SIMILAR PATTERNS OF AMINO ACIDS FOR 4L1A_A_AB1A101_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c9l | CLATHRIN (Rattusnorvegicus) |
PF01394(Clathrin_propel)PF09268(Clathrin-link) | 4 | ARG A 297ASP A 249GLY A 222THR A 277 | None | 1.01A | 4l1aB-1c9lA:undetectable | 4l1aB-1c9lA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cb8 | PROTEIN(CHONDROITINASE AC) (Pedobacterheparinus) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 4 | ASN A 489ASP A 523GLY A 394THR A 388 | None | 1.04A | 4l1aB-1cb8A:0.0 | 4l1aB-1cb8A:8.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dbn | PROTEIN(LEUKOAGGLUTININ) (Maackiaamurensis) |
PF00139(Lectin_legB) | 4 | ASN A 165ASP A 83PRO A 42THR A 227 | None | 1.11A | 4l1aB-1dbnA:0.0 | 4l1aB-1dbnA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dkp | PHYTASE (Escherichiacoli) |
PF00328(His_Phos_2) | 4 | ASN A 251ASP A 304GLY A 331THR A 319 | NoneIHP A 550 (-3.2A)NoneNone | 1.04A | 4l1aB-1dkpA:undetectable | 4l1aB-1dkpA:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1efp | PROTEIN (ELECTRONTRANSFERFLAVOPROTEIN) (Paracoccusdenitrificans) |
PF00766(ETF_alpha)PF01012(ETF) | 4 | ARG A 68ASN A 97PRO A 72THR A 73 | None | 1.00A | 4l1aB-1efpA:undetectable | 4l1aB-1efpA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m2w | MANNITOLDEHYDROGENASE (Pseudomonasfluorescens) |
PF01232(Mannitol_dh)PF08125(Mannitol_dh_C) | 4 | ARG A 39GLY A 89PRO A 234THR A 233 | NoneNoneNoneNAD A5500 (-4.5A) | 1.09A | 4l1aB-1m2wA:0.0 | 4l1aB-1m2wA:12.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mk2 | MADH-INTERACTINGPROTEINSMAD 3 (Homo sapiens) |
PF03166(MH2)PF11409(SARA) | 4 | ASP A 407GLY A 401PRO B 701THR B 702 | None | 1.08A | 4l1aB-1mk2A:0.0 | 4l1aB-1mk2A:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mu2 | HIV-2 RT (Humanimmunodeficiencyvirus 2) |
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 4 | ASP A 402GLY B 363PRO B 391THR B 418 | None | 0.98A | 4l1aB-1mu2A:0.0 | 4l1aB-1mu2A:11.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pby | QUINOHEMOPROTEINAMINE DEHYDROGENASE40 KDA SUBUNITQUINOHEMOPROTEINAMINE DEHYDROGENASE60 KDA SUBUNIT (Paracoccusdenitrificans) |
PF09098(Dehyd-heme_bind)PF09099(Qn_am_d_aIII)PF09100(Qn_am_d_aIV)PF14930(Qn_am_d_aII)no annotation | 4 | ARG B 104ASN A 124GLY A 146PRO B 114 | None | 1.04A | 4l1aB-1pbyB:undetectable | 4l1aB-1pbyB:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qaf | PROTEIN (COPPERAMINE OXIDASE) (Escherichiacoli) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3)PF07833(Cu_amine_oxidN1) | 4 | ARG A 452ASP A 329PRO A 710THR A 479 | None | 1.07A | 4l1aB-1qafA:undetectable | 4l1aB-1qafA:9.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qd6 | PROTEIN (OUTERMEMBRANEPHOSPHOLIPASE(OMPLA)) (Escherichiacoli) |
PF02253(PLA1) | 4 | ASN C 156ASP C 184GLY C 146PRO C 116 | NoneNoneHDS C 270 (-3.1A)HDS C 270 ( 4.6A) | 0.81A | 4l1aB-1qd6C:undetectable | 4l1aB-1qd6C:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qge | PROTEIN(TRIACYLGLYCEROLHYDROLASE) (Burkholderiaglumae) |
PF00561(Abhydrolase_1)no annotation | 4 | ASP E 287GLY E 264PRO D 113THR D 112 | CA E 320 (-3.4A)NoneNoneNone | 1.10A | 4l1aB-1qgeE:undetectable | 4l1aB-1qgeE:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qon | ACETYLCHOLINESTERASE (Drosophilamelanogaster) |
PF00135(COesterase) | 4 | ARG A 70ASN A 88GLY A 61THR A 65 | NoneNoneBMA A 996 (-2.6A)None | 1.09A | 4l1aB-1qonA:undetectable | 4l1aB-1qonA:11.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ton | TONIN (Rattus rattus) |
PF00089(Trypsin) | 4 | ASN A 145GLY A 186PRO A 219THR A 218 | None | 1.02A | 4l1aB-1tonA:1.2 | 4l1aB-1tonA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ulq | PUTATIVE ACETYL-COAACETYLTRANSFERASE (Thermusthermophilus) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 4 | ASN A 346ASP A 342GLY A 317THR A 368 | None | 1.09A | 4l1aB-1ulqA:undetectable | 4l1aB-1ulqA:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xqs | HEAT SHOCK 70 KDAPROTEIN 1HSPBP1 PROTEIN (Homo sapiens) |
PF00012(HSP70)PF08609(Fes1) | 4 | ARG C 264ASN A 133ASP A 139GLY A 88 | None | 1.07A | 4l1aB-1xqsC:undetectable | 4l1aB-1xqsC:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yew | PARTICULATE METHANEMONOOXYGENASE, ASUBUNITPARTICULATE METHANEMONOOXYGENASE, BSUBUNIT (Methylococcuscapsulatus) |
PF02461(AMO)PF04744(Monooxygenase_B) | 4 | ASN A 143GLY A 34PRO B 194THR B 193 | None | 0.86A | 4l1aB-1yewA:undetectable | 4l1aB-1yewA:13.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ys2 | LIPASE (Burkholderiacepacia) |
PF00561(Abhydrolase_1) | 4 | ASP X 288GLY X 265PRO X 113THR X 112 | CA X 400 (-3.2A)NoneNoneNone | 1.10A | 4l1aB-1ys2X:undetectable | 4l1aB-1ys2X:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zq1 | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT E (Pyrococcusabyssi) |
PF02637(GatB_Yqey)PF02934(GatB_N)PF02938(GAD) | 4 | ASP C 229GLY C 18PRO C 157THR C 158 | None | 0.97A | 4l1aB-1zq1C:undetectable | 4l1aB-1zq1C:9.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bud | MALES-ABSENT ON THEFIRST PROTEIN (Drosophilamelanogaster) |
PF11717(Tudor-knot) | 4 | ASP A 367GLY A 363PRO A 409THR A 402 | None | 1.06A | 4l1aB-2budA:undetectable | 4l1aB-2budA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bxy | MALTOOLIGOSYLTREHALOSE TREHALOHYDROLASE (Deinococcusradiodurans) |
PF00128(Alpha-amylase)PF02922(CBM_48)PF11941(DUF3459) | 4 | ARG A 273GLY A 381PRO A 278THR A 277 | None | 0.83A | 4l1aB-2bxyA:undetectable | 4l1aB-2bxyA:9.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c0z | NOVW (Streptomycesniveus) |
PF00908(dTDP_sugar_isom) | 4 | ASP A 168GLY A 120PRO A 158THR A 159 | SO4 A1191 ( 4.3A)NoneNoneNone | 0.88A | 4l1aB-2c0zA:undetectable | 4l1aB-2c0zA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fex | CONSERVEDHYPOTHETICAL PROTEIN (Agrobacteriumfabrum) |
PF01965(DJ-1_PfpI) | 4 | ASP A 14GLY A 72PRO A 37THR A 36 | None | 1.08A | 4l1aB-2fexA:undetectable | 4l1aB-2fexA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fgq | OUTER MEMBRANE PORINPROTEIN 32 (Delftiaacidovorans) |
PF13609(Porin_4) | 4 | ARG X 119ASP X 202GLY X 234THR X 238 | None | 1.10A | 4l1aB-2fgqX:undetectable | 4l1aB-2fgqX:14.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hih | LIPASE 46 KDA FORM (Staphylococcushyicus) |
no annotation | 4 | ASP A 357GLY A 315PRO A 176THR A 175 | CA A 603 (-2.3A)NoneNoneNone | 1.10A | 4l1aB-2hihA:undetectable | 4l1aB-2hihA:11.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2im5 | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Porphyromonasgingivalis) |
PF04095(NAPRTase) | 4 | ASN A 196ASP A 177PRO A 122THR A 121 | None | 1.02A | 4l1aB-2im5A:undetectable | 4l1aB-2im5A:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inr | DNA TOPOISOMERASE 4SUBUNIT A (Staphylococcusaureus) |
PF00521(DNA_topoisoIV) | 4 | ASP A 178GLY A 167PRO A 215THR A 216 | None | 1.02A | 4l1aB-2inrA:undetectable | 4l1aB-2inrA:12.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n5z | RESUSCITATION-PROMOTING FACTOR RPFC (Mycobacteriumtuberculosis) |
PF06737(Transglycosylas) | 4 | ASP A 10GLY A 32PRO A 74THR A 75 | None | 0.89A | 4l1aB-2n5zA:undetectable | 4l1aB-2n5zA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nmp | CYSTATHIONINEGAMMA-LYASE (Homo sapiens) |
PF01053(Cys_Met_Meta_PP) | 4 | ASP A 111GLY A 368PRO A 351THR A 355 | None | 0.95A | 4l1aB-2nmpA:undetectable | 4l1aB-2nmpA:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2otb | GFP-LIKE FLUORESCENTCHROMOPROTEIN CFP484 (Clavularia sp.) |
PF01353(GFP) | 4 | ARG A 70ASN A 81GLY A 6PRO A 37 | PIA A 66 ( 4.1A)NoneNoneNone | 1.10A | 4l1aB-2otbA:undetectable | 4l1aB-2otbA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q09 | IMIDAZOLONEPROPIONASE (unidentified) |
PF01979(Amidohydro_1) | 4 | ASN A 11GLY A 33PRO A 14THR A 13 | None | 0.99A | 4l1aB-2q09A:undetectable | 4l1aB-2q09A:12.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q2e | TYPE 2 DNATOPOISOMERASE 6SUBUNIT B (Methanosarcinamazei) |
PF02518(HATPase_c)PF09239(Topo-VIb_trans) | 4 | ARG B 181ASP B 212GLY B 187PRO B 35 | None | 1.05A | 4l1aB-2q2eB:undetectable | 4l1aB-2q2eB:10.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ARG A 8ASP A 29GLY A 48PRO A 81 | AB1 A 501 ( 4.7A)AB1 A 501 ( 3.3A)AB1 A 501 (-4.2A)AB1 A 501 (-4.2A) | 0.69A | 4l1aB-2rkfA:18.1 | 4l1aB-2rkfA:80.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vo8 | EXO-ALPHA-SIALIDASE (Clostridiumperfringens) |
PF12135(Sialidase_penC) | 4 | ASN A 943ASP A1025GLY A 969THR A 940 | None | 1.01A | 4l1aB-2vo8A:undetectable | 4l1aB-2vo8A:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wc7 | ALPHA AMYLASE,CATALYTIC REGION (Nostocpunctiforme) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 4 | ASN A 317GLY A 243PRO A 265THR A 266 | None | 0.67A | 4l1aB-2wc7A:undetectable | 4l1aB-2wc7A:11.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsk | GLYCOGEN DEBRANCHINGENZYME (Escherichiacoli) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | ARG A 343ASN A 307ASP A 283GLY A 83THR A 305 | None | 1.40A | 4l1aB-2wskA:undetectable | 4l1aB-2wskA:9.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y38 | LAMININ SUBUNITALPHA-5 (Mus musculus) |
PF00053(Laminin_EGF)PF00055(Laminin_N) | 4 | ARG A 265ASP A 199GLY A 205PRO A 189 | NAG A2001 (-3.8A)NoneNoneNone | 1.10A | 4l1aB-2y38A:undetectable | 4l1aB-2y38A:13.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ych | COMPETENCE PROTEINPILM (Thermusthermophilus) |
PF11104(PilM_2) | 4 | ASN A 333ASP A 328GLY A 321PRO A 336 | None | 0.95A | 4l1aB-2ychA:undetectable | 4l1aB-2ychA:12.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3acz | METHIONINEGAMMA-LYASE (Entamoebahistolytica) |
PF01053(Cys_Met_Meta_PP) | 4 | ASP A 105GLY A 360PRO A 343THR A 347 | NoneNoneNoneSO4 A2001 (-4.0A) | 1.05A | 4l1aB-3aczA:undetectable | 4l1aB-3aczA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ble | CITRAMALATE SYNTHASEFROM LEPTOSPIRAINTERROGANS (Leptospirainterrogans) |
PF00682(HMGL-like) | 4 | ASN A 150ASP A 178GLY A 191PRO A 156 | None | 1.11A | 4l1aB-3bleA:undetectable | 4l1aB-3bleA:15.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dzv | 4-METHYL-5-(BETA-HYDROXYETHYL)THIAZOLEKINASE (Enterococcusfaecalis) |
PF02110(HK) | 4 | ASP A 202GLY A 120PRO A 115THR A 90 | None | 1.10A | 4l1aB-3dzvA:undetectable | 4l1aB-3dzvA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f7o | SERINE PROTEASE (Purpureocilliumlilacinum) |
PF00082(Peptidase_S8) | 4 | ASN A 200ASP A 203GLY A 184PRO A 269 | None CA A 286 (-3.1A)NoneNone | 1.07A | 4l1aB-3f7oA:undetectable | 4l1aB-3f7oA:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g8q | PREDICTEDRNA-BINDING PROTEIN,CONTAINS THUMPDOMAIN (Methanopyruskandleri) |
PF00383(dCMP_cyt_deam_1)PF02926(THUMP) | 4 | ARG A 22ASP A 109GLY A 88THR A 25 | None | 0.95A | 4l1aB-3g8qA:undetectable | 4l1aB-3g8qA:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gcw | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8) | 4 | ASP A 360GLY A 356PRO A 345THR A 339 | None | 1.10A | 4l1aB-3gcwA:undetectable | 4l1aB-3gcwA:11.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gip | N-ACYL-D-GLUTAMATEDEACYLASE (Bordetellabronchiseptica) |
PF07969(Amidohydro_3) | 4 | ASP A 52GLY A 14PRO A 433THR A 435 | None | 1.02A | 4l1aB-3gipA:undetectable | 4l1aB-3gipA:11.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hnu | CYANOVIRIN-N-LIKEPROTEIN (Neurosporacrassa;Tuber borchii) |
PF08881(CVNH) | 4 | ASN X 54ASP X 36GLY X 15THR X 58 | None | 1.06A | 4l1aB-3hnuX:undetectable | 4l1aB-3hnuX:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpf | MUCONATECYCLOISOMERASE (Oceanobacillusiheyensis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ASN A 336ASP A 360GLY A 331THR A 339 | None | 1.07A | 4l1aB-3hpfA:undetectable | 4l1aB-3hpfA:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k8z | NAD-SPECIFICGLUTAMATEDEHYDROGENASE (Bacillussubtilis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | ARG A 47GLY A 180PRO A 77THR A 78 | None | 1.00A | 4l1aB-3k8zA:undetectable | 4l1aB-3k8zA:12.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mi6 | ALPHA-GALACTOSIDASE (Lactobacillusbrevis) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 4 | ASN A 230ASP A 260GLY A 249THR A 563 | None | 1.00A | 4l1aB-3mi6A:undetectable | 4l1aB-3mi6A:9.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3naf | CALCIUM-ACTIVATEDPOTASSIUM CHANNELSUBUNITALPHA-1,CALCIUM-ACTIVATED POTASSIUMCHANNEL SUBUNITALPHA-1,CALCIUM-ACTIVATED POTASSIUMCHANNEL SUBUNITALPHA-1 (Homo sapiens) |
PF03493(BK_channel_a) | 4 | ASN A 380ASP A 410GLY A 333PRO A 383 | None | 1.09A | 4l1aB-3nafA:undetectable | 4l1aB-3nafA:9.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q9n | COA BINDING PROTEINCONSENSUS ANKYRINREPEAT (Escherichiacoli) |
PF12796(Ank_2)PF13380(CoA_binding_2)PF13637(Ank_4) | 4 | ASN A 127GLY C 79PRO A 84THR A 108 | None | 1.00A | 4l1aB-3q9nA:undetectable | 4l1aB-3q9nA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6j | HYDROLASE, HALOACIDDEHALOGENASE-LIKEFAMILY (Pseudomonassyringae groupgenomosp. 3) |
PF13419(HAD_2) | 4 | ASN A 225ASP A 120GLY A 294THR A 215 | None | 0.95A | 4l1aB-3s6jA:undetectable | 4l1aB-3s6jA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3shw | TIGHT JUNCTIONPROTEIN ZO-1 (Homo sapiens) |
PF00595(PDZ)PF00625(Guanylate_kin)PF07653(SH3_2) | 4 | ASP A 655GLY A 651PRO A 710THR A 709 | None | 1.08A | 4l1aB-3shwA:undetectable | 4l1aB-3shwA:12.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ARG A 8ASP A 29GLY A 48PRO A 81 | 017 A 201 ( 4.8A)017 A 201 (-3.3A)None017 A 201 (-4.1A) | 0.81A | 4l1aB-3ttpA:17.9 | 4l1aB-3ttpA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w15 | PEROXISOMALTARGETING SIGNAL 2RECEPTOR (Saccharomycescerevisiae) |
PF00400(WD40) | 4 | ARG A 146ASN A 214GLY A 220THR A 151 | None | 1.06A | 4l1aB-3w15A:undetectable | 4l1aB-3w15A:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a3s | 6-PHOSPHOFRUCTOKINASE (Bacillussubtilis) |
PF00365(PFK) | 4 | ARG A 171ASP A 134GLY A 285THR A 125 | None | 0.90A | 4l1aB-4a3sA:undetectable | 4l1aB-4a3sA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ars | HISTIDINE ACIDPHOSPHATASE (Hafnia alvei) |
PF00328(His_Phos_2) | 4 | ASN A 254ASP A 307GLY A 334THR A 322 | NoneNoneNoneGOL A1419 (-4.4A) | 0.92A | 4l1aB-4arsA:undetectable | 4l1aB-4arsA:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eqv | INVERTASE 2 (Saccharomycescerevisiae) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 4 | ASN A 315ASP A 471PRO A 216THR A 212 | None | 0.97A | 4l1aB-4eqvA:undetectable | 4l1aB-4eqvA:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ha4 | BETA-GALACTOSIDASE (Acidilobussaccharovorans) |
PF00232(Glyco_hydro_1) | 4 | ASN A 368ASP A 375PRO A 271THR A 270 | None | 0.97A | 4l1aB-4ha4A:undetectable | 4l1aB-4ha4A:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ip4 | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME-LIKE PROTEIN (Ruegeria sp.TM1040) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ARG A 221ASN A 248GLY A 352PRO A 30 | NoneGOL A 501 ( 3.8A)NoneGOL A 501 ( 4.8A) | 0.96A | 4l1aB-4ip4A:undetectable | 4l1aB-4ip4A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4is4 | GLUTAMINE SYNTHETASE (Medicagotruncatula) |
PF00120(Gln-synt_C)PF03951(Gln-synt_N) | 4 | ASN A 61GLY A 65PRO A 103THR A 104 | None | 1.07A | 4l1aB-4is4A:undetectable | 4l1aB-4is4A:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iyo | CYSTATHIONINEGAMMA-LYASE-LIKEPROTEIN, LYS201AMODIFIED (Xanthomonasoryzae) |
PF01053(Cys_Met_Meta_PP) | 4 | ASP B 109GLY B 367PRO B 350THR B 354 | NoneNoneNoneNAK B 402 (-3.6A) | 1.04A | 4l1aB-4iyoB:undetectable | 4l1aB-4iyoB:14.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j6f | PUTATIVE ALCOHOLDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | ARG A 310ASP A 90GLY A 137PRO A 146 | GOL A 500 (-4.6A)NoneNoneNone | 0.85A | 4l1aB-4j6fA:undetectable | 4l1aB-4j6fA:11.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4maa | PUTATIVEBRANCHED-CHAIN AMINOACID ABCTRANSPORTER,PERIPLASMIC AMINOACID-BINDING PROTEIN (Pseudomonasprotegens) |
PF13458(Peripla_BP_6) | 4 | ASP A 76GLY A 48PRO A 126THR A 125 | None | 1.04A | 4l1aB-4maaA:undetectable | 4l1aB-4maaA:15.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8ASP A 29GLY A 48PRO A 81THR A 82 | RIT A 500 (-3.2A)RIT A 500 (-3.2A)RIT A 500 (-4.8A)RIT A 500 (-3.9A)RIT A 500 (-3.5A) | 0.88A | 4l1aB-4njvA:17.7 | 4l1aB-4njvA:87.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ARG A 8GLY A 52PRO A 81THR A 82 | RIT A 500 (-3.2A)NoneRIT A 500 (-3.9A)RIT A 500 (-3.5A) | 0.91A | 4l1aB-4njvA:17.7 | 4l1aB-4njvA:87.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nwv | CAPSID PROTEIN (Orsay virus) |
PF11729(Capsid-VNN) | 4 | ASP A 312GLY A 243PRO A 330THR A 331 | None | 0.94A | 4l1aB-4nwvA:undetectable | 4l1aB-4nwvA:15.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nww | CAPSID PROTEIN (Orsay virus) |
PF11729(Capsid-VNN) | 4 | ASP A 312GLY A 243PRO A 330THR A 331 | None | 0.94A | 4l1aB-4nwwA:undetectable | 4l1aB-4nwwA:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p8b | TRAP-TYPETRANSPORTER,PERIPLASMICCOMPONENT (Cupriavidusnecator) |
PF03480(DctP) | 4 | ARG A 165ASP A 212GLY A 230THR A 235 | None | 1.08A | 4l1aB-4p8bA:undetectable | 4l1aB-4p8bA:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q16 | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Deinococcusradiodurans) |
PF02540(NAD_synthase) | 4 | ARG A 136ASN A 142ASP A 182GLY A 175 | None | 0.99A | 4l1aB-4q16A:undetectable | 4l1aB-4q16A:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qn0 | ENDONUCLEASE G,MITOCHONDRIAL (Caenorhabditiselegans) |
PF01223(Endonuclease_NS) | 4 | ARG A 117ASN A 154GLY A 206THR A 165 | None | 1.09A | 4l1aB-4qn0A:undetectable | 4l1aB-4qn0A:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3l | MAJOR PILIN PROTEIN (Streptococcuspneumoniae) |
no annotation | 4 | ASP A 120GLY A 321PRO A 277THR A 276 | None | 0.99A | 4l1aB-4s3lA:undetectable | 4l1aB-4s3lA:13.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tz5 | PUTATIVE SECRETEDPROTEIN (Streptomycessp. SirexAA-E) |
no annotation | 4 | ASN A 158ASP A 204GLY A 293THR A 131 | None | 1.08A | 4l1aB-4tz5A:undetectable | 4l1aB-4tz5A:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xfj | ARGININOSUCCINATESYNTHASE (Mycolicibacteriumthermoresistibile) |
PF00764(Arginosuc_synth) | 4 | ASP A 207GLY A 346PRO A 215THR A 214 | None | 1.03A | 4l1aB-4xfjA:undetectable | 4l1aB-4xfjA:13.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0n | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Streptobacillusmoniliformis) |
PF13407(Peripla_BP_4) | 4 | ASN A 68ASP A 209GLY A 173PRO A 95 | None | 1.02A | 4l1aB-4z0nA:undetectable | 4l1aB-4z0nA:14.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z3o | DNA TOPOISOMERASE 4SUBUNITB,PARE30-PARC55FUSED TOPO IV FROMS. PNEUMONIAE (Streptococcuspneumoniae) |
PF00521(DNA_topoisoIV)PF00986(DNA_gyraseB_C)PF01751(Toprim) | 4 | ASP A1177GLY A1166PRO A1214THR A1215 | None | 1.03A | 4l1aB-4z3oA:undetectable | 4l1aB-4z3oA:8.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgv | FERREDOXIN RECEPTOR (Pectobacteriumatrosepticum) |
PF07715(Plug) | 4 | ASN A 135ASP A 131GLY A 315THR A 365 | NoneNoneLDA A 901 (-3.9A)None | 0.99A | 4l1aB-4zgvA:undetectable | 4l1aB-4zgvA:8.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zkt | BONTOXILYSIN A (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 4 | ASN A1078GLY A 889PRO A 882THR A 883 | None | 1.11A | 4l1aB-4zktA:undetectable | 4l1aB-4zktA:5.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zys | EXOTOXIN 6 (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 4 | ASN A 97ASP A 156GLY A 118THR A 57 | None | 1.06A | 4l1aB-4zysA:undetectable | 4l1aB-4zysA:18.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ARG A 8ASN A 25ASP A 29GLY A 48 | None | 0.57A | 4l1aB-5b18A:16.8 | 4l1aB-5b18A:79.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ARG A 8ASN A 25ASP A 29PRO A 81 | None | 0.58A | 4l1aB-5b18A:16.8 | 4l1aB-5b18A:79.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b4w | PLEXIN-B1 (Homo sapiens) |
PF01403(Sema)PF01437(PSI) | 4 | ASP A 456GLY A 50PRO A 30THR A 29 | None | 0.95A | 4l1aB-5b4wA:undetectable | 4l1aB-5b4wA:11.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d1r | RV1816TRANSCRIPTIONALREGULATOR (Mycobacteriumtuberculosis) |
PF00440(TetR_N) | 4 | ARG A 100ASP A 144GLY A 149THR A 224 | None | 1.06A | 4l1aB-5d1rA:undetectable | 4l1aB-5d1rA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gve | DNA TOPOISOMERASE3-BETA-1 (Homo sapiens) |
PF01131(Topoisom_bac)PF01751(Toprim) | 4 | ASN A 520GLY A 189PRO A 220THR A 221 | None | 1.07A | 4l1aB-5gveA:undetectable | 4l1aB-5gveA:10.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h5j | FERREDOXIN--NADPREDUCTASE (Zea mays) |
PF00175(NAD_binding_1) | 4 | ASP A 60GLY A 110PRO A 153THR A 28 | None | 1.10A | 4l1aB-5h5jA:undetectable | 4l1aB-5h5jA:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h8y | SULFITE REDUCTASE[FERREDOXIN],CHLOROPLASTIC (Zea mays) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 4 | ARG A 124ASP A 141GLY A 430THR A 155 | CL A 704 (-3.6A)NoneNoneSRM A 702 (-3.2A) | 0.93A | 4l1aB-5h8yA:undetectable | 4l1aB-5h8yA:12.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hqb | ALPHA-GLUCOSIDASE (Pseudoalteromonassp. K8) |
PF10566(Glyco_hydro_97)PF14508(GH97_N)PF14509(GH97_C) | 4 | ASP A 263GLY A 90PRO A 468THR A 466 | None | 1.05A | 4l1aB-5hqbA:undetectable | 4l1aB-5hqbA:9.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kg9 | ANTIBODY RE505-22FAB LIGHT CHAIN (Homo sapiens;Mus musculus) |
no annotation | 4 | ASN L 171ASP L 82GLY L 15PRO L 110 | None | 0.92A | 4l1aB-5kg9L:undetectable | 4l1aB-5kg9L:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lgx | PENTAERYTHRITOLTETRANITRATEREDUCTASE (Enterobactercloacae) |
PF00724(Oxidored_FMN) | 4 | ASN A 128GLY A 185PRO A 148THR A 147 | None | 1.10A | 4l1aB-5lgxA:undetectable | 4l1aB-5lgxA:14.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m5p | PRE-MRNA-SPLICINGHELICASE BRR2 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 4 | ARG A1781ASP A1793GLY A1310PRO A1210 | None | 1.07A | 4l1aB-5m5pA:undetectable | 4l1aB-5m5pA:4.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n9x | ADENYLATION DOMAIN (Streptomycessp.) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | ARG A 510ASN A 513GLY A 312PRO A 258 | NoneNoneTHR A 601 ( 3.5A)None | 1.06A | 4l1aB-5n9xA:undetectable | 4l1aB-5n9xA:10.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o8f | NANOBODY NB25 (Lama glama) |
no annotation | 4 | ASN L 77ASP L 73GLY L 55PRO L 32 | None | 1.06A | 4l1aB-5o8fL:undetectable | 4l1aB-5o8fL:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u6s | UDP-GLYCOSYLTRANSFERASE 74F2 (Arabidopsisthaliana) |
PF00201(UDPGT) | 4 | ASP A 440GLY A 433PRO A 224THR A 225 | None | 1.10A | 4l1aB-5u6sA:undetectable | 4l1aB-5u6sA:12.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ujz | HEMAGGLUTININ HA1HEMAGGLUTININ HA2 (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | ASN A 15ASP A 18GLY A 320THR B 515 | NAG A 408 (-1.8A)NoneNoneNone | 0.98A | 4l1aB-5ujzA:undetectable | 4l1aB-5ujzA:15.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vlh | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8)PF05922(Inhibitor_I9) | 4 | ASP A 360GLY A 356PRO A 345THR A 339 | CA A 501 (-2.5A)NoneNoneNone | 1.11A | 4l1aB-5vlhA:undetectable | 4l1aB-5vlhA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vsj | ALPHA-1,4-GLUCAN:MALTOSE-1-PHOSPHATEMALTOSYLTRANSFERASE1 (Streptomycescoelicolor) |
PF00128(Alpha-amylase)PF11896(DUF3416) | 4 | ARG A 648ASN A 602GLY A 490THR A 654 | None | 0.97A | 4l1aB-5vsjA:undetectable | 4l1aB-5vsjA:9.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xmj | FUMARATE REDUCTASEFLAVOPROTEIN SUBUNITSUCCINATEDEHYDROGENASEIRON-SULFUR SUBUNIT (Desulfovibriogigas) |
no annotation | 4 | ARG B 178ASN A 162GLY A 13THR A 166 | NoneNoneFAD A 701 (-3.5A)None | 0.97A | 4l1aB-5xmjB:undetectable | 4l1aB-5xmjB:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cjb | CYSTATHIONINEBETA-LYASE (Legionellapneumophila) |
no annotation | 4 | ASP A 98GLY A 356PRO A 339THR A 343 | NoneNoneNoneFMT A 401 (-3.6A) | 1.05A | 4l1aB-6cjbA:undetectable | 4l1aB-6cjbA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d8w | HEMAGGLUTININ (Influenza Avirus) |
no annotation | 4 | ASN A 13ASP A 16GLY A 319THR A 344 | None | 0.95A | 4l1aB-6d8wA:undetectable | 4l1aB-6d8wA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6exv | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB2 (Sus scrofa) |
no annotation | 4 | ARG B 938GLY B1024PRO B1045THR B1046 | None | 0.95A | 4l1aB-6exvB:undetectable | 4l1aB-6exvB:20.56 |