SIMILAR PATTERNS OF AMINO ACIDS FOR 4KFB_A_T27A607_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axd GLUTATHIONE
S-TRANSFERASE I

(Zea mays) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.45A 4kfbA-1axdA:
0.0		 4kfbA-1axdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1doi 2FE-2S FERREDOXIN

(Haloarcula
marismortui) 		PF00111
(Fer2) 		5 PRO A  60
VAL A   3
TYR A 115
TYR A   5
PRO A 106
 K  A 204 ( 4.6A)
None
None
None
None
 1.29A 4kfbA-1doiA:
undetectable		 4kfbA-1doiA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kol FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 249
VAL A 255
VAL A 212
TYR A 190
PRO A 253
 None
 1.08A 4kfbA-1kolA:
0.0		 4kfbA-1kolA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmy SIMILAR TO
THYMIDYLATE KINASE
(DTMP KINASE)

(Homo sapiens) 		PF02223
(Thymidylate_kin) 		5 PRO A 127
LEU A 210
LYS A 118
VAL A 103
PRO A 120
 None
 1.33A 4kfbA-1nmyA:
undetectable		 4kfbA-1nmyA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpx CARBOXYPEPTIDASE Y
INHIBITOR

(Saccharomyces
cerevisiae) 		PF01161
(PBP) 		5 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.37A 4kfbA-1wpxB:
undetectable		 4kfbA-1wpxB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Vibrio cholerae) 		PF01408
(GFO_IDH_MocA) 		5 LEU A  86
VAL A  67
VAL A  59
TYR A  56
PRO A  89
 None
 1.47A 4kfbA-1xeaA:
0.0		 4kfbA-1xeaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 PRO A 243
VAL A 154
TYR A 151
PRO A  81
PHE A 383
 None
 1.48A 4kfbA-1z8lA:
0.9		 4kfbA-1z8lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9l VESICLE-ASSOCIATED
MEMBRANE
PROTEIN-ASSOCIATED
PROTEIN A

(Rattus
norvegicus) 		PF00635
(Motile_Sperm) 		5 LEU A 119
VAL A  71
VAL A  44
TYR A  52
PHE A  18
 None
 1.39A 4kfbA-1z9lA:
0.0		 4kfbA-1z9lA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5i CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		5 LEU C 140
VAL C 165
TYR C 197
TYR C 167
PHE C 186
 None
 1.44A 4kfbA-2b5iC:
0.0		 4kfbA-2b5iC:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erj CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		5 LEU C 140
VAL C 165
TYR C 197
TYR C 167
PHE C 186
 None
 1.35A 4kfbA-2erjC:
undetectable		 4kfbA-2erjC:
17.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
LYS A 103
TYR A 188
TRP A 229
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.3A)
 1.06A 4kfbA-2hnzA:
36.1		 4kfbA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
LYS A 103
VAL A 106
TYR A 181
TYR A 188
PRO A 236
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.3A)
PC0  A 999 (-4.3A)
 0.78A 4kfbA-2hnzA:
36.1		 4kfbA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
LYS A 103
VAL A 106
TYR A 188
PHE A 227
PRO A 236
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.1A)
PC0  A 999 (-4.7A)
PC0  A 999 ( 4.3A)
PC0  A 999 (-4.3A)
 0.89A 4kfbA-2hnzA:
36.1		 4kfbA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
VAL A 106
VAL A 179
TYR A 181
TYR A 188
PRO A 236
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.3A)
PC0  A 999 (-4.3A)
 0.78A 4kfbA-2hnzA:
36.1		 4kfbA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
VAL A 106
VAL A 179
TYR A 188
PHE A 227
PRO A 236
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-4.1A)
PC0  A 999 (-4.7A)
PC0  A 999 ( 4.3A)
PC0  A 999 (-4.3A)
 0.90A 4kfbA-2hnzA:
36.1		 4kfbA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
VAL A 179
TYR A 188
TRP A 229
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 (-4.4A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.3A)
 1.26A 4kfbA-2hnzA:
36.1		 4kfbA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 PRO A  95
LEU A 100
LYS A 103
VAL A 106
PRO A 225
PHE A 227
TRP A 229
PRO A 236
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
None
PC0  A 999 (-4.7A)
PC0  A 999 ( 4.2A)
PC0  A 999 ( 4.3A)
PC0  A 999 (-4.3A)
 0.70A 4kfbA-2hnzA:
36.1		 4kfbA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 PRO A  95
LEU A 100
LYS A 103
VAL A 106
TYR A 181
PRO A 236
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.3A)
PC0  A 999 (-4.3A)
 0.82A 4kfbA-2hnzA:
36.1		 4kfbA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 PRO A  95
LEU A 100
VAL A 106
VAL A 179
PRO A 225
PHE A 227
TRP A 229
PRO A 236
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
None
PC0  A 999 (-4.7A)
PC0  A 999 ( 4.2A)
PC0  A 999 ( 4.3A)
PC0  A 999 (-4.3A)
 0.70A 4kfbA-2hnzA:
36.1		 4kfbA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 PRO A  95
LEU A 100
VAL A 106
VAL A 179
TYR A 181
PRO A 236
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.3A)
PC0  A 999 (-4.3A)
 0.84A 4kfbA-2hnzA:
36.1		 4kfbA-2hnzA:
98.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3w PHYCOBILISOME ROD
LINKER POLYPEPTIDE

(Synechococcus
elongatus) 		PF00427
(PBS_linker_poly) 		5 LEU A  85
VAL A  21
TYR A  22
PHE A  54
TYR A 121
 None
 1.49A 4kfbA-2l3wA:
undetectable		 4kfbA-2l3wA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrt UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13905
(Thioredoxin_8) 		5 LEU A  76
VAL A 111
TYR A 105
TYR A 109
PHE A 118
 None
 1.08A 4kfbA-2lrtA:
undetectable		 4kfbA-2lrtA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2num UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT

(Rhodobacter
sphaeroides) 		PF00355
(Rieske) 		5 PRO A 174
LEU A 186
VAL A  54
VAL A  65
PHE A 178
 None
 1.47A 4kfbA-2numA:
undetectable		 4kfbA-2numA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 LEU A  42
TYR A 274
TYR A 271
PHE A  15
PRO A  10
 None
 1.25A 4kfbA-2o4cA:
undetectable		 4kfbA-2o4cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB

(Escherichia
coli) 		PF03888
(MucB_RseB)
PF17188
(MucB_RseB_C) 		5 LEU A  31
VAL A 170
TYR A 156
PRO A 112
PRO A 167
 None
 1.20A 4kfbA-2p4bA:
undetectable		 4kfbA-2p4bA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		5 PRO A 478
LEU A 128
VAL A 140
TYR A 126
PRO A 115
 None
 1.43A 4kfbA-2pyxA:
2.1		 4kfbA-2pyxA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus) 		PF13091
(PLDc_2) 		5 PRO A 124
LEU A 164
VAL A 274
PRO A 462
PRO A 347
 None
 1.49A 4kfbA-2ze4A:
undetectable		 4kfbA-2ze4A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd9 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF16806
(ExsD) 		5 LEU A 226
VAL A 256
VAL A 123
TRP A 274
PRO A 242
 None
 1.29A 4kfbA-3fd9A:
undetectable		 4kfbA-3fd9A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 PRO A 233
VAL A 144
TYR A 141
PRO A  71
PHE A 373
 None
 1.37A 4kfbA-3fedA:
undetectable		 4kfbA-3fedA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frn FLAGELLAR PROTEIN
FLGA

(Thermotoga
maritima) 		PF13144
(ChapFlgA) 		5 LEU A  56
VAL A 148
VAL A 139
PRO A 119
TYR A  58
 None
 1.47A 4kfbA-3frnA:
undetectable		 4kfbA-3frnA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhj MUTATOR MUTT PROTEIN

(Bartonella
henselae) 		PF14815
(NUDIX_4) 		5 PRO A  61
LEU A  75
VAL A  87
PHE A 113
PRO A  94
 None
 1.49A 4kfbA-3hhjA:
undetectable		 4kfbA-3hhjA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN

(Namalycastis
sp. ST01) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.22A 4kfbA-3l2eA:
3.0		 4kfbA-3l2eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		5 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.20A 4kfbA-3l7gA:
1.6		 4kfbA-3l7gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		5 LEU A  22
VAL A  45
TYR A 115
TYR A  43
PRO A 439
 None
 1.50A 4kfbA-3oepA:
4.5		 4kfbA-3oepA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bp8 OLIGOPEPTIDASE B

(Trypanosoma
brucei) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 PRO A 638
LEU A 640
VAL A 590
VAL A 569
PRO A 656
 None
 1.39A 4kfbA-4bp8A:
0.8		 4kfbA-4bp8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		5 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.48A 4kfbA-4by6A:
undetectable		 4kfbA-4by6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyl EFF-1A

(Caenorhabditis
elegans) 		PF14884
(EFF-AFF) 		5 PRO A 339
LEU A 404
VAL A 456
TYR A 482
PRO A 453
 None
 1.35A 4kfbA-4cylA:
1.1		 4kfbA-4cylA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		5 PRO A1214
VAL A1236
TYR A1261
TYR A1325
PHE A1327
 None
 1.47A 4kfbA-4i3hA:
3.8		 4kfbA-4i3hA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgt 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Homo sapiens) 		PF00581
(Rhodanese) 		5 PRO A 149
LEU A  89
VAL A 113
VAL A  97
TYR A  85
 None
 1.40A 4kfbA-4jgtA:
undetectable		 4kfbA-4jgtA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 250
VAL A 256
VAL A 213
TYR A 191
PRO A 254
 None
 1.12A 4kfbA-4jlwA:
undetectable		 4kfbA-4jlwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcj POLYSACCHARIDE
DEACETYLASE

(Ammonifex
degensii) 		PF01522
(Polysacc_deac_1) 		5 LEU A 242
VAL A  89
VAL A  40
TYR A  97
TYR A 219
 None
 1.34A 4kfbA-4wcjA:
1.5		 4kfbA-4wcjA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4s CHITOSANASE

(Mitsuaria
chitosanitabida) 		PF13647
(Glyco_hydro_80) 		5 LEU A  34
VAL A  14
TYR A  15
PRO A   8
TYR A  47
 None
 1.34A 4kfbA-5b4sA:
undetectable		 4kfbA-5b4sA:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LYS B 103
VAL B 106
VAL B 179
TYR B 181
TYR B 188
 None
 0.64A 4kfbA-5c24B:
10.7		 4kfbA-5c24B:
96.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evl BETA-LACTAMASE

(Chromobacterium
violaceum) 		PF00144
(Beta-lactamase) 		5 LEU A 110
VAL A 101
TYR A 136
PRO A 141
PRO A 145
 None
 1.35A 4kfbA-5evlA:
undetectable		 4kfbA-5evlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i32 AQUAPORIN TIP2-1

(Arabidopsis
thaliana) 		PF00230
(MIP) 		5 PRO A  84
LEU A 109
VAL A 206
PHE A 211
TRP A 218
 None
 1.30A 4kfbA-5i32A:
undetectable		 4kfbA-5i32A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 VAL A 214
VAL A 239
TYR A 237
PHE A 153
TYR A  45
 None
 1.25A 4kfbA-5xfmA:
undetectable		 4kfbA-5xfmA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhw PUTATIVE
6-DEOXY-D-MANNOHEPTO
SE PATHWAY PROTEIN

(Yersinia
pseudotuberculosis) 		no annotation 5 PRO A  25
LEU A  35
VAL A  75
PHE A  77
TYR A  36
 None
 1.47A 4kfbA-5xhwA:
undetectable		 4kfbA-5xhwA:
8.35