN ADENOVIRUS
CELO LONG FIBRE


(Fowl
aviadenovirus A)
PF16812
(AdHead_fibreRBD)
4 LEU A 759
THR A 781
ILE A 784
GLY A 756
None
0.92A 4l39B-2iunA:
undetectable
4l39B-2iunA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE


(Homo sapiens)
PF01053
(Cys_Met_Meta_PP)
4 THR A 163
ILE A 369
THR A 355
GLY A 115
None
0.96A 4l39B-2nmpA:
undetectable
4l39B-2nmpA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0k POLYCOMB PROTEIN
SCMH1


(Homo sapiens)
PF02820
(MBT)
4 LEU A 104
ILE A 184
THR A 228
GLY A  85
None
0.80A 4l39B-2p0kA:
undetectable
4l39B-2p0kA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4y URIDYLATE KINASE

(Escherichia
coli)
PF00696
(AA_kinase)
4 LEU A 197
THR A 172
THR A 237
GLY A 169
None
0.84A 4l39B-2v4yA:
undetectable
4l39B-2v4yA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrd HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 LEU A 193
TYR A 194
ILE A 251
GLY A 133
None
0.87A 4l39B-2wrdA:
undetectable
4l39B-2wrdA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y89 PHOSPHORIBOSYL
ISOMERASE A


(Mycobacterium
tuberculosis)
PF00977
(His_biosynth)
4 LEU A 185
THR A 170
ILE A 172
GLY A 176
None
0.91A 4l39B-2y89A:
undetectable
4l39B-2y89A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.82A 4l39B-2yp2A:
undetectable
4l39B-2yp2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE


(Bifidobacterium
longum)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
4 TYR A 447
THR A 438
ILE A 432
GLY A 416
None
0.93A 4l39B-3ai7A:
undetectable
4l39B-3ai7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981)
4 TYR A 898
ARG A 901
THR A 927
GLY A 554
None
0.86A 4l39B-3bgaA:
undetectable
4l39B-3bgaA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE, ADP-BINDING
SUBUNIT DHAL
PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
PHOSPHOTRANSFERASE
SUBUNIT DHAM


(Lactococcus
lactis)
PF02734
(Dak2)
PF03610
(EIIA-man)
4 LEU C  67
ILE C  42
THR C  44
GLY A  77
None
None
None
ADP  A1211 (-3.3A)
0.88A 4l39B-3cr3C:
undetectable
4l39B-3cr3C:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE


(Salmonella
enterica)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 THR A 123
ILE A 137
THR A 284
GLY A 130
None
0.91A 4l39B-3d46A:
undetectable
4l39B-3d46A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE


(Corynebacterium
diphtheriae)
PF12897
(Aminotran_MocR)
4 LEU A  50
ILE A  78
THR A 253
GLY A 262
None
0.91A 4l39B-3d6kA:
undetectable
4l39B-3d6kA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981)
4 TYR A 874
ARG A 877
THR A 903
GLY A 530
None
0.89A 4l39B-3decA:
3.0
4l39B-3decA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eof PUTATIVE
OXIDOREDUCTASE


(Bacteroides
fragilis)
PF00881
(Nitroreductase)
4 THR A  75
ILE A 140
THR A 134
GLY A 131
None
None
None
FMN  A 300 (-3.5A)
0.74A 4l39B-3eofA:
undetectable
4l39B-3eofA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN


(Influenza A
virus)
PF00509
(Hemagglutinin)
4 LEU A 196
TYR A 197
ILE A 254
GLY A 134
None
0.95A 4l39B-3eykA:
undetectable
4l39B-3eykA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f72 CADMIUM EFFLUX
SYSTEM ACCESSORY
PROTEIN


(Staphylococcus
aureus)
PF01022
(HTH_5)
4 LEU A  99
THR A  48
ILE A  39
GLY A  84
None
0.83A 4l39B-3f72A:
undetectable
4l39B-3f72A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus)
PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C)
4 LEU A  70
TYR A 144
ILE A 159
GLY A  64
None
0.81A 4l39B-3gdeA:
undetectable
4l39B-3gdeA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2


(Bluetongue
virus)
PF00898
(Orbi_VP2)
4 LEU A 604
TYR A 600
THR A 621
GLY A 161
None
0.92A 4l39B-3j9dA:
3.1
4l39B-3j9dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2


(Dichelobacter
nodosus)
PF00082
(Peptidase_S8)
4 LEU A 321
THR A 229
ILE A 329
GLY A 326
None
0.89A 4l39B-3lpdA:
undetectable
4l39B-3lpdA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwf PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Listeria
innocua)
PF02082
(Rrf2)
4 LEU A  67
THR A  14
ILE A  79
GLY A  53
None
0.93A 4l39B-3lwfA:
undetectable
4l39B-3lwfA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n79 PDUT

(Salmonella
enterica)
PF00936
(BMC)
4 LEU A  10
THR A  61
ILE A  57
GLY A  20
None
0.95A 4l39B-3n79A:
undetectable
4l39B-3n79A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o59 DNA POLYMERASE II
LARGE SUBUNIT


(Pyrococcus
horikoshii)
PF03833
(PolC_DP2)
4 LEU X 250
TYR X 194
THR X 226
GLY X 148
None
0.90A 4l39B-3o59X:
2.2
4l39B-3o59X:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqi HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
None
None
EPE  A3380 (-3.4A)
0.81A 4l39B-3qqiA:
undetectable
4l39B-3qqiA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN


(Vibrio cholerae)
PF01497
(Peripla_BP_2)
4 LEU A  65
ILE A 142
THR A 162
GLY A 159
None
0.91A 4l39B-3r5tA:
undetectable
4l39B-3r5tA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M


(Escherichia
coli)
no annotation 4 LEU M 211
TYR M 207
ILE M 496
GLY M  59
None
0.85A 4l39B-3rkoM:
undetectable
4l39B-3rkoM:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV


(Dichelobacter
nodosus)
PF00082
(Peptidase_S8)
4 LEU A 321
THR A 229
ILE A 329
GLY A 326
None
0.89A 4l39B-3ti7A:
undetectable
4l39B-3ti7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u04 PEPTIDE DEFORMYLASE
1


(Ehrlichia
chaffeensis)
PF01327
(Pep_deformylase)
4 LEU A  14
THR A   8
ILE A   6
GLY A  53
None
0.87A 4l39B-3u04A:
undetectable
4l39B-3u04A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN


(Carboxydothermus
hydrogenoformans)
PF00111
(Fer2)
PF14574
(DUF4445)
4 LEU X 116
THR X 364
ILE X 539
GLY X 571
None
0.90A 4l39B-3zyyX:
undetectable
4l39B-3zyyX:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE


(Thermotoga
maritima)
PF02491
(SHS2_FTSA)
PF14450
(FtsA)
4 LEU A  64
ILE A  81
THR A  11
GLY A  22
None
0.79A 4l39B-4a2bA:
undetectable
4l39B-4a2bA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE


(Salmonella
enterica)
PF01909
(NTP_transf_2)
PF13427
(DUF4111)
4 LEU A  50
THR A  13
ILE A   5
GLY A  35
None
0.93A 4l39B-4cs6A:
undetectable
4l39B-4cs6A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans)
PF02274
(Amidinotransf)
5 LEU A 416
TYR A 395
THR A 412
ILE A 374
THR A 319
None
1.42A 4l39B-4e4jA:
undetectable
4l39B-4e4jA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g5e 2,4,6-TRICHLOROPHENO
L 4-MONOOXYGENASE


(Cupriavidus
pinatubonensis)
PF03241
(HpaB)
PF11794
(HpaB_N)
4 LEU A 253
THR A  34
ILE A  25
GLY A  21
None
0.93A 4l39B-4g5eA:
undetectable
4l39B-4g5eA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfu HEMAGGLUTININ HA1

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.94A 4l39B-4hfuA:
undetectable
4l39B-4hfuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkx HEMAGGLUTININ HA1

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 LEU E 194
TYR E 195
ILE E 252
GLY E 134
None
0.84A 4l39B-4hkxE:
undetectable
4l39B-4hkxE:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0q ELONGATION FACTOR
TU-A


(Pseudomonas
putida)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
4 LEU A 315
THR A 386
THR A  94
GLY A 390
None
0.96A 4l39B-4j0qA:
1.5
4l39B-4j0qA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula)
PF00407
(Bet_v_1)
4 LEU A  90
TYR A 133
ILE A  98
GLY A  87
None
EMU  A 202 ( 4.3A)
EMU  A 202 ( 4.9A)
None
0.82A 4l39B-4jhiA:
undetectable
4l39B-4jhiA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE


(Homo sapiens)
no annotation 4 THR B 150
ILE B 122
THR B 260
GLY B 258
None
None
PLP  B 601 (-3.3A)
PLP  B 601 (-3.5A)
0.95A 4l39B-4l27B:
undetectable
4l39B-4l27B:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmb CYSTEINE SYNTHASE

(Microcystis
aeruginosa)
PF00291
(PALP)
4 THR A  78
ILE A  49
THR A 185
GLY A 183
CYS  A 401 (-3.9A)
None
PLP  A 403 (-3.5A)
PLP  A 403 (-3.4A)
0.88A 4l39B-4lmbA:
2.2
4l39B-4lmbA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE


(Methylacidiphilum
fumariolicum)
PF13360
(PQQ_2)
4 ARG A 265
THR A 370
THR A 259
GLY A 427
None
0.65A 4l39B-4maeA:
undetectable
4l39B-4maeA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb7 ENDONUCLEASE 8-LIKE
L720


(Acanthamoeba
polyphaga
mimivirus)
PF06831
(H2TH)
4 TYR A 103
THR A  85
ILE A  91
GLY A  79
None
0.71A 4l39B-4mb7A:
undetectable
4l39B-4mb7A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE


(Serratia
plymuthica)
PF00465
(Fe-ADH)
4 LEU A 211
TYR A 207
ARG A 204
THR A 295
None
0.93A 4l39B-4mcaA:
undetectable
4l39B-4mcaA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mea PREDICTED PROTEIN

(Acinetobacter
nosocomialis)
PF00561
(Abhydrolase_1)
4 LEU A 167
TYR A 154
ILE A 114
GLY A 141
None
0.88A 4l39B-4meaA:
undetectable
4l39B-4meaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o87 N-TAGGED NUCLEASE

(Millerozyma
acaciae)
no annotation 4 LEU A 200
ILE A 268
THR A 183
GLY A 180
None
0.80A 4l39B-4o87A:
undetectable
4l39B-4o87A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oul CAPRIN-2

(Homo sapiens)
PF00386
(C1q)
4 LEU A1123
TYR A1045
THR A1029
GLY A1027
None
0.90A 4l39B-4oulA:
undetectable
4l39B-4oulA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovm UNCHARACTERIZED
PROTEIN SGCJ


(Streptomyces
carzinostaticus)
PF14534
(DUF4440)
4 TYR A 136
ILE A 118
THR A 100
GLY A  83
None
0.76A 4l39B-4ovmA:
undetectable
4l39B-4ovmA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN


(Streptococcus
pyogenes)
PF16569
(GramPos_pilinBB)
4 LEU A 199
THR A 439
ILE A 480
GLY A 456
None
0.96A 4l39B-4p0dA:
undetectable
4l39B-4p0dA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4we6 HEMAGGLUTININ HA1
CHAIN


(Influenza A
virus)
PF00509
(Hemagglutinin)
4 LEU A 154
TYR A 155
ILE A 212
GLY A  94
None
None
None
GOL  A 303 (-3.4A)
0.86A 4l39B-4we6A:
undetectable
4l39B-4we6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE


(Bacillus
licheniformis)
PF01019
(G_glu_transpept)
4 LEU A  60
THR A 405
ILE A 554
GLY A  40
None
0.90A 4l39B-4y23A:
undetectable
4l39B-4y23A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I, RESTRICTION
SUBUNIT


(Escherichia
coli)
PF04851
(ResIII)
4 LEU C 267
TYR C 265
THR C  93
GLY C  89
None
None
None
AMP  C1001 (-3.4A)
0.95A 4l39B-4zcfC:
1.6
4l39B-4zcfC:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B


(Homo sapiens)
PF00229
(TNF)
4 LEU A 269
THR A 285
ILE A 278
GLY A 217
None
0.87A 4l39B-4zchA:
undetectable
4l39B-4zchA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B


(Homo sapiens)
PF00229
(TNF)
4 LEU A 420
THR A 436
ILE A 429
GLY A 368
None
0.88A 4l39B-4zchA:
undetectable
4l39B-4zchA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv4 ELONGATION FACTOR TU

(Pseudomonas
aeruginosa)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
4 LEU A 315
THR A 386
THR A  94
GLY A 390
None
0.92A 4l39B-4zv4A:
1.1
4l39B-4zv4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x REELIN

(Mus musculus)
PF07974
(EGF_2)
4 LEU A2014
ILE A2022
THR A2020
GLY A2130
None
0.82A 4l39B-5b4xA:
undetectable
4l39B-5b4xA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli)
PF07201
(HrpJ)
4 LEU A 167
ILE A 100
THR A  95
GLY A 172
None
0.72A 4l39B-5c9eA:
undetectable
4l39B-5c9eA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE


(Chromohalobacter
salexigens)
PF00120
(Gln-synt_C)
4 ARG A 190
THR A 179
THR A 203
GLY A 205
None
0.87A 4l39B-5dm3A:
undetectable
4l39B-5dm3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE


(Legionella
pneumophila)
PF04389
(Peptidase_M28)
4 LEU A 287
THR A 384
ILE A 136
GLY A 291
None
0.91A 4l39B-5gneA:
undetectable
4l39B-5gneA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
4 LEU A 391
TYR A 382
ARG A 389
GLY A 248
None
0.78A 4l39B-5gnmA:
undetectable
4l39B-5gnmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc8 PRENYLTRANSFERENCE
FOR PROTEIN


(Lavandula
lanata)
PF01255
(Prenyltransf)
4 LEU A 135
TYR A 139
ILE A  75
GLY A  92
61G  A 403 ( 4.5A)
None
None
None
0.92A 4l39B-5hc8A:
undetectable
4l39B-5hc8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA


(Lactobacillus
plantarum)
PF09861
(DUF2088)
4 LEU A 147
ILE A 155
THR A 230
GLY A 145
None
0.96A 4l39B-5huqA:
undetectable
4l39B-5huqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans)
PF01228
(Gly_radical)
PF02901
(PFL-like)
4 TYR A  23
ILE A 812
THR A 824
GLY A 340
None
0.92A 4l39B-5i2gA:
undetectable
4l39B-5i2gA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kan HEMAGGLUTININ HA1

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.92A 4l39B-5kanA:
undetectable
4l39B-5kanA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kia L-THREONINE
3-DEHYDROGENASE


(Burkholderia
thailandensis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 LEU A   4
ILE A  37
THR A  35
GLY A  62
None
0.96A 4l39B-5kiaA:
undetectable
4l39B-5kiaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL


(Homo sapiens)
PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M)
4 LEU A 198
TYR A 116
THR A  96
GLY A  94
None
None
None
FAD  A 901 ( 4.4A)
0.88A 4l39B-5l46A:
undetectable
4l39B-5l46A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL


(Bos taurus)
PF00329
(Complex1_30kDa)
4 LEU C  61
TYR C  94
ILE C 117
GLY C  56
None
0.71A 4l39B-5lc5C:
undetectable
4l39B-5lc5C:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6


(Chaetomium
thermophilum)
PF01912
(eIF-6)
4 LEU A  25
ILE A  92
THR A  20
GLY A  65
None
0.96A 4l39B-5m3qA:
undetectable
4l39B-5m3qA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH


(Eremococcus
coleocola)
PF01566
(Nramp)
4 ARG A 369
THR A 350
ILE A 122
THR A 372
None
0.75A 4l39B-5m8jA:
undetectable
4l39B-5m8jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA


(Methanothermococcus
thermolithotrophicus)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
4 THR B  45
ILE B 422
THR B 203
GLY B 416
None
0.95A 4l39B-5n1qB:
undetectable
4l39B-5n1qB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT


(Methanotorris
formicicus)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
4 THR B  45
ILE B 423
THR B 203
GLY B 417
None
0.96A 4l39B-5n28B:
undetectable
4l39B-5n28B:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE


(Trypanosoma
brucei)
no annotation 4 ARG A 451
THR A 398
ILE A 365
THR A 455
None
0.94A 4l39B-5nfhA:
undetectable
4l39B-5nfhA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tg8 HEMAGGLUTININ HA1
CHAIN


(Influenza A
virus)
PF00509
(Hemagglutinin)
4 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.93A 4l39B-5tg8A:
undetectable
4l39B-5tg8A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr7 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE


(Vibrio cholerae)
PF00768
(Peptidase_S11)
PF07943
(PBP5_C)
4 LEU A 191
TYR A 202
ILE A 125
GLY A  77
None
0.96A 4l39B-5tr7A:
undetectable
4l39B-5tr7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6t HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.91A 4l39B-5w6tA:
undetectable
4l39B-5w6tA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w75 ELONGATION FACTOR TU

(Thermotoga
neapolitana)
no annotation 4 THR A  94
ILE A  61
THR A 383
GLY A 385
None
0.94A 4l39B-5w75A:
0.7
4l39B-5w75A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xl6 HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 LEU A 191
TYR A 192
ILE A 249
GLY A 130
SIA  A 603 (-4.7A)
None
None
SIA  A 603 ( 4.4A)
0.90A 4l39B-5xl6A:
undetectable
4l39B-5xl6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1


(Desulfovibrio
vulgaris;
Homo sapiens)
PF00001
(7tm_1)
PF00258
(Flavodoxin_1)
4 LEU A 286
THR A 201
ILE A 247
GLY A 281
None
0.74A 4l39B-5xraA:
undetectable
4l39B-5xraA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrt -

(-)
no annotation 4 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.92A 4l39B-5xrtA:
undetectable
4l39B-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs9 TETR FAMILY
TRANSCRIPTIONAL
REGULATOR


(Mycolicibacterium
smegmatis)
no annotation 4 LEU A  24
THR A  13
ILE A  58
GLY A  52
None
0.85A 4l39B-5xs9A:
undetectable
4l39B-5xs9A:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S21


(Trichomonas
vaginalis)
PF01249
(Ribosomal_S21e)
4 LEU V  61
TYR V  57
ARG V  22
THR V  20
U  2 890 ( 4.3A)
None
None
None
0.89A 4l39B-5xyiV:
undetectable
4l39B-5xyiV:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD


(Helicobacter
pylori)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
4 THR A 145
ILE A 233
THR A 260
GLY A 265
None
0.92A 4l39B-6apeA:
undetectable
4l39B-6apeA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta)
no annotation 4 LEU A 317
THR A 290
THR A 298
GLY A 287
None
0.91A 4l39B-6bk5A:
undetectable
4l39B-6bk5A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bkp HEMAGGLUTININ

(Influenza A
virus)
no annotation 4 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.84A 4l39B-6bkpA:
undetectable
4l39B-6bkpA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d8w HEMAGGLUTININ

(Influenza A
virus)
no annotation 4 LEU A 193
TYR A 194
ILE A 251
GLY A 133
OXM  A 502 (-4.9A)
None
None
None
0.92A 4l39B-6d8wA:
undetectable
4l39B-6d8wA:
8.09