SIMILAR PATTERNS OF AMINO ACIDS FOR 4KF9_A_ACTA407

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE


(Escherichia
coli)
PF00266
(Aminotran_5)
3 GLU A 316
ARG A 360
HIS A 361
None
0.85A 4kf9A-1bjnA:
0.0
4kf9A-1bjnA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis)
PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5)
3 GLU A 347
ARG A 275
HIS A 276
None
0.70A 4kf9A-1dgsA:
undetectable
4kf9A-1dgsA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE


(Rattus
norvegicus)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
3 GLU A1187
ARG A1016
HIS A1189
None
0.75A 4kf9A-1f20A:
undetectable
4kf9A-1f20A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6q HNRNP ARGININE
N-METHYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF06325
(PrmA)
3 GLU 1 132
ARG 1  42
HIS 1 283
None
0.81A 4kf9A-1g6q1:
0.0
4kf9A-1g6q1:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ign PROTEIN (RAP1)

(Saccharomyces
cerevisiae)
PF00249
(Myb_DNA-binding)
PF09197
(Rap1-DNA-bind)
3 GLU A 453
ARG A 447
HIS A 536
None
0.83A 4kf9A-1ignA:
undetectable
4kf9A-1ignA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jad PHOSPHOLIPASE C BETA

(Meleagris
gallopavo)
PF06631
(DUF1154)
PF08703
(PLC-beta_C)
3 GLU A  37
ARG A  98
HIS A 102
None
0.70A 4kf9A-1jadA:
undetectable
4kf9A-1jadA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia)
PF01425
(Amidase)
3 GLU A 105
ARG A 112
HIS A 116
None
0.83A 4kf9A-1m22A:
0.0
4kf9A-1m22A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis)
PF07969
(Amidohydro_3)
3 GLU A 202
ARG A 152
HIS A 148
None
0.85A 4kf9A-1m7jA:
0.0
4kf9A-1m7jA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE


(Methylococcus
capsulatus)
PF02964
(MeMO_Hyd_G)
3 GLU G 132
ARG G 115
HIS G 111
None
0.58A 4kf9A-1mtyG:
0.0
4kf9A-1mtyG:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2y SIMILAR TO
HYPOTHETICAL
PROTEINS


(Bacillus
subtilis)
PF13673
(Acetyltransf_10)
3 GLU A  39
ARG A  58
HIS A  44
None
0.86A 4kf9A-1q2yA:
undetectable
4kf9A-1q2yA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjj ACTININ

(Gallus gallus)
PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen)
3 GLU A 630
ARG A 633
HIS A 706
None
0.34A 4kf9A-1sjjA:
undetectable
4kf9A-1sjjA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE


(Shewanella
massilia)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
3 GLU A 165
ARG A 586
HIS A 587
None
0.72A 4kf9A-1tmoA:
undetectable
4kf9A-1tmoA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uou THYMIDINE
PHOSPHORYLASE


(Homo sapiens)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
3 GLU A 422
ARG A 439
HIS A 441
None
0.71A 4kf9A-1uouA:
undetectable
4kf9A-1uouA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis)
PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5)
3 GLU A 350
ARG A 278
HIS A 279
None
0.66A 4kf9A-1v9pA:
undetectable
4kf9A-1v9pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjk MOLYBDOPTERIN
CONVERTING FACTOR,
SUBUNIT 1


(Pyrococcus
furiosus)
PF02597
(ThiS)
3 GLU A  21
ARG A  41
HIS A  42
None
0.78A 4kf9A-1vjkA:
undetectable
4kf9A-1vjkA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9c CRM1 PROTEIN

(Homo sapiens)
PF08767
(CRM1_C)
3 GLU A 839
ARG A 845
HIS A 884
None
0.58A 4kf9A-1w9cA:
2.2
4kf9A-1w9cA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli)
PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C)
3 GLU A 275
ARG A 246
HIS A 248
None
0.84A 4kf9A-1yrwA:
undetectable
4kf9A-1yrwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6o FERRITIN LIGHT CHAIN

(Trichoplusia ni)
PF00210
(Ferritin)
3 GLU A 158
ARG A  97
HIS A  93
None
0.85A 4kf9A-1z6oA:
undetectable
4kf9A-1z6oA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2


(Homo sapiens)
PF00632
(HECT)
3 GLU A 607
ARG A 488
HIS A 484
None
0.74A 4kf9A-1zvdA:
undetectable
4kf9A-1zvdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
3 GLU A 151
ARG A 118
HIS A 116
None
0.83A 4kf9A-2dy3A:
undetectable
4kf9A-2dy3A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hau SEROTRANSFERRIN

(Homo sapiens)
PF00405
(Transferrin)
3 GLU A 419
ARG A 602
HIS A 606
None
0.87A 4kf9A-2hauA:
undetectable
4kf9A-2hauA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfs MEVALONATE KINASE,
PUTATIVE


(Leishmania
major)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
3 GLU A 264
ARG A 254
HIS A 250
None
0.77A 4kf9A-2hfsA:
undetectable
4kf9A-2hfsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE


(Agrobacterium
fabrum)
PF10672
(Methyltrans_SAM)
3 GLU A  10
ARG A 267
HIS A 263
None
0.80A 4kf9A-2igtA:
undetectable
4kf9A-2igtA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3


(Brevibacillus
brevis)
PF00550
(PP-binding)
PF00668
(Condensation)
3 GLU A 238
ARG A 148
HIS A 149
None
0.79A 4kf9A-2jgpA:
undetectable
4kf9A-2jgpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n03 PLECTIN

(Homo sapiens)
PF00681
(Plectin)
3 GLU A4450
ARG A4447
HIS A4394
None
0.84A 4kf9A-2n03A:
undetectable
4kf9A-2n03A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii)
PF01823
(MACPF)
3 GLU A  20
ARG A  17
HIS A 267
None
0.84A 4kf9A-2qp2A:
undetectable
4kf9A-2qp2A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qrx GM27569P

(Drosophila
melanogaster)
PF01997
(Translin)
3 GLU A 151
ARG A 154
HIS A  49
None
0.74A 4kf9A-2qrxA:
undetectable
4kf9A-2qrxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Escherichia
coli)
PF01266
(DAO)
PF16901
(DAO_C)
3 GLU A 251
ARG A  92
HIS A  94
None
0.81A 4kf9A-2r4jA:
undetectable
4kf9A-2r4jA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vif SUPPRESSOR OF
CYTOKINE SIGNALLING
6


(Homo sapiens)
PF00017
(SH2)
3 GLU A 395
ARG A 391
HIS A 430
None
0.85A 4kf9A-2vifA:
undetectable
4kf9A-2vifA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkt CTP SYNTHASE 2

(Homo sapiens)
PF00117
(GATase)
3 GLU A 510
ARG A 449
HIS A 480
None
0.78A 4kf9A-2vktA:
undetectable
4kf9A-2vktA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqd PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE


(Staphylococcus
aureus)
PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N)
3 GLU A  55
ARG A 138
HIS A 142
None
0.68A 4kf9A-2wqdA:
undetectable
4kf9A-2wqdA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsj P-COUMARIC ACID
DECARBOXYLASE


(Lactobacillus
plantarum)
PF05870
(PA_decarbox)
3 GLU A  27
ARG A  39
HIS A  41
None
0.82A 4kf9A-2wsjA:
undetectable
4kf9A-2wsjA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE


(Streptococcus
pneumoniae)
PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1)
3 GLU A 292
ARG A 253
HIS A 248
None
GOL  A 607 (-3.4A)
None
0.85A 4kf9A-2wwdA:
undetectable
4kf9A-2wwdA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts SULFITE
DEHYDROGENASE


(Paracoccus
pantotrophus)
PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer)
3 GLU A 102
ARG A 366
HIS A 368
GOL  A1433 ( 4.9A)
GOL  A1433 ( 4.9A)
None
0.77A 4kf9A-2xtsA:
undetectable
4kf9A-2xtsA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y30 PUTATIVE REPRESSOR
SIMREG2


(Streptomyces
antibioticus)
PF00440
(TetR_N)
PF02909
(TetR_C)
3 GLU A  85
ARG A 113
HIS A 114
None
0.73A 4kf9A-2y30A:
undetectable
4kf9A-2y30A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum)
PF07940
(Hepar_II_III)
PF16332
(DUF4962)
3 GLU A 632
ARG A 610
HIS A 634
None
0.74A 4kf9A-3aflA:
undetectable
4kf9A-3aflA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ble CITRAMALATE SYNTHASE
FROM LEPTOSPIRA
INTERROGANS


(Leptospira
interrogans)
PF00682
(HMGL-like)
3 GLU A   9
ARG A 173
HIS A 203
None
0.80A 4kf9A-3bleA:
undetectable
4kf9A-3bleA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmb ACETOACETATE
DECARBOXYLASE


(Methanoculleus
marisnigri)
PF06314
(ADC)
3 GLU A  54
ARG A  88
HIS A  90
None
0.81A 4kf9A-3cmbA:
undetectable
4kf9A-3cmbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1


(Saccharomyces
cerevisiae)
PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB)
3 GLU A 321
ARG A 305
HIS A 306
None
0.87A 4kf9A-3cmmA:
undetectable
4kf9A-3cmmA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY


(Deinococcus
geothermalis)
PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2)
3 GLU A  23
ARG A 117
HIS A 118
None
0.85A 4kf9A-3e97A:
undetectable
4kf9A-3e97A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egc PUTATIVE RIBOSE
OPERON REPRESSOR


(Burkholderia
thailandensis)
PF00532
(Peripla_BP_1)
3 GLU A 276
ARG A 182
HIS A 184
None
0.86A 4kf9A-3egcA:
undetectable
4kf9A-3egcA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gip N-ACYL-D-GLUTAMATE
DEACYLASE


(Bordetella
bronchiseptica)
PF07969
(Amidohydro_3)
3 GLU A 200
ARG A 150
HIS A 146
None
0.85A 4kf9A-3gipA:
undetectable
4kf9A-3gipA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
CYTOCHROME C1, HEME
PROTEIN


(Gallus gallus)
PF02167
(Cytochrom_C1)
3 GLU D 124
ARG D 191
HIS D  14
None
0.85A 4kf9A-3h1lD:
undetectable
4kf9A-3h1lD:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqg TYPE-2 RESTRICTION
ENZYME ECORII


(Escherichia
coli)
PF09019
(EcoRII-C)
3 GLU A 225
ARG A 222
HIS A 273
None
0.85A 4kf9A-3hqgA:
undetectable
4kf9A-3hqgA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE


(Homo sapiens)
PF00566
(RabGAP-TBC)
3 GLU A 541
ARG A 544
HIS A 633
None
0.75A 4kf9A-3hzjA:
undetectable
4kf9A-3hzjA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ic8 UNCHARACTERIZED
GST-LIKE
PROTEINPROTEIN


(Pseudomonas
syringae group
genomosp. 3)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
3 GLU A  16
ARG A  19
HIS A 220
None
0.33A 4kf9A-3ic8A:
35.1
4kf9A-3ic8A:
46.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzh PROBABLE SUGAR
KINASE


(Clostridium
perfringens)
PF00294
(PfkB)
3 GLU A  50
ARG A  46
HIS A  77
None
0.86A 4kf9A-3kzhA:
undetectable
4kf9A-3kzhA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE


(Streptomyces
coelicolor)
no annotation 3 GLU A 234
ARG A 195
HIS A 200
None
0.83A 4kf9A-3lg5A:
undetectable
4kf9A-3lg5A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lh5 TIGHT JUNCTION
PROTEIN ZO-1


(Homo sapiens)
PF00625
(Guanylate_kin)
PF07653
(SH3_2)
3 GLU A 634
ARG A 522
HIS A 524
None
0.85A 4kf9A-3lh5A:
undetectable
4kf9A-3lh5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus)
PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI)
3 GLU A  17
ARG A 286
HIS A 285
None
0.82A 4kf9A-3m6xA:
undetectable
4kf9A-3m6xA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3t PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE


(Thiobacillus
denitrificans)
PF00563
(EAL)
3 GLU A 614
ARG A 642
HIS A 664
None
0.66A 4kf9A-3n3tA:
undetectable
4kf9A-3n3tA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq3 IFN-ALPHA/BETA
BINDING PROTEIN C12R


(Ectromelia
virus)
PF00047
(ig)
PF13895
(Ig_2)
3 GLU B   4
ARG B  61
HIS B  60
None
0.56A 4kf9A-3oq3B:
undetectable
4kf9A-3oq3B:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME


(Homo sapiens;
Escherichia
virus T4)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
3 GLU A 107
ARG A 175
HIS A 172
None
0.87A 4kf9A-3pdsA:
undetectable
4kf9A-3pdsA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qb5 TRANSLIN-ASSOCIATED
PROTEIN X


(Homo sapiens)
PF01997
(Translin)
3 GLU K 197
ARG K 200
HIS K  75
MN  K 291 (-3.3A)
SO4  K 293 (-3.4A)
None
0.81A 4kf9A-3qb5K:
undetectable
4kf9A-3qb5K:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rob UNCHARACTERIZED
CONSERVED PROTEIN


(Planctopirus
limnophila)
PF14534
(DUF4440)
3 GLU A  78
ARG A  90
HIS A 111
None
0.74A 4kf9A-3robA:
undetectable
4kf9A-3robA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7x MAJOR CAPSID PROTEIN
VP1


(Human
polyomavirus 4)
PF00718
(Polyoma_coat)
3 GLU A 123
ARG A 286
HIS A 288
None
0.83A 4kf9A-3s7xA:
undetectable
4kf9A-3s7xA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shw TIGHT JUNCTION
PROTEIN ZO-1


(Homo sapiens)
PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2)
3 GLU A 634
ARG A 522
HIS A 524
None
0.87A 4kf9A-3shwA:
undetectable
4kf9A-3shwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3a KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY B MEMBER
1A


(Mus musculus)
PF00059
(Lectin_C)
3 GLU A 136
ARG A 102
HIS A 101
None
0.78A 4kf9A-3t3aA:
undetectable
4kf9A-3t3aA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsw TIGHT JUNCTION
PROTEIN ZO-1


(Homo sapiens)
PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2)
3 GLU A 634
ARG A 522
HIS A 524
None
0.86A 4kf9A-3tswA:
undetectable
4kf9A-3tswA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE


(Salmonella
enterica)
PF02769
(AIRS_C)
PF13507
(GATase_5)
3 GLU A 483
ARG A1046
HIS A1053
None
0.63A 4kf9A-3ummA:
undetectable
4kf9A-3ummA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
3 GLU A1507
ARG A1467
HIS A1468
None
0.86A 4kf9A-3va7A:
undetectable
4kf9A-3va7A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE


(Helicobacter
pylori)
PF03796
(DnaB_C)
3 GLU A 437
ARG A 456
HIS A 472
None
0.85A 4kf9A-4a1fA:
undetectable
4kf9A-4a1fA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2n 70 KDA PROTEIN

(Xanthomonas sp.
35Y)
no annotation 3 GLU A 337
ARG A  84
HIS A  71
None
0.79A 4kf9A-4b2nA:
undetectable
4kf9A-4b2nA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE


(Trypanosoma
cruzi)
PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8)
3 GLU A 352
ARG A 390
HIS A 360
None
None
SO4  A 505 (-3.9A)
0.62A 4kf9A-4dshA:
undetectable
4kf9A-4dshA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE


(Mycobacterium
avium)
PF04909
(Amidohydro_2)
3 GLU A 151
ARG A  24
HIS A  25
None
0.84A 4kf9A-4dziA:
undetectable
4kf9A-4dziA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL


(Homo sapiens)
PF05292
(MCD)
PF17408
(MCD_N)
3 GLU A 216
ARG A 230
HIS A 254
None
0.80A 4kf9A-4f0xA:
1.6
4kf9A-4f0xA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL


(Homo sapiens)
PF02146
(SIR2)
3 GLU A 238
ARG A 134
HIS A  52
None
0.86A 4kf9A-4g1cA:
undetectable
4kf9A-4g1cA:
23.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN


(Ralstonia
solanacearum)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
3 GLU A  18
ARG A  21
HIS A 224
ZN  A 401 ( 1.9A)
ACT  A 407 (-3.6A)
ZN  A 401 ( 3.2A)
0.00A 4kf9A-4kf9A:
55.5
4kf9A-4kf9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum)
PF11894
(Nup192)
3 GLU A 161
ARG A 252
HIS A 254
None
0.69A 4kf9A-4knhA:
1.1
4kf9A-4knhA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE


(Acinetobacter
baumannii)
PF00348
(polyprenyl_synt)
3 GLU A 180
ARG A 177
HIS A 172
GOL  A 401 (-2.7A)
None
GOL  A 401 (-3.7A)
0.69A 4kf9A-4lobA:
undetectable
4kf9A-4lobA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml9 UNCHARACTERIZED
PROTEIN


(Sebaldella
termitidis)
PF00977
(His_biosynth)
3 GLU A 114
ARG A  79
HIS A  57
None
0.79A 4kf9A-4ml9A:
undetectable
4kf9A-4ml9A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1


(Homo sapiens)
PF00566
(RabGAP-TBC)
3 GLU A 569
ARG A 572
HIS A 661
None
0.68A 4kf9A-4nc6A:
undetectable
4kf9A-4nc6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pch VP1

(Human
polyomavirus 7)
PF00718
(Polyoma_coat)
3 GLU A 104
ARG A 278
HIS A 280
None
0.80A 4kf9A-4pchA:
undetectable
4kf9A-4pchA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE


(Homo sapiens;
Pyrococcus
abyssi)
PF00001
(7tm_1)
PF00534
(Glycos_transf_1)
3 GLU A 212
ARG A 328
HIS A 224
SUV  A2001 (-4.1A)
None
SUV  A2001 ( 4.8A)
0.76A 4kf9A-4s0vA:
undetectable
4kf9A-4s0vA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu2 FERULIC ACID
DECARBOXYLASE


(Enterobacter
sp.)
PF05870
(PA_decarbox)
3 GLU A  28
ARG A  40
HIS A  42
None
0.86A 4kf9A-4uu2A:
undetectable
4kf9A-4uu2A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE


(Pseudomonas sp.
ADP)
PF01979
(Amidohydro_1)
3 GLU A 263
ARG A 290
HIS A 291
None
0.75A 4kf9A-4v1yA:
undetectable
4kf9A-4v1yA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE


(Homo sapiens;
Pyrococcus
abyssi)
PF00001
(7tm_1)
PF00534
(Glycos_transf_1)
3 GLU A 204
ARG A 322
HIS A 216
SUV  A2001 (-4.4A)
None
SUV  A2001 ( 4.8A)
0.82A 4kf9A-4zj8A:
undetectable
4kf9A-4zj8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3


(Pseudomonas
aeruginosa)
PF01471
(PG_binding_1)
PF13406
(SLT_2)
3 GLU A 401
ARG A 376
HIS A 378
None
0.69A 4kf9A-5ao8A:
undetectable
4kf9A-5ao8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT


(Escherichia
coli)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
3 GLU C 462
ARG C 450
HIS C 452
None
0.78A 4kf9A-5g5gC:
undetectable
4kf9A-5g5gC:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE


(Mycobacterium
tuberculosis)
PF02358
(Trehalose_PPase)
3 GLU A 237
ARG A 282
HIS A 283
None
0.81A 4kf9A-5gvxA:
undetectable
4kf9A-5gvxA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN


(Chaetomium
thermophilum)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
3 GLU A 554
ARG A 545
HIS A 540
None
0.78A 4kf9A-5hy7A:
undetectable
4kf9A-5hy7A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium)
PF00264
(Tyrosinase)
3 GLU A 289
ARG A 280
HIS A 279
None
0.82A 4kf9A-5i3aA:
undetectable
4kf9A-5i3aA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE


(Shewanella
denitrificans)
no annotation 3 GLU A 431
ARG A 177
HIS A 128
None
0.86A 4kf9A-5i5jA:
undetectable
4kf9A-5i5jA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE


(Human
picobirnavirus)
no annotation 3 GLU B 341
ARG B 379
HIS B 380
None
0.61A 4kf9A-5i61B:
undetectable
4kf9A-5i61B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kr6 4-AMINOBUTYRATE
TRANSAMINASE


(Pseudomonas)
PF00202
(Aminotran_3)
3 GLU A 386
ARG A 190
HIS A 187
None
0.75A 4kf9A-5kr6A:
undetectable
4kf9A-5kr6A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7s SECRETED RXLR
EFFECTOR PEPTIDE
PROTEIN


(Phytophthora
infestans)
no annotation 3 GLU A 315
ARG A 279
HIS A 276
None
0.85A 4kf9A-5l7sA:
undetectable
4kf9A-5l7sA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lon KLLA0E01827P

(Kluyveromyces
lactis)
PF06058
(DCP1)
3 GLU B   7
ARG B  10
HIS B  31
None
0.85A 4kf9A-5lonB:
undetectable
4kf9A-5lonB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb4 GLCNAC SPECIFIC
LECTIN


(Psathyrella)
PF13517
(VCBS)
3 GLU A 191
ARG A 170
HIS A 171
None
MLI  A 507 (-3.8A)
NDG  A 509 ( 3.9A)
0.85A 4kf9A-5mb4A:
undetectable
4kf9A-5mb4A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN


(Bacteroides
thetaiotaomicron)
PF17132
(Glyco_hydro_106)
3 GLU A 239
ARG A 326
HIS A 328
None
0.82A 4kf9A-5mqmA:
undetectable
4kf9A-5mqmA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT


(Homo sapiens)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
3 GLU A 440
ARG A 497
HIS A 498
None
0.72A 4kf9A-5tusA:
undetectable
4kf9A-5tusA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens)
PF00117
(GATase)
PF06418
(CTP_synth_N)
3 GLU A 510
ARG A 449
HIS A 480
None
0.70A 4kf9A-5u03A:
undetectable
4kf9A-5u03A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1


(Neurospora
crassa)
PF03055
(RPE65)
3 GLU A 213
ARG A 134
HIS A 277
None
0.79A 4kf9A-5u8zA:
undetectable
4kf9A-5u8zA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE


(Streptococcus
mutans)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
3 GLU A 323
ARG A  22
HIS A  26
SO4  A 519 ( 4.8A)
SO4  A 519 ( 3.0A)
None
0.70A 4kf9A-5v36A:
undetectable
4kf9A-5v36A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36


(Bos taurus)
no annotation 3 GLU A 576
ARG A 635
HIS A 578
None
0.82A 4kf9A-5vhaA:
undetectable
4kf9A-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR


(Homo sapiens;
Bos taurus)
PF00010
(HLH)
PF00989
(PAS)
PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11)
3 GLU B 111
ARG A  79
HIS A 156
None
GOL  A 301 ( 4.3A)
None
0.43A 4kf9A-5y7yB:
undetectable
4kf9A-5y7yB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4


(Mus musculus)
no annotation 3 GLU A 138
ARG A 105
HIS A 102
None
0.56A 4kf9A-5z96A:
undetectable
4kf9A-5z96A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4o GLUTATHIONE
REDUCTASE


(Enterococcus
faecalis)
no annotation 3 GLU A 322
ARG A  21
HIS A  25
None
0.73A 4kf9A-6b4oA:
undetectable
4kf9A-6b4oA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE


(Marinobacter
hydrocarbonoclasticus)
no annotation 3 GLU A 116
ARG A  83
HIS A 118
CL  A 502 (-3.8A)
CL  A 501 ( 4.7A)
None
0.73A 4kf9A-6chjA:
undetectable
4kf9A-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1


(Mus musculus)
no annotation 3 GLU A 198
ARG A 468
HIS A 467
None
0.73A 4kf9A-6enzA:
undetectable
4kf9A-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM


(Streptomyces
maritimus)
no annotation 3 GLU A 393
ARG A 396
HIS A 397
None
0.81A 4kf9A-6fydA:
undetectable
4kf9A-6fydA:
undetectable