SIMILAR PATTERNS OF AMINO ACIDS FOR 4KTV_C_ADNC403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tiz CALMODULIN-RELATED
PROTEIN, PUTATIVE

(Arabidopsis
thaliana) 		PF13499
(EF-hand_7) 		5 SER A  61
ASP A  49
ASP A  57
ASP A  47
ILE A  46
 None
 1.48A 4ktvC-1tizA:
undetectable
4ktvD-1tizA:
undetectable		 4ktvC-1tizA:
9.39
4ktvD-1tizA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umr CONVULXIN ALPHA

(Crotalus
durissus) 		PF00059
(Lectin_C) 		5 HIS A  14
LYS A 130
ASP A  12
ASP A  51
ILE A  44
 None
 1.35A 4ktvC-1umrA:
undetectable
4ktvD-1umrA:
undetectable		 4ktvC-1umrA:
15.21
4ktvD-1umrA:
15.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  14
PRO A  15
ASP A 163
LYS A 165
PHE A 230
ASP A 238
 None
 0.53A 4ktvC-1xrcA:
51.8
4ktvD-1xrcA:
53.9		 4ktvC-1xrcA:
54.70
4ktvD-1xrcA:
54.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		5 ASP A 403
SER A 353
ASP A 442
ILE A 389
ASP A 370
 None
None
None
None
SO4  A1000 (-3.0A)
 1.17A 4ktvC-1yp4A:
undetectable
4ktvD-1yp4A:
undetectable		 4ktvC-1yp4A:
23.06
4ktvD-1yp4A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auc MYOSIN A TAIL
INTERACTING PROTEIN

(Plasmodium
knowlesi) 		PF13405
(EF-hand_6) 		5 SER A  97
ASP A 117
ASP A 111
ILE A 115
ILE A  93
 None
 1.32A 4ktvC-2aucA:
undetectable
4ktvD-2aucA:
undetectable		 4ktvC-2aucA:
15.23
4ktvD-2aucA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		5 SER A 232
ASP A 271
ILE A 248
ASP A 219
ILE A 220
 None
 1.45A 4ktvC-2bb0A:
undetectable
4ktvD-2bb0A:
undetectable		 4ktvC-2bb0A:
24.03
4ktvD-2bb0A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		5 HIS A 106
PRO A 174
ASP A 387
ASP A 208
ILE A 285
 VO4  A 801 (-3.8A)
VO4  A 801 (-4.1A)
UNX  A 601 ( 2.6A)
VO4  A 801 (-2.6A)
None
 1.38A 4ktvC-2d1gA:
undetectable
4ktvD-2d1gA:
undetectable		 4ktvC-2d1gA:
21.97
4ktvD-2d1gA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 247
PHE A 250
ASP A 258
 SAM  A 501 (-3.6A)
SAM  A 501 (-4.2A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.9A)
SAM  A 501 (-2.8A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.6A)
 0.35A 4ktvC-2obvA:
55.9
4ktvD-2obvA:
62.1		 4ktvC-2obvA:
85.68
4ktvD-2obvA:
85.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsf DNA REPAIR PROTEIN
RAD4

(Saccharomyces
cerevisiae) 		PF03835
(Rad4)
PF10403
(BHD_1)
PF10405
(BHD_3) 		5 PRO A 332
ASP A 331
SER A 285
ASP A 263
ILE A 314
 None
 1.47A 4ktvC-2qsfA:
undetectable
4ktvD-2qsfA:
undetectable		 4ktvC-2qsfA:
22.31
4ktvD-2qsfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 HIS A 337
SER A  34
ASP A 308
ASP A  68
ILE A  69
 None
 1.21A 4ktvC-2vr5A:
undetectable
4ktvD-2vr5A:
undetectable		 4ktvC-2vr5A:
18.68
4ktvD-2vr5A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		5 HIS A 370
PHE A 289
ASP A 339
ILE A 336
ILE A 342
 None
 1.50A 4ktvC-3a9gA:
undetectable
4ktvD-3a9gA:
undetectable		 4ktvC-3a9gA:
24.48
4ktvD-3a9gA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 28 KDA FORM
PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM

(Mus musculus) 		PF04916
(Phospholip_B) 		5 PRO B 410
PHE A 163
ASP A 230
ASP A 227
ILE A 224
 None
 1.23A 4ktvC-3fgtB:
undetectable
4ktvD-3fgtB:
undetectable		 4ktvC-3fgtB:
20.37
4ktvD-3fgtB:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 HIS A  16
PRO A  17
ASP A 167
LYS A 169
PHE A 234
 None
 0.31A 4ktvC-3imlA:
50.4
4ktvD-3imlA:
51.8		 4ktvC-3imlA:
53.49
4ktvD-3imlA:
53.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 PRO A 174
ASP A 136
PHE A 134
ASP A 107
ASP A 122
 None
 1.50A 4ktvC-3lq1A:
undetectable
4ktvD-3lq1A:
undetectable		 4ktvC-3lq1A:
23.28
4ktvD-3lq1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		5 HIS A 339
ASP A 156
ASP A  13
ASP A 243
ILE A 244
 MN  A 395 (-3.4A)
MN  A 395 (-2.1A)
MN  A 396 (-2.0A)
None
TPO  A  85 ( 4.3A)
 1.36A 4ktvC-3m8yA:
undetectable
4ktvD-3m8yA:
undetectable		 4ktvC-3m8yA:
24.29
4ktvD-3m8yA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		5 ASP A  77
PHE A 172
ASP A 201
ILE A 199
ILE A 195
 MN3  A1001 (-2.2A)
MN3  A1001 ( 4.5A)
None
None
None
 1.28A 4ktvC-3mjoA:
undetectable
4ktvD-3mjoA:
undetectable		 4ktvC-3mjoA:
20.35
4ktvD-3mjoA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm9 PUTATIVE
OXIDOREDUCTASE

(Rhodopseudomonas
palustris) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 HIS A 387
ASP A 390
SER A 429
ILE A 355
ASP A 354
 UNL  A 477 ( 3.7A)
None
None
None
None
 1.32A 4ktvC-3pm9A:
undetectable
4ktvD-3pm9A:
undetectable		 4ktvC-3pm9A:
23.40
4ktvD-3pm9A:
23.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  17
PRO A  18
ASP A 179
LYS A 181
PHE A 251
ASP A 259
 None
None
None
None
None
CA  A 404 (-3.4A)
 0.70A 4ktvC-3rv2A:
51.1
4ktvD-3rv2A:
49.8		 4ktvC-3rv2A:
53.55
4ktvD-3rv2A:
53.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  16
PRO A  17
ASP A 166
LYS A 168
PHE A 237
ASP A 245
 None
None
None
ACT  A 400 ( 4.9A)
None
None
 0.65A 4ktvC-3so4A:
53.4
4ktvD-3so4A:
55.3		 4ktvC-3so4A:
60.77
4ktvD-3so4A:
60.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  16
PRO A  17
ASP A 166
LYS A 168
SER A 234
PHE A 237
 None
None
None
ACT  A 400 ( 4.9A)
None
None
 0.46A 4ktvC-3so4A:
53.4
4ktvD-3so4A:
55.3		 4ktvC-3so4A:
60.77
4ktvD-3so4A:
60.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tat TYROSINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 SER A 255
ASP A 236
ASP A 222
ILE A 223
ILE A 259
 PLP  A 500 ( 4.0A)
None
PLP  A 500 (-3.7A)
None
None
 1.50A 4ktvC-3tatA:
undetectable
4ktvD-3tatA:
undetectable		 4ktvC-3tatA:
22.20
4ktvD-3tatA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD

(Thermococcus
kodakarensis) 		PF01924
(HypD) 		5 PRO B 317
ASP B 318
ASP B  75
ILE B  76
ILE B 104
 None
 1.45A 4ktvC-3vysB:
undetectable
4ktvD-3vysB:
undetectable		 4ktvC-3vysB:
23.57
4ktvD-3vysB:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di5 5-EPI-ARISTOLOCHENE
SYNTHASE

(Nicotiana
tabacum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 PRO A 123
SER A 171
PHE A 136
ASP A 161
ASP A 166
 None
 1.40A 4ktvC-4di5A:
undetectable
4ktvD-4di5A:
undetectable		 4ktvC-4di5A:
22.22
4ktvD-4di5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzn BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14859
(Colicin_M) 		5 PRO A 121
SER A 110
ASP A 106
ILE A 107
ILE A 117
 None
 1.46A 4ktvC-4fznA:
undetectable
4ktvD-4fznA:
undetectable		 4ktvC-4fznA:
22.33
4ktvD-4fznA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		5 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.88A 4ktvC-4hpvA:
25.2
4ktvD-4hpvA:
27.4		 4ktvC-4hpvA:
24.95
4ktvD-4hpvA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE

(Thermococcus
kodakarensis) 		PF01941
(AdoMet_Synthase) 		5 HIS A  33
PRO A  34
ASP A 201
LYS A 203
ASP A 283
 None
 0.97A 4ktvC-4l4qA:
26.0
4ktvD-4l4qA:
27.9		 4ktvC-4l4qA:
25.06
4ktvD-4l4qA:
25.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 HIS A  13
PRO A  14
ASP A 168
LYS A 170
ASP A 250
 None
 0.46A 4ktvC-4le5A:
46.4
4ktvD-4le5A:
48.8		 4ktvC-4le5A:
38.48
4ktvD-4le5A:
38.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odj S-ADENOSYLMETHIONINE
SYNTHASE

(Cryptosporidium
hominis) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  34
PRO A  35
ASP A 187
LYS A 189
SER A 255
PHE A 258
ASP A 266
 SAM  A 500 ( 3.8A)
SAM  A 500 (-4.3A)
SAM  A 500 (-2.8A)
3PO  A 501 ( 2.7A)
SAM  A 500 (-2.7A)
SAM  A 500 (-3.5A)
SAM  A 500 (-3.3A)
 0.43A 4ktvC-4odjA:
52.8
4ktvD-4odjA:
58.8		 4ktvC-4odjA:
56.28
4ktvD-4odjA:
56.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 PRO A 369
LYS A 373
SER A 381
ASP A 501
ILE A 500
 None
 1.48A 4ktvC-4qg5A:
undetectable
4ktvD-4qg5A:
undetectable		 4ktvC-4qg5A:
21.11
4ktvD-4qg5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v06 TRYPTOPHAN
5-HYDROXYLASE 2

(Homo sapiens) 		PF00351
(Biopterin_H) 		5 HIS A 318
PRO A 314
SER A 336
PHE A 296
ILE A 362
 FE  A1491 ( 3.5A)
IMD  A 600 ( 4.7A)
None
IMD  A 600 (-4.7A)
None
 1.22A 4ktvC-4v06A:
undetectable
4ktvD-4v06A:
undetectable		 4ktvC-4v06A:
20.49
4ktvD-4v06A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuj GLYCOSIDE HYDROLASE
FAMILY 15, CELLULOSE
SIGNALING ASSOCIATED
PROTEIN ENVOY

(Trichoderma
reesei) 		PF13426
(PAS_9) 		5 HIS A 197
ASP A 104
ASP A 193
ILE A  77
ILE A  72
 None
 1.42A 4ktvC-4wujA:
undetectable
4ktvD-4wujA:
undetectable		 4ktvC-4wujA:
16.39
4ktvD-4wujA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp. BTAi1) 		PF13407
(Peripla_BP_4) 		5 HIS A 321
PRO A  36
ASP A 154
ASP A 145
ILE A 150
 None
 1.44A 4ktvC-4yhsA:
undetectable
4ktvD-4yhsA:
undetectable		 4ktvC-4yhsA:
21.79
4ktvD-4yhsA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.46A 4ktvC-5a1iA:
55.6
4ktvD-5a1iA:
62.0		 4ktvC-5a1iA:
100.00
4ktvD-5a1iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 5 HIS C  16
PRO C  17
ASP C 175
PHE C 243
ASP C 251
 None
 0.77A 4ktvC-5h9uC:
52.2
4ktvD-5h9uC:
54.6		 4ktvC-5h9uC:
51.57
4ktvD-5h9uC:
51.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 5 HIS C  16
PRO C  17
ASP C 175
SER C 240
PHE C 243
 None
 0.53A 4ktvC-5h9uC:
52.2
4ktvD-5h9uC:
54.6		 4ktvC-5h9uC:
51.57
4ktvD-5h9uC:
51.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 HIS A 317
ASP A 287
ASP A   8
ILE A   5
ILE A  15
 TRS  A 402 (-4.3A)
None
None
None
None
 1.23A 4ktvC-5hc4A:
undetectable
4ktvD-5hc4A:
undetectable		 4ktvC-5hc4A:
22.09
4ktvD-5hc4A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 5 HIS A 137
SER A 188
PHE A 184
ASP A 162
ILE A 159
 GOL  A 654 (-4.3A)
None
None
GOL  A 654 (-2.9A)
None
 1.21A 4ktvC-5jvkA:
undetectable
4ktvD-5jvkA:
undetectable		 4ktvC-5jvkA:
20.97
4ktvD-5jvkA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 HIS A  15
PRO A  16
ASP A 166
LYS A 168
PHE A 235
 None
 0.60A 4ktvC-5t8tA:
11.2
4ktvD-5t8tA:
55.7		 4ktvC-5t8tA:
56.05
4ktvD-5t8tA:
56.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 HIS A  15
PRO A  16
ASP A 166
PHE A 235
ASP A 243
 None
 0.63A 4ktvC-5t8tA:
11.2
4ktvD-5t8tA:
55.7		 4ktvC-5t8tA:
56.05
4ktvD-5t8tA:
56.05