SIMILAR PATTERNS OF AMINO ACIDS FOR 4KF9_A_ACTA406

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN

(Ralstonia
solanacearum) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 TYR A  11
PHE A 105
ARG A 137
MET A 140
 ACT  A 408 ( 4.8A)
ACT  A 406 ( 4.9A)
GSH  A 405 (-3.5A)
GSH  A 405 ( 3.4A)
 0.00A 4kf9A-4kf9A:
55.5		 4kf9A-4kf9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Saccharomyces
cerevisiae) 		PF12569
(NARP1) 		4 TYR A 819
PHE A 765
ARG A 723
MET A 692
 None
 1.48A 4kf9A-4xpdA:
0.1		 4kf9A-4xpdA:
16.63