SIMILAR PATTERNS OF AMINO ACIDS FOR 4KOT_A_CE3A205_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ghs | 1,3-BETA-GLUCANASE (Hordeum vulgare) |
PF00332(Glyco_hydro_17) | 5 | GLY A 92ASN A 93ILE A 103TYR A 148LEU A 156 | None | 1.33A | 4kotA-1ghsA:0.0 | 4kotA-1ghsA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jny | ELONGATION FACTOR1-ALPHA (Sulfolobussolfataricus) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 5 | PRO A 195GLY A 18ASN A 152PHE A 55LEU A 59 | GDP A 500 (-4.3A)GDP A 500 (-3.2A)GDP A 500 (-3.2A)NoneNone | 1.48A | 4kotA-1jnyA:undetectable | 4kotA-1jnyA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k1d | D-HYDANTOINASE (Geobacillusstearothermophilus) |
PF01979(Amidohydro_1) | 5 | CYH A 48PRO A 398GLY A 8ILE A 10LEU A 361 | None | 1.44A | 4kotA-1k1dA:0.0 | 4kotA-1k1dA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nw5 | MODIFICATIONMETHYLASE RSRI (Rhodobactersphaeroides) |
PF01555(N6_N4_Mtase) | 5 | GLY A 106ILE A 159PHE A 162ARG A 127LEU A 134 | None | 1.09A | 4kotA-1nw5A:0.0 | 4kotA-1nw5A:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tkl | COPROPORPHYRINOGENIII OXIDASE (Saccharomycescerevisiae) |
PF01218(Coprogen_oxidas) | 5 | PHE A 269ARG A 135GLY A 153ASN A 133ILE A 211 | None | 1.09A | 4kotA-1tklA:undetectable | 4kotA-1tklA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tu7 | GLUTATHIONES-TRANSFERASE 2 (Onchocercavolvulus) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | ARG A 95GLY A 64ILE A 60ARG A 18LEU A 5 | GSH A1001 (-3.6A)NoneNoneNoneNone | 1.38A | 4kotA-1tu7A:undetectable | 4kotA-1tu7A:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tww | DHPS,DIHYDROPTEROATESYNTHASE (Bacillusanthracis) |
PF00809(Pterin_bind) | 6 | PRO A 212GLY A 249ASN A 207ILE A 246PHE A 252LEU A 21 | None | 1.49A | 4kotA-1twwA:0.4 | 4kotA-1twwA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uag | UDP-N-ACETYLMURAMOYL-L-ALANINE/:D-GLUTAMATE LIGASE (Escherichiacoli) |
PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | GLY A 111ASN A 178ILE A 201TYR A 202LEU A 278 | KCX A 198 ( 3.9A)NoneKCX A 198 ( 3.6A)NoneNone | 1.17A | 4kotA-1uagA:0.0 | 4kotA-1uagA:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vjg | PUTATIVE LIPASE FROMTHE G-D-S-L FAMILY (Nostoc sp. PCC7120) |
PF13472(Lipase_GDSL_2) | 5 | CYH A 27PRO A 25ARG A 33TYR A 188GLY A 29 | None | 1.41A | 4kotA-1vjgA:0.6 | 4kotA-1vjgA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wza | ALPHA-AMYLASE A (Halothermothrixorenii) |
PF00128(Alpha-amylase) | 5 | TYR A 34GLY A 32ASN A 77ILE A 321PHE A 28 | None | 1.24A | 4kotA-1wzaA:undetectable | 4kotA-1wzaA:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aeg | HYPOTHETICAL PROTEINAGR_PAT_140 (Agrobacteriumfabrum) |
PF02586(SRAP) | 5 | PHE A 154PRO A 121TYR A 30GLY A 38ILE A 24 | None | 1.07A | 4kotA-2aegA:undetectable | 4kotA-2aegA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aeg | HYPOTHETICAL PROTEINAGR_PAT_140 (Agrobacteriumfabrum) |
PF02586(SRAP) | 5 | PHE A 154PRO A 121TYR A 30GLY A 38LEU A 51 | None | 1.49A | 4kotA-2aegA:undetectable | 4kotA-2aegA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bf6 | EXO-ALPHA-SIALIDASE (Clostridiumperfringens) |
PF13088(BNR_2) | 5 | CYH A 657GLY A 667ILE A 681ARG A 302LEU A 254 | None | 1.29A | 4kotA-2bf6A:undetectable | 4kotA-2bf6A:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bjs | ISOPENICILLIN NSYNTHETASE (Aspergillusnidulans) |
PF03171(2OG-FeII_Oxy)PF14226(DIOX_N) | 5 | GLY A 254ILE A 220PHE A 41TYR A 160LEU A 250 | None | 1.36A | 4kotA-2bjsA:undetectable | 4kotA-2bjsA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bm3 | SCAFFOLDING DOCKERINBINDING PROTEIN A (Ruminiclostridiumthermocellum) |
PF00963(Cohesin) | 5 | GLY A 146ASN A 42ILE A 144PHE A 150TYR A 160 | NoneNoneNoneIPA A1167 ( 4.5A)None | 1.24A | 4kotA-2bm3A:undetectable | 4kotA-2bm3A:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ckf | RING-HYDROXYLATINGDIOXYGENASE BETASUBUNIT (Sphingomonassp. CHY-1) |
PF00866(Ring_hydroxyl_B) | 5 | GLY B 30ILE B 99PHE B 173TYR B 101ARG B 84 | None | 1.36A | 4kotA-2ckfB:undetectable | 4kotA-2ckfB:25.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jam | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE 1G (Homo sapiens) |
PF00069(Pkinase) | 5 | PHE A 300ASN A 149ILE A 161PHE A 107LEU A 213 | None | 1.21A | 4kotA-2jamA:undetectable | 4kotA-2jamA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jam | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE 1G (Homo sapiens) |
PF00069(Pkinase) | 5 | PHE A 300PRO A 147ASN A 149PHE A 107LEU A 213 | None | 1.47A | 4kotA-2jamA:undetectable | 4kotA-2jamA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l3d | LYSINE-SPECIFICHISTONE DEMETHYLASE1A (Homo sapiens) |
PF04433(SWIRM) | 5 | PHE A 25GLY A 31PHE A 39ARG A 80LEU A 77 | None | 1.39A | 4kotA-2l3dA:undetectable | 4kotA-2l3dA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l4r | POTASSIUMVOLTAGE-GATEDCHANNEL SUBFAMILY HMEMBER 2 (Homo sapiens) |
PF13426(PAS_9) | 5 | PHE A 106GLY A 47ILE A 30PHE A 98LEU A 69 | None | 1.41A | 4kotA-2l4rA:undetectable | 4kotA-2l4rA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n3w | 26S PROTEASOMEREGULATORY SUBUNITRPN1 (Saccharomycescerevisiae) |
PF01851(PC_rep) | 5 | CYH A 538GLY A 540ILE A 546PHE A 534LEU A 506 | None | 1.45A | 4kotA-2n3wA:undetectable | 4kotA-2n3wA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vx4 | CELLVIBRIO JAPONICUSMANNANASE CJMAN26C (Cellvibriojaponicus) |
PF02156(Glyco_hydro_26) | 5 | PRO A 415TYR A 418GLY A 148TYR A 114LEU A 81 | None | 1.44A | 4kotA-2vx4A:undetectable | 4kotA-2vx4A:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2q | 6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE (Arthrobactersp. KI72) |
PF01425(Amidase) | 5 | PRO A 427ARG A 176PHE A 308ARG A 306LEU A 309 | None | 1.43A | 4kotA-3a2qA:0.2 | 4kotA-3a2qA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c41 | AMINO ACID ABCTRANSPORTER (ARTP) (Geobacillusstearothermophilus) |
PF00005(ABC_tran) | 5 | PRO J 35GLY J 39ILE J 20PHE J 208ARG J 231 | NoneANP J 601 (-3.2A)NoneNoneNone | 1.16A | 4kotA-3c41J:undetectable | 4kotA-3c41J:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d8m | BASEPLATE PROTEIN,RECEPTOR BINDINGPROTEIN (Lactococcusphage TP901-1;Lactococcusvirus P2) |
PF08931(Caudo_bapla_RBP) | 5 | PHE A 132TYR A 162ILE A 88PHE A 91LEU A 77 | None | 1.43A | 4kotA-3d8mA:undetectable | 4kotA-3d8mA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3da0 | CLEAVED CHIMERICRECEPTOR BINDINGPROTEIN FROMBACTERIOPHAGESTP901-1 AND P2 (Lactococcusphage TP901-1;Lactococcusvirus P2) |
PF08931(Caudo_bapla_RBP) | 5 | PHE A 132TYR A 162ILE A 88PHE A 91LEU A 77 | None | 1.46A | 4kotA-3da0A:undetectable | 4kotA-3da0A:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dsm | UNCHARACTERIZEDPROTEIN BACUNI_02894 (Bacteroidesuniformis) |
no annotation | 5 | PHE A 227ILE A 135TYR A 112ARG A 167LEU A 169 | None | 1.36A | 4kotA-3dsmA:undetectable | 4kotA-3dsmA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ehc | SNOAL-LIKEPOLYKETIDE CYCLASE (Agrobacteriumfabrum) |
PF07366(SnoaL) | 5 | ARG A 36ILE A 110TYR A 103ARG A 44LEU A 23 | SO4 A 130 (-3.7A)NoneNoneNoneNone | 1.33A | 4kotA-3ehcA:undetectable | 4kotA-3ehcA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ehm | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF12741(SusD-like) | 5 | PHE A 155PRO A 140GLY A 509ILE A 512PHE A 489 | None | 1.46A | 4kotA-3ehmA:undetectable | 4kotA-3ehmA:14.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fvb | BACTERIOFERRITIN (Brucellaabortus) |
PF00210(Ferritin) | 5 | PRO A 76ARG A 78GLY A 93PHE A 16TYR A 101 | None | 1.29A | 4kotA-3fvbA:undetectable | 4kotA-3fvbA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdn | R-OXYNITRILE LYASEISOENZYME 1 (Prunus dulcis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | PHE A 342ARG A 194GLY A 112ASN A 110PHE A 330 | HBX A 530 ( 4.7A)NoneFAD A 522 (-3.9A)FAD A 522 (-4.2A)HBX A 530 (-4.0A) | 1.43A | 4kotA-3gdnA:undetectable | 4kotA-3gdnA:14.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ht4 | ALUMINUM RESISTANCEPROTEIN (Bacillus cereus) |
PF06838(Met_gamma_lyase) | 5 | PHE A 213PRO A 235GLY A 244ILE A 246PHE A 78 | None | 1.34A | 4kotA-3ht4A:undetectable | 4kotA-3ht4A:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ik4 | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Herpetosiphonaurantiacus) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | PRO A 324GLY A 295ILE A 293PHE A 336LEU A 343 | None | 0.95A | 4kotA-3ik4A:undetectable | 4kotA-3ik4A:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3irz | URO-ADHERENCE FACTORA (Staphylococcussaprophyticus) |
PF17210(SdrD_B) | 5 | PRO A 729GLY A 473ILE A 476TYR A 495LEU A 734 | None | 1.31A | 4kotA-3irzA:undetectable | 4kotA-3irzA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb8 | COAT PROTEIN (Maize chloroticmottle virus) |
PF00729(Viral_coat) | 5 | PHE A 168CYH A 71PRO A 190ILE A 211PHE A 103 | None | 1.44A | 4kotA-3jb8A:1.0 | 4kotA-3jb8A:22.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kkw | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 6 | ARG A 49TYR A 68GLY A 79ASN A 66ILE A 115TYR A 128 | EDO A 175 ( 3.0A)EDO A 175 (-3.6A)EDO A 175 ( 3.6A)NoneNoneEDO A 176 ( 4.8A) | 1.31A | 4kotA-3kkwA:31.9 | 4kotA-3kkwA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kkw | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 5 | CYH A 29PRO A 31ARG A 49ASN A 80PHE A 27 | EDO A 163 ( 3.5A)EDO A 175 (-4.3A)EDO A 175 ( 3.0A)EDO A 175 ( 4.3A)EDO A 171 ( 4.5A) | 1.41A | 4kotA-3kkwA:31.9 | 4kotA-3kkwA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kkw | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 12 | PHE A 27CYH A 29PRO A 31ARG A 49TYR A 68GLY A 79ASN A 80ILE A 115PHE A 118TYR A 128ARG A 141LEU A 151 | EDO A 171 ( 4.5A)EDO A 163 ( 3.5A)EDO A 175 (-4.3A)EDO A 175 ( 3.0A)EDO A 175 (-3.6A)EDO A 175 ( 3.6A)EDO A 175 ( 4.3A)NoneNoneEDO A 176 ( 4.8A)SO4 A 161 (-3.9A)None | 0.36A | 4kotA-3kkwA:31.9 | 4kotA-3kkwA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lew | SUSD-LIKECARBOHYDRATE BINDINGPROTEIN (Bacteroidesvulgatus) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 5 | ARG A 71GLY A 427ILE A 431PHE A 148TYR A 236 | None | 1.33A | 4kotA-3lewA:undetectable | 4kotA-3lewA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mm5 | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT ALPHA (Archaeoglobusfulgidus) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | PRO A 102GLY A 134ILE A 137PHE A 160LEU A 115 | NoneSRM A 580 (-4.1A)NoneNoneNone | 1.05A | 4kotA-3mm5A:undetectable | 4kotA-3mm5A:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0t | DIPEPTIDYL PEPTIDASE2 (Homo sapiens) |
PF05577(Peptidase_S28) | 5 | PRO A 70GLY A 181PHE A 72ARG A 98LEU A 94 | None | 1.36A | 4kotA-3n0tA:undetectable | 4kotA-3n0tA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n92 | ALPHA-AMYLASE, GH57FAMILY (Thermococcuskodakarensis) |
PF03065(Glyco_hydro_57)PF09210(DUF1957) | 5 | PRO A 248GLY A 347ILE A 349PHE A 259LEU A 386 | None | 1.43A | 4kotA-3n92A:undetectable | 4kotA-3n92A:13.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3omn | CYTOCHROME COXIDASE, AA3 TYPE,SUBUNIT I (Rhodobactersphaeroides) |
PF00115(COX1) | 5 | PHE A 212GLY A 204ASN A 207ILE A 239PHE A 233 | None | 1.47A | 4kotA-3omnA:0.5 | 4kotA-3omnA:14.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3v | PHOSPHOGLYCERATEKINASE (Campylobacterjejuni) |
PF00162(PGK) | 5 | PRO A 322GLY A 352ASN A 320ILE A 372ARG A 362 | None | 1.48A | 4kotA-3q3vA:undetectable | 4kotA-3q3vA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3red | HYDROXYNITRILE LYASE (Prunus mume) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | PHE A 343ARG A 194GLY A 112ASN A 110PHE A 331 | NoneNoneFAD A 773 (-3.9A)FAD A 773 (-4.3A)None | 1.42A | 4kotA-3redA:undetectable | 4kotA-3redA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rw9 | SPERMIDINE SYNTHASE (Homo sapiens) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | CYH A 205TYR A 233GLY A 207ILE A 246TYR A 79 | NoneNoneNoneNoneDSH A 303 ( 4.9A) | 1.27A | 4kotA-3rw9A:0.8 | 4kotA-3rw9A:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5s | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Sorangiumcellulosum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | PRO A 327GLY A 298ILE A 296PHE A 339LEU A 346 | None | 1.01A | 4kotA-3s5sA:undetectable | 4kotA-3s5sA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sl1 | ARGINASE (Plasmodiumfalciparum) |
PF00491(Arginase) | 5 | PRO A 30ARG A 48GLY A 67PHE A 168LEU A 172 | None | 1.31A | 4kotA-3sl1A:undetectable | 4kotA-3sl1A:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vte | TETRAHYDROCANNABINOLIC ACID SYNTHASE (Cannabis sativa) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | GLY A 188ASN A 483ILE A 431PHE A 511LEU A 518 | NoneFAD A 607 (-3.3A)NoneNoneNone | 1.13A | 4kotA-3vteA:undetectable | 4kotA-3vteA:14.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c51 | CATALASE-PEROXIDASE (Mycobacteriumtuberculosis) |
PF00141(peroxidase) | 5 | PRO A 432TYR A 426GLY A 184ILE A 416PHE A 181 | None | 0.88A | 4kotA-4c51A:undetectable | 4kotA-4c51A:12.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cok | PYRUVATEDECARBOXYLASE (Gluconacetobacterdiazotrophicus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | PRO A 426TYR A 60GLY A 420ASN A 421ILE A 45 | None | 1.29A | 4kotA-4cokA:undetectable | 4kotA-4cokA:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cp6 | CHOLINE BINDINGPROTEIN PCPA (Streptococcuspneumoniae) |
PF13306(LRR_5) | 5 | TYR A 337GLY A 338ASN A 339ARG A 232LEU A 233 | None | 0.96A | 4kotA-4cp6A:undetectable | 4kotA-4cp6A:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eb5 | PROBABLE CYSTEINEDESULFURASE 2 (Archaeoglobusfulgidus) |
PF00266(Aminotran_5) | 5 | ARG A 287GLY A 152ASN A 291ARG A 295LEU A 337 | None | 1.39A | 4kotA-4eb5A:undetectable | 4kotA-4eb5A:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eco | UNCHARACTERIZEDPROTEIN (Bacteroideseggerthii) |
no annotation | 5 | PHE A 664GLY A 618ASN A 639PHE A 643LEU A 626 | None | 1.47A | 4kotA-4ecoA:undetectable | 4kotA-4ecoA:14.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ezi | UNCHARACTERIZEDPROTEIN (Legionellapneumophila) |
no annotation | 5 | PHE A 269GLY A 309ILE A 311PHE A 302LEU A 248 | NoneNoneNoneNonePEG A 501 ( 4.8A) | 1.34A | 4kotA-4eziA:2.8 | 4kotA-4eziA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pel | PENICILLIN G ACYLASESUBUNIT ALPHA (Kluyveracryocrescens) |
PF01804(Penicil_amidase) | 5 | PRO A 75GLY A 140ASN A 144ILE A 137PHE A 132 | None | 1.34A | 4kotA-4pelA:undetectable | 4kotA-4pelA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqv | ALGM1 (Sphingomonassp.) |
PF00528(BPD_transp_1) | 5 | PRO A 112GLY A 104ILE A 253PHE A 111LEU A 246 | None | 1.50A | 4kotA-4tqvA:undetectable | 4kotA-4tqvA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhj | ENVELOPEGLYCOPROTEIN HENVELOPEGLYCOPROTEIN L (Humanalphaherpesvirus3) |
PF02489(Herpes_glycop_H)PF05259(Herpes_UL1)PF17488(Herpes_glycoH_C) | 5 | PHE A 149PRO B 143GLY A 313ASN A 317LEU A 226 | None | 1.09A | 4kotA-4xhjA:0.0 | 4kotA-4xhjA:11.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z17 | ENOLASE (Chloroflexusaurantiacus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | PHE A 199PRO A 211GLY A 208ILE A 150LEU A 222 | None | 1.40A | 4kotA-4z17A:undetectable | 4kotA-4z17A:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5afu | DYNACTIN (Sus scrofa) |
PF00022(Actin) | 5 | PRO A 11GLY A 27ILE A 346PHE A 353LEU A 109 | None | 1.45A | 4kotA-5afuA:undetectable | 4kotA-5afuA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5avo | HOMOSERINEDEHYDROGENASE (Sulfurisphaeratokodaii) |
PF00742(Homoserine_dh)PF03447(NAD_binding_3) | 5 | ARG A 140GLY A 124ILE A 97PHE A 109TYR A 87 | None | 1.42A | 4kotA-5avoA:undetectable | 4kotA-5avoA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2i | ALR1585 PROTEIN (Nostoc sp. PCC7120) |
PF04261(Dyp_perox) | 5 | GLY A 423ASN A 407ILE A 449PHE A 387ARG A 365 | NoneNoneHEM A 501 (-4.1A)HEM A 501 (-4.0A)HEM A 501 (-2.7A) | 1.45A | 4kotA-5c2iA:undetectable | 4kotA-5c2iA:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d3m | ENERGY-COUPLINGFACTOR TRANSPORTERATP-BINDING PROTEINECFA2 (Lactobacillusdelbrueckii) |
PF00005(ABC_tran) | 5 | PHE B 5GLY B 221ILE B 224PHE B 28LEU B 216 | None | 1.34A | 4kotA-5d3mB:undetectable | 4kotA-5d3mB:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fn4 | NICASTRIN (Homo sapiens) |
PF05450(Nicastrin) | 5 | ARG A 117TYR A 94GLY A 89PHE A 210LEU A 212 | None | 1.08A | 4kotA-5fn4A:undetectable | 4kotA-5fn4A:12.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fok | IRON TRANSPORT OUTERMEMBRANE RECEPTOR (Pseudomonasaeruginosa) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | PRO A 253TYR A 651GLY A 652ASN A 653ILE A 660 | None | 1.39A | 4kotA-5fokA:undetectable | 4kotA-5fokA:11.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5z | ABC TRANSPORTER,SUBSTRATE-BINDINGPROTEIN (Streptococcuspneumoniae) |
PF01547(SBP_bac_1) | 5 | GLY A 234ASN A 180ILE A 230PHE A 238TYR A 299 | None | 1.30A | 4kotA-5g5zA:undetectable | 4kotA-5g5zA:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5z | ABC TRANSPORTER,SUBSTRATE-BINDINGPROTEIN (Streptococcuspneumoniae) |
PF01547(SBP_bac_1) | 5 | PHE A 242GLY A 234ASN A 180ILE A 230PHE A 238 | None | 1.36A | 4kotA-5g5zA:undetectable | 4kotA-5g5zA:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gyl | LEGUMIN-LIKE PROTEIN (Cicer arietinum) |
PF00190(Cupin_1) | 5 | GLY A 96ASN A 97ILE A 160PHE A 92LEU A 386 | None | 1.30A | 4kotA-5gylA:undetectable | 4kotA-5gylA:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hy6 | EUKARYOTICTRANSLATIONINITIATION FACTOR 5A (Spodopterafrugiperda) |
PF01287(eIF-5a) | 5 | PHE A 32CYH A 40GLY A 68ARG A 88LEU A 141 | None | 1.38A | 4kotA-5hy6A:undetectable | 4kotA-5hy6A:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5icl | LIPOATE--PROTEINLIGASE (Enterococcusfaecalis) |
PF03099(BPL_LplA_LipB)PF10437(Lip_prot_lig_C) | 5 | PHE A 260ARG A 96GLY A 287ILE A 291LEU A 329 | None | 1.15A | 4kotA-5iclA:undetectable | 4kotA-5iclA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ipw | OLIGOPEPTIDE ABCTRANSPORTER,PERIPLASMICOLIGOPEPTIDE-BINDINGPROTEIN, PUTATIVE (Thermotogamaritima) |
PF00496(SBP_bac_5) | 5 | PHE A 287GLY A 294ILE A 292ARG A 142LEU A 74 | None | 1.40A | 4kotA-5ipwA:1.1 | 4kotA-5ipwA:13.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jwf | ASP/GLU-SPECIFICDIPEPTIDYL-PEPTIDASE (Porphyromonasgingivalis) |
PF10459(Peptidase_S46) | 5 | TYR A 464GLY A 400ILE A 402ARG A 393LEU A 538 | None | 1.24A | 4kotA-5jwfA:undetectable | 4kotA-5jwfA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lun | 2-OXOGLUTARATE-DEPENDENTETHYLENE/SUCCINATE-FORMING ENZYME (Pseudomonassavastanoi) |
PF03171(2OG-FeII_Oxy)PF14226(DIOX_N) | 5 | PHE A 283ARG A 321GLY A 77TYR A 126LEU A 173 | ARG A 403 ( 4.2A)NoneNoneNoneOGA A 402 (-4.5A) | 1.50A | 4kotA-5lunA:undetectable | 4kotA-5lunA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tdx | ANCESTRALHYDROXYNITRILE LYASE1 (syntheticconstruct) |
no annotation | 5 | PRO A 108GLY A 82ILE A 12ARG A 186LEU A 183 | None | 1.28A | 4kotA-5tdxA:undetectable | 4kotA-5tdxA:19.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vdb | ACETYLTRANSFERASEPA4794 (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 6 | ARG A 49TYR A 68GLY A 79ASN A 66ILE A 115TYR A 128 | 93M A 207 ( 4.3A)93M A 207 (-3.4A)93M A 207 (-3.5A)NoneNone93M A 207 (-4.9A) | 1.30A | 4kotA-5vdbA:32.0 | 4kotA-5vdbA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vdb | ACETYLTRANSFERASEPA4794 (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 12 | PHE A 27CYH A 29PRO A 31ARG A 49TYR A 68GLY A 79ASN A 80ILE A 115PHE A 118TYR A 128ARG A 141LEU A 151 | None93M A 207 (-4.6A)93M A 207 (-4.0A)93M A 207 ( 4.3A)93M A 207 (-3.4A)93M A 207 (-3.5A)NoneNoneNone93M A 207 (-4.9A)SO4 A 206 (-3.0A)93M A 207 (-4.6A) | 0.29A | 4kotA-5vdbA:32.0 | 4kotA-5vdbA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vdb | ACETYLTRANSFERASEPA4794 (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 5 | PHE A 118CYH A 29PRO A 31ARG A 49ASN A 80 | None93M A 207 (-4.6A)93M A 207 (-4.0A)93M A 207 ( 4.3A)None | 1.32A | 4kotA-5vdbA:32.0 | 4kotA-5vdbA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bb4 | MOUSE MONOCLONALANTIBODY C5.2 FABHEAVY CHAINMOUSE MONOCLONALANTIBODY C5.2 FABLIGHT CHAIN (Mus musculus) |
no annotation | 5 | PHE L 36PRO L 44GLY L 41PHE L 87LEU H 45 | None | 1.16A | 4kotA-6bb4L:undetectable | 4kotA-6bb4L:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bo6 | - (-) |
no annotation | 5 | PHE A 549GLY A 506PHE A 514ARG A 480LEU A 478 | None | 1.12A | 4kotA-6bo6A:undetectable | 4kotA-6bo6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cw5 | RIBOKINASE (Cryptococcusneoformans) |
no annotation | 5 | PHE A 162PRO A 164GLY A 189ASN A 187LEU A 173 | None | 1.00A | 4kotA-6cw5A:undetectable | 4kotA-6cw5A:19.64 |