SIMILAR PATTERNS OF AMINO ACIDS FOR 4KOU_A_C04A207

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bih HEMOLIN

(Hyalophora
cecropia) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 GLY A 373
GLU A 389
THR A 390
 None
 0.55A 4kouA-1bihA:
0.0		 4kouA-1bihA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		3 GLY A 118
GLU A  93
THR A 113
 None
 0.58A 4kouA-1d6sA:
0.0		 4kouA-1d6sA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dt2 EXFOLIATIVE TOXIN B

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		3 GLY A 154
GLU A 182
THR A 181
 None
 0.47A 4kouA-1dt2A:
0.0		 4kouA-1dt2A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		3 GLY A  48
GLU A  39
THR A  38
 None
 0.52A 4kouA-1dubA:
0.0		 4kouA-1dubA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iab ASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		3 GLY A 150
GLU A 162
THR A 163
 None
 0.50A 4kouA-1iabA:
0.0		 4kouA-1iabA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1joy PROTEIN (ENVZ_ECOLI)

(Escherichia
coli) 		PF00512
(HisKA) 		3 GLY A 264
GLU A 257
THR A 256
 GLY  A 264 ( 0.0A)
GLU  A 257 ( 0.5A)
THR  A 256 ( 0.8A)
 0.56A 4kouA-1joyA:
undetectable		 4kouA-1joyA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 GLY A 394
GLU A 369
THR A 370
 None
 0.55A 4kouA-1mlzA:
0.7		 4kouA-1mlzA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9i MANGANESE CATALASE

(Lactobacillus
plantarum) 		PF05067
(Mn_catalase) 		3 GLY A  31
GLU A  35
THR A  36
 None
MN3  A 267 (-2.6A)
None
 0.48A 4kouA-1o9iA:
undetectable		 4kouA-1o9iA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwr MANNOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
subtilis) 		PF01238
(PMI_typeI) 		3 GLY A 170
GLU A 116
THR A 115
 None
ZN  A 604 (-2.7A)
None
 0.58A 4kouA-1qwrA:
0.0		 4kouA-1qwrA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc6 HYPOTHETICAL PROTEIN
YLBA

(Escherichia
coli) 		PF05899
(Cupin_3)
PF07883
(Cupin_2) 		3 GLY A1114
GLU A1082
THR A1083
 None
 0.53A 4kouA-1rc6A:
0.0		 4kouA-1rc6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc7 RIBONUCLEASE III

(Aquifex
aeolicus) 		PF00035
(dsrm)
PF14622
(Ribonucleas_3_3) 		3 GLY A 197
GLU A 187
THR A 195
 None
 0.59A 4kouA-1rc7A:
undetectable		 4kouA-1rc7A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 GLY A 606
GLU A 603
THR A 602
 None
 0.56A 4kouA-1sb3A:
undetectable		 4kouA-1sb3A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE

(Staphylococcus
aureus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 GLY A 308
GLU A 180
THR A 179
 None
 0.54A 4kouA-1tvzA:
undetectable		 4kouA-1tvzA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE

(Streptococcus
pneumoniae) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		3 GLY A  44
GLU A  52
THR A  49
 None
 0.41A 4kouA-1vqzA:
undetectable		 4kouA-1vqzA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 GLY A 321
GLU A 319
THR A 288
 None
CO  A1001 (-2.6A)
None
 0.49A 4kouA-1wn1A:
undetectable		 4kouA-1wn1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw0 MENKES
COPPER-TRANSPORTING
ATPASE

(Homo sapiens) 		PF00403
(HMA) 		3 GLY A  43
GLU A   4
THR A   5
 None
 0.37A 4kouA-2aw0A:
undetectable		 4kouA-2aw0A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwz THIOESTERASE FAMILY
PROTEIN

(Thermus
thermophilus) 		no annotation 3 GLY A  63
GLU A 114
THR A 113
 None
 0.49A 4kouA-2cwzA:
undetectable		 4kouA-2cwzA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8g CAPSID

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 GLY A 542
GLU A 721
THR A 720
 None
 0.48A 4kouA-2g8gA:
undetectable		 4kouA-2g8gA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gai DNA TOPOISOMERASE I

(Thermotoga
maritima) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 GLY A 396
GLU A 380
THR A 381
 None
 0.59A 4kouA-2gaiA:
undetectable		 4kouA-2gaiA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkd CALC

(Micromonospora
echinospora) 		no annotation 3 GLY A  60
GLU A  62
THR A  38
 None
 0.53A 4kouA-2gkdA:
undetectable		 4kouA-2gkdA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 GLY A  58
GLU A 574
THR A 575
 None
 0.54A 4kouA-2gskA:
undetectable		 4kouA-2gskA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqm GLUTATHIONE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLY A 252
GLU A 222
THR A 223
 None
 0.32A 4kouA-2hqmA:
undetectable		 4kouA-2hqmA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kl3 ALR3790 PROTEIN

(Nostoc sp. PCC
7120) 		PF00581
(Rhodanese) 		3 GLY A  35
GLU A 105
THR A 104
 None
 0.46A 4kouA-2kl3A:
undetectable		 4kouA-2kl3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyr FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
1

(Escherichia
coli) 		PF02302
(PTS_IIB) 		3 GLY A  45
GLU A  39
THR A  40
 None
 0.52A 4kouA-2kyrA:
undetectable		 4kouA-2kyrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxf UNCHARACTERIZED
PROTEIN

(Giardia
intestinalis) 		PF00708
(Acylphosphatase) 		3 GLY A  95
GLU A  56
THR A  53
 None
 0.50A 4kouA-2lxfA:
undetectable		 4kouA-2lxfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 GLY A 410
GLU A 412
THR A 413
 None
 0.59A 4kouA-2p6rA:
undetectable		 4kouA-2p6rA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qbu PRECORRIN-2
METHYLTRANSFERASE

(Methanothermobacter
thermautotrophicus) 		PF00590
(TP_methylase) 		3 GLY A   7
GLU A 126
THR A 125
 None
 0.51A 4kouA-2qbuA:
1.5		 4kouA-2qbuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r01 NITROREDUCTASE
FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF00881
(Nitroreductase) 		3 GLY A 186
GLU A 165
THR A 166
 None
EDO  A 213 (-2.9A)
None
 0.58A 4kouA-2r01A:
undetectable		 4kouA-2r01A:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT

(Bacillus
subtilis) 		PF02302
(PTS_IIB) 		3 GLY A  43
GLU A  37
THR A  38
 None
 0.47A 4kouA-2r48A:
undetectable		 4kouA-2r48A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4q PHOSPHOTRANSFERASE
SYSTEM (PTS)
FRUCTOSE-SPECIFIC
ENZYME IIABC
COMPONENT

(Bacillus
subtilis) 		PF02302
(PTS_IIB) 		3 GLY A 212
GLU A 206
THR A 207
 None
 0.48A 4kouA-2r4qA:
undetectable		 4kouA-2r4qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rck JUVENILE HORMONE
BINDING PROTEIN

(Galleria
mellonella) 		PF06585
(JHBP) 		3 GLY A 125
GLU A 147
THR A 148
 None
 0.59A 4kouA-2rckA:
undetectable		 4kouA-2rckA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF03308
(ArgK) 		3 GLY A 150
GLU A 242
THR A 243
 None
 0.57A 4kouA-2wwwA:
undetectable		 4kouA-2wwwA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		3 GLY A 138
GLU A 110
THR A 106
 SF4  A 602 (-3.6A)
None
SF4  A 602 ( 3.6A)
 0.57A 4kouA-2xdqA:
undetectable		 4kouA-2xdqA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		3 GLY A1106
GLU A1126
THR A1125
 None
None
PTR  A1124 ( 3.8A)
 0.53A 4kouA-2xkkA:
undetectable		 4kouA-2xkkA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		3 GLY A 152
GLU A 208
THR A 207
 None
 0.43A 4kouA-2yv2A:
undetectable		 4kouA-2yv2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H

(Homo sapiens) 		PF00179
(UQ_con) 		3 GLY A  67
GLU A 170
THR A 169
 None
 0.46A 4kouA-2z5dA:
undetectable		 4kouA-2z5dA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 GLY O 228
GLU O 230
THR O 222
 None
 0.53A 4kouA-2zf5O:
undetectable		 4kouA-2zf5O:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a57 THERMOSTABLE DIRECT
HEMOLYSIN 2

(Vibrio
parahaemolyticus) 		PF03347
(TDH) 		3 GLY A  62
GLU A  15
THR A  60
 None
 0.59A 4kouA-3a57A:
undetectable		 4kouA-3a57A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn3 INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		3 GLY B  81
GLU B  63
THR B  64
 None
 0.55A 4kouA-3bn3B:
undetectable		 4kouA-3bn3B:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		3 GLY A 196
GLU A  34
THR A  31
 None
 0.54A 4kouA-3c4qA:
undetectable		 4kouA-3c4qA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckk TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Homo sapiens) 		PF02390
(Methyltransf_4) 		3 GLY A  56
GLU A 209
THR A 208
 SAM  A 301 (-3.5A)
None
SAM  A 301 (-2.8A)
 0.57A 4kouA-3ckkA:
undetectable		 4kouA-3ckkA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		3 GLY A 525
GLU A 523
THR A 487
 None
MN  A 624 ( 2.5A)
None
 0.47A 4kouA-3ctzA:
undetectable		 4kouA-3ctzA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilw DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis) 		PF00521
(DNA_topoisoIV) 		3 GLY A 112
GLU A 131
THR A 130
 GOL  A   1 (-3.6A)
None
None
 0.58A 4kouA-3ilwA:
undetectable		 4kouA-3ilwA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER

(Porphyromonas
gingivalis) 		PF12704
(MacB_PCD) 		3 GLY A 105
GLU A 118
THR A 119
 TRS  A   1 (-3.4A)
None
None
 0.49A 4kouA-3is6A:
undetectable		 4kouA-3is6A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG

(Homo sapiens) 		PF03932
(CutC) 		3 GLY A 113
GLU A 167
THR A 143
 None
 0.54A 4kouA-3iwpA:
undetectable		 4kouA-3iwpA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix9 DIHYDROFOLATE
REDUCTASE

(Streptococcus
pneumoniae) 		PF00186
(DHFR_1) 		3 GLY A  76
GLU A  62
THR A  63
 None
 0.52A 4kouA-3ix9A:
undetectable		 4kouA-3ix9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jys SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 GLY A 375
GLU A 378
THR A 379
 None
 0.49A 4kouA-3jysA:
undetectable		 4kouA-3jysA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		3 GLY A 285
GLU A 385
THR A 386
 None
NAP  A 482 (-3.5A)
None
 0.48A 4kouA-3jz4A:
undetectable		 4kouA-3jz4A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE

(Pseudoalteromonas
atlantica) 		PF00171
(Aldedh) 		3 GLY A 286
GLU A 390
THR A 391
 None
 0.53A 4kouA-3k2wA:
undetectable		 4kouA-3k2wA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei) 		PF01593
(Amino_oxidase) 		3 GLY A 393
GLU A 388
THR A 389
 None
 0.54A 4kouA-3ka7A:
undetectable		 4kouA-3ka7A:
17.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kkw PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		3 GLY A  11
GLU A  14
THR A  15
 EDO  A 179 (-3.7A)
EDO  A 173 (-4.9A)
EDO  A 167 ( 3.0A)
 0.11A 4kouA-3kkwA:
31.9		 4kouA-3kkwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljb INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF01031
(Dynamin_M)
PF02212
(GED) 		3 GLY A 397
GLU A 394
THR A 395
 None
 0.55A 4kouA-3ljbA:
undetectable		 4kouA-3ljbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq0 PROASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		3 GLY A 150
GLU A 162
THR A 163
 None
 0.50A 4kouA-3lq0A:
undetectable		 4kouA-3lq0A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqb LOC792177 PROTEIN

(Danio rerio) 		PF01400
(Astacin) 		3 GLY A 156
GLU A 167
THR A 168
 None
 0.42A 4kouA-3lqbA:
undetectable		 4kouA-3lqbA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc3 DSRE/DSRF-LIKE
FAMILY PROTEIN

(Sulfolobus
solfataricus) 		PF02635
(DrsE) 		3 GLY A  87
GLU A  47
THR A  48
 MLY  A  84 ( 3.6A)
MLY  A  16 ( 3.4A)
None
 0.52A 4kouA-3mc3A:
undetectable		 4kouA-3mc3A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n79 PDUT

(Salmonella
enterica) 		PF00936
(BMC) 		3 GLY A 134
GLU A 101
THR A 102
 None
 0.50A 4kouA-3n79A:
undetectable		 4kouA-3n79A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntt CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF00740
(Parvo_coat) 		3 GLY A 510
GLU A 552
THR A 512
 None
 0.56A 4kouA-3nttA:
undetectable		 4kouA-3nttA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxs LAO/AO TRANSPORT
SYSTEM ATPASE

(Mycolicibacterium
smegmatis) 		PF03308
(ArgK) 		3 GLY A  58
GLU A 153
THR A 154
 None
 0.53A 4kouA-3nxsA:
1.6		 4kouA-3nxsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		3 GLY A 312
GLU A 360
THR A 359
 SO4  A 701 (-4.2A)
None
None
 0.59A 4kouA-3nzqA:
undetectable		 4kouA-3nzqA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 GLY A 409
GLU A  14
THR A  13
 None
 0.45A 4kouA-3pocA:
undetectable		 4kouA-3pocA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqu TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
suis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 GLY A 487
GLU A 475
THR A 474
 None
 0.56A 4kouA-3pquA:
undetectable		 4kouA-3pquA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6d PROLINE DIPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 GLY A 318
GLU A 316
THR A 285
 None
CA  A 502 (-3.7A)
None
 0.49A 4kouA-3q6dA:
undetectable		 4kouA-3q6dA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr3 ENDOGLUCANASE EG-II

(Trichoderma
reesei) 		PF00150
(Cellulase) 		3 GLY A 295
GLU A 305
THR A 304
 None
 0.59A 4kouA-3qr3A:
0.4		 4kouA-3qr3A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00171
(Aldedh) 		3 GLY A 272
GLU A 368
THR A 369
 None
 0.38A 4kouA-3rhdA:
undetectable		 4kouA-3rhdA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
halodurans) 		PF00275
(EPSP_synthase) 		3 GLY A 215
GLU A 192
THR A 191
 None
 0.55A 4kouA-3rmtA:
undetectable		 4kouA-3rmtA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		3 GLY A 129
GLU A 104
THR A 124
 None
 0.58A 4kouA-3tbhA:
undetectable		 4kouA-3tbhA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u NEUREGULIN 1
RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00008
(EGF)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 GLY G  44
GLU A   8
THR A   7
 None
 0.59A 4kouA-3u7uG:
undetectable		 4kouA-3u7uG:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8x TRANSFERRIN-BINDING
PROTEIN 1

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 GLY A 436
GLU A 401
THR A 402
 C8E  A1001 ( 4.2A)
None
None
 0.59A 4kouA-3v8xA:
undetectable		 4kouA-3v8xA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 GLY A 490
GLU A 493
THR A 494
 None
 0.49A 4kouA-3viuA:
undetectable		 4kouA-3viuA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A

(Schizosaccharomyces
pombe) 		PF08662
(eIF2A) 		3 GLY A 226
GLU A 247
THR A 248
 None
 0.56A 4kouA-3wj9A:
undetectable		 4kouA-3wj9A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bd9 CARBOXYPEPTIDASE
INHIBITOR SMCI

(Sabellastarte
magnifica) 		PF00014
(Kunitz_BPTI) 		3 GLY B  91
GLU B  27
THR B  26
 None
 0.52A 4kouA-4bd9B:
undetectable		 4kouA-4bd9B:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		3 GLY A  88
GLU A  97
THR A  96
 None
 0.58A 4kouA-4ccdA:
undetectable		 4kouA-4ccdA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckk DNA GYRASE SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV) 		3 GLY A 105
GLU A 124
THR A 123
 None
 0.57A 4kouA-4ckkA:
undetectable		 4kouA-4ckkA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 GLY A 527
GLU A 520
THR A 519
 None
 0.58A 4kouA-4d8mA:
undetectable		 4kouA-4d8mA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		3 GLY A 106
GLU A 125
THR A 124
 None
 0.54A 4kouA-4ddqA:
undetectable		 4kouA-4ddqA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 GLY A 337
GLU A 335
THR A 304
 None
UNX  A 420 (-2.0A)
None
 0.56A 4kouA-4egeA:
undetectable		 4kouA-4egeA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		3 GLY A  46
GLU A  21
THR A  20
 None
 0.57A 4kouA-4g3mA:
undetectable		 4kouA-4g3mA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		3 GLY A 192
GLU A 190
THR A 189
 None
 0.55A 4kouA-4gpgA:
undetectable		 4kouA-4gpgA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE

(Trichormus
variabilis) 		PF00171
(Aldedh) 		3 GLY A 260
GLU A 361
THR A 362
 None
 0.55A 4kouA-4h7nA:
undetectable		 4kouA-4h7nA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		3 GLY A 436
GLU A 118
THR A 117
 None
 0.55A 4kouA-4haqA:
undetectable		 4kouA-4haqA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij5 PHOSPHOSERINE
PHOSPHATASE 1

(Hydrogenobacter
thermophilus) 		PF00300
(His_Phos_1) 		3 GLY A  32
GLU A  65
THR A  62
 None
 0.57A 4kouA-4ij5A:
undetectable		 4kouA-4ij5A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iov CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		3 GLY A 541
GLU A 720
THR A 719
 None
 0.59A 4kouA-4iovA:
undetectable		 4kouA-4iovA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdz SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C)
PF17210
(SdrD_B) 		3 GLY A 296
GLU A 401
THR A 402
 None
 0.49A 4kouA-4jdzA:
undetectable		 4kouA-4jdzA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		3 GLY A  61
GLU A 166
THR A 167
 None
 0.45A 4kouA-4je0A:
undetectable		 4kouA-4je0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		3 GLY A 139
GLU A  99
THR A  96
 None
None
SU6  A 701 (-2.9A)
 0.56A 4kouA-4jlcA:
undetectable		 4kouA-4jlcA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		3 GLY A 281
GLU A 379
THR A 380
 None
 0.54A 4kouA-4jz6A:
undetectable		 4kouA-4jz6A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k8l PROLINE RACEMASE

(Ochrobactrum
anthropi) 		PF05544
(Pro_racemase) 		3 GLY A 239
GLU A 228
THR A 227
 None
 0.50A 4kouA-4k8lA:
undetectable		 4kouA-4k8lA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n58 PECTOCIN M2

(Pectobacterium
carotovorum) 		PF00111
(Fer2)
PF14859
(Colicin_M) 		3 GLY A 219
GLU A 204
THR A 203
 None
 0.56A 4kouA-4n58A:
undetectable		 4kouA-4n58A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 GLY A 445
GLU A 433
THR A 432
 None
 0.59A 4kouA-4o4xA:
undetectable		 4kouA-4o4xA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oib INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		3 GLY A  81
GLU A  63
THR A  64
 None
 0.52A 4kouA-4oibA:
undetectable		 4kouA-4oibA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 GLY A 367
GLU A  47
THR A  48
 None
 0.58A 4kouA-4oqjA:
undetectable		 4kouA-4oqjA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		3 GLY B1106
GLU B1125
THR B1124
 None
 0.55A 4kouA-4plbB:
undetectable		 4kouA-4plbB:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		3 GLY A 284
GLU A 279
THR A 280
 None
 0.45A 4kouA-4pxqA:
undetectable		 4kouA-4pxqA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 GLY B 671
GLU B 470
THR B 469
 None
 0.56A 4kouA-4qiwB:
undetectable		 4kouA-4qiwB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgz XAA-PRO
AMINOPEPTIDASE

(Thermococcus
sibiricus) 		no annotation 3 GLY A 335
GLU A 333
THR A 302
 None
ZN  A 401 (-3.9A)
None
 0.51A 4kouA-4rgzA:
undetectable		 4kouA-4rgzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLY A 222
GLU A 244
THR A 245
 None
 0.59A 4kouA-4rjkA:
undetectable		 4kouA-4rjkA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		3 GLY P 524
GLU P 522
THR P 485
 None
ZN  P 702 ( 2.6A)
None
 0.59A 4kouA-4s2tP:
undetectable		 4kouA-4s2tP:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3

(Escherichia
coli) 		PF02302
(PTS_IIB) 		3 GLY A  44
GLU A  38
THR A  39
 None
 0.56A 4kouA-4tn5A:
undetectable		 4kouA-4tn5A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6h HEAVY CHAIN OF
MURINE ANTI-VACCINIA
L1 IGG2A ANTIBODY
M12B9

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLY A  49
GLU A  59
THR A  58
 None
 0.46A 4kouA-4u6hA:
undetectable		 4kouA-4u6hA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN

(Enterococcus
faecalis) 		PF00781
(DAGK_cat) 		3 GLY A  43
GLU A  41
THR A  40
 AMP  A 401 ( 3.5A)
None
AMP  A 401 (-3.9A)
 0.59A 4kouA-4werA:
undetectable		 4kouA-4werA:
20.00