SIMILAR PATTERNS OF AMINO ACIDS FOR 4L1W_B_STRB402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A  83
VAL A  73
ILE A  38
LEU A  92
 None
 0.81A 4l1wB-1d1tA:
undetectable		 4l1wB-1d1tA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee2 ALCOHOL
DEHYDROGENASE

(Equus caballus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A  83
VAL A  73
ILE A  38
LEU A  92
 None
 0.87A 4l1wB-1ee2A:
undetectable		 4l1wB-1ee2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE

(Streptomyces
clavuligerus) 		PF00491
(Arginase) 		4 VAL A 230
VAL A 225
ILE A 221
LEU A 264
 None
 0.98A 4l1wB-1gq7A:
undetectable		 4l1wB-1gq7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 VAL A 399
VAL A 383
ILE A 331
LEU A 347
 None
 0.93A 4l1wB-1httA:
undetectable		 4l1wB-1httA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iip CYCLOPHILIN 40

(Bos taurus) 		PF00160
(Pro_isomerase)
PF13176
(TPR_7) 		4 VAL A 152
ILE A 153
TRP A 190
LEU A 184
 None
 0.74A 4l1wB-1iipA:
undetectable		 4l1wB-1iipA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jq0 GP41 ENVELOPE
PROTEIN

(Simian
immunodeficiency
virus) 		no annotation 4 VAL A  54
VAL A  29
ILE A  32
TRP A  47
 None
 0.81A 4l1wB-1jq0A:
undetectable		 4l1wB-1jq0A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jye LACTOSE OPERON
REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 VAL A  94
VAL A  66
ILE A 123
LEU A 305
 None
 0.90A 4l1wB-1jyeA:
undetectable		 4l1wB-1jyeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		4 VAL A 113
VAL A 214
ILE A 243
LEU A 270
 None
 0.94A 4l1wB-1lmlA:
undetectable		 4l1wB-1lmlA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7h ADENYLYLSULFATE
KINASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase) 		4 VAL A 180
VAL A 134
ILE A  28
LEU A  41
 None
 0.97A 4l1wB-1m7hA:
undetectable		 4l1wB-1m7hA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A1083
VAL A1073
ILE A1038
LEU A1092
 None
 0.90A 4l1wB-1p0cA:
undetectable		 4l1wB-1p0cA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz9 REP PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF08724
(Rep_N) 		4 VAL A   7
VAL A 108
ILE A 111
LEU A  64
 None
 0.88A 4l1wB-1rz9A:
undetectable		 4l1wB-1rz9A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 VAL A  94
VAL A  66
ILE A 123
LEU A 305
 None
 0.91A 4l1wB-1tlfA:
undetectable		 4l1wB-1tlfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR

(Caenorhabditis
elegans) 		PF01833
(TIG)
PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		4 VAL A 455
VAL A 449
ILE A 386
LEU A 394
 None
 0.99A 4l1wB-1ttuA:
undetectable		 4l1wB-1ttuA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
ARP2/3 COMPLEX 20KDA
SUBUNIT

(Bos taurus) 		PF04699
(P16-Arc)
PF05856
(ARPC4) 		4 VAL F  51
VAL G 144
ILE G 141
LEU F  16
 None
 0.96A 4l1wB-1u2vF:
undetectable		 4l1wB-1u2vF:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A  83
VAL A  73
ILE A  38
LEU A  92
 None
 0.80A 4l1wB-1u3tA:
undetectable		 4l1wB-1u3tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw4 UPF3X

(Homo sapiens) 		PF03467
(Smg4_UPF3) 		4 VAL A 131
VAL A  53
ILE A  99
LEU A  67
 None
 0.92A 4l1wB-1uw4A:
undetectable		 4l1wB-1uw4A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5n HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		4 VAL A  57
VAL A  19
ILE A  93
LEU A  23
 None
 0.85A 4l1wB-1x5nA:
undetectable		 4l1wB-1x5nA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm7 HYPOTHETICAL PROTEIN
AQ_1665

(Aquifex
aeolicus) 		PF12850
(Metallophos_2) 		4 VAL A 169
ILE A   5
TRP A  65
LEU A  74
 None
 0.85A 4l1wB-1xm7A:
undetectable		 4l1wB-1xm7A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xre SUPEROXIDE DISMUTASE

(Bacillus
anthracis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 VAL A 195
VAL A 102
ILE A 106
LEU A 120
 None
 0.78A 4l1wB-1xreA:
undetectable		 4l1wB-1xreA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Escherichia
coli) 		PF08534
(Redoxin) 		4 VAL E 101
VAL E  71
ILE E 149
LEU E 138
 None
 0.99A 4l1wB-1z5yE:
undetectable		 4l1wB-1z5yE:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4m GLYCINE
BETAINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		4 VAL A 149
VAL A 187
ILE A 188
LEU A 195
 None
 1.00A 4l1wB-2b4mA:
undetectable		 4l1wB-2b4mA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjs ISOPENICILLIN N
SYNTHETASE

(Aspergillus
nidulans) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 TYR A 146
VAL A 149
VAL A 222
LEU A 186
 None
 0.93A 4l1wB-2bjsA:
undetectable		 4l1wB-2bjsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE

(Plasmodium
falciparum) 		PF01048
(PNP_UDP_1) 		4 VAL A 134
VAL A  85
ILE A  86
LEU A 185
 None
 0.92A 4l1wB-2bsxA:
undetectable		 4l1wB-2bsxA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ek6 RNA-BINDING PROTEIN
12

(Homo sapiens) 		PF00076
(RRM_1) 		4 VAL A  18
VAL A  85
ILE A  80
LEU A  31
 None
 1.00A 4l1wB-2ek6A:
undetectable		 4l1wB-2ek6A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z PROTEIN (CHEMOTAXIS
METHYLATION PROTEIN)

(Thermotoga
maritima) 		PF03975
(CheD) 		4 TYR C 134
VAL C  30
ILE C 117
LEU C  72
 None
 0.96A 4l1wB-2f9zC:
undetectable		 4l1wB-2f9zC:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjl 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
GAMMA 1

(Rattus
norvegicus) 		PF00169
(PH) 		4 VAL A 146
VAL A  95
ILE A  29
TRP A 139
 None
 0.87A 4l1wB-2fjlA:
undetectable		 4l1wB-2fjlA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0f THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Escherichia
coli) 		PF08534
(Redoxin) 		4 VAL A 101
VAL A  71
ILE A 149
LEU A 138
 None
 0.98A 4l1wB-2g0fA:
undetectable		 4l1wB-2g0fA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9d SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio cholerae) 		PF04952
(AstE_AspA) 		4 VAL A  44
VAL A  87
ILE A 245
LEU A  73
 None
 0.88A 4l1wB-2g9dA:
undetectable		 4l1wB-2g9dA:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 VAL A  54
VAL A 128
ILE A 129
TRP A 227
LEU A 308
 FFA  A 325 (-4.8A)
None
None
FFA  A 325 (-3.8A)
FFA  A 325 (-4.5A)
 0.42A 4l1wB-2ipjA:
56.2		 4l1wB-2ipjA:
98.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnv NIFU-LIKE PROTEIN 1,
CHLOROPLAST

(Oryza sativa) 		PF01106
(NifU) 		4 VAL A 108
VAL A 141
ILE A 138
LEU A  84
 None
 0.96A 4l1wB-2jnvA:
undetectable		 4l1wB-2jnvA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		4 VAL A 107
VAL A  83
ILE A  82
LEU A  26
 None
 0.90A 4l1wB-2owzA:
undetectable		 4l1wB-2owzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE

(Bacillus
anthracis) 		PF01467
(CTP_transf_like) 		4 VAL A 147
VAL A 129
ILE A 104
LEU A  20
 None
 0.93A 4l1wB-2qtnA:
undetectable		 4l1wB-2qtnA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 VAL A 375
VAL A 291
ILE A 292
LEU A 299
 None
 0.85A 4l1wB-2r6fA:
undetectable		 4l1wB-2r6fA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rir DIPICOLINATE
SYNTHASE, A CHAIN

(Bacillus
subtilis) 		PF01262
(AlaDh_PNT_C)
PF16924
(DpaA_N) 		5 TYR A 107
VAL A  74
VAL A  83
ILE A  50
LEU A  90
 None
 1.48A 4l1wB-2rirA:
undetectable		 4l1wB-2rirA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uun C-PHYCOCYANIN

(Leptolyngbya
sp.) 		PF00502
(Phycobilisome) 		4 VAL B  97
VAL B  41
ILE B  44
LEU B 139
 None
 0.97A 4l1wB-2uunB:
undetectable		 4l1wB-2uunB:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 VAL A 212
VAL A 151
ILE A 232
LEU A 244
 None
 0.87A 4l1wB-2yijA:
undetectable		 4l1wB-2yijA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9p CG5977-PA, ISOFORM A

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 VAL A 499
VAL A 623
ILE A 578
LEU A 532
 None
 0.92A 4l1wB-3b9pA:
undetectable		 4l1wB-3b9pA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		no annotation 4 VAL A 127
VAL A 235
ILE A  46
LEU A  75
 None
 0.92A 4l1wB-3cjiA:
undetectable		 4l1wB-3cjiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnq SUBTILISIN BPN'

(Bacillus
amyloliquefaciens) 		PF05922
(Inhibitor_I9) 		4 TYR P  67
VAL P  65
VAL P  29
ILE P  30
 None
 0.79A 4l1wB-3cnqP:
undetectable		 4l1wB-3cnqP:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cos ALCOHOL
DEHYDROGENASE 4

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A  85
VAL A  75
ILE A  39
LEU A  94
 None
 0.91A 4l1wB-3cosA:
undetectable		 4l1wB-3cosA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr7 ADENYLYL-SULFATE
KINASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase) 		4 VAL A 180
VAL A 134
ILE A  28
LEU A  41
 None
 0.94A 4l1wB-3cr7A:
undetectable		 4l1wB-3cr7A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 VAL A  63
VAL A 313
ILE A 312
LEU A  39
 None
 0.93A 4l1wB-3czeA:
7.4		 4l1wB-3czeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlj BETA-ALA-HIS
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 VAL A 364
VAL A 266
ILE A 264
LEU A 351
 None
 0.89A 4l1wB-3dljA:
undetectable		 4l1wB-3dljA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		4 VAL A  69
VAL A 126
ILE A 143
LEU A   4
 None
 0.97A 4l1wB-3f85A:
undetectable		 4l1wB-3f85A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		4 VAL A 220
VAL A 277
ILE A 294
LEU A 155
 None
 0.97A 4l1wB-3f85A:
undetectable		 4l1wB-3f85A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		4 VAL A 371
VAL A 428
ILE A 445
LEU A 306
 None
 0.98A 4l1wB-3f85A:
undetectable		 4l1wB-3f85A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8d BIOTIN CARBOXYLASE

(Escherichia
coli) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 VAL A  31
VAL A   6
ILE A  78
LEU A  85
 None
 0.95A 4l1wB-3g8dA:
undetectable		 4l1wB-3g8dA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		4 VAL A  90
VAL A 104
ILE A 105
LEU A 112
 None
 0.88A 4l1wB-3gs3A:
undetectable		 4l1wB-3gs3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A   9
VAL A  31
ILE A  30
LEU A 240
 None
 0.93A 4l1wB-3h3jA:
undetectable		 4l1wB-3h3jA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv1 POLAR AMINO ACID ABC
UPTAKE TRANSPORTER
SUBSTRATE BINDING
PROTEIN

(Streptococcus
thermophilus) 		PF00497
(SBP_bac_3) 		4 VAL A 224
VAL A 133
ILE A 204
LEU A 191
 None
 0.93A 4l1wB-3hv1A:
undetectable		 4l1wB-3hv1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 VAL A 393
VAL A 467
ILE A 465
LEU A 386
 None
 0.79A 4l1wB-3hwwA:
undetectable		 4l1wB-3hwwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijl MUCONATE
CYCLOISOMERASE

(Bacteroides
thetaiotaomicron) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 265
VAL A 273
ILE A 250
TRP A 229
 None
 0.96A 4l1wB-3ijlA:
6.5		 4l1wB-3ijlA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9c TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF13377
(Peripla_BP_3) 		4 VAL A 103
VAL A  76
ILE A 130
LEU A 311
 None
 0.93A 4l1wB-3k9cA:
undetectable		 4l1wB-3k9cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l76 ASPARTOKINASE

(Synechocystis
sp. PCC 6803) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		4 VAL A  40
VAL A  13
ILE A  19
LEU A  85
 None
 0.93A 4l1wB-3l76A:
undetectable		 4l1wB-3l76A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		4 VAL A 336
VAL A 312
ILE A 295
LEU A  60
 None
 0.99A 4l1wB-3ndaA:
undetectable		 4l1wB-3ndaA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE

(Mycolicibacterium
smegmatis) 		PF01182
(Glucosamine_iso) 		4 VAL A  54
VAL A  24
ILE A  27
LEU A  41
 None
 0.97A 4l1wB-3oc6A:
undetectable		 4l1wB-3oc6A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 VAL B 214
VAL B 186
ILE B 281
LEU B 493
 None
 0.94A 4l1wB-3opyB:
undetectable		 4l1wB-3opyB:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ory FLAP ENDONUCLEASE 1

(Desulfurococcus
amylolyticus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 VAL A 165
VAL A  29
ILE A  28
LEU A 213
 None
 0.79A 4l1wB-3oryA:
undetectable		 4l1wB-3oryA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p83 RIBONUCLEASE HII

(Archaeoglobus
fulgidus) 		PF01351
(RNase_HII) 		4 VAL D 194
VAL D  13
ILE D  14
TRP D 177
 None
 0.71A 4l1wB-3p83D:
undetectable		 4l1wB-3p83D:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru8 EPITOPE SCAFFOLD
2BODX43

(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct) 		PF01341
(Glyco_hydro_6) 		4 VAL X 106
VAL X  73
ILE X  90
LEU X  97
 None
 0.98A 4l1wB-3ru8X:
3.9		 4l1wB-3ru8X:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
marinum) 		PF03641
(Lysine_decarbox) 		4 VAL A 174
VAL A 139
ILE A 110
LEU A  29
 None
 0.98A 4l1wB-3sbxA:
undetectable		 4l1wB-3sbxA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3w ENOYL-COA HYDRATASE

(Mycolicibacterium
thermoresistibile) 		PF00378
(ECH_1) 		4 VAL A 188
VAL A 194
ILE A 139
LEU A 130
 None
 0.98A 4l1wB-3t3wA:
1.8		 4l1wB-3t3wA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdq PILY2 PROTEIN

(Pseudomonas
aeruginosa) 		PF14481
(Fimbrial_PilY2) 		4 VAL A  30
VAL A  70
ILE A  86
LEU A  61
 None
None
GOL  A 119 (-4.7A)
None
 0.90A 4l1wB-3tdqA:
undetectable		 4l1wB-3tdqA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		4 TYR A  67
VAL A  65
VAL A  29
ILE A  30
 None
 0.83A 4l1wB-3whiA:
undetectable		 4l1wB-3whiA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		4 VAL A 126
VAL A 136
ILE A  36
LEU A  10
 None
 0.97A 4l1wB-4aigA:
undetectable		 4l1wB-4aigA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8w GDP-L-FUCOSE
SYNTHASE

(Homo sapiens) 		PF01370
(Epimerase) 		4 VAL A 110
VAL A 168
ILE A 240
TRP A 229
 None
 0.94A 4l1wB-4b8wA:
undetectable		 4l1wB-4b8wA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus) 		PF00793
(DAHP_synth_1) 		4 VAL A 226
VAL A 209
ILE A 210
LEU A 252
 None
 0.92A 4l1wB-4c1lA:
11.3		 4l1wB-4c1lA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvg RHO-LIKE SMALL
GTPASE

(Entamoeba
histolytica) 		PF00071
(Ras) 		4 VAL A 128
VAL A  94
ILE A  23
LEU A  36
 None
 0.89A 4l1wB-4dvgA:
undetectable		 4l1wB-4dvgA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grs PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE,
2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus;
Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		4 VAL A 297
VAL A 280
ILE A 281
LEU A 323
 None
 0.86A 4l1wB-4grsA:
6.1		 4l1wB-4grsA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi5 MATRIX PROTEIN

(Borna disease
virus) 		PF16520
(BDV_M) 		4 VAL A  92
VAL A  16
ILE A  15
LEU A  22
 None
 0.99A 4l1wB-4hi5A:
undetectable		 4l1wB-4hi5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hji CS1 FIMBRIAL SUBUNIT
A

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		4 VAL A  82
VAL A 140
ILE A 157
LEU A  17
 None
 0.93A 4l1wB-4hjiA:
undetectable		 4l1wB-4hjiA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 VAL A 243
VAL A 156
ILE A 172
LEU A 233
 None
 0.94A 4l1wB-4hucA:
undetectable		 4l1wB-4hucA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huj UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored) 		4 VAL A  88
VAL A 160
ILE A 164
LEU A 134
 None
 0.98A 4l1wB-4hujA:
undetectable		 4l1wB-4hujA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 VAL A  31
VAL A   6
ILE A  78
LEU A  85
 None
 0.95A 4l1wB-4mv3A:
undetectable		 4l1wB-4mv3A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf1 ACETYLGLUTAMATE
KINASE

(Xylella
fastidiosa) 		PF04768
(NAT) 		4 VAL A 371
VAL A 293
ILE A 294
LEU A 307
 None
 0.95A 4l1wB-4nf1A:
undetectable		 4l1wB-4nf1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 TYR A 155
VAL A 124
ILE A 114
LEU A  14
 None
 0.91A 4l1wB-4pd3A:
undetectable		 4l1wB-4pd3A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01964
(ThiC_Rad_SAM) 		4 TYR A 318
VAL A 316
ILE A 272
LEU A 259
 None
None
None
SAH  A 703 ( 3.8A)
 0.93A 4l1wB-4s28A:
7.1		 4l1wB-4s28A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uc7 NUCLEOPROTEIN

(Human
orthopneumovirus) 		PF03246
(Pneumo_ncap) 		4 VAL A  95
VAL A  40
ILE A  44
LEU A  64
 None
 0.90A 4l1wB-4uc7A:
undetectable		 4l1wB-4uc7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v36 LYSYL-TRNA-DEPENDENT
L-YSYL-PHOSPHATIDYLG
YCEROL SYNTHASE

(Bacillus
licheniformis) 		PF09924
(DUF2156) 		4 TYR A 828
VAL A 796
ILE A 797
LEU A 630
 None
 0.87A 4l1wB-4v36A:
undetectable		 4l1wB-4v36A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH1

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N) 		4 VAL A 130
VAL A  11
ILE A  14
LEU A  87
 None
 1.00A 4l1wB-4w78A:
undetectable		 4l1wB-4w78A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yze HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR NEMR

(Escherichia
coli) 		PF00440
(TetR_N)
PF16925
(TetR_C_13) 		4 TYR A  90
VAL A 133
ILE A 134
LEU A 141
 None
 0.97A 4l1wB-4yzeA:
undetectable		 4l1wB-4yzeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Streptococcus
pneumoniae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 VAL A   9
VAL A 293
ILE A 298
LEU A 308
 None
 0.69A 4l1wB-5bqsA:
undetectable		 4l1wB-5bqsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czf PLASMID
STABILIZATION
PROTEIN PARE

(Escherichia
coli) 		PF05016
(ParE_toxin) 		4 VAL C  40
VAL C   4
TRP C  33
LEU C  14
 None
 0.98A 4l1wB-5czfC:
undetectable		 4l1wB-5czfC:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqx DESMOGLEIN-3

(Homo sapiens) 		PF00028
(Cadherin) 		4 VAL A 294
VAL A 325
ILE A 227
LEU A 280
 None
 0.97A 4l1wB-5eqxA:
undetectable		 4l1wB-5eqxA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fey E3 UBIQUITIN-PROTEIN
LIGASE TRIM32

(Homo sapiens) 		PF13445
(zf-RING_UBOX) 		4 VAL A  17
VAL A  82
ILE A  85
LEU A   9
 None
 0.89A 4l1wB-5feyA:
undetectable		 4l1wB-5feyA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhh ATP-DEPENDENT DNA
HELICASE PIF1

(Homo sapiens) 		PF02689
(Herpes_Helicase)
PF05970
(PIF1) 		4 VAL A 251
ILE A 336
TRP A 297
LEU A 319
 None
 1.00A 4l1wB-5fhhA:
undetectable		 4l1wB-5fhhA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		4 VAL A 700
VAL A 671
ILE A 664
LEU A 324
 None
 0.97A 4l1wB-5gslA:
10.1		 4l1wB-5gslA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE

([Eubacterium]
rectale) 		PF00078
(RVT_1) 		4 TYR A 102
VAL A 167
ILE A 168
LEU A 154
 None
 0.79A 4l1wB-5hhlA:
undetectable		 4l1wB-5hhlA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		4 TYR A  39
VAL A  29
ILE A  57
LEU A  87
 None
 0.87A 4l1wB-5hmqA:
7.1		 4l1wB-5hmqA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j72 PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE
AMIDASE,AUTOLYSIN
CWP6

(Clostridioides
difficile) 		PF01520
(Amidase_3)
PF04122
(CW_binding_2) 		4 VAL A 408
VAL A 435
ILE A 436
LEU A 443
 None
 0.75A 4l1wB-5j72A:
undetectable		 4l1wB-5j72A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE

(Bradyrhizobium
sp.) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 VAL A 210
ILE A 300
TRP A 253
LEU A 250
 None
 0.87A 4l1wB-5k8oA:
undetectable		 4l1wB-5k8oA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrv CARBOXYPEPTIDASE O

(Homo sapiens) 		no annotation 4 VAL A 126
VAL A 102
ILE A 105
LEU A 321
 None
 0.88A 4l1wB-5mrvA:
undetectable		 4l1wB-5mrvA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 TYR A 730
VAL A 738
ILE A 743
LEU A 822
 None
 0.95A 4l1wB-5o1pA:
undetectable		 4l1wB-5o1pA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2

(Homo sapiens) 		PF04056
(Ssl1) 		4 VAL E 167
VAL E  64
ILE E 107
LEU E 120
 None
 1.00A 4l1wB-5of4E:
undetectable		 4l1wB-5of4E:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 VAL A 152
VAL A 118
ILE A 119
LEU A 126
 None
 0.99A 4l1wB-5u94A:
undetectable		 4l1wB-5u94A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM

(Brucella
abortus) 		PF04069
(OpuAC) 		4 VAL A  26
VAL A 252
ILE A 248
LEU A 263
 None
 0.99A 4l1wB-5uveA:
undetectable		 4l1wB-5uveA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypt STILBENECARBOXYLATE
SYNTHASE 1

(Marchantia
polymorpha) 		no annotation 4 VAL A 130
VAL A 188
ILE A 226
LEU A 345
 None
 0.96A 4l1wB-5yptA:
undetectable		 4l1wB-5yptA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bii GLYOXYLATE REDUCTASE

(Pyrococcus
yayanosii) 		no annotation 4 VAL A 212
VAL A 244
ILE A 222
LEU A 201
 NAP  A 401 (-4.0A)
None
None
None
 0.94A 4l1wB-6biiA:
undetectable		 4l1wB-6biiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Lactobacillus
paracasei) 		no annotation 4 VAL A  92
VAL A  64
ILE A 120
LEU A 308
 None
 0.86A 4l1wB-6chkA:
undetectable		 4l1wB-6chkA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 152
VAL A 137
ILE A 142
LEU A 186
 None
 0.93A 4l1wB-6fc3A:
undetectable		 4l1wB-6fc3A:
14.01