SIMILAR PATTERNS OF AMINO ACIDS FOR 4L1X_A_STRA402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR

(Homo sapiens) 		PF01858
(RB_A) 		4 LEU A 486
TYR A 453
VAL A 531
LEU A 461
 None
 1.00A 4l1xA-1ad6A:
undetectable		 4l1xA-1ad6A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsf THYMIDYLATE SYNTHASE
A

(Bacillus
subtilis) 		PF00303
(Thymidylat_synt) 		4 LEU A 176
VAL A 178
LEU A 131
LEU A 130
 None
 0.91A 4l1xA-1bsfA:
undetectable		 4l1xA-1bsfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gdh D-GLYCERATE
DEHYDROGENASE

(Hyphomicrobium
methylovorum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 209
VAL A 244
LEU A 200
LEU A 197
 None
 0.96A 4l1xA-1gdhA:
1.6		 4l1xA-1gdhA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		4 LEU B 486
TYR B 453
VAL B 531
LEU B 461
 None
 1.02A 4l1xA-1gh6B:
undetectable		 4l1xA-1gh6B:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 LEU A 290
VAL A 313
HIS A 298
LEU A 127
 None
 0.81A 4l1xA-1idmA:
0.1		 4l1xA-1idmA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		4 LEU A 249
TYR A 251
LEU A 282
LEU A 287
 None
 1.03A 4l1xA-1j1uA:
0.4		 4l1xA-1j1uA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgs DNA BINDING RESPONSE
REGULATOR D

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 LEU A  22
VAL A  29
LEU A 101
LEU A  78
 None
 0.95A 4l1xA-1kgsA:
1.2		 4l1xA-1kgsA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A 391
VAL A 228
LEU A 207
LEU A 240
 None
 0.95A 4l1xA-1lxtA:
0.5		 4l1xA-1lxtA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF01380
(SIS) 		4 LEU A 389
VAL A 411
LEU A 288
LEU A 289
 None
 0.87A 4l1xA-1morA:
0.9		 4l1xA-1morA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 LEU A 382
VAL A 506
LEU A 332
LEU A 517
 None
 0.91A 4l1xA-1nneA:
undetectable		 4l1xA-1nneA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrz PLASMINOGEN

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A 649
VAL A 787
LEU A 755
LEU A 667
 None
 0.93A 4l1xA-1qrzA:
undetectable		 4l1xA-1qrzA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0i YLR011WP

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		4 LEU A 136
TYR A  99
VAL A 121
LEU A 143
 None
 0.95A 4l1xA-1t0iA:
undetectable		 4l1xA-1t0iA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tye INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 LEU B 368
VAL B 359
LEU B  92
LEU B  90
 None
 0.67A 4l1xA-1tyeB:
undetectable		 4l1xA-1tyeB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 LEU A 142
VAL A 188
LEU A 498
LEU A 196
 None
 1.03A 4l1xA-1upxA:
undetectable		 4l1xA-1upxA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE

(Thermus
thermophilus) 		PF00697
(PRAI) 		4 LEU A 105
TYR A 134
LEU A 166
LEU A 143
 None
 0.83A 4l1xA-1v5xA:
11.2		 4l1xA-1v5xA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU A 258
TYR A 272
VAL A 160
LEU A 295
 None
 0.97A 4l1xA-1vc2A:
undetectable		 4l1xA-1vc2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		4 LEU A  41
VAL A 397
LEU A 425
LEU A 430
 None
 0.97A 4l1xA-2e4uA:
1.9		 4l1xA-2e4uA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsz TWITCHING MOTILITY
PROTEIN PILT

(Aquifex
aeolicus) 		PF00437
(T2SSE) 		4 LEU A 228
VAL A 268
LEU A 241
LEU A 140
 None
 0.96A 4l1xA-2gszA:
undetectable		 4l1xA-2gszA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hje AUTOINDUCER 2 SENSOR
KINASE/PHOSPHATASE
LUXQ

(Vibrio harveyi) 		PF09308
(LuxQ-periplasm) 		4 LEU A 266
VAL A 211
LEU A 168
LEU A 192
 None
 0.95A 4l1xA-2hjeA:
undetectable		 4l1xA-2hjeA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		4 LEU A  53
VAL A  83
LEU A 112
LEU A 116
 None
 0.88A 4l1xA-2i44A:
undetectable		 4l1xA-2i44A:
23.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 TYR A  55
VAL A 128
HIS A 222
LEU A 308
 FFA  A 325 ( 4.3A)
None
NAP  A   1 ( 4.8A)
FFA  A 325 (-4.5A)
 0.47A 4l1xA-2ipjA:
56.2		 4l1xA-2ipjA:
98.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 TYR A  55
VAL A 128
HIS A 222
TRP A 227
 FFA  A 325 ( 4.3A)
None
NAP  A   1 ( 4.8A)
FFA  A 325 (-3.8A)
 0.76A 4l1xA-2ipjA:
56.2		 4l1xA-2ipjA:
98.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		4 LEU A 389
VAL A 411
LEU A 288
LEU A 289
 None
 0.89A 4l1xA-2j6hA:
undetectable		 4l1xA-2j6hA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kk6 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FER

(Homo sapiens) 		PF00017
(SH2) 		4 LEU A  53
HIS A  21
LEU A  32
LEU A  33
 None
 0.91A 4l1xA-2kk6A:
undetectable		 4l1xA-2kk6A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lev LER

(Escherichia
coli) 		PF00816
(Histone_HNS) 		4 LEU A  40
VAL A   6
LEU A  30
LEU A  26
 None
 0.78A 4l1xA-2levA:
undetectable		 4l1xA-2levA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		4 LEU C 240
VAL C  92
LEU C 211
LEU C 172
 None
 0.96A 4l1xA-2nn3C:
undetectable		 4l1xA-2nn3C:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odh R.BCNI

(Brevibacillus
centrosporus) 		PF15515
(MvaI_BcnI) 		4 LEU A  61
VAL A  46
LEU A 237
LEU A  13
 None
 0.77A 4l1xA-2odhA:
undetectable		 4l1xA-2odhA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		4 LEU A  63
VAL A  65
LEU A  85
LEU A 130
 None
NAD  A1780 (-3.6A)
None
None
 1.00A 4l1xA-2pd3A:
undetectable		 4l1xA-2pd3A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1g CADMUS

(Drosophila
melanogaster) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		4 LEU F 190
TYR F 189
VAL F 233
LEU F 260
 None
 1.00A 4l1xA-2x1gF:
undetectable		 4l1xA-2x1gF:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 LEU A 439
TYR A 377
LEU A 410
LEU A 432
 None
 1.00A 4l1xA-2xt6A:
undetectable		 4l1xA-2xt6A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3j ENHANCER OF
MRNA-DECAPPING
PROTEIN 3

(Homo sapiens) 		PF03853
(YjeF_N)
PF09532
(FDF) 		4 LEU A 357
VAL A 364
LEU A 459
LEU A 440
 None
 0.97A 4l1xA-3d3jA:
undetectable		 4l1xA-3d3jA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3k ENHANCER OF
MRNA-DECAPPING
PROTEIN 3

(Homo sapiens) 		PF03853
(YjeF_N) 		4 LEU A 357
VAL A 364
LEU A 459
LEU A 440
 None
 1.02A 4l1xA-3d3kA:
undetectable		 4l1xA-3d3kA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		4 LEU A 152
TYR A  41
LEU A  75
LEU A  77
 None
 1.02A 4l1xA-3d8nA:
undetectable		 4l1xA-3d8nA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eat PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCB

(Pseudomonas
aeruginosa) 		PF02668
(TauD) 		4 LEU X  55
VAL X 250
HIS X 239
LEU X 109
 None
 1.02A 4l1xA-3eatX:
undetectable		 4l1xA-3eatX:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE

(Legionella
pneumophila) 		PF13523
(Acetyltransf_8) 		4 TYR A  75
LEU A  26
LEU A  38
LEU A  43
 None
 1.01A 4l1xA-3f5bA:
undetectable		 4l1xA-3f5bA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		PF04775
(Bile_Hydr_Trans)
PF08840
(BAAT_C) 		4 LEU A 277
TYR A 276
VAL A 288
LEU A 212
 None
 1.00A 4l1xA-3hlkA:
undetectable		 4l1xA-3hlkA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus) 		PF00901
(Orbi_VP5) 		4 LEU D 258
TYR D 158
VAL D 130
LEU D 237
 None
 0.95A 4l1xA-3j9eD:
undetectable		 4l1xA-3j9eD:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 4 LEU K 931
VAL K 960
LEU K 909
LEU K 939
 None
 0.96A 4l1xA-3jblK:
undetectable		 4l1xA-3jblK:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A 127
TYR A 110
LEU A  62
LEU A  79
 None
 0.90A 4l1xA-3kq0A:
undetectable		 4l1xA-3kq0A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5y SENSOR PROTEIN

(Bacillus
halodurans) 		PF13492
(GAF_3) 		4 LEU A  65
TYR A  66
LEU A  98
LEU A  80
 None
ACT  A   2 (-4.6A)
None
None
 0.83A 4l1xA-3o5yA:
undetectable		 4l1xA-3o5yA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		4 LEU A  44
VAL A  39
LEU A  96
LEU A  92
 None
 0.94A 4l1xA-3ojaA:
undetectable		 4l1xA-3ojaA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 TYR A 255
LEU A 349
VAL A  22
HIS A 253
 None
 0.84A 4l1xA-3oytA:
undetectable		 4l1xA-3oytA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 476
TYR A 475
VAL A 498
LEU A 402
 None
 1.01A 4l1xA-3p5pA:
undetectable		 4l1xA-3p5pA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3j PLEXIN-A2

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		4 LEU A1565
VAL A1563
LEU A1500
LEU A1502
 None
 0.97A 4l1xA-3q3jA:
undetectable		 4l1xA-3q3jA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 LEU A 595
TYR A 564
LEU A 580
LEU A 601
 None
 0.91A 4l1xA-3syjA:
undetectable		 4l1xA-3syjA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A4084
VAL A4027
LEU A4430
LEU A3992
 None
 1.02A 4l1xA-3vkgA:
undetectable		 4l1xA-3vkgA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdg URACIL-DNA
GLYCOSYLASE

(Staphylococcus
aureus) 		PF03167
(UDG) 		4 TYR A 196
VAL A 153
LEU A 104
LEU A 114
 None
 0.95A 4l1xA-3wdgA:
undetectable		 4l1xA-3wdgA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo9 VARIABLE LYMPHOCYTE
RECEPTOR C

(Lethenteron
camtschaticum) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU A 208
VAL A 234
LEU A 167
LEU A 191
 None
 0.76A 4l1xA-3wo9A:
undetectable		 4l1xA-3wo9A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwn PUTATIVE
ACETYLGLUTAMATE
KINASE-LIKE PROTEIN

(Thermus
thermophilus) 		PF00696
(AA_kinase) 		4 LEU A  31
VAL A  29
LEU A  86
LEU A  90
 None
 1.00A 4l1xA-3wwnA:
undetectable		 4l1xA-3wwnA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhp CALCIUM-BINDING
PROTEIN 39-LIKE

(Homo sapiens) 		PF08569
(Mo25) 		4 TYR A 118
LEU A  73
TYR A  74
VAL A  18
 None
 0.97A 4l1xA-3zhpA:
undetectable		 4l1xA-3zhpA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyt ESTERASE A

(Paenarthrobacter
nitroguajacolicus) 		PF00144
(Beta-lactamase) 		4 LEU A 359
TYR A 342
VAL A  13
LEU A  21
 None
 1.00A 4l1xA-3zytA:
undetectable		 4l1xA-3zytA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bax GLUTAMINE SYNTHETASE

(Streptomyces
coelicolor) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 LEU A  25
TYR A 210
HIS A 163
LEU A 202
 None
NA  A1351 ( 4.1A)
None
None
 0.92A 4l1xA-4baxA:
undetectable		 4l1xA-4baxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 LEU A1044
VAL A 842
LEU A 860
LEU A 916
 None
 0.96A 4l1xA-4bedA:
undetectable		 4l1xA-4bedA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		4 LEU A 151
TYR A 152
VAL A 141
LEU A 118
 None
 0.82A 4l1xA-4eelA:
undetectable		 4l1xA-4eelA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo0 ACTIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF00022
(Actin) 		4 LEU A 172
TYR A 173
VAL A  74
HIS A 369
 None
GOL  A 704 (-4.0A)
None
None
 1.00A 4l1xA-4fo0A:
undetectable		 4l1xA-4fo0A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8s NITROREDUCTASE
FAMILY PROTEIN

(Geobacter
sulfurreducens) 		PF00881
(Nitroreductase) 		4 LEU A  30
VAL A 181
LEU A 128
LEU A 159
 None
 0.98A 4l1xA-4g8sA:
undetectable		 4l1xA-4g8sA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 487
VAL A 338
LEU A 368
LEU A 372
 None
 0.96A 4l1xA-4gl2A:
undetectable		 4l1xA-4gl2A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gw9 BACTERIOPHYTOCHROME

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF00989
(PAS)
PF01590
(GAF)
PF08446
(PAS_2) 		4 LEU A 271
VAL A 281
LEU A 313
LEU A 147
 None
 0.98A 4l1xA-4gw9A:
undetectable		 4l1xA-4gw9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2d NADPH-DEPENDENT
DIFLAVIN
OXIDOREDUCTASE 1

(Homo sapiens) 		PF00258
(Flavodoxin_1) 		4 LEU A 112
VAL A  94
LEU A  82
LEU A 119
 None
 0.97A 4l1xA-4h2dA:
undetectable		 4l1xA-4h2dA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		4 TYR A 159
LEU A 336
TYR A 335
VAL A 316
 HEM  A 401 (-4.4A)
HEM  A 401 (-4.5A)
HEM  A 401 (-4.5A)
HEM  A 401 (-3.9A)
 1.02A 4l1xA-4hkaA:
undetectable		 4l1xA-4hkaA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvm TLMII

(Streptoalloteichus
hindustanus) 		PF00668
(Condensation) 		4 LEU A 121
VAL A 154
LEU A 141
LEU A 142
 None
 0.96A 4l1xA-4hvmA:
undetectable		 4l1xA-4hvmA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		no annotation 4 LEU A  68
VAL A  51
LEU A  23
LEU A  75
 None
 1.02A 4l1xA-4i0wA:
undetectable		 4l1xA-4i0wA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		4 TYR A 118
VAL A 194
LEU A 143
LEU A 146
 None
 0.93A 4l1xA-4i59A:
undetectable		 4l1xA-4i59A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		4 TYR A 507
VAL A  62
LEU A 548
LEU A 542
 None
 0.89A 4l1xA-4iv9A:
undetectable		 4l1xA-4iv9A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 LEU A 344
VAL A  57
LEU A 103
LEU A  99
 None
 0.99A 4l1xA-4je5A:
undetectable		 4l1xA-4je5A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		4 LEU A 223
VAL A 241
LEU A 228
LEU A 230
 None
 0.72A 4l1xA-4k17A:
undetectable		 4l1xA-4k17A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		4 LEU A 401
VAL A 276
LEU A 105
LEU A 366
 None
 0.92A 4l1xA-4m8jA:
undetectable		 4l1xA-4m8jA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnm CHITINASE A

(Cycas revoluta) 		PF00704
(Glyco_hydro_18) 		4 LEU A  37
VAL A  81
LEU A 137
LEU A 133
 SO4  A 404 (-4.0A)
SO4  A 404 (-3.7A)
None
None
 0.89A 4l1xA-4mnmA:
9.5		 4l1xA-4mnmA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 CALCIUM-BINDING
PROTEIN 39

(Homo sapiens) 		PF08569
(Mo25) 		4 TYR A 119
LEU A  74
TYR A  75
VAL A  16
 None
 0.91A 4l1xA-4o27A:
undetectable		 4l1xA-4o27A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p62 METALLO-BETA-LACTAMA
SE AIM-1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 LEU A  61
VAL A 247
LEU A 172
LEU A 174
 None
 0.95A 4l1xA-4p62A:
undetectable		 4l1xA-4p62A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po4 LAMPETRA PLANERI
VLRC

(Lampetra
planeri) 		PF13855
(LRR_8) 		4 LEU A 182
VAL A 208
LEU A 141
LEU A 165
 None
 0.81A 4l1xA-4po4A:
undetectable		 4l1xA-4po4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIM

(Thermotoga
maritima) 		PF02154
(FliM) 		4 LEU A 227
HIS A  59
LEU A 196
LEU A 219
 None
 0.95A 4l1xA-4qrmA:
undetectable		 4l1xA-4qrmA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIM

(Thermotoga
maritima) 		PF02154
(FliM) 		4 VAL A 109
HIS A  59
LEU A 196
LEU A 219
 None
 0.93A 4l1xA-4qrmA:
undetectable		 4l1xA-4qrmA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13581
(HATPase_c_2) 		4 TYR A 204
VAL A 278
LEU A 148
LEU A 307
 None
 1.02A 4l1xA-4r39A:
undetectable		 4l1xA-4r39A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvo MALATE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  22
VAL A  11
LEU A 160
LEU A 157
 None
None
NA  A 403 (-4.4A)
None
 0.88A 4l1xA-4tvoA:
undetectable		 4l1xA-4tvoA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		4 LEU B 363
VAL B 365
LEU B 433
LEU B 418
 None
 0.98A 4l1xA-4tx2B:
undetectable		 4l1xA-4tx2B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtb CALCIUM UNIPORTER
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 LEU A 151
VAL A 125
LEU A 145
LEU A 144
 None
 1.00A 4l1xA-4xtbA:
undetectable		 4l1xA-4xtbA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yac C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 LEU A  26
VAL A  34
LEU A 185
LEU A 140
 None
 0.99A 4l1xA-4yacA:
undetectable		 4l1xA-4yacA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a78 DNA ENDONUCLEASE
I-CVUI

(Chlorella
vulgaris) 		PF00961
(LAGLIDADG_1) 		4 LEU A  88
VAL A 109
LEU A  16
LEU A  95
 None
 0.96A 4l1xA-5a78A:
undetectable		 4l1xA-5a78A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		4 TYR A 405
LEU A 387
VAL A 520
LEU A 347
 None
 0.95A 4l1xA-5e26A:
undetectable		 4l1xA-5e26A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl3 LMO2470 PROTEIN

(Listeria
monocytogenes) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 LEU A 269
VAL A 283
LEU A 231
LEU A 253
 None
 0.96A 4l1xA-5hl3A:
undetectable		 4l1xA-5hl3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 4 LEU B 235
VAL B 216
LEU B 291
LEU B 259
 None
 1.01A 4l1xA-5hzgB:
undetectable		 4l1xA-5hzgB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU A 528
VAL A 543
LEU A 511
LEU A 535
 None
 0.98A 4l1xA-5ixqA:
undetectable		 4l1xA-5ixqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 VAL A 561
HIS A 545
LEU A 578
LEU A 582
 None
 0.98A 4l1xA-5ju6A:
3.0		 4l1xA-5ju6A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 LEU A 247
VAL A 261
LEU A 209
LEU A 231
 None
 0.98A 4l1xA-5kzsA:
undetectable		 4l1xA-5kzsA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Bos taurus) 		PF00146
(NADHdh)
PF00346
(Complex1_49kDa) 		4 TYR H 127
VAL D 415
LEU D  47
LEU D  68
 None
 0.96A 4l1xA-5lc5H:
undetectable		 4l1xA-5lc5H:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  19
VAL A   8
LEU A 157
LEU A 154
 None
None
NAD  A 334 (-4.1A)
NAD  A 334 (-4.1A)
 0.87A 4l1xA-5mdhA:
undetectable		 4l1xA-5mdhA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlv -

(-) 		no annotation 4 LEU G 445
TYR G 153
VAL G 110
LEU G 438
 None
 1.00A 4l1xA-5mlvG:
undetectable		 4l1xA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlv -

(-) 		no annotation 4 LEU G 445
TYR G 153
VAL G 429
LEU G 438
 None
 0.99A 4l1xA-5mlvG:
undetectable		 4l1xA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nue MALATE DEHYDROGENASE
1, CYTOPLASMIC

(Arabidopsis
thaliana) 		no annotation 4 LEU A  21
VAL A  10
LEU A 159
LEU A 156
 None
None
NAD  A 401 ( 4.2A)
NAD  A 401 (-4.2A)
 0.88A 4l1xA-5nueA:
undetectable		 4l1xA-5nueA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7o NOSK

(Streptomyces
actuosus) 		PF12697
(Abhydrolase_6) 		4 LEU A  38
VAL A 173
LEU A 154
LEU A 147
 None
 0.81A 4l1xA-5v7oA:
undetectable		 4l1xA-5v7oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v89 DCN1-LIKE PROTEIN 4

(Homo sapiens) 		PF03556
(Cullin_binding) 		4 LEU A 224
TYR A 197
VAL A 139
LEU A 212
 None
 1.01A 4l1xA-5v89A:
undetectable		 4l1xA-5v89A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 LEU A 469
TYR A 468
VAL A 420
HIS A 318
 None
 0.85A 4l1xA-5vocA:
undetectable		 4l1xA-5vocA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 TYR A  37
LEU A  29
VAL A  16
LEU A 126
 None
 0.93A 4l1xA-5wu7A:
3.3		 4l1xA-5wu7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		4 TYR A 496
TYR A 541
VAL A 617
LEU A 599
 None
 0.82A 4l1xA-5wzrA:
7.7		 4l1xA-5wzrA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 4 TYR A 173
LEU A 226
LEU A 201
LEU A 222
 None
 0.84A 4l1xA-5y3jA:
undetectable		 4l1xA-5y3jA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		4 VAL A 638
HIS A 468
LEU A 460
LEU A 451
 None
 0.97A 4l1xA-5y7oA:
undetectable		 4l1xA-5y7oA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 4 LEU A   8
VAL A 263
LEU A 315
LEU A 316
 None
 0.98A 4l1xA-6bs7A:
undetectable		 4l1xA-6bs7A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 4 LEU A 206
VAL A 164
LEU A  79
LEU A  64
 None
 0.92A 4l1xA-6c4gA:
undetectable		 4l1xA-6c4gA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 LEU A 262
VAL A 245
LEU A 298
LEU A 284
 None
 0.96A 4l1xA-6evgA:
undetectable		 4l1xA-6evgA:
12.38