SIMILAR PATTERNS OF AMINO ACIDS FOR 4KLR_A_CHDA504_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aw9 GLUTATHIONE
S-TRANSFERASE III

(Zea mays) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 119
PRO A 212
VAL A  16
MET A   9
 None
 1.27A 4klrA-1aw9A:
undetectable		 4klrA-1aw9A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcu FRUCTOSE-1,6-BISPHOS
PHATASE

(Pisum sativum) 		PF00316
(FBPase) 		4 LEU A 273
ARG A 338
ARG A 301
VAL A 111
 None
 1.26A 4klrA-1dcuA:
undetectable		 4klrA-1dcuA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 459
ARG A 157
PRO A 367
SER A 370
 None
 1.03A 4klrA-1gycA:
0.0		 4klrA-1gycA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 LEU A1272
ARG A1269
PRO A1412
VAL A1409
 None
 1.12A 4klrA-1ihmA:
undetectable		 4klrA-1ihmA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		4 LEU A  93
ARG A 122
PRO A  88
VAL A  84
 None
 1.23A 4klrA-1ixpA:
1.1		 4klrA-1ixpA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lb3 FERRITIN LIGHT CHAIN
1

(Mus musculus) 		PF00210
(Ferritin) 		4 LEU A 110
PRO A  88
SER A  89
VAL A  85
 None
 1.11A 4klrA-1lb3A:
0.0		 4klrA-1lb3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh9 ACETYLGLUTAMATE
KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 LEU A 176
ARG A 226
SER A 180
VAL A 216
 None
None
ADP  A1259 (-4.6A)
None
 1.18A 4klrA-1oh9A:
3.7		 4klrA-1oh9A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjw ENVELOPE PROTEIN

(Japanese
encephalitis
virus) 		PF02832
(Flavi_glycop_C) 		4 LEU A  35
PRO A  85
SER A  90
VAL A  64
 None
 1.09A 4klrA-1pjwA:
undetectable		 4klrA-1pjwA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 LEU A 698
ARG A 757
ARG A 691
SER A 657
 None
 1.26A 4klrA-1rw9A:
0.0		 4klrA-1rw9A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s58 B19 PARVOVIRUS
CAPSID

(Primate
erythroparvovirus
1) 		PF00740
(Parvo_coat) 		4 ARG A 502
ARG A 550
PRO A 512
VAL A 509
 None
 1.24A 4klrA-1s58A:
undetectable		 4klrA-1s58A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yoc HYPOTHETICAL PROTEIN
PA1835

(Pseudomonas
aeruginosa) 		PF14539
(DUF4442) 		4 LEU A  70
PRO A  88
VAL A 122
MET A  91
 None
 1.26A 4klrA-1yocA:
undetectable		 4klrA-1yocA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
furiosus) 		PF01470
(Peptidase_C15) 		4 LEU A 115
PRO A  61
VAL A  36
MET A   1
 None
 1.18A 4klrA-1z8wA:
4.8		 4klrA-1z8wA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 LEU B 158
PRO B  21
SER B  22
VAL B 116
 None
 1.24A 4klrA-2bg9B:
undetectable		 4klrA-2bg9B:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		4 ARG A  88
PRO A  24
SER A  25
VAL A  94
 None
 1.18A 4klrA-2cevA:
3.1		 4klrA-2cevA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbn HYPOTHETICAL PROTEIN
YBIU

(Escherichia
coli) 		PF07350
(DUF1479) 		4 LEU A 276
ARG A 258
PRO A 135
SER A 197
 None
 1.24A 4klrA-2dbnA:
undetectable		 4klrA-2dbnA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dws COPPER-CONTAINING
NITRITE REDUCTASE

(Rhodobacter
sphaeroides) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 LEU A 324
ARG A 203
PRO A 190
VAL A  63
 None
 0.86A 4klrA-2dwsA:
undetectable		 4klrA-2dwsA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he4 NA(+)/H(+) EXCHANGE
REGULATORY COFACTOR
NHE-RF2

(Homo sapiens) 		PF00595
(PDZ) 		4 LEU A 165
ARG A 195
SER A 188
VAL A 228
 None
 1.18A 4klrA-2he4A:
undetectable		 4klrA-2he4A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE

(Salmonella
enterica) 		PF01263
(Aldose_epim) 		4 ARG A 227
PRO A 244
SER A 249
VAL A 264
 None
 1.19A 4klrA-2htbA:
undetectable		 4klrA-2htbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixd LMBE-RELATED PROTEIN

(Bacillus cereus) 		PF02585
(PIG-L) 		4 LEU A  72
ARG A  69
PRO A 104
VAL A  16
 None
 1.25A 4klrA-2ixdA:
2.7		 4klrA-2ixdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjd SODIUM/HYDROGEN
EXCHANGE REGULATORY
COFACTOR NHE-RF1

(Homo sapiens) 		PF00595
(PDZ)
PF09007
(EBP50_C) 		4 LEU A  26
ARG A  56
SER A  49
VAL A  89
 None
 1.24A 4klrA-2kjdA:
undetectable		 4klrA-2kjdA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvp TALIN-1

(Mus musculus) 		PF08913
(VBS) 		4 LEU A1923
ARG A1895
VAL A1866
MET A1871
 None
 1.25A 4klrA-2kvpA:
undetectable		 4klrA-2kvpA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6k TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE

(Homo sapiens) 		PF00017
(SH2) 		4 LEU A 106
PRO A  87
SER A  85
VAL A  78
 None
 1.19A 4klrA-2l6kA:
undetectable		 4klrA-2l6kA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nty EMB|CAB41934.1
RAC-LIKE GTP-BINDING
PROTEIN ARAC5

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF03759
(PRONE)
PF00071
(Ras) 		4 LEU C  73
ARG C  69
PRO A 207
MET A 204
 None
 1.10A 4klrA-2ntyC:
3.8		 4klrA-2ntyC:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozf EZRIN-RADIXIN-MOESIN
-BINDING
PHOSPHOPROTEIN 50

(Homo sapiens) 		PF00595
(PDZ) 		4 LEU A 168
ARG A 198
SER A 191
VAL A 231
 None
 0.93A 4klrA-2ozfA:
undetectable		 4klrA-2ozfA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q47 PROBABLE
TYROSINE-PROTEIN
PHOSPHATASE
AT1G05000

(Arabidopsis
thaliana) 		PF03162
(Y_phosphatase2) 		4 LEU A 139
ARG A 165
SER A  87
VAL A  62
 None
 1.00A 4klrA-2q47A:
undetectable		 4klrA-2q47A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt5 GLUTAMATE
RECEPTOR-INTERACTING
PROTEIN 1

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 LEU A 223
ARG A 167
PRO A 190
VAL A 185
 EDO  A   1 ( 4.3A)
None
None
None
 1.27A 4klrA-2qt5A:
undetectable		 4klrA-2qt5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3

(Mus musculus) 		PF03747
(ADP_ribosyl_GH) 		4 LEU A  36
ARG A 287
PRO A 320
SER A 322
 None
 0.76A 4klrA-2qtyA:
undetectable		 4klrA-2qtyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reu TYPE II RESTRICTION
ENZYME SAU3AI

(Staphylococcus
aureus) 		no annotation 4 ARG A 184
PRO A 228
SER A 230
VAL A 174
 None
 1.11A 4klrA-2reuA:
undetectable		 4klrA-2reuA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		4 LEU A 235
ARG A 225
SER A  15
VAL A  23
 None
ADP  A1400 (-3.3A)
None
None
 1.12A 4klrA-2v1uA:
undetectable		 4klrA-2v1uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 LEU A 211
PRO A 176
SER A 251
VAL A 179
 None
 0.99A 4klrA-2v9qA:
undetectable		 4klrA-2v9qA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A  49
PRO A 149
SER A 140
MET A 151
 None
 1.15A 4klrA-2vosA:
2.5		 4klrA-2vosA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5d PROBABLE
AMINOTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00155
(Aminotran_1_2) 		4 LEU A  41
PRO A 324
SER A 327
VAL A 321
 None
 1.08A 4klrA-2x5dA:
undetectable		 4klrA-2x5dA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		4 LEU A  89
ARG A 207
PRO A 732
VAL A 728
 None
 1.25A 4klrA-2yn9A:
2.4		 4klrA-2yn9A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zl5 58 KD CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 LEU A 272
ARG A 269
PRO A 412
VAL A 409
 None
 1.03A 4klrA-2zl5A:
undetectable		 4klrA-2zl5A:
23.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		6 LEU A 101
ARG A 114
PRO A 266
SER A 268
VAL A 305
MET A 308
 CHD  A   3 ( 4.9A)
CHD  A   2 (-3.6A)
CHD  A   2 ( 4.5A)
CHD  A   2 ( 4.4A)
CHD  A   1 ( 4.9A)
None
 0.91A 4klrA-3aqiA:
53.6		 4klrA-3aqiA:
99.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asp CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 LEU A 490
ARG A 270
PRO A 423
VAL A 420
 None
 1.10A 4klrA-3aspA:
undetectable		 4klrA-3aspA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		4 LEU A 271
ARG A 224
PRO A  41
SER A  42
 None
 1.23A 4klrA-3cq5A:
2.4		 4klrA-3cq5A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 LEU A 558
ARG A 532
ARG A 533
SER A 691
 None
 1.25A 4klrA-3e1sA:
2.0		 4klrA-3e1sA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		4 LEU A  90
ARG A  70
PRO A 123
SER A 169
 None
None
None
EDO  A1001 ( 4.5A)
 0.96A 4klrA-3e3xA:
undetectable		 4klrA-3e3xA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC

(Cytophaga
hutchinsonii) 		PF00266
(Aminotran_5) 		4 LEU A 135
ARG A 155
PRO A 174
SER A 170
 None
 1.20A 4klrA-3ffrA:
2.4		 4klrA-3ffrA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae) 		PF03583
(LIP) 		4 LEU A 233
PRO A  87
SER A 176
MET A 378
 None
 1.27A 4klrA-3h2iA:
2.6		 4klrA-3h2iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 117
PRO A 242
VAL A  44
MET A 239
 None
 1.25A 4klrA-3hi8A:
undetectable		 4klrA-3hi8A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htz ALANYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF01411
(tRNA-synt_2c) 		4 LEU A  28
ARG A 274
SER A  63
MET A  92
 None
 1.24A 4klrA-3htzA:
undetectable		 4klrA-3htzA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		4 LEU A 174
ARG A 134
SER A 105
VAL A  83
 None
 1.18A 4klrA-3ihaA:
undetectable		 4klrA-3ihaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtx AMINOTRANSFERASE

(Neisseria
meningitidis) 		PF00155
(Aminotran_1_2) 		4 LEU A  34
PRO A 322
SER A 325
VAL A 319
 None
 1.16A 4klrA-3jtxA:
undetectable		 4klrA-3jtxA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		4 ARG A  63
PRO A  18
SER A  20
VAL A 163
 None
 1.19A 4klrA-3ky9A:
undetectable		 4klrA-3ky9A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m33 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		no annotation 4 LEU A 105
ARG A  84
PRO A 118
SER A 120
 None
SO4  A 229 (-4.1A)
SO4  A 228 (-3.9A)
SO4  A 228 (-2.5A)
 1.27A 4klrA-3m33A:
2.3		 4klrA-3m33A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		4 LEU A 320
ARG A 414
PRO A  68
SER A  90
 None
 1.21A 4klrA-3p1vA:
4.1		 4klrA-3p1vA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		4 LEU A 221
ARG A 111
PRO A 206
VAL A 213
 None
 1.15A 4klrA-3qanA:
2.2		 4klrA-3qanA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 234
ARG A 214
PRO A 344
SER A 251
 None
 1.26A 4klrA-3sdqA:
undetectable		 4klrA-3sdqA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		4 ARG X 264
PRO X 277
VAL X 274
MET X 391
 None
PLP  X 502 ( 4.8A)
None
None
 1.22A 4klrA-3ss7X:
undetectable		 4klrA-3ss7X:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg9 PENICILLIN-BINDING
PROTEIN

(Bacillus
halodurans) 		PF00144
(Beta-lactamase) 		4 LEU A 247
ARG A 244
SER A 187
MET A 235
 None
 1.26A 4klrA-3tg9A:
undetectable		 4klrA-3tg9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8

(Homo sapiens) 		PF00076
(RRM_1)
PF13532
(2OG-FeII_Oxy_2) 		4 LEU A 152
ARG A 328
PRO A 221
VAL A 250
 None
AKG  A 403 (-3.2A)
None
None
 1.20A 4klrA-3thtA:
undetectable		 4klrA-3thtA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhu GLOBIN-1

(Scapharca
inaequivalvis) 		PF00042
(Globin) 		4 LEU A  73
ARG A  53
VAL A  57
MET A  61
 HEM  A 147 (-4.3A)
HEM  A 147 (-3.7A)
None
None
 1.18A 4klrA-3uhuA:
undetectable		 4klrA-3uhuA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 481
ARG A 178
PRO A 389
SER A 392
 None
 1.04A 4klrA-3x1bA:
undetectable		 4klrA-3x1bA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif PIX

(Bovine
mastadenovirus
B) 		PF03955
(Adeno_PIX) 		4 LEU N  75
PRO N  38
SER N  41
VAL N  23
 None
 1.25A 4klrA-3zifN:
undetectable		 4klrA-3zifN:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 117
ARG A 674
PRO A 176
SER A 174
 None
 1.26A 4klrA-3zz1A:
2.3		 4klrA-3zz1A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR BETA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 LEU B 158
PRO B  21
SER B  22
VAL B 116
 None
 1.24A 4klrA-4booB:
undetectable		 4klrA-4booB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU A 346
SER A 114
VAL A 133
MET A 136
 None
 1.25A 4klrA-4c41A:
undetectable		 4klrA-4c41A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LEU A  93
ARG A 140
PRO A  45
SER A  46
 None
 1.16A 4klrA-4cakA:
undetectable		 4klrA-4cakA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df9 PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		4 LEU A 320
ARG A 414
PRO A  68
SER A  90
 None
 1.26A 4klrA-4df9A:
4.0		 4klrA-4df9A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos) 		4 LEU A 154
PRO A 350
SER A 351
MET A 139
 None
 1.25A 4klrA-4fvaA:
undetectable		 4klrA-4fvaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE

(Thermothelomyces
thermophila) 		no annotation 4 LEU A 292
ARG A  66
SER A 248
VAL A 285
 None
 1.11A 4klrA-4g4iA:
undetectable		 4klrA-4g4iA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos)
PF14555
(UBA_4) 		4 LEU A 154
PRO A 350
SER A 351
MET A 139
 None
 1.23A 4klrA-4gewA:
undetectable		 4klrA-4gewA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		4 LEU A 390
ARG A 396
SER A 404
VAL A 478
 None
 1.19A 4klrA-4jo0A:
undetectable		 4klrA-4jo0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A  12
PRO A  91
SER A  58
VAL A 154
 None
 1.20A 4klrA-4k9qA:
2.6		 4klrA-4k9qA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A  15
PRO A  91
SER A  58
VAL A 154
 None
 1.21A 4klrA-4k9qA:
2.6		 4klrA-4k9qA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 LEU A 617
PRO A 439
SER A 440
VAL A 572
 None
 1.07A 4klrA-4kkdA:
undetectable		 4klrA-4kkdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		4 LEU A 422
ARG A 303
SER A 376
VAL A 358
 None
 1.17A 4klrA-4ldsA:
undetectable		 4klrA-4ldsA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ARG A1385
PRO A1354
SER A1292
MET A 740
 None
 1.23A 4klrA-4o9xA:
undetectable		 4klrA-4o9xA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Xanthobacter
autotrophicus) 		PF03480
(DctP) 		4 LEU A  51
ARG A 256
SER A  30
VAL A 138
 None
 1.21A 4klrA-4ovrA:
undetectable		 4klrA-4ovrA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4quk DIHYDROFLAVONOL-4-RE
DUCTASE

(Medicago
truncatula) 		PF01370
(Epimerase) 		4 PRO A 192
SER A 130
VAL A 231
MET A 194
 None
 1.15A 4klrA-4qukA:
2.4		 4klrA-4qukA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		4 LEU A 411
PRO A 367
SER A 388
VAL A 381
 None
 0.95A 4klrA-4s3jA:
undetectable		 4klrA-4s3jA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3k SPORE GERMINATION
PROTEIN YAAH

(Bacillus
megaterium) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		4 LEU A 411
PRO A 367
SER A 388
VAL A 381
 None
 0.99A 4klrA-4s3kA:
undetectable		 4klrA-4s3kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buk FADH2-DEPENDENT
HALOGENASE

(Streptomyces
sp. CNQ-418) 		PF04820
(Trp_halogenase) 		4 LEU A 128
ARG A  40
ARG A 122
VAL A 327
 None
FAD  A 501 (-3.8A)
FAD  A 501 (-3.0A)
FAD  A 501 (-3.7A)
 1.27A 4klrA-5bukA:
undetectable		 4klrA-5bukA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ARG A  42
PRO A 225
SER A 357
VAL A 221
 None
 1.12A 4klrA-5bz4A:
2.1		 4klrA-5bz4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		4 ARG A  72
ARG A 105
SER A 154
VAL A  80
 None
 1.26A 4klrA-5dbxA:
undetectable		 4klrA-5dbxA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6t CAPSID

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 LEU A 265
ARG A 262
PRO A 402
VAL A 399
 None
 1.04A 4klrA-5e6tA:
undetectable		 4klrA-5e6tA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 LEU A 355
ARG A 312
PRO A 297
SER A 322
 None
 1.07A 4klrA-5eawA:
2.1		 4klrA-5eawA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 457
ARG A 157
PRO A 369
SER A 372
 GOL  A 505 ( 4.9A)
None
None
None
 1.18A 4klrA-5ehfA:
undetectable		 4klrA-5ehfA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giv CARBOXYPEPTIDASE 1

(Deinococcus
radiodurans) 		PF02074
(Peptidase_M32) 		4 LEU A 355
ARG A 300
PRO A 196
VAL A 340
 None
 1.18A 4klrA-5givA:
undetectable		 4klrA-5givA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 4 LEU A 785
ARG A 834
SER A 754
VAL A 768
 None
IHP  A1201 (-3.7A)
None
None
 1.15A 4klrA-5hdtA:
undetectable		 4klrA-5hdtA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 LEU A 288
PRO A 746
SER A 664
VAL A 394
 None
 1.27A 4klrA-5hjrA:
undetectable		 4klrA-5hjrA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 ARG A 244
PRO A 215
SER A 286
MET A 263
 BLA  A 601 (-3.0A)
None
None
None
 1.03A 4klrA-5i5lA:
undetectable		 4klrA-5i5lA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		4 LEU A 541
ARG A 124
PRO A 318
SER A 370
 None
 1.07A 4klrA-5icqA:
undetectable		 4klrA-5icqA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 LEU C 155
ARG C  66
PRO C 132
VAL C 142
 None
 1.09A 4klrA-5ip7C:
undetectable		 4klrA-5ip7C:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz1 FRUCTOSE-1,6-BISPHOS
PHATASE

(Physcomitrella
patens) 		PF00316
(FBPase) 		4 LEU A 341
ARG A 406
ARG A 369
VAL A 182
 None
 1.24A 4klrA-5iz1A:
undetectable		 4klrA-5iz1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		4 LEU A 451
ARG A 240
PRO A 163
VAL A 491
 None
GOL  A 801 (-3.7A)
None
None
 1.05A 4klrA-5jjhA:
undetectable		 4klrA-5jjhA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG

(Homo sapiens) 		PF04821
(TIMELESS) 		4 LEU A 366
ARG A 406
SER A 215
MET A 358
 None
SO4  A1600 (-3.6A)
None
None
 1.19A 4klrA-5mqiA:
undetectable		 4klrA-5mqiA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ARG A1262
PRO A1149
SER A1152
VAL A1145
 None
 1.25A 4klrA-5ujaA:
undetectable		 4klrA-5ujaA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 4 ARG A 203
PRO A 263
SER A 265
VAL A 211
 None
 1.19A 4klrA-5vqdA:
3.2		 4klrA-5vqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		4 LEU O 942
ARG O 684
PRO O 989
VAL O 747
 None
 1.23A 4klrA-5x0yO:
undetectable		 4klrA-5x0yO:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2b SULFOTRANSFERASE

(Mus musculus) 		no annotation 4 LEU D  73
PRO D  46
SER D  44
VAL D 154
 None
None
A3P  D 301 ( 4.9A)
None
 1.13A 4klrA-5x2bD:
2.1		 4klrA-5x2bD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU B 411
ARG B 217
SER B 360
VAL B 406
 None
 1.09A 4klrA-5y58B:
3.4		 4klrA-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 4 LEU A 393
ARG A 316
ARG A 353
PRO A 426
 None
 0.99A 4klrA-5ykbA:
undetectable		 4klrA-5ykbA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k NETRIN RECEPTOR DCC

(Rattus
norvegicus) 		no annotation 4 LEU A  81
PRO A  46
SER A 129
VAL A 134
 None
 1.17A 4klrA-5z5kA:
undetectable		 4klrA-5z5kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zdh TYPE II SECRETION
SYSTEM PROTEIN D

(Escherichia
coli) 		no annotation 4 LEU A 522
PRO A 438
SER A 436
VAL A 325
 None
 1.12A 4klrA-5zdhA:
undetectable		 4klrA-5zdhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 4 LEU A 802
ARG A 854
PRO A 703
SER A 693
 None
 1.00A 4klrA-6cipA:
2.1		 4klrA-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 LEU A1137
PRO A1025
VAL A1022
MET A1453
 None
 1.18A 4klrA-6fb3A:
undetectable		 4klrA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3d ARGININOSUCCINATE
LYASE

(Chelativorans
sp. BNC1) 		no annotation 4 LEU A 128
ARG A 185
SER A 331
VAL A 247
 None
 1.27A 4klrA-6g3dA:
undetectable		 4klrA-6g3dA:
undetectable