SIMILAR PATTERNS OF AMINO ACIDS FOR 4KMZ_A_FOLA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kmz FOLATE RECEPTOR BETA

(Homo sapiens) 		PF03024
(Folate_rec) 		12 TYR A  76
TYR A 101
GLN A 116
SER A 117
TRP A 118
ARG A 122
PHE A 123
HIS A 151
ARG A 152
TRP A 154
TRP A 187
TYR A 191
 FOL  A 301 (-3.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-3.9A)
FOL  A 301 (-4.0A)
None
FOL  A 301 (-3.5A)
FOL  A 301 (-4.1A)
 0.00A 4kmzA-4kmzA:
40.1		 4kmzA-4kmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lrh FOLATE RECEPTOR
ALPHA

(Homo sapiens) 		PF03024
(Folate_rec) 		10 TYR A  60
TYR A  85
GLN A 100
SER A 101
TRP A 102
ARG A 106
HIS A 135
TRP A 138
TRP A 171
TYR A 175
 FOL  A 301 (-3.9A)
FOL  A 301 (-4.1A)
FOL  A 301 (-4.3A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.2A)
FOL  A 301 (-3.8A)
FOL  A 301 (-4.1A)
None
FOL  A 301 (-3.7A)
FOL  A 301 (-4.1A)
 0.49A 4kmzA-4lrhA:
35.2		 4kmzA-4lrhA:
77.36