SIMILAR PATTERNS OF AMINO ACIDS FOR 4L1W_A_STRA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens) 		PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 VAL A 268
ILE A 269
LEU A 434
LEU A 413
 None
 0.90A 4l1wA-1jeqA:
undetectable		 4l1wA-1jeqA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm1 RIESKE IRON-SULFUR
PROTEIN SOXF

(Sulfolobus
acidocaldarius) 		PF00355
(Rieske) 		4 VAL A 197
ILE A 196
LEU A  98
LEU A  95
 None
 1.00A 4l1wA-1jm1A:
undetectable		 4l1wA-1jm1A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 VAL A 108
ILE A 111
LEU A   3
LEU A  91
 None
 0.93A 4l1wA-1oi7A:
1.2		 4l1wA-1oi7A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tua HYPOTHETICAL PROTEIN
APE0754

(Aeropyrum
pernix) 		PF00013
(KH_1) 		4 VAL A  24
ILE A  28
LEU A  88
LEU A  81
 None
 0.88A 4l1wA-1tuaA:
undetectable		 4l1wA-1tuaA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlu GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomyces
cerevisiae) 		PF00171
(Aldedh) 		4 VAL A 128
ILE A 132
LEU A 192
LEU A 119
 None
 0.97A 4l1wA-1vluA:
undetectable		 4l1wA-1vluA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		4 VAL B 196
ILE B 195
LEU B  15
LEU B  19
 None
 0.74A 4l1wA-1wdwB:
1.1		 4l1wA-1wdwB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ww6 GALECTIN

(Agrocybe
cylindracea) 		PF00337
(Gal-bind_lectin) 		4 VAL A 152
ILE A  11
LEU A  61
LEU A  52
 None
 1.00A 4l1wA-1ww6A:
undetectable		 4l1wA-1ww6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0u ARSENICAL RESISTANCE
OPERON REPRESSOR,
PUTATIVE

(Archaeoglobus
fulgidus) 		PF12840
(HTH_20) 		4 VAL A  80
ILE A  71
LEU A  53
LEU A  58
 None
 0.77A 4l1wA-1y0uA:
undetectable		 4l1wA-1y0uA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		4 VAL A  80
ILE A 142
LEU A 169
LEU A 162
 None
 0.84A 4l1wA-1zg4A:
undetectable		 4l1wA-1zg4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B

(Methanocaldococcus
jannaschii) 		PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		4 VAL A 258
ILE A 261
LEU A 245
LEU A 286
 None
 0.84A 4l1wA-2apoA:
undetectable		 4l1wA-2apoA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc1 BETA-LACTAMASE

(Mycolicibacterium
fortuitum) 		PF13354
(Beta-lactamase2) 		4 VAL A  80
ILE A 142
LEU A 169
LEU A 162
 None
 1.04A 4l1wA-2cc1A:
undetectable		 4l1wA-2cc1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF08936
(CsoSCA) 		4 VAL A 304
ILE A 302
LEU A  53
LEU A 376
 None
 0.99A 4l1wA-2fgyA:
undetectable		 4l1wA-2fgyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF08442
(ATP-grasp_2) 		4 VAL A 243
ILE A 213
LEU B 275
LEU A 165
 None
 0.86A 4l1wA-2fpgA:
undetectable		 4l1wA-2fpgA:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		6 VAL A 128
ILE A 129
HIS A 222
TRP A 227
LEU A 306
LEU A 308
 None
None
NAP  A   1 ( 4.8A)
FFA  A 325 (-3.8A)
FFA  A 325 (-4.8A)
FFA  A 325 (-4.5A)
 0.72A 4l1wA-2ipjA:
56.1		 4l1wA-2ipjA:
98.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhe TRANSCRIPTION
REGULATOR TYRR

(Escherichia
coli) 		PF13188
(PAS_8) 		4 VAL A  64
ILE A  61
LEU A  28
LEU A  21
 None
 0.96A 4l1wA-2jheA:
undetectable		 4l1wA-2jheA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knd PHOTOSYSTEM II 11
KDA PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13326
(PSII_Pbs27) 		4 VAL A  18
ILE A  19
LEU A  91
LEU A  95
 None
 0.82A 4l1wA-2kndA:
undetectable		 4l1wA-2kndA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pe4 HYALURONIDASE-1

(Homo sapiens) 		PF01630
(Glyco_hydro_56) 		4 VAL A 127
ILE A 128
LEU A 232
LEU A 235
 None
 1.05A 4l1wA-2pe4A:
7.5		 4l1wA-2pe4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		4 VAL A 121
ILE A 122
LEU A 204
LEU A 174
 None
 1.00A 4l1wA-2ppvA:
3.5		 4l1wA-2ppvA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		4 VAL A 229
ILE A 233
LEU A 314
LEU A 212
 None
 0.97A 4l1wA-2ppvA:
3.5		 4l1wA-2ppvA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 4 VAL A 130
ILE A 129
LEU A  94
LEU A 116
 None
 0.78A 4l1wA-2q9uA:
undetectable		 4l1wA-2q9uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL

(Trichormus
variabilis) 		PF01261
(AP_endonuc_2) 		4 TYR A 109
ILE A 131
LEU A 168
LEU A 165
 None
 1.03A 4l1wA-2qw5A:
9.1		 4l1wA-2qw5A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		4 VAL A 396
ILE A 397
LEU A 287
LEU A 291
 None
 1.04A 4l1wA-2rjqA:
undetectable		 4l1wA-2rjqA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmo DEDICATOR OF
CYTOKINESIS PROTEIN
9

(Homo sapiens) 		PF06920
(DHR-2) 		4 VAL A  60
ILE A  61
LEU A  87
LEU A  91
 None
 1.04A 4l1wA-2wmoA:
undetectable		 4l1wA-2wmoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 VAL A 112
ILE A 116
LEU A 319
LEU A  24
 None
 1.00A 4l1wA-2x3nA:
undetectable		 4l1wA-2x3nA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgk ANTI-TUMOR LECTIN

(Agrocybe
aegerita) 		PF00337
(Gal-bind_lectin) 		4 VAL A 149
ILE A   8
LEU A  58
LEU A  49
 None
 1.00A 4l1wA-2zgkA:
undetectable		 4l1wA-2zgkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		4 VAL A 124
ILE A 125
LEU A  60
LEU A  68
 None
 1.04A 4l1wA-3a9gA:
undetectable		 4l1wA-3a9gA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8b CYSQ, SULFITE
SYNTHESIS PATHWAY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00459
(Inositol_P) 		4 TYR A 122
VAL A 168
ILE A 195
LEU A 158
 None
 0.80A 4l1wA-3b8bA:
undetectable		 4l1wA-3b8bA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3k ALANINE RACEMASE

(Actinobacillus
succinogenes) 		PF13377
(Peripla_BP_3) 		4 VAL A  27
ILE A  30
LEU A  59
LEU A  12
 None
 1.05A 4l1wA-3c3kA:
undetectable		 4l1wA-3c3kA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		4 VAL A 115
ILE A 105
LEU A  93
LEU A  96
 None
 0.92A 4l1wA-3dkaA:
undetectable		 4l1wA-3dkaA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9s PUTATIVE POLYKETIDE
CYCLASE

(Acidithiobacillus
ferrooxidans) 		PF07366
(SnoaL) 		4 TYR A  35
ILE A  24
HIS A 125
LEU A  62
 None
None
GOL  A 146 (-4.1A)
None
 1.02A 4l1wA-3f9sA:
undetectable		 4l1wA-3f9sA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmp ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD) 		4 VAL B 181
ILE B 182
LEU B  99
LEU B 103
 None
 1.03A 4l1wA-3fmpB:
undetectable		 4l1wA-3fmpB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		4 VAL A 135
ILE A 136
LEU A 157
LEU A 161
 None
 0.88A 4l1wA-3h74A:
undetectable		 4l1wA-3h74A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1

(Arabidopsis
thaliana) 		PF00282
(Pyridoxal_deC) 		4 VAL A 367
ILE A 366
LEU A 433
LEU A 354
 None
 0.80A 4l1wA-3hbxA:
undetectable		 4l1wA-3hbxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		4 ILE A 128
HIS A 250
LEU A 259
LEU A 260
 None
 0.89A 4l1wA-3hc1A:
undetectable		 4l1wA-3hc1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9f PUTATIVE TYPE 11
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF08241
(Methyltransf_11) 		4 VAL A 108
ILE A 109
LEU A 169
LEU A 171
 None
 0.78A 4l1wA-3i9fA:
undetectable		 4l1wA-3i9fA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi) 		PF00857
(Isochorismatase) 		4 VAL A 240
ILE A 241
LEU A 135
LEU A  84
 None
 1.00A 4l1wA-3irvA:
undetectable		 4l1wA-3irvA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k17 LIN0012 PROTEIN

(Listeria
innocua) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 TYR A  18
VAL A 232
ILE A 235
LEU A 283
 None
 0.99A 4l1wA-3k17A:
undetectable		 4l1wA-3k17A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6y CATENIN DELTA-1

(Homo sapiens) 		PF00514
(Arm) 		4 VAL A 562
ILE A 561
LEU A 548
LEU A 554
 None
 0.88A 4l1wA-3l6yA:
undetectable		 4l1wA-3l6yA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 VAL B 215
ILE B 218
LEU B 287
LEU B 295
 None
 1.04A 4l1wA-3o8oB:
undetectable		 4l1wA-3o8oB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovg AMIDOHYDROLASE

(Mycoplasma
synoviae) 		PF02126
(PTE) 		4 VAL A  65
ILE A  64
LEU A 301
LEU A 296
 None
 0.80A 4l1wA-3ovgA:
8.3		 4l1wA-3ovgA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN

(Salmonella
enterica) 		PF00291
(PALP) 		4 VAL B 201
ILE B 200
LEU B  21
LEU B  25
 None
 0.61A 4l1wA-3pr2B:
undetectable		 4l1wA-3pr2B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw9 UPF0603 PROTEIN
AT1G54780,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04536
(TPM_phosphatase) 		4 VAL A 189
ILE A 226
LEU A 115
LEU A 119
 None
 0.83A 4l1wA-3pw9A:
undetectable		 4l1wA-3pw9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyc E3 UBIQUITIN-PROTEIN
LIGASE SMURF1

(Homo sapiens) 		PF00168
(C2) 		4 VAL A  41
ILE A  40
LEU A 108
LEU A 137
 None
 0.83A 4l1wA-3pycA:
undetectable		 4l1wA-3pycA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		4 VAL A 199
ILE A 203
LEU A  62
LEU A 185
 None
 1.00A 4l1wA-3tosA:
1.9		 4l1wA-3tosA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B

(Drosophila
melanogaster) 		PF01399
(PCI) 		4 VAL A 317
ILE A 318
LEU A 190
LEU A 217
 None
 0.90A 4l1wA-3txmA:
undetectable		 4l1wA-3txmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		4 VAL A  56
ILE A  57
LEU A  86
LEU A  83
 None
 1.04A 4l1wA-3u4cA:
undetectable		 4l1wA-3u4cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 VAL B 334
ILE B 335
LEU B 545
LEU B 362
 None
 1.02A 4l1wA-3u9rB:
undetectable		 4l1wA-3u9rB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		4 VAL A  97
ILE A  98
LEU A 154
LEU A 115
 None
 0.85A 4l1wA-3vywA:
undetectable		 4l1wA-3vywA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waz PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
abyssi) 		PF09522
(RE_R_Pab1) 		4 VAL A 150
ILE A 149
LEU A 196
LEU A 200
 None
 0.98A 4l1wA-3wazA:
undetectable		 4l1wA-3wazA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg1 GALACTOSIDE-BINDING
LECTIN

(Agrocybe
aegerita) 		PF00337
(Gal-bind_lectin) 		4 VAL A 152
ILE A  11
LEU A  61
LEU A  52
 None
 1.04A 4l1wA-3wg1A:
undetectable		 4l1wA-3wg1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdj ENCA BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 VAL A  80
ILE A 142
LEU A 169
LEU A 162
 None
 0.88A 4l1wA-3zdjA:
undetectable		 4l1wA-3zdjA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjc GTPASE IMAP FAMILY
MEMBER 7

(Homo sapiens) 		PF04548
(AIG1) 		4 VAL A 157
ILE A 129
LEU A 137
LEU A 101
 None
 1.01A 4l1wA-3zjcA:
undetectable		 4l1wA-3zjcA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 VAL A 497
HIS A 481
LEU A 514
LEU A 518
 None
 0.99A 4l1wA-3zz1A:
4.2		 4l1wA-3zz1A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c75 BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 VAL A  80
ILE A 142
LEU A 169
LEU A 162
 None
 1.00A 4l1wA-4c75A:
undetectable		 4l1wA-4c75A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica) 		PF00069
(Pkinase)
PF09632
(Rac1) 		4 TYR B 181
VAL B 284
ILE B 285
LEU B 209
 None
 1.01A 4l1wA-4ci6B:
undetectable		 4l1wA-4ci6B:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 VAL A 442
ILE A 445
LEU A 228
LEU A  35
 None
 0.91A 4l1wA-4dshA:
undetectable		 4l1wA-4dshA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 VAL A 436
ILE A 498
LEU A 525
LEU A 518
 None
 0.81A 4l1wA-4dxbA:
undetectable		 4l1wA-4dxbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e14 KYNURENINE
FORMAMIDASE

(Drosophila
melanogaster) 		PF07859
(Abhydrolase_3) 		4 VAL A 172
ILE A 173
LEU A  81
LEU A 151
 None
EDO  A 402 (-4.1A)
None
None
 0.89A 4l1wA-4e14A:
undetectable		 4l1wA-4e14A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eca L-ASPARAGINE
AMIDOHYDROLASE

(Escherichia
coli) 		PF00710
(Asparaginase) 		4 VAL A 217
ILE A 216
LEU A 310
LEU A 306
 None
 1.03A 4l1wA-4ecaA:
undetectable		 4l1wA-4ecaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 TYR A 454
ILE A 814
LEU A 513
LEU A 509
 None
 0.84A 4l1wA-4gl2A:
undetectable		 4l1wA-4gl2A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J

(Bacillus
subtilis) 		PF13424
(TPR_12) 		4 TYR A  18
ILE A  86
LEU A  96
LEU A  97
 None
 0.94A 4l1wA-4gyoA:
undetectable		 4l1wA-4gyoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i16 CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11

(Mus musculus) 		PF00619
(CARD) 		4 VAL A  51
ILE A  52
LEU A  33
LEU A  77
 None
 0.89A 4l1wA-4i16A:
undetectable		 4l1wA-4i16A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 VAL A 565
HIS A 549
LEU A 582
LEU A 586
 None
 1.03A 4l1wA-4iigA:
3.0		 4l1wA-4iigA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'

(Hevea
brasiliensis) 		PF00332
(Glyco_hydro_17) 		4 VAL A  19
ILE A  20
LEU A  53
LEU A  51
 None
 0.64A 4l1wA-4iisA:
10.8		 4l1wA-4iisA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikb SORTING NEXIN-11

(Homo sapiens) 		PF00787
(PX) 		4 VAL B 132
ILE B 135
LEU B 116
LEU B 122
 None
 0.94A 4l1wA-4ikbB:
undetectable		 4l1wA-4ikbB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		4 TYR A 507
VAL A  62
LEU A 548
LEU A 542
 None
 0.88A 4l1wA-4iv9A:
undetectable		 4l1wA-4iv9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 VAL A  17
ILE A  16
LEU A 180
LEU A 152
 None
 1.03A 4l1wA-4j0eA:
undetectable		 4l1wA-4j0eA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwo PHOSPHATE BINDING
PROTEIN

(Planctopirus
limnophila) 		PF12727
(PBP_like) 		4 VAL A  68
ILE A  71
LEU A 333
LEU A 305
 None
 0.99A 4l1wA-4jwoA:
undetectable		 4l1wA-4jwoA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntl LIPOPROTEIN, YAEC
FAMILY

(Enterococcus
faecalis) 		PF03180
(Lipoprotein_9) 		4 TYR A 228
ILE A 135
HIS A  88
LEU A 184
 None
None
EDO  A 307 (-3.1A)
None
 1.04A 4l1wA-4ntlA:
undetectable		 4l1wA-4ntlA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N

(Thermococcus
kodakarensis) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF01194
(RNA_pol_N) 		4 VAL N  59
ILE N  56
LEU D 129
LEU D 123
 None
 1.02A 4l1wA-4qiwN:
undetectable		 4l1wA-4qiwN:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIM

(Thermotoga
maritima) 		PF02154
(FliM) 		4 VAL A 109
HIS A  59
LEU A 196
LEU A 219
 None
 0.97A 4l1wA-4qrmA:
undetectable		 4l1wA-4qrmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 VAL A2355
ILE A2400
LEU A2374
LEU A2378
 None
 1.04A 4l1wA-4rh7A:
undetectable		 4l1wA-4rh7A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38

(Homo sapiens) 		no annotation 4 VAL A 352
ILE A 351
HIS A 343
LEU A 311
 None
 0.86A 4l1wA-4rxxA:
undetectable		 4l1wA-4rxxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr3 ALANINE RACEMASE,
BIOSYNTHETIC

(Escherichia
coli) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 TYR A 357
ILE A  71
LEU A  13
LEU A  49
 None
 1.02A 4l1wA-4wr3A:
undetectable		 4l1wA-4wr3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yly PEPTIDYL-TRNA
HYDROLASE

(Staphylococcus
aureus) 		PF01195
(Pept_tRNA_hydro) 		4 VAL A  72
ILE A  75
LEU A  30
LEU A  37
 None
 0.87A 4l1wA-4ylyA:
undetectable		 4l1wA-4ylyA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 VAL A  52
ILE A  51
LEU A  78
LEU A  75
 None
 0.82A 4l1wA-4zudA:
undetectable		 4l1wA-4zudA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn8 GTPASE DER

(Coxiella
burnetii) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 TYR A 324
VAL A 260
ILE A 178
LEU A 191
 None
 1.00A 4l1wA-5dn8A:
undetectable		 4l1wA-5dn8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnw SHKAI2IB

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		4 VAL A 224
ILE A 228
LEU A  70
LEU A 198
 FMT  A 303 ( 4.4A)
None
None
None
 1.00A 4l1wA-5dnwA:
undetectable		 4l1wA-5dnwA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Vibrio cholerae) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		4 VAL A  28
ILE A  29
LEU A  59
LEU A  41
 None
 0.88A 4l1wA-5dt9A:
undetectable		 4l1wA-5dt9A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e43 BETA-LACTAMASE

(Streptosporangium
roseum) 		PF13354
(Beta-lactamase2) 		4 VAL A  80
ILE A 143
LEU A 170
LEU A 163
 None
 0.98A 4l1wA-5e43A:
undetectable		 4l1wA-5e43A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ekp UNCHARACTERIZED
GLYCOSYLTRANSFERASE
SLL0501

(Synechocystis
sp. PCC 6803) 		no annotation 4 VAL C  90
ILE C  91
LEU C  21
LEU C  25
 None
 1.05A 4l1wA-5ekpC:
undetectable		 4l1wA-5ekpC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqj TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Saccharomyces
cerevisiae) 		PF04189
(Gcd10p) 		4 VAL A 268
ILE A 269
LEU A 372
LEU A 376
 None
 0.90A 4l1wA-5eqjA:
undetectable		 4l1wA-5eqjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17

(Sphingomonas
sp. PAMC 26605) 		PF00067
(p450) 		4 TYR A  48
VAL A   7
ILE A   8
LEU A  31
 None
 0.94A 4l1wA-5h1zA:
undetectable		 4l1wA-5h1zA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 VAL A 561
HIS A 545
LEU A 578
LEU A 582
 None
 0.94A 4l1wA-5ju6A:
undetectable		 4l1wA-5ju6A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy1 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		4 VAL A 164
ILE A 163
LEU A 108
LEU A 112
 None
 1.04A 4l1wA-5jy1A:
undetectable		 4l1wA-5jy1A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kan HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 VAL A 182
ILE A 252
LEU A  70
LEU A  71
 None
 0.87A 4l1wA-5kanA:
undetectable		 4l1wA-5kanA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkg ANCMT E72A

(synthetic
construct) 		PF04587
(ADP_PFK_GK) 		4 VAL A 333
ILE A 344
LEU A 397
LEU A 417
 None
 0.82A 4l1wA-5kkgA:
undetectable		 4l1wA-5kkgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis) 		PF00291
(PALP) 		4 VAL B 200
ILE B 199
LEU B  20
LEU B  24
 None
 0.56A 4l1wA-5kzmB:
undetectable		 4l1wA-5kzmB:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Bos taurus) 		PF00146
(NADHdh)
PF00346
(Complex1_49kDa) 		4 TYR H 127
VAL D 415
LEU D  47
LEU D  68
 None
 0.94A 4l1wA-5lc5H:
undetectable		 4l1wA-5lc5H:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n56 SUPEROXIDE DISMUTASE
[MN/FE] 1

(Staphylococcus
aureus) 		no annotation 4 VAL A  99
ILE A 102
TRP A 183
LEU A 160
 None
 0.98A 4l1wA-5n56A:
undetectable		 4l1wA-5n56A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE

(metagenome) 		no annotation 4 VAL A 243
ILE A 125
LEU A 234
LEU A 113
 None
None
EDO  A 410 ( 4.9A)
EDO  A 410 ( 4.3A)
 0.79A 4l1wA-5nfqA:
undetectable		 4l1wA-5nfqA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ILE A2254
HIS A2218
LEU A2335
LEU A2284
 None
 0.91A 4l1wA-5nugA:
undetectable		 4l1wA-5nugA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc9 -

(-) 		no annotation 4 VAL A 167
ILE A 166
TRP A  34
LEU A 151
 None
 0.98A 4l1wA-5oc9A:
undetectable		 4l1wA-5oc9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		4 VAL A1323
ILE A1324
LEU A1369
LEU A1373
 None
 1.01A 4l1wA-5u1sA:
undetectable		 4l1wA-5u1sA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x29 ENVELOPE SMALL
MEMBRANE PROTEIN

(Severe acute
respiratory
syndrome-related
coronavirus) 		no annotation 4 VAL A  47
ILE A  46
LEU A  37
LEU A  39
 None
 0.90A 4l1wA-5x29A:
undetectable		 4l1wA-5x29A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2b SULFOTRANSFERASE

(Mus musculus) 		no annotation 4 TYR D 155
ILE D  91
LEU D  27
LEU D  30
 None
 0.86A 4l1wA-5x2bD:
undetectable		 4l1wA-5x2bD:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6m MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 5

(Mus musculus) 		no annotation 4 VAL B 121
ILE B  68
LEU B  56
LEU B  52
 None
 0.93A 4l1wA-5x6mB:
undetectable		 4l1wA-5x6mB:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		4 VAL A 638
HIS A 468
LEU A 460
LEU A 451
 None
 0.93A 4l1wA-5y7oA:
undetectable		 4l1wA-5y7oA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC

(Acetobacterium
woodii) 		no annotation 4 VAL C 166
ILE C 184
LEU C  58
LEU C 110
 None
 1.03A 4l1wA-6fahC:
undetectable		 4l1wA-6fahC:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 4 VAL A 536
ILE A 537
LEU A 518
LEU A 543
 None
 0.75A 4l1wA-6g9oA:
undetectable		 4l1wA-6g9oA:
12.62