SIMILAR PATTERNS OF AMINO ACIDS FOR 4KUK_A_RBFA201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
12as ASPARAGINE
SYNTHETASE

(Escherichia
coli) 		PF03590
(AsnA) 		5 ILE A 140
ARG A  26
LEU A  27
ILE A 236
GLY A 292
 None
 1.06A 4kukA-12asA:
undetectable		 4kukA-12asA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byw PROTEIN (HUMAN ERG
POTASSIUM CHANNEL)

(Homo sapiens) 		PF13426
(PAS_9) 		5 LEU A  69
ILE A  82
LEU A  86
ILE A  96
PHE A 125
 None
 0.63A 4kukA-1bywA:
17.6		 4kukA-1bywA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqi PROTEIN
(SUCCINYL-COA
SYNTHETASE BETA
CHAIN)

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 VAL B 263
ILE B 318
ARG B 348
LEU B 349
GLY B 331
 None
 1.12A 4kukA-1cqiB:
undetectable		 4kukA-1cqiB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipk BETA-CONGLYCININ,
BETA CHAIN

(Glycine max) 		PF00190
(Cupin_1)
PF07883
(Cupin_2) 		5 VAL A  52
ILE A  51
ARG A  50
ILE A 123
GLY A 339
 None
 1.04A 4kukA-1ipkA:
undetectable		 4kukA-1ipkA:
15.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jnu PHY3 PROTEIN

(Adiantum
capillus-veneris) 		PF13426
(PAS_9) 		5 LEU A 969
VAL A 979
ILE A 982
PHE A1025
GLY A1027
 FMN  A1033 (-4.1A)
FMN  A1033 ( 4.9A)
FMN  A1033 (-4.3A)
FMN  A1033 ( 4.6A)
FMN  A1033 (-3.7A)
 0.41A 4kukA-1jnuA:
19.4		 4kukA-1jnuA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n9l PUTATIVE BLUE LIGHT
RECEPTOR

(Chlamydomonas
reinhardtii) 		PF13426
(PAS_9) 		5 LEU A  60
VAL A  70
ILE A  73
PHE A 116
GLY A 118
 FMN  A 500 (-4.3A)
FMN  A 500 (-4.3A)
FMN  A 500 ( 4.2A)
FMN  A 500 (-4.8A)
FMN  A 500 (-3.9A)
 0.34A 4kukA-1n9lA:
18.9		 4kukA-1n9lA:
36.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)

(Homo sapiens) 		PF00092
(VWA) 		5 VAL B 336
ILE B 335
LEU B 333
ILE B 337
GLY B 518
 None
 1.04A 4kukA-1qc5B:
undetectable		 4kukA-1qc5B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 VAL X 318
ILE X 319
LEU X 212
ILE X 281
GLY X 226
 None
 1.11A 4kukA-1r6bX:
undetectable		 4kukA-1r6bX:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 MET A 460
LEU A 508
ILE A 515
PHE A 403
GLY A 401
 None
 0.92A 4kukA-1rqgA:
undetectable		 4kukA-1rqgA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		5 VAL A 218
ILE A  98
LEU A  97
ILE A 214
GLY A 103
 None
 1.09A 4kukA-1t0bA:
undetectable		 4kukA-1t0bA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vq0 33 KDA CHAPERONIN

(Thermotoga
maritima) 		PF01430
(HSP33) 		5 LEU A  40
VAL A 104
ILE A 108
LEU A 131
ILE A  70
 None
 1.05A 4kukA-1vq0A:
undetectable		 4kukA-1vq0A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 VAL A 169
ILE A 173
ARG A 170
ILE A 241
GLY A 143
 None
None
None
None
EDO  A 503 (-3.7A)
 1.02A 4kukA-1x3lA:
undetectable		 4kukA-1x3lA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 LEU A 359
ILE A  89
ILE A  85
PHE A 342
GLY A 373
 None
 1.03A 4kukA-1zl6A:
undetectable		 4kukA-1zl6A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avd CATECHOL-O-METHYLTRA
NSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		5 MET A  86
LEU A 120
ILE A 156
PHE A 112
GLY A 110
 SAM  A 501 (-4.2A)
None
None
SAM  A 501 (-4.7A)
SAM  A 501 (-3.4A)
 1.10A 4kukA-2avdA:
undetectable		 4kukA-2avdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2x INTEGRIN ALPHA-1

(Rattus
norvegicus) 		PF00092
(VWA) 		5 VAL A 150
ILE A 149
LEU A 147
ILE A 151
GLY A 332
 None
 1.08A 4kukA-2b2xA:
undetectable		 4kukA-2b2xA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dch PUTATIVE HOMING
ENDONUCLEASE

(Thermoproteus) 		PF14528
(LAGLIDADG_3) 		5 VAL X  37
ILE X  36
LEU X   7
ILE X  33
GLY X  15
 None
 1.12A 4kukA-2dchX:
undetectable		 4kukA-2dchX:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		5 VAL A  57
ILE A  36
ARG A  35
LEU A  13
ILE A 351
 None
 1.08A 4kukA-2gd2A:
undetectable		 4kukA-2gd2A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II

(Thermotoga
maritima) 		PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C) 		5 LEU A 153
VAL A  88
ILE A  92
ILE A  91
GLY A 156
 None
 1.06A 4kukA-2hruA:
undetectable		 4kukA-2hruA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mwg BLUE-LIGHT
PHOTORECEPTOR

(Bacillus
subtilis) 		PF01740
(STAS)
PF13426
(PAS_9) 		6 LEU A  65
ILE A  78
ARG A  79
LEU A  82
ILE A  92
GLY A 121
 FMN  A 900 ( 4.1A)
FMN  A 900 ( 4.7A)
None
FMN  A 900 ( 4.8A)
FMN  A 900 ( 4.1A)
FMN  A 900 (-2.9A)
 1.17A 4kukA-2mwgA:
14.8		 4kukA-2mwgA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mwg BLUE-LIGHT
PHOTORECEPTOR

(Bacillus
subtilis) 		PF01740
(STAS)
PF13426
(PAS_9) 		7 LEU A  65
VAL A  75
ILE A  78
LEU A  82
ILE A  92
PHE A 119
GLY A 121
 FMN  A 900 ( 4.1A)
None
FMN  A 900 ( 4.7A)
FMN  A 900 ( 4.8A)
FMN  A 900 ( 4.1A)
None
FMN  A 900 (-2.9A)
 0.78A 4kukA-2mwgA:
14.8		 4kukA-2mwgA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pr5 BLUE-LIGHT
PHOTORECEPTOR

(Bacillus
subtilis) 		PF13426
(PAS_9) 		7 LEU A  65
VAL A  75
ILE A  78
LEU A  82
ILE A  92
PHE A 119
GLY A 121
 FMN  A 500 (-4.4A)
FMN  A 500 (-4.6A)
FMN  A 500 (-4.1A)
FMN  A 500 (-4.5A)
FMN  A 500 ( 4.6A)
FMN  A 500 ( 4.8A)
FMN  A 500 (-3.9A)
 0.24A 4kukA-2pr5A:
17.1		 4kukA-2pr5A:
33.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
putida) 		PF00106
(adh_short) 		5 LEU A 232
VAL A  85
ILE A 135
ILE A  83
GLY A 239
 None
 1.04A 4kukA-2q2vA:
undetectable		 4kukA-2q2vA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4y URIDYLATE KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		5 LEU A  47
VAL A  51
ILE A  12
LEU A 162
GLY A 232
 None
 1.05A 4kukA-2v4yA:
undetectable		 4kukA-2v4yA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 144
ILE A 208
LEU A 190
ILE A 155
GLY A 163
 None
None
None
None
EDO  A1510 (-3.4A)
 1.01A 4kukA-2w40A:
undetectable		 4kukA-2w40A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		5 LEU A 453
VAL A 463
ILE A 466
PHE A 509
GLY A 511
 FMN  A1725 (-4.2A)
FMN  A1725 (-4.6A)
FMN  A1725 (-4.2A)
None
FMN  A1725 (-3.7A)
 0.38A 4kukA-2wkpA:
18.0		 4kukA-2wkpA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		5 VAL A 481
ILE A 485
LEU A 515
PHE A 523
GLY A 500
 None
 1.09A 4kukA-2xdfA:
undetectable		 4kukA-2xdfA:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z6c PHOTOTROPIN-1

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		6 LEU A 237
ILE A 250
LEU A 254
ILE A 264
PHE A 293
GLY A 295
 FMN  A 500 (-4.4A)
FMN  A 500 (-4.1A)
FMN  A 500 (-4.7A)
None
None
FMN  A 500 (-3.9A)
 0.65A 4kukA-2z6cA:
16.6		 4kukA-2z6cA:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z6d PHOTOTROPIN-2

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		5 LEU A 173
VAL A 183
ILE A 186
PHE A 229
GLY A 231
 FMN  A 500 ( 4.4A)
FMN  A 500 ( 4.4A)
FMN  A 500 (-4.1A)
FMN  A 500 ( 4.5A)
FMN  A 500 (-3.7A)
 0.27A 4kukA-2z6dA:
19.1		 4kukA-2z6dA:
36.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqq METHYLGLUTACONYL-COA
HYDRATASE

(Homo sapiens) 		PF00378
(ECH_1) 		5 LEU A 118
VAL A 164
LEU A 107
ILE A 168
GLY A  93
 None
 1.12A 4kukA-2zqqA:
undetectable		 4kukA-2zqqA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akk CTKA

(Helicobacter
pylori) 		PF07804
(HipA_C) 		5 LEU A 150
ILE A 207
ARG A 206
LEU A 203
ILE A 282
 None
 1.02A 4kukA-3akkA:
undetectable		 4kukA-3akkA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		5 VAL A  66
ILE A 101
ARG A 102
ILE A  93
GLY A 144
 None
 1.11A 4kukA-3axxA:
undetectable		 4kukA-3axxA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dt8 BRAIN
PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
SUBUNIT ALPHA

(Bos taurus) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 136
VAL A 121
ILE A 120
LEU A  84
ILE A 117
 None
 1.11A 4kukA-3dt8A:
undetectable		 4kukA-3dt8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3few COLICIN S4

(Escherichia
coli) 		PF01024
(Colicin) 		5 LEU X 453
VAL X 313
ILE X 314
ILE X 317
GLY X 479
 None
 0.91A 4kukA-3fewX:
undetectable		 4kukA-3fewX:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 MET A  56
ILE A 321
LEU A 317
ILE A  85
GLY A  78
 None
 1.03A 4kukA-3ialA:
undetectable		 4kukA-3ialA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inn PANTOTHENATE
SYNTHETASE

(Brucella
melitensis) 		PF02569
(Pantoate_ligase) 		6 LEU A 212
VAL A 263
ILE A 261
ARG A 245
LEU A 253
ILE A 280
 None
 1.42A 4kukA-3innA:
undetectable		 4kukA-3innA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbe SUPEROXIDE DISMUTASE
[CU-ZN]

(Caenorhabditis
elegans) 		PF00080
(Sod_Cu) 		5 LEU A  98
ILE A  34
LEU A  37
ILE A  17
GLY A  43
 None
 0.99A 4kukA-3kbeA:
undetectable		 4kukA-3kbeA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens) 		PF03483
(B3_4)
PF03484
(B5) 		5 LEU B  77
VAL B  67
ARG B  71
ILE B  65
PHE B  87
 None
 1.08A 4kukA-3l4gB:
undetectable		 4kukA-3l4gB:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		5 MET A 191
ILE A 305
ARG A 279
LEU A 116
ILE A 331
 None
 0.83A 4kukA-3ll8A:
undetectable		 4kukA-3ll8A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw2 NEUREXIN-1-ALPHA

(Mus musculus) 		PF02210
(Laminin_G_2) 		5 VAL A 268
LEU A 258
ILE A 279
PHE A 254
GLY A  94
 None
 0.91A 4kukA-3mw2A:
undetectable		 4kukA-3mw2A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw4 NEUREXIN-2-BETA

(Mus musculus) 		PF02210
(Laminin_G_2) 		6 LEU A  95
VAL A 236
LEU A 226
ILE A 247
PHE A 222
GLY A  92
 None
 1.16A 4kukA-3mw4A:
undetectable		 4kukA-3mw4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncy ADIC

(Salmonella
enterica) 		PF13520
(AA_permease_2) 		5 LEU A 388
VAL A  59
LEU A  66
ILE A 390
GLY A 381
 None
 1.11A 4kukA-3ncyA:
undetectable		 4kukA-3ncyA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)

(Rhodobacter
sphaeroides) 		PF00588
(SpoU_methylase) 		5 VAL A  36
ILE A  35
ARG A  34
LEU A  33
GLY A  19
 None
None
BME  A 254 (-3.3A)
None
None
 0.92A 4kukA-3onpA:
undetectable		 4kukA-3onpA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7n SENSOR HISTIDINE
KINASE

(Erythrobacter
litoralis) 		PF00196
(GerE)
PF13426
(PAS_9) 		5 LEU A  78
ILE A  91
ILE A 105
PHE A 134
GLY A 136
 FMN  A 500 (-4.6A)
FMN  A 500 (-3.9A)
FMN  A 500 (-4.1A)
None
FMN  A 500 ( 4.0A)
 0.38A 4kukA-3p7nA:
19.3		 4kukA-3p7nA:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		5 VAL A1314
LEU A1304
ILE A1325
PHE A1300
GLY A1140
 None
 0.94A 4kukA-3qcwA:
undetectable		 4kukA-3qcwA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9p ACKA

(Mycobacterium
avium) 		PF00871
(Acetate_kinase) 		6 LEU A 338
VAL A 366
ILE A 314
ARG A 328
LEU A 196
ILE A 364
 None
None
None
GOL  A 388 ( 4.2A)
None
None
 1.16A 4kukA-3r9pA:
undetectable		 4kukA-3r9pA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt PLEXIN-A1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 LEU A1720
ILE A1713
LEU A1447
ILE A1818
PHE A1747
 None
 1.10A 4kukA-3rytA:
undetectable		 4kukA-3rytA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 VAL A 110
ILE A 212
LEU A 271
ILE A 108
GLY A 348
 None
 1.07A 4kukA-3sunA:
undetectable		 4kukA-3sunA:
9.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t50 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE

(Brucella
melitensis) 		PF13426
(PAS_9) 		5 LEU A  72
VAL A  82
ILE A  85
ILE A  99
PHE A 128
 FMN  A 200 (-4.3A)
FMN  A 200 (-4.3A)
FMN  A 200 (-4.2A)
FMN  A 200 ( 4.4A)
FMN  A 200 (-4.5A)
 0.24A 4kukA-3t50A:
19.5		 4kukA-3t50A:
39.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb6 ARABINOSE METABOLISM
TRANSCRIPTIONAL
REPRESSOR

(Bacillus
subtilis) 		PF13377
(Peripla_BP_3) 		5 LEU A  85
ILE A 101
LEU A 105
ILE A 169
GLY A 138
 None
 1.11A 4kukA-3tb6A:
undetectable		 4kukA-3tb6A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		5 VAL A  66
ILE A 101
ARG A 102
ILE A  93
GLY A 144
 None
 1.12A 4kukA-3w6mA:
undetectable		 4kukA-3w6mA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 VAL A 172
ILE A 291
ILE A 306
PHE A 178
GLY A 141
 None
 0.99A 4kukA-3w9iA:
undetectable		 4kukA-3w9iA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		5 MET A 231
VAL A 353
ILE A 356
LEU A 360
ILE A 327
 None
 1.07A 4kukA-3wfoA:
undetectable		 4kukA-3wfoA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(Aquifex
aeolicus;
synthetic
construct) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		5 MET A 231
VAL A 353
ILE A 356
LEU A 360
ILE A 327
 None
 1.06A 4kukA-3wfpA:
undetectable		 4kukA-3wfpA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4abk POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF01661
(Macro) 		5 VAL A1258
ILE A1262
LEU A1263
ILE A1236
GLY A1290
 AR6  A2389 (-3.9A)
None
None
AR6  A2389 (-3.9A)
None
 1.11A 4kukA-4abkA:
undetectable		 4kukA-4abkA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d82 AAA ATPASE, CENTRAL
DOMAIN PROTEIN

(Metallosphaera
sedula) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 278
VAL A 313
ILE A 312
LEU A 344
GLY A 303
 None
 1.09A 4kukA-4d82A:
undetectable		 4kukA-4d82A:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ees PHOTOTROPIN-2

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		5 LEU A 429
VAL A 439
ILE A 442
PHE A 485
GLY A 487
 FMN  A1001 (-4.2A)
FMN  A1001 (-4.5A)
FMN  A1001 (-4.1A)
FMN  A1001 (-4.6A)
FMN  A1001 (-3.8A)
 0.26A 4kukA-4eesA:
20.2		 4kukA-4eesA:
34.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		5 LEU A  32
VAL A  17
ILE A  41
ARG A  40
ILE A  15
 None
 1.11A 4kukA-4f3eA:
undetectable		 4kukA-4f3eA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcz BLUE-LIGHT
PHOTORECEPTOR,
SENSOR PROTEIN FIXL

(Bacillus
subtilis;
Bradyrhizobium
diazoefficiens) 		PF00512
(HisKA)
PF02518
(HATPase_c)
PF13426
(PAS_9) 		7 LEU A  65
VAL A  75
ILE A  78
LEU A  82
ILE A  92
PHE A 119
GLY A 121
 FMN  A 401 (-4.5A)
FMN  A 401 ( 4.6A)
FMN  A 401 (-4.1A)
FMN  A 401 (-4.5A)
FMN  A 401 ( 4.6A)
FMN  A 401 (-4.7A)
FMN  A 401 (-3.7A)
 0.40A 4kukA-4gczA:
17.7		 4kukA-4gczA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h08 PUTATIVE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF00657
(Lipase_GDSL) 		5 VAL A 216
ILE A 217
LEU A  65
ILE A 138
GLY A  72
 None
 1.13A 4kukA-4h08A:
undetectable		 4kukA-4h08A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0o ACETATE KINASE

(Entamoeba
histolytica) 		PF00871
(Acetate_kinase) 		5 VAL A 331
ILE A 335
LEU A 318
ILE A 298
GLY A 306
 None
 0.76A 4kukA-4h0oA:
undetectable		 4kukA-4h0oA:
14.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hhd PHOTOTROPIN-1

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		6 LEU A 515
VAL A 525
ILE A 528
ARG A 529
PHE A 571
GLY A 573
 FMN  A 701 (-4.4A)
FMN  A 701 (-4.9A)
FMN  A 701 ( 4.1A)
None
FMN  A 701 (-4.9A)
FMN  A 701 (-3.7A)
 0.80A 4kukA-4hhdA:
19.2		 4kukA-4hhdA:
32.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hj3 LOV PROTEIN

(Rhodobacter
sphaeroides) 		PF13426
(PAS_9) 		5 LEU A  58
ILE A  71
LEU A  75
PHE A 114
GLY A 116
 FMN  A 201 (-4.4A)
FMN  A 201 ( 4.0A)
FMN  A 201 ( 4.7A)
None
FMN  A 201 (-3.9A)
 0.94A 4kukA-4hj3A:
15.0		 4kukA-4hj3A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		5 VAL A1343
ILE A1342
LEU A1163
ILE A1201
GLY A1210
 None
 1.09A 4kukA-4i3hA:
undetectable		 4kukA-4i3hA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijn ACETATE KINASE

(Mycolicibacterium
smegmatis) 		PF00871
(Acetate_kinase) 		5 LEU A 330
VAL A 358
ILE A 306
ARG A 320
LEU A 188
 None
 1.09A 4kukA-4ijnA:
undetectable		 4kukA-4ijnA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		5 MET A 524
ILE A 638
ARG A 612
LEU A 449
ILE A 664
 None
 1.00A 4kukA-4il1A:
undetectable		 4kukA-4il1A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln1 L-LACTATE
DEHYDROGENASE 1

(Bacillus cereus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A 243
ILE A 247
LEU A 248
ILE A 144
GLY A 116
 None
 1.11A 4kukA-4ln1A:
undetectable		 4kukA-4ln1A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		5 LEU A 113
VAL A 293
ILE A  74
LEU A  14
GLY A  55
 None
 1.01A 4kukA-4m2gA:
undetectable		 4kukA-4m2gA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orb SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Mus musculus) 		PF00149
(Metallophos) 		5 MET A 191
ILE A 305
ARG A 279
LEU A 116
ILE A 331
 None
 0.85A 4kukA-4orbA:
undetectable		 4kukA-4orbA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 LEU A 300
VAL A 305
ILE A 270
LEU A 280
GLY A 542
 None
 0.98A 4kukA-4ox2A:
undetectable		 4kukA-4ox2A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p52 HOMOSERINE KINASE

(Cytophaga
hutchinsonii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A  70
VAL A 107
ILE A 110
LEU A 114
GLY A  81
 None
 0.98A 4kukA-4p52A:
undetectable		 4kukA-4p52A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Chromobacterium
violaceum) 		PF04348
(LppC) 		5 VAL A 145
ILE A 146
LEU A 168
ILE A  86
GLY A 107
 None
 1.06A 4kukA-4pyrA:
undetectable		 4kukA-4pyrA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qez 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Bacillus
anthracis) 		no annotation 5 ARG B  96
LEU B 169
ILE B 192
PHE B  80
GLY B  78
 None
None
None
None
ADE  B 301 (-3.2A)
 1.08A 4kukA-4qezB:
undetectable		 4kukA-4qezB:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF13426
(PAS_9) 		5 LEU A  58
VAL A  68
ILE A  85
PHE A 114
GLY A 116
 RBF  A 201 (-3.9A)
RBF  A 201 (-3.3A)
RBF  A 201 ( 4.2A)
RBF  A 201 (-4.4A)
RBF  A 201 ( 3.3A)
 0.58A 4kukA-4r38A:
18.4		 4kukA-4r38A:
36.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		5 LEU A  58
VAL A  68
ILE A  85
PHE A 114
GLY A 116
 RBF  A 402 (-4.2A)
RBF  A 402 (-3.5A)
RBF  A 402 (-4.0A)
RBF  A 402 ( 4.3A)
RBF  A 402 ( 3.8A)
 0.42A 4kukA-4r3aA:
14.6		 4kukA-4r3aA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		5 LEU A 264
VAL A 222
ILE A 226
ARG A 223
ILE A 239
 None
 1.07A 4kukA-4r3uA:
undetectable		 4kukA-4r3uA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uar PROTEIN CBBY

(Rhodobacter
sphaeroides) 		PF13419
(HAD_2) 		5 ILE A   5
LEU A 174
ILE A 109
PHE A 214
GLY A 219
 None
 1.11A 4kukA-4uarA:
undetectable		 4kukA-4uarA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		5 LEU A 694
ILE A 741
ARG A 740
LEU A 739
PHE A 715
 None
 0.94A 4kukA-4ufcA:
undetectable		 4kukA-4ufcA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE

(Zophobas
atratus) 		PF00501
(AMP-binding) 		5 LEU A  87
VAL A  58
ARG A  57
PHE A  25
GLY A  21
 None
 1.10A 4kukA-4w8oA:
undetectable		 4kukA-4w8oA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Sinorhizobium
meliloti) 		PF00496
(SBP_bac_5) 		5 VAL A 384
ILE A 385
LEU A 396
ILE A 305
GLY A 418
 None
 1.01A 4kukA-4wedA:
undetectable		 4kukA-4wedA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE

(Homo sapiens) 		PF01207
(Dus) 		5 VAL A 182
ILE A 156
ARG A 157
LEU A 131
ILE A 180
 None
None
SO4  A 403 (-4.2A)
None
None
 0.96A 4kukA-4wfsA:
undetectable		 4kukA-4wfsA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN

(Homo sapiens) 		PF10421
(OAS1_C) 		5 LEU A  34
ILE A 140
LEU A 118
ILE A 149
PHE A  43
 None
 1.08A 4kukA-4xq7A:
undetectable		 4kukA-4xq7A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A  42
LEU A 174
ILE A 307
PHE A 115
GLY A 316
 None
 1.07A 4kukA-4zk3A:
undetectable		 4kukA-4zk3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 LEU A 360
ILE A  90
ILE A  86
PHE A 343
GLY A 374
 None
 1.11A 4kukA-4zktA:
undetectable		 4kukA-4zktA:
7.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a8b PTAUREO1A LOV2
DOMAIN

(Phaeodactylum
tricornutum) 		PF13426
(PAS_9) 		5 LEU A 290
VAL A 300
ILE A 303
PHE A 346
GLY A 348
 FMN  A 500 (-4.0A)
None
FMN  A 500 ( 4.1A)
FMN  A 500 (-4.8A)
FMN  A 500 (-3.8A)
 0.58A 4kukA-5a8bA:
19.3		 4kukA-5a8bA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 VAL A  92
ILE A  88
ARG A  89
ILE A  94
GLY A  83
 None
 1.05A 4kukA-5demA:
undetectable		 4kukA-5demA:
17.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dju NPH1-2

(Avena sativa) 		PF13426
(PAS_9) 		6 LEU A 453
VAL A 463
ILE A 466
ARG A 467
PHE A 509
GLY A 511
 FMN  A 601 (-4.0A)
FMN  A 601 (-4.6A)
FMN  A 601 ( 4.4A)
None
None
FMN  A 601 (-3.8A)
 0.82A 4kukA-5djuA:
17.3		 4kukA-5djuA:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dkk LOV DOMAIN

(Phaeodactylum
tricornutum) 		PF13426
(PAS_9) 		5 LEU A 290
VAL A 300
ILE A 303
PHE A 346
GLY A 348
 FMN  A 401 (-4.1A)
FMN  A 401 (-4.4A)
FMN  A 401 (-4.2A)
FMN  A 401 (-4.8A)
FMN  A 401 (-3.7A)
 0.53A 4kukA-5dkkA:
19.4		 4kukA-5dkkA:
36.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 MET A 472
VAL A 236
ILE A 239
ILE A 354
GLY A 465
 None
 1.09A 4kukA-5e4rA:
undetectable		 4kukA-5e4rA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		5 LEU A 100
VAL A 110
ILE A 113
PHE A 156
GLY A 158
 FMN  A 402 (-4.1A)
FMN  A 402 (-4.5A)
FMN  A 402 (-4.3A)
FMN  A 402 (-4.9A)
FMN  A 402 (-3.7A)
 0.39A 4kukA-5hzhA:
17.7		 4kukA-5hzhA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1

(Avena sativa;
Homo sapiens) 		PF00621
(RhoGEF)
PF13426
(PAS_9)
PF16652
(PH_13) 		5 LEU B1358
VAL B1368
ILE B1371
PHE B1414
GLY B1416
 FMN  B1801 (-4.2A)
FMN  B1801 (-4.5A)
FMN  B1801 (-4.1A)
FMN  B1801 (-4.8A)
FMN  B1801 (-3.7A)
 0.41A 4kukA-5hzkB:
17.9		 4kukA-5hzkB:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 VAL A 445
ILE A 448
LEU A 452
ILE A 413
GLY A 405
 None
 1.07A 4kukA-5lq3A:
undetectable		 4kukA-5lq3A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L21,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00829
(Ribosomal_L21p) 		5 VAL T 186
ILE T 219
ARG T 218
ILE T 156
GLY T 130
 None
None
None
None
U  A1188 ( 3.3A)
 1.05A 4kukA-5mlcT:
undetectable		 4kukA-5mlcT:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 5 LEU A 426
VAL A 413
ILE A 416
ILE A 505
GLY A 547
 None
 0.81A 4kukA-5n94A:
undetectable		 4kukA-5n94A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t77 PUTATIVE LIPID II
FLIPPASE MURJ

(Thermosipho
africanus) 		PF03023
(MVIN) 		5 LEU A 156
ILE A 163
ILE A 160
PHE A  23
GLY A  21
 OLC  A 527 ( 4.5A)
None
OLC  A 527 ( 4.7A)
OLC  A 536 (-3.3A)
None
 1.08A 4kukA-5t77A:
undetectable		 4kukA-5t77A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uin FORMYLTRANSFERASE

(Salmonella
enterica) 		PF00551
(Formyl_trans_N)
PF13637
(Ank_4) 		5 MET A 348
VAL A 308
ILE A 320
ILE A 330
GLY A 356
 None
 1.08A 4kukA-5uinA:
undetectable		 4kukA-5uinA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 5 LEU A 396
VAL A  81
ILE A  84
LEU A  88
GLY A 366
 None
None
None
None
HEM  A 501 ( 4.5A)
 0.98A 4kukA-5wbgA:
undetectable		 4kukA-5wbgA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus) 		no annotation 5 VAL M  35
ILE M  34
ARG M  38
ILE M  31
GLY M  81
 None
 1.11A 4kukA-5x41M:
undetectable		 4kukA-5x41M:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 LEU A 353
VAL A 339
ILE A 342
ILE A 437
GLY A 479
 None
 0.83A 4kukA-5xdrA:
undetectable		 4kukA-5xdrA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 5 LEU A 510
VAL A 497
ILE A 500
ILE A 588
GLY A 632
 None
 0.83A 4kukA-6fa5A:
undetectable		 4kukA-6fa5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbv PUTATIVE BLUE-LIGHT
PHOTORECEPTOR

(Dinoroseobacter
shibae) 		no annotation 8 LEU A  75
VAL A  85
ILE A  88
ARG A  89
LEU A  92
ILE A 102
PHE A 131
GLY A 133
 FMN  A 500 (-4.0A)
FMN  A 500 (-4.3A)
FMN  A 500 (-4.1A)
None
FMN  A 500 (-4.6A)
FMN  A 500 ( 4.3A)
FMN  A 500 (-4.8A)
FMN  A 500 (-3.9A)
 0.29A 4kukA-6gbvA:
25.8		 4kukA-6gbvA:
undetectable