SIMILAR PATTERNS OF AMINO ACIDS FOR 4KLA_A_CHDA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 LEU A 312
LEU A 307
LEU A 303
ILE A 330
VAL A 346
 None
 1.13A 4klaA-1bjwA:
0.5		 4klaA-1bjwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		4 LEU A 642
LEU A 639
LEU A 635
ILE A 682
 None
 0.74A 4klaA-1d5fA:
undetectable		 4klaA-1d5fA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcf ETR1 PROTEIN

(Arabidopsis
thaliana) 		PF00072
(Response_reg) 		4 LEU A 110
LEU A  89
ILE A 119
VAL A  10
 None
 0.86A 4klaA-1dcfA:
1.4		 4klaA-1dcfA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7r TRANSLATION
INITIATION FACTOR
IF2/EIF5B

(Methanothermobacter
thermautotrophicus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		4 LEU A  69
LEU A 224
ILE A  52
VAL A   8
 None
 0.84A 4klaA-1g7rA:
2.0		 4klaA-1g7rA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gdh D-GLYCERATE
DEHYDROGENASE

(Hyphomicrobium
methylovorum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 258
LEU A 253
LEU A 279
LYS A 227
ILE A 226
 None
 1.50A 4klaA-1gdhA:
3.6		 4klaA-1gdhA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR

(Homo sapiens) 		PF03261
(CDK5_activator) 		4 LEU D 152
LEU D 155
LEU D 159
ILE D 196
 None
 0.75A 4klaA-1h4lD:
undetectable		 4klaA-1h4lD:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		4 LEU A 127
LEU A 141
ILE A 110
VAL A  94
 None
 0.86A 4klaA-1h6uA:
undetectable		 4klaA-1h6uA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Aquifex
aeolicus) 		PF00885
(DMRL_synthase) 		4 LEU A 100
LEU A 103
LEU A 107
ILE A  59
 None
 0.86A 4klaA-1hqkA:
2.1		 4klaA-1hqkA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsj FUSION PROTEIN
CONSISTING OF
STAPHYLOCOCCUS
ACCESSORY REGULATOR
PROTEIN R AND
MALTOSE BINDING
PROTEIN

(Escherichia
coli;
Staphylococcus
aureus) 		PF01547
(SBP_bac_1) 		4 LEU A 441
LEU A 444
LEU A 449
ILE A 426
 None
 0.81A 4klaA-1hsjA:
undetectable		 4klaA-1hsjA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		4 LEU A 232
LEU A 279
ILE A  92
VAL A 285
 None
 0.72A 4klaA-1hvyA:
undetectable		 4klaA-1hvyA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqp RFCS

(Pyrococcus
furiosus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 LEU A  82
LEU A 116
LEU A 145
VAL A 141
 None
 0.76A 4klaA-1iqpA:
undetectable		 4klaA-1iqpA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 LEU A 285
LEU A 288
LEU A 213
ILE A 107
VAL A 135
 None
 1.39A 4klaA-1ir6A:
undetectable		 4klaA-1ir6A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdz 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfolobus
solfataricus) 		PF01048
(PNP_UDP_1) 		4 LEU A  28
LEU A  29
LEU A  18
VAL A 202
 None
 0.87A 4klaA-1jdzA:
3.3		 4klaA-1jdzA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsd HAEMAGGLUTININ (HA1
CHAIN)
HAEMAGGLUTININ (HA2
CHAIN)

(Influenza A
virus;
Influenza A
virus) 		PF00509
(Hemagglutinin)
PF00509
(Hemagglutinin) 		4 LEU A  32
LEU A 305
LYS B  51
ILE B  55
 None
 0.77A 4klaA-1jsdA:
undetectable		 4klaA-1jsdA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		5 LEU A 101
LEU A  92
LEU A  91
LYS A   2
ILE A   4
 None
 1.29A 4klaA-1kaqA:
undetectable		 4klaA-1kaqA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 LEU A 179
LEU A 176
ILE A 156
VAL A 165
 None
 0.62A 4klaA-1kblA:
undetectable		 4klaA-1kblA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 LEU A 219
LEU A 222
ILE A 204
HIS A 168
 None
 0.69A 4klaA-1khdA:
undetectable		 4klaA-1khdA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		7 MET A  46
LEU A  59
LEU A  62
LYS A  90
ILE A  91
HIS A 235
VAL A 277
 None
 0.75A 4klaA-1lbqA:
48.0		 4klaA-1lbqA:
49.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		5 MET A 102
LEU A 184
LEU A 152
LEU A 135
ILE A 208
 None
 1.11A 4klaA-1lc7A:
undetectable		 4klaA-1lc7A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		4 LEU A 304
ILE A 137
HIS A 148
VAL A 157
 None
 0.86A 4klaA-1m2pA:
undetectable		 4klaA-1m2pA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9s INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF09479
(Flg_new)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13457
(SH3_8) 		4 LEU A 119
LEU A 122
LEU A 144
ILE A  94
 None
 0.76A 4klaA-1m9sA:
undetectable		 4klaA-1m9sA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 LEU C 382
LEU C 407
LEU C 434
ILE C 349
 None
 0.84A 4klaA-1n8yC:
undetectable		 4klaA-1n8yC:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 LEU A 121
LEU A 118
LEU A 110
ILE A  68
 None
 0.88A 4klaA-1nnwA:
undetectable		 4klaA-1nnwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C) 		4 LEU E 939
LEU E 942
LEU E 892
ILE E 990
 None
 0.81A 4klaA-1o7dE:
undetectable		 4klaA-1o7dE:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 LEU A1488
LEU A1481
ILE A1452
VAL A1411
 None
 0.65A 4klaA-1ofeA:
1.3		 4klaA-1ofeA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A  83
LEU A 107
LEU A 129
ILE A  62
VAL A  72
 None
 1.08A 4klaA-1oznA:
undetectable		 4klaA-1oznA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 LEU B 210
LEU B 213
LEU B 218
ILE B 252
 None
 0.84A 4klaA-1pjmB:
undetectable		 4klaA-1pjmB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 333
LEU A 330
ILE A 204
VAL A 324
 None
 0.88A 4klaA-1pvdA:
undetectable		 4klaA-1pvdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1l CHORISMATE SYNTHASE

(Aquifex
aeolicus) 		PF01264
(Chorismate_synt) 		4 LEU A   6
LEU A 239
ILE A  26
VAL A 384
 None
 0.82A 4klaA-1q1lA:
undetectable		 4klaA-1q1lA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		4 LEU A 221
LEU A 224
LEU A 228
LYS A 384
 None
 0.86A 4klaA-1qb4A:
undetectable		 4klaA-1qb4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))
PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
PF13361
(UvrD_C) 		5 LEU D 617
LEU D 577
LEU D 564
ILE B 321
VAL B 299
 None
 1.27A 4klaA-1qhhD:
undetectable		 4klaA-1qhhD:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5p NAD-DEPENDENT
DEACETYLASE

(Escherichia
coli) 		PF02146
(SIR2) 		4 LEU A 113
LEU A 116
LEU A 120
ILE A 213
 None
 0.80A 4klaA-1s5pA:
undetectable		 4klaA-1s5pA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL

(Pyrobaculum
aerophilum) 		PF10432
(bact-PGI_C) 		4 LEU A 146
LEU A 142
ILE A 155
VAL A  68
 None
 0.85A 4klaA-1tzbA:
undetectable		 4klaA-1tzbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 LEU A 165
LEU A 161
ILE A 222
VAL A 357
 None
None
None
HEM  A1430 ( 4.9A)
 0.82A 4klaA-1uedA:
undetectable		 4klaA-1uedA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujo TRANSGELIN

(Mus musculus) 		PF00307
(CH) 		4 LEU A  46
LEU A  49
LEU A  53
VAL A  90
 None
 0.63A 4klaA-1ujoA:
undetectable		 4klaA-1ujoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ul1 FLAP ENDONUCLEASE-1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 LEU X 229
LEU X 226
LEU X 218
ILE X 241
 None
 0.80A 4klaA-1ul1X:
undetectable		 4klaA-1ul1X:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1

(Homo sapiens) 		PF03261
(CDK5_activator) 		4 LEU D 152
LEU D 155
LEU D 159
ILE D 196
 None
 0.57A 4klaA-1unlD:
undetectable		 4klaA-1unlD:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus
coagulans) 		PF00180
(Iso_dh) 		4 LEU A 251
LEU A 262
ILE A 229
VAL A 128
 None
 0.74A 4klaA-1v5bA:
undetectable		 4klaA-1v5bA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		4 LEU A  55
LEU A  52
LEU A  49
HIS A 312
 None
 0.85A 4klaA-1vbmA:
undetectable		 4klaA-1vbmA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm6 DIHYDRODIPICOLINATE
REDUCTASE

(Thermotoga
maritima) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		4 LEU A  86
LEU A  83
LEU A  75
VAL A   6
 None
 0.82A 4klaA-1vm6A:
undetectable		 4klaA-1vm6A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE

(Thermoproteus
tenax) 		PF00121
(TIM)
PF05690
(ThiG) 		4 LEU A 103
LEU A 106
LEU A  78
HIS A  45
 None
 0.88A 4klaA-1w0mA:
undetectable		 4klaA-1w0mA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE

(Sulfurisphaera
tokodaii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 MET A 130
LEU A 261
LEU A 264
ILE A 253
 None
 0.74A 4klaA-1wydA:
undetectable		 4klaA-1wydA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6

(Homo sapiens) 		PF00307
(CH) 		4 LEU A  45
LEU A  48
LEU A  52
VAL A  86
 None
 0.87A 4klaA-1wyrA:
undetectable		 4klaA-1wyrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		4 LEU A 256
LEU A 253
LEU A 249
ILE A  90
 None
 0.74A 4klaA-1xr5A:
undetectable		 4klaA-1xr5A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 LEU A 257
LEU A 254
LEU A 250
ILE A  90
 None
 0.89A 4klaA-1xr6A:
undetectable		 4klaA-1xr6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yav HYPOTHETICAL PROTEIN
BSU14130

(Bacillus
subtilis) 		no annotation 4 LEU A  42
LEU A  39
LEU A  83
VAL A  91
 None
 0.88A 4klaA-1yavA:
undetectable		 4klaA-1yavA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 LEU A 208
LEU A 212
LEU A 218
ILE A 204
 None
 0.74A 4klaA-1yrgA:
undetectable		 4klaA-1yrgA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ECDYSONE RECEPTOR
LIGAND BINDING
DOMAIN

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		4 LEU E 383
LEU E 380
LEU E 377
VAL E 320
 None
 0.83A 4klaA-1z5xE:
undetectable		 4klaA-1z5xE:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 LEU A 330
LEU A 331
LEU A 295
ILE A 370
 None
 0.87A 4klaA-1z6tA:
undetectable		 4klaA-1z6tA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		4 LEU A 190
LEU A 193
LEU A 199
ILE A 247
 None
 0.86A 4klaA-1zg4A:
undetectable		 4klaA-1zg4A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 LEU A 103
LEU A 106
LEU A 220
ILE A  93
VAL A 183
 None
 1.24A 4klaA-1zl6A:
undetectable		 4klaA-1zl6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 LEU A 100
LEU A 103
LEU A 107
ILE A  65
 None
 0.84A 4klaA-2aaaA:
undetectable		 4klaA-2aaaA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afe PROTEIN ASL1650

(Nostoc sp. PCC
7120) 		PF00550
(PP-binding) 		4 LEU A  54
LEU A  57
LEU A  61
ILE A  70
 None
 0.88A 4klaA-2afeA:
undetectable		 4klaA-2afeA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7h HEMOGLOBIN ALPHA
CHAIN

(Cerdocyon thous) 		PF00042
(Globin) 		4 LEU A 109
LEU A 105
LEU A 101
ILE A  17
 None
None
HEM  A 200 (-4.4A)
None
 0.87A 4klaA-2b7hA:
undetectable		 4klaA-2b7hA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbe HYPOTHETICAL PROTEIN
SO0527

(Shewanella
oneidensis) 		PF03992
(ABM) 		4 LEU A  37
LEU A  34
LEU A  30
ILE A  83
 None
 0.83A 4klaA-2bbeA:
undetectable		 4klaA-2bbeA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		4 LEU A 130
LEU A 127
ILE A 206
VAL A 243
 None
 0.86A 4klaA-2cy8A:
undetectable		 4klaA-2cy8A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dxb THIOCYANATE
HYDROLASE SUBUNIT
GAMMA

(Thiobacillus
thioparus) 		PF02979
(NHase_alpha) 		4 LEU C 168
LEU C 163
LEU C 155
VAL C 189
 None
 0.89A 4klaA-2dxbC:
undetectable		 4klaA-2dxbC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1k PREPHENATE
DEHYDROGENASE

(Synechocystis
sp. PCC 6803) 		PF02153
(PDH) 		4 LEU A 158
LEU A 155
LEU A 151
VAL A   5
 None
None
OCS  A 150 ( 4.6A)
None
 0.89A 4klaA-2f1kA:
2.1		 4klaA-2f1kA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Staphylococcus
aureus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 LEU B 170
LEU B 295
ILE B 151
VAL B 179
 None
 0.75A 4klaA-2f2aB:
undetectable		 4klaA-2f2aB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 154
LEU A  87
LEU A  88
ILE A  65
VAL A  24
 None
 1.37A 4klaA-2gl8A:
undetectable		 4klaA-2gl8A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		4 LEU A 250
LEU A 247
LEU A 243
VAL A 138
 None
 0.84A 4klaA-2go4A:
undetectable		 4klaA-2go4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 475
LEU A 479
ILE A 467
VAL A 517
 None
 0.85A 4klaA-2gv9A:
undetectable		 4klaA-2gv9A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gxa REPLICATION PROTEIN
E1

(Deltapapillomavirus
4) 		PF00519
(PPV_E1_C) 		4 LEU A 535
LEU A 496
ILE A 524
VAL A 477
 None
 0.82A 4klaA-2gxaA:
undetectable		 4klaA-2gxaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hek HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF01966
(HD) 		4 LEU A  83
LEU A  82
LEU A  56
ILE A 118
 None
 0.84A 4klaA-2hekA:
undetectable		 4klaA-2hekA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hh9 THIAMIN
PYROPHOSPHOKINASE

(Candida
albicans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 LEU A 173
LEU A 176
LEU A 180
ILE A 133
 None
 0.80A 4klaA-2hh9A:
undetectable		 4klaA-2hh9A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr7 INSULIN RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 LEU A  54
LEU A  79
LEU A 106
ILE A  29
 None
 0.88A 4klaA-2hr7A:
undetectable		 4klaA-2hr7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyp HYPOTHETICAL PROTEIN
RV0805

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		4 LEU A 149
LEU A 152
LEU A 156
VAL A 217
 None
 0.86A 4klaA-2hypA:
undetectable		 4klaA-2hypA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 469
LEU A 428
LEU A 474
VAL A 435
 None
 0.88A 4klaA-2i0eA:
undetectable		 4klaA-2i0eA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 LEU A 295
LEU A 298
LEU A 322
VAL A 287
 None
 0.80A 4klaA-2id5A:
undetectable		 4klaA-2id5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum) 		PF13247
(Fer4_11) 		4 LEU B 298
LEU B 301
LEU B 260
ILE B 293
 None
 0.84A 4klaA-2ivfB:
undetectable		 4klaA-2ivfB:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhe TRANSCRIPTION
REGULATOR TYRR

(Escherichia
coli) 		PF13188
(PAS_8) 		5 LEU A  28
LEU A  21
LEU A  54
ILE A  31
VAL A   5
 None
 1.41A 4klaA-2jheA:
undetectable		 4klaA-2jheA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A

(Mus musculus) 		PF14580
(LRR_9) 		4 LEU A  22
LEU A  47
LEU A  66
ILE A   7
 None
 0.84A 4klaA-2jqdA:
undetectable		 4klaA-2jqdA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llg UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF16729
(DUF5067) 		5 LEU A  29
LEU A  26
LEU A  24
ILE A 142
VAL A  67
 None
 1.43A 4klaA-2llgA:
undetectable		 4klaA-2llgA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 LEU A 107
LEU A 104
LEU A 180
ILE A 122
VAL A 176
 None
None
None
FAD  A 401 (-4.0A)
None
 1.49A 4klaA-2mbrA:
undetectable		 4klaA-2mbrA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myi EXODEOXYRIBONUCLEASE
III

(Pseudomonas sp.
Lz4W) 		PF03372
(Exo_endo_phos) 		4 LEU A  23
LEU A  20
ILE A  31
VAL A   8
 None
 0.88A 4klaA-2myiA:
undetectable		 4klaA-2myiA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2no5 (S)-2-HALOACID
DEHALOGENASE IVA

(Burkholderia
cepacia) 		PF13419
(HAD_2) 		4 LEU A 216
LEU A 219
LEU A 223
LYS A  12
 SO4  A1006 ( 3.4A)
None
None
ASL  A  11 ( 3.3A)
 0.82A 4klaA-2no5A:
2.8		 4klaA-2no5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ECDYSONE RECEPTOR
(ECR, NRH1)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		4 LEU E 514
LEU E 511
LEU E 508
VAL E 451
 None
 0.83A 4klaA-2nxxE:
undetectable		 4klaA-2nxxE:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 LEU A 197
LEU A 227
LEU A 221
ILE A 171
VAL A 212
 None
 1.44A 4klaA-2o4cA:
5.2		 4klaA-2o4cA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201

(Pseudomonas
aeruginosa) 		PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF) 		4 LEU A 180
LEU A 181
LEU A 109
ILE A 260
 None
 0.89A 4klaA-2oceA:
undetectable		 4klaA-2oceA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 LEU A 324
LEU A 346
LEU A 366
ILE A 310
 None
 0.88A 4klaA-2omvA:
undetectable		 4klaA-2omvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE

(Thermobifida
fusca) 		PF13378
(MR_MLE_C) 		4 LEU A  12
LEU A 261
LEU A 258
ILE A  19
 None
 0.88A 4klaA-2opjA:
undetectable		 4klaA-2opjA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ory LIPASE

(Photobacterium
sp. M37) 		PF01764
(Lipase_3) 		5 LEU A 187
LEU A 183
LYS A 159
ILE A 160
VAL A  75
 None
 1.48A 4klaA-2oryA:
undetectable		 4klaA-2oryA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ory LIPASE

(Photobacterium
sp. M37) 		PF01764
(Lipase_3) 		5 LEU A 195
LEU A 187
LEU A 183
ILE A 160
VAL A  75
 None
 1.46A 4klaA-2oryA:
undetectable		 4klaA-2oryA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oud DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A 404
LEU A 475
LYS A 371
ILE A 352
 None
 0.75A 4klaA-2oudA:
undetectable		 4klaA-2oudA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbk KSHV PROTEASE

(Human
gammaherpesvirus
8) 		PF00716
(Peptidase_S21) 		4 LEU A 110
LEU A 106
LEU A 102
ILE A  44
 None
None
ACT  A 602 (-4.0A)
None
 0.79A 4klaA-2pbkA:
undetectable		 4klaA-2pbkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 392
LEU A  56
ILE A  35
VAL A 439
 None
 0.86A 4klaA-2qo3A:
undetectable		 4klaA-2qo3A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpq PROTEIN BUG27

(Bordetella
pertussis) 		PF03401
(TctC) 		5 LEU A 199
LEU A 117
LEU A 149
LYS A 113
VAL A 131
 None
 1.47A 4klaA-2qpqA:
undetectable		 4klaA-2qpqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Mycolicibacterium
vanbaalenii) 		PF00440
(TetR_N) 		5 MET A  93
LEU A 154
LEU A 129
ILE A 176
VAL A 142
 None
 1.47A 4klaA-2qwtA:
undetectable		 4klaA-2qwtA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v70 SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 589
LEU A 613
LEU A 637
ILE A 587
VAL A 632
 None
 1.33A 4klaA-2v70A:
undetectable		 4klaA-2v70A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU B 326
LEU B 350
LEU B 371
ILE B 305
 None
 0.87A 4klaA-2v9tB:
undetectable		 4klaA-2v9tB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU A 803
LEU A 827
LEU A 848
ILE A 782
 None
 0.89A 4klaA-2wfhA:
undetectable		 4klaA-2wfhA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 LEU B 185
LEU B 188
LEU B 192
VAL B 242
 None
 0.85A 4klaA-2xdqB:
3.9		 4klaA-2xdqB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 MET A 387
LEU A 361
LEU A 364
LEU A 247
ILE A 114
 None
 1.41A 4klaA-2xkrA:
undetectable		 4klaA-2xkrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xot AMPHOTERIN-INDUCED
PROTEIN 1

(Mus musculus) 		PF07679
(I-set)
PF13855
(LRR_8) 		4 LEU A  93
LEU A 117
LEU A 139
VAL A 109
 None
 0.86A 4klaA-2xotA:
undetectable		 4klaA-2xotA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		5 LEU A 117
LEU A 159
ILE A  59
HIS A  64
VAL A 138
 None
 1.37A 4klaA-2xsgA:
undetectable		 4klaA-2xsgA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		4 LEU A 280
LEU A 284
LEU A 296
ILE A 321
 None
 0.85A 4klaA-2y35A:
undetectable		 4klaA-2y35A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		5 LEU A 305
LEU A 306
LEU A 314
ILE A 332
VAL A 376
 None
 1.31A 4klaA-2yeqA:
undetectable		 4klaA-2yeqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn GLYCOSYLTRANSFERASE

(Saccharopolyspora
erythraea) 		PF06722
(DUF1205) 		4 LEU A 201
LEU A 205
LEU A 209
HIS A 168
 None
 0.84A 4klaA-2yjnA:
undetectable		 4klaA-2yjnA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A

(Escherichia
coli) 		PF03737
(RraA-like) 		5 LEU A  51
LEU A  48
LEU A  73
ILE A  37
VAL A 131
 None
 1.45A 4klaA-2yjvA:
undetectable		 4klaA-2yjvA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		4 LEU A 250
LEU A 253
LEU A 257
ILE A 236
 None
 0.88A 4klaA-2yy5A:
undetectable		 4klaA-2yy5A:
22.66