SIMILAR PATTERNS OF AMINO ACIDS FOR 4KMU_C_RFPC1401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		5 ASP A 152
HIS A 153
SER A 451
PRO A 114
ILE A 112
 None
 1.46A 4kmuC-1h3gA:
undetectable		 4kmuC-1h3gA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		5 GLN A 306
ASP A  81
LEU A 328
ILE A 301
ARG A  82
 None
 1.26A 4kmuC-1k25A:
0.0		 4kmuC-1k25A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s58 B19 PARVOVIRUS
CAPSID

(Primate
erythroparvovirus
1) 		PF00740
(Parvo_coat) 		5 GLN A 404
GLN A 383
HIS A 339
ASN A 350
ARG A 373
 None
 1.46A 4kmuC-1s58A:
undetectable		 4kmuC-1s58A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 GLN A 254
SER A 162
LEU A 227
PRO A 290
ILE A 258
 None
 1.47A 4kmuC-1z8lA:
0.0		 4kmuC-1z8lA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE

(Desulfovibrio
gigas) 		no annotation 5 GLN L 417
ASP L 107
HIS L 108
SER L 374
ARG L 296
 None
 1.37A 4kmuC-2frvL:
0.0		 4kmuC-2frvL:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		5 GLN A 617
GLN A 188
ARG A 128
SER A 586
ASN A 588
 None
 1.43A 4kmuC-2g28A:
0.0		 4kmuC-2g28A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsc TRANSCRIPTIONAL
REGULATOR
RV1994C/MT2050

(Mycobacterium
tuberculosis) 		PF01022
(HTH_5) 		5 GLN A  39
ASP A  32
HIS A  43
LEU A  55
ILE A  26
 None
 1.19A 4kmuC-2jscA:
undetectable		 4kmuC-2jscA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		5 GLN A 155
ASP A 163
LEU A 146
PRO A 141
ILE A 144
 None
 1.40A 4kmuC-2olaA:
0.0		 4kmuC-2olaA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I

(Escherichia
coli) 		PF00365
(PFK) 		5 HIS A 249
ARG A 252
LEU A 176
PRO A  14
ILE A 126
 None
 1.28A 4kmuC-2pfkA:
undetectable		 4kmuC-2pfkA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 SER X 248
LEU X 256
PRO X 214
ILE X 260
ARG X 309
 None
 1.45A 4kmuC-2pmoX:
undetectable		 4kmuC-2pmoX:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLN A 783
ASP A 719
HIS A 747
SER A 553
LEU A 554
 ZN  A1157 ( 4.5A)
None
ZN  A1157 (-3.3A)
None
None
 1.34A 4kmuC-2qf7A:
4.2		 4kmuC-2qf7A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		5 SER A 594
LEU A 591
PRO A 552
ILE A 398
ARG A 402
 None
 1.38A 4kmuC-3ayxA:
undetectable		 4kmuC-3ayxA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 GLN A 807
ASP A 742
HIS A 771
SER A 576
LEU A 577
 None
None
MN  A2001 (-3.4A)
None
None
 1.39A 4kmuC-3bg9A:
undetectable		 4kmuC-3bg9A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		5 GLN A 230
ASP A 264
HIS A 265
LEU A 200
PRO A  81
 None
 1.27A 4kmuC-3cuxA:
1.6		 4kmuC-3cuxA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLN B 412
ASP B 415
HIS B 425
PRO B 459
ASN B 463
 None
 0.88A 4kmuC-3hkzB:
16.6		 4kmuC-3hkzB:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs3 RIBOSE OPERON
REPRESSOR

(Lactobacillus
acidophilus) 		PF13377
(Peripla_BP_3) 		5 ASP A 279
ARG A 315
SER A 317
LEU A 259
ILE A 275
 None
 1.30A 4kmuC-3hs3A:
undetectable		 4kmuC-3hs3A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		5 ASP A 203
LEU A 145
PRO A 153
ASN A 149
ILE A 197
 None
 1.43A 4kmuC-3m62A:
2.9		 4kmuC-3m62A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF02581
(TMP-TENI) 		5 ASP A  16
LEU A 214
PRO A 207
ILE A 201
ARG A  18
 None
 1.43A 4kmuC-3o63A:
undetectable		 4kmuC-3o63A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		5 HIS B 481
ARG B 484
LEU B 397
PRO B 209
ILE B 347
 F6P  B 980 (-4.1A)
F6P  B 980 (-3.4A)
None
None
None
 1.33A 4kmuC-3o8oB:
undetectable		 4kmuC-3o8oB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		5 SER L 601
LEU L 598
PRO L 559
ILE L 399
ARG L 403
 None
 1.36A 4kmuC-3rgwL:
undetectable		 4kmuC-3rgwL:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rzu STAM-BINDING PROTEIN

(Homo sapiens) 		PF01398
(JAB) 		5 ASP A 252
HIS A 410
LEU A 289
PRO A 249
ASN A 292
 None
 1.41A 4kmuC-3rzuA:
undetectable		 4kmuC-3rzuA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN

(Escherichia
coli) 		PF00374
(NiFeSe_Hases) 		5 SER L 580
LEU L 577
PRO L 538
ILE L 398
ARG L 402
 None
 1.42A 4kmuC-3uscL:
0.8		 4kmuC-3uscL:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxy PUTATIVE
UNCHARACTERIZED
PROTEIN CSYB

(Aspergillus
oryzae) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ASP A 198
ARG A 194
LEU A  29
ARG A  63
ILE A  37
 None
 1.47A 4kmuC-3wxyA:
undetectable		 4kmuC-3wxyA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		5 SER A 583
LEU A 580
PRO A 541
ILE A 401
ARG A 405
 None
 1.42A 4kmuC-4c3oA:
1.2		 4kmuC-4c3oA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx6 PYRUVATE CARBOXYLASE

(Rhizobium etli) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 GLN A 783
ASP A 719
HIS A 747
SER A 553
LEU A 554
 ZN  A1102 ( 4.7A)
None
KCX  A 718 (-3.2A)
None
None
 1.34A 4kmuC-4jx6A:
undetectable		 4kmuC-4jx6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		6 GLN B 425
ASP B 428
HIS B 438
ARG B 441
PRO B 472
ASN B 476
 None
 0.88A 4kmuC-4qiwB:
19.6		 4kmuC-4qiwB:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		6 GLN B 425
HIS B 438
ARG B 441
ARG B 448
PRO B 472
ASN B 476
 None
 1.32A 4kmuC-4qiwB:
19.6		 4kmuC-4qiwB:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N) 		5 GLN A  60
ASP A  95
SER A 220
LEU A 248
ILE A 218
 None
None
SO4  A 302 (-4.0A)
None
None
 1.41A 4kmuC-4twbA:
undetectable		 4kmuC-4twbA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		5 GLN A 829
ASP A 727
ARG A 752
SER A 817
LEU A 828
 None
 1.37A 4kmuC-4zhjA:
2.0		 4kmuC-4zhjA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj5 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycolicibacterium
thermoresistibile) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 ASP A 378
HIS A 281
SER A 365
LEU A 361
ILE A 366
 None
 1.28A 4kmuC-5cj5A:
undetectable		 4kmuC-5cj5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		5 GLN A 314
SER A 319
LEU A 315
PRO A 222
ILE A 321
 None
 1.43A 4kmuC-5d4kA:
undetectable		 4kmuC-5d4kA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		5 SER A 319
LEU A 315
PRO A 222
ILE A 321
ARG A  43
 None
 1.45A 4kmuC-5d4kA:
undetectable		 4kmuC-5d4kA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		5 ASP A 403
SER A 371
LEU A 368
PRO A 418
ILE A 407
 None
 1.29A 4kmuC-5fhzA:
undetectable		 4kmuC-5fhzA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ASP A 739
SER A 610
LEU A 617
PRO A 751
ILE A 613
 None
 1.35A 4kmuC-5gz4A:
undetectable		 4kmuC-5gz4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		5 GLN A   7
SER A  66
LEU A  78
ASN A  70
ILE A  65
 None
 1.45A 4kmuC-5i98A:
undetectable		 4kmuC-5i98A:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr4 GDNF FAMILY RECEPTOR
ALPHA-2

(Homo sapiens) 		no annotation 5 ASP C 304
LEU C 220
ASN C 308
ILE C 237
ARG C 197
 None
 1.29A 4kmuC-5mr4C:
undetectable		 4kmuC-5mr4C:
4.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		10 GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
ARG C 456
PRO C 480
ASN C 484
ILE C 488
 None
 0.93A 4kmuC-5tw1C:
39.7		 4kmuC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		10 GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
ARG C 604
 None
 1.16A 4kmuC-5tw1C:
39.7		 4kmuC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		10 GLN C 426
GLN C 429
HIS C 442
ARG C 445
SER C 447
LEU C 449
ARG C 456
PRO C 480
ASN C 484
ILE C 488
 None
 0.94A 4kmuC-5tw1C:
39.7		 4kmuC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		10 GLN C 426
GLN C 429
HIS C 442
ARG C 445
SER C 447
LEU C 449
PRO C 480
ASN C 484
ILE C 488
ARG C 604
 None
 1.19A 4kmuC-5tw1C:
39.7		 4kmuC-5tw1C:
45.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 5 ASP C1566
SER C1597
LEU C1627
ILE C1601
ARG C1567
 None
 1.30A 4kmuC-5x6oC:
undetectable		 4kmuC-5x6oC:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLN B 474
HIS B 487
ARG B 490
ARG B 497
PRO B 521
 A  P   7 ( 3.9A)
None
G  P   8 ( 4.7A)
A  P   7 ( 4.9A)
G  P   8 ( 4.9A)
 0.85A 4kmuC-5xogB:
24.7		 4kmuC-5xogB:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnf PHOSPHOETHANOLAMINE
TRANSFERASE

(Moraxella sp.
HMSC061H09) 		no annotation 5 GLN A 373
GLN A 375
ASP A 406
ARG A 356
ILE A 421
 None
 1.48A 4kmuC-6bnfA:
undetectable		 4kmuC-6bnfA:
4.57