SIMILAR PATTERNS OF AMINO ACIDS FOR 4KN2_A_LYAA304_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p30 1281 FAB HEAVY CHAIN
1281 FAB LIGHT CHAIN
HIV-1 GP41

(Homo sapiens;
Human
immunodeficiency
virus 1) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		4 TYR L  49
GLN A 650
ARG H  94
TRP H 103
 None
 1.13A 4kn2A-3p30L:
0.0		 4kn2A-3p30L:
18.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kmz FOLATE RECEPTOR BETA

(Homo sapiens) 		PF03024
(Folate_rec) 		4 TYR A  76
GLN A 116
ARG A 152
TRP A 154
 FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-4.0A)
None
 0.16A 4kn2A-4kmzA:
37.6		 4kn2A-4kmzA:
100.00