SIMILAR PATTERNS OF AMINO ACIDS FOR 4KOU_A_C04A206_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jny ELONGATION FACTOR
1-ALPHA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 PRO A 195
GLY A  18
ASN A 152
PHE A  55
LEU A  59
 GDP  A 500 (-4.3A)
GDP  A 500 (-3.2A)
GDP  A 500 (-3.2A)
None
None
 1.43A 4kouA-1jnyA:
undetectable		 4kouA-1jnyA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xip NUCLEOPORIN NUP159

(Saccharomyces
cerevisiae) 		PF16755
(NUP214) 		5 PHE A 269
TYR A 243
PRO A 268
GLY A 231
ASN A 232
 None
 1.46A 4kouA-1xipA:
0.0		 4kouA-1xipA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeg HYPOTHETICAL PROTEIN
AGR_PAT_140

(Agrobacterium
fabrum) 		PF02586
(SRAP) 		5 PHE A 154
PRO A 121
TYR A  30
GLY A  38
LEU A  51
 None
 1.45A 4kouA-2aegA:
0.0		 4kouA-2aegA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bma GLUTAMATE
DEHYDROGENASE
(NADP+)

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 PHE A 143
TYR A 175
GLY A 170
PHE A  94
LEU A  92
 None
 1.39A 4kouA-2bmaA:
0.0		 4kouA-2bmaA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE A 300
PRO A 147
ASN A 149
PHE A 107
LEU A 213
 None
 1.44A 4kouA-2jamA:
0.0		 4kouA-2jamA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l29 INSULIN-LIKE GROWTH
FACTOR 2 RECEPTOR
VARIANT

(Homo sapiens) 		PF00878
(CIMR) 		5 TYR A1549
GLY A1564
ASN A1556
PHE A1638
LEU A1636
 None
 1.32A 4kouA-2l29A:
undetectable		 4kouA-2l29A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF04433
(SWIRM) 		5 PHE A  25
GLY A  31
PHE A  39
ARG A  80
LEU A  77
 None
 1.40A 4kouA-2l3dA:
undetectable		 4kouA-2l3dA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		5 PHE A 459
TYR A 466
TYR A 108
GLY A 470
PHE A 406
 None
 1.34A 4kouA-2pyxA:
0.0		 4kouA-2pyxA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli;
[Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 PHE A  61
TYR A 153
PHE A 148
ARG A  79
LEU A  93
 None
 1.33A 4kouA-2yfhA:
0.0		 4kouA-2yfhA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		5 PRO A 427
ARG A 176
PHE A 308
ARG A 306
LEU A 309
 None
 1.39A 4kouA-3a2qA:
0.0		 4kouA-3a2qA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PHE A 342
ARG A 194
GLY A 112
ASN A 110
PHE A 330
 HBX  A 530 ( 4.7A)
None
FAD  A 522 (-3.9A)
FAD  A 522 (-4.2A)
HBX  A 530 (-4.0A)
 1.41A 4kouA-3gdnA:
undetectable		 4kouA-3gdnA:
14.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kkw PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		10 PHE A  27
TYR A  30
PRO A  31
ARG A  49
TYR A  68
GLY A  79
ASN A  80
PHE A 118
ARG A 141
LEU A 151
 EDO  A 171 ( 4.5A)
EDO  A 170 (-4.5A)
EDO  A 175 (-4.3A)
EDO  A 175 ( 3.0A)
EDO  A 175 (-3.6A)
EDO  A 175 ( 3.6A)
EDO  A 175 ( 4.3A)
None
SO4  A 161 (-3.9A)
None
 0.41A 4kouA-3kkwA:
31.9		 4kouA-3kkwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis) 		PF00120
(Gln-synt_C)
PF12437
(GSIII_N) 		5 PHE A 169
TYR A 179
PRO A  93
ASN A 481
PHE A  91
 None
 1.41A 4kouA-3o6xA:
undetectable		 4kouA-3o6xA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PHE A 343
ARG A 194
GLY A 112
ASN A 110
PHE A 331
 None
None
FAD  A 773 (-3.9A)
FAD  A 773 (-4.3A)
None
 1.40A 4kouA-3redA:
undetectable		 4kouA-3redA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum) 		PF00491
(Arginase) 		5 PRO A  30
ARG A  48
GLY A  67
PHE A 168
LEU A 172
 None
 1.28A 4kouA-3sl1A:
undetectable		 4kouA-3sl1A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 PHE A 438
ARG A 376
TYR A 405
GLY A 407
ARG A  47
 None
None
None
None
CL  A1590 (-4.3A)
 1.48A 4kouA-3zo9A:
undetectable		 4kouA-3zo9A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 5 PHE A 664
GLY A 618
ASN A 639
PHE A 643
LEU A 626
 None
 1.46A 4kouA-4ecoA:
undetectable		 4kouA-4ecoA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF05259
(Herpes_UL1)
PF17488
(Herpes_glycoH_C) 		5 PHE A 149
PRO B 143
GLY A 313
ASN A 317
LEU A 226
 None
 1.11A 4kouA-4xhjA:
undetectable		 4kouA-4xhjA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		5 ARG A 117
TYR A  94
GLY A  89
PHE A 210
LEU A 212
 None
 1.10A 4kouA-5fn4A:
undetectable		 4kouA-5fn4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 PHE A 146
TYR A 178
GLY A 173
PHE A  97
LEU A  95
 None
 1.49A 4kouA-5ijzA:
undetectable		 4kouA-5ijzA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqw 4-AMINOBUTYRATE
TRANSAMINASE

(Pseudomonas) 		PF00202
(Aminotran_3) 		5 TYR A 241
PRO A 237
ARG A 149
GLY A 225
LEU A 268
 None
 1.47A 4kouA-5kqwA:
undetectable		 4kouA-5kqwA:
16.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vdb ACETYLTRANSFERASE
PA4794

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		10 PHE A  27
TYR A  30
PRO A  31
ARG A  49
TYR A  68
GLY A  79
ASN A  80
PHE A 118
ARG A 141
LEU A 151
 None
None
93M  A 207 (-4.0A)
93M  A 207 ( 4.3A)
93M  A 207 (-3.4A)
93M  A 207 (-3.5A)
None
None
SO4  A 206 (-3.0A)
93M  A 207 (-4.6A)
 0.29A 4kouA-5vdbA:
32.0		 4kouA-5vdbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 5 PHE A 553
PRO A 550
GLY A 604
ASN A 584
PHE A 552
 GOL  A 805 (-4.4A)
None
None
None
None
 1.34A 4kouA-5z06A:
undetectable		 4kouA-5z06A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 5 PHE A 549
GLY A 506
PHE A 514
ARG A 480
LEU A 478
 None
 1.09A 4kouA-6bo6A:
undetectable		 4kouA-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cw5 RIBOKINASE

(Cryptococcus
neoformans) 		no annotation 5 PHE A 162
PRO A 164
GLY A 189
ASN A 187
LEU A 173
 None
 0.96A 4kouA-6cw5A:
undetectable		 4kouA-6cw5A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 5 TYR A1184
GLY A1180
ASN A1179
PHE A1176
LEU A1137
 None
 1.44A 4kouA-6eojA:
undetectable		 4kouA-6eojA:
8.31