SIMILAR PATTERNS OF AMINO ACIDS FOR 4KOW_A_CFXA204_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g3p | MINOR COAT PROTEIN (Escherichiavirus M13) |
PF05357(Phage_Coat_A) | 5 | PRO A 123ASN A 120SER A 172TYR A 177LEU A 106 | None | 1.04A | 4kowA-1g3pA:undetectable | 4kowA-1g3pA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iyx | ENOLASE (Enterococcushirae) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | GLY A 392ASN A 147MET A 146SER A 366LEU A 337 | None | 1.23A | 4kowA-1iyxA:0.3 | 4kowA-1iyxA:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jny | ELONGATION FACTOR1-ALPHA (Sulfolobussolfataricus) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 5 | PRO A 195GLY A 18ASN A 152PHE A 55LEU A 59 | GDP A 500 (-4.3A)GDP A 500 (-3.2A)GDP A 500 (-3.2A)NoneNone | 1.47A | 4kowA-1jnyA:undetectable | 4kowA-1jnyA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tww | DHPS,DIHYDROPTEROATESYNTHASE (Bacillusanthracis) |
PF00809(Pterin_bind) | 5 | PRO A 212GLY A 249ASN A 207PHE A 252LEU A 21 | None | 1.49A | 4kowA-1twwA:0.2 | 4kowA-1twwA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v0f | ENDO-ALPHA-SIALIDASE (Enterobacteriaphage K1F) |
PF12217(End_beta_propel)PF12218(End_N_terminal)PF12219(End_tail_spike) | 5 | PRO A 372TYR A 324GLY A 346ASN A 326MET A 345 | PRO A 372 ( 1.1A)TYR A 324 ( 1.3A)GLY A 346 ( 0.0A)ASN A 326 ( 0.6A)MET A 345 ( 0.0A) | 1.34A | 4kowA-1v0fA:0.0 | 4kowA-1v0fA:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v7v | CHITOBIOSEPHOSPHORYLASE (Vibrioproteolyticus) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 5 | PRO A 740GLY A 745ASN A 763SER A 308LEU A 313 | None | 1.36A | 4kowA-1v7vA:1.1 | 4kowA-1v7vA:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aeg | HYPOTHETICAL PROTEINAGR_PAT_140 (Agrobacteriumfabrum) |
PF02586(SRAP) | 5 | PHE A 154PRO A 121TYR A 30GLY A 38LEU A 51 | None | 1.46A | 4kowA-2aegA:0.0 | 4kowA-2aegA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fym | ENOLASE (Escherichiacoli) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | GLY A 394ASN A 151MET A 150SER A 368LEU A 339 | None | 1.22A | 4kowA-2fymA:0.0 | 4kowA-2fymA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ge3 | PROBABLEACETYLTRANSFERASE (Agrobacteriumtumefaciens) |
PF00583(Acetyltransf_1) | 5 | ARG A 76GLY A 90MET A 91SER A 125TYR A 137 | NoneNoneACO A1301 (-3.9A)NoneNone | 1.45A | 4kowA-2ge3A:17.4 | 4kowA-2ge3A:24.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jam | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE 1G (Homo sapiens) |
PF00069(Pkinase) | 5 | PHE A 300PRO A 147ASN A 149PHE A 107LEU A 213 | None | 1.44A | 4kowA-2jamA:undetectable | 4kowA-2jamA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jf7 | STRICTOSIDINE-O-BETA-D-GLUCOSIDASE (Rauvolfiaserpentina) |
PF00232(Glyco_hydro_1) | 5 | PHE A 205PRO A 208ASN A 273MET A 342LEU A 246 | None | 1.27A | 4kowA-2jf7A:0.9 | 4kowA-2jf7A:17.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l3d | LYSINE-SPECIFICHISTONE DEMETHYLASE1A (Homo sapiens) |
PF04433(SWIRM) | 5 | PHE A 25GLY A 31PHE A 39ARG A 80LEU A 77 | None | 1.41A | 4kowA-2l3dA:undetectable | 4kowA-2l3dA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vaw | CELL DIVISIONPROTEIN FTSZ (Pseudomonasaeruginosa) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | PHE A 138GLY A 104MET A 105PHE A 136LEU A 169 | NoneGDP A1317 (-3.1A)NoneNoneNone | 1.26A | 4kowA-2vawA:undetectable | 4kowA-2vawA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] LARGE CHAIN (Azospirillumbrasilense) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | GLY A1370ASN A1350SER A 959PHE A 915LEU A 965 | None | 1.30A | 4kowA-2vdcA:undetectable | 4kowA-2vdcA:7.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2q | 6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE (Arthrobactersp. KI72) |
PF01425(Amidase) | 5 | PRO A 427ARG A 176PHE A 308ARG A 306LEU A 309 | None | 1.36A | 4kowA-3a2qA:undetectable | 4kowA-3a2qA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3af5 | PUTATIVEUNCHARACTERIZEDPROTEIN PH1404 (Pyrococcushorikoshii) |
PF07521(RMMBL)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 5 | PHE A 235PRO A 233GLY A 193ASN A 644LEU A 215 | NoneNoneNoneSO4 A 652 (-4.0A)None | 1.10A | 4kowA-3af5A:undetectable | 4kowA-3af5A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bb7 | INTERPAIN A (Prevotellaintermedia) |
PF01640(Peptidase_C10)PF13734(Inhibitor_I69) | 5 | TYR A 332GLY A 75SER A 77PHE A 81TYR A 56 | None | 1.21A | 4kowA-3bb7A:undetectable | 4kowA-3bb7A:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fvb | BACTERIOFERRITIN (Brucellaabortus) |
PF00210(Ferritin) | 5 | PRO A 76ARG A 78GLY A 93PHE A 16TYR A 101 | None | 1.33A | 4kowA-3fvbA:undetectable | 4kowA-3fvbA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdn | R-OXYNITRILE LYASEISOENZYME 1 (Prunus dulcis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | PHE A 342ARG A 194GLY A 112ASN A 110PHE A 330 | HBX A 530 ( 4.7A)NoneFAD A 522 (-3.9A)FAD A 522 (-4.2A)HBX A 530 (-4.0A) | 1.41A | 4kowA-3gdnA:undetectable | 4kowA-3gdnA:14.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kkw | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 5 | ARG A 49TYR A 68GLY A 79ASN A 66TYR A 128 | EDO A 175 ( 3.0A)EDO A 175 (-3.6A)EDO A 175 ( 3.6A)NoneEDO A 176 ( 4.8A) | 1.35A | 4kowA-3kkwA:32.0 | 4kowA-3kkwA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kkw | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 12 | PHE A 27PRO A 31ARG A 49TYR A 68GLY A 79ASN A 80MET A 81SER A 116PHE A 118TYR A 128ARG A 141LEU A 151 | EDO A 171 ( 4.5A)EDO A 175 (-4.3A)EDO A 175 ( 3.0A)EDO A 175 (-3.6A)EDO A 175 ( 3.6A)EDO A 175 ( 4.3A)EDO A 174 ( 4.8A)SO4 A 161 (-4.8A)NoneEDO A 176 ( 4.8A)SO4 A 161 (-3.9A)None | 0.40A | 4kowA-3kkwA:32.0 | 4kowA-3kkwA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kya | PUTATIVE PHOSPHATASE (Bacteroidesthetaiotaomicron) |
PF01833(TIG) | 5 | PHE A 356ARG A 211GLY A 273ASN A 272PHE A 338 | NoneEDO A 1 (-4.6A)NoneEDO A 1 (-3.7A)None | 1.38A | 4kowA-3kyaA:undetectable | 4kowA-3kyaA:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3red | HYDROXYNITRILE LYASE (Prunus mume) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | PHE A 343ARG A 194GLY A 112ASN A 110PHE A 331 | NoneNoneFAD A 773 (-3.9A)FAD A 773 (-4.3A)None | 1.39A | 4kowA-3redA:undetectable | 4kowA-3redA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rh2 | HYPOTHETICALTETR-LIKETRANSCRIPTIONALREGULATOR (Shewanellaamazonensis) |
PF00440(TetR_N)PF13972(TetR) | 5 | TYR A 96GLY A 156MET A 153PHE A 65LEU A 61 | NoneUNL A 301 ( 4.7A)NoneUNL A 301 ( 4.2A)None | 1.33A | 4kowA-3rh2A:undetectable | 4kowA-3rh2A:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wp5 | CDBFV (Neocallimastixpatriciarum) |
PF00457(Glyco_hydro_11) | 5 | ARG A 61TYR A 100GLY A 101PHE A 159ARG A 148 | None | 1.40A | 4kowA-3wp5A:undetectable | 4kowA-3wp5A:16.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zuq | BOTULINUM NEUROTOXINTYPE B (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07952(Toxin_trans) | 5 | PRO A 539GLY A 115ASN A 114TYR A 328LEU A 119 | None | 1.44A | 4kowA-3zuqA:undetectable | 4kowA-3zuqA:10.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a3r | ENOLASE (Bacillussubtilis) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | GLY A 392ASN A 148MET A 147SER A 366LEU A 337 | None | 1.16A | 4kowA-4a3rA:undetectable | 4kowA-4a3rA:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eco | UNCHARACTERIZEDPROTEIN (Bacteroideseggerthii) |
no annotation | 5 | PHE A 664GLY A 618ASN A 639PHE A 643LEU A 626 | None | 1.48A | 4kowA-4ecoA:undetectable | 4kowA-4ecoA:14.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fcg | UNCHARACTERIZEDPROTEIN (Xanthomonaseuvesicatoria) |
PF13855(LRR_8) | 5 | GLY A 237ASN A 259MET A 239PHE A 218TYR A 161 | None | 1.32A | 4kowA-4fcgA:undetectable | 4kowA-4fcgA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r2b | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Ochrobactrumanthropi) |
PF01547(SBP_bac_1) | 5 | PHE A 200GLY A 402ASN A 401SER A 405PHE A 233 | None | 1.16A | 4kowA-4r2bA:undetectable | 4kowA-4r2bA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhj | ENVELOPEGLYCOPROTEIN HENVELOPEGLYCOPROTEIN L (Humanalphaherpesvirus3) |
PF02489(Herpes_glycop_H)PF05259(Herpes_UL1)PF17488(Herpes_glycoH_C) | 5 | PHE A 149PRO B 143GLY A 313ASN A 317LEU A 226 | None | 1.11A | 4kowA-4xhjA:undetectable | 4kowA-4xhjA:11.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5boe | ENOLASE (Staphylococcusaureus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | GLY A 396ASN A 150MET A 149SER A 370LEU A 341 | NoneNoneNonePEP A 501 ( 4.7A)None | 1.25A | 4kowA-5boeA:undetectable | 4kowA-5boeA:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fn4 | NICASTRIN (Homo sapiens) |
PF05450(Nicastrin) | 5 | ARG A 117TYR A 94GLY A 89PHE A 210LEU A 212 | None | 1.03A | 4kowA-5fn4A:undetectable | 4kowA-5fn4A:12.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw7 | GLUCOSIDASE YGJK (Escherichiacoli) |
PF01204(Trehalase) | 5 | PRO A 31GLY A 55PHE A 33TYR A 195LEU A 59 | None | 1.33A | 4kowA-5gw7A:undetectable | 4kowA-5gw7A:13.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h1q | INNEXIN-6 (Caenorhabditiselegans) |
PF00876(Innexin) | 5 | PHE A 147GLY A 350SER A 355PHE A 165ARG A 161 | None | 0.99A | 4kowA-5h1qA:undetectable | 4kowA-5h1qA:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ij6 | LIPOATE--PROTEINLIGASE (Enterococcusfaecalis) |
PF03099(BPL_LplA_LipB)PF10437(Lip_prot_lig_C) | 5 | PHE A 319GLY A 285ASN A 46PHE A 331LEU A 335 | None | 1.41A | 4kowA-5ij6A:undetectable | 4kowA-5ij6A:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j04 | ENOLASE (Synechococcuselongatus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | GLY A 392ASN A 152MET A 151SER A 366LEU A 337 | NoneNoneNonePEP A 501 ( 4.5A)None | 1.14A | 4kowA-5j04A:undetectable | 4kowA-5j04A:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lun | 2-OXOGLUTARATE-DEPENDENTETHYLENE/SUCCINATE-FORMING ENZYME (Pseudomonassavastanoi) |
PF03171(2OG-FeII_Oxy)PF14226(DIOX_N) | 5 | PHE A 283ARG A 321GLY A 77TYR A 126LEU A 173 | ARG A 403 ( 4.2A)NoneNoneNoneOGA A 402 (-4.5A) | 1.50A | 4kowA-5lunA:undetectable | 4kowA-5lunA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5van | BETA-KLOTHO (Homo sapiens) |
no annotation | 5 | PHE A 379ASN A 438MET A 436PHE A 374TYR A 457 | None | 1.11A | 4kowA-5vanA:undetectable | 4kowA-5vanA:16.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vdb | ACETYLTRANSFERASEPA4794 (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 5 | ARG A 49TYR A 68GLY A 79ASN A 66TYR A 128 | 93M A 207 ( 4.3A)93M A 207 (-3.4A)93M A 207 (-3.5A)None93M A 207 (-4.9A) | 1.31A | 4kowA-5vdbA:32.3 | 4kowA-5vdbA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vdb | ACETYLTRANSFERASEPA4794 (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 12 | PHE A 27PRO A 31ARG A 49TYR A 68GLY A 79ASN A 80MET A 81SER A 116PHE A 118TYR A 128ARG A 141LEU A 151 | None93M A 207 (-4.0A)93M A 207 ( 4.3A)93M A 207 (-3.4A)93M A 207 (-3.5A)None93M A 207 (-4.9A)93M A 207 (-4.7A)None93M A 207 (-4.9A)SO4 A 206 (-3.0A)93M A 207 (-4.6A) | 0.24A | 4kowA-5vdbA:32.3 | 4kowA-5vdbA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vf4 | UNCHARACTERIZEDPROTEIN (Thermusaquaticus) |
PF03781(FGE-sulfatase) | 5 | GLY A 367ASN A 94SER A 290TYR A 293ARG A 206 | None | 1.31A | 4kowA-5vf4A:undetectable | 4kowA-5vf4A:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bo6 | - (-) |
no annotation | 5 | PHE A 549GLY A 506PHE A 514ARG A 480LEU A 478 | None | 1.04A | 4kowA-6bo6A:undetectable | 4kowA-6bo6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq1 | PHOSPHATIDYLINOSITOL4-KINASE III ALPHA(PI4KA) (Homo sapiens) |
no annotation | 5 | PHE A1737GLY A1894SER A1778PHE A1738LEU A1776 | None | 1.45A | 4kowA-6bq1A:undetectable | 4kowA-6bq1A:0.00 |