SIMILAR PATTERNS OF AMINO ACIDS FOR 4L39_A_SALA602_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bkh | MUCONATE LACTONIZINGENZYME (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | LEU A 360ILE A 352THR A 355GLY A 357 | None | 1.01A | 4l39A-1bkhA:1.2 | 4l39A-1bkhA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e2z | CYTOCHROME F (Chlamydomonasreinhardtii) |
PF01333(Apocytochr_F_C)PF16639(Apocytochr_F_N) | 4 | LEU A 100TYR A 102ILE A 49GLY A 72 | NoneNoneNoneHEC A 900 (-3.9A) | 1.02A | 4l39A-1e2zA:undetectable | 4l39A-1e2zA:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gzk | RAC-BETASERINE/THREONINEPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 4 | LEU A 158TYR A 231THR A 292GLY A 295 | None | 1.01A | 4l39A-1gzkA:0.0 | 4l39A-1gzkA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3e | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 4 | LEU A 11TYR A 16ILE A 95THR A 32 | None | 1.03A | 4l39A-1j3eA:undetectable | 4l39A-1j3eA:11.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jsd | HAEMAGGLUTININ (HA1CHAIN) (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 184TYR A 185ILE A 242GLY A 128 | None | 0.89A | 4l39A-1jsdA:0.0 | 4l39A-1jsdA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrr | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 4 | LEU A 76TYR A 81ILE A 160THR A 97 | None | 1.00A | 4l39A-1lrrA:undetectable | 4l39A-1lrrA:12.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oi1 | SCML2 PROTEIN (Homo sapiens) |
PF02820(MBT) | 4 | LEU A 109ILE A 189THR A 233GLY A 90 | None | 0.90A | 4l39A-1oi1A:undetectable | 4l39A-1oi1A:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q90 | APOCYTOCHROME F (Chlamydomonasreinhardtii) |
PF01333(Apocytochr_F_C)PF16639(Apocytochr_F_N) | 4 | LEU A 100TYR A 102ILE A 49GLY A 72 | NoneNoneNoneHEM A 900 (-3.9A) | 0.93A | 4l39A-1q90A:undetectable | 4l39A-1q90A:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qle | CCYTOCHROME COXIDASECYTOCHROME C OXIDASEPOLYPEPTIDE III (Paracoccusdenitrificans) |
PF00510(COX3)PF07835(COX4_pro_2) | 4 | TYR C 8ILE D 16THR C 79GLY D 12 | None | 1.03A | 4l39A-1qleC:0.0 | 4l39A-1qleC:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rty | YVQK PROTEIN (Bacillussubtilis) |
PF01923(Cob_adeno_trans) | 4 | LEU A 93TYR A 152ILE A 40THR A 129 | None | 0.95A | 4l39A-1rtyA:undetectable | 4l39A-1rtyA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ti8 | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 194TYR A 195ILE A 252GLY A 134 | None | 0.96A | 4l39A-1ti8A:undetectable | 4l39A-1ti8A:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v19 | 2-KETO-3-DEOXYGLUCONATE KINASE (Thermusthermophilus) |
PF00294(PfkB) | 4 | TYR A 103ARG A 105ILE A 134GLY A 33 | None | 0.96A | 4l39A-1v19A:1.1 | 4l39A-1v19A:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v19 | 2-KETO-3-DEOXYGLUCONATE KINASE (Thermusthermophilus) |
PF00294(PfkB) | 4 | TYR A 103ARG A 105ILE A 134GLY A 34 | None | 0.91A | 4l39A-1v19A:1.1 | 4l39A-1v19A:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v29 | NITRILE HYDRATASE BCHAIN (Bacillussmithii) |
PF02211(NHase_beta) | 4 | LEU B 206ILE B 217THR B 150GLY B 170 | None | 0.98A | 4l39A-1v29B:undetectable | 4l39A-1v29B:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v76 | RNASE P PROTEINPH1771P (Pyrococcushorikoshii) |
PF01868(UPF0086) | 4 | LEU A 78ARG A 119ILE A 43GLY A 109 | None | 0.94A | 4l39A-1v76A:undetectable | 4l39A-1v76A:9.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xaj | 3-DEHYDROQUINATESYNTHASE (Staphylococcusaureus) |
PF01761(DHQ_synthase) | 4 | LEU A 184TYR A 180ILE A 265GLY A 241 | None | 0.83A | 4l39A-1xajA:undetectable | 4l39A-1xajA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zbm | HYPOTHETICAL PROTEINAF1704 (Archaeoglobusfulgidus) |
PF02621(VitK2_biosynth) | 4 | LEU A 248TYR A 252THR A 105GLY A 175 | None | 0.94A | 4l39A-1zbmA:undetectable | 4l39A-1zbmA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3d | MODULATOR OF DRUGACTIVITY B (Escherichiacoli) |
PF02525(Flavodoxin_2) | 4 | LEU A 199TYR A 195ILE A 17GLY A 41 | None | 0.85A | 4l39A-2b3dA:undetectable | 4l39A-2b3dA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d4w | GLYCEROL KINASE (Cellulomonassp.) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | LEU A 216ILE A 205THR A 191GLY A 137 | None | 1.04A | 4l39A-2d4wA:undetectable | 4l39A-2d4wA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g02 | NISIN BIOSYNTHESISPROTEIN NISC (Lactococcuslactis) |
PF05147(LANC_like) | 4 | LEU A 39TYR A 88ILE A 329GLY A 377 | None | 0.68A | 4l39A-2g02A:undetectable | 4l39A-2g02A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lsu | TPRREPEAT-CONTAININGPROTEIN ASSOCIATEDWITH HSP90 (Saccharomycescerevisiae) |
PF14559(TPR_19) | 4 | TYR A 82ARG A 83ILE A 96GLY A 89 | None | 0.88A | 4l39A-2lsuA:undetectable | 4l39A-2lsuA:12.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p0k | POLYCOMB PROTEINSCMH1 (Homo sapiens) |
PF02820(MBT) | 4 | LEU A 104ILE A 184THR A 228GLY A 85 | None | 0.83A | 4l39A-2p0kA:undetectable | 4l39A-2p0kA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzp | ACYLAMINO-ACID-RELEASING ENZYME (Aeropyrumpernix) |
PF00326(Peptidase_S9) | 4 | LEU A 518ILE A 512THR A 451GLY A 465 | None | 1.03A | 4l39A-2qzpA:undetectable | 4l39A-2qzpA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v73 | PUTATIVEEXO-ALPHA-SIALIDASE (Clostridiumperfringens) |
PF02973(Sialidase) | 4 | LEU A 108TYR A 78ILE A 133GLY A 38 | None | 1.02A | 4l39A-2v73A:undetectable | 4l39A-2v73A:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsk | HEMAGGLUTININ-NEURAMINIDASE (Hendrahenipavirus) |
PF00423(HN) | 4 | LEU A 198TYR A 547ILE A 514GLY A 523 | None | 0.89A | 4l39A-2vskA:undetectable | 4l39A-2vskA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsm | HEMAGGLUTININ-NEURAMINIDASE (Nipahhenipavirus) |
PF00423(HN) | 4 | LEU A 198TYR A 547ILE A 514GLY A 523 | None | 1.00A | 4l39A-2vsmA:undetectable | 4l39A-2vsmA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vwb | PUTATIVEO-SIALOGLYCOPROTEINENDOPEPTIDASE (Methanocaldococcusjannaschii) |
PF00814(Peptidase_M22)PF01163(RIO1) | 4 | ARG A 91ILE A 310THR A 308GLY A 103 | None | 1.01A | 4l39A-2vwbA:undetectable | 4l39A-2vwbA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wrd | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 193TYR A 194ILE A 251GLY A 133 | None | 0.88A | 4l39A-2wrdA:undetectable | 4l39A-2wrdA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y4f | PEROXIDASE YCDB (Escherichiacoli) |
PF04261(Dyp_perox) | 4 | TYR A 317ARG A 175ILE A 363GLY A 365 | NoneSO4 A 400 (-3.9A)NoneNone | 0.97A | 4l39A-2y4fA:undetectable | 4l39A-2y4fA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yp2 | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 194TYR A 195ILE A 252GLY A 134 | None | 0.82A | 4l39A-2yp2A:undetectable | 4l39A-2yp2A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zae | RIBONUCLEASE PPROTEIN COMPONENT 1 (Pyrococcushorikoshii) |
PF01868(UPF0086) | 4 | LEU A 78ARG A 119ILE A 43GLY A 109 | None | 0.93A | 4l39A-2zaeA:undetectable | 4l39A-2zaeA:11.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bs8 | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE (Bacillussubtilis) |
PF00202(Aminotran_3) | 4 | LEU A 394TYR A 383ILE A 337GLY A 358 | None | 0.96A | 4l39A-3bs8A:0.9 | 4l39A-3bs8A:24.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cr3 | PTS-DEPENDENTDIHYDROXYACETONEKINASE, ADP-BINDINGSUBUNIT DHALPTS-DEPENDENTDIHYDROXYACETONEKINASE,PHOSPHOTRANSFERASESUBUNIT DHAM (Lactococcuslactis) |
PF02734(Dak2)PF03610(EIIA-man) | 4 | LEU C 67ILE C 42THR C 44GLY A 77 | NoneNoneNoneADP A1211 (-3.3A) | 0.86A | 4l39A-3cr3C:undetectable | 4l39A-3cr3C:13.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cz8 | PUTATIVESPORULATION-SPECIFICGLYCOSYLASE YDHD (Bacillussubtilis) |
PF00704(Glyco_hydro_18) | 4 | LEU A 198TYR A 133ILE A 151GLY A 206 | None | 1.00A | 4l39A-3cz8A:1.9 | 4l39A-3cz8A:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6k | PUTATIVEAMINOTRANSFERASE (Corynebacteriumdiphtheriae) |
PF12897(Aminotran_MocR) | 4 | LEU A 50ILE A 78THR A 253GLY A 262 | None | 0.96A | 4l39A-3d6kA:undetectable | 4l39A-3d6kA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e0x | LIPASE-ESTERASERELATED PROTEIN (Clostridiumacetobutylicum) |
PF12146(Hydrolase_4) | 4 | LEU A 227TYR A 88ILE A 143GLY A 222 | NoneOXE A 243 (-4.2A)NoneNone | 0.94A | 4l39A-3e0xA:undetectable | 4l39A-3e0xA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eyk | HEMAGGLUTININ HA1CHAIN (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 196TYR A 197ILE A 254GLY A 134 | None | 0.96A | 4l39A-3eykA:undetectable | 4l39A-3eykA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g3o | VACUOLAR TRANSPORTERCHAPERONE 2 (Saccharomycescerevisiae) |
PF09359(VTC) | 4 | LEU A 530TYR A 531ILE A 439GLY A 464 | None | 1.00A | 4l39A-3g3oA:undetectable | 4l39A-3g3oA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gde | DNA LIGASE (Archaeoglobusfulgidus) |
PF01068(DNA_ligase_A_M)PF04675(DNA_ligase_A_N)PF04679(DNA_ligase_A_C) | 4 | LEU A 70TYR A 144ILE A 159GLY A 64 | None | 0.87A | 4l39A-3gdeA:undetectable | 4l39A-3gdeA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lhi | PUTATIVE6-PHOSPHOGLUCONOLACTONASE (Neisseriagonorrhoeae) |
PF01182(Glucosamine_iso) | 4 | LEU A 218ILE A 192THR A 140GLY A 138 | None | 0.84A | 4l39A-3lhiA:undetectable | 4l39A-3lhiA:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lwd | 6-PHOSPHOGLUCONOLACTONASE (Chromohalobactersalexigens) |
PF01182(Glucosamine_iso) | 4 | LEU A 215ILE A 188THR A 138GLY A 136 | None | 0.78A | 4l39A-3lwdA:undetectable | 4l39A-3lwdA:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwt | NUCLEOPROTEIN (Lassamammarenavirus) |
PF00843(Arena_nucleocap)PF17290(Arena_ncap_C) | 4 | LEU A 312TYR A 308ARG A 300GLY A 177 | None | 1.04A | 4l39A-3mwtA:undetectable | 4l39A-3mwtA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o59 | DNA POLYMERASE IILARGE SUBUNIT (Pyrococcushorikoshii) |
PF03833(PolC_DP2) | 4 | LEU X 250TYR X 194THR X 226GLY X 148 | None | 0.91A | 4l39A-3o59X:2.1 | 4l39A-3o59X:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oaj | PUTATIVERING-CLEAVINGDIOXYGENASE MHQO (Bacillussubtilis) |
PF00903(Glyoxalase) | 4 | LEU A 127TYR A 85ILE A 12GLY A 81 | None | 1.00A | 4l39A-3oajA:undetectable | 4l39A-3oajA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ono | RIBOSE/GALACTOSEISOMERASE (Vibrioparahaemolyticus) |
PF02502(LacAB_rpiB)PF12408(DUF3666) | 4 | LEU A 209TYR A 205ILE A 53GLY A 185 | None | 0.97A | 4l39A-3onoA:undetectable | 4l39A-3onoA:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q4d | POSSIBLECHLOROMUCONATECYCLOISOMERASEMANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY (Cytophagahutchinsonii) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | LEU A 323ILE A 334THR A 132GLY A 340 | None | 0.98A | 4l39A-3q4dA:2.6 | 4l39A-3q4dA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q4d | POSSIBLECHLOROMUCONATECYCLOISOMERASEMANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY (Cytophagahutchinsonii) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | LEU A 359TYR A 9ILE A 43GLY A 353 | None | 0.98A | 4l39A-3q4dA:2.6 | 4l39A-3q4dA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qqi | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 194TYR A 195ILE A 252GLY A 134 | NoneNoneNoneEPE A3380 (-3.4A) | 0.82A | 4l39A-3qqiA:undetectable | 4l39A-3qqiA:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r5t | FERRIC VIBRIOBACTINABC TRANSPORTER,PERIPLASMIC FERRICVIBRIOBACTIN-BINDINGPROTEIN (Vibrio cholerae) |
PF01497(Peripla_BP_2) | 4 | LEU A 65ILE A 142THR A 162GLY A 159 | None | 0.93A | 4l39A-3r5tA:undetectable | 4l39A-3r5tA:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT M (Escherichiacoli) |
no annotation | 4 | LEU M 211TYR M 207ILE M 496GLY M 59 | None | 0.86A | 4l39A-3rkoM:1.0 | 4l39A-3rkoM:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4g | NAMN:DMBPHOSPHORIBOSYLTRANSFERASE (Pyrococcushorikoshii) |
no annotation | 4 | LEU A 125ILE A 138THR A 210GLY A 213 | None | 0.94A | 4l39A-3u4gA:1.6 | 4l39A-3u4gA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4j | NAD-DEPENDENTALDEHYDEDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00171(Aldedh) | 4 | LEU A 128ARG A 179ILE A 466GLY A 479 | None | 0.96A | 4l39A-3u4jA:undetectable | 4l39A-3u4jA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a22 | FRUCTOSE-BISPHOSPHATE ALDOLASE (Mycobacteriumtuberculosis) |
PF01116(F_bP_aldolase) | 4 | LEU A 204ILE A 137THR A 182GLY A 163 | None | 1.00A | 4l39A-4a22A:1.6 | 4l39A-4a22A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2b | CELL DIVISIONPROTEIN FTSA,PUTATIVE (Thermotogamaritima) |
PF02491(SHS2_FTSA)PF14450(FtsA) | 4 | LEU A 64ILE A 81THR A 11GLY A 22 | None | 0.72A | 4l39A-4a2bA:undetectable | 4l39A-4a2bA:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c13 | UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--L-LYSINE LIGASE (Staphylococcusaureus) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 4 | TYR A 351ARG A 335THR A 115GLY A 136 | UML A 598 ( 4.3A)PO4 A 601 (-3.9A) MG A 503 ( 3.7A)None | 1.02A | 4l39A-4c13A:undetectable | 4l39A-4c13A:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdg | MINICHROMOSOMEMAINTENANCE PROTEINMCM (Sulfolobussolfataricus) |
no annotation | 4 | LEU B 373ILE B 406THR B 363GLY B 367 | None | 1.02A | 4l39A-4fdgB:undetectable | 4l39A-4fdgB:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hfu | HEMAGGLUTININ HA1 (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 194TYR A 195ILE A 252GLY A 134 | None | 0.96A | 4l39A-4hfuA:undetectable | 4l39A-4hfuA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hkx | HEMAGGLUTININ HA1 (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU E 194TYR E 195ILE E 252GLY E 134 | None | 0.84A | 4l39A-4hkxE:undetectable | 4l39A-4hkxE:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcp | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Brugia malayi) |
PF00160(Pro_isomerase) | 4 | LEU A 69ILE A 12THR A 159GLY A 153 | None | 1.04A | 4l39A-4jcpA:undetectable | 4l39A-4jcpA:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhi | MTN13 PROTEIN (Medicagotruncatula) |
PF00407(Bet_v_1) | 4 | LEU A 90TYR A 133ILE A 98GLY A 87 | NoneEMU A 202 ( 4.3A)EMU A 202 ( 4.9A)None | 0.90A | 4l39A-4jhiA:undetectable | 4l39A-4jhiA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jug | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 194TYR A 195ILE A 252GLY A 134 | None | 0.96A | 4l39A-4jugA:undetectable | 4l39A-4jugA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kw5 | OXIDOREDUCTASE (Mycobacteriumtuberculosis) |
PF01565(FAD_binding_4)PF04030(ALO) | 4 | LEU A 161ARG A 159THR A 153GLY A 182 | None | 1.02A | 4l39A-4kw5A:undetectable | 4l39A-4kw5A:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kwm | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 190TYR A 191ILE A 248GLY A 130 | None | 1.03A | 4l39A-4kwmA:undetectable | 4l39A-4kwmA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mea | PREDICTED PROTEIN (Acinetobacternosocomialis) |
PF00561(Abhydrolase_1) | 4 | LEU A 167TYR A 154ILE A 114GLY A 141 | None | 0.88A | 4l39A-4meaA:undetectable | 4l39A-4meaA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o87 | N-TAGGED NUCLEASE (Millerozymaacaciae) |
no annotation | 4 | LEU A 200ILE A 268THR A 183GLY A 180 | None | 0.76A | 4l39A-4o87A:undetectable | 4l39A-4o87A:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oul | CAPRIN-2 (Homo sapiens) |
PF00386(C1q) | 4 | LEU A1123TYR A1045THR A1029GLY A1027 | None | 0.92A | 4l39A-4oulA:undetectable | 4l39A-4oulA:12.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovm | UNCHARACTERIZEDPROTEIN SGCJ (Streptomycescarzinostaticus) |
PF14534(DUF4440) | 4 | TYR A 136ILE A 118THR A 100GLY A 83 | None | 0.72A | 4l39A-4ovmA:undetectable | 4l39A-4ovmA:13.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r6k | SOLUTE-BINDINGPROTEIN (Bacillussubtilis) |
PF13416(SBP_bac_8) | 4 | LEU A 283ILE A 105THR A 123GLY A 125 | None | 1.02A | 4l39A-4r6kA:undetectable | 4l39A-4r6kA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uwm | 3,6-DIKETOCAMPHANE1,6 MONOOXYGENASE (Pseudomonasputida) |
PF00296(Bac_luciferase) | 4 | LEU A 285TYR A 12ILE A 223THR A 258 | NonePGE A 404 (-4.5A)FMN A 400 ( 4.5A)PGE A 404 (-3.2A) | 0.97A | 4l39A-4uwmA:0.6 | 4l39A-4uwmA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4we6 | HEMAGGLUTININ HA1CHAIN (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 154TYR A 155ILE A 212GLY A 94 | NoneNoneNoneGOL A 303 (-3.4A) | 0.85A | 4l39A-4we6A:undetectable | 4l39A-4we6A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xb6 | ALPHA-D-RIBOSE1-METHYLPHOSPHONATE5-TRIPHOSPHATESYNTHASE SUBUNITPHNI (Escherichiacoli) |
PF05861(PhnI) | 4 | TYR C 124ILE C 105THR C 121GLY C 119 | None | 1.00A | 4l39A-4xb6C:undetectable | 4l39A-4xb6C:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yys | FICIN ISOFORM B (Ficus carica) |
PF00112(Peptidase_C1) | 4 | LEU A 48ILE A 110THR A 38GLY A 36 | None | 1.03A | 4l39A-4yysA:undetectable | 4l39A-4yysA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zcf | RESTRICTIONENDONUCLEASEECOP15I, RESTRICTIONSUBUNIT (Escherichiacoli) |
PF04851(ResIII) | 4 | LEU C 267TYR C 265THR C 93GLY C 89 | NoneNoneNoneAMP C1001 (-3.4A) | 0.97A | 4l39A-4zcfC:undetectable | 4l39A-4zcfC:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b4x | REELIN (Mus musculus) |
PF07974(EGF_2) | 4 | LEU A2014ILE A2022THR A2020GLY A2130 | None | 0.82A | 4l39A-5b4xA:undetectable | 4l39A-5b4xA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c9e | SEPL (Escherichiacoli) |
PF07201(HrpJ) | 4 | LEU A 167ILE A 100THR A 95GLY A 172 | None | 0.76A | 4l39A-5c9eA:1.6 | 4l39A-5c9eA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gj4 | SERINE PROTEASE NS3 (Zika virus) |
PF00949(Peptidase_S7) | 4 | LEU B 58TYR B 79THR B 48GLY B 37 | None | 1.03A | 4l39A-5gj4B:undetectable | 4l39A-5gj4B:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gnm | VITAMIN D(3)25-HYDROXYLASE (Pseudonocardiaautotrophica) |
PF00067(p450) | 4 | LEU A 391TYR A 382ARG A 389GLY A 248 | None | 0.70A | 4l39A-5gnmA:undetectable | 4l39A-5gnmA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hc8 | PRENYLTRANSFERENCEFOR PROTEIN (Lavandulalanata) |
PF01255(Prenyltransf) | 4 | LEU A 135TYR A 139ILE A 75GLY A 92 | 61G A 403 ( 4.5A)NoneNoneNone | 0.94A | 4l39A-5hc8A:undetectable | 4l39A-5hc8A:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5huq | LACTATE RACEMIZATIONOPERON PROTEIN LARA (Lactobacillusplantarum) |
PF09861(DUF2088) | 4 | LEU A 147ILE A 155THR A 230GLY A 145 | None | 0.99A | 4l39A-5huqA:undetectable | 4l39A-5huqA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2g | DIOL DEHYDRATASE (Roseburiainulinivorans) |
PF01228(Gly_radical)PF02901(PFL-like) | 4 | TYR A 23ILE A 812THR A 824GLY A 340 | None | 0.92A | 4l39A-5i2gA:undetectable | 4l39A-5i2gA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k82 | APOLIPOPROTEIN BMRNA EDITING ENZYME,CATALYTICPEPTIDE-LIKE3G,APOLIPOPROTEIN BMRNA EDITING ENZYME,CATALYTICPEPTIDE-LIKE 3G (Macaca mulatta) |
PF08210(APOBEC_N) | 4 | LEU A 135ILE A 151THR A 188GLY A 190 | None | 0.99A | 4l39A-5k82A:undetectable | 4l39A-5k82A:15.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kan | HEMAGGLUTININ HA1 (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 194TYR A 195ILE A 252GLY A 134 | None | 0.92A | 4l39A-5kanA:undetectable | 4l39A-5kanA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kia | L-THREONINE3-DEHYDROGENASE (Burkholderiathailandensis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | LEU A 4ILE A 37THR A 35GLY A 62 | None | 0.94A | 4l39A-5kiaA:undetectable | 4l39A-5kiaA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l46 | DIMETHYLGLYCINEDEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF01266(DAO)PF01571(GCV_T)PF08669(GCV_T_C)PF16350(FAO_M) | 4 | LEU A 198TYR A 116THR A 96GLY A 94 | NoneNoneNoneFAD A 901 ( 4.4A) | 0.91A | 4l39A-5l46A:undetectable | 4l39A-5l46A:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lc5 | NADH DEHYDROGENASE[UBIQUINONE]IRON-SULFUR PROTEIN3, MITOCHONDRIAL (Bos taurus) |
PF00329(Complex1_30kDa) | 4 | LEU C 61TYR C 94ILE C 117GLY C 56 | None | 0.71A | 4l39A-5lc5C:undetectable | 4l39A-5lc5C:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m3q | EUKARYOTICTRANSLATIONINITIATION FACTOR 6 (Chaetomiumthermophilum) |
PF01912(eIF-6) | 4 | LEU A 25ILE A 92THR A 20GLY A 65 | None | 0.93A | 4l39A-5m3qA:undetectable | 4l39A-5m3qA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tg8 | HEMAGGLUTININ HA1CHAIN (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 194TYR A 195ILE A 252GLY A 134 | None | 0.94A | 4l39A-5tg8A:undetectable | 4l39A-5tg8A:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tr7 | D-ALANYL-D-ALANINECARBOXYPEPTIDASE (Vibrio cholerae) |
PF00768(Peptidase_S11)PF07943(PBP5_C) | 4 | LEU A 191TYR A 202ILE A 125GLY A 77 | None | 1.00A | 4l39A-5tr7A:undetectable | 4l39A-5tr7A:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5umn | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 194TYR A 195ILE A 252GLY A 134 | None | 0.98A | 4l39A-5umnA:undetectable | 4l39A-5umnA:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w6t | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 194TYR A 195ILE A 252GLY A 134 | None | 0.91A | 4l39A-5w6tA:undetectable | 4l39A-5w6tA:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgw | ISOASPARTYLDIPEPTIDASE (Colwelliapsychrerythraea) |
no annotation | 4 | LEU A 339ILE A 372THR A 64GLY A 66 | None | 0.99A | 4l39A-5xgwA:0.8 | 4l39A-5xgwA:9.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xl2 | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 191TYR A 192ILE A 249GLY A 130 | None | 0.97A | 4l39A-5xl2A:undetectable | 4l39A-5xl2A:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xl6 | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 191TYR A 192ILE A 249GLY A 130 | SIA A 603 (-4.7A)NoneNoneSIA A 603 ( 4.4A) | 0.91A | 4l39A-5xl6A:undetectable | 4l39A-5xl6A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xrt | - (-) |
no annotation | 4 | LEU A 194TYR A 195ILE A 252GLY A 134 | None | 0.92A | 4l39A-5xrtA:undetectable | 4l39A-5xrtA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | 40S RIBOSOMALPROTEIN S21 (Trichomonasvaginalis) |
PF01249(Ribosomal_S21e) | 4 | LEU V 61TYR V 57ARG V 22THR V 20 | U 2 890 ( 4.3A)NoneNoneNone | 0.87A | 4l39A-5xyiV:undetectable | 4l39A-5xyiV:9.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b8s | DIHYDROOROTATEDEHYDROGENASE(QUINONE) (Helicobacterpylori) |
no annotation | 4 | LEU A 76TYR A 138ILE A 171GLY A 143 | None | 1.03A | 4l39A-6b8sA:1.2 | 4l39A-6b8sA:8.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bkp | HEMAGGLUTININ (Influenza Avirus) |
no annotation | 4 | LEU A 194TYR A 195ILE A 252GLY A 134 | None | 0.85A | 4l39A-6bkpA:undetectable | 4l39A-6bkpA:11.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d8w | HEMAGGLUTININ (Influenza Avirus) |
no annotation | 4 | LEU A 193TYR A 194ILE A 251GLY A 133 | OXM A 502 (-4.9A)NoneNoneNone | 0.93A | 4l39A-6d8wA:undetectable | 4l39A-6d8wA:8.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f34 | AMINO ACIDTRANSPORTER (Geobacilluskaustophilus) |
no annotation | 4 | LEU A 112TYR A 116ILE A 234GLY A 382 | NoneARG A 501 (-3.9A)ARG A 501 (-3.7A)None | 0.99A | 4l39A-6f34A:undetectable | 4l39A-6f34A:9.52 |