SIMILAR PATTERNS OF AMINO ACIDS FOR 4KRA_C_CPFC401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		5 ARG 1 254
TYR 1 258
ARG 1 104
GLY 1 209
THR 1 211
 None
 1.18A 4kraC-1ev11:
0.0		 4kraC-1ev11:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 ARG A  48
TYR A  46
GLU A  43
GLY A  79
THR A  81
 FAD  A1449 (-4.0A)
None
None
None
FAD  A1449 ( 4.3A)
 1.10A 4kraC-2gqwA:
0.0		 4kraC-2gqwA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyj RHODOPSIN

(Exiguobacterium
sibiricum) 		PF01036
(Bac_rhodopsin) 		5 ARG A  82
TYR A 217
ARG A 213
TYR A  83
GLY A 143
 None
 1.42A 4kraC-4hyjA:
undetectable		 4kraC-4hyjA:
19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kr8 OUTER MEMBRANE
PROTEIN F

(Salmonella
enterica) 		PF00267
(Porin_1) 		7 TYR A  36
ARG A  60
TYR A 112
GLU A 116
GLY A 120
THR A 123
ARG A 130
 None
 0.90A 4kraC-4kr8A:
46.3		 4kraC-4kr8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kr8 OUTER MEMBRANE
PROTEIN F

(Salmonella
enterica) 		PF00267
(Porin_1) 		7 TYR A  36
ARG A  77
TYR A 112
GLU A 116
GLY A 120
THR A 123
ARG A 130
 None
 0.64A 4kraC-4kr8A:
46.3		 4kraC-4kr8A:
100.00