SIMILAR PATTERNS OF AMINO ACIDS FOR 4L1A_A_AB1A101_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9l CLATHRIN

(Rattus
norvegicus)
PF01394
(Clathrin_propel)
PF09268
(Clathrin-link)
4 ARG A 297
ASP A 249
GLY A 222
THR A 277
None
1.01A 4l1aB-1c9lA:
undetectable
4l1aB-1c9lA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)


(Pedobacter
heparinus)
PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N)
4 ASN A 489
ASP A 523
GLY A 394
THR A 388
None
1.04A 4l1aB-1cb8A:
0.0
4l1aB-1cb8A:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbn PROTEIN
(LEUKOAGGLUTININ)


(Maackia
amurensis)
PF00139
(Lectin_legB)
4 ASN A 165
ASP A  83
PRO A  42
THR A 227
None
1.11A 4l1aB-1dbnA:
0.0
4l1aB-1dbnA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli)
PF00328
(His_Phos_2)
4 ASN A 251
ASP A 304
GLY A 331
THR A 319
None
IHP  A 550 (-3.2A)
None
None
1.04A 4l1aB-1dkpA:
undetectable
4l1aB-1dkpA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)


(Paracoccus
denitrificans)
PF00766
(ETF_alpha)
PF01012
(ETF)
4 ARG A  68
ASN A  97
PRO A  72
THR A  73
None
1.00A 4l1aB-1efpA:
undetectable
4l1aB-1efpA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE


(Pseudomonas
fluorescens)
PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C)
4 ARG A  39
GLY A  89
PRO A 234
THR A 233
None
None
None
NAD  A5500 (-4.5A)
1.09A 4l1aB-1m2wA:
0.0
4l1aB-1m2wA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk2 MADH-INTERACTING
PROTEIN
SMAD 3


(Homo sapiens)
PF03166
(MH2)
PF11409
(SARA)
4 ASP A 407
GLY A 401
PRO B 701
THR B 702
None
1.08A 4l1aB-1mk2A:
0.0
4l1aB-1mk2A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2)
PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb)
4 ASP A 402
GLY B 363
PRO B 391
THR B 418
None
0.98A 4l1aB-1mu2A:
0.0
4l1aB-1mu2A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT


(Paracoccus
denitrificans)
PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII)
no annotation
4 ARG B 104
ASN A 124
GLY A 146
PRO B 114
None
1.04A 4l1aB-1pbyB:
undetectable
4l1aB-1pbyB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)


(Escherichia
coli)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1)
4 ARG A 452
ASP A 329
PRO A 710
THR A 479
None
1.07A 4l1aB-1qafA:
undetectable
4l1aB-1qafA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd6 PROTEIN (OUTER
MEMBRANE
PHOSPHOLIPASE
(OMPLA))


(Escherichia
coli)
PF02253
(PLA1)
4 ASN C 156
ASP C 184
GLY C 146
PRO C 116
None
None
HDS  C 270 (-3.1A)
HDS  C 270 ( 4.6A)
0.81A 4l1aB-1qd6C:
undetectable
4l1aB-1qd6C:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)


(Burkholderia
glumae)
PF00561
(Abhydrolase_1)
no annotation
4 ASP E 287
GLY E 264
PRO D 113
THR D 112
CA  E 320 (-3.4A)
None
None
None
1.10A 4l1aB-1qgeE:
undetectable
4l1aB-1qgeE:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster)
PF00135
(COesterase)
4 ARG A  70
ASN A  88
GLY A  61
THR A  65
None
None
BMA  A 996 (-2.6A)
None
1.09A 4l1aB-1qonA:
undetectable
4l1aB-1qonA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ton TONIN

(Rattus rattus)
PF00089
(Trypsin)
4 ASN A 145
GLY A 186
PRO A 219
THR A 218
None
1.02A 4l1aB-1tonA:
1.2
4l1aB-1tonA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE


(Thermus
thermophilus)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
4 ASN A 346
ASP A 342
GLY A 317
THR A 368
None
1.09A 4l1aB-1ulqA:
undetectable
4l1aB-1ulqA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HEAT SHOCK 70 KDA
PROTEIN 1
HSPBP1 PROTEIN


(Homo sapiens)
PF00012
(HSP70)
PF08609
(Fes1)
4 ARG C 264
ASN A 133
ASP A 139
GLY A  88
None
1.07A 4l1aB-1xqsC:
undetectable
4l1aB-1xqsC:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT


(Methylococcus
capsulatus)
PF02461
(AMO)
PF04744
(Monooxygenase_B)
4 ASN A 143
GLY A  34
PRO B 194
THR B 193
None
0.86A 4l1aB-1yewA:
undetectable
4l1aB-1yewA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys2 LIPASE

(Burkholderia
cepacia)
PF00561
(Abhydrolase_1)
4 ASP X 288
GLY X 265
PRO X 113
THR X 112
CA  X 400 (-3.2A)
None
None
None
1.10A 4l1aB-1ys2X:
undetectable
4l1aB-1ys2X:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E


(Pyrococcus
abyssi)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD)
4 ASP C 229
GLY C  18
PRO C 157
THR C 158
None
0.97A 4l1aB-1zq1C:
undetectable
4l1aB-1zq1C:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bud MALES-ABSENT ON THE
FIRST PROTEIN


(Drosophila
melanogaster)
PF11717
(Tudor-knot)
4 ASP A 367
GLY A 363
PRO A 409
THR A 402
None
1.06A 4l1aB-2budA:
undetectable
4l1aB-2budA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE


(Deinococcus
radiodurans)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459)
4 ARG A 273
GLY A 381
PRO A 278
THR A 277
None
0.83A 4l1aB-2bxyA:
undetectable
4l1aB-2bxyA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0z NOVW

(Streptomyces
niveus)
PF00908
(dTDP_sugar_isom)
4 ASP A 168
GLY A 120
PRO A 158
THR A 159
SO4  A1191 ( 4.3A)
None
None
None
0.88A 4l1aB-2c0zA:
undetectable
4l1aB-2c0zA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fex CONSERVED
HYPOTHETICAL PROTEIN


(Agrobacterium
fabrum)
PF01965
(DJ-1_PfpI)
4 ASP A  14
GLY A  72
PRO A  37
THR A  36
None
1.08A 4l1aB-2fexA:
undetectable
4l1aB-2fexA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgq OUTER MEMBRANE PORIN
PROTEIN 32


(Delftia
acidovorans)
PF13609
(Porin_4)
4 ARG X 119
ASP X 202
GLY X 234
THR X 238
None
1.10A 4l1aB-2fgqX:
undetectable
4l1aB-2fgqX:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus)
no annotation 4 ASP A 357
GLY A 315
PRO A 176
THR A 175
CA  A 603 (-2.3A)
None
None
None
1.10A 4l1aB-2hihA:
undetectable
4l1aB-2hihA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Porphyromonas
gingivalis)
PF04095
(NAPRTase)
4 ASN A 196
ASP A 177
PRO A 122
THR A 121
None
1.02A 4l1aB-2im5A:
undetectable
4l1aB-2im5A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inr DNA TOPOISOMERASE 4
SUBUNIT A


(Staphylococcus
aureus)
PF00521
(DNA_topoisoIV)
4 ASP A 178
GLY A 167
PRO A 215
THR A 216
None
1.02A 4l1aB-2inrA:
undetectable
4l1aB-2inrA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n5z RESUSCITATION-PROMOT
ING FACTOR RPFC


(Mycobacterium
tuberculosis)
PF06737
(Transglycosylas)
4 ASP A  10
GLY A  32
PRO A  74
THR A  75
None
0.89A 4l1aB-2n5zA:
undetectable
4l1aB-2n5zA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE


(Homo sapiens)
PF01053
(Cys_Met_Meta_PP)
4 ASP A 111
GLY A 368
PRO A 351
THR A 355
None
0.95A 4l1aB-2nmpA:
undetectable
4l1aB-2nmpA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484


(Clavularia sp.)
PF01353
(GFP)
4 ARG A  70
ASN A  81
GLY A   6
PRO A  37
PIA  A  66 ( 4.1A)
None
None
None
1.10A 4l1aB-2otbA:
undetectable
4l1aB-2otbA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E


(unidentified)
PF01979
(Amidohydro_1)
4 ASN A  11
GLY A  33
PRO A  14
THR A  13
None
0.99A 4l1aB-2q09A:
undetectable
4l1aB-2q09A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B


(Methanosarcina
mazei)
PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans)
4 ARG B 181
ASP B 212
GLY B 187
PRO B  35
None
1.05A 4l1aB-2q2eB:
undetectable
4l1aB-2q2eB:
10.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 ARG A   8
ASP A  29
GLY A  48
PRO A  81
AB1  A 501 ( 4.7A)
AB1  A 501 ( 3.3A)
AB1  A 501 (-4.2A)
AB1  A 501 (-4.2A)
0.69A 4l1aB-2rkfA:
18.1
4l1aB-2rkfA:
80.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo8 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens)
PF12135
(Sialidase_penC)
4 ASN A 943
ASP A1025
GLY A 969
THR A 940
None
1.01A 4l1aB-2vo8A:
undetectable
4l1aB-2vo8A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc7 ALPHA AMYLASE,
CATALYTIC REGION


(Nostoc
punctiforme)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
4 ASN A 317
GLY A 243
PRO A 265
THR A 266
None
0.67A 4l1aB-2wc7A:
undetectable
4l1aB-2wc7A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME


(Escherichia
coli)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
5 ARG A 343
ASN A 307
ASP A 283
GLY A  83
THR A 305
None
1.40A 4l1aB-2wskA:
undetectable
4l1aB-2wskA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y38 LAMININ SUBUNIT
ALPHA-5


(Mus musculus)
PF00053
(Laminin_EGF)
PF00055
(Laminin_N)
4 ARG A 265
ASP A 199
GLY A 205
PRO A 189
NAG  A2001 (-3.8A)
None
None
None
1.10A 4l1aB-2y38A:
undetectable
4l1aB-2y38A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM


(Thermus
thermophilus)
PF11104
(PilM_2)
4 ASN A 333
ASP A 328
GLY A 321
PRO A 336
None
0.95A 4l1aB-2ychA:
undetectable
4l1aB-2ychA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE


(Entamoeba
histolytica)
PF01053
(Cys_Met_Meta_PP)
4 ASP A 105
GLY A 360
PRO A 343
THR A 347
None
None
None
SO4  A2001 (-4.0A)
1.05A 4l1aB-3aczA:
undetectable
4l1aB-3aczA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ble CITRAMALATE SYNTHASE
FROM LEPTOSPIRA
INTERROGANS


(Leptospira
interrogans)
PF00682
(HMGL-like)
4 ASN A 150
ASP A 178
GLY A 191
PRO A 156
None
1.11A 4l1aB-3bleA:
undetectable
4l1aB-3bleA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE


(Enterococcus
faecalis)
PF02110
(HK)
4 ASP A 202
GLY A 120
PRO A 115
THR A  90
None
1.10A 4l1aB-3dzvA:
undetectable
4l1aB-3dzvA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7o SERINE PROTEASE

(Purpureocillium
lilacinum)
PF00082
(Peptidase_S8)
4 ASN A 200
ASP A 203
GLY A 184
PRO A 269
None
CA  A 286 (-3.1A)
None
None
1.07A 4l1aB-3f7oA:
undetectable
4l1aB-3f7oA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN


(Methanopyrus
kandleri)
PF00383
(dCMP_cyt_deam_1)
PF02926
(THUMP)
4 ARG A  22
ASP A 109
GLY A  88
THR A  25
None
0.95A 4l1aB-3g8qA:
undetectable
4l1aB-3g8qA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
4 ASP A 360
GLY A 356
PRO A 345
THR A 339
None
1.10A 4l1aB-3gcwA:
undetectable
4l1aB-3gcwA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gip N-ACYL-D-GLUTAMATE
DEACYLASE


(Bordetella
bronchiseptica)
PF07969
(Amidohydro_3)
4 ASP A  52
GLY A  14
PRO A 433
THR A 435
None
1.02A 4l1aB-3gipA:
undetectable
4l1aB-3gipA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnu CYANOVIRIN-N-LIKE
PROTEIN


(Neurospora
crassa;
Tuber borchii)
PF08881
(CVNH)
4 ASN X  54
ASP X  36
GLY X  15
THR X  58
None
1.06A 4l1aB-3hnuX:
undetectable
4l1aB-3hnuX:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE


(Oceanobacillus
iheyensis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASN A 336
ASP A 360
GLY A 331
THR A 339
None
1.07A 4l1aB-3hpfA:
undetectable
4l1aB-3hpfA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE


(Bacillus
subtilis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ARG A  47
GLY A 180
PRO A  77
THR A  78
None
1.00A 4l1aB-3k8zA:
undetectable
4l1aB-3k8zA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
4 ASN A 230
ASP A 260
GLY A 249
THR A 563
None
1.00A 4l1aB-3mi6A:
undetectable
4l1aB-3mi6A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1


(Homo sapiens)
PF03493
(BK_channel_a)
4 ASN A 380
ASP A 410
GLY A 333
PRO A 383
None
1.09A 4l1aB-3nafA:
undetectable
4l1aB-3nafA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9n COA BINDING PROTEIN
CONSENSUS ANKYRIN
REPEAT


(Escherichia
coli)
PF12796
(Ank_2)
PF13380
(CoA_binding_2)
PF13637
(Ank_4)
4 ASN A 127
GLY C  79
PRO A  84
THR A 108
None
1.00A 4l1aB-3q9nA:
undetectable
4l1aB-3q9nA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY


(Pseudomonas
syringae group
genomosp. 3)
PF13419
(HAD_2)
4 ASN A 225
ASP A 120
GLY A 294
THR A 215
None
0.95A 4l1aB-3s6jA:
undetectable
4l1aB-3s6jA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shw TIGHT JUNCTION
PROTEIN ZO-1


(Homo sapiens)
PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2)
4 ASP A 655
GLY A 651
PRO A 710
THR A 709
None
1.08A 4l1aB-3shwA:
undetectable
4l1aB-3shwA:
12.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 ARG A   8
ASP A  29
GLY A  48
PRO A  81
017  A 201 ( 4.8A)
017  A 201 (-3.3A)
None
017  A 201 (-4.1A)
0.81A 4l1aB-3ttpA:
17.9
4l1aB-3ttpA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR


(Saccharomyces
cerevisiae)
PF00400
(WD40)
4 ARG A 146
ASN A 214
GLY A 220
THR A 151
None
1.06A 4l1aB-3w15A:
undetectable
4l1aB-3w15A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3s 6-PHOSPHOFRUCTOKINAS
E


(Bacillus
subtilis)
PF00365
(PFK)
4 ARG A 171
ASP A 134
GLY A 285
THR A 125
None
0.90A 4l1aB-4a3sA:
undetectable
4l1aB-4a3sA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE


(Hafnia alvei)
PF00328
(His_Phos_2)
4 ASN A 254
ASP A 307
GLY A 334
THR A 322
None
None
None
GOL  A1419 (-4.4A)
0.92A 4l1aB-4arsA:
undetectable
4l1aB-4arsA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
4 ASN A 315
ASP A 471
PRO A 216
THR A 212
None
0.97A 4l1aB-4eqvA:
undetectable
4l1aB-4eqvA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans)
PF00232
(Glyco_hydro_1)
4 ASN A 368
ASP A 375
PRO A 271
THR A 270
None
0.97A 4l1aB-4ha4A:
undetectable
4l1aB-4ha4A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN


(Ruegeria sp.
TM1040)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ARG A 221
ASN A 248
GLY A 352
PRO A  30
None
GOL  A 501 ( 3.8A)
None
GOL  A 501 ( 4.8A)
0.96A 4l1aB-4ip4A:
undetectable
4l1aB-4ip4A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is4 GLUTAMINE SYNTHETASE

(Medicago
truncatula)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
4 ASN A  61
GLY A  65
PRO A 103
THR A 104
None
1.07A 4l1aB-4is4A:
undetectable
4l1aB-4is4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED


(Xanthomonas
oryzae)
PF01053
(Cys_Met_Meta_PP)
4 ASP B 109
GLY B 367
PRO B 350
THR B 354
None
None
None
NAK  B 402 (-3.6A)
1.04A 4l1aB-4iyoB:
undetectable
4l1aB-4iyoB:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6f PUTATIVE ALCOHOL
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ARG A 310
ASP A  90
GLY A 137
PRO A 146
GOL  A 500 (-4.6A)
None
None
None
0.85A 4l1aB-4j6fA:
undetectable
4l1aB-4j6fA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN


(Pseudomonas
protegens)
PF13458
(Peripla_BP_6)
4 ASP A  76
GLY A  48
PRO A 126
THR A 125
None
1.04A 4l1aB-4maaA:
undetectable
4l1aB-4maaA:
15.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ARG A   8
ASP A  29
GLY A  48
PRO A  81
THR A  82
RIT  A 500 (-3.2A)
RIT  A 500 (-3.2A)
RIT  A 500 (-4.8A)
RIT  A 500 (-3.9A)
RIT  A 500 (-3.5A)
0.88A 4l1aB-4njvA:
17.7
4l1aB-4njvA:
87.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 ARG A   8
GLY A  52
PRO A  81
THR A  82
RIT  A 500 (-3.2A)
None
RIT  A 500 (-3.9A)
RIT  A 500 (-3.5A)
0.91A 4l1aB-4njvA:
17.7
4l1aB-4njvA:
87.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwv CAPSID PROTEIN

(Orsay virus)
PF11729
(Capsid-VNN)
4 ASP A 312
GLY A 243
PRO A 330
THR A 331
None
0.94A 4l1aB-4nwvA:
undetectable
4l1aB-4nwvA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nww CAPSID PROTEIN

(Orsay virus)
PF11729
(Capsid-VNN)
4 ASP A 312
GLY A 243
PRO A 330
THR A 331
None
0.94A 4l1aB-4nwwA:
undetectable
4l1aB-4nwwA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT


(Cupriavidus
necator)
PF03480
(DctP)
4 ARG A 165
ASP A 212
GLY A 230
THR A 235
None
1.08A 4l1aB-4p8bA:
undetectable
4l1aB-4p8bA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE


(Deinococcus
radiodurans)
PF02540
(NAD_synthase)
4 ARG A 136
ASN A 142
ASP A 182
GLY A 175
None
0.99A 4l1aB-4q16A:
undetectable
4l1aB-4q16A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn0 ENDONUCLEASE G,
MITOCHONDRIAL


(Caenorhabditis
elegans)
PF01223
(Endonuclease_NS)
4 ARG A 117
ASN A 154
GLY A 206
THR A 165
None
1.09A 4l1aB-4qn0A:
undetectable
4l1aB-4qn0A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3l MAJOR PILIN PROTEIN

(Streptococcus
pneumoniae)
no annotation 4 ASP A 120
GLY A 321
PRO A 277
THR A 276
None
0.99A 4l1aB-4s3lA:
undetectable
4l1aB-4s3lA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN


(Streptomyces
sp. SirexAA-E)
no annotation 4 ASN A 158
ASP A 204
GLY A 293
THR A 131
None
1.08A 4l1aB-4tz5A:
undetectable
4l1aB-4tz5A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfj ARGININOSUCCINATE
SYNTHASE


(Mycolicibacterium
thermoresistibile)
PF00764
(Arginosuc_synth)
4 ASP A 207
GLY A 346
PRO A 215
THR A 214
None
1.03A 4l1aB-4xfjA:
undetectable
4l1aB-4xfjA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR


(Streptobacillus
moniliformis)
PF13407
(Peripla_BP_4)
4 ASN A  68
ASP A 209
GLY A 173
PRO A  95
None
1.02A 4l1aB-4z0nA:
undetectable
4l1aB-4z0nA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE


(Streptococcus
pneumoniae)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
4 ASP A1177
GLY A1166
PRO A1214
THR A1215
None
1.03A 4l1aB-4z3oA:
undetectable
4l1aB-4z3oA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum)
PF07715
(Plug)
4 ASN A 135
ASP A 131
GLY A 315
THR A 365
None
None
LDA  A 901 (-3.9A)
None
0.99A 4l1aB-4zgvA:
undetectable
4l1aB-4zgvA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
4 ASN A1078
GLY A 889
PRO A 882
THR A 883
None
1.11A 4l1aB-4zktA:
undetectable
4l1aB-4zktA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zys EXOTOXIN 6

(Staphylococcus
aureus)
PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB)
4 ASN A  97
ASP A 156
GLY A 118
THR A  57
None
1.06A 4l1aB-4zysA:
undetectable
4l1aB-4zysA:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b18 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 ARG A   8
ASN A  25
ASP A  29
GLY A  48
None
0.57A 4l1aB-5b18A:
16.8
4l1aB-5b18A:
79.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b18 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 ARG A   8
ASN A  25
ASP A  29
PRO A  81
None
0.58A 4l1aB-5b18A:
16.8
4l1aB-5b18A:
79.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4w PLEXIN-B1

(Homo sapiens)
PF01403
(Sema)
PF01437
(PSI)
4 ASP A 456
GLY A  50
PRO A  30
THR A  29
None
0.95A 4l1aB-5b4wA:
undetectable
4l1aB-5b4wA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1r RV1816
TRANSCRIPTIONAL
REGULATOR


(Mycobacterium
tuberculosis)
PF00440
(TetR_N)
4 ARG A 100
ASP A 144
GLY A 149
THR A 224
None
1.06A 4l1aB-5d1rA:
undetectable
4l1aB-5d1rA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gve DNA TOPOISOMERASE
3-BETA-1


(Homo sapiens)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
4 ASN A 520
GLY A 189
PRO A 220
THR A 221
None
1.07A 4l1aB-5gveA:
undetectable
4l1aB-5gveA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE


(Zea mays)
PF00175
(NAD_binding_1)
4 ASP A  60
GLY A 110
PRO A 153
THR A  28
None
1.10A 4l1aB-5h5jA:
undetectable
4l1aB-5h5jA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC


(Zea mays)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
4 ARG A 124
ASP A 141
GLY A 430
THR A 155
CL  A 704 (-3.6A)
None
None
SRM  A 702 (-3.2A)
0.93A 4l1aB-5h8yA:
undetectable
4l1aB-5h8yA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8)
PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C)
4 ASP A 263
GLY A  90
PRO A 468
THR A 466
None
1.05A 4l1aB-5hqbA:
undetectable
4l1aB-5hqbA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kg9 ANTIBODY RE505-22
FAB LIGHT CHAIN


(Homo sapiens;
Mus musculus)
no annotation 4 ASN L 171
ASP L  82
GLY L  15
PRO L 110
None
0.92A 4l1aB-5kg9L:
undetectable
4l1aB-5kg9L:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE


(Enterobacter
cloacae)
PF00724
(Oxidored_FMN)
4 ASN A 128
GLY A 185
PRO A 148
THR A 147
None
1.10A 4l1aB-5lgxA:
undetectable
4l1aB-5lgxA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
4 ARG A1781
ASP A1793
GLY A1310
PRO A1210
None
1.07A 4l1aB-5m5pA:
undetectable
4l1aB-5m5pA:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 ARG A 510
ASN A 513
GLY A 312
PRO A 258
None
None
THR  A 601 ( 3.5A)
None
1.06A 4l1aB-5n9xA:
undetectable
4l1aB-5n9xA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8f NANOBODY NB25

(Lama glama)
no annotation 4 ASN L  77
ASP L  73
GLY L  55
PRO L  32
None
1.06A 4l1aB-5o8fL:
undetectable
4l1aB-5o8fL:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2


(Arabidopsis
thaliana)
PF00201
(UDPGT)
4 ASP A 440
GLY A 433
PRO A 224
THR A 225
None
1.10A 4l1aB-5u6sA:
undetectable
4l1aB-5u6sA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz HEMAGGLUTININ HA1
HEMAGGLUTININ HA2


(Influenza A
virus)
PF00509
(Hemagglutinin)
4 ASN A  15
ASP A  18
GLY A 320
THR B 515
NAG  A 408 (-1.8A)
None
None
None
0.98A 4l1aB-5ujzA:
undetectable
4l1aB-5ujzA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9)
4 ASP A 360
GLY A 356
PRO A 345
THR A 339
CA  A 501 (-2.5A)
None
None
None
1.11A 4l1aB-5vlhA:
undetectable
4l1aB-5vlhA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1


(Streptomyces
coelicolor)
PF00128
(Alpha-amylase)
PF11896
(DUF3416)
4 ARG A 648
ASN A 602
GLY A 490
THR A 654
None
0.97A 4l1aB-5vsjA:
undetectable
4l1aB-5vsjA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT


(Desulfovibrio
gigas)
no annotation 4 ARG B 178
ASN A 162
GLY A  13
THR A 166
None
None
FAD  A 701 (-3.5A)
None
0.97A 4l1aB-5xmjB:
undetectable
4l1aB-5xmjB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE


(Legionella
pneumophila)
no annotation 4 ASP A  98
GLY A 356
PRO A 339
THR A 343
None
None
None
FMT  A 401 (-3.6A)
1.05A 4l1aB-6cjbA:
undetectable
4l1aB-6cjbA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d8w HEMAGGLUTININ

(Influenza A
virus)
no annotation 4 ASN A  13
ASP A  16
GLY A 319
THR A 344
None
0.95A 4l1aB-6d8wA:
undetectable
4l1aB-6d8wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2


(Sus scrofa)
no annotation 4 ARG B 938
GLY B1024
PRO B1045
THR B1046
None
0.95A 4l1aB-6exvB:
undetectable
4l1aB-6exvB:
20.56