SIMILAR PATTERNS OF AMINO ACIDS FOR 4KF9_A_ACTA407_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bjn | PHOSPHOSERINEAMINOTRANSFERASE (Escherichiacoli) |
PF00266(Aminotran_5) | 3 | GLU A 316ARG A 360HIS A 361 | None | 0.85A | 4kf9A-1bjnA:0.0 | 4kf9A-1bjnA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dgs | DNA LIGASE (Thermusfiliformis) |
PF01653(DNA_ligase_aden)PF03120(DNA_ligase_OB)PF12826(HHH_2)PF14520(HHH_5) | 3 | GLU A 347ARG A 275HIS A 276 | None | 0.70A | 4kf9A-1dgsA:undetectable | 4kf9A-1dgsA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f20 | NITRIC-OXIDESYNTHASE (Rattusnorvegicus) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 3 | GLU A1187ARG A1016HIS A1189 | None | 0.75A | 4kf9A-1f20A:undetectable | 4kf9A-1f20A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g6q | HNRNP ARGININEN-METHYLTRANSFERASE (Saccharomycescerevisiae) |
PF06325(PrmA) | 3 | GLU 1 132ARG 1 42HIS 1 283 | None | 0.81A | 4kf9A-1g6q1:0.0 | 4kf9A-1g6q1:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ign | PROTEIN (RAP1) (Saccharomycescerevisiae) |
PF00249(Myb_DNA-binding)PF09197(Rap1-DNA-bind) | 3 | GLU A 453ARG A 447HIS A 536 | None | 0.83A | 4kf9A-1ignA:undetectable | 4kf9A-1ignA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jad | PHOSPHOLIPASE C BETA (Meleagrisgallopavo) |
PF06631(DUF1154)PF08703(PLC-beta_C) | 3 | GLU A 37ARG A 98HIS A 102 | None | 0.70A | 4kf9A-1jadA:undetectable | 4kf9A-1jadA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m22 | PEPTIDE AMIDASE (Stenotrophomonasmaltophilia) |
PF01425(Amidase) | 3 | GLU A 105ARG A 112HIS A 116 | None | 0.83A | 4kf9A-1m22A:0.0 | 4kf9A-1m22A:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m7j | D-AMINOACYLASE (Alcaligenesfaecalis) |
PF07969(Amidohydro_3) | 3 | GLU A 202ARG A 152HIS A 148 | None | 0.85A | 4kf9A-1m7jA:0.0 | 4kf9A-1m7jA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mty | METHANEMONOOXYGENASEHYDROXYLASE (Methylococcuscapsulatus) |
PF02964(MeMO_Hyd_G) | 3 | GLU G 132ARG G 115HIS G 111 | None | 0.58A | 4kf9A-1mtyG:0.0 | 4kf9A-1mtyG:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q2y | SIMILAR TOHYPOTHETICALPROTEINS (Bacillussubtilis) |
PF13673(Acetyltransf_10) | 3 | GLU A 39ARG A 58HIS A 44 | None | 0.86A | 4kf9A-1q2yA:undetectable | 4kf9A-1q2yA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sjj | ACTININ (Gallus gallus) |
PF00307(CH)PF00435(Spectrin)PF08726(EFhand_Ca_insen) | 3 | GLU A 630ARG A 633HIS A 706 | None | 0.34A | 4kf9A-1sjjA:undetectable | 4kf9A-1sjjA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tmo | TRIMETHYLAMINEN-OXIDE REDUCTASE (Shewanellamassilia) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 3 | GLU A 165ARG A 586HIS A 587 | None | 0.72A | 4kf9A-1tmoA:undetectable | 4kf9A-1tmoA:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uou | THYMIDINEPHOSPHORYLASE (Homo sapiens) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N)PF07831(PYNP_C) | 3 | GLU A 422ARG A 439HIS A 441 | None | 0.71A | 4kf9A-1uouA:undetectable | 4kf9A-1uouA:24.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9p | DNA LIGASE (Thermusfiliformis) |
PF01653(DNA_ligase_aden)PF03120(DNA_ligase_OB)PF12826(HHH_2)PF14520(HHH_5) | 3 | GLU A 350ARG A 278HIS A 279 | None | 0.66A | 4kf9A-1v9pA:undetectable | 4kf9A-1v9pA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vjk | MOLYBDOPTERINCONVERTING FACTOR,SUBUNIT 1 (Pyrococcusfuriosus) |
PF02597(ThiS) | 3 | GLU A 21ARG A 41HIS A 42 | None | 0.78A | 4kf9A-1vjkA:undetectable | 4kf9A-1vjkA:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w9c | CRM1 PROTEIN (Homo sapiens) |
PF08767(CRM1_C) | 3 | GLU A 839ARG A 845HIS A 884 | None | 0.58A | 4kf9A-1w9cA:2.2 | 4kf9A-1w9cA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yrw | PROTEIN ARNA (Escherichiacoli) |
PF00551(Formyl_trans_N)PF02911(Formyl_trans_C) | 3 | GLU A 275ARG A 246HIS A 248 | None | 0.84A | 4kf9A-1yrwA:undetectable | 4kf9A-1yrwA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z6o | FERRITIN LIGHT CHAIN (Trichoplusia ni) |
PF00210(Ferritin) | 3 | GLU A 158ARG A 97HIS A 93 | None | 0.85A | 4kf9A-1z6oA:undetectable | 4kf9A-1z6oA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zvd | SMAD UBIQUITINATIONREGULATORY FACTOR 2 (Homo sapiens) |
PF00632(HECT) | 3 | GLU A 607ARG A 488HIS A 484 | None | 0.74A | 4kf9A-1zvdA:undetectable | 4kf9A-1zvdA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dy3 | ALANINE RACEMASE (Corynebacteriumglutamicum) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 3 | GLU A 151ARG A 118HIS A 116 | None | 0.83A | 4kf9A-2dy3A:undetectable | 4kf9A-2dy3A:24.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hau | SEROTRANSFERRIN (Homo sapiens) |
PF00405(Transferrin) | 3 | GLU A 419ARG A 602HIS A 606 | None | 0.87A | 4kf9A-2hauA:undetectable | 4kf9A-2hauA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hfs | MEVALONATE KINASE,PUTATIVE (Leishmaniamajor) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 3 | GLU A 264ARG A 254HIS A 250 | None | 0.77A | 4kf9A-2hfsA:undetectable | 4kf9A-2hfsA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2igt | SAM DEPENDENTMETHYLTRANSFERASE (Agrobacteriumfabrum) |
PF10672(Methyltrans_SAM) | 3 | GLU A 10ARG A 267HIS A 263 | None | 0.80A | 4kf9A-2igtA:undetectable | 4kf9A-2igtA:24.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgp | TYROCIDINESYNTHETASE 3 (Brevibacillusbrevis) |
PF00550(PP-binding)PF00668(Condensation) | 3 | GLU A 238ARG A 148HIS A 149 | None | 0.79A | 4kf9A-2jgpA:undetectable | 4kf9A-2jgpA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n03 | PLECTIN (Homo sapiens) |
PF00681(Plectin) | 3 | GLU A4450ARG A4447HIS A4394 | None | 0.84A | 4kf9A-2n03A:undetectable | 4kf9A-2n03A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qp2 | UNKNOWN PROTEIN (Photorhabduslaumondii) |
PF01823(MACPF) | 3 | GLU A 20ARG A 17HIS A 267 | None | 0.84A | 4kf9A-2qp2A:undetectable | 4kf9A-2qp2A:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qrx | GM27569P (Drosophilamelanogaster) |
PF01997(Translin) | 3 | GLU A 151ARG A 154HIS A 49 | None | 0.74A | 4kf9A-2qrxA:undetectable | 4kf9A-2qrxA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r4j | AEROBICGLYCEROL-3-PHOSPHATEDEHYDROGENASE (Escherichiacoli) |
PF01266(DAO)PF16901(DAO_C) | 3 | GLU A 251ARG A 92HIS A 94 | None | 0.81A | 4kf9A-2r4jA:undetectable | 4kf9A-2r4jA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vif | SUPPRESSOR OFCYTOKINE SIGNALLING6 (Homo sapiens) |
PF00017(SH2) | 3 | GLU A 395ARG A 391HIS A 430 | None | 0.85A | 4kf9A-2vifA:undetectable | 4kf9A-2vifA:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vkt | CTP SYNTHASE 2 (Homo sapiens) |
PF00117(GATase) | 3 | GLU A 510ARG A 449HIS A 480 | None | 0.78A | 4kf9A-2vktA:undetectable | 4kf9A-2vktA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wqd | PHOSPHOENOLPYRUVATE-PROTEINPHOSPHOTRANSFERASE (Staphylococcusaureus) |
PF00391(PEP-utilizers)PF02896(PEP-utilizers_C)PF05524(PEP-utilisers_N) | 3 | GLU A 55ARG A 138HIS A 142 | None | 0.68A | 4kf9A-2wqdA:undetectable | 4kf9A-2wqdA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsj | P-COUMARIC ACIDDECARBOXYLASE (Lactobacillusplantarum) |
PF05870(PA_decarbox) | 3 | GLU A 27ARG A 39HIS A 41 | None | 0.82A | 4kf9A-2wsjA:undetectable | 4kf9A-2wsjA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wwd | 1,4-BETA-N-ACETYLMURAMIDASE (Streptococcuspneumoniae) |
PF01183(Glyco_hydro_25)PF01473(CW_binding_1) | 3 | GLU A 292ARG A 253HIS A 248 | NoneGOL A 607 (-3.4A)None | 0.85A | 4kf9A-2wwdA:undetectable | 4kf9A-2wwdA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xts | SULFITEDEHYDROGENASE (Paracoccuspantotrophus) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 3 | GLU A 102ARG A 366HIS A 368 | GOL A1433 ( 4.9A)GOL A1433 ( 4.9A)None | 0.77A | 4kf9A-2xtsA:undetectable | 4kf9A-2xtsA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y30 | PUTATIVE REPRESSORSIMREG2 (Streptomycesantibioticus) |
PF00440(TetR_N)PF02909(TetR_C) | 3 | GLU A 85ARG A 113HIS A 114 | None | 0.73A | 4kf9A-2y30A:undetectable | 4kf9A-2y30A:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3afl | OLIGO ALGINATE LYASE (Agrobacteriumfabrum) |
PF07940(Hepar_II_III)PF16332(DUF4962) | 3 | GLU A 632ARG A 610HIS A 634 | None | 0.74A | 4kf9A-3aflA:undetectable | 4kf9A-3aflA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ble | CITRAMALATE SYNTHASEFROM LEPTOSPIRAINTERROGANS (Leptospirainterrogans) |
PF00682(HMGL-like) | 3 | GLU A 9ARG A 173HIS A 203 | None | 0.80A | 4kf9A-3bleA:undetectable | 4kf9A-3bleA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmb | ACETOACETATEDECARBOXYLASE (Methanoculleusmarisnigri) |
PF06314(ADC) | 3 | GLU A 54ARG A 88HIS A 90 | None | 0.81A | 4kf9A-3cmbA:undetectable | 4kf9A-3cmbA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmm | UBIQUITIN-ACTIVATINGENZYME E1 1 (Saccharomycescerevisiae) |
PF00899(ThiF)PF09358(E1_UFD)PF10585(UBA_e1_thiolCys)PF16190(E1_FCCH)PF16191(E1_4HB) | 3 | GLU A 321ARG A 305HIS A 306 | None | 0.87A | 4kf9A-3cmmA:undetectable | 4kf9A-3cmmA:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e97 | TRANSCRIPTIONALREGULATOR, CRP/FNRFAMILY (Deinococcusgeothermalis) |
PF00027(cNMP_binding)PF13545(HTH_Crp_2) | 3 | GLU A 23ARG A 117HIS A 118 | None | 0.85A | 4kf9A-3e97A:undetectable | 4kf9A-3e97A:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egc | PUTATIVE RIBOSEOPERON REPRESSOR (Burkholderiathailandensis) |
PF00532(Peripla_BP_1) | 3 | GLU A 276ARG A 182HIS A 184 | None | 0.86A | 4kf9A-3egcA:undetectable | 4kf9A-3egcA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gip | N-ACYL-D-GLUTAMATEDEACYLASE (Bordetellabronchiseptica) |
PF07969(Amidohydro_3) | 3 | GLU A 200ARG A 150HIS A 146 | None | 0.85A | 4kf9A-3gipA:undetectable | 4kf9A-3gipA:25.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1l | MITOCHONDRIALCYTOCHROME C1, HEMEPROTEIN (Gallus gallus) |
PF02167(Cytochrom_C1) | 3 | GLU D 124ARG D 191HIS D 14 | None | 0.85A | 4kf9A-3h1lD:undetectable | 4kf9A-3h1lD:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hqg | TYPE-2 RESTRICTIONENZYME ECORII (Escherichiacoli) |
PF09019(EcoRII-C) | 3 | GLU A 225ARG A 222HIS A 273 | None | 0.85A | 4kf9A-3hqgA:undetectable | 4kf9A-3hqgA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hzj | RABGTPASE-ACTIVATINGPROTEIN 1-LIKE (Homo sapiens) |
PF00566(RabGAP-TBC) | 3 | GLU A 541ARG A 544HIS A 633 | None | 0.75A | 4kf9A-3hzjA:undetectable | 4kf9A-3hzjA:25.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ic8 | UNCHARACTERIZEDGST-LIKEPROTEINPROTEIN (Pseudomonassyringae groupgenomosp. 3) |
PF13410(GST_C_2)PF13417(GST_N_3) | 3 | GLU A 16ARG A 19HIS A 220 | None | 0.33A | 4kf9A-3ic8A:35.1 | 4kf9A-3ic8A:46.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzh | PROBABLE SUGARKINASE (Clostridiumperfringens) |
PF00294(PfkB) | 3 | GLU A 50ARG A 46HIS A 77 | None | 0.86A | 4kf9A-3kzhA:undetectable | 4kf9A-3kzhA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lg5 | EPI-ISOZIZAENESYNTHASE (Streptomycescoelicolor) |
no annotation | 3 | GLU A 234ARG A 195HIS A 200 | None | 0.83A | 4kf9A-3lg5A:undetectable | 4kf9A-3lg5A:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lh5 | TIGHT JUNCTIONPROTEIN ZO-1 (Homo sapiens) |
PF00625(Guanylate_kin)PF07653(SH3_2) | 3 | GLU A 634ARG A 522HIS A 524 | None | 0.85A | 4kf9A-3lh5A:undetectable | 4kf9A-3lh5A:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6x | RRNA METHYLASE (Thermusthermophilus) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 3 | GLU A 17ARG A 286HIS A 285 | None | 0.82A | 4kf9A-3m6xA:undetectable | 4kf9A-3m6xA:24.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n3t | PUTATIVE DIGUANYLATECYCLASE/PHOSPHODIESTERASE (Thiobacillusdenitrificans) |
PF00563(EAL) | 3 | GLU A 614ARG A 642HIS A 664 | None | 0.66A | 4kf9A-3n3tA:undetectable | 4kf9A-3n3tA:24.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oq3 | IFN-ALPHA/BETABINDING PROTEIN C12R (Ectromeliavirus) |
PF00047(ig)PF13895(Ig_2) | 3 | GLU B 4ARG B 61HIS B 60 | None | 0.56A | 4kf9A-3oq3B:undetectable | 4kf9A-3oq3B:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pds | FUSION PROTEINBETA-2 ADRENERGICRECEPTOR/LYSOZYME (Homo sapiens;Escherichiavirus T4) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | GLU A 107ARG A 175HIS A 172 | None | 0.87A | 4kf9A-3pdsA:undetectable | 4kf9A-3pdsA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qb5 | TRANSLIN-ASSOCIATEDPROTEIN X (Homo sapiens) |
PF01997(Translin) | 3 | GLU K 197ARG K 200HIS K 75 | MN K 291 (-3.3A)SO4 K 293 (-3.4A)None | 0.81A | 4kf9A-3qb5K:undetectable | 4kf9A-3qb5K:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rob | UNCHARACTERIZEDCONSERVED PROTEIN (Planctopiruslimnophila) |
PF14534(DUF4440) | 3 | GLU A 78ARG A 90HIS A 111 | None | 0.74A | 4kf9A-3robA:undetectable | 4kf9A-3robA:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s7x | MAJOR CAPSID PROTEINVP1 (Humanpolyomavirus 4) |
PF00718(Polyoma_coat) | 3 | GLU A 123ARG A 286HIS A 288 | None | 0.83A | 4kf9A-3s7xA:undetectable | 4kf9A-3s7xA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3shw | TIGHT JUNCTIONPROTEIN ZO-1 (Homo sapiens) |
PF00595(PDZ)PF00625(Guanylate_kin)PF07653(SH3_2) | 3 | GLU A 634ARG A 522HIS A 524 | None | 0.87A | 4kf9A-3shwA:undetectable | 4kf9A-3shwA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t3a | KILLER CELLLECTIN-LIKE RECEPTORSUBFAMILY B MEMBER1A (Mus musculus) |
PF00059(Lectin_C) | 3 | GLU A 136ARG A 102HIS A 101 | None | 0.78A | 4kf9A-3t3aA:undetectable | 4kf9A-3t3aA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsw | TIGHT JUNCTIONPROTEIN ZO-1 (Homo sapiens) |
PF00595(PDZ)PF00625(Guanylate_kin)PF07653(SH3_2) | 3 | GLU A 634ARG A 522HIS A 524 | None | 0.86A | 4kf9A-3tswA:undetectable | 4kf9A-3tswA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3umm | PHOSPHORIBOSYLFORMYLGLYCINAMIDINESYNTHASE (Salmonellaenterica) |
PF02769(AIRS_C)PF13507(GATase_5) | 3 | GLU A 483ARG A1046HIS A1053 | None | 0.63A | 4kf9A-3ummA:undetectable | 4kf9A-3ummA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va7 | KLLA0E08119P (Kluyveromyceslactis) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF02626(CT_A_B)PF02682(CT_C_D)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 3 | GLU A1507ARG A1467HIS A1468 | None | 0.86A | 4kf9A-3va7A:undetectable | 4kf9A-3va7A:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a1f | REPLICATIVE DNAHELICASE (Helicobacterpylori) |
PF03796(DnaB_C) | 3 | GLU A 437ARG A 456HIS A 472 | None | 0.85A | 4kf9A-4a1fA:undetectable | 4kf9A-4a1fA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b2n | 70 KDA PROTEIN (Xanthomonas sp.35Y) |
no annotation | 3 | GLU A 337ARG A 84HIS A 71 | None | 0.79A | 4kf9A-4b2nA:undetectable | 4kf9A-4b2nA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dsh | UDP-GALACTOPYRANOSEMUTASE (Trypanosomacruzi) |
PF01593(Amino_oxidase)PF13450(NAD_binding_8) | 3 | GLU A 352ARG A 390HIS A 360 | NoneNoneSO4 A 505 (-3.9A) | 0.62A | 4kf9A-4dshA:undetectable | 4kf9A-4dshA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dzi | PUTATIVE TIM-BARRELMETAL-DEPENDENTHYDROLASE (Mycobacteriumavium) |
PF04909(Amidohydro_2) | 3 | GLU A 151ARG A 24HIS A 25 | None | 0.84A | 4kf9A-4dziA:undetectable | 4kf9A-4dziA:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0x | MALONYL-COADECARBOXYLASE,MITOCHONDRIAL (Homo sapiens) |
PF05292(MCD)PF17408(MCD_N) | 3 | GLU A 216ARG A 230HIS A 254 | None | 0.80A | 4kf9A-4f0xA:1.6 | 4kf9A-4f0xA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g1c | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Homo sapiens) |
PF02146(SIR2) | 3 | GLU A 238ARG A 134HIS A 52 | None | 0.86A | 4kf9A-4g1cA:undetectable | 4kf9A-4g1cA:23.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4kf9 | GLUTATHIONES-TRANSFERASEPROTEIN (Ralstoniasolanacearum) |
PF13410(GST_C_2)PF13417(GST_N_3) | 3 | GLU A 18ARG A 21HIS A 224 | ZN A 401 ( 1.9A)ACT A 407 (-3.6A) ZN A 401 ( 3.2A) | 0.00A | 4kf9A-4kf9A:55.5 | 4kf9A-4kf9A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4knh | NUP192P (Chaetomiumthermophilum) |
PF11894(Nup192) | 3 | GLU A 161ARG A 252HIS A 254 | None | 0.69A | 4kf9A-4knhA:1.1 | 4kf9A-4knhA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lob | POLYPRENYLSYNTHETASE (Acinetobacterbaumannii) |
PF00348(polyprenyl_synt) | 3 | GLU A 180ARG A 177HIS A 172 | GOL A 401 (-2.7A)NoneGOL A 401 (-3.7A) | 0.69A | 4kf9A-4lobA:undetectable | 4kf9A-4lobA:24.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ml9 | UNCHARACTERIZEDPROTEIN (Sebaldellatermitidis) |
PF00977(His_biosynth) | 3 | GLU A 114ARG A 79HIS A 57 | None | 0.79A | 4kf9A-4ml9A:undetectable | 4kf9A-4ml9A:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nc6 | RABGTPASE-ACTIVATINGPROTEIN 1 (Homo sapiens) |
PF00566(RabGAP-TBC) | 3 | GLU A 569ARG A 572HIS A 661 | None | 0.68A | 4kf9A-4nc6A:undetectable | 4kf9A-4nc6A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pch | VP1 (Humanpolyomavirus 7) |
PF00718(Polyoma_coat) | 3 | GLU A 104ARG A 278HIS A 280 | None | 0.80A | 4kf9A-4pchA:undetectable | 4kf9A-4pchA:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s0v | HUMAN OREXINRECEPTOR TYPE 2FUSION PROTEIN TO P.ABYSII GLYCOGENSYNTHASE (Homo sapiens;Pyrococcusabyssi) |
PF00001(7tm_1)PF00534(Glycos_transf_1) | 3 | GLU A 212ARG A 328HIS A 224 | SUV A2001 (-4.1A)NoneSUV A2001 ( 4.8A) | 0.76A | 4kf9A-4s0vA:undetectable | 4kf9A-4s0vA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uu2 | FERULIC ACIDDECARBOXYLASE (Enterobactersp.) |
PF05870(PA_decarbox) | 3 | GLU A 28ARG A 40HIS A 42 | None | 0.86A | 4kf9A-4uu2A:undetectable | 4kf9A-4uu2A:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v1y | ATRAZINECHLOROHYDROLASE (Pseudomonas sp.ADP) |
PF01979(Amidohydro_1) | 3 | GLU A 263ARG A 290HIS A 291 | None | 0.75A | 4kf9A-4v1yA:undetectable | 4kf9A-4v1yA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zj8 | HUMAN OX1R FUSIONPROTEIN TO P.ABYSIIGLYCOGEN SYNTHASE (Homo sapiens;Pyrococcusabyssi) |
PF00001(7tm_1)PF00534(Glycos_transf_1) | 3 | GLU A 204ARG A 322HIS A 216 | SUV A2001 (-4.4A)NoneSUV A2001 ( 4.8A) | 0.82A | 4kf9A-4zj8A:undetectable | 4kf9A-4zj8A:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ao8 | SOLUBLE LYTICTRANGLYCOSILASE B3 (Pseudomonasaeruginosa) |
PF01471(PG_binding_1)PF13406(SLT_2) | 3 | GLU A 401ARG A 376HIS A 378 | None | 0.69A | 4kf9A-5ao8A:undetectable | 4kf9A-5ao8A:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5g | PUTATIVE XANTHINEDEHYDROGENASE YAGSFAD-BINDING SUBUNIT (Escherichiacoli) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 3 | GLU C 462ARG C 450HIS C 452 | None | 0.78A | 4kf9A-5g5gC:undetectable | 4kf9A-5g5gC:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gvx | TREHALOSE-PHOSPHATEPHOSPHATASE (Mycobacteriumtuberculosis) |
PF02358(Trehalose_PPase) | 3 | GLU A 237ARG A 282HIS A 283 | None | 0.81A | 4kf9A-5gvxA:undetectable | 4kf9A-5gvxA:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hy7 | PUTATIVE PRE-MRNASPLICING PROTEIN (Chaetomiumthermophilum) |
PF03178(CPSF_A)PF10433(MMS1_N) | 3 | GLU A 554ARG A 545HIS A 540 | None | 0.78A | 4kf9A-5hy7A:undetectable | 4kf9A-5hy7A:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3a | TYROSINASE (Bacillusmegaterium) |
PF00264(Tyrosinase) | 3 | GLU A 289ARG A 280HIS A 279 | None | 0.82A | 4kf9A-5i3aA:undetectable | 4kf9A-5i3aA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i5j | NITROUS-OXIDEREDUCTASE (Shewanelladenitrificans) |
no annotation | 3 | GLU A 431ARG A 177HIS A 128 | None | 0.86A | 4kf9A-5i5jA:undetectable | 4kf9A-5i5jA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i61 | POTENTIALRNA-DEPENDENT RNAPOLYMERASE (Humanpicobirnavirus) |
no annotation | 3 | GLU B 341ARG B 379HIS B 380 | None | 0.61A | 4kf9A-5i61B:undetectable | 4kf9A-5i61B:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kr6 | 4-AMINOBUTYRATETRANSAMINASE (Pseudomonas) |
PF00202(Aminotran_3) | 3 | GLU A 386ARG A 190HIS A 187 | None | 0.75A | 4kf9A-5kr6A:undetectable | 4kf9A-5kr6A:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l7s | SECRETED RXLREFFECTOR PEPTIDEPROTEIN (Phytophthorainfestans) |
no annotation | 3 | GLU A 315ARG A 279HIS A 276 | None | 0.85A | 4kf9A-5l7sA:undetectable | 4kf9A-5l7sA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lon | KLLA0E01827P (Kluyveromyceslactis) |
PF06058(DCP1) | 3 | GLU B 7ARG B 10HIS B 31 | None | 0.85A | 4kf9A-5lonB:undetectable | 4kf9A-5lonB:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mb4 | GLCNAC SPECIFICLECTIN (Psathyrella) |
PF13517(VCBS) | 3 | GLU A 191ARG A 170HIS A 171 | NoneMLI A 507 (-3.8A)NDG A 509 ( 3.9A) | 0.85A | 4kf9A-5mb4A:undetectable | 4kf9A-5mb4A:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqm | GLYCOSYL HYDROLASESFAMILY 2, SUGARBINDING DOMAIN (Bacteroidesthetaiotaomicron) |
PF17132(Glyco_hydro_106) | 3 | GLU A 239ARG A 326HIS A 328 | None | 0.82A | 4kf9A-5mqmA:undetectable | 4kf9A-5mqmA:14.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tus | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASELARGE SUBUNIT (Homo sapiens) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF03477(ATP-cone) | 3 | GLU A 440ARG A 497HIS A 498 | None | 0.72A | 4kf9A-5tusA:undetectable | 4kf9A-5tusA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u03 | CTP SYNTHASE 1 (Homo sapiens) |
PF00117(GATase)PF06418(CTP_synth_N) | 3 | GLU A 510ARG A 449HIS A 480 | None | 0.70A | 4kf9A-5u03A:undetectable | 4kf9A-5u03A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u8z | CAROTENOID OXYGENASE1 (Neurosporacrassa) |
PF03055(RPE65) | 3 | GLU A 213ARG A 134HIS A 277 | None | 0.79A | 4kf9A-5u8zA:undetectable | 4kf9A-5u8zA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v36 | GLUTATHIONEREDUCTASE (Streptococcusmutans) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 3 | GLU A 323ARG A 22HIS A 26 | SO4 A 519 ( 4.8A)SO4 A 519 ( 3.0A)None | 0.70A | 4kf9A-5v36A:undetectable | 4kf9A-5v36A:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vha | DEAH(ASP-GLU-ALA-HIS)BOX POLYPEPTIDE 36 (Bos taurus) |
no annotation | 3 | GLU A 576ARG A 635HIS A 578 | None | 0.82A | 4kf9A-5vhaA:undetectable | 4kf9A-5vhaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y7y | ARYL HYDROCARBONRECEPTOR REPRESSORARYL HYDROCARBONRECEPTOR NUCLEARTRANSLOCATOR (Homo sapiens;Bos taurus) |
PF00010(HLH)PF00989(PAS)PF00010(HLH)PF00989(PAS)PF14598(PAS_11) | 3 | GLU B 111ARG A 79HIS A 156 | NoneGOL A 301 ( 4.3A)None | 0.43A | 4kf9A-5y7yB:undetectable | 4kf9A-5y7yB:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z96 | SHORT TRANSIENTRECEPTOR POTENTIALCHANNEL 4 (Mus musculus) |
no annotation | 3 | GLU A 138ARG A 105HIS A 102 | None | 0.56A | 4kf9A-5z96A:undetectable | 4kf9A-5z96A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b4o | GLUTATHIONEREDUCTASE (Enterococcusfaecalis) |
no annotation | 3 | GLU A 322ARG A 21HIS A 25 | None | 0.73A | 4kf9A-6b4oA:undetectable | 4kf9A-6b4oA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6chj | DIACYLGLYCEROLO-ACYLTRANSFERASE (Marinobacterhydrocarbonoclasticus) |
no annotation | 3 | GLU A 116ARG A 83HIS A 118 | CL A 502 (-3.8A) CL A 501 ( 4.7A)None | 0.73A | 4kf9A-6chjA:undetectable | 4kf9A-6chjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6enz | ACIDIC AMINO ACIDDECARBOXYLASE GADL1 (Mus musculus) |
no annotation | 3 | GLU A 198ARG A 468HIS A 467 | None | 0.73A | 4kf9A-6enzA:undetectable | 4kf9A-6enzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fyd | PUTATIVEFAD-DEPENDENTOXYGENASE ENCM (Streptomycesmaritimus) |
no annotation | 3 | GLU A 393ARG A 396HIS A 397 | None | 0.81A | 4kf9A-6fydA:undetectable | 4kf9A-6fydA:undetectable |