SIMILAR PATTERNS OF AMINO ACIDS FOR 4KS8_A_B49A701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 428
VAL A 458
GLY A 480
LEU A 528
SER A 538
ASP A 539
 None
 0.84A 4ks8A-1k2pA:
20.8		 4ks8A-1k2pA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ILE A 201
ALA A 220
VAL A 249
GLY A 272
LEU A 321
SER A 331
 None
 0.74A 4ks8A-1k9aA:
26.8		 4ks8A-1k9aA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ILE A 201
ALA A 220
VAL A 249
LEU A 321
SER A 331
ASP A 332
 None
 1.01A 4ks8A-1k9aA:
26.8		 4ks8A-1k9aA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 369
ALA A 389
VAL A 419
GLY A 441
LEU A 489
SER A 499
ASP A 500
 None
 0.70A 4ks8A-1snxA:
24.2		 4ks8A-1snxA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 369
ALA A 389
VAL A 419
PHE A 437
GLY A 441
LEU A 489
SER A 499
 None
 0.60A 4ks8A-1snxA:
24.2		 4ks8A-1snxA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 367
VAL A 399
MET A 414
GLY A 418
LEU A 468
SER A 478
 STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
STU  A 100 ( 4.7A)
STU  A 100 (-4.5A)
STU  A 100 (-3.1A)
 1.28A 4ks8A-1u59A:
26.3		 4ks8A-1u59A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 367
VAL A 399
MET A 414
GLY A 419
LEU A 468
SER A 478
 STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
None
STU  A 100 (-4.5A)
STU  A 100 (-3.1A)
 1.04A 4ks8A-1u59A:
26.3		 4ks8A-1u59A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 367
VAL A 399
MET A 414
GLY A 420
LEU A 468
SER A 478
 STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.1A)
 0.67A 4ks8A-1u59A:
26.3		 4ks8A-1u59A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ILE A  10
ALA A  30
VAL A  63
LEU A  82
LEU A 132
ASP A 143
 None
 0.72A 4ks8A-1v0bA:
11.8		 4ks8A-1v0bA:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		6 ILE A  18
ALA A  39
LEU A  88
GLY A  89
LEU A 138
ASP A 154
 CKI  A 300 (-4.1A)
CKI  A 300 (-3.6A)
CKI  A 300 (-4.0A)
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
 1.36A 4ks8A-2csnA:
24.5		 4ks8A-2csnA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		6 ILE A  18
ALA A  39
VAL A 153
LEU A  88
GLY A  89
LEU A 138
 CKI  A 300 (-4.1A)
CKI  A 300 (-3.6A)
CKI  A 300 (-4.1A)
CKI  A 300 (-4.0A)
None
CKI  A 300 (-4.4A)
 1.30A 4ks8A-2csnA:
24.5		 4ks8A-2csnA:
25.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 455
ALA A 476
VAL A 507
MET A 523
PHE A 525
LEU A 526
 None
 0.72A 4ks8A-2f57A:
40.9		 4ks8A-2f57A:
71.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
VAL A 323
PHE A 340
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.68A 4ks8A-2hckA:
19.7		 4ks8A-2hckA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 635
ALA A 659
PHE A 709
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.59A 4ks8A-2henA:
24.6		 4ks8A-2henA:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 271
VAL A 301
PHE A 318
GLY A 322
LEU A 371
 1BM  A 499 (-3.6A)
None
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.35A 4ks8A-2hk5A:
19.4		 4ks8A-2hk5A:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 269
VAL A 299
PHE A 317
GLY A 321
LEU A 370
 GIN  A 600 (-3.1A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
 0.40A 4ks8A-2hz0A:
25.7		 4ks8A-2hz0A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ILE A 428
ALA A 452
VAL A 484
MET A 499
GLY A 505
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.3A)
None
4ST  A1687 ( 3.9A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.58A 4ks8A-2j0jA:
24.5		 4ks8A-2j0jA:
17.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  10
ALA A  31
VAL A  64
PHE A  82
LEU A  83
ASP A 145
 None
 0.75A 4ks8A-2jgzA:
28.2		 4ks8A-2jgzA:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  10
ALA A  31
VAL A  64
PHE A  82
LEU A  83
LEU A 134
 None
 0.62A 4ks8A-2jgzA:
28.2		 4ks8A-2jgzA:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 428
ALA A 452
VAL A 484
MET A 499
GLY A 505
LEU A 553
 BII  A1687 (-3.8A)
BII  A1687 (-3.5A)
None
BII  A1687 (-4.1A)
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.42A 4ks8A-2jkmA:
24.2		 4ks8A-2jkmA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ALA A 367
VAL A 399
GLY A 420
LEU A 468
SER A 478
ASP A 479
 ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
MG  A 614 ( 3.2A)
 1.06A 4ks8A-2ozoA:
22.8		 4ks8A-2ozoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ALA A 367
VAL A 399
MET A 414
GLY A 418
LEU A 468
SER A 478
 ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
 1.26A 4ks8A-2ozoA:
22.8		 4ks8A-2ozoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ALA A 367
VAL A 399
MET A 414
GLY A 419
LEU A 468
SER A 478
 ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
None
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
 0.98A 4ks8A-2ozoA:
22.8		 4ks8A-2ozoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ALA A 367
VAL A 399
MET A 414
GLY A 420
LEU A 468
SER A 478
 ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
 0.85A 4ks8A-2ozoA:
22.8		 4ks8A-2ozoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		5 ILE B  47
ALA B  67
VAL B  98
GLY B 120
LEU B 171
 None
 0.24A 4ks8A-2qkwB:
25.8		 4ks8A-2qkwB:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  82
ALA A 103
VAL A 137
MET A 153
GLY A 159
LEU A 205
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.1A)
None
ANP  A1480 ( 4.7A)
 0.66A 4ks8A-2v55A:
26.7		 4ks8A-2v55A:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE B  75
VAL B 131
PHE B 149
GLY B 153
LEU B 202
SER B 212
 ANP  B 432 (-4.4A)
None
ANP  B 432 ( 4.9A)
ANP  B 432 ( 4.2A)
ANP  B 432 ( 4.7A)
None
 0.86A 4ks8A-2wtkB:
25.7		 4ks8A-2wtkB:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  47
MET A  95
LEU A  98
GLY A 101
LEU A 147
 J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.6A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.40A 4ks8A-2xikA:
38.7		 4ks8A-2xikA:
38.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  30
ALA A  51
GLY A 113
LEU A 160
SER A 170
ASP A 171
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
B49  A1294 (-4.2A)
 0.72A 4ks8A-2y7jA:
30.6		 4ks8A-2y7jA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  92
VAL A 125
PHE A 143
LEU A 144
GLY A 147
LEU A 194
 STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 (-4.0A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.53A 4ks8A-2z7rA:
26.9		 4ks8A-2z7rA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 273
VAL A 303
PHE A 321
GLY A 325
LEU A 374
 None
 0.33A 4ks8A-2zv7A:
27.0		 4ks8A-2zv7A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  18
ALA A  39
VAL A  75
PHE A  93
GLY A  96
LEU A 148
 3AM  A 338 (-4.5A)
3AM  A 338 (-3.3A)
None
3AM  A 338 ( 4.6A)
None
3AM  A 338 (-4.7A)
 1.14A 4ks8A-3c0iA:
29.9		 4ks8A-3c0iA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 201
ALA A 220
VAL A 249
GLY A 272
LEU A 321
SER A 331
 None
 0.74A 4ks8A-3d7uA:
26.9		 4ks8A-3d7uA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 201
ALA A 220
VAL A 249
LEU A 321
SER A 331
ASP A 332
 None
 1.02A 4ks8A-3d7uA:
26.9		 4ks8A-3d7uA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 639
ALA A 663
VAL A 695
PHE A 713
GLY A 717
LEU A 765
SER A 775
 IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-3.7A)
 0.83A 4ks8A-3dkoA:
23.2		 4ks8A-3dkoA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 150
ALA A 169
MET A 220
PHE A 222
GLY A 226
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.7A)
VIN  A6331 ( 4.8A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
 0.21A 4ks8A-3dtcA:
24.9		 4ks8A-3dtcA:
29.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ILE A  62
ALA A  83
VAL A 116
MET A 132
LEU A 185
ASP A 196
 None
 1.01A 4ks8A-3fe3A:
22.4		 4ks8A-3fe3A:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 209
ALA A 228
MET A 279
GLY A 285
LEU A 340
SER A 350
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
None
 0.87A 4ks8A-3g2fA:
26.7		 4ks8A-3g2fA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ILE A 557
ALA A 576
VAL A 609
LEU A 628
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.5A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.70A 4ks8A-3ppzA:
29.3		 4ks8A-3ppzA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.48A 4ks8A-3wzdA:
23.1		 4ks8A-3wzdA:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 625
ALA A 649
PHE A 699
GLY A 703
LEU A 751
SER A 761
ASP A 762
 None
 0.56A 4ks8A-3zfxA:
26.3		 4ks8A-3zfxA:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.43A 4ks8A-4agdA:
6.6		 4ks8A-4agdA:
27.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A  97
ALA A 121
PHE A 171
GLY A 175
LEU A 223
SER A 233
ASP A 234
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
30K  A1365 (-3.3A)
 0.83A 4ks8A-4aw5A:
24.8		 4ks8A-4aw5A:
32.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  63
VAL A  94
PHE A 112
GLY A 116
LEU A 164
ASP A 175
 XZN  A1317 (-3.5A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 (-3.2A)
 0.57A 4ks8A-4bc6A:
28.5		 4ks8A-4bc6A:
34.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 684
VAL A 721
MET A 737
GLY A 743
LEU A 789
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
 0.34A 4ks8A-4crsA:
28.9		 4ks8A-4crsA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ILE A  17
ALA A  38
VAL A  72
PHE A  90
LEU A 141
SER A 151
ASP A 152
 None
 1.36A 4ks8A-4d28A:
22.5		 4ks8A-4d28A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ILE A 567
ALA A 588
VAL A 620
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.50A 4ks8A-4e93A:
20.8		 4ks8A-4e93A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ILE A 567
ALA A 588
VAL A 620
MET A 636
GLY A 642
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.53A 4ks8A-4e93A:
20.8		 4ks8A-4e93A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 400
VAL A 433
MET A 448
GLY A 454
LEU A 501
SER A 511
ASP A 512
 0SB  A 701 (-3.3A)
None
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
0SB  A 701 (-3.9A)
 0.82A 4ks8A-4f4pA:
26.2		 4ks8A-4f4pA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		10 ILE A 327
ALA A 348
VAL A 379
MET A 395
PHE A 397
LEU A 398
GLY A 401
LEU A 447
SER A 457
ASP A 458
 None
ANP  A1001 (-3.6A)
None
ANP  A1001 (-4.8A)
ANP  A1001 ( 4.6A)
ANP  A1001 (-4.6A)
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
ANP  A1001 (-2.7A)
 0.67A 4ks8A-4fieA:
43.6		 4ks8A-4fieA:
52.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		6 VAL A 379
MET A 395
PHE A 397
LEU A 398
GLY A 400
SER A 457
 None
ANP  A1001 (-4.8A)
ANP  A1001 ( 4.6A)
ANP  A1001 (-4.6A)
None
ANP  A1001 ( 4.4A)
 1.18A 4ks8A-4fieA:
43.6		 4ks8A-4fieA:
52.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ALA A 400
VAL A 433
GLY A 454
LEU A 501
SER A 511
ASP A 512
 ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
MG  A 702 ( 3.1A)
 1.00A 4ks8A-4fl3A:
23.5		 4ks8A-4fl3A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ALA A 400
VAL A 433
MET A 448
GLY A 454
LEU A 501
SER A 511
 ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 3.7A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
 0.79A 4ks8A-4fl3A:
23.5		 4ks8A-4fl3A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  29
ALA A  50
VAL A  84
LEU A 103
GLY A 106
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 (-3.2A)
None
STU  A 401 (-4.3A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.56A 4ks8A-4fr4A:
27.5		 4ks8A-4fr4A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 880
VAL A 911
MET A 929
LEU A 932
GLY A 935
LEU A 983
 IZA  A2001 (-3.4A)
None
IZA  A2001 (-4.4A)
IZA  A2001 (-4.4A)
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
 0.48A 4ks8A-4gl9A:
26.6		 4ks8A-4gl9A:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 853
VAL A 884
MET A 902
LEU A 905
GLY A 908
LEU A 956
 19S  A1201 (-3.3A)
None
19S  A1201 (-3.6A)
19S  A1201 (-4.4A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.37A 4ks8A-4hviA:
20.1		 4ks8A-4hviA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 427
VAL A 453
MET A 469
LEU A 472
GLY A 475
LEU A 522
 T28  A 701 (-3.0A)
None
T28  A 701 (-2.6A)
T28  A 701 (-4.5A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.68A 4ks8A-4idtA:
29.6		 4ks8A-4idtA:
27.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  54
VAL A  83
MET A  99
GLY A 105
LEU A 153
ASP A 164
 GOL  A 404 ( 3.1A)
GOL  A 403 (-4.1A)
GOL  A 403 (-2.7A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
GOL  A 403 (-2.4A)
 0.73A 4ks8A-4lg4A:
30.7		 4ks8A-4lg4A:
36.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 293
VAL A 323
GLY A 344
LEU A 393
ASP A 404
 VGG  A 601 (-3.5A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.27A 4ks8A-4lggA:
23.7		 4ks8A-4lggA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  72
VAL A 104
MET A 126
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 (-3.2A)
None
KSA  A 405 ( 3.7A)
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.40A 4ks8A-4wsqA:
26.1		 4ks8A-4wsqA:
29.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		9 ALA A 348
VAL A 379
MET A 395
PHE A 397
LEU A 398
GLY A 401
LEU A 447
SER A 457
ASP A 458
 ATP  A 601 ( 3.7A)
None
ATP  A 601 (-4.3A)
ATP  A 601 (-4.6A)
ATP  A 601 (-4.3A)
None
None
ATP  A 601 ( 4.6A)
ATP  A 601 ( 2.5A)
 0.68A 4ks8A-4xbrA:
34.2		 4ks8A-4xbrA:
62.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		9 ILE A 327
ALA A 348
VAL A 379
MET A 395
PHE A 397
LEU A 398
LEU A 447
SER A 457
ASP A 458
 None
ATP  A 601 ( 3.7A)
None
ATP  A 601 (-4.3A)
ATP  A 601 (-4.6A)
ATP  A 601 (-4.3A)
None
ATP  A 601 ( 4.6A)
ATP  A 601 ( 2.5A)
 0.72A 4ks8A-4xbrA:
34.2		 4ks8A-4xbrA:
62.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		7 VAL A 379
MET A 395
PHE A 397
LEU A 398
GLY A 400
LEU A 447
SER A 457
 None
ATP  A 601 (-4.3A)
ATP  A 601 (-4.6A)
ATP  A 601 (-4.3A)
None
None
ATP  A 601 ( 4.6A)
 1.21A 4ks8A-4xbrA:
34.2		 4ks8A-4xbrA:
62.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 428
VAL A 458
GLY A 480
LEU A 528
SER A 538
ASP A 539
 None
 0.77A 4ks8A-4xi2A:
24.4		 4ks8A-4xi2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 ALA A 428
VAL A 458
GLY A 480
LEU A 528
SER A 538
ASP A 539
 746  A 702 (-2.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
746  A 702 (-3.7A)
 0.86A 4ks8A-4y93A:
24.7		 4ks8A-4y93A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  10
ALA A  31
VAL A  64
PHE A  82
LEU A  83
LEU A 135
ASP A 146
 None
 0.79A 4ks8A-4yc6A:
24.1		 4ks8A-4yc6A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8f 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF02542
(YgbB) 		6 ILE A 109
ALA A 131
VAL A 148
LEU A  20
GLY A  21
LEU A  40
 None
C5P  A 202 (-3.8A)
None
None
None
None
 1.43A 4ks8A-5b8fA:
undetectable		 4ks8A-5b8fA:
18.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  22
ALA A  44
VAL A  76
MET A  92
GLY A  98
LEU A 145
ASP A 165
 51W  A 401 (-3.9A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.78A 4ks8A-5ci7A:
26.4		 4ks8A-5ci7A:
31.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  52
MET A 105
PHE A 107
GLY A 111
LEU A 160
ASP A 171
 ALA  A  52 (-0.0A)
MET  A 105 (-0.0A)
PHE  A 107 ( 1.3A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 1.03A 4ks8A-5d7aA:
29.9		 4ks8A-5d7aA:
37.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd CASEIN KINASE I
ISOFORM ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE C  23
ALA C  44
MET C  90
LEU C  93
GLY C  94
LEU C 143
 None
 1.27A 4ks8A-5fqdC:
24.5		 4ks8A-5fqdC:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
VAL A  74
MET A  90
PHE A  92
GLY A  96
LEU A 143
 6G2  A 901 (-3.2A)
None
6G2  A 901 (-3.5A)
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.52A 4ks8A-5j5tA:
29.3		 4ks8A-5j5tA:
32.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  22
ALA A  43
VAL A  74
PHE A  92
GLY A  96
LEU A 143
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.48A 4ks8A-5j5tA:
29.3		 4ks8A-5j5tA:
32.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 396
ALA A 417
VAL A 449
MET A 465
GLY A 471
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.46A 4ks8A-5jznA:
26.8		 4ks8A-5jznA:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 276
ALA A 297
VAL A 328
MET A 344
LEU A 347
GLY A 350
LEU A 396
 IPW  A 601 (-4.0A)
IPW  A 601 (-3.5A)
None
IPW  A 601 (-3.5A)
IPW  A 601 (-4.2A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.53A 4ks8A-5kbrA:
36.5		 4ks8A-5kbrA:
48.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  60
VAL A  94
MET A 110
LEU A 113
GLY A 115
LEU A 163
 STU  A 901 (-3.3A)
None
STU  A 901 (-3.7A)
STU  A 901 (-4.1A)
None
STU  A 901 (-4.5A)
 0.94A 4ks8A-5lohA:
22.1		 4ks8A-5lohA:
29.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  41
ALA A  60
VAL A  94
MET A 110
LEU A 113
GLY A 116
LEU A 163
 STU  A 901 (-4.3A)
STU  A 901 (-3.3A)
None
STU  A 901 (-3.7A)
STU  A 901 (-4.1A)
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
 0.73A 4ks8A-5lohA:
22.1		 4ks8A-5lohA:
29.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ILE A 889
ALA A 909
VAL A 940
PHE A 958
GLY A 962
LEU A1016
SER A1026
 None
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 ( 4.7A)
 0.49A 4ks8A-5lpyA:
24.8		 4ks8A-5lpyA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ILE A 889
ALA A 909
VAL A 940
PHE A 958
LEU A1016
SER A1026
ASP A1027
 None
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 ( 4.7A)
ATP  A1200 (-4.1A)
 0.70A 4ks8A-5lpyA:
24.8		 4ks8A-5lpyA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ILE A 889
ALA A 909
VAL A 940
PHE A 958
GLY A 962
LEU A1016
SER A1026
 ADP  A1200 (-4.7A)
ADP  A1200 (-3.5A)
None
ADP  A1200 (-4.1A)
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
ADP  A1200 ( 4.6A)
 0.72A 4ks8A-5lpzA:
24.8		 4ks8A-5lpzA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 889
ALA A 909
VAL A 940
PHE A 958
SER A1026
ASP A1027
 ADP  A1200 (-4.7A)
ADP  A1200 (-3.5A)
None
ADP  A1200 (-4.1A)
ADP  A1200 ( 4.6A)
ADP  A1200 (-3.4A)
 0.97A 4ks8A-5lpzA:
24.8		 4ks8A-5lpzA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 119
VAL A 157
LEU A 180
GLY A 181
LEU A 232
ASP A 541
 W4A  A 716 ( 3.9A)
DMS  A 717 (-4.3A)
W4A  A 716 (-4.3A)
W4A  A 716 (-3.8A)
None
DMS  A 717 (-4.3A)
 0.99A 4ks8A-5myvA:
23.5		 4ks8A-5myvA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 7 ILE A 358
ALA A 379
PHE A 431
LEU A 432
GLY A 435
LEU A 482
SER A 492
 ANP  A 801 (-4.2A)
ANP  A 801 ( 3.9A)
ANP  A 801 ( 4.9A)
ANP  A 801 (-4.7A)
None
ANP  A 801 (-4.8A)
None
 0.87A 4ks8A-5nclA:
2.9		 4ks8A-5nclA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 6 ILE A 358
ALA A 379
PHE A 431
LEU A 432
SER A 492
ASP A 493
 ANP  A 801 (-4.2A)
ANP  A 801 ( 3.9A)
ANP  A 801 ( 4.9A)
ANP  A 801 (-4.7A)
None
None
 1.37A 4ks8A-5nclA:
2.9		 4ks8A-5nclA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 7 ILE A 358
ALA A 379
VAL A 413
MET A 429
PHE A 431
LEU A 432
ASP A 493
 ANP  A 801 (-4.2A)
ANP  A 801 ( 3.9A)
ANP  A 801 ( 4.9A)
ANP  A 801 ( 4.5A)
ANP  A 801 ( 4.9A)
ANP  A 801 (-4.7A)
None
 1.17A 4ks8A-5nclA:
2.9		 4ks8A-5nclA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 8 ILE A 358
ALA A 379
VAL A 413
MET A 429
PHE A 431
LEU A 432
GLY A 435
LEU A 482
 ANP  A 801 (-4.2A)
ANP  A 801 ( 3.9A)
ANP  A 801 ( 4.9A)
ANP  A 801 ( 4.5A)
ANP  A 801 ( 4.9A)
ANP  A 801 (-4.7A)
None
ANP  A 801 (-4.8A)
 0.81A 4ks8A-5nclA:
2.9		 4ks8A-5nclA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 6 VAL A 413
MET A 429
PHE A 431
LEU A 432
GLY A 434
LEU A 482
 ANP  A 801 ( 4.9A)
ANP  A 801 ( 4.5A)
ANP  A 801 ( 4.9A)
ANP  A 801 (-4.7A)
None
ANP  A 801 (-4.8A)
 1.15A 4ks8A-5nclA:
2.9		 4ks8A-5nclA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1

(Arabidopsis
thaliana) 		no annotation 6 ALA A 103
VAL A 134
PHE A 152
GLY A 156
LEU A 209
SER A 219
 None
 0.82A 4ks8A-5tosA:
19.2		 4ks8A-5tosA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  98
ALA A 119
VAL A 153
MET A 169
GLY A 175
LEU A 221
 None
 0.52A 4ks8A-5u7qA:
22.8		 4ks8A-5u7qA:
26.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 6 ALA A 348
VAL A 379
MET A 395
PHE A 397
LEU A 398
GLY A 400
 M77  A 601 ( 3.5A)
None
M77  A 601 ( 2.9A)
M77  A 601 (-4.1A)
M77  A 601 (-4.4A)
None
 1.21A 4ks8A-5vefA:
44.6		 4ks8A-5vefA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 10 ILE A 327
ALA A 348
VAL A 379
MET A 395
PHE A 397
LEU A 398
GLY A 401
LEU A 447
SER A 457
ASP A 458
 M77  A 601 ( 4.8A)
M77  A 601 ( 3.5A)
None
M77  A 601 ( 2.9A)
M77  A 601 (-4.1A)
M77  A 601 (-4.4A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
M77  A 601 (-3.2A)
M77  A 601 ( 3.5A)
 0.53A 4ks8A-5vefA:
44.6		 4ks8A-5vefA:
70.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 150
MET A 190
PHE A 192
GLY A 196
LEU A 243
SER A 253
 9FS  A 501 (-3.4A)
9FS  A 501 (-3.6A)
9FS  A 501 (-4.3A)
9FS  A 501 (-3.6A)
9FS  A 501 (-4.7A)
9FS  A 501 ( 4.3A)
 0.69A 4ks8A-5vo1A:
24.2		 4ks8A-5vo1A:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 7 ALA A 225
VAL A 257
MET A 273
PHE A 275
GLY A 279
LEU A 326
ASP A 339
 None
 0.84A 4ks8A-5xzwA:
21.8		 4ks8A-5xzwA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 8 ILE A 218
ALA A 237
VAL A 272
PHE A 290
LEU A 291
GLY A 294
LEU A 347
ASP A 358
 DL1  A 601 (-4.0A)
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.8A)
DL1  A 601 (-4.3A)
DL1  A 601 (-4.4A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 0.56A 4ks8A-6bfnA:
24.7		 4ks8A-6bfnA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 ILE A 171
ALA A 192
VAL A 249
GLY A 273
LEU A 319
 BI9  A 501 (-4.0A)
BI9  A 501 (-3.3A)
None
BI9  A 501 (-3.3A)
BI9  A 501 (-4.7A)
 0.42A 4ks8A-6bqlA:
29.7		 4ks8A-6bqlA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 ALA A 906
VAL A 938
MET A 956
PHE A 958
LEU A 959
GLY A 962
LEU A1010
 ADP  A1201 (-3.4A)
None
ADP  A1201 (-4.2A)
None
ADP  A1201 (-4.6A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.52A 4ks8A-6c7yA:
27.1		 4ks8A-6c7yA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 ALA A 906
VAL A 938
MET A 956
PHE A 958
LEU A1010
ASP A1021
 ADP  A1201 (-3.4A)
None
ADP  A1201 (-4.2A)
None
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.78A 4ks8A-6c7yA:
27.1		 4ks8A-6c7yA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 6 ILE A 134
ALA A 155
VAL A 212
LEU A 233
GLY A 236
LEU A 282
 H1N  A 501 (-4.3A)
H1N  A 501 (-3.4A)
H1N  A 501 (-4.9A)
H1N  A 501 (-4.6A)
H1N  A 501 (-3.6A)
H1N  A 501 (-4.8A)
 0.34A 4ks8A-6ccfA:
28.4		 4ks8A-6ccfA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 ALA U  42
VAL U  75
MET U  91
PHE U  93
GLY U  97
LEU U 144
 DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.69A 4ks8A-6fdyU:
28.3		 4ks8A-6fdyU:
undetectable