SIMILAR PATTERNS OF AMINO ACIDS FOR 4KOS_A_4KOA201_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ciy | CRYIA(A) (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | TYR A 250ASN A 249ILE A 243PHE A 45LEU A 60 | None | 1.43A | 4kosA-1ciyA:1.1 | 4kosA-1ciyA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1edg | ENDOGLUCANASE A ([Clostridium]cellulolyticum) |
PF00150(Cellulase) | 5 | PRO A 18GLY A 22ASN A 24ILE A 250ARG A 299 | None | 1.23A | 4kosA-1edgA:0.0 | 4kosA-1edgA:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ffv | CUTS, IRON-SULFURPROTEIN OF CARBONMONOXIDEDEHYDROGENASE (Hydrogenophagapseudoflava) |
PF00111(Fer2)PF01799(Fer2_2) | 5 | CYH A 104PRO A 106GLY A 48ASN A 134ILE A 40 | FES A1907 (-2.2A)NoneFES A1908 (-3.7A)NoneFES A1908 ( 4.4A) | 1.45A | 4kosA-1ffvA:0.0 | 4kosA-1ffvA:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iyx | ENOLASE (Enterococcushirae) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | GLY A 392ASN A 147MET A 146ILE A 389LEU A 337 | None | 1.06A | 4kosA-1iyxA:0.0 | 4kosA-1iyxA:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jny | ELONGATION FACTOR1-ALPHA (Sulfolobussolfataricus) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 5 | PRO A 195GLY A 18ASN A 152PHE A 55LEU A 59 | GDP A 500 (-4.3A)GDP A 500 (-3.2A)GDP A 500 (-3.2A)NoneNone | 1.46A | 4kosA-1jnyA:undetectable | 4kosA-1jnyA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k1d | D-HYDANTOINASE (Geobacillusstearothermophilus) |
PF01979(Amidohydro_1) | 5 | CYH A 48PRO A 398GLY A 8ILE A 10LEU A 361 | None | 1.37A | 4kosA-1k1dA:0.0 | 4kosA-1k1dA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n60 | CARBON MONOXIDEDEHYDROGENASE SMALLCHAIN (Oligotrophacarboxidovorans) |
PF00111(Fer2)PF01799(Fer2_2) | 5 | CYH A 105PRO A 107GLY A 48ASN A 135ILE A 40 | FES A4907 (-2.2A)NoneFES A4908 (-3.9A)NoneFES A4908 (-4.4A) | 1.45A | 4kosA-1n60A:undetectable | 4kosA-1n60A:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nw5 | MODIFICATIONMETHYLASE RSRI (Rhodobactersphaeroides) |
PF01555(N6_N4_Mtase) | 5 | GLY A 106ILE A 159PHE A 162ARG A 127LEU A 134 | None | 1.17A | 4kosA-1nw5A:0.0 | 4kosA-1nw5A:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1px8 | BETA-XYLOSIDASE (Thermoanaerobacteriumsaccharolyticum) |
PF01229(Glyco_hydro_39) | 5 | CYH A 58ARG A 65GLY A 62ILE A 82LEU A 31 | None | 1.48A | 4kosA-1px8A:1.0 | 4kosA-1px8A:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tu7 | GLUTATHIONES-TRANSFERASE 2 (Onchocercavolvulus) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | ARG A 95GLY A 64ILE A 60ARG A 18LEU A 5 | GSH A1001 (-3.6A)NoneNoneNoneNone | 1.36A | 4kosA-1tu7A:undetectable | 4kosA-1tu7A:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tww | DHPS,DIHYDROPTEROATESYNTHASE (Bacillusanthracis) |
PF00809(Pterin_bind) | 5 | PRO A 212GLY A 249ASN A 207ILE A 246PHE A 252 | None | 1.38A | 4kosA-1twwA:undetectable | 4kosA-1twwA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tww | DHPS,DIHYDROPTEROATESYNTHASE (Bacillusanthracis) |
PF00809(Pterin_bind) | 5 | PRO A 212GLY A 249ILE A 246PHE A 252LEU A 21 | None | 1.36A | 4kosA-1twwA:undetectable | 4kosA-1twwA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uag | UDP-N-ACETYLMURAMOYL-L-ALANINE/:D-GLUTAMATE LIGASE (Escherichiacoli) |
PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | GLY A 111ASN A 178ILE A 201TYR A 202LEU A 278 | KCX A 198 ( 3.9A)NoneKCX A 198 ( 3.6A)NoneNone | 1.23A | 4kosA-1uagA:undetectable | 4kosA-1uagA:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v0f | ENDO-ALPHA-SIALIDASE (Enterobacteriaphage K1F) |
PF12217(End_beta_propel)PF12218(End_N_terminal)PF12219(End_tail_spike) | 5 | PRO A 372TYR A 324GLY A 346ASN A 326MET A 345 | PRO A 372 ( 1.1A)TYR A 324 ( 1.3A)GLY A 346 ( 0.0A)ASN A 326 ( 0.6A)MET A 345 ( 0.0A) | 1.34A | 4kosA-1v0fA:undetectable | 4kosA-1v0fA:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vjg | PUTATIVE LIPASE FROMTHE G-D-S-L FAMILY (Nostoc sp. PCC7120) |
PF13472(Lipase_GDSL_2) | 5 | CYH A 27PRO A 25ARG A 33TYR A 188GLY A 29 | None | 1.40A | 4kosA-1vjgA:0.8 | 4kosA-1vjgA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wza | ALPHA-AMYLASE A (Halothermothrixorenii) |
PF00128(Alpha-amylase) | 5 | TYR A 34GLY A 32ASN A 77ILE A 321PHE A 28 | None | 1.19A | 4kosA-1wzaA:undetectable | 4kosA-1wzaA:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fym | ENOLASE (Escherichiacoli) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | GLY A 394ASN A 151MET A 150ILE A 391LEU A 339 | None | 1.09A | 4kosA-2fymA:undetectable | 4kosA-2fymA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n3w | 26S PROTEASOMEREGULATORY SUBUNITRPN1 (Saccharomycescerevisiae) |
PF01851(PC_rep) | 5 | CYH A 538GLY A 540ILE A 546PHE A 534LEU A 506 | None | 1.41A | 4kosA-2n3wA:undetectable | 4kosA-2n3wA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vrk | ALPHA-L-ARABINOFURANOSIDASE (Thermobacillusxylanilyticus) |
PF06964(Alpha-L-AF_C) | 5 | TYR A 193ASN A 177ILE A 211TYR A 125LEU A 200 | None | 1.41A | 4kosA-2vrkA:undetectable | 4kosA-2vrkA:15.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2q | 6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE (Arthrobactersp. KI72) |
PF01425(Amidase) | 5 | PRO A 427ARG A 176PHE A 308ARG A 306LEU A 309 | None | 1.37A | 4kosA-3a2qA:undetectable | 4kosA-3a2qA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c41 | AMINO ACID ABCTRANSPORTER (ARTP) (Geobacillusstearothermophilus) |
PF00005(ABC_tran) | 5 | PRO J 35GLY J 39ILE J 20PHE J 208ARG J 231 | NoneANP J 601 (-3.2A)NoneNoneNone | 1.13A | 4kosA-3c41J:undetectable | 4kosA-3c41J:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d1c | FLAVIN-CONTAININGPUTATIVEMONOOXYGENASE (Staphylococcusaureus) |
PF13738(Pyr_redox_3) | 5 | PRO A 75ASN A 59ILE A 20TYR A 100LEU A 93 | None | 1.23A | 4kosA-3d1cA:undetectable | 4kosA-3d1cA:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e03 | SHORT CHAINDEHYDROGENASE (Xanthomonascampestris) |
PF13561(adh_short_C2) | 5 | ASN A 98ILE A 102TYR A 165ARG A 73LEU A 117 | None | 1.47A | 4kosA-3e03A:0.7 | 4kosA-3e03A:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ehc | SNOAL-LIKEPOLYKETIDE CYCLASE (Agrobacteriumfabrum) |
PF07366(SnoaL) | 5 | ARG A 36ILE A 110TYR A 103ARG A 44LEU A 23 | SO4 A 130 (-3.7A)NoneNoneNoneNone | 1.38A | 4kosA-3ehcA:undetectable | 4kosA-3ehcA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fvb | BACTERIOFERRITIN (Brucellaabortus) |
PF00210(Ferritin) | 5 | PRO A 76ARG A 78GLY A 93PHE A 16TYR A 101 | None | 1.29A | 4kosA-3fvbA:undetectable | 4kosA-3fvbA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iie | 1-DEOXY-D-XYLULOSE5-PHOSPHATEREDUCTOISOMERASE (Yersiniapseudotuberculosis) |
PF02670(DXP_reductoisom)PF08436(DXP_redisom_C)PF13288(DXPR_C) | 5 | ASN A 227MET A 226ILE A 356ARG A 216LEU A 347 | MG A 501 ( 4.1A)NoneNoneNoneNone | 1.37A | 4kosA-3iieA:undetectable | 4kosA-3iieA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ik4 | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Herpetosiphonaurantiacus) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | PRO A 324GLY A 295ILE A 293PHE A 336LEU A 343 | None | 1.05A | 4kosA-3ik4A:undetectable | 4kosA-3ik4A:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3irz | URO-ADHERENCE FACTORA (Staphylococcussaprophyticus) |
PF17210(SdrD_B) | 5 | PRO A 729GLY A 473ILE A 476TYR A 495LEU A 734 | None | 1.28A | 4kosA-3irzA:undetectable | 4kosA-3irzA:17.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kkw | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 6 | ARG A 49TYR A 68GLY A 79ASN A 66ILE A 115TYR A 128 | EDO A 175 ( 3.0A)EDO A 175 (-3.6A)EDO A 175 ( 3.6A)NoneNoneEDO A 176 ( 4.8A) | 1.26A | 4kosA-3kkwA:31.8 | 4kosA-3kkwA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kkw | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 5 | CYH A 29PRO A 31ARG A 49ASN A 80PHE A 27 | EDO A 163 ( 3.5A)EDO A 175 (-4.3A)EDO A 175 ( 3.0A)EDO A 175 ( 4.3A)EDO A 171 ( 4.5A) | 1.41A | 4kosA-3kkwA:31.8 | 4kosA-3kkwA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kkw | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 12 | CYH A 29PRO A 31ARG A 49TYR A 68GLY A 79ASN A 80MET A 81ILE A 115PHE A 118TYR A 128ARG A 141LEU A 151 | EDO A 163 ( 3.5A)EDO A 175 (-4.3A)EDO A 175 ( 3.0A)EDO A 175 (-3.6A)EDO A 175 ( 3.6A)EDO A 175 ( 4.3A)EDO A 174 ( 4.8A)NoneNoneEDO A 176 ( 4.8A)SO4 A 161 (-3.9A)None | 0.44A | 4kosA-3kkwA:31.8 | 4kosA-3kkwA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7i | TEICHOIC ACIDBIOSYNTHESIS PROTEINF (Staphylococcusepidermidis) |
PF04464(Glyphos_transf) | 5 | PRO A 665ILE A 564PHE A 638TYR A 543LEU A 677 | None | 1.50A | 4kosA-3l7iA:undetectable | 4kosA-3l7iA:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mm5 | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT ALPHA (Archaeoglobusfulgidus) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | PRO A 102GLY A 134ILE A 137PHE A 160LEU A 115 | NoneSRM A 580 (-4.1A)NoneNoneNone | 1.06A | 4kosA-3mm5A:undetectable | 4kosA-3mm5A:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rh2 | HYPOTHETICALTETR-LIKETRANSCRIPTIONALREGULATOR (Shewanellaamazonensis) |
PF00440(TetR_N)PF13972(TetR) | 5 | TYR A 96GLY A 156MET A 153PHE A 65LEU A 61 | NoneUNL A 301 ( 4.7A)NoneUNL A 301 ( 4.2A)None | 1.47A | 4kosA-3rh2A:0.9 | 4kosA-3rh2A:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rw9 | SPERMIDINE SYNTHASE (Homo sapiens) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | CYH A 205TYR A 233GLY A 207ILE A 246TYR A 79 | NoneNoneNoneNoneDSH A 303 ( 4.9A) | 1.29A | 4kosA-3rw9A:undetectable | 4kosA-3rw9A:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vte | TETRAHYDROCANNABINOLIC ACID SYNTHASE (Cannabis sativa) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | GLY A 188ASN A 483ILE A 431PHE A 511LEU A 518 | NoneFAD A 607 (-3.3A)NoneNoneNone | 1.12A | 4kosA-3vteA:undetectable | 4kosA-3vteA:14.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wp5 | CDBFV (Neocallimastixpatriciarum) |
PF00457(Glyco_hydro_11) | 5 | ARG A 61TYR A 100GLY A 101PHE A 159ARG A 148 | None | 1.40A | 4kosA-3wp5A:undetectable | 4kosA-3wp5A:16.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a3r | ENOLASE (Bacillussubtilis) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | GLY A 392ASN A 148MET A 147ILE A 389LEU A 337 | None | 1.06A | 4kosA-4a3rA:undetectable | 4kosA-4a3rA:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c51 | CATALASE-PEROXIDASE (Mycobacteriumtuberculosis) |
PF00141(peroxidase) | 5 | PRO A 432TYR A 426GLY A 184ILE A 416PHE A 181 | None | 0.91A | 4kosA-4c51A:undetectable | 4kosA-4c51A:12.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cok | PYRUVATEDECARBOXYLASE (Gluconacetobacterdiazotrophicus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | PRO A 426TYR A 60GLY A 420ASN A 421ILE A 45 | None | 1.28A | 4kosA-4cokA:undetectable | 4kosA-4cokA:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rk9 | CARBOHYDRATE ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN MSME (Bacilluslicheniformis) |
PF01547(SBP_bac_1) | 5 | GLY A 143ILE A 303PHE A 196TYR A 372LEU A 200 | NoneNoneNoneGLA A 503 (-3.6A)None | 1.23A | 4kosA-4rk9A:undetectable | 4kosA-4rk9A:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqv | ALGM1 (Sphingomonassp.) |
PF00528(BPD_transp_1) | 5 | PRO A 112GLY A 104ILE A 253PHE A 111LEU A 246 | None | 1.47A | 4kosA-4tqvA:undetectable | 4kosA-4tqvA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5avo | HOMOSERINEDEHYDROGENASE (Sulfurisphaeratokodaii) |
PF00742(Homoserine_dh)PF03447(NAD_binding_3) | 5 | ARG A 140GLY A 124ILE A 97PHE A 109TYR A 87 | None | 1.38A | 4kosA-5avoA:undetectable | 4kosA-5avoA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eb5 | HNL ISOENZYME 5 (Prunus dulcis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | PRO A 352TYR A 349GLY A 434ILE A 304PHE A 356 | None | 1.24A | 4kosA-5eb5A:undetectable | 4kosA-5eb5A:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5es6 | LINEAR GRAMICIDINSYNTHASE SUBUNIT A (Brevibacillusparabrevis) |
PF00501(AMP-binding)PF00551(Formyl_trans_N) | 5 | CYH A 486ARG A 562GLY A 539TYR A 347ARG A 510 | None | 1.45A | 4kosA-5es6A:undetectable | 4kosA-5es6A:13.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5es9 | LINEAR GRAMICIDINSYNTHETASE SUBUNIT A (Brevibacillusparabrevis) |
PF00501(AMP-binding)PF00550(PP-binding)PF00551(Formyl_trans_N)PF13193(AMP-binding_C) | 5 | CYH A 486ARG A 562GLY A 539TYR A 347ARG A 510 | None | 1.47A | 4kosA-5es9A:undetectable | 4kosA-5es9A:13.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fn4 | NICASTRIN (Homo sapiens) |
PF05450(Nicastrin) | 5 | ARG A 117TYR A 94GLY A 89PHE A 210LEU A 212 | None | 1.02A | 4kosA-5fn4A:undetectable | 4kosA-5fn4A:12.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fxe | EUGENOL OXIDASE (Rhodococcusjostii) |
PF01565(FAD_binding_4)PF02913(FAD-oxidase_C) | 5 | PRO A 6ARG A 520GLY A 77ILE A 72PHE A 14 | None | 1.44A | 4kosA-5fxeA:3.3 | 4kosA-5fxeA:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw7 | GLUCOSIDASE YGJK (Escherichiacoli) |
PF01204(Trehalase) | 5 | PRO A 31GLY A 55PHE A 33TYR A 195LEU A 59 | None | 1.30A | 4kosA-5gw7A:undetectable | 4kosA-5gw7A:13.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j04 | ENOLASE (Synechococcuselongatus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | GLY A 392ASN A 152MET A 151ILE A 389LEU A 337 | None | 1.03A | 4kosA-5j04A:undetectable | 4kosA-5j04A:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jnf | LINEAR GRAMICIDINSYNTHASE SUBUNIT A (Brevibacillusparabrevis) |
no annotation | 5 | CYH C 486ARG C 562GLY C 539TYR C 347ARG C 510 | None | 1.47A | 4kosA-5jnfC:undetectable | 4kosA-5jnfC:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jwf | ASP/GLU-SPECIFICDIPEPTIDYL-PEPTIDASE (Porphyromonasgingivalis) |
PF10459(Peptidase_S46) | 5 | TYR A 464GLY A 400ILE A 402ARG A 393LEU A 538 | None | 1.20A | 4kosA-5jwfA:undetectable | 4kosA-5jwfA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5olk | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE,BETA SUBUNIT 1 (Leeuwenhoekiellablandensis) |
no annotation | 5 | ASN A 278MET A 283ILE A 159PHE A 140LEU A 210 | None | 1.39A | 4kosA-5olkA:0.5 | 4kosA-5olkA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5txr | 5-AMINOLEVULINATESYNTHASE,MITOCHONDRIAL (Saccharomycescerevisiae) |
no annotation | 5 | GLY B 155ASN B 157ILE B 153PHE B 363ARG B 357 | None | 1.42A | 4kosA-5txrB:undetectable | 4kosA-5txrB:16.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vdb | ACETYLTRANSFERASEPA4794 (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 6 | ARG A 49TYR A 68GLY A 79ASN A 66ILE A 115TYR A 128 | 93M A 207 ( 4.3A)93M A 207 (-3.4A)93M A 207 (-3.5A)NoneNone93M A 207 (-4.9A) | 1.25A | 4kosA-5vdbA:31.8 | 4kosA-5vdbA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vdb | ACETYLTRANSFERASEPA4794 (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 12 | CYH A 29PRO A 31ARG A 49TYR A 68GLY A 79ASN A 80MET A 81ILE A 115PHE A 118TYR A 128ARG A 141LEU A 151 | 93M A 207 (-4.6A)93M A 207 (-4.0A)93M A 207 ( 4.3A)93M A 207 (-3.4A)93M A 207 (-3.5A)None93M A 207 (-4.9A)NoneNone93M A 207 (-4.9A)SO4 A 206 (-3.0A)93M A 207 (-4.6A) | 0.33A | 4kosA-5vdbA:31.8 | 4kosA-5vdbA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y4j | XYLOSE ISOMERASE (Streptomycesrubiginosus) |
PF01261(AP_endonuc_2) | 5 | CYH A 306GLY A 261ILE A 312PHE A 11ARG A 284 | None | 1.49A | 4kosA-5y4jA:undetectable | 4kosA-5y4jA:18.23 |