SIMILAR PATTERNS OF AMINO ACIDS FOR 4KLR_B_CHDB504_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		3 LEU A 410
PRO A 411
ARG A  39
 None
None
3PG  A 423 (-2.7A)
 0.59A 4klrB-13pkA:
1.5		 4klrB-13pkA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE

(Human
alphaherpesvirus
2) 		PF00716
(Peptidase_S21) 		3 LEU A  55
PRO A  56
ARG A 157
 None
None
DFP  A 300 ( 3.9A)
 0.57A 4klrB-1at3A:
undetectable		 4klrB-1at3A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 LEU A  40
PRO A  41
ARG A  49
 None
 0.67A 4klrB-1bt2A:
undetectable		 4klrB-1bt2A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		3 LEU A 819
PRO A 820
ARG A 854
 None
 0.61A 4klrB-1c7tA:
undetectable		 4klrB-1c7tA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H

(Streptomyces
plicatus) 		PF00704
(Glyco_hydro_18) 		3 LEU A  79
PRO A  78
ARG A 269
 LEU  A  79 ( 0.6A)
PRO  A  78 ( 1.1A)
ARG  A 269 ( 0.6A)
 0.66A 4klrB-1c8xA:
undetectable		 4klrB-1c8xA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmv HUMAN
CYTOMEGALOVIRUS
PROTEASE

(Human
betaherpesvirus
5) 		PF00716
(Peptidase_S21) 		3 LEU A  57
PRO A  58
ARG A 166
 None
 0.57A 4klrB-1cmvA:
undetectable		 4klrB-1cmvA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		3 LEU A 361
PRO A 362
ARG A  76
 None
 0.66A 4klrB-1dgmA:
2.2		 4klrB-1dgmA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0c SULFURTRANSFERASE

(Azotobacter
vinelandii) 		PF00581
(Rhodanese) 		3 LEU A   7
PRO A   8
ARG A 125
 None
 0.49A 4klrB-1e0cA:
2.1		 4klrB-1e0cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbz CATALASE

(Micrococcus
luteus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 LEU A 190
PRO A 191
ARG A 162
 None
 0.72A 4klrB-1hbzA:
undetectable		 4klrB-1hbzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdi PHOSPHOGLYCERATE
KINASE

(Sus scrofa) 		PF00162
(PGK) 		3 LEU A 407
PRO A 408
ARG A  38
 None
None
3PG  A 419 (-2.4A)
 0.42A 4klrB-1hdiA:
2.0		 4klrB-1hdiA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzm DUAL SPECIFICITY
PROTEIN PHOSPHATASE
6

(Homo sapiens) 		PF00581
(Rhodanese) 		3 LEU A  71
PRO A  72
ARG A  40
 None
 0.72A 4klrB-1hzmA:
undetectable		 4klrB-1hzmA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jih DNA POLYMERASE ETA

(Saccharomyces
cerevisiae) 		PF00817
(IMS)
PF11799
(IMS_C) 		3 LEU A 322
PRO A 323
ARG A 379
 None
 0.75A 4klrB-1jihA:
undetectable		 4klrB-1jihA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		3 LEU A  82
PRO A  83
ARG A 357
 None
 0.75A 4klrB-1jkmA:
4.3		 4klrB-1jkmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		3 LEU A 493
PRO A 494
ARG A 113
 None
 0.72A 4klrB-1jmzA:
undetectable		 4klrB-1jmzA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LEU A  82
PRO A  83
ARG A  59
 None
 0.43A 4klrB-1mdfA:
undetectable		 4klrB-1mdfA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5d CARBONYL
REDUCTASE/20BETA-HYD
ROXYSTEROID
DEHYDROGENASE

(Sus scrofa) 		PF00106
(adh_short) 		3 LEU A 256
PRO A 257
ARG A 212
 None
 0.65A 4klrB-1n5dA:
2.7		 4klrB-1n5dA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		3 LEU A 214
PRO A 215
ARG A 149
 None
None
SF4  A 500 (-4.5A)
 0.44A 4klrB-1oltA:
undetectable		 4klrB-1oltA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmi PHOSPHOMANNOSE
ISOMERASE

(Candida
albicans) 		PF01238
(PMI_typeI) 		3 LEU A  95
PRO A  96
ARG A 436
 None
 0.68A 4klrB-1pmiA:
undetectable		 4klrB-1pmiA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb3 CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01111
(CKS) 		3 LEU A  46
PRO A  47
ARG A  18
 None
 0.71A 4klrB-1qb3A:
undetectable		 4klrB-1qb3A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)

(Rattus
norvegicus) 		PF00149
(Metallophos) 		3 LEU A 300
PRO A 301
ARG A 206
 None
 0.68A 4klrB-1qfcA:
undetectable		 4klrB-1qfcA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhq PROTEIN (AURACYANIN)

(Chloroflexus
aurantiacus) 		PF00127
(Copper-bind) 		3 LEU A  37
PRO A  38
ARG A  44
 None
None
SO4  A 143 (-3.4A)
 0.72A 4klrB-1qhqA:
undetectable		 4klrB-1qhqA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)
RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (SMALL CHAIN)

(Synechococcus
elongatus;
Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
no annotation 		3 LEU M  18
PRO M  19
ARG A 435
 None
 0.65A 4klrB-1rblM:
undetectable		 4klrB-1rblM:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND

(Mycobacterium
tuberculosis) 		PF01436
(NHL) 		3 LEU A 228
PRO A 229
ARG A 245
 None
 0.62A 4klrB-1rwlA:
undetectable		 4klrB-1rwlA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbx SKI ONCOGENE

(Homo sapiens) 		PF02437
(Ski_Sno) 		3 LEU A 167
PRO A 168
ARG A 152
 None
 0.69A 4klrB-1sbxA:
undetectable		 4klrB-1sbxA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT
RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN

(Halothiobacillus
neapolitanus;
Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
PF00101
(RuBisCO_small) 		3 LEU M  19
PRO M  20
ARG A 428
 None
 0.61A 4klrB-1svdM:
undetectable		 4klrB-1svdM:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6z HYPOTHETICAL PROTEIN
TTHA0657

(Thermus
thermophilus) 		PF04452
(Methyltrans_RNA) 		3 LEU A  15
PRO A  16
ARG A   5
 None
 0.68A 4klrB-1v6zA:
3.0		 4klrB-1v6zA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xss FLUORESCENT PROTEIN

(Favia favus) 		PF01353
(GFP) 		3 LEU A  50
PRO A  51
ARG A 122
 None
 0.64A 4klrB-1xssA:
undetectable		 4klrB-1xssA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A

(Homo sapiens) 		PF00782
(DSPc) 		3 LEU A   9
PRO A  10
ARG A 147
 None
 0.59A 4klrB-1yz4A:
2.0		 4klrB-1yz4A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		3 LEU A  59
PRO A  58
ARG A 222
 None
 0.73A 4klrB-1zzmA:
undetectable		 4klrB-1zzmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4k 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		3 LEU A 190
PRO A 191
ARG A 239
 None
 0.70A 4klrB-2a4kA:
3.7		 4klrB-2a4kA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au3 DNA PRIMASE

(Aquifex
aeolicus) 		PF01807
(zf-CHC2)
PF08275
(Toprim_N)
PF13155
(Toprim_2) 		3 LEU A 321
PRO A 322
ARG A 256
 None
 0.73A 4klrB-2au3A:
5.2		 4klrB-2au3A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE

(Pyrococcus
horikoshii) 		PF00162
(PGK) 		3 LEU A 392
PRO A 393
ARG A  34
 None
None
3PG  A 503 (-2.9A)
 0.62A 4klrB-2cunA:
2.9		 4klrB-2cunA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		3 LEU A  68
PRO A  69
ARG A 214
 None
 0.58A 4klrB-2dc0A:
undetectable		 4klrB-2dc0A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu2 ASPA PROTEIN

(Rattus
norvegicus) 		PF04952
(AstE_AspA) 		3 LEU A 149
PRO A 150
ARG A 187
 None
 0.68A 4klrB-2gu2A:
3.2		 4klrB-2gu2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw3 KAEDE

(Trachyphyllia
geoffroyi) 		PF01353
(GFP) 		3 LEU A  50
PRO A  51
ARG A 119
 None
 0.60A 4klrB-2gw3A:
undetectable		 4klrB-2gw3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw4 KAEDE
KAEDE

(Trachyphyllia
geoffroyi;
Trachyphyllia
geoffroyi) 		PF01353
(GFP)
PF01353
(GFP) 		3 LEU A  50
PRO A  51
ARG B 119
 None
 0.62A 4klrB-2gw4A:
undetectable		 4klrB-2gw4A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1i CARBOXYLESTERASE

(Bacillus cereus) 		PF02230
(Abhydrolase_2) 		3 LEU A  31
PRO A  32
ARG A  47
 None
 0.74A 4klrB-2h1iA:
2.4		 4klrB-2h1iA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx5 HYPOTHETICAL PROTEIN

(Prochlorococcus
marinus) 		PF13279
(4HBT_2) 		3 LEU A  66
PRO A  67
ARG A  93
 ETX  A 153 (-4.5A)
ETX  A 153 ( 4.4A)
None
 0.73A 4klrB-2hx5A:
undetectable		 4klrB-2hx5A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jd4 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		3 LEU A2826
PRO A2827
ARG A2833
 None
 0.72A 4klrB-2jd4A:
undetectable		 4klrB-2jd4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbn CONSERVED PROTEIN

(Methanosarcina
mazei) 		no annotation 3 LEU A  58
PRO A  59
ARG A  70
 None
 0.67A 4klrB-2kbnA:
undetectable		 4klrB-2kbnA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9j MATRIX PROTEIN 2-1

(Human
orthopneumovirus) 		PF06436
(Pneumovirus_M2) 		3 LEU A 152
PRO A 153
ARG A 126
 None
 0.69A 4klrB-2l9jA:
undetectable		 4klrB-2l9jA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mi6 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSG

(Mycobacterium
tuberculosis) 		no annotation 3 LEU A  25
PRO A  26
ARG A  48
 None
 0.75A 4klrB-2mi6A:
undetectable		 4klrB-2mi6A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 LEU A 487
PRO A 488
ARG A 532
 None
 0.60A 4klrB-2nyaA:
1.6		 4klrB-2nyaA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 343
PRO A 342
ARG A 376
 None
 0.72A 4klrB-2og9A:
undetectable		 4klrB-2og9A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		3 LEU A 382
PRO A 377
ARG A 532
 None
 0.69A 4klrB-2pggA:
undetectable		 4klrB-2pggA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		3 LEU A  23
PRO A  24
ARG A 280
 None
 0.57A 4klrB-2q7sA:
undetectable		 4klrB-2q7sA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A  13
PRO A  14
ARG A 337
 None
 0.67A 4klrB-2qddA:
3.7		 4klrB-2qddA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp4 BILE SALT
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 LEU A 100
PRO A 101
ARG A  24
 None
 0.68A 4klrB-2qp4A:
undetectable		 4klrB-2qp4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsx PUTATIVE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio
parahaemolyticus) 		PF03466
(LysR_substrate) 		3 LEU A 158
PRO A 159
ARG A 169
 None
 0.57A 4klrB-2qsxA:
undetectable		 4klrB-2qsxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r09 CYTOHESIN-3

(Mus musculus) 		PF00169
(PH)
PF01369
(Sec7) 		3 LEU A 158
PRO A 159
ARG A 391
 None
 0.58A 4klrB-2r09A:
undetectable		 4klrB-2r09A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra9 UNCHARACTERIZED
PROTEIN DUF1285

(Shewanella
baltica) 		PF06938
(DUF1285) 		3 LEU A 127
PRO A 128
ARG A  93
 None
 0.64A 4klrB-2ra9A:
undetectable		 4klrB-2ra9A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va8 SKI2-TYPE HELICASE

(Sulfolobus
solfataricus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LEU A   8
PRO A   9
ARG A  19
 None
 0.62A 4klrB-2va8A:
4.2		 4klrB-2va8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		3 LEU A  61
PRO A  62
ARG A 426
 None
 0.74A 4klrB-2vgiA:
2.2		 4klrB-2vgiA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		3 LEU A 167
PRO A 168
ARG A 180
 None
 0.65A 4klrB-2vwbA:
undetectable		 4klrB-2vwbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 LEU A 320
PRO A 319
ARG A 274
 None
 0.75A 4klrB-2vz9A:
undetectable		 4klrB-2vz9A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5o ALPHA-L-ARABINOFURAN
OSIDASE

(Fusarium
graminearum) 		no annotation 3 LEU A 359
PRO A 360
ARG A 223
 None
None
AHR  A 500 (-3.9A)
 0.62A 4klrB-2w5oA:
undetectable		 4klrB-2w5oA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 LEU A 369
PRO A 370
ARG A  53
 None
 0.55A 4klrB-2wekA:
2.9		 4klrB-2wekA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 LEU A  92
PRO A  93
ARG A 405
 None
 0.60A 4klrB-2wvgA:
2.5		 4klrB-2wvgA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A

(Homo sapiens) 		PF02373
(JmjC) 		3 LEU A 471
PRO A 472
ARG A 325
 None
 0.71A 4klrB-2yu1A:
undetectable		 4klrB-2yu1A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2b DIHYDROOROTASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		3 LEU A 295
PRO A 296
ARG A  59
 None
 0.59A 4klrB-2z2bA:
undetectable		 4klrB-2z2bA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Thermus
thermophilus) 		PF01063
(Aminotran_4) 		3 LEU A 100
PRO A 101
ARG A 110
 None
 0.65A 4klrB-2zgiA:
undetectable		 4klrB-2zgiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adf MONOMERIC AZAMI
GREEN

(Galaxea
fascicularis) 		PF01353
(GFP) 		3 LEU A  50
PRO A  51
ARG A 119
 None
 0.67A 4klrB-3adfA:
undetectable		 4klrB-3adfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 LEU B 393
PRO B 394
ARG B 374
 None
 0.60A 4klrB-3amjB:
undetectable		 4klrB-3amjB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		3 LEU A  58
PRO A  59
ARG A   2
 None
 0.58A 4klrB-3auoA:
undetectable		 4klrB-3auoA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6e INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF04851
(ResIII) 		3 LEU A 481
PRO A 482
ARG A 459
 None
 0.55A 4klrB-3b6eA:
2.6		 4klrB-3b6eA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		3 LEU A 348
PRO A 349
ARG A 267
 None
 0.75A 4klrB-3bn1A:
undetectable		 4klrB-3bn1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 3 LEU A  65
PRO A  66
ARG A  52
 None
 0.66A 4klrB-3cv3A:
3.6		 4klrB-3cv3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb2 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Rhodopseudomonas
palustris) 		PF00701
(DHDPS) 		3 LEU A  12
PRO A  44
ARG A  73
 None
 0.71A 4klrB-3eb2A:
undetectable		 4klrB-3eb2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efe THIJ/PFPI FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01965
(DJ-1_PfpI) 		3 LEU A 168
PRO A 167
ARG A  30
 None
 0.59A 4klrB-3efeA:
undetectable		 4klrB-3efeA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		3 LEU A 805
PRO A 806
ARG A 653
 None
 0.73A 4klrB-3egiA:
undetectable		 4klrB-3egiA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eof PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF00881
(Nitroreductase) 		3 LEU A 200
PRO A 201
ARG A   9
 None
 0.60A 4klrB-3eofA:
undetectable		 4klrB-3eofA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ge9 THYMIDYLATE SYNTHASE
THYX

(Corynebacterium
glutamicum) 		PF02511
(Thy1) 		3 LEU A 175
PRO A 176
ARG A 182
 None
 0.72A 4klrB-3ge9A:
undetectable		 4klrB-3ge9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gov MASP-1

(Homo sapiens) 		PF00089
(Trypsin) 		3 LEU B 573
PRO B 574
ARG B 693
 None
 0.54A 4klrB-3govB:
undetectable		 4klrB-3govB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 LEU A 959
PRO A 960
ARG A1026
 None
 0.52A 4klrB-3h0gA:
undetectable		 4klrB-3h0gA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		3 LEU A 174
PRO A 175
ARG A 154
 None
 0.68A 4klrB-3h3zA:
undetectable		 4klrB-3h3zA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 LEU A 438
PRO A 439
ARG A 465
 None
 0.73A 4klrB-3hjrA:
1.5		 4klrB-3hjrA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hri HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		3 LEU A 376
PRO A 377
ARG A  57
 None
 0.48A 4klrB-3hriA:
undetectable		 4klrB-3hriA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 3 LEU A  86
PRO A  87
ARG A  70
 None
 0.62A 4klrB-3hwpA:
undetectable		 4klrB-3hwpA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzg THYMIDYLATE SYNTHASE
THYX

(Mycobacterium
tuberculosis) 		PF02511
(Thy1) 		3 LEU A 175
PRO A 176
ARG A 182
 None
 0.62A 4klrB-3hzgA:
undetectable		 4klrB-3hzgA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus;
Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		3 LEU 1 393
PRO 1 392
ARG 3 101
 None
 0.53A 4klrB-3i9v1:
2.2		 4klrB-3i9v1:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ide CAPSID PROTEIN VP2

(Infectious
pancreatic
necrosis virus) 		PF01766
(Birna_VP2) 		3 LEU A  16
PRO A  17
ARG A 423
 None
 0.75A 4klrB-3ideA:
undetectable		 4klrB-3ideA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jze DIHYDROOROTASE

(Salmonella
enterica) 		PF01979
(Amidohydro_1) 		3 LEU A 306
PRO A 307
ARG A  60
 None
 0.75A 4klrB-3jzeA:
undetectable		 4klrB-3jzeA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6r PUTATIVE TRANSFERASE
PH0793

(Pyrococcus
horikoshii) 		PF02475
(Met_10) 		3 LEU A  39
PRO A  40
ARG A  11
 None
 0.73A 4klrB-3k6rA:
2.2		 4klrB-3k6rA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kal HOMOGLUTATHIONE
SYNTHETASE

(Glycine max) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		3 LEU A  76
PRO A  77
ARG A 153
 None
None
HGS  A 501 ( 2.8A)
 0.61A 4klrB-3kalA:
undetectable		 4klrB-3kalA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		3 LEU A 334
PRO A 335
ARG A 478
 None
 0.70A 4klrB-3m8uA:
undetectable		 4klrB-3m8uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msv NUCLEAR IMPORT
ADAPTOR, NRO1

(Schizosaccharomyces
pombe) 		PF12753
(Nro1) 		3 LEU A 112
PRO A 113
ARG A 101
 None
 0.68A 4klrB-3msvA:
undetectable		 4klrB-3msvA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases) 		3 LEU B1418
PRO B1419
ARG B1274
 None
 0.53A 4klrB-3myrB:
undetectable		 4klrB-3myrB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		3 LEU A 225
PRO A 226
ARG A 307
 None
 0.61A 4klrB-3n6nA:
undetectable		 4klrB-3n6nA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbk PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		3 LEU A 144
PRO A 145
ARG A 155
 None
 0.69A 4klrB-3nbkA:
3.3		 4klrB-3nbkA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omx CG14216

(Drosophila
melanogaster) 		PF04722
(Ssu72) 		3 LEU A  45
PRO A  46
ARG A  88
 None
 0.73A 4klrB-3omxA:
5.2		 4klrB-3omxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		3 LEU A 227
PRO A 228
ARG A 354
 None
 0.18A 4klrB-3q3qA:
undetectable		 4klrB-3q3qA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbn DNA MISMATCH REPAIR
PROTEIN MLH1

(Homo sapiens) 		PF16413
(Mlh1_C) 		3 LEU A 172
PRO A 173
ARG A 220
 None
 0.74A 4klrB-3rbnA:
undetectable		 4klrB-3rbnA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3riq TAILSPIKE PROTEIN

(Salmonella
virus 9NA) 		PF09251
(PhageP22-tail) 		3 LEU A 265
PRO A 266
ARG A 247
 None
 0.62A 4klrB-3riqA:
undetectable		 4klrB-3riqA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3riq TAILSPIKE PROTEIN

(Salmonella
virus 9NA) 		PF09251
(PhageP22-tail) 		3 LEU A 436
PRO A 437
ARG A 354
 None
 0.59A 4klrB-3riqA:
undetectable		 4klrB-3riqA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmv GLYCOGENIN-1

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		3 LEU A 246
PRO A 243
ARG A 216
 None
 0.61A 4klrB-3rmvA:
undetectable		 4klrB-3rmvA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		3 LEU A 266
PRO A 267
ARG A 273
 None
 0.56A 4klrB-3ubdA:
undetectable		 4klrB-3ubdA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		3 LEU A 117
PRO A 118
ARG A 172
 None
 0.75A 4klrB-3ue9A:
undetectable		 4klrB-3ue9A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		3 LEU A 741
PRO A 742
ARG A 429
 None
 0.63A 4klrB-3wfzA:
undetectable		 4klrB-3wfzA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		3 LEU A 134
PRO A 135
ARG A 143
 None
 0.69A 4klrB-3wrcA:
undetectable		 4klrB-3wrcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zul FLUORESCENT PROTEIN
DRONPA

(Echinophyllia
sp. SC22) 		PF01353
(GFP) 		3 LEU A  50
PRO A  51
ARG A 119
 None
 0.73A 4klrB-3zulA:
undetectable		 4klrB-3zulA:
21.84