SIMILAR PATTERNS OF AMINO ACIDS FOR 4KT0_A_PQNA2001

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1agx	GLUTAMINASE-ASPARAGI NASE (Acinetobacter glutaminasificans)	PF00710 (Asparaginase)	5	GLY A 179 ALA A 159 GLY A 182 ILE A   6 LEU A  36	None	1.03A	4kt0A-1agxA: undetectable 4kt0J-1agxA: 0.0	4kt0A-1agxA: 19.65 4kt0J-1agxA: 8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1aor	ALDEHYDE FERREDOXIN OXIDOREDUCTASE (Pyrococcus furiosus)	PF01314 (AFOR_C) PF02730 (AFOR_N)	5	GLY A  68 ALA A  63 GLY A   3 ILE A 601 LEU A 599	None	0.93A	4kt0A-1aorA: undetectable 4kt0J-1aorA: undetectable	4kt0A-1aorA: 22.10 4kt0J-1aorA: 5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1dlp	LECTIN SCAFET PRECURSOR (Hyacinthoides hispanica)	PF01453 (B_lectin)	5	SER A  81 GLY A  82 TRP A 233 GLY A  66 LEU A 147	None	1.06A	4kt0A-1dlpA: undetectable 4kt0J-1dlpA: undetectable	4kt0A-1dlpA: 15.85 4kt0J-1dlpA: 11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1fpq	ISOLIQUIRITIGENIN 2'-O-METHYLTRANSFERA SE (Medicago sativa)	PF00891 (Methyltransf_2) PF08100 (Dimerisation)	5	PHE A  50 GLY A 115 ALA A  93 GLY A 120 LEU A 145	None	1.09A	4kt0A-1fpqA: undetectable 4kt0J-1fpqA: 0.0	4kt0A-1fpqA: 19.61 4kt0J-1fpqA: 6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1iy1	ATP-DEPENDENT METALLOPROTEASE FTSH (Thermus thermophilus)	PF00004 (AAA)	5	ALA A 310 LEU A 311 GLY A 261 ILE A 171 LEU A 175	None	0.95A	4kt0A-1iy1A: 0.0 4kt0J-1iy1A: 0.0	4kt0A-1iy1A: 17.49 4kt0J-1iy1A: 11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1iy2	ATP-DEPENDENT METALLOPROTEASE FTSH (Thermus thermophilus)	PF00004 (AAA)	5	ALA A 310 LEU A 311 GLY A 261 ILE A 171 LEU A 175	None	1.02A	4kt0A-1iy2A: undetectable 4kt0J-1iy2A: 0.0	4kt0A-1iy2A: 19.32 4kt0J-1iy2A: 12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1mor	GLUCOSAMINE 6-PHOSPHATE SYNTHASE (Escherichia coli)	PF01380 (SIS)	5	SER A 362 LEU A 342 GLY A 369 ILE A 433 LEU A 437	None	1.05A	4kt0A-1morA: undetectable 4kt0J-1morA: undetectable	4kt0A-1morA: 18.92 4kt0J-1morA: 8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1mt0	HEMOLYSIN SECRETION ATP-BINDING PROTEIN (Escherichia coli)	PF00005 (ABC_tran)	5	MET A 648 GLY A 583 ALA A 617 LEU A 620 LEU A 533	None	1.04A	4kt0A-1mt0A: undetectable 4kt0J-1mt0A: 0.0	4kt0A-1mt0A: 14.78 4kt0J-1mt0A: 9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1r8w	GLYCEROL DEHYDRATASE (Clostridium butyricum)	PF01228 (Gly_radical) PF02901 (PFL-like)	5	SER A 661 GLY A 653 ARG A 455 LEU A 651 GLY A 649	None	0.95A	4kt0A-1r8wA: 0.0 4kt0J-1r8wA: undetectable	4kt0A-1r8wA: 21.64 4kt0J-1r8wA: 4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1t3q	QUINOLINE 2-OXIDOREDUCTASE MEDIUM SUBUNIT QUINOLINE 2-OXIDOREDUCTASE SMALL SUBUNIT (Pseudomonas putida)	PF00111 (Fer2) PF00941 (FAD_binding_5) PF01799 (Fer2_2) PF03450 (CO_deh_flav_C)	5	SER A 138 GLY A 139 ALA C 104 ILE C  62 LEU C  69	None	1.08A	4kt0A-1t3qA: undetectable 4kt0J-1t3qA: undetectable	4kt0A-1t3qA: 12.08 4kt0J-1t3qA: 15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1tqy	ACTINORHODIN POLYKETIDE PUTATIVE BETA-KETOACYL SYNTHASE 1 ACTINORHODIN POLYKETIDE PUTATIVE BETA-KETOACYL SYNTHASE 2 (Streptomyces coelicolor)	PF00109 (ketoacyl-synt) PF02801 (Ketoacyl-synt_C)	5	SER B 184 GLY B 185 LEU B 157 ILE A 356 LEU A 414	None	1.11A	4kt0A-1tqyB: undetectable 4kt0J-1tqyB: undetectable	4kt0A-1tqyB: 20.21 4kt0J-1tqyB: 6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1v43	SUGAR-BINDING TRANSPORT ATP-BINDING PROTEIN (Pyrococcus horikoshii)	PF00005 (ABC_tran) PF08402 (TOBE_2)	5	PHE A 331 GLY A 262 ARG A 263 GLY A 332 LEU A 321	None	0.99A	4kt0A-1v43A: undetectable 4kt0J-1v43A: undetectable	4kt0A-1v43A: 19.55 4kt0J-1v43A: 8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1vb3	THREONINE SYNTHASE (Escherichia coli)	PF00291 (PALP) PF14821 (Thr_synth_N)	5	SER A 134 GLY A 135 ALA A 105 ILE A  58 LEU A 262	KPA  A 500 (-3.1A) KPA  A 500 ( 4.2A) None None None	1.00A	4kt0A-1vb3A: undetectable 4kt0J-1vb3A: undetectable	4kt0A-1vb3A: 20.26 4kt0J-1vb3A: 8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wue	MANDELATE RACEMASE/MUCONATE LACTONIZING ENZYME FAMILY PROTEIN (Enterococcus faecalis)	PF02746 (MR_MLE_N) PF13378 (MR_MLE_C)	5	GLY A1168 ARG A1166 ALA A1193 ILE A1260 LEU A1285	None	1.13A	4kt0A-1wueA: undetectable 4kt0J-1wueA: undetectable	4kt0A-1wueA: 18.44 4kt0J-1wueA: 6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wuu	GALACTOKINASE (Homo sapiens)	PF00288 (GHMP_kinases_N) PF08544 (GHMP_kinases_C) PF10509 (GalKase_gal_bdg)	5	GLY A 193 ALA A 383 LEU A  57 GLY A  36 ILE A 368	None	1.07A	4kt0A-1wuuA: undetectable 4kt0J-1wuuA: undetectable	4kt0A-1wuuA: 20.84 4kt0J-1wuuA: 8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1zr5	H2AFY PROTEIN (Homo sapiens)	PF01661 (Macro)	5	GLY A 235 ALA A 206 GLY A 263 ILE A 328 LEU A 288	None	0.87A	4kt0A-1zr5A: undetectable 4kt0J-1zr5A: undetectable	4kt0A-1zr5A: 14.88 4kt0J-1zr5A: 11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2fym	ENOLASE (Escherichia coli)	PF00113 (Enolase_C) PF03952 (Enolase_N)	5	MET A  93 GLY A 106 ALA A  36 LEU A 111 GLY A 346	None	1.12A	4kt0A-2fymA: undetectable 4kt0J-2fymA: undetectable	4kt0A-2fymA: 21.20 4kt0J-2fymA: 7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2gj4	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM (Oryctolagus cuniculus)	PF00343 (Phosphorylase)	5	GLY A 135 ARG A 138 ALA A 141 GLY A 132 LEU A 198	PLR  A 940 ( 3.8A) None None None None	1.06A	4kt0A-2gj4A: undetectable 4kt0J-2gj4A: undetectable	4kt0A-2gj4A: 22.56 4kt0J-2gj4A: 4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ho5	OXIDOREDUCTASE, GFO/IDH/MOCA FAMILY (Streptococcus pneumoniae)	PF01408 (GFO_IDH_MocA)	5	GLY A 211 ALA A 148 GLY A 179 ILE A 270 LEU A 268	None	1.13A	4kt0A-2ho5A: undetectable 4kt0J-2ho5A: undetectable	4kt0A-2ho5A: 18.81 4kt0J-2ho5A: 12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2j6h	GLUCOSAMINE-FRUCTOSE -6-PHOSPHATE AMINOTRANSFERASE (Escherichia coli)	PF01380 (SIS) PF13522 (GATase_6)	5	SER A 362 LEU A 342 GLY A 369 ILE A 433 LEU A 437	None	1.02A	4kt0A-2j6hA: undetectable 4kt0J-2j6hA: undetectable	4kt0A-2j6hA: 21.81 4kt0J-2j6hA: 7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2j7n	RNA-DEPENDENT RNA POLYMERASE (Neurospora crassa)	PF05183 (RdRP)	5	GLY A 712 ALA A 924 GLY A 710 ILE A 971 LEU A 798	None	1.07A	4kt0A-2j7nA: undetectable 4kt0J-2j7nA: undetectable	4kt0A-2j7nA: 21.15 4kt0J-2j7nA: 4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2qpq	PROTEIN BUG27 (Bordetella pertussis)	PF03401 (TctC)	5	SER A 112 ALA A 123 LEU A 120 ILE A 296 LEU A 298	None	1.09A	4kt0A-2qpqA: undetectable 4kt0J-2qpqA: undetectable	4kt0A-2qpqA: 16.95 4kt0J-2qpqA: 6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2v5i	SALMONELLA TYPHIMURIUM DB7155 BACTERIOPHAGE DET7 TAILSPIKE (unidentified phage)	PF09251 (PhageP22-tail)	5	GLY A 656 TRP A 635 ALA A 634 LEU A 625 GLY A 627	None	1.09A	4kt0A-2v5iA: undetectable 4kt0J-2v5iA: undetectable	4kt0A-2v5iA: 22.37 4kt0J-2v5iA: 5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2w2j	CARBONIC ANHYDRASE-RELATED PROTEIN (Homo sapiens)	PF00194 (Carb_anhydrase)	5	GLY A 107 LEU A 104 GLY A 101 ILE A  52 LEU A 280	None	1.12A	4kt0A-2w2jA: undetectable 4kt0J-2w2jA: undetectable	4kt0A-2w2jA: 18.03 4kt0J-2w2jA: 9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2x05	EXO-BETA-D-GLUCOSAMI NIDASE (Amycolatopsis orientalis)	PF00703 (Glyco_hydro_2) PF02837 (Glyco_hydro_2_N)	5	SER A 756 GLY A 757 LEU A 700 GLY A 699 LEU A 356	None	1.12A	4kt0A-2x05A: undetectable 4kt0J-2x05A: undetectable	4kt0A-2x05A: 21.42 4kt0J-2x05A: 2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2xly	CLOQ (Streptomyces roseochromogenus)	PF11468 (PTase_Orf2)	5	MET A 210 GLY A 301 GLY A 304 ILE A 134 LEU A 135	None	1.13A	4kt0A-2xlyA: undetectable 4kt0J-2xlyA: undetectable	4kt0A-2xlyA: 19.36 4kt0J-2xlyA: 11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ya1	PUTATIVE ALKALINE AMYLOPULLULANASE (Streptococcus pneumoniae)	PF00128 (Alpha-amylase) PF02922 (CBM_48) PF03714 (PUD)	5	PHE A 837 GLY A 808 LEU A 805 ILE A 700 LEU A 622	None	1.12A	4kt0A-2ya1A: undetectable 4kt0J-2ya1A: undetectable	4kt0A-2ya1A: 21.26 4kt0J-2ya1A: 3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2yut	PUTATIVE SHORT-CHAIN OXIDOREDUCTASE (Thermus thermophilus)	PF00106 (adh_short)	5	GLY A  10 ARG A  31 ALA A  34 LEU A  35 GLY A  29	NAP  A 500 (-3.2A) NAP  A 500 (-4.8A) None None NAP  A 500 ( 4.1A)	1.08A	4kt0A-2yutA: undetectable 4kt0J-2yutA: undetectable	4kt0A-2yutA: 14.38 4kt0J-2yutA: 11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2yxx	DIAMINOPIMELATE DECARBOXYLASE (Thermotoga maritima)	PF00278 (Orn_DAP_Arg_deC) PF02784 (Orn_Arg_deC_N)	5	GLY A 205 ALA A 200 GLY A 175 ILE A 184 LEU A 224	None	1.11A	4kt0A-2yxxA: undetectable 4kt0J-2yxxA: undetectable	4kt0A-2yxxA: 18.75 4kt0J-2yxxA: 8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2z8z	LIPASE (Pseudomonas sp. MIS38)	PF00353 (HemolysinCabind)	5	GLY A 496 ALA A 531 GLY A 511 ILE A 614 LEU A 609	CA  A 623 (-4.4A) None CA  A 623 (-4.2A) None None	0.94A	4kt0A-2z8zA: undetectable 4kt0J-2z8zA: undetectable	4kt0A-2z8zA: 23.45 4kt0J-2z8zA: 5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zbz	CYTOCHROME P450-SU1 (Streptomyces griseolus)	PF00067 (p450)	5	GLY A 217 ALA A 238 LEU A 163 GLY A 164 LEU A 285	None	1.13A	4kt0A-2zbzA: undetectable 4kt0J-2zbzA: undetectable	4kt0A-2zbzA: 20.92 4kt0J-2zbzA: 7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zds	PUTATIVE DNA-BINDING PROTEIN (Streptomyces coelicolor)	PF01261 (AP_endonuc_2) PF07582 (AP_endonuc_2_N)	5	PHE A 204 GLY A 199 LEU A 165 ILE A  95 LEU A  91	None	1.13A	4kt0A-2zdsA: undetectable 4kt0J-2zdsA: undetectable	4kt0A-2zdsA: 20.28 4kt0J-2zdsA: 7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3act	CELLOBIOSE PHOSPHORYLASE (Cellulomonas gilvus)	PF06165 (Glyco_transf_36) PF17167 (Glyco_hydro_36)	5	PHE A 664 GLY A 661 ALA A 715 ILE A  25 LEU A  36	BGC  A2901 (-4.7A) None None None None	1.05A	4kt0A-3actA: 2.4 4kt0J-3actA: undetectable	4kt0A-3actA: 21.08 4kt0J-3actA: 4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ahi	XYLULOSE 5-PHOSPHATE/FRUCTOSE 6-PHOSPHATE PHOSPHOKETOLASE (Bifidobacterium breve)	PF03894 (XFP) PF09363 (XFP_C) PF09364 (XFP_N)	5	GLY A 181 ALA A 160 GLY A  96 ILE A 598 LEU A 562	HTL  A 827 (-3.3A) None None None None	0.98A	4kt0A-3ahiA: undetectable 4kt0J-3ahiA: undetectable	4kt0A-3ahiA: 21.94 4kt0J-3ahiA: 4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ai7	XYLULOSE-5-PHOSPHATE /FRUCTOSE-6-PHOSPHAT E PHOSPHOKETOLASE (Bifidobacterium longum)	PF03894 (XFP) PF09363 (XFP_C) PF09364 (XFP_N)	5	GLY A 181 ALA A 160 GLY A  96 ILE A 598 LEU A 562	TPP  A 900 (-3.2A) None None None None	0.95A	4kt0A-3ai7A: undetectable 4kt0J-3ai7A: undetectable	4kt0A-3ai7A: 21.06 4kt0J-3ai7A: 3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3g9k	CAPSULE BIOSYNTHESIS PROTEIN CAPD (Bacillus anthracis)	no annotation	5	GLY S 424 ALA S 515 GLY S 426 ILE S 471 LEU S 473	None	1.09A	4kt0A-3g9kS: undetectable 4kt0J-3g9kS: undetectable	4kt0A-3g9kS: 11.98 4kt0J-3g9kS: 10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3gxo	MMCR (Streptomyces lavendulae)	PF00891 (Methyltransf_2)	5	MET A 163 ALA A 171 GLY A 194 ILE A 346 LEU A 323	SAH  A 350 ( 3.7A) None None None None	1.11A	4kt0A-3gxoA: undetectable 4kt0J-3gxoA: undetectable	4kt0A-3gxoA: 19.15 4kt0J-3gxoA: 7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3i83	2-DEHYDROPANTOATE 2-REDUCTASE (Methylococcus capsulatus)	PF02558 (ApbA) PF08546 (ApbA_C)	5	SER A 156 ALA A 163 LEU A 148 GLY A 149 ILE A 138	None	1.06A	4kt0A-3i83A: undetectable 4kt0J-3i83A: undetectable	4kt0A-3i83A: 18.65 4kt0J-3i83A: 8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3il7	3-OXOACYL-[ACYL-CARR IER-PROTEIN] SYNTHASE 3 (Staphylococcus aureus)	PF08541 (ACP_syn_III_C) PF08545 (ACP_syn_III)	5	PHE A 298 GLY A 186 LEU A 190 GLY A 300 ILE A  33	None	1.12A	4kt0A-3il7A: undetectable 4kt0J-3il7A: undetectable	4kt0A-3il7A: 18.93 4kt0J-3il7A: 11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3j4s	FTSZ/TUBULIN-RELATED PROTEIN (Bacillus thuringiensis)	PF00091 (Tubulin)	5	GLY A 140 ALA A  30 GLY A 146 ILE A  23 LEU A 270	GDP  A 900 (-4.2A) None None None None	0.95A	4kt0A-3j4sA: undetectable 4kt0J-3j4sA: undetectable	4kt0A-3j4sA: 20.16 4kt0J-3j4sA: 6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3k7t	6-HYDROXY-L-NICOTINE OXIDASE (Paenarthrobacter nicotinovorans)	PF01593 (Amino_oxidase)	5	ARG A 274 ALA A 268 LEU A 269 ILE A 422 LEU A  20	None	0.94A	4kt0A-3k7tA: undetectable 4kt0J-3k7tA: undetectable	4kt0A-3k7tA: 18.73 4kt0J-3k7tA: 7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3kg9	CURK (Lyngbya majuscula)	PF14765 (PS-DH)	5	SER A 983 GLY A 967 ALA A1015 ILE A1222 LEU A1175	None	1.09A	4kt0A-3kg9A: undetectable 4kt0J-3kg9A: undetectable	4kt0A-3kg9A: 18.50 4kt0J-3kg9A: 8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lmm	UNCHARACTERIZED PROTEIN (Corynebacterium diphtheriae)	PF04326 (AlbA_2) PF13749 (HATPase_c_4)	5	GLY A 214 ARG A 161 ALA A 365 LEU A 362 ILE A 320	None None None CL  A 585 ( 3.8A) None	1.08A	4kt0A-3lmmA: undetectable 4kt0J-3lmmA: undetectable	4kt0A-3lmmA: 22.31 4kt0J-3lmmA: 5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3mos	TRANSKETOLASE (Homo sapiens)	PF00456 (Transketolase_N) PF02779 (Transket_pyr) PF02780 (Transketolase_C)	5	MET A 436 PHE A 437 SER A 439 ALA A 404 ILE A 360	None	1.01A	4kt0A-3mosA: undetectable 4kt0J-3mosA: undetectable	4kt0A-3mosA: 21.10 4kt0J-3mosA: 6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3n05	NH(3)-DEPENDENT NAD(+) SYNTHETASE (Streptomyces avermitilis)	PF00795 (CN_hydrolase) PF02540 (NAD_synthase)	5	GLY A 220 ALA A 187 GLY A 229 ILE A 156 LEU A 151	None	1.07A	4kt0A-3n05A: undetectable 4kt0J-3n05A: undetectable	4kt0A-3n05A: 20.93 4kt0J-3n05A: 4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3nd0	SLL0855 PROTEIN (Synechocystis sp. PCC 6803)	PF00654 (Voltage_CLC)	5	GLY A  43 ALA A 182 GLY A 151 ILE A 436 LEU A 268	None	1.11A	4kt0A-3nd0A: undetectable 4kt0J-3nd0A: undetectable	4kt0A-3nd0A: 23.64 4kt0J-3nd0A: 6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ne5	CATION EFFLUX SYSTEM PROTEIN CUSA (Escherichia coli)	PF00873 (ACR_tran)	5	ALA A1013 LEU A 995 GLY A 994 ILE A 883 LEU A 886	None	1.07A	4kt0A-3ne5A: undetectable 4kt0J-3ne5A: undetectable	4kt0A-3ne5A: 22.35 4kt0J-3ne5A: 3.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3o6u	UNCHARACTERIZED PROTEIN CPE2226 (Clostridium perfringens)	PF04205 (FMN_bind)	5	SER A  89 GLY A  90 GLY A  92 ILE A  59 LEU A 133	None	0.99A	4kt0A-3o6uA: undetectable 4kt0J-3o6uA: undetectable	4kt0A-3o6uA: 11.25 4kt0J-3o6uA: 16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3qha	PUTATIVE OXIDOREDUCTASE (Mycobacterium avium)	PF03446 (NAD_binding_2) PF14833 (NAD_binding_11)	5	GLY A  54 ALA A  27 GLY A  36 ILE A 122 LEU A 115	None	1.03A	4kt0A-3qhaA: undetectable 4kt0J-3qhaA: undetectable	4kt0A-3qhaA: 18.41 4kt0J-3qhaA: 10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3qt3	PUTATIVE UNCHARACTERIZED PROTEIN CPE0426 (Clostridium perfringens)	PF06824 (Glyco_hydro_125)	5	PHE A 395 GLY A 347 ALA A 360 GLY A 394 ILE A  23	None	1.13A	4kt0A-3qt3A: undetectable 4kt0J-3qt3A: undetectable	4kt0A-3qt3A: 20.16 4kt0J-3qt3A: 8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	no annotation	5	GLY N 394 LEU N 330 GLY N 327 ILE N 132 LEU N 170	None	1.07A	4kt0A-3rkoN: undetectable 4kt0J-3rkoN: undetectable	4kt0A-3rkoN: 23.62 4kt0J-3rkoN: 6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3s8d	COENZYME A TRANSFERASE (Yersinia pestis)	PF02550 (AcetylCoA_hydro) PF13336 (AcetylCoA_hyd_C)	5	SER A 299 GLY A 174 GLY A 145 ILE A  21 LEU A  55	None	0.93A	4kt0A-3s8dA: undetectable 4kt0J-3s8dA: undetectable	4kt0A-3s8dA: 20.21 4kt0J-3s8dA: 6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3se5	CELL FILAMENTATION PROTEIN FIC-RELATED PROTEIN (Neisseria meningitidis)	PF02661 (Fic)	5	PHE A  26 SER A  28 GLY A  29 ILE A  97 LEU A 157	None	1.09A	4kt0A-3se5A: undetectable 4kt0J-3se5A: undetectable	4kt0A-3se5A: 11.33 4kt0J-3se5A: 13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3sng	NUCLEASE (Solanum lycopersicum)	PF02265 (S1-P1_nuclease)	5	MET A  33 GLY A 279 ARG A 281 GLY A 150 LEU A 171	None	1.10A	4kt0A-3sngA: undetectable 4kt0J-3sngA: undetectable	4kt0A-3sngA: 18.09 4kt0J-3sngA: 10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3tx8	SUCCINYL-DIAMINOPIME LATE DESUCCINYLASE (Corynebacterium glutamicum)	PF01546 (Peptidase_M20) PF07687 (M20_dimer)	5	GLY A 291 ALA A 266 LEU A 179 GLY A 289 ILE A 209	None	1.11A	4kt0A-3tx8A: undetectable 4kt0J-3tx8A: undetectable	4kt0A-3tx8A: 19.53 4kt0J-3tx8A: 9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3wiq	KOJIBIOSE PHOSPHORYLASE (Caldicellulosiruptor saccharolyticus)	PF03632 (Glyco_hydro_65m) PF03633 (Glyco_hydro_65C) PF03636 (Glyco_hydro_65N)	5	GLY A 334 ALA A  26 GLY A  48 ILE A 120 LEU A 110	None	1.01A	4kt0A-3wiqA: undetectable 4kt0J-3wiqA: undetectable	4kt0A-3wiqA: 20.05 4kt0J-3wiqA: 4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ddw	REVERSE GYRASE (Thermotoga maritima)	PF00270 (DEAD) PF01131 (Topoisom_bac) PF01751 (Toprim)	5	GLY A 478 LEU A 480 GLY A 579 ILE A 510 LEU A 498	None	1.00A	4kt0A-4ddwA: undetectable 4kt0J-4ddwA: undetectable	4kt0A-4ddwA: 19.45 4kt0J-4ddwA: 3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4eyz	CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES (Ruminococcus flavefaciens)	no annotation	5	MET A 181 SER A 184 GLY A 185 GLY A 223 LEU A 107	None	1.09A	4kt0A-4eyzA: undetectable 4kt0J-4eyzA: undetectable	4kt0A-4eyzA: 15.33 4kt0J-4eyzA: 9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4f85	GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERAS E (Streptomyces lasaliensis)	PF02353 (CMAS)	5	PHE A 127 GLY A 106 ALA A 175 LEU A 109 LEU A 257	None	1.12A	4kt0A-4f85A: undetectable 4kt0J-4f85A: undetectable	4kt0A-4f85A: 18.47 4kt0J-4f85A: 9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4fzw	2,3-DEHYDROADIPYL-CO A HYDRATASE (Escherichia coli)	PF00378 (ECH_1)	5	MET A 156 GLY A 105 ALA A 111 LEU A 112 GLY A 140	None	1.00A	4kt0A-4fzwA: undetectable 4kt0J-4fzwA: undetectable	4kt0A-4fzwA: 15.95 4kt0J-4fzwA: 9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ga7	LEUKOCYTE ELASTASE INHIBITOR (Homo sapiens)	PF00079 (Serpin)	5	GLY A  48 ARG A  47 LEU A 304 ILE A 132 LEU A 148	None	0.99A	4kt0A-4ga7A: undetectable 4kt0J-4ga7A: undetectable	4kt0A-4ga7A: 19.92 4kt0J-4ga7A: 7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4hhr	ALPHA-DIOXYGENASE (Arabidopsis thaliana)	PF03098 (An_peroxidase)	5	PHE A 112 SER A 110 GLY A 113 ILE A 551 LEU A 451	None	1.07A	4kt0A-4hhrA: undetectable 4kt0J-4hhrA: undetectable	4kt0A-4hhrA: 20.82 4kt0J-4hhrA: 5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4kw7	ARSENIC METHYLTRANSFERASE (Cyanidioschyzon sp. 5508)	PF13847 (Methyltransf_31)	5	SER A  53 ALA A  78 LEU A  82 ILE A 189 LEU A 185	None	1.12A	4kt0A-4kw7A: undetectable 4kt0J-4kw7A: undetectable	4kt0A-4kw7A: 19.45 4kt0J-4kw7A: 8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4kys	THIAMINE PYRIDINYLASE I (Clostridium botulinum)	PF01547 (SBP_bac_1)	5	GLY A 238 LEU A 185 GLY A 184 ILE A 372 LEU A 369	None	1.02A	4kt0A-4kysA: undetectable 4kt0J-4kysA: undetectable	4kt0A-4kysA: 18.64 4kt0J-4kysA: 8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4n1y	ESTROGEN RECEPTOR (Crassostrea gigas)	PF00104 (Hormone_recep)	5	MET A 407 SER A 410 ALA A 255 LEU A 256 LEU A 465	None	1.06A	4kt0A-4n1yA: undetectable 4kt0J-4n1yA: undetectable	4kt0A-4n1yA: 14.30 4kt0J-4n1yA: 10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ntd	THIOREDOXIN REDUCTASE (Streptomyces clavuligerus)	PF07992 (Pyr_redox_2)	5	SER A 286 GLY A 274 LEU A 119 GLY A 118 LEU A 208	FAD  A 402 (-3.4A) FAD  A 402 (-3.3A) None FAD  A 402 ( 3.7A) None	0.99A	4kt0A-4ntdA: undetectable 4kt0J-4ntdA: undetectable	4kt0A-4ntdA: 18.36 4kt0J-4ntdA: 15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4pj3	INTRON-BINDING PROTEIN AQUARIUS (Homo sapiens)	PF13086 (AAA_11) PF13087 (AAA_12) PF16399 (Aquarius_N)	5	ARG A 194 TRP A 197 LEU A 193 ILE A 313 LEU A 460	None	1.04A	4kt0A-4pj3A: undetectable 4kt0J-4pj3A: undetectable	4kt0A-4pj3A: 17.92 4kt0J-4pj3A: 2.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4rku	PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 (Pisum sativum)	PF00223 (PsaA_PsaB)	9	MET A 691 PHE A 692 SER A 695 GLY A 696 ARG A 697 TRP A 700 ALA A 724 LEU A 725 GLY A 730	CLA  A9013 ( 3.6A) PQN  A5001 (-3.6A) PQN  A5001 (-3.5A) PQN  A5001 ( 4.1A) None PQN  A5001 ( 3.4A) PQN  A5001 (-3.4A) PQN  A5001 ( 3.7A) PQN  A5001 ( 4.0A)	0.27A	4kt0A-4rkuA: 45.6 4kt0J-4rkuA: undetectable	4kt0A-4rkuA: 81.00 4kt0J-4rkuA: 6.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4rku	PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Pisum sativum)	PF00223 (PsaA_PsaB)	7	MET B 662 PHE B 663 SER B 666 ARG B 668 TRP B 671 ALA B 699 LEU B 700	CLA  B9023 ( 3.3A) PQN  B5002 ( 4.3A) PQN  B5002 (-3.2A) None PQN  B5002 ( 3.3A) PQN  B5002 (-3.2A) PQN  B5002 (-3.7A)	0.54A	4kt0A-4rkuB: 34.9 4kt0J-4rkuB: undetectable	4kt0A-4rkuB: 42.75 4kt0J-4rkuB: 4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4uie	SURFACE LAYER PROTEIN (Geobacillus stearothermophilus)	no annotation	5	GLY A 780 ALA A 784 LEU A 783 GLY A 848 ILE A 869	None	1.11A	4kt0A-4uieA: undetectable 4kt0J-4uieA: undetectable	4kt0A-4uieA: 18.87 4kt0J-4uieA: 7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wj3	GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A (Pseudomonas aeruginosa)	PF01425 (Amidase)	5	SER A 153 GLY A 151 GLY A 175 ILE A 259 LEU A 257	None	0.83A	4kt0A-4wj3A: undetectable 4kt0J-4wj3A: undetectable	4kt0A-4wj3A: 22.05 4kt0J-4wj3A: 6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ywo	MERCURIC REDUCTASE (Metallosphaera sedula)	PF02852 (Pyr_redox_dim) PF07992 (Pyr_redox_2)	5	PHE A 108 LEU A 259 GLY A 260 ILE A  35 LEU A  94	None FAD  A 501 (-4.4A) None None None	0.99A	4kt0A-4ywoA: undetectable 4kt0J-4ywoA: undetectable	4kt0A-4ywoA: 20.57 4kt0J-4ywoA: 6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4zhj	MG-CHELATASE SUBUNIT CHLH (Synechocystis sp. PCC 6803)	PF02514 (CobN-Mg_chel) PF11965 (DUF3479)	5	GLY A  19 ARG A  20 ALA A  53 LEU A  52 ILE A 112	None	0.94A	4kt0A-4zhjA: undetectable 4kt0J-4zhjA: undetectable	4kt0A-4zhjA: 20.12 4kt0J-4zhjA: 2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5aor	DOSAGE COMPENSATION REGULATOR (Drosophila melanogaster)	PF00270 (DEAD) PF00271 (Helicase_C) PF04408 (HA2) PF07717 (OB_NTP_bind)	5	PHE A 475 GLY A 462 ALA A 481 ILE A 326 LEU A 812	None	1.08A	4kt0A-5aorA: undetectable 4kt0J-5aorA: undetectable	4kt0A-5aorA: 19.22 4kt0J-5aorA: 3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5bpv	POLYMERASE COFACTOR VP35 (Zaire ebolavirus)	PF02097 (Filo_VP35)	5	PHE A 328 ARG A 312 GLY A 337 ILE A 259 LEU A 256	None	1.00A	4kt0A-5bpvA: undetectable 4kt0J-5bpvA: undetectable	4kt0A-5bpvA: 10.97 4kt0J-5bpvA: 11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	PF13458 (Peripla_BP_6)	5	GLY A 392 ARG A 391 LEU A 390 GLY A 389 LEU A 581	None	1.08A	4kt0A-5ereA: undetectable 4kt0J-5ereA: undetectable	4kt0A-5ereA: 22.61 4kt0J-5ereA: 6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ez3	ACYL-COA DEHYDROGENASE (Brucella melitensis)	PF00441 (Acyl-CoA_dh_1) PF02770 (Acyl-CoA_dh_M)	5	GLY A 321 ARG A 319 GLY A 316 ILE A 462 LEU A 477	None	1.12A	4kt0A-5ez3A: undetectable 4kt0J-5ez3A: undetectable	4kt0A-5ez3A: 22.36 4kt0J-5ez3A: 4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ftx	SURFACE LAYER PROTEIN (Geobacillus stearothermophilus)	no annotation	5	GLY A 780 ALA A 784 LEU A 783 GLY A 848 ILE A 869	None	1.04A	4kt0A-5ftxA: undetectable 4kt0J-5ftxA: undetectable	4kt0A-5ftxA: 23.35 4kt0J-5ftxA: 3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5h3h	ABHYDROLASE DOMAIN-CONTAINING PROTEIN (Exiguobacterium antarcticum)	PF00561 (Abhydrolase_1) PF08386 (Abhydrolase_4)	5	MET A  36 PHE A  37 LEU A 262 ILE A 235 LEU A 205	None	1.09A	4kt0A-5h3hA: undetectable 4kt0J-5h3hA: undetectable	4kt0A-5h3hA: 15.92 4kt0J-5h3hA: 15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ip7	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Saccharomyces cerevisiae)	PF01000 (RNA_pol_A_bac) PF01193 (RNA_pol_L)	5	SER C 109 LEU C 147 GLY C 105 ILE C  46 LEU C  72	None	0.97A	4kt0A-5ip7C: undetectable 4kt0J-5ip7C: undetectable	4kt0A-5ip7C: 16.11 4kt0J-5ip7C: 9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5jjq	AMP-DEPENDENT SYNTHETASE AND LIGASE (Streptomyces sp. ML694-90F3)	PF00501 (AMP-binding) PF13193 (AMP-binding_C)	5	PHE A 191 SER A 374 ALA A 343 GLY A 194 LEU A 301	None None CL  A 602 (-4.0A) None None	0.96A	4kt0A-5jjqA: undetectable 4kt0J-5jjqA: undetectable	4kt0A-5jjqA: 23.00 4kt0J-5jjqA: 8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5kku	POLYKETIDE SYNTHASE TYPE I (Bacillus amyloliquefaciens)	PF14765 (PS-DH)	5	SER A 205 GLY A 204 LEU A 279 ILE A  91 LEU A  76	None	1.01A	4kt0A-5kkuA: undetectable 4kt0J-5kkuA: undetectable	4kt0A-5kkuA: 16.93 4kt0J-5kkuA: 9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5lcw	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 (Homo sapiens)	PF12859 (ANAPC1)	5	GLY A1083 ALA A1142 LEU A1145 ILE A1193 LEU A1227	None	1.07A	4kt0A-5lcwA: undetectable 4kt0J-5lcwA: undetectable	4kt0A-5lcwA: 17.21 4kt0J-5lcwA: 2.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5m86	TA1207 (Thermoplasma acidophilum)	no annotation	5	PHE A  13 GLY A 159 GLY A  11 ILE A 227 LEU A 228	None	1.08A	4kt0A-5m86A: undetectable 4kt0J-5m86A: undetectable	4kt0A-5m86A: 17.68 4kt0J-5m86A: 9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5mlg	RENIN (Rattus norvegicus)	no annotation	5	PHE A  40 SER A 128 GLY A 129 ILE A 243 LEU A 313	None	1.01A	4kt0A-5mlgA: undetectable 4kt0J-5mlgA: undetectable	4kt0A-5mlgA: 7.46 4kt0J-5mlgA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5oaf	RUVB-LIKE 1 (Homo sapiens)	no annotation	5	GLY A  23 ALA A  78 LEU A  79 ILE A 350 LEU A 354	None ADP  A 501 (-3.6A) None None None	1.03A	4kt0A-5oafA: undetectable 4kt0J-5oafA: undetectable	4kt0A-5oafA: 7.79 4kt0J-5oafA: 22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5oy0	PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 (Synechocystis sp. PCC 6803)	no annotation	9	MET 1 684 PHE 1 685 SER 1 688 GLY 1 689 ARG 1 690 TRP 1 693 ALA 1 717 LEU 1 718 GLY 1 723	CLA  1 802 ( 3.2A) PQN  1 842 (-3.8A) PQN  1 842 (-3.4A) PQN  1 842 ( 4.3A) None PQN  1 842 ( 3.3A) PQN  1 842 (-3.2A) PQN  1 842 ( 3.6A) PQN  1 842 ( 3.9A)	0.40A	4kt0A-5oy01: 46.6 4kt0J-5oy01: undetectable	4kt0A-5oy01: 100.00 4kt0J-5oy01: 17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5oy0	PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Synechocystis sp. PCC 6803)	no annotation	7	MET b 659 PHE b 660 SER b 663 ARG b 665 TRP b 668 ALA b 696 LEU b 697	CLA  b1807 ( 3.2A) PQN  b1844 ( 4.2A) PQN  b1844 (-3.7A) None PQN  b1844 ( 3.4A) PQN  b1844 (-3.2A) PQN  b1844 ( 3.8A)	0.61A	4kt0A-5oy0b: 34.4 4kt0J-5oy0b: undetectable	4kt0A-5oy0b: 7.36 4kt0J-5oy0b: 16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5v8k	P800 REACTION CENTER CORE PROTEIN (Heliobacterium modesticaldum)	PF00223 (PsaA_PsaB)	5	SER A 545 ARG A 551 ALA A 580 LEU A 581 GLY A 586	AOH  A1003 (-4.3A) None AOH  A1003 ( 4.9A) None None	1.01A	4kt0A-5v8kA: 23.0 4kt0J-5v8kA: 1.2	4kt0A-5v8kA: 25.70 4kt0J-5v8kA: 10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5w81	CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (Danio rerio)	PF00005 (ABC_tran) PF00664 (ABC_membrane) PF14396 (CFTR_R)	5	GLY A  27 LEU A1048 GLY A1045 ILE A 155 LEU A  49	None	1.09A	4kt0A-5w81A: 2.0 4kt0J-5w81A: undetectable	4kt0A-5w81A: 19.17 4kt0J-5w81A: 3.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6b4o	GLUTATHIONE REDUCTASE (Enterococcus faecalis)	no annotation	5	PHE A 116 LEU A 269 GLY A 270 ILE A  37 LEU A 102	None	1.05A	4kt0A-6b4oA: undetectable 4kt0J-6b4oA: undetectable	4kt0A-6b4oA: 20.87 4kt0J-6b4oA: 6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6cfw	MONOVALENT CATION/H+ ANTIPORTER SUBUNIT B MONOVALENT CATION/H+ ANTIPORTER SUBUNIT C MONOVALENT CATION/H+ ANTIPORTER SUBUNIT D (Pyrococcus furiosus)	no annotation	5	PHE F 117 LEU F 118 GLY F 116 ILE G  74 LEU H 194	None	1.08A	4kt0A-6cfwF: undetectable 4kt0J-6cfwF: undetectable	4kt0A-6cfwF: 7.33 4kt0J-6cfwF: 17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6d0p	PIRIN FAMILY PROTEIN (Acinetobacter baumannii)	no annotation	5	PHE A 120 GLY A 118 GLY A  75 ILE A 286 LEU A 104	None	1.12A	4kt0A-6d0pA: undetectable 4kt0J-6d0pA: undetectable	4kt0A-6d0pA: 7.77 4kt0J-6d0pA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	no annotation	5	PHE A 797 GLY A 842 GLY A 795 ILE A 773 LEU A 774	None SAH  A1102 ( 4.9A) None None None	1.06A	4kt0A-6d6yA: 2.2 4kt0J-6d6yA: undetectable	4kt0A-6d6yA: 7.88 4kt0J-6d6yA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6fg8	PROBABLE INACTIVE RECEPTOR KINASE AT1G27190 (Arabidopsis thaliana)	no annotation	5	GLY B 193 ALA B 177 LEU B 176 ILE B  88 LEU B  92	None	1.03A	4kt0A-6fg8B: undetectable 4kt0J-6fg8B: undetectable	4kt0A-6fg8B: 7.32 4kt0J-6fg8B: 17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6fg8	PROBABLE INACTIVE RECEPTOR KINASE AT1G27190 (Arabidopsis thaliana)	no annotation	5	GLY B 194 ALA B 177 LEU B 176 ILE B  88 LEU B  92	None	1.00A	4kt0A-6fg8B: undetectable 4kt0J-6fg8B: undetectable	4kt0A-6fg8B: 7.32 4kt0J-6fg8B: 17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6fn1	HUMAN-MOUSE CHIMERIC ABCB1 (ABCBHM) (Homo sapiens)	no annotation	5	SER A 830 GLY A 829 LEU A 783 GLY A 780 LEU A 257	None	1.14A	4kt0A-6fn1A: 3.4 4kt0J-6fn1A: 1.5	4kt0A-6fn1A: 8.85 4kt0J-6fn1A: 23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6fos	PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 (Cyanidioschyzon merolae)	no annotation	8	MET A 681 PHE A 682 SER A 685 GLY A 686 ARG A 687 TRP A 690 ALA A 714 LEU A 715	PQN  A2001 ( 3.3A) PQN  A2001 (-4.3A) PQN  A2001 (-4.4A) PQN  A2001 ( 3.9A) None PQN  A2001 ( 3.2A) PQN  A2001 (-3.2A) PQN  A2001 (-3.7A)	0.88A	4kt0A-6fosA: 46.8 4kt0J-6fosA: 1.4	4kt0A-6fosA: 69.23 4kt0J-6fosA: 17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6fos	PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX (Cyanidioschyzon merolae)	no annotation	9	MET A 681 PHE A 682 GLY A 686 ARG A 687 TRP A 690 ALA A 714 LEU A 715 GLY A 720 LEU J  18	PQN  A2001 ( 3.3A) PQN  A2001 (-4.3A) PQN  A2001 ( 3.9A) None PQN  A2001 ( 3.2A) PQN  A2001 (-3.2A) PQN  A2001 (-3.7A) None None	0.82A	4kt0A-6fosA: 46.8 4kt0J-6fosA: 1.4	4kt0A-6fosA: 69.23 4kt0J-6fosA: 17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6fos	PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Cyanidioschyzon merolae)	no annotation	7	MET B 660 PHE B 661 SER B 664 ARG B 666 TRP B 669 ALA B 697 LEU B 698	PQN  B2002 ( 3.2A) PQN  B2002 ( 4.3A) CLA  B1023 (-4.5A) None PQN  B2002 (-3.3A) PQN  B2002 (-3.1A) PQN  B2002 (-3.6A)	0.89A	4kt0A-6fosB: 27.3 4kt0J-6fosB: undetectable	4kt0A-6fosB: 19.42 4kt0J-6fosB: 14.81