SIMILAR PATTERNS OF AMINO ACIDS FOR 4KIC_B_SAMB401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		3 ARG A 290
ASP A 276
ASP A 269
 None
 0.85A 4kicB-1cbgA:
0.0		 4kicB-1cbgA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		3 ARG M 106
ASP M 163
ASP M 157
 None
 0.73A 4kicB-1dwaM:
1.2		 4kicB-1dwaM:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		3 ARG A 202
ASP A 224
ASP A 360
 None
 0.67A 4kicB-1fn9A:
undetectable		 4kicB-1fn9A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 ARG A 232
ASP A 674
ASP A 669
 None
 0.89A 4kicB-1g8xA:
0.1		 4kicB-1g8xA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		3 ARG A 120
ASP A  41
ASP A  77
 None
 0.90A 4kicB-1h1yA:
1.0		 4kicB-1h1yA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		3 ARG A 104
ASP A  63
ASP A 114
 None
 0.87A 4kicB-1hcuA:
undetectable		 4kicB-1hcuA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima) 		PF02614
(UxaC) 		3 ARG A 191
ASP A 204
ASP A 209
 None
 0.73A 4kicB-1j5sA:
0.8		 4kicB-1j5sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1c TRANSCRIPTION
ANTITERMINATOR LICT

(Bacillus
subtilis) 		PF03123
(CAT_RBD) 		3 ARG A  27
ASP A  40
ASP A  37
 A  C  27 ( 2.9A)
None
None
 0.91A 4kicB-1l1cA:
undetectable		 4kicB-1l1cA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		3 ARG A 251
ASP A 243
ASP A  66
 None
 0.91A 4kicB-1piiA:
0.2		 4kicB-1piiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn9 GLUTATHIONE
S-TRANSFERASE 1-6

(Anopheles
gambiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ARG A 185
ASP A 151
ASP A  79
 None
 0.55A 4kicB-1pn9A:
0.2		 4kicB-1pn9A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		3 ARG A 171
ASP A 263
ASP A 224
 None
 0.79A 4kicB-1u8vA:
undetectable		 4kicB-1u8vA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		3 ARG A 219
ASP A 224
ASP A 231
 None
 0.87A 4kicB-1up2A:
undetectable		 4kicB-1up2A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I

(Thermoproteus
tenax) 		PF01791
(DeoC) 		3 ARG A 237
ASP A  33
ASP A  24
 None
None
FBP  A 270 (-2.8A)
 0.78A 4kicB-1w8sA:
undetectable		 4kicB-1w8sA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 ARG A 920
ASP A 556
ASP A 594
 None
 0.70A 4kicB-1yq2A:
undetectable		 4kicB-1yq2A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6y EMP47P (FORM1)

(Saccharomyces
cerevisiae) 		PF03388
(Lectin_leg-like) 		3 ARG A 192
ASP A 172
ASP A 230
 None
 0.87A 4kicB-2a6yA:
undetectable		 4kicB-2a6yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON

(Salmonella
enterica) 		PF01569
(PAP2) 		3 ARG A 130
ASP A  53
ASP A  47
 WO4  A 501 (-2.7A)
None
None
 0.69A 4kicB-2akcA:
undetectable		 4kicB-2akcA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 ARG A 112
ASP A 124
ASP A 284
 None
 0.87A 4kicB-2csdA:
undetectable		 4kicB-2csdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmj POLY (ADP-RIBOSE)
POLYMERASE FAMILY,
MEMBER 1

(Homo sapiens) 		PF00645
(zf-PARP) 		3 ARG A  41
ASP A  79
ASP A  13
 None
 0.83A 4kicB-2dmjA:
undetectable		 4kicB-2dmjA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		3 ARG A  61
ASP A  78
ASP A 120
 None
 0.80A 4kicB-2dulA:
12.2		 4kicB-2dulA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		3 ARG A 102
ASP A 398
ASP A  74
 None
 0.88A 4kicB-2e0wA:
undetectable		 4kicB-2e0wA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli;
Escherichia
coli) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		3 ARG A 102
ASP B 398
ASP A  74
 None
 0.88A 4kicB-2e0xA:
undetectable		 4kicB-2e0xA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfs CONSERVED
HYPOTHETICAL
REGULATORY PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 3 ARG A  51
ASP A  95
ASP A  21
 None
 0.88A 4kicB-2kfsA:
undetectable		 4kicB-2kfsA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2noq 60S RIBOSOMAL
PROTEIN L11-B

(Saccharomyces
cerevisiae) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		3 ARG H  91
ASP H 157
ASP H  10
 None
 0.83A 4kicB-2noqH:
undetectable		 4kicB-2noqH:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrx UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		3 ARG A 478
ASP A 485
ASP A 429
 None
 0.74A 4kicB-2nrxA:
undetectable		 4kicB-2nrxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A

(Methanosarcina
mazei) 		PF04406
(TP6A_N) 		3 ARG A 261
ASP A 309
ASP A 303
 None
 0.89A 4kicB-2q2eA:
undetectable		 4kicB-2q2eA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe8 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF03022
(MRJP) 		3 ARG A 148
ASP A 127
ASP A 202
 None
 0.89A 4kicB-2qe8A:
undetectable		 4kicB-2qe8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii) 		PF01823
(MACPF) 		3 ARG A 354
ASP A 405
ASP A 409
 None
 0.65A 4kicB-2qp2A:
undetectable		 4kicB-2qp2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		3 ARG A 176
ASP A 144
ASP A 153
 None
None
MPD  A 701 ( 4.5A)
 0.64A 4kicB-2vmxA:
2.6		 4kicB-2vmxA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		3 ARG A  53
ASP A 249
ASP A 236
 BTB  A 620 (-3.7A)
None
CA  A 650 (-2.2A)
 0.88A 4kicB-2vn7A:
undetectable		 4kicB-2vn7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		3 ARG A 616
ASP A 750
ASP A 720
 None
 0.58A 4kicB-2vuwA:
undetectable		 4kicB-2vuwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 ARG A  59
ASP A 843
ASP A 849
 None
 0.90A 4kicB-2vz9A:
undetectable		 4kicB-2vz9A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		3 ARG A 394
ASP A 244
ASP A 237
 None
 0.89A 4kicB-2x9pA:
undetectable		 4kicB-2x9pA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 ARG A 456
ASP A 461
ASP A 468
 None
 0.63A 4kicB-2yfnA:
undetectable		 4kicB-2yfnA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		3 ARG A 354
ASP A 363
ASP A 184
 None
 0.89A 4kicB-3a3cA:
undetectable		 4kicB-3a3cA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE

(Methanococcus
maripaludis) 		PF08241
(Methyltransf_11) 		3 ARG A 117
ASP A  72
ASP A 100
 SAM  A 220 (-4.0A)
SAM  A 220 (-2.9A)
SAM  A 220 (-3.2A)
 0.50A 4kicB-3dlcA:
15.2		 4kicB-3dlcA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv8 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

([Eubacterium]
rectale) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		3 ARG A  70
ASP A  73
ASP A 101
 None
 0.86A 4kicB-3dv8A:
2.9		 4kicB-3dv8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feo MBT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02820
(MBT) 		3 ARG A 172
ASP A 300
ASP A 265
 None
 0.87A 4kicB-3feoA:
undetectable		 4kicB-3feoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3o VACUOLAR TRANSPORTER
CHAPERONE 2

(Saccharomyces
cerevisiae) 		PF09359
(VTC) 		3 ARG A 401
ASP A 431
ASP A 534
 None
 0.84A 4kicB-3g3oA:
undetectable		 4kicB-3g3oA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gov MASP-1

(Homo sapiens) 		PF00089
(Trypsin) 		3 ARG B 504
ASP B 545
ASP B 552
 None
 0.84A 4kicB-3govB:
undetectable		 4kicB-3govB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3e UNCHARACTERIZED
PROTEIN TM1679

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		3 ARG A  77
ASP A 179
ASP A 174
 None
 0.63A 4kicB-3h3eA:
undetectable		 4kicB-3h3eA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6z POLYCOMB PROTEIN
SFMBT

(Drosophila
melanogaster) 		PF02820
(MBT) 		3 ARG A 922
ASP A 725
ASP A 723
 None
 0.83A 4kicB-3h6zA:
undetectable		 4kicB-3h6zA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ARG A  59
ASP A 843
ASP A 849
 None
 0.82A 4kicB-3hhdA:
undetectable		 4kicB-3hhdA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj6 FRUCTOKINASE

(Halothermothrix
orenii) 		PF00294
(PfkB) 		3 ARG A 161
ASP A 129
ASP A 103
 None
 0.82A 4kicB-3hj6A:
undetectable		 4kicB-3hj6A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hk4 MLR7391 PROTEIN

(Mesorhizobium
loti) 		PF12680
(SnoaL_2) 		3 ARG A  51
ASP A  18
ASP A   9
 None
 0.86A 4kicB-3hk4A:
undetectable		 4kicB-3hk4A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE

(Oceanobacillus
iheyensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 236
ASP A 240
ASP A 214
 None
 0.88A 4kicB-3hpfA:
undetectable		 4kicB-3hpfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE

(Clostridium
acetobutylicum) 		PF00730
(HhH-GPD)
PF07934
(OGG_N) 		3 ARG A 112
ASP A   2
ASP A   4
 None
 0.74A 4kicB-3i0wA:
undetectable		 4kicB-3i0wA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ief TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Bartonella
henselae) 		PF01746
(tRNA_m1G_MT) 		3 ARG A 124
ASP A 117
ASP A  53
 None
 0.88A 4kicB-3iefA:
undetectable		 4kicB-3iefA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec) 		3 ARG A 293
ASP A 228
ASP A 231
 None
 0.81A 4kicB-3javA:
undetectable		 4kicB-3javA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		3 ARG A  93
ASP A  56
ASP A 151
 None
 0.91A 4kicB-3k5wA:
5.5		 4kicB-3k5wA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kng SNOAB

(Streptomyces
nogalater) 		PF03992
(ABM) 		3 ARG A 103
ASP A  12
ASP A  71
 None
 0.58A 4kicB-3kngA:
undetectable		 4kicB-3kngA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llv EXOPOLYPHOSPHATASE-R
ELATED PROTEIN

(Archaeoglobus
fulgidus) 		PF02254
(TrkA_N) 		3 ARG A 102
ASP A  36
ASP A  56
 PO4  A 142 (-2.7A)
None
None
 0.79A 4kicB-3llvA:
undetectable		 4kicB-3llvA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR

(Legionella
pneumophila) 		PF14860
(DrrA_P4M) 		3 ARG A 453
ASP A 445
ASP A 387
 None
 0.85A 4kicB-3n6oA:
undetectable		 4kicB-3n6oA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7z ACETYLTRANSFERASE,
GNAT FAMILY

(Bacillus
anthracis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 ARG A 271
ASP A 145
ASP A 252
 None
 0.84A 4kicB-3n7zA:
undetectable		 4kicB-3n7zA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		3 ARG A 223
ASP A 174
ASP A 117
 None
ANP  A 430 (-2.8A)
ANP  A 430 (-3.3A)
 0.73A 4kicB-3nieA:
undetectable		 4kicB-3nieA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohe HISTIDINE TRIAD
(HIT) PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF01230
(HIT) 		3 ARG A  96
ASP A  28
ASP A  11
 None
GOL  A 139 (-3.6A)
GOL  A 140 (-3.7A)
 0.75A 4kicB-3oheA:
undetectable		 4kicB-3oheA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oos ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		3 ARG A  84
ASP A  79
ASP A  63
 None
 0.87A 4kicB-3oosA:
undetectable		 4kicB-3oosA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ops MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Paenibacillus
sp. Y412MC10) 		PF13378
(MR_MLE_C) 		3 ARG A  28
ASP A 139
ASP A 144
 None
 0.80A 4kicB-3opsA:
undetectable		 4kicB-3opsA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pge SUMO-MODIFIED
PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF02747
(PCNA_C)
PF11976
(Rad60-SLD) 		3 ARG A 164
ASP A  68
ASP A  82
 None
 0.76A 4kicB-3pgeA:
undetectable		 4kicB-3pgeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		3 ARG A 910
ASP A 501
ASP A 450
 None
 0.91A 4kicB-3pihA:
undetectable		 4kicB-3pihA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		3 ARG A 532
ASP A 669
ASP A 678
 None
 0.51A 4kicB-3poyA:
undetectable		 4kicB-3poyA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2k OXIDOREDUCTASE

(Bordetella
pertussis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 ARG A 114
ASP A 120
ASP A 321
 None
 0.91A 4kicB-3q2kA:
undetectable		 4kicB-3q2kA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Vibrio cholerae) 		PF02540
(NAD_synthase) 		3 ARG A  24
ASP A  49
ASP A 182
 None
CA  A 279 (-4.9A)
None
 0.87A 4kicB-3q4gA:
undetectable		 4kicB-3q4gA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 ARG A 452
ASP A  93
ASP A  97
 None
 0.71A 4kicB-3redA:
undetectable		 4kicB-3redA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		3 ARG X1712
ASP X1998
ASP X1567
 None
 0.86A 4kicB-3su8X:
undetectable		 4kicB-3su8X:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 ARG A  80
ASP A  41
ASP A  18
 None
 0.85A 4kicB-3uc3A:
undetectable		 4kicB-3uc3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1

(Homo sapiens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A  19
ASP A  35
ASP A  30
 EDO  A1447 (-4.0A)
None
None
 0.67A 4kicB-4a35A:
2.3		 4kicB-4a35A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		3 ARG A  86
ASP A  91
ASP A 127
 None
 0.74A 4kicB-4bx9A:
3.1		 4kicB-4bx9A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxk ARYLSULFATASE

(Pseudomonas
aeruginosa) 		PF00884
(Sulfatase) 		3 ARG A 436
ASP A 409
ASP A 416
 None
 0.89A 4kicB-4cxkA:
undetectable		 4kicB-4cxkA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
knowlesi) 		PF08241
(Methyltransf_11) 		3 ARG A 125
ASP A  83
ASP A 108
 None
SAM  A 301 (-2.7A)
SAM  A 301 (-3.5A)
 0.86A 4kicB-4iv8A:
14.8		 4kicB-4iv8A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo sapiens) 		PF00328
(His_Phos_2) 		3 ARG A 219
ASP A 248
ASP A 254
 None
 0.88A 4kicB-4jocA:
undetectable		 4kicB-4jocA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpq UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF16011
(CBM9_2) 		3 ARG A 167
ASP A 117
ASP A 218
 None
None
CXS  A 301 ( 4.5A)
 0.87A 4kicB-4jpqA:
undetectable		 4kicB-4jpqA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m73 METHYLTRANSFERASE
MPPJ

(Streptomyces
hygroscopicus) 		PF13649
(Methyltransf_25) 		3 ARG A 172
ASP A 189
ASP A 217
 SAH  A 401 (-3.8A)
SAH  A 401 (-2.7A)
SAH  A 401 ( 3.7A)
 0.26A 4kicB-4m73A:
46.1		 4kicB-4m73A:
93.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		3 ARG A  63
ASP A  90
ASP A  97
 None
 0.83A 4kicB-4ohtA:
4.3		 4kicB-4ohtA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Deinococcus
radiodurans) 		PF02540
(NAD_synthase) 		3 ARG A  34
ASP A  59
ASP A 182
 None
SO4  A 301 (-4.2A)
None
 0.92A 4kicB-4q16A:
undetectable		 4kicB-4q16A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 3 ARG H 310
ASP H 427
ASP H 373
 None
 0.92A 4kicB-4qfkH:
undetectable		 4kicB-4qfkH:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		3 ARG A 148
ASP A 167
ASP A 110
 None
ANP  A 402 ( 2.6A)
ANP  A 402 (-3.4A)
 0.59A 4kicB-4qnyA:
undetectable		 4kicB-4qnyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 ARG A 330
ASP A 277
ASP A 256
 None
 0.85A 4kicB-4v2eA:
undetectable		 4kicB-4v2eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsh UROPORPHYRINOGEN
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF01208
(URO-D) 		3 ARG A 243
ASP A   7
ASP A  71
 SO4  A 405 (-4.3A)
None
None
 0.83A 4kicB-4wshA:
undetectable		 4kicB-4wshA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		3 ARG A 470
ASP A 578
ASP A 255
 None
 0.76A 4kicB-4zajA:
undetectable		 4kicB-4zajA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		3 ARG A1241
ASP A1171
ASP A1163
 None
 0.88A 4kicB-4zhjA:
undetectable		 4kicB-4zhjA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		3 ARG A 370
ASP A 333
ASP A 223
 None
 0.85A 4kicB-5ffjA:
10.3		 4kicB-5ffjA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 3 ARG A 634
ASP A 626
ASP A 622
 None
 0.75A 4kicB-5h2rA:
undetectable		 4kicB-5h2rA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		3 ARG A 999
ASP A1066
ASP A1061
 None
 0.73A 4kicB-5ikzA:
undetectable		 4kicB-5ikzA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		3 ARG A 265
ASP A 302
ASP A 269
 None
 0.92A 4kicB-5ivaA:
undetectable		 4kicB-5ivaA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxb WISTERIA FLORIBUNDA
AGGLUTININ

(Wisteria
floribunda) 		PF00139
(Lectin_legB) 		3 ARG A  40
ASP A 254
ASP A 190
 None
 0.78A 4kicB-5kxbA:
undetectable		 4kicB-5kxbA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 ARG A 106
ASP A 338
ASP A 366
 None
 0.80A 4kicB-5lkdA:
undetectable		 4kicB-5lkdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m58 C-METHYLTRANSFERASE
COUO

(Streptomyces
rishiriensis) 		PF13649
(Methyltransf_25) 		3 ARG A 116
ASP A  70
ASP A  96
 SAH  A 301 (-3.9A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.47A 4kicB-5m58A:
16.2		 4kicB-5m58A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE

(Streptomyces
niveus) 		PF13649
(Methyltransf_25) 		3 ARG A 116
ASP A  70
ASP A  96
 SAH  A 301 ( 3.9A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.52A 4kicB-5mgzA:
4.8		 4kicB-5mgzA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr6 XIAF PROTEIN

(Streptomyces
sp.) 		PF08028
(Acyl-CoA_dh_2) 		3 ARG A 324
ASP A 309
ASP A  67
 None
 0.51A 4kicB-5mr6A:
undetectable		 4kicB-5mr6A:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 3 ARG A 547
ASP A  34
ASP A  47
 None
 0.78A 4kicB-5necA:
undetectable		 4kicB-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		3 ARG A 401
ASP A 522
ASP A 516
 None
 0.67A 4kicB-5nvrA:
undetectable		 4kicB-5nvrA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 ARG D 345
ASP D 339
ASP D 404
 None
 0.90A 4kicB-5uheD:
undetectable		 4kicB-5uheD:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp0 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Aliivibrio
fischeri) 		PF02540
(NAD_synthase) 		3 ARG A  24
ASP A  49
ASP A 182
 None
 0.84A 4kicB-5wp0A:
undetectable		 4kicB-5wp0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		3 ARG A 145
ASP A 376
ASP A 304
 None
 0.89A 4kicB-5x7hA:
undetectable		 4kicB-5x7hA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 3 ARG A 247
ASP A 241
ASP A 259
 None
 0.87A 4kicB-5x8oA:
undetectable		 4kicB-5x8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivorans) 		no annotation 3 ARG A 334
ASP A  77
ASP A  73
 None
 0.57A 4kicB-5yapA:
undetectable		 4kicB-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC

(Zea mays) 		no annotation 3 ARG 2 219
ASP 2  85
ASP 2  89
 None
None
CLA  2 602 ( 3.4A)
 0.81A 4kicB-5zji2:
undetectable		 4kicB-5zji2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anr COLIBACTIN
SELF-PROTECTION
PROTEIN CLBS

(Escherichia
coli) 		no annotation 3 ARG A  90
ASP A  98
ASP A 101
 None
 0.85A 4kicB-6anrA:
undetectable		 4kicB-6anrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 3 ARG A1077
ASP A1054
ASP A1020
 None
 0.79A 4kicB-6d35A:
undetectable		 4kicB-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftx -

(-) 		no annotation 3 ARG W 804
ASP W 798
ASP W 790
 BEF  W1301 (-3.6A)
None
None
 0.80A 4kicB-6ftxW:
undetectable		 4kicB-6ftxW:
undetectable