SIMILAR PATTERNS OF AMINO ACIDS FOR 4KN0_A_MTXA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ral	3-ALPHA-HYDROXYSTERO ID DEHYDROGENASE (Rattus norvegicus)	PF00248 (Aldo_ket_red)	5	ASP A 50 TYR A 216 GLN A 199 GLY A 264 SER A 166	None	1.33A	4kn0A-1ralA: 0.0	4kn0A-1ralA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2vqd	BIOTIN CARBOXYLASE (Pseudomonas aeruginosa)	PF00289 (Biotin_carb_N) PF02785 (Biotin_carb_C) PF02786 (CPSase_L_D2)	5	PHE A 284 GLN A 294 ARG A 228 GLY A 226 SER A 231	None	1.20A	4kn0A-2vqdA: 0.0	4kn0A-2vqdA: 16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ine	PROTEIN PMT-2 (Caenorhabditis elegans)	PF08241 (Methyltransf_11)	5	TYR A 187 TYR A 195 GLN A 346 ARG A 347 SER A 407	SAH A 501 ( 4.1A) OPE A 502 (-3.9A) None OPE A 502 (-3.9A) None	1.36A	4kn0A-4ineA: 0.0	4kn0A-4ineA: 17.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4kmz	FOLATE RECEPTOR BETA (Homo sapiens)	PF03024 (Folate_rec)	10	TYR A 76 PHE A 78 ASP A 97 TYR A 101 GLN A 116 ARG A 152 GLY A 153 TRP A 156 TRP A 187 SER A 190	FOL A 301 (-3.8A) FOL A 301 ( 4.9A) FOL A 301 (-2.8A) FOL A 301 (-3.8A) FOL A 301 ( 4.8A) FOL A 301 (-4.0A) FOL A 301 (-4.0A) FOL A 301 (-3.7A) FOL A 301 (-3.5A) FOL A 301 (-2.6A)	0.82A	4kn0A-4kmzA: 36.9	4kn0A-4kmzA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4kmz	FOLATE RECEPTOR BETA (Homo sapiens)	PF03024 (Folate_rec)	11	TYR A 76 PHE A 78 ASP A 97 TYR A 101 GLN A 116 TRP A 118 ARG A 119 ARG A 152 GLY A 153 TRP A 156 TRP A 187	FOL A 301 (-3.8A) FOL A 301 ( 4.9A) FOL A 301 (-2.8A) FOL A 301 (-3.8A) FOL A 301 ( 4.8A) FOL A 301 (-4.0A) FOL A 301 (-3.0A) FOL A 301 (-4.0A) FOL A 301 (-4.0A) FOL A 301 (-3.7A) FOL A 301 (-3.5A)	0.69A	4kn0A-4kmzA: 36.9	4kn0A-4kmzA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4lrh	FOLATE RECEPTOR ALPHA (Homo sapiens)	PF03024 (Folate_rec)	6	PHE A 62 ASP A 81 GLY A 137 TRP A 140 TRP A 171 SER A 174	None FOL A 301 (-2.7A) FOL A 301 (-4.3A) FOL A 301 (-3.6A) FOL A 301 (-3.7A) FOL A 301 (-2.8A)	0.73A	4kn0A-4lrhA: 34.6	4kn0A-4lrhA: 77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4lrh	FOLATE RECEPTOR ALPHA (Homo sapiens)	PF03024 (Folate_rec)	8	TYR A 60 PHE A 62 ASP A 81 TYR A 85 GLN A 100 TRP A 102 ARG A 103 TRP A 171	FOL A 301 (-3.9A) None FOL A 301 (-2.7A) FOL A 301 (-4.1A) FOL A 301 (-4.3A) FOL A 301 (-4.2A) FOL A 301 (-3.2A) FOL A 301 (-3.7A)	0.68A	4kn0A-4lrhA: 34.6	4kn0A-4lrhA: 77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4lrh	FOLATE RECEPTOR ALPHA (Homo sapiens)	PF03024 (Folate_rec)	9	TYR A 60 PHE A 62 ASP A 81 TYR A 85 TRP A 102 ARG A 103 GLY A 137 TRP A 140 TRP A 171	FOL A 301 (-3.9A) None FOL A 301 (-2.7A) FOL A 301 (-4.1A) FOL A 301 (-4.2A) FOL A 301 (-3.2A) FOL A 301 (-4.3A) FOL A 301 (-3.6A) FOL A 301 (-3.7A)	0.64A	4kn0A-4lrhA: 34.6	4kn0A-4lrhA: 77.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ve3	BPPRF (Paraburkholderia phytofirmans)	no annotation	5	PHE B 332 ASP B 307 ARG B 290 ARG B 300 GLY B 299	None	1.31A	4kn0A-5ve3B: 0.0	4kn0A-5ve3B: 19.14

[["4KN0_A_MTXA301_1","1ral","Rattus norvegicus","3-ALPHA-HYDROXYSTEROID DEHYDROGENASE","PF00248(Aldo_ket_red)",5,"ASP A  50;TYR A 216;GLN A 199;GLY A 264;SER A 166","None","1.33A","4kn0A-1ralA:0.0","4kn0A-1ralA:21.34"],["4KN0_A_MTXA301_1","2vqd","Pseudomonas aeruginosa","BIOTIN CARBOXYLASE","PF00289(Biotin_carb_N);PF02785(Biotin_carb_C);PF02786(CPSase_L_D2)",5,"PHE A 284;GLN A 294;ARG A 228;GLY A 226;SER A 231","None","1.20A","4kn0A-2vqdA:0.0","4kn0A-2vqdA:16.45"],["4KN0_A_MTXA301_1","4ine","Caenorhabditis elegans","PROTEIN PMT-2","PF08241(Methyltransf_11)",5,"TYR A 187;TYR A 195;GLN A 346;ARG A 347;SER A 407","SAH A 501 ( 4.1A);OPE A 502 (-3.9A);None;OPE A 502 (-3.9A);None","1.36A","4kn0A-4ineA:0.0","4kn0A-4ineA:17.82"],["4KN0_A_MTXA301_1","4kmz","Homo sapiens","FOLATE RECEPTOR BETA","PF03024(Folate_rec)",10,"TYR A  76;PHE A  78;ASP A  97;TYR A 101;GLN A 116;ARG A 152;GLY A 153;TRP A 156;TRP A 187;SER A 190","FOL A 301 (-3.8A);FOL A 301 ( 4.9A);FOL A 301 (-2.8A);FOL A 301 (-3.8A);FOL A 301 ( 4.8A);FOL A 301 (-4.0A);FOL A 301 (-4.0A);FOL A 301 (-3.7A);FOL A 301 (-3.5A);FOL A 301 (-2.6A)","0.82A","4kn0A-4kmzA:36.9","4kn0A-4kmzA:100.00"],["4KN0_A_MTXA301_1","4kmz","Homo sapiens","FOLATE RECEPTOR BETA","PF03024(Folate_rec)",11,"TYR A  76;PHE A  78;ASP A  97;TYR A 101;GLN A 116;TRP A 118;ARG A 119;ARG A 152;GLY A 153;TRP A 156;TRP A 187","FOL A 301 (-3.8A);FOL A 301 ( 4.9A);FOL A 301 (-2.8A);FOL A 301 (-3.8A);FOL A 301 ( 4.8A);FOL A 301 (-4.0A);FOL A 301 (-3.0A);FOL A 301 (-4.0A);FOL A 301 (-4.0A);FOL A 301 (-3.7A);FOL A 301 (-3.5A)","0.69A","4kn0A-4kmzA:36.9","4kn0A-4kmzA:100.00"],["4KN0_A_MTXA301_1","4lrh","Homo sapiens","FOLATE RECEPTOR ALPHA","PF03024(Folate_rec)",6,"PHE A  62;ASP A  81;GLY A 137;TRP A 140;TRP A 171;SER A 174","None;FOL A 301 (-2.7A);FOL A 301 (-4.3A);FOL A 301 (-3.6A);FOL A 301 (-3.7A);FOL A 301 (-2.8A)","0.73A","4kn0A-4lrhA:34.6","4kn0A-4lrhA:77.36"],["4KN0_A_MTXA301_1","4lrh","Homo sapiens","FOLATE RECEPTOR ALPHA","PF03024(Folate_rec)",8,"TYR A  60;PHE A  62;ASP A  81;TYR A  85;GLN A 100;TRP A 102;ARG A 103;TRP A 171","FOL A 301 (-3.9A);None;FOL A 301 (-2.7A);FOL A 301 (-4.1A);FOL A 301 (-4.3A);FOL A 301 (-4.2A);FOL A 301 (-3.2A);FOL A 301 (-3.7A)","0.68A","4kn0A-4lrhA:34.6","4kn0A-4lrhA:77.36"],["4KN0_A_MTXA301_1","4lrh","Homo sapiens","FOLATE RECEPTOR ALPHA","PF03024(Folate_rec)",9,"TYR A  60;PHE A  62;ASP A  81;TYR A  85;TRP A 102;ARG A 103;GLY A 137;TRP A 140;TRP A 171","FOL A 301 (-3.9A);None;FOL A 301 (-2.7A);FOL A 301 (-4.1A);FOL A 301 (-4.2A);FOL A 301 (-3.2A);FOL A 301 (-4.3A);FOL A 301 (-3.6A);FOL A 301 (-3.7A)","0.64A","4kn0A-4lrhA:34.6","4kn0A-4lrhA:77.36"],["4KN0_A_MTXA301_1","5ve3","Paraburkholderia phytofirmans","BPPRF","no annotation",5,"PHE B 332;ASP B 307;ARG B 290;ARG B 300;GLY B 299","None","1.31A","4kn0A-5ve3B:0.0","4kn0A-5ve3B:19.14"]]