SIMILAR PATTERNS OF AMINO ACIDS FOR 4KKY_X_CAMX503_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.14A 4kkyX-1d6hA:
undetectable		 4kkyX-1d6hA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij5 PLASMODIAL SPECIFIC
LAV1-2 PROTEIN

(Physarum
polycephalum) 		PF13202
(EF-hand_5) 		4 PHE A 344
LEU A 311
VAL A 310
VAL A 286
 None
 1.09A 4kkyX-1ij5A:
0.0		 4kkyX-1ij5A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554) 		PF12708
(Pectate_lyase_3) 		4 PHE A  94
VAL A 111
VAL A  52
ASP A  65
 None
None
None
CA  A   7 (-2.2A)
 1.15A 4kkyX-1ktwA:
0.0		 4kkyX-1ktwA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfp HYPOTHETICAL PROTEIN
AQ_1575

(Aquifex
aeolicus) 		PF01709
(Transcrip_reg) 		4 PHE A 117
LEU A 222
VAL A 234
VAL A 130
 None
 0.93A 4kkyX-1lfpA:
0.0		 4kkyX-1lfpA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7h YKOF

(Bacillus
subtilis) 		PF07615
(Ykof) 		4 PHE A  59
LEU A 187
VAL A 185
VAL A 170
 None
 1.16A 4kkyX-1s7hA:
undetectable		 4kkyX-1s7hA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.09A 4kkyX-1wytA:
0.0		 4kkyX-1wytA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		4 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.94A 4kkyX-1xf1A:
0.0		 4kkyX-1xf1A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys9 PROTEIN SPY1043

(Streptococcus
pyogenes) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 PHE A  27
LEU A 246
VAL A 225
VAL A 202
 None
 1.16A 4kkyX-1ys9A:
0.0		 4kkyX-1ys9A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		4 TYR A  93
LEU A 150
VAL A 138
VAL A  81
 SAZ  A 709 (-4.9A)
None
None
None
 0.98A 4kkyX-1yyrA:
0.0		 4kkyX-1yyrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1e STILBENE SYNTHASE

(Arachis
hypogaea) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.17A 4kkyX-1z1eA:
undetectable		 4kkyX-1z1eA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aco OUTER MEMBRANE
LIPOPROTEIN BLC

(Escherichia
coli) 		PF08212
(Lipocalin_2) 		4 TYR A  39
LEU A 141
VAL A 130
VAL A 106
 None
 1.08A 4kkyX-2acoA:
undetectable		 4kkyX-2acoA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajh LEUCYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF13603
(tRNA-synt_1_2) 		4 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.12A 4kkyX-2ajhA:
undetectable		 4kkyX-2ajhA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.97A 4kkyX-2awaA:
undetectable		 4kkyX-2awaA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 PHE A 205
TYR A 181
LEU A  35
VAL A  50
 None
 1.16A 4kkyX-2bg9A:
undetectable		 4kkyX-2bg9A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9i GREEN FLUORESCENT
PROTEIN ASFP499

(Anemonia
sulcata) 		PF01353
(GFP) 		4 PHE A  80
TYR A 178
VAL A 147
VAL A 214
 None
 1.01A 4kkyX-2c9iA:
undetectable		 4kkyX-2c9iA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct8 METHIONYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.08A 4kkyX-2ct8A:
undetectable		 4kkyX-2ct8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9f FK506-BINDING
PROTEIN 8 VARIANT

(Homo sapiens) 		PF00254
(FKBP_C) 		4 LEU A 118
VAL A 116
VAL A  69
ASP A  74
 None
 1.11A 4kkyX-2d9fA:
undetectable		 4kkyX-2d9fA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzr APOLIPOPROTEIN D

(Homo sapiens) 		PF08212
(Lipocalin_2) 		4 TYR A  22
LEU A 129
VAL A 111
VAL A  87
 None
 1.14A 4kkyX-2hzrA:
undetectable		 4kkyX-2hzrA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		4 PHE A 254
LEU A 194
VAL A 226
ASP A 198
 None
 1.02A 4kkyX-2i62A:
undetectable		 4kkyX-2i62A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Methanothermobacter
thermautotrophicus) 		PF01641
(SelR) 		4 PHE A  90
LEU A 123
VAL A 114
VAL A  94
 None
 0.93A 4kkyX-2k8dA:
undetectable		 4kkyX-2k8dA:
14.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		6 PHE A  87
TYR A  96
LEU A 244
VAL A 247
VAL A 295
ASP A 297
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
 0.29A 4kkyX-2m56A:
67.1		 4kkyX-2m56A:
98.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 PHE A  87
TYR A  96
LEU A 244
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
None
 0.70A 4kkyX-2m56A:
67.1		 4kkyX-2m56A:
98.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n67 HEMOLYSIN II

(Bacillus cereus) 		no annotation 4 PHE B  66
TYR B  64
LEU B  36
VAL B  16
 None
 1.09A 4kkyX-2n67B:
undetectable		 4kkyX-2n67B:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ott T-CELL SURFACE
GLYCOPROTEIN CD5

(Homo sapiens) 		PF00530
(SRCR) 		4 LEU X  82
VAL X  26
VAL X  98
ASP X  37
 None
 1.17A 4kkyX-2ottX:
undetectable		 4kkyX-2ottX:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy4 SINGLE DOMAIN
HAEMOGLOBIN

(Campylobacter
jejuni) 		PF00042
(Globin) 		4 PHE A  42
TYR A  28
LEU A  56
VAL A  89
 HEM  A 150 ( 3.5A)
CYN  A 151 (-4.7A)
CYN  A 151 (-4.1A)
HEM  A 150 (-3.8A)
 1.08A 4kkyX-2wy4A:
undetectable		 4kkyX-2wy4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 LEU A  68
VAL A  65
VAL A  91
ASP A 404
 None
 1.16A 4kkyX-2xvgA:
undetectable		 4kkyX-2xvgA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		4 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.12A 4kkyX-2yh2A:
undetectable		 4kkyX-2yh2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yps SORTING NEXIN-3

(Homo sapiens) 		PF00787
(PX) 		4 PHE A 144
LEU A 122
VAL A  33
ASP A  73
 None
 1.12A 4kkyX-2ypsA:
undetectable		 4kkyX-2ypsA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhp BLEOMYCIN RESISTANCE
PROTEIN

(Streptoalloteichus
hindustanus) 		no annotation 4 PHE A  29
LEU A 108
VAL A 116
VAL A  68
 None
 1.09A 4kkyX-2zhpA:
undetectable		 4kkyX-2zhpA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 366
LEU A 303
VAL A 306
VAL A 362
 None
 1.17A 4kkyX-3a5rA:
undetectable		 4kkyX-3a5rA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Methylobacillus
flagellatus) 		PF03069
(FmdA_AmdA) 		4 TYR A 227
LEU A 279
VAL A 278
VAL A 223
 None
 0.89A 4kkyX-3b9tA:
undetectable		 4kkyX-3b9tA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9h ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		4 PHE A 146
LEU A 162
VAL A 169
VAL A 223
 None
 1.16A 4kkyX-3c9hA:
undetectable		 4kkyX-3c9hA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 LEU A 365
VAL A 151
VAL A 125
ASP A 127
 None
 1.00A 4kkyX-3g05A:
undetectable		 4kkyX-3g05A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		4 PHE A 302
LEU A  32
VAL A 344
VAL A 389
 None
 1.13A 4kkyX-3g8mA:
undetectable		 4kkyX-3g8mA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		4 LEU A 188
VAL A 216
VAL A 129
ASP A 126
 None
 1.16A 4kkyX-3hamA:
undetectable		 4kkyX-3hamA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp7 HEMOLYSIN, PUTATIVE

(Streptococcus
thermophilus) 		PF01479
(S4)
PF01728
(FtsJ) 		4 PHE A  77
LEU A 181
VAL A 261
ASP A 227
 None
 1.17A 4kkyX-3hp7A:
undetectable		 4kkyX-3hp7A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		4 PHE A 105
TYR A 447
LEU A 425
VAL A 512
 None
 1.13A 4kkyX-3j1cA:
undetectable		 4kkyX-3j1cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl2 PUTATIVE
ISOCHORISMATASE

(Streptomyces
avermitilis) 		PF00857
(Isochorismatase) 		4 PHE A 154
LEU A 173
VAL A 196
VAL A 168
 None
 1.15A 4kkyX-3kl2A:
undetectable		 4kkyX-3kl2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ko7 D-TYROSYL-TRNA(TYR)
DEACYLASE

(Plasmodium
falciparum) 		PF02580
(Tyr_Deacylase) 		4 LEU A  79
VAL A  76
VAL A 151
ASP A 148
 None
 0.94A 4kkyX-3ko7A:
undetectable		 4kkyX-3ko7A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbt OUTER MEMBRANE
LIPOPROTEIN BLC

(Escherichia
coli) 		PF08212
(Lipocalin_2) 		4 TYR A  21
LEU A 123
VAL A 112
VAL A  88
 None
 1.06A 4kkyX-3mbtA:
undetectable		 4kkyX-3mbtA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myu HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
genitalium) 		PF06646
(Mycoplasma_p37) 		4 PHE A  36
LEU A  59
VAL A 312
ASP A  90
 None
 1.13A 4kkyX-3myuA:
undetectable		 4kkyX-3myuA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 PHE A1532
LEU A1511
VAL A1498
VAL A1489
 None
None
None
GOL  A   1 ( 4.7A)
 0.99A 4kkyX-3pvlA:
undetectable		 4kkyX-3pvlA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Streptococcus
mutans) 		PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LEU A  95
VAL A  92
VAL A  82
ASP A  50
 None
 0.99A 4kkyX-3sqzA:
undetectable		 4kkyX-3sqzA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		4 PHE A 586
LEU A 590
VAL A 444
ASP A 441
 None
 0.89A 4kkyX-3t6gA:
undetectable		 4kkyX-3t6gA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9

(Veillonella
parvula) 		PF01075
(Glyco_transf_9) 		4 LEU A 249
VAL A  49
VAL A  61
ASP A  43
 None
 0.97A 4kkyX-3tovA:
undetectable		 4kkyX-3tovA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 PHE A 960
LEU A 897
VAL A 900
VAL A 956
 None
 1.17A 4kkyX-3tsyA:
undetectable		 4kkyX-3tsyA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		4 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.03A 4kkyX-3ubcA:
undetectable		 4kkyX-3ubcA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umf ADENYLATE KINASE

(Schistosoma
mansoni) 		PF00406
(ADK) 		4 PHE A  13
TYR A  96
LEU A  74
VAL A 110
 None
 0.87A 4kkyX-3umfA:
undetectable		 4kkyX-3umfA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		4 PHE A 325
LEU A 311
VAL A 333
VAL A 293
 None
 1.17A 4kkyX-3wfzA:
undetectable		 4kkyX-3wfzA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 PHE A 205
TYR A 181
LEU A  35
VAL A  50
 None
 1.16A 4kkyX-4booA:
undetectable		 4kkyX-4booA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bru ATP-DEPENDENT RNA
HELICASE DHH1

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.07A 4kkyX-4bruA:
undetectable		 4kkyX-4bruA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 TYR A  98
LEU A 252
VAL A 303
ASP A 305
 None
HEM  A1418 (-4.0A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
 0.64A 4kkyX-4c9mA:
58.1		 4kkyX-4c9mA:
45.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 112
LEU A 281
VAL A 280
VAL A 119
 None
 1.17A 4kkyX-4euuA:
undetectable		 4kkyX-4euuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.14A 4kkyX-4g1pA:
undetectable		 4kkyX-4g1pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Mycolicibacterium
thermoresistibile) 		PF16113
(ECH_2) 		4 PHE A 172
LEU A 153
VAL A 118
VAL A 129
 None
 1.05A 4kkyX-4hdtA:
undetectable		 4kkyX-4hdtA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 PHE A3640
TYR A3638
LEU A3551
ASP A3126
 None
 1.15A 4kkyX-4kc5A:
undetectable		 4kkyX-4kc5A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE

(Sorghum bicolor) 		PF02458
(Transferase) 		4 PHE A 173
LEU A 144
VAL A 100
VAL A 164
 None
 1.17A 4kkyX-4ke4A:
undetectable		 4kkyX-4ke4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvs ALDEHYDE
DECARBONYLASE

(Prochlorococcus
marinus) 		PF11266
(Ald_deCOase) 		4 TYR A  30
LEU A  87
VAL A  89
VAL A  41
 None
None
None
6NA  A 301 ( 4.2A)
 1.16A 4kkyX-4kvsA:
undetectable		 4kkyX-4kvsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		4 TYR A 314
LEU A 342
VAL A 350
VAL A 355
 None
 1.16A 4kkyX-4n0rA:
undetectable		 4kkyX-4n0rA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofq PUTATIVE CELL
SURFACE PROTEIN

(Streptococcus
pyogenes) 		PF16364
(Antigen_C) 		4 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.13A 4kkyX-4ofqA:
undetectable		 4kkyX-4ofqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE

(Mycobacterium
tuberculosis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 PHE A 153
LEU A  21
VAL A  17
VAL A 164
 None
 1.12A 4kkyX-4ol9A:
undetectable		 4kkyX-4ol9A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pav GLYOXALASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF00903
(Glyoxalase) 		4 PHE A 120
LEU A  50
VAL A  48
VAL A  71
 None
 1.13A 4kkyX-4pavA:
undetectable		 4kkyX-4pavA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.09A 4kkyX-4rhhA:
undetectable		 4kkyX-4rhhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4std SCYTALONE
DEHYDRATASE

(Magnaporthe
grisea) 		PF02982
(Scytalone_dh) 		4 PHE A  53
TYR A  50
VAL A  75
VAL A 108
 None
BFS  A 173 (-4.3A)
BFS  A 173 (-4.5A)
BFS  A 173 ( 4.4A)
 1.06A 4kkyX-4stdA:
undetectable		 4kkyX-4stdA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.15A 4kkyX-4wumA:
undetectable		 4kkyX-4wumA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 PHE A 128
TYR A 225
LEU A 169
VAL A 172
 None
 1.06A 4kkyX-4wy8A:
undetectable		 4kkyX-4wy8A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxw PROTOCADHERIN-15

(Mus musculus) 		no annotation 5 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.31A 4kkyX-4xxwB:
undetectable		 4kkyX-4xxwB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		4 PHE A 163
TYR A 202
VAL A 151
VAL A 117
 None
 0.91A 4kkyX-4y96A:
undetectable		 4kkyX-4y96A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjy CHALCONE SYNTHASE 1

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 376
LEU A 313
VAL A 316
VAL A 372
 None
 1.13A 4kkyX-4yjyA:
undetectable		 4kkyX-4yjyA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		4 PHE A 125
TYR A 220
LEU A 164
VAL A 167
 None
 1.08A 4kkyX-4ypvA:
undetectable		 4kkyX-4ypvA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1p CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		4 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.16A 4kkyX-4z1pA:
undetectable		 4kkyX-4z1pA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z23 CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		4 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.12A 4kkyX-4z23A:
undetectable		 4kkyX-4z23A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.06A 4kkyX-5a2rA:
undetectable		 4kkyX-5a2rA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF01008
(IF-2B)
PF01008
(IF-2B) 		4 TYR G 331
LEU C 351
VAL G 324
VAL G 270
 None
 1.14A 4kkyX-5b04G:
undetectable		 4kkyX-5b04G:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cay ENVELOPE
GLYCOPROTEIN GP120
CORE FROM ST STRAIN
OF HIV-2

(Human
immunodeficiency
virus 2) 		PF00516
(GP120) 		4 PHE G 482
LEU G 301
VAL G 357
VAL G 412
 None
 1.06A 4kkyX-5cayG:
undetectable		 4kkyX-5cayG:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj3 ZBM BINDING PROTEIN

(Streptomyces
flavoviridis) 		no annotation 4 PHE A  29
LEU A 108
VAL A 116
VAL A  68
 None
 1.12A 4kkyX-5cj3A:
undetectable		 4kkyX-5cj3A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7z LACTOYLGLUTATHIONE
LYASE

(Zea mays) 		PF00903
(Glyoxalase) 		4 PHE A 143
LEU A  66
VAL A  77
ASP A 137
 None
 1.08A 4kkyX-5d7zA:
undetectable		 4kkyX-5d7zA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5v PRP38

(Chaetomium
thermophilum) 		PF03371
(PRP38) 		4 TYR A 105
LEU A 119
VAL A  65
VAL A  56
 None
 0.97A 4kkyX-5f5vA:
undetectable		 4kkyX-5f5vA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 TYR A 627
LEU A 574
VAL A 500
ASP A 530
 None
 1.12A 4kkyX-5gxdA:
undetectable		 4kkyX-5gxdA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		4 PHE A 719
LEU A 762
VAL A 765
VAL A 744
 None
 1.16A 4kkyX-5irmA:
undetectable		 4kkyX-5irmA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		4 LEU A 532
VAL A 638
VAL A 699
ASP A 652
 None
 1.16A 4kkyX-5jjhA:
undetectable		 4kkyX-5jjhA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		4 TYR A  17
LEU A  74
VAL A  76
VAL A  28
 None
None
None
OCD  A 500 ( 4.6A)
 1.17A 4kkyX-5k52A:
undetectable		 4kkyX-5k52A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k53 ALDEHYDE
DEFORMYLATING
OXYGENASE

(Oscillatoria
sp.) 		PF11266
(Ald_deCOase) 		4 TYR A  17
LEU A  74
VAL A  76
VAL A  28
 None
None
None
STE  A 502 ( 4.8A)
 1.03A 4kkyX-5k53A:
undetectable		 4kkyX-5k53A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kpe DE NOVO BETA SHEET
DESIGN PROTEIN OR664

(synthetic
construct) 		no annotation 4 PHE A  94
LEU A  31
VAL A  39
VAL A 106
 None
 1.04A 4kkyX-5kpeA:
undetectable		 4kkyX-5kpeA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd MON1
CCZ1

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF03164
(Mon1)
PF08217
(DUF1712) 		4 PHE B 114
LEU A 226
VAL A 287
VAL A 274
 None
 0.99A 4kkyX-5lddB:
undetectable		 4kkyX-5lddB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmx DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT
RPAC1,DNA-DIRECTED
RNA POLYMERASES I
AND III SUBUNIT
RPAC1

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 PHE C 251
LEU C 280
VAL C 289
ASP C 273
 PHE  C 251 ( 1.3A)
LEU  C 280 ( 0.5A)
VAL  C 289 ( 0.5A)
ASP  C 273 ( 0.6A)
 0.96A 4kkyX-5lmxC:
undetectable		 4kkyX-5lmxC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt9 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTB

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		4 PHE A  99
LEU A 117
VAL A 153
ASP A 173
 ARG  A 301 (-3.6A)
ARG  A 301 (-4.7A)
None
ARG  A 301 (-3.1A)
 1.17A 4kkyX-5lt9A:
undetectable		 4kkyX-5lt9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		4 LEU J 358
VAL J 365
VAL J 449
ASP J 405
 None
 1.01A 4kkyX-5nilJ:
undetectable		 4kkyX-5nilJ:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy7 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		4 PHE B 176
LEU B 187
VAL B 183
VAL B 318
 None
 1.06A 4kkyX-5sy7B:
undetectable		 4kkyX-5sy7B:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpj DENOVO NTF2

(synthetic
construct) 		PF12680
(SnoaL_2) 		4 PHE A  89
LEU A  17
VAL A  62
VAL A  76
 None
 1.13A 4kkyX-5tpjA:
undetectable		 4kkyX-5tpjA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE

(Malus domestica) 		no annotation 4 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.11A 4kkyX-5uc5A:
undetectable		 4kkyX-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE

(Hypericum
androsaemum) 		no annotation 4 TYR A 304
LEU A 321
VAL A 317
VAL A 383
 None
 1.03A 4kkyX-5ucoA:
undetectable		 4kkyX-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1m U6 SNRNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF09749
(HVSL) 		4 PHE A 151
LEU A 123
VAL A  87
VAL A 175
 None
 1.15A 4kkyX-5v1mA:
undetectable		 4kkyX-5v1mA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		4 PHE A 301
LEU A  31
VAL A 343
VAL A 388
 None
 1.17A 4kkyX-5vmbA:
undetectable		 4kkyX-5vmbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrr PSEUDOKINASE FAM20A

(Homo sapiens) 		PF06702
(Fam20C) 		4 PHE A  96
TYR A 101
LEU A 466
VAL A 476
 None
 1.11A 4kkyX-5wrrA:
undetectable		 4kkyX-5wrrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtn REPLICATION
INITIATION AND
MEMBRANE ATTACHMENT
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 4 PHE A 211
LEU A 266
VAL A 229
VAL A 220
 None
 1.14A 4kkyX-5wtnA:
undetectable		 4kkyX-5wtnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2g CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Campylobacter
jejuni) 		no annotation 4 PHE A   7
LEU A 467
VAL A 473
VAL A 679
 None
 1.17A 4kkyX-5x2gA:
undetectable		 4kkyX-5x2gA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN

(Homo sapiens) 		no annotation 4 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.12A 4kkyX-5yewB:
undetectable		 4kkyX-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co0 STYRYLPYRONE
SYNTHASE 1

(Piper
methysticum) 		no annotation 4 PHE A 374
LEU A 311
VAL A 314
VAL A 370
 None
 1.12A 4kkyX-6co0A:
undetectable		 4kkyX-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 4 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.08A 4kkyX-6fmlD:
undetectable		 4kkyX-6fmlD:
undetectable