SIMILAR PATTERNS OF AMINO ACIDS FOR 4KOE_H_TR6H101_1

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1c7t	BETA-N-ACETYLHEXOSAM INIDASE (Serratia marcescens)	PF00728 (Glyco_hydro_20) PF02838 (Glyco_hydro_20b) PF03173 (CHB_HEX) PF03174 (CHB_HEX_C)	4	SER A 500 GLY A 619 ASP A 618 GLY A 537	None	0.84A	4koeA-1c7tA: undetectable 4koeB-1c7tA: undetectable 4koeD-1c7tA: undetectable	4koeA-1c7tA: 20.55 4koeB-1c7tA: 20.55 4koeD-1c7tA: 16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1csj	HEPATITIS C VIRUS RNA POLYMERASE (NS5B) (Hepacivirus C)	PF00998 (RdRP_3)	4	SER A 121 GLY A 104 ASP A 107 GLY A 102	None	0.95A	4koeA-1csjA: undetectable 4koeB-1csjA: 3.9 4koeD-1csjA: undetectable	4koeA-1csjA: 21.90 4koeB-1csjA: 21.90 4koeD-1csjA: 18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1d02	TYPE II RESTRICTION ENZYME MUNI (Mycoplasma)	PF11407 (RestrictionMunI)	4	SER A 122 GLY A 104 ASP A 159 GLY A 116	None	0.94A	4koeA-1d02A: undetectable 4koeB-1d02A: undetectable 4koeD-1d02A: undetectable	4koeA-1d02A: 17.62 4koeB-1d02A: 17.62 4koeD-1d02A: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1dpp	DIPEPTIDE BINDING PROTEIN (Escherichia coli)	PF00496 (SBP_bac_5)	4	SER A 156 GLY A 497 GLY A  22 GLU A   8	None None LEU  A1002 (-3.8A) None	0.84A	4koeA-1dppA: 4.1 4koeB-1dppA: 4.2 4koeD-1dppA: undetectable	4koeA-1dppA: 22.70 4koeB-1dppA: 22.70 4koeD-1dppA: 19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1dqw	OROTIDINE 5'-PHOSPHATE DECARBOXYLASE (Saccharomyces cerevisiae)	PF00215 (OMPdecase)	4	GLY A 205 ASP A 207 GLY A 236 GLU A 247	None	0.93A	4koeA-1dqwA: undetectable 4koeB-1dqwA: undetectable 4koeD-1dqwA: undetectable	4koeA-1dqwA: 21.16 4koeB-1dqwA: 21.16 4koeD-1dqwA: 22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ex0	COAGULATION FACTOR XIII A CHAIN (Homo sapiens)	PF00868 (Transglut_N) PF00927 (Transglut_C) PF01841 (Transglut_core)	4	GLY A 473 ASP A 472 GLY A 470 GLU A 203	None	0.75A	4koeA-1ex0A: undetectable 4koeB-1ex0A: undetectable 4koeD-1ex0A: undetectable	4koeA-1ex0A: 21.26 4koeB-1ex0A: 21.26 4koeD-1ex0A: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1gq4	EZRIN-RADIXIN-MOESIN BINDING PHOSPHOPROTEIN-50 (Homo sapiens)	PF00595 (PDZ)	4	ARG A  80 GLY A  23 GLY A  25 GLU A  43	None	0.82A	4koeA-1gq4A: undetectable 4koeB-1gq4A: undetectable 4koeD-1gq4A: undetectable	4koeA-1gq4A: 12.27 4koeB-1gq4A: 12.27 4koeD-1gq4A: 14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1gt9	KUMAMOLYSIN (Bacillus subtilis)	PF00082 (Peptidase_S8)	4	SER 1 278 GLY 1  36 ASP 1  76 GLY 1  34	None	0.92A	4koeA-1gt91: undetectable 4koeB-1gt91: undetectable 4koeD-1gt91: undetectable	4koeA-1gt91: 20.52 4koeB-1gt91: 20.52 4koeD-1gt91: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1k32	TRICORN PROTEASE (Thermoplasma acidophilum)	PF03572 (Peptidase_S41) PF07676 (PD40) PF14684 (Tricorn_C1) PF14685 (Tricorn_PDZ)	4	GLY A1003 ASP A1002 GLY A 751 GLU A 749	None	0.93A	4koeA-1k32A: undetectable 4koeB-1k32A: undetectable 4koeD-1k32A: undetectable	4koeA-1k32A: 19.58 4koeB-1k32A: 19.58 4koeD-1k32A: 13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1pie	GALACTOKINASE (Lactococcus lactis)	PF00288 (GHMP_kinases_N) PF08544 (GHMP_kinases_C) PF10509 (GalKase_gal_bdg)	4	ARG A 236 GLY A 349 GLY A 324 GLU A 326	None	0.89A	4koeA-1pieA: undetectable 4koeB-1pieA: 2.6 4koeD-1pieA: undetectable	4koeA-1pieA: 23.79 4koeB-1pieA: 23.79 4koeD-1pieA: 20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1r6v	SUBTILISIN-LIKE SERINE PROTEASE (Fervidobacterium pennivorans)	PF00082 (Peptidase_S8)	4	GLY A 172 ASP A 170 GLY A 205 GLU A 368	None	0.93A	4koeA-1r6vA: undetectable 4koeB-1r6vA: 3.5 4koeD-1r6vA: undetectable	4koeA-1r6vA: 21.93 4koeB-1r6vA: 21.93 4koeD-1r6vA: 18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1to6	GLYCERATE KINASE (Neisseria meningitidis)	PF02595 (Gly_kinase)	4	SER A 293 GLY A  42 GLY A  44 GLU A  87	None	0.87A	4koeA-1to6A: undetectable 4koeB-1to6A: undetectable 4koeD-1to6A: 4.8	4koeA-1to6A: 21.51 4koeB-1to6A: 21.51 4koeD-1to6A: 22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1v1p	EXOTOXIN 1 (Staphylococcus aureus)	PF02876 (Stap_Strp_tox_C) PF09199 (SSL_OB)	4	GLY A 193 ASP A 194 GLY A  68 GLU A  72	None	0.88A	4koeA-1v1pA: undetectable 4koeB-1v1pA: undetectable 4koeD-1v1pA: undetectable	4koeA-1v1pA: 21.22 4koeB-1v1pA: 21.22 4koeD-1v1pA: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1vjg	PUTATIVE LIPASE FROM THE G-D-S-L FAMILY (Nostoc sp. PCC 7120)	PF13472 (Lipase_GDSL_2)	4	SER A  83 GLY A  23 ASP A  24 GLU A 174	None	0.87A	4koeA-1vjgA: undetectable 4koeB-1vjgA: undetectable 4koeD-1vjgA: 3.4	4koeA-1vjgA: 17.85 4koeB-1vjgA: 17.85 4koeD-1vjgA: 22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1xvy	SFUA (Yersinia enterocolitica)	PF13343 (SBP_bac_6)	4	GLY A  21 ASP A  25 GLY A 254 GLU A 256	None	0.93A	4koeA-1xvyA: undetectable 4koeB-1xvyA: undetectable 4koeD-1xvyA: undetectable	4koeA-1xvyA: 23.01 4koeB-1xvyA: 23.01 4koeD-1xvyA: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2agm	POLY(BETA-D-MANNURON ATE) C5 EPIMERASE 4 (Azotobacter vinelandii)	PF00353 (HemolysinCabind) PF08548 (Peptidase_M10_C)	4	GLY A 131 ASP A 130 GLY A 108 GLU A 107	None	0.82A	4koeA-2agmA: undetectable 4koeB-2agmA: undetectable 4koeD-2agmA: undetectable	4koeA-2agmA: 16.29 4koeB-2agmA: 16.29 4koeD-2agmA: 25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2d3r	LECTIN ALPHA CHAIN (Cratylia argentea)	PF00139 (Lectin_legB)	4	ARG A 171 SER A 218 GLY A 225 GLY A 223	None	0.96A	4koeA-2d3rA: undetectable 4koeB-2d3rA: undetectable 4koeD-2d3rA: undetectable	4koeA-2d3rA: 17.55 4koeB-2d3rA: 17.55 4koeD-2d3rA: 19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ep5	350AA LONG HYPOTHETICAL ASPARTATE-SEMIALDEHY DE DEHYDROGENASE (Sulfurisphaera tokodaii)	PF01118 (Semialdhyde_dh) PF02774 (Semialdhyde_dhC)	4	SER A 157 GLY A 305 ASP A 327 GLY A 335	None	0.95A	4koeA-2ep5A: undetectable 4koeB-2ep5A: undetectable 4koeD-2ep5A: 2.2	4koeA-2ep5A: 22.09 4koeB-2ep5A: 22.09 4koeD-2ep5A: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2fep	CATABOLITE CONTROL PROTEIN A (Bacillus subtilis)	PF13377 (Peripla_BP_3)	4	GLY A 220 ASP A 221 GLY A 227 GLU A 229	None	0.85A	4koeA-2fepA: undetectable 4koeB-2fepA: undetectable 4koeD-2fepA: 3.4	4koeA-2fepA: 21.10 4koeB-2fepA: 21.10 4koeD-2fepA: 25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2gup	ROK FAMILY PROTEIN (Streptococcus pneumoniae)	PF00480 (ROK)	4	SER A 235 ASP A 100 GLY A 129 GLU A 147	None TRS  A 293 (-2.8A) None None	0.69A	4koeA-2gupA: undetectable 4koeB-2gupA: undetectable 4koeD-2gupA: 2.5	4koeA-2gupA: 20.76 4koeB-2gupA: 20.76 4koeD-2gupA: 18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2i0o	SER/THR PHOSPHATASE (Anopheles gambiae)	PF00481 (PP2C)	4	SER A 426 GLY A 478 ASP A 479 GLU A  63	None	0.95A	4koeA-2i0oA: undetectable 4koeB-2i0oA: undetectable 4koeD-2i0oA: undetectable	4koeA-2i0oA: 22.16 4koeB-2i0oA: 22.16 4koeD-2i0oA: 19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2nv2	PYRIDOXAL BIOSYNTHESIS LYASE PDXS (Bacillus subtilis)	PF01680 (SOR_SNZ)	4	ARG A 147 SER A 104 GLY A 214 GLY A 153	None	0.86A	4koeA-2nv2A: undetectable 4koeB-2nv2A: undetectable 4koeD-2nv2A: undetectable	4koeA-2nv2A: 20.85 4koeB-2nv2A: 20.85 4koeD-2nv2A: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2nxf	PUTATIVE DIMETAL PHOSPHATASE (Danio rerio)	PF00149 (Metallophos)	4	GLY A 269 ASP A 266 GLY A 285 GLU A 288	None	0.85A	4koeA-2nxfA: undetectable 4koeB-2nxfA: undetectable 4koeD-2nxfA: undetectable	4koeA-2nxfA: 22.56 4koeB-2nxfA: 22.56 4koeD-2nxfA: 18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2o8e	DNA MISMATCH REPAIR PROTEIN MSH6 (Homo sapiens)	PF00488 (MutS_V) PF01624 (MutS_I) PF05188 (MutS_II) PF05190 (MutS_IV) PF05192 (MutS_III)	4	ARG B 581 SER B 714 GLY B 557 GLY B 571	None	0.91A	4koeA-2o8eB: undetectable 4koeB-2o8eB: undetectable 4koeD-2o8eB: undetectable	4koeA-2o8eB: 18.70 4koeB-2o8eB: 18.70 4koeD-2o8eB: 13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ogs	THERMOSTABLE CARBOXYLESTERASE EST50 (Geobacillus stearothermophilus)	PF00135 (COesterase)	4	GLY A  84 ASP A  83 GLY A  58 GLU A  78	GLY  A  84 ( 0.0A) ASP  A  83 ( 0.6A) GLY  A  58 ( 0.0A) GLU  A  78 ( 0.6A)	0.96A	4koeA-2ogsA: undetectable 4koeB-2ogsA: undetectable 4koeD-2ogsA: 2.5	4koeA-2ogsA: 23.33 4koeB-2ogsA: 23.33 4koeD-2ogsA: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2qzx	CANDIDAPEPSIN-5 (Candida albicans)	PF00026 (Asp)	4	SER A  88 GLY A 125 ASP A  37 GLY A  34	None	0.95A	4koeA-2qzxA: undetectable 4koeB-2qzxA: undetectable 4koeD-2qzxA: undetectable	4koeA-2qzxA: 23.11 4koeB-2qzxA: 23.11 4koeD-2qzxA: 23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2vn1	70 KDA PEPTIDYLPROLYL ISOMERASE (Plasmodium falciparum)	PF00254 (FKBP_C)	4	SER A  50 GLY A 100 GLY A 105 GLU A 104	None	0.96A	4koeA-2vn1A: undetectable 4koeB-2vn1A: undetectable 4koeD-2vn1A: undetectable	4koeA-2vn1A: 14.66 4koeB-2vn1A: 14.66 4koeD-2vn1A: 16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2wzs	PUTATIVE ALPHA-1,2-MANNOSIDAS E (Bacteroides thetaiotaomicron)	PF07971 (Glyco_hydro_92)	4	ARG A 351 ASP A 644 GLY A 600 GLU A 588	None CA  A 800 ( 2.8A) None None	0.87A	4koeA-2wzsA: undetectable 4koeB-2wzsA: 2.6 4koeD-2wzsA: undetectable	4koeA-2wzsA: 21.49 4koeB-2wzsA: 21.49 4koeD-2wzsA: 15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2xkk	TOPOISOMERASE IV (Acinetobacter baumannii)	PF00521 (DNA_topoisoIV) PF00986 (DNA_gyraseB_C) PF01751 (Toprim)	4	GLY A 396 ASP A 397 GLY A 419 GLU A 437	None	0.69A	4koeA-2xkkA: 48.2 4koeB-2xkkA: 48.1 4koeD-2xkkA: 24.5	4koeA-2xkkA: 27.59 4koeB-2xkkA: 27.59 4koeD-2xkkA: 17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2y4y	PILP PROTEIN (Pseudomonas aeruginosa)	PF04351 (PilP)	4	ARG A 164 GLY A 138 ASP A 137 GLY A 134	None	0.78A	4koeA-2y4yA: undetectable 4koeB-2y4yA: undetectable 4koeD-2y4yA: undetectable	4koeA-2y4yA: 11.91 4koeB-2y4yA: 11.91 4koeD-2y4yA: 16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2yp1	AROMATIC PEROXYGENASE (Agrocybe aegerita)	PF01328 (Peroxidase_2)	4	SER A 271 GLY A 123 ASP A 124 GLY A 119	None HEM  A 350 ( 3.8A) None None	0.78A	4koeA-2yp1A: undetectable 4koeB-2yp1A: undetectable 4koeD-2yp1A: undetectable	4koeA-2yp1A: 20.56 4koeB-2yp1A: 20.56 4koeD-2yp1A: 20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2yp1	AROMATIC PEROXYGENASE (Agrocybe aegerita)	PF01328 (Peroxidase_2)	4	SER A 272 GLY A 123 ASP A 124 GLY A 119	None HEM  A 350 ( 3.8A) None None	0.92A	4koeA-2yp1A: undetectable 4koeB-2yp1A: undetectable 4koeD-2yp1A: undetectable	4koeA-2yp1A: 20.56 4koeB-2yp1A: 20.56 4koeD-2yp1A: 20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3b1b	CARBONIC ANHYDRASE 1 (Chlamydomonas reinhardtii)	PF00194 (Carb_anhydrase)	4	SER A 265 GLY A  37 ASP A  38 GLY A  56	None	0.90A	4koeA-3b1bA: undetectable 4koeB-3b1bA: undetectable 4koeD-3b1bA: undetectable	4koeA-3b1bA: 21.10 4koeB-3b1bA: 21.10 4koeD-3b1bA: 19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3bt3	GLYOXALASE-RELATED ENZYME, ARAC TYPE (Lachnoclostridium phytofermentans)	no annotation	4	GLY A 177 ASP A 178 GLY A 175 GLU A 174	None	0.89A	4koeA-3bt3A: undetectable 4koeB-3bt3A: undetectable 4koeD-3bt3A: undetectable	4koeA-3bt3A: 15.30 4koeB-3bt3A: 15.30 4koeD-3bt3A: 19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3fou	QUINOL-CYTOCHROME C REDUCTASE, RIESKE IRON-SULFUR SUBUNIT (Thermus thermophilus)	PF00355 (Rieske)	4	GLY A  55 ASP A  56 GLY A 191 GLU A 192	None	0.85A	4koeA-3fouA: undetectable 4koeB-3fouA: undetectable 4koeD-3fouA: undetectable	4koeA-3fouA: 15.23 4koeB-3fouA: 15.23 4koeD-3fouA: 23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3gq9	PRENECK APPENDAGE PROTEIN (Bacillus virus phi29)	PF11962 (Peptidase_G2) PF12708 (Pectate_lyase_3)	4	SER A 456 GLY A 531 ASP A 506 GLY A 503	None	0.71A	4koeA-3gq9A: undetectable 4koeB-3gq9A: undetectable 4koeD-3gq9A: undetectable	4koeA-3gq9A: 21.23 4koeB-3gq9A: 21.23 4koeD-3gq9A: 17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3gxa	OUTER MEMBRANE LIPOPROTEIN GNA1946 (Neisseria meningitidis)	PF03180 (Lipoprotein_9)	4	SER A 203 GLY A 214 GLY A 127 GLU A 231	None	0.94A	4koeA-3gxaA: undetectable 4koeB-3gxaA: undetectable 4koeD-3gxaA: undetectable	4koeA-3gxaA: 21.96 4koeB-3gxaA: 21.96 4koeD-3gxaA: 21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3hkz	DNA-DIRECTED RNA POLYMERASE SUBUNIT B (Sulfolobus solfataricus)	PF00562 (RNA_pol_Rpb2_6) PF04560 (RNA_pol_Rpb2_7) PF04561 (RNA_pol_Rpb2_2) PF04563 (RNA_pol_Rpb2_1) PF04565 (RNA_pol_Rpb2_3) PF04566 (RNA_pol_Rpb2_4) PF04567 (RNA_pol_Rpb2_5)	4	ARG B 525 GLY B 302 ASP B 307 GLY B 195	None	0.95A	4koeA-3hkzB: undetectable 4koeB-3hkzB: undetectable 4koeD-3hkzB: undetectable	4koeA-3hkzB: 19.36 4koeB-3hkzB: 19.36 4koeD-3hkzB: 12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ir1	OUTER MEMBRANE LIPOPROTEIN GNA1946 (Neisseria meningitidis)	PF03180 (Lipoprotein_9)	4	SER A 203 GLY A 214 GLY A 127 GLU A 231	None	0.93A	4koeA-3ir1A: undetectable 4koeB-3ir1A: undetectable 4koeD-3ir1A: undetectable	4koeA-3ir1A: 19.64 4koeB-3ir1A: 19.64 4koeD-3ir1A: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3it4	ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ BETA CHAIN (Mycobacterium tuberculosis)	PF01960 (ArgJ)	4	ARG B 285 ASP B 278 GLY B 281 GLU B 398	None	0.83A	4koeA-3it4B: undetectable 4koeB-3it4B: undetectable 4koeD-3it4B: undetectable	4koeA-3it4B: 19.26 4koeB-3it4B: 19.26 4koeD-3it4B: 20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3jtj	3-DEOXY-MANNO-OCTULO SONATE CYTIDYLYLTRANSFERASE (Yersinia pestis)	PF02348 (CTP_transf_3)	4	SER A   2 GLY A 190 ASP A  90 GLU A  84	None	0.91A	4koeA-3jtjA: undetectable 4koeB-3jtjA: undetectable 4koeD-3jtjA: undetectable	4koeA-3jtjA: 19.23 4koeB-3jtjA: 19.23 4koeD-3jtjA: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lnp	AMIDOHYDROLASE FAMILY PROTEIN OLEI01672_1_465 (Oleispira antarctica)	PF01979 (Amidohydro_1)	4	SER A 141 GLY A  89 ASP A 148 GLY A 332	None	0.91A	4koeA-3lnpA: undetectable 4koeB-3lnpA: undetectable 4koeD-3lnpA: undetectable	4koeA-3lnpA: 23.94 4koeB-3lnpA: 23.94 4koeD-3lnpA: 20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3nuz	PUTATIVE ACETYL XYLAN ESTERASE (Bacteroides fragilis)	PF12715 (Abhydrolase_7)	4	SER A 402 GLY A 148 GLY A 152 GLU A 151	None	0.75A	4koeA-3nuzA: undetectable 4koeB-3nuzA: undetectable 4koeD-3nuzA: 3.0	4koeA-3nuzA: 22.70 4koeB-3nuzA: 22.70 4koeD-3nuzA: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3o07	PYRIDOXINE BIOSYNTHESIS PROTEIN SNZ1 (Saccharomyces cerevisiae)	PF01680 (SOR_SNZ)	4	ARG A 146 SER A 103 GLY A 214 GLY A 152	None	0.89A	4koeA-3o07A: undetectable 4koeB-3o07A: undetectable 4koeD-3o07A: undetectable	4koeA-3o07A: 21.91 4koeB-3o07A: 21.91 4koeD-3o07A: 23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3os6	ISOCHORISMATE SYNTHASE DHBC (Bacillus anthracis)	PF00425 (Chorismate_bind)	4	GLY A 214 ASP A 238 GLY A 364 GLU A 374	SO4  A 404 (-3.8A) None SO4  A 404 (-3.8A) None	0.88A	4koeA-3os6A: undetectable 4koeB-3os6A: undetectable 4koeD-3os6A: undetectable	4koeA-3os6A: 23.12 4koeB-3os6A: 23.12 4koeD-3os6A: 21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3p2m	POSSIBLE HYDROLASE (Mycobacterium tuberculosis)	PF12697 (Abhydrolase_6)	4	SER A 310 GLY A 117 ASP A 112 GLU A  44	None	0.86A	4koeA-3p2mA: undetectable 4koeB-3p2mA: undetectable 4koeD-3p2mA: 3.9	4koeA-3p2mA: 20.24 4koeB-3p2mA: 20.24 4koeD-3p2mA: 25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3pa7	70 KDA PEPTIDYLPROLYL ISOMERASE, PUTATIVE (Plasmodium vivax)	PF00254 (FKBP_C)	4	SER A  49 GLY A  99 GLY A 104 GLU A 103	None	0.78A	4koeA-3pa7A: undetectable 4koeB-3pa7A: undetectable 4koeD-3pa7A: undetectable	4koeA-3pa7A: 12.78 4koeB-3pa7A: 12.78 4koeD-3pa7A: 18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3qgh	RNA-DIRECTED RNA POLYMERASE (Hepacivirus C)	PF00998 (RdRP_3)	4	GLY A 558 ASP A 559 GLY A 449 GLU A 446	None	0.87A	4koeA-3qghA: 2.9 4koeB-3qghA: 2.8 4koeD-3qghA: undetectable	4koeA-3qghA: 21.65 4koeB-3qghA: 21.65 4koeD-3qghA: 19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3qgh	RNA-DIRECTED RNA POLYMERASE (Hepacivirus C)	PF00998 (RdRP_3)	4	SER A 121 GLY A 104 ASP A 107 GLY A 102	None	0.91A	4koeA-3qghA: 2.9 4koeB-3qghA: 2.8 4koeD-3qghA: undetectable	4koeA-3qghA: 21.65 4koeB-3qghA: 21.65 4koeD-3qghA: 19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	no annotation	4	SER M 489 GLY M 402 GLY M 406 GLU M 407	None	0.90A	4koeA-3rkoM: undetectable 4koeB-3rkoM: undetectable 4koeD-3rkoM: undetectable	4koeA-3rkoM: 21.18 4koeB-3rkoM: 21.18 4koeD-3rkoM: 18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3suc	PRENECK APPENDAGE PROTEIN (Bacillus virus phi29)	PF11962 (Peptidase_G2) PF12708 (Pectate_lyase_3)	4	SER A 456 GLY A 531 ASP A 506 GLY A 503	None	0.84A	4koeA-3sucA: undetectable 4koeB-3sucA: undetectable 4koeD-3sucA: undetectable	4koeA-3sucA: 20.40 4koeB-3sucA: 20.40 4koeD-3sucA: 15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3sze	SERINE PROTEASE ESPP (Escherichia coli)	PF02395 (Peptidase_S6)	4	SER A 143 GLY A 453 ASP A 452 GLY A 477	None	0.81A	4koeA-3szeA: undetectable 4koeB-3szeA: undetectable 4koeD-3szeA: undetectable	4koeA-3szeA: 18.75 4koeB-3szeA: 18.75 4koeD-3szeA: 13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3up9	PUTATIVE UNCHARACTERIZED PROTEIN (Actinomyces odontolyticus)	PF03180 (Lipoprotein_9)	4	SER A 196 GLY A 207 GLY A 123 GLU A 225	None	0.81A	4koeA-3up9A: undetectable 4koeB-3up9A: undetectable 4koeD-3up9A: undetectable	4koeA-3up9A: 21.38 4koeB-3up9A: 21.38 4koeD-3up9A: 22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3zeu	PROBABLE TRNA THREONYLCARBAMOYLADE NOSINE BIOSYNTHESIS PROTEIN GCP (Salmonella enterica)	PF00814 (Peptidase_M22)	4	SER B   9 GLY B 163 ASP B 167 GLY B 268	AGS  B1342 ( 4.9A) ADP  B1343 (-3.3A) ADP  B1343 (-2.9A) AGS  B1342 (-3.1A)	0.86A	4koeA-3zeuB: undetectable 4koeB-3zeuB: undetectable 4koeD-3zeuB: undetectable	4koeA-3zeuB: 23.53 4koeB-3zeuB: 23.53 4koeD-3zeuB: 22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4a2l	TWO-COMPONENT SYSTEM SENSOR HISTIDINE KINASE/RESPONSE (Bacteroides thetaiotaomicron)	PF07494 (Reg_prop) PF07495 (Y_Y_Y)	4	SER A 360 GLY A 404 GLY A 428 GLU A 452	None	0.85A	4koeA-4a2lA: undetectable 4koeB-4a2lA: undetectable 4koeD-4a2lA: undetectable	4koeA-4a2lA: 21.81 4koeB-4a2lA: 21.81 4koeD-4a2lA: 16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4acz	ENDO-ALPHA-MANNOSIDA SE (Bacteroides thetaiotaomicron)	PF16317 (Glyco_hydro_99)	4	SER B 121 GLY B 244 ASP B 243 GLY B 226	None	0.89A	4koeA-4aczB: undetectable 4koeB-4aczB: undetectable 4koeD-4aczB: undetectable	4koeA-4aczB: 21.69 4koeB-4aczB: 21.69 4koeD-4aczB: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4cta	CINA-LIKE PROTEIN (Thermus thermophilus)	PF00994 (MoCF_biosynth) PF02464 (CinA)	4	GLY A  69 ASP A  76 GLY A  10 GLU A  12	ATP  A 400 (-3.6A) ATP  A 400 (-3.7A) None None	0.94A	4koeA-4ctaA: undetectable 4koeB-4ctaA: 3.3 4koeD-4ctaA: 2.3	4koeA-4ctaA: 23.09 4koeB-4ctaA: 23.09 4koeD-4ctaA: 19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4f0l	AMIDOHYDROLASE (Brucella abortus)	PF01979 (Amidohydro_1)	4	SER A 342 GLY A 323 ASP A 325 GLY A 294	None None FE  A 501 (-2.8A) None	0.91A	4koeA-4f0lA: undetectable 4koeB-4f0lA: undetectable 4koeD-4f0lA: undetectable	4koeA-4f0lA: 22.64 4koeB-4f0lA: 22.64 4koeD-4f0lA: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4grx	AMINOTRANSFERASE (Paracoccus denitrificans)	PF00202 (Aminotran_3)	4	ARG A 264 SER A  54 GLY A 266 GLU A 347	None	0.91A	4koeA-4grxA: 3.2 4koeB-4grxA: 3.1 4koeD-4grxA: undetectable	4koeA-4grxA: 23.26 4koeB-4grxA: 23.26 4koeD-4grxA: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4j3b	M1 FAMILY AMINOPEPTIDASE (Plasmodium falciparum)	PF01433 (Peptidase_M1) PF11940 (DUF3458) PF17432 (DUF3458_C)	4	SER A 316 GLY A 357 ASP A 376 GLY A 466	None	0.87A	4koeA-4j3bA: 2.1 4koeB-4j3bA: undetectable 4koeD-4j3bA: undetectable	4koeA-4j3bA: 19.82 4koeB-4j3bA: 19.82 4koeD-4j3bA: 14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4j9t	DESIGNED UNNATURAL AMINO ACID DEPENDENT METALLOPROTEIN (Micromonospora viridifaciens)	PF13088 (BNR_2)	4	GLY A 293 ASP A 291 GLY A 251 GLU A 252	None GOL  A 501 (-4.7A) None None	0.95A	4koeA-4j9tA: undetectable 4koeB-4j9tA: undetectable 4koeD-4j9tA: undetectable	4koeA-4j9tA: 21.38 4koeB-4j9tA: 21.38 4koeD-4j9tA: 17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4jdy	PYRIDOXAL BIOSYNTHESIS LYASE PDXS (Mycobacterium tuberculosis)	PF01680 (SOR_SNZ)	4	ARG A 152 SER A 109 GLY A 219 GLY A 158	None	0.93A	4koeA-4jdyA: undetectable 4koeB-4jdyA: undetectable 4koeD-4jdyA: undetectable	4koeA-4jdyA: 20.00 4koeB-4jdyA: 20.00 4koeD-4jdyA: 23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4kq7	HYPOTHETICAL PROTEIN (Bacteroides uniformis)	PF11175 (DUF2961)	4	GLY A 294 ASP A 277 GLY A 274 GLU A 230	None	0.92A	4koeA-4kq7A: undetectable 4koeB-4kq7A: undetectable 4koeD-4kq7A: undetectable	4koeA-4kq7A: 21.44 4koeB-4kq7A: 21.44 4koeD-4kq7A: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4nd4	LACTATE DEHYDROGENASE, ADJACENT GENE ENCODES PREDICTED MALATE DEHYDROGENASE (Cryptosporidium parvum)	PF00056 (Ldh_1_N) PF02866 (Ldh_1_C)	4	SER A 205 GLY A 165 ASP A 168 GLY A 288	None	0.79A	4koeA-4nd4A: undetectable 4koeB-4nd4A: undetectable 4koeD-4nd4A: 2.4	4koeA-4nd4A: 21.85 4koeB-4nd4A: 21.85 4koeD-4nd4A: 20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4nh0	CELL DIVISIONFTSK/SPOIIIE (Thermomonospora curvata)	PF01580 (FtsK_SpoIIIE)	4	SER A1150 GLY A1116 ASP A1117 GLY A1121	None None None ATP  A1404 (-3.2A)	0.93A	4koeA-4nh0A: undetectable 4koeB-4nh0A: undetectable 4koeD-4nh0A: 3.2	4koeA-4nh0A: 18.05 4koeB-4nh0A: 18.05 4koeD-4nh0A: 13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4op4	SUCCINYL-DIAMINOPIME LATE DESUCCINYLASE (Vibrio cholerae)	PF01546 (Peptidase_M20)	4	SER A 105 GLY A 218 ASP A 217 GLY A 214	None BU1  A 307 ( 3.7A) None BU1  A 307 (-4.1A)	0.85A	4koeA-4op4A: undetectable 4koeB-4op4A: undetectable 4koeD-4op4A: 3.3	4koeA-4op4A: 20.48 4koeB-4op4A: 20.48 4koeD-4op4A: 21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4plb	CHIMERA PROTEIN OF DNA GYRASE SUBUNITS B AND A (Staphylococcus aureus)	PF00521 (DNA_topoisoIV) PF00986 (DNA_gyraseB_C) PF01751 (Toprim)	4	SER B1084 GLY B 436 GLY B 459 GLU B 477	None	0.91A	4koeA-4plbB: 53.6 4koeB-4plbB: 53.4 4koeD-4plbB: 28.2	4koeA-4plbB: 32.71 4koeB-4plbB: 32.71 4koeD-4plbB: 19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4r1d	UNCHARACTERIZED PROTEIN (Pseudomonas aeruginosa)	no annotation	4	ARG A 531 GLY A 432 ASP A 497 GLY A 495	None	0.93A	4koeA-4r1dA: undetectable 4koeB-4r1dA: undetectable 4koeD-4r1dA: 3.7	4koeA-4r1dA: 20.96 4koeB-4r1dA: 20.96 4koeD-4r1dA: 17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wxz	PYRIDOXAL BIOSYNTHESIS LYASE PDXS (Geobacillus kaustophilus)	PF01680 (SOR_SNZ)	4	ARG A 147 SER A 104 GLY A 214 GLY A 153	None L5P  A  81 ( 3.8A) L5P  A  81 ( 3.7A) L5P  A  81 ( 3.8A)	0.86A	4koeA-4wxzA: undetectable 4koeB-4wxzA: undetectable 4koeD-4wxzA: undetectable	4koeA-4wxzA: 21.33 4koeB-4wxzA: 21.33 4koeD-4wxzA: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4x8f	RIBOKINASE (Vibrio cholerae)	PF00294 (PfkB)	4	SER A 282 GLY A  38 ASP A  13 GLU A 140	None	0.92A	4koeA-4x8fA: undetectable 4koeB-4x8fA: undetectable 4koeD-4x8fA: 2.2	4koeA-4x8fA: 20.95 4koeB-4x8fA: 20.95 4koeD-4x8fA: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4y7d	ALPHA/BETA HYDROLASE FOLD PROTEIN (Nakamurella multipartita)	PF00561 (Abhydrolase_1)	4	SER A 110 GLY A  42 ASP A  64 GLY A  46	None	0.85A	4koeA-4y7dA: undetectable 4koeB-4y7dA: undetectable 4koeD-4y7dA: 3.2	4koeA-4y7dA: 20.56 4koeB-4y7dA: 20.56 4koeD-4y7dA: 19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4z2e	DNA GYRASE SUBUNIT B (Streptococcus pneumoniae)	PF00986 (DNA_gyraseB_C) PF01751 (Toprim)	4	GLY C 434 ASP C 435 GLY C 457 GLU C 475	None	0.72A	4koeA-4z2eC: undetectable 4koeB-4z2eC: undetectable 4koeD-4z2eC: 27.2	4koeA-4z2eC: 19.15 4koeB-4z2eC: 19.15 4koeD-4z2eC: 57.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4z3o	DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE (Streptococcus pneumoniae)	PF00521 (DNA_topoisoIV) PF00986 (DNA_gyraseB_C) PF01751 (Toprim)	4	GLY A 434 ASP A 435 GLY A 457 GLU A 475	None	0.24A	4koeA-4z3oA: 57.9 4koeB-4z3oA: 57.4 4koeD-4z3oA: 32.0	4koeA-4z3oA: 66.85 4koeB-4z3oA: 66.85 4koeD-4z3oA: 91.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4z3o	DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE (Streptococcus pneumoniae)	PF00521 (DNA_topoisoIV) PF00986 (DNA_gyraseB_C) PF01751 (Toprim)	4	SER A1080 GLY A 434 GLY A 457 GLU A 475	None	0.65A	4koeA-4z3oA: 57.9 4koeB-4z3oA: 57.4 4koeD-4z3oA: 32.0	4koeA-4z3oA: 66.85 4koeB-4z3oA: 66.85 4koeD-4z3oA: 91.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5by7	3-OXOACYL-ACP SYNTHASE III (Verrucosispora maris)	PF08541 (ACP_syn_III_C) PF08545 (ACP_syn_III)	4	SER A 315 GLY A 131 ASP A 132 GLY A  71	None	0.89A	4koeA-5by7A: undetectable 4koeB-5by7A: undetectable 4koeD-5by7A: undetectable	4koeA-5by7A: 23.97 4koeB-5by7A: 23.97 4koeD-5by7A: 24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5cdo	DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B (Staphylococcus aureus)	PF00986 (DNA_gyraseB_C) PF01751 (Toprim)	4	GLY B 436 ASP B 437 GLY B 459 GLU B 477	None	0.64A	4koeA-5cdoB: undetectable 4koeB-5cdoB: undetectable 4koeD-5cdoB: 29.5	4koeA-5cdoB: 17.99 4koeB-5cdoB: 17.99 4koeD-5cdoB: 53.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5f1q	PERIPLASMIC DIPEPTIDE TRANSPORT PROTEIN (Yersinia pestis)	PF00496 (SBP_bac_5)	4	SER A 184 GLY A 525 GLY A  50 GLU A  36	None GLN  A 608 (-3.8A) GLN  A 608 ( 3.2A) None	0.79A	4koeA-5f1qA: 3.2 4koeB-5f1qA: 3.1 4koeD-5f1qA: undetectable	4koeA-5f1qA: 23.29 4koeB-5f1qA: 23.29 4koeD-5f1qA: 18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5fok	IRON TRANSPORT OUTER MEMBRANE RECEPTOR (Pseudomonas aeruginosa)	PF00593 (TonB_dep_Rec) PF07715 (Plug)	4	SER A  38 GLY A 143 ASP A 103 GLY A 132	None	0.77A	4koeA-5fokA: undetectable 4koeB-5fokA: undetectable 4koeD-5fokA: undetectable	4koeA-5fokA: 21.39 4koeB-5fokA: 21.39 4koeD-5fokA: 16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5g4g	VCP-LIKE ATPASE (Thermoplasma acidophilum)	PF00004 (AAA) PF02359 (CDC48_N) PF02933 (CDC48_2)	4	SER A 453 GLY A 362 ASP A 359 GLU A 388	None	0.88A	4koeA-5g4gA: undetectable 4koeB-5g4gA: undetectable 4koeD-5g4gA: undetectable	4koeA-5g4gA: 21.39 4koeB-5g4gA: 21.39 4koeD-5g4gA: 17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5gwj	DNA TOPOISOMERASE 2-BETA (Homo sapiens)	PF00521 (DNA_topoisoIV) PF01751 (Toprim) PF16898 (TOPRIM_C)	4	GLY A 478 ASP A 479 GLY A 504 GLU A 522	N2W  A1302 ( 3.0A) N2W  A1302 ( 3.4A) N2W  A1302 ( 4.4A) None	0.78A	4koeA-5gwjA: 8.6 4koeB-5gwjA: 31.1 4koeD-5gwjA: 19.9	4koeA-5gwjA: 21.86 4koeB-5gwjA: 21.86 4koeD-5gwjA: 16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hsg	PUTATIVE ABC TRANSPORTER, NUCLEOTIDE BINDING/ATPASE PROTEIN (Klebsiella pneumoniae)	PF13407 (Peripla_BP_4)	4	SER A 169 GLY A 139 ASP A 135 GLY A 178	None	0.95A	4koeA-5hsgA: undetectable 4koeB-5hsgA: undetectable 4koeD-5hsgA: 3.6	4koeA-5hsgA: 22.54 4koeB-5hsgA: 22.54 4koeD-5hsgA: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5jzd	ISOCHORISMATE SYNTHASE ENTC (Escherichia coli)	PF00425 (Chorismate_bind)	4	GLY A 214 ASP A 238 GLY A 363 GLU A 373	ISC  A 401 (-3.2A) None ISC  A 401 (-3.3A) MG  A 402 ( 4.5A)	0.91A	4koeA-5jzdA: undetectable 4koeB-5jzdA: 1.3 4koeD-5jzdA: undetectable	4koeA-5jzdA: 22.68 4koeB-5jzdA: 22.68 4koeD-5jzdA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5k2z	PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT PDX1.3 (Arabidopsis thaliana)	PF01680 (SOR_SNZ)	4	ARG A 163 SER A 120 GLY A 230 GLY A 169	6R3  A 404 (-3.8A) 6R3  A 404 (-3.1A) SO4  A 403 (-3.4A) SO4  A 403 (-3.6A)	0.84A	4koeA-5k2zA: undetectable 4koeB-5k2zA: undetectable 4koeD-5k2zA: undetectable	4koeA-5k2zA: 22.07 4koeB-5k2zA: 22.07 4koeD-5k2zA: 22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5k3h	ACYL-COENZYME A OXIDASE (Caenorhabditis elegans)	PF01756 (ACOX) PF02770 (Acyl-CoA_dh_M) PF14749 (Acyl-CoA_ox_N)	4	SER A  75 GLY A 194 ASP A 238 GLY A 191	None	0.83A	4koeA-5k3hA: undetectable 4koeB-5k3hA: undetectable 4koeD-5k3hA: undetectable	4koeA-5k3hA: 24.60 4koeB-5k3hA: 24.60 4koeD-5k3hA: 17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ko5	PURINE NUCLEOSIDE PHOSPHORYLASE (Schistosoma mansoni)	PF01048 (PNP_UDP_1)	5	ARG A  86 SER A 222 GLY A  38 GLY A  36 GLU A 267	EDO  A 302 (-4.3A) EDO  A 302 (-3.0A) None None None	1.35A	4koeA-5ko5A: undetectable 4koeB-5ko5A: undetectable 4koeD-5ko5A: 2.9	4koeA-5ko5A: 21.96 4koeB-5ko5A: 21.96 4koeD-5ko5A: 24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5l3r	CELL DIVISION PROTEIN FTSY HOMOLOG, CHLOROPLASTIC SIGNAL RECOGNITION PARTICLE 54 KDA PROTEIN, CHLOROPLASTIC (Arabidopsis thaliana)	PF00448 (SRP54) PF02881 (SRP54_N)	4	SER B 331 ASP B 292 GLY A 301 GLU A 303	None	0.96A	4koeA-5l3rB: undetectable 4koeB-5l3rB: undetectable 4koeD-5l3rB: 4.0	4koeA-5l3rB: 19.76 4koeB-5l3rB: 19.76 4koeD-5l3rB: 25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5lnt	PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT PDX1.1 (Arabidopsis thaliana)	PF01680 (SOR_SNZ)	4	ARG A 164 SER A 121 GLY A 231 GLY A 170	KPR  A 401 (-4.0A) KPR  A 401 (-3.2A) KPR  A 401 (-3.6A) KPR  A 401 (-3.9A)	0.85A	4koeA-5lntA: undetectable 4koeB-5lntA: undetectable 4koeD-5lntA: undetectable	4koeA-5lntA: 22.76 4koeB-5lntA: 22.76 4koeD-5lntA: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5m49	AMINOTRANSFERASE CLASS-III (Rhizobium freirei)	PF00202 (Aminotran_3)	4	SER A 247 GLY A 219 ASP A 218 GLY A 257	None	0.96A	4koeA-5m49A: 1.1 4koeB-5m49A: undetectable 4koeD-5m49A: undetectable	4koeA-5m49A: 22.93 4koeB-5m49A: 22.93 4koeD-5m49A: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5m60	BETA-1,3-GLUCANASE (Chaetomium thermophilum)	PF12708 (Pectate_lyase_3)	4	ARG A 246 ASP A 389 GLY A 531 GLU A 529	None	0.94A	4koeA-5m60A: undetectable 4koeB-5m60A: undetectable 4koeD-5m60A: undetectable	4koeA-5m60A: 20.25 4koeB-5m60A: 20.25 4koeD-5m60A: 15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5neu	INTEGRIN ALPHA-V (Homo sapiens)	PF01839 (FG-GAP) PF08441 (Integrin_alpha2)	5	ARG A 168 SER A 185 GLY A 235 ASP A 234 GLY A 229	None	1.22A	4koeA-5neuA: undetectable 4koeB-5neuA: undetectable 4koeD-5neuA: undetectable	4koeA-5neuA: 23.88 4koeB-5neuA: 23.88 4koeD-5neuA: 18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5oet	GLUTATHIONE SYNTHETASE-LIKE EFFECTOR 30 (GPA-GSS30-APO) (Globodera pallida)	no annotation	4	SER B 333 ASP B 303 GLY B 287 GLU B 286	None	0.88A	4koeA-5oetB: undetectable 4koeB-5oetB: undetectable 4koeD-5oetB: undetectable	4koeA-5oetB: 10.88 4koeB-5oetB: 10.88 4koeD-5oetB: 12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5th6	MATRIX METALLOPROTEINASE-9, MATRIX METALLOPROTEINASE-9 (Homo sapiens)	PF00413 (Peptidase_M10) PF01471 (PG_binding_1)	4	ARG A 106 GLY A 112 ASP A 113 GLY A 195	None	0.90A	4koeA-5th6A: undetectable 4koeB-5th6A: undetectable 4koeD-5th6A: undetectable	4koeA-5th6A: 18.15 4koeB-5th6A: 18.15 4koeD-5th6A: 20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5uz9	CRISPR-ASSOCIATED PROTEIN CSY2 (Pseudomonas aeruginosa)	PF09614 (Cas_Csy2)	4	GLY B 117 ASP B 119 GLY B 115 GLU B   7	None	0.84A	4koeA-5uz9B: undetectable 4koeB-5uz9B: undetectable 4koeD-5uz9B: undetectable	4koeA-5uz9B: 22.29 4koeB-5uz9B: 22.29 4koeD-5uz9B: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5v0t	ALPHA,ALPHA-TREHALOS E-PHOSPHATE SYNTHASE (UDP-FORMING) (Paraburkholderia xenovorans)	PF00982 (Glyco_transf_20)	4	ARG A 458 GLY A  35 ASP A  38 GLY A 240	ACT  A 506 (-4.3A) None None None	0.87A	4koeA-5v0tA: undetectable 4koeB-5v0tA: undetectable 4koeD-5v0tA: 3.2	4koeA-5v0tA: 21.74 4koeB-5v0tA: 21.74 4koeD-5v0tA: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5v9x	ATP-DEPENDENT DNA HELICASE (Mycolicibacterium smegmatis)	no annotation	4	GLY A 613 ASP A 661 GLY A 617 GLU A 618	None	0.95A	4koeA-5v9xA: 5.4 4koeB-5v9xA: 5.6 4koeD-5v9xA: undetectable	4koeA-5v9xA: 9.49 4koeB-5v9xA: 9.49 4koeD-5v9xA: 19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5wgc	DAUNORUBICIN-DOXORUB ICIN POLYKETIDE SYNTHASE (Streptomyces peucetius)	no annotation	4	SER A 326 GLY A 146 ASP A 147 GLU A 113	42Y  A 118 ( 3.7A) None None None	0.76A	4koeA-5wgcA: undetectable 4koeB-5wgcA: undetectable 4koeD-5wgcA: undetectable	4koeA-5wgcA: 10.08 4koeB-5wgcA: 10.08 4koeD-5wgcA: 13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6bvg	PROTEIN-N(PI)-PHOSPH OHISTIDINE-SUGAR PHOSPHOTRANSFERASE (ENZYME II OF THE PHOSPHOTRANSFERASE SYSTEM) (PTS SYSTEM GLUCOSE-SPECIFIC IIBC COMPONENT) (Bacillus cereus)	no annotation	5	ARG A 305 SER A 215 GLY A 309 GLY A 228 GLU A 231	None None None None MAL  A 501 (-3.6A)	1.21A	4koeA-6bvgA: undetectable 4koeB-6bvgA: undetectable 4koeD-6bvgA: undetectable	4koeA-6bvgA: 8.88 4koeB-6bvgA: 8.88 4koeD-6bvgA: 18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6epd	PROTEASOME SUBUNIT BETA TYPE-4 (Rattus norvegicus)	no annotation	4	SER 7 142 GLY 7  99 ASP 7 100 GLY 7 157	None	0.68A	4koeA-6epd7: undetectable 4koeB-6epd7: undetectable 4koeD-6epd7: undetectable	4koeA-6epd7: 9.92 4koeB-6epd7: 9.92 4koeD-6epd7: 11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6fn1	HUMAN-MOUSE CHIMERIC ABCB1 (ABCBHM) (Homo sapiens)	no annotation	4	ARG A1232 SER A1234 GLY A1178 ASP A1206	None	0.91A	4koeA-6fn1A: undetectable 4koeB-6fn1A: undetectable 4koeD-6fn1A: undetectable	4koeA-6fn1A: 10.55 4koeB-6fn1A: 10.55 4koeD-6fn1A: 16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6gne	- (-)	no annotation	4	SER A 501 GLY A  42 ASP A  45 GLY A 415	None ADP  A 601 ( 3.2A) ADP  A 601 (-3.4A) ADP  A 601 ( 3.5A)	0.89A	4koeA-6gneA: undetectable 4koeB-6gneA: undetectable 4koeD-6gneA: 2.5	4koeA-6gneA: undetectable 4koeB-6gneA: undetectable 4koeD-6gneA: undetectable