SIMILAR PATTERNS OF AMINO ACIDS FOR 4KOW_A_CFXA204_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3p MINOR COAT PROTEIN

(Escherichia
virus M13)
PF05357
(Phage_Coat_A)
5 PRO A 123
ASN A 120
SER A 172
TYR A 177
LEU A 106
None
1.04A 4kowA-1g3pA:
undetectable
4kowA-1g3pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 GLY A 392
ASN A 147
MET A 146
SER A 366
LEU A 337
None
1.23A 4kowA-1iyxA:
0.3
4kowA-1iyxA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jny ELONGATION FACTOR
1-ALPHA


(Sulfolobus
solfataricus)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
5 PRO A 195
GLY A  18
ASN A 152
PHE A  55
LEU A  59
GDP  A 500 (-4.3A)
GDP  A 500 (-3.2A)
GDP  A 500 (-3.2A)
None
None
1.47A 4kowA-1jnyA:
undetectable
4kowA-1jnyA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE


(Bacillus
anthracis)
PF00809
(Pterin_bind)
5 PRO A 212
GLY A 249
ASN A 207
PHE A 252
LEU A  21
None
1.49A 4kowA-1twwA:
0.2
4kowA-1twwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F)
PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike)
5 PRO A 372
TYR A 324
GLY A 346
ASN A 326
MET A 345
PRO  A 372 ( 1.1A)
TYR  A 324 ( 1.3A)
GLY  A 346 ( 0.0A)
ASN  A 326 ( 0.6A)
MET  A 345 ( 0.0A)
1.34A 4kowA-1v0fA:
0.0
4kowA-1v0fA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE


(Vibrio
proteolyticus)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
5 PRO A 740
GLY A 745
ASN A 763
SER A 308
LEU A 313
None
1.36A 4kowA-1v7vA:
1.1
4kowA-1v7vA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeg HYPOTHETICAL PROTEIN
AGR_PAT_140


(Agrobacterium
fabrum)
PF02586
(SRAP)
5 PHE A 154
PRO A 121
TYR A  30
GLY A  38
LEU A  51
None
1.46A 4kowA-2aegA:
0.0
4kowA-2aegA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 GLY A 394
ASN A 151
MET A 150
SER A 368
LEU A 339
None
1.22A 4kowA-2fymA:
0.0
4kowA-2fymA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ge3 PROBABLE
ACETYLTRANSFERASE


(Agrobacterium
tumefaciens)
PF00583
(Acetyltransf_1)
5 ARG A  76
GLY A  90
MET A  91
SER A 125
TYR A 137
None
None
ACO  A1301 (-3.9A)
None
None
1.45A 4kowA-2ge3A:
17.4
4kowA-2ge3A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G


(Homo sapiens)
PF00069
(Pkinase)
5 PHE A 300
PRO A 147
ASN A 149
PHE A 107
LEU A 213
None
1.44A 4kowA-2jamA:
undetectable
4kowA-2jamA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE


(Rauvolfia
serpentina)
PF00232
(Glyco_hydro_1)
5 PHE A 205
PRO A 208
ASN A 273
MET A 342
LEU A 246
None
1.27A 4kowA-2jf7A:
0.9
4kowA-2jf7A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A


(Homo sapiens)
PF04433
(SWIRM)
5 PHE A  25
GLY A  31
PHE A  39
ARG A  80
LEU A  77
None
1.41A 4kowA-2l3dA:
undetectable
4kowA-2l3dA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ


(Pseudomonas
aeruginosa)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 PHE A 138
GLY A 104
MET A 105
PHE A 136
LEU A 169
None
GDP  A1317 (-3.1A)
None
None
None
1.26A 4kowA-2vawA:
undetectable
4kowA-2vawA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN


(Azospirillum
brasilense)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
5 GLY A1370
ASN A1350
SER A 959
PHE A 915
LEU A 965
None
1.30A 4kowA-2vdcA:
undetectable
4kowA-2vdcA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE


(Arthrobacter
sp. KI72)
PF01425
(Amidase)
5 PRO A 427
ARG A 176
PHE A 308
ARG A 306
LEU A 309
None
1.36A 4kowA-3a2qA:
undetectable
4kowA-3a2qA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404


(Pyrococcus
horikoshii)
PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7)
5 PHE A 235
PRO A 233
GLY A 193
ASN A 644
LEU A 215
None
None
None
SO4  A 652 (-4.0A)
None
1.10A 4kowA-3af5A:
undetectable
4kowA-3af5A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb7 INTERPAIN A

(Prevotella
intermedia)
PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69)
5 TYR A 332
GLY A  75
SER A  77
PHE A  81
TYR A  56
None
1.21A 4kowA-3bb7A:
undetectable
4kowA-3bb7A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvb BACTERIOFERRITIN

(Brucella
abortus)
PF00210
(Ferritin)
5 PRO A  76
ARG A  78
GLY A  93
PHE A  16
TYR A 101
None
1.33A 4kowA-3fvbA:
undetectable
4kowA-3fvbA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1


(Prunus dulcis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 PHE A 342
ARG A 194
GLY A 112
ASN A 110
PHE A 330
HBX  A 530 ( 4.7A)
None
FAD  A 522 (-3.9A)
FAD  A 522 (-4.2A)
HBX  A 530 (-4.0A)
1.41A 4kowA-3gdnA:
undetectable
4kowA-3gdnA:
14.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kkw PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF00583
(Acetyltransf_1)
5 ARG A  49
TYR A  68
GLY A  79
ASN A  66
TYR A 128
EDO  A 175 ( 3.0A)
EDO  A 175 (-3.6A)
EDO  A 175 ( 3.6A)
None
EDO  A 176 ( 4.8A)
1.35A 4kowA-3kkwA:
32.0
4kowA-3kkwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kkw PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF00583
(Acetyltransf_1)
12 PHE A  27
PRO A  31
ARG A  49
TYR A  68
GLY A  79
ASN A  80
MET A  81
SER A 116
PHE A 118
TYR A 128
ARG A 141
LEU A 151
EDO  A 171 ( 4.5A)
EDO  A 175 (-4.3A)
EDO  A 175 ( 3.0A)
EDO  A 175 (-3.6A)
EDO  A 175 ( 3.6A)
EDO  A 175 ( 4.3A)
EDO  A 174 ( 4.8A)
SO4  A 161 (-4.8A)
None
EDO  A 176 ( 4.8A)
SO4  A 161 (-3.9A)
None
0.40A 4kowA-3kkwA:
32.0
4kowA-3kkwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kya PUTATIVE PHOSPHATASE

(Bacteroides
thetaiotaomicron)
PF01833
(TIG)
5 PHE A 356
ARG A 211
GLY A 273
ASN A 272
PHE A 338
None
EDO  A   1 (-4.6A)
None
EDO  A   1 (-3.7A)
None
1.38A 4kowA-3kyaA:
undetectable
4kowA-3kyaA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 PHE A 343
ARG A 194
GLY A 112
ASN A 110
PHE A 331
None
None
FAD  A 773 (-3.9A)
FAD  A 773 (-4.3A)
None
1.39A 4kowA-3redA:
undetectable
4kowA-3redA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh2 HYPOTHETICAL
TETR-LIKE
TRANSCRIPTIONAL
REGULATOR


(Shewanella
amazonensis)
PF00440
(TetR_N)
PF13972
(TetR)
5 TYR A  96
GLY A 156
MET A 153
PHE A  65
LEU A  61
None
UNL  A 301 ( 4.7A)
None
UNL  A 301 ( 4.2A)
None
1.33A 4kowA-3rh2A:
undetectable
4kowA-3rh2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp5 CDBFV

(Neocallimastix
patriciarum)
PF00457
(Glyco_hydro_11)
5 ARG A  61
TYR A 100
GLY A 101
PHE A 159
ARG A 148
None
1.40A 4kowA-3wp5A:
undetectable
4kowA-3wp5A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07952
(Toxin_trans)
5 PRO A 539
GLY A 115
ASN A 114
TYR A 328
LEU A 119
None
1.44A 4kowA-3zuqA:
undetectable
4kowA-3zuqA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 GLY A 392
ASN A 148
MET A 147
SER A 366
LEU A 337
None
1.16A 4kowA-4a3rA:
undetectable
4kowA-4a3rA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN


(Bacteroides
eggerthii)
no annotation 5 PHE A 664
GLY A 618
ASN A 639
PHE A 643
LEU A 626
None
1.48A 4kowA-4ecoA:
undetectable
4kowA-4ecoA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN


(Xanthomonas
euvesicatoria)
PF13855
(LRR_8)
5 GLY A 237
ASN A 259
MET A 239
PHE A 218
TYR A 161
None
1.32A 4kowA-4fcgA:
undetectable
4kowA-4fcgA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Ochrobactrum
anthropi)
PF01547
(SBP_bac_1)
5 PHE A 200
GLY A 402
ASN A 401
SER A 405
PHE A 233
None
1.16A 4kowA-4r2bA:
undetectable
4kowA-4r2bA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L


(Human
alphaherpesvirus
3)
PF02489
(Herpes_glycop_H)
PF05259
(Herpes_UL1)
PF17488
(Herpes_glycoH_C)
5 PHE A 149
PRO B 143
GLY A 313
ASN A 317
LEU A 226
None
1.11A 4kowA-4xhjA:
undetectable
4kowA-4xhjA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boe ENOLASE

(Staphylococcus
aureus)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 GLY A 396
ASN A 150
MET A 149
SER A 370
LEU A 341
None
None
None
PEP  A 501 ( 4.7A)
None
1.25A 4kowA-5boeA:
undetectable
4kowA-5boeA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens)
PF05450
(Nicastrin)
5 ARG A 117
TYR A  94
GLY A  89
PHE A 210
LEU A 212
None
1.03A 4kowA-5fn4A:
undetectable
4kowA-5fn4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli)
PF01204
(Trehalase)
5 PRO A  31
GLY A  55
PHE A  33
TYR A 195
LEU A  59
None
1.33A 4kowA-5gw7A:
undetectable
4kowA-5gw7A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1q INNEXIN-6

(Caenorhabditis
elegans)
PF00876
(Innexin)
5 PHE A 147
GLY A 350
SER A 355
PHE A 165
ARG A 161
None
0.99A 4kowA-5h1qA:
undetectable
4kowA-5h1qA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ij6 LIPOATE--PROTEIN
LIGASE


(Enterococcus
faecalis)
PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C)
5 PHE A 319
GLY A 285
ASN A  46
PHE A 331
LEU A 335
None
1.41A 4kowA-5ij6A:
undetectable
4kowA-5ij6A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j04 ENOLASE

(Synechococcus
elongatus)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 GLY A 392
ASN A 152
MET A 151
SER A 366
LEU A 337
None
None
None
PEP  A 501 ( 4.5A)
None
1.14A 4kowA-5j04A:
undetectable
4kowA-5j04A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME


(Pseudomonas
savastanoi)
PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N)
5 PHE A 283
ARG A 321
GLY A  77
TYR A 126
LEU A 173
ARG  A 403 ( 4.2A)
None
None
None
OGA  A 402 (-4.5A)
1.50A 4kowA-5lunA:
undetectable
4kowA-5lunA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens)
no annotation 5 PHE A 379
ASN A 438
MET A 436
PHE A 374
TYR A 457
None
1.11A 4kowA-5vanA:
undetectable
4kowA-5vanA:
16.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vdb ACETYLTRANSFERASE
PA4794


(Pseudomonas
aeruginosa)
PF00583
(Acetyltransf_1)
5 ARG A  49
TYR A  68
GLY A  79
ASN A  66
TYR A 128
93M  A 207 ( 4.3A)
93M  A 207 (-3.4A)
93M  A 207 (-3.5A)
None
93M  A 207 (-4.9A)
1.31A 4kowA-5vdbA:
32.3
4kowA-5vdbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vdb ACETYLTRANSFERASE
PA4794


(Pseudomonas
aeruginosa)
PF00583
(Acetyltransf_1)
12 PHE A  27
PRO A  31
ARG A  49
TYR A  68
GLY A  79
ASN A  80
MET A  81
SER A 116
PHE A 118
TYR A 128
ARG A 141
LEU A 151
None
93M  A 207 (-4.0A)
93M  A 207 ( 4.3A)
93M  A 207 (-3.4A)
93M  A 207 (-3.5A)
None
93M  A 207 (-4.9A)
93M  A 207 (-4.7A)
None
93M  A 207 (-4.9A)
SO4  A 206 (-3.0A)
93M  A 207 (-4.6A)
0.24A 4kowA-5vdbA:
32.3
4kowA-5vdbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf4 UNCHARACTERIZED
PROTEIN


(Thermus
aquaticus)
PF03781
(FGE-sulfatase)
5 GLY A 367
ASN A  94
SER A 290
TYR A 293
ARG A 206
None
1.31A 4kowA-5vf4A:
undetectable
4kowA-5vf4A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-)
no annotation 5 PHE A 549
GLY A 506
PHE A 514
ARG A 480
LEU A 478
None
1.04A 4kowA-6bo6A:
undetectable
4kowA-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)


(Homo sapiens)
no annotation 5 PHE A1737
GLY A1894
SER A1778
PHE A1738
LEU A1776
None
1.45A 4kowA-6bq1A:
undetectable
4kowA-6bq1A:
0.00