SIMILAR PATTERNS OF AMINO ACIDS FOR 4KCN_B_MTLB806_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 SER A 488
ASN A 457
PHE A 460
ASN A 483
 None
 1.36A 4kcnB-1bf2A:
0.0		 4kcnB-1bf2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehx SCAFFOLDIN PROTEIN

([Clostridium]
cellulolyticum) 		PF03442
(CBM_X2) 		4 ASN A  78
GLN A   2
PHE A  72
ASN A  33
 None
 1.11A 4kcnB-1ehxA:
undetectable		 4kcnB-1ehxA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		4 SER 3  94
GLN 3  87
PHE 3  86
ASN 3  97
 None
 1.21A 4kcnB-1ev13:
undetectable		 4kcnB-1ev13:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iw8 ACID PHOSPHATASE

(Shimwellia
blattae) 		PF01569
(PAP2) 		4 ASN A 211
GLN A 216
PHE A 214
ASN A 101
 None
 1.29A 4kcnB-1iw8A:
0.0		 4kcnB-1iw8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5c ENDOPOLYGALACTURONAS
E

(Chondrostereum
purpureum) 		PF00295
(Glyco_hydro_28) 		4 SER A 198
ASN A 179
GLN A 120
ASP A 173
 None
 1.30A 4kcnB-1k5cA:
0.0		 4kcnB-1k5cA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 SER A 208
ASN A 241
GLN A 242
ASN A 216
 None
None
None
FAD  A 800 (-4.1A)
 1.37A 4kcnB-1knrA:
0.0		 4kcnB-1knrA:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		7 SER A 477
ASN A 498
GLN A 500
PHE A 501
ASN A 569
ASP A 709
TRP A 711
 None
 0.28A 4kcnB-1lzxA:
62.2		 4kcnB-1lzxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 SER A 246
ASN A 267
ASN A 338
ASP A 478
TRP A 480
 None
 0.46A 4kcnB-1m9qA:
59.1		 4kcnB-1m9qA:
64.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1u FIBROBLAST GROWTH
FACTOR HOMOLOGOUS
FACTOR 1

(Homo sapiens) 		PF00167
(FGF) 		4 GLN A  24
PHE A  22
ASN A  38
ASP A  36
 None
 1.41A 4kcnB-1q1uA:
0.0		 4kcnB-1q1uA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgi PROTEIN
(CHITOSANASE)

(Bacillus
circulans) 		PF01374
(Glyco_hydro_46) 		4 ASN A 224
GLN A 231
ASN A 176
ASP A 172
 None
 1.41A 4kcnB-1qgiA:
undetectable		 4kcnB-1qgiA:
19.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 SER A 256
PHE A 280
ASN A 348
TRP A 490
 None
 0.50A 4kcnB-1qw5A:
57.9		 4kcnB-1qw5A:
63.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 SER A 517
ASN A 373
GLN A 716
ASN A 521
 None
 1.28A 4kcnB-1rrhA:
undetectable		 4kcnB-1rrhA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twb STRINGENT STARVATION
PROTEIN B HOMOLOG

(Haemophilus
influenzae) 		PF04386
(SspB) 		4 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.04A 4kcnB-1twbA:
undetectable		 4kcnB-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.12A 4kcnB-1uwyA:
undetectable		 4kcnB-1uwyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtm COAT PROTEIN

(Tobacco mild
green mosaic
virus) 		PF00721
(TMV_coat) 		4 SER P  86
GLN P  38
ASN P  85
ASP P  88
 None
 1.42A 4kcnB-1vtmP:
undetectable		 4kcnB-1vtmP:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		4 SER A 297
ASN A 361
PHE A 268
ASP A 266
 None
 1.31A 4kcnB-1xr4A:
undetectable		 4kcnB-1xr4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		4 SER A 379
ASN A 514
GLN A 512
PHE A 511
 None
 1.36A 4kcnB-1ytmA:
undetectable		 4kcnB-1ytmA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		4 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.33A 4kcnB-1yvlA:
undetectable		 4kcnB-1yvlA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		4 SER A 321
GLN A 329
PHE A 326
ASN A 320
 None
 1.09A 4kcnB-1z3vA:
undetectable		 4kcnB-1z3vA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		4 SER A 562
PHE A 563
ASN A 565
ASP A 568
 None
 1.40A 4kcnB-2a3lA:
0.0		 4kcnB-2a3lA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		4 ASN A 128
GLN A 165
ASN A  54
ASP A 131
 None
 1.27A 4kcnB-2a9vA:
undetectable		 4kcnB-2a9vA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE

(Plasmodium
yoelii) 		PF00215
(OMPdecase) 		4 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.35A 4kcnB-2aqwA:
undetectable		 4kcnB-2aqwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckr ENDOGLUCANASE E-5

(Thermobifida
fusca) 		PF00150
(Cellulase) 		4 SER A 392
GLN A 402
PHE A 401
ASN A 390
 None
 1.10A 4kcnB-2ckrA:
0.9		 4kcnB-2ckrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		4 ASN A 266
GLN A 290
ASN A  21
ASP A 213
 None
None
TAR  A1001 (-3.9A)
MG  A2001 ( 2.5A)
 1.27A 4kcnB-2dw6A:
undetectable		 4kcnB-2dw6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv0 LYSOZYME C

(Pelodiscus
sinensis) 		PF00062
(Lys) 		4 SER A  62
GLN A  51
ASN A  61
ASP A  50
 None
 1.25A 4kcnB-2gv0A:
undetectable		 4kcnB-2gv0A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 SER A 512
ASN A 368
GLN A 711
ASN A 516
 None
 1.22A 4kcnB-2iujA:
0.6		 4kcnB-2iujA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 SER A 524
ASN A 379
GLN A 723
ASN A 528
 None
 1.20A 4kcnB-2iukA:
undetectable		 4kcnB-2iukA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2

(Homo sapiens) 		PF00428
(Ribosomal_60s) 		4 SER B 117
ASN B 147
ASN B 115
ASP B 122
 None
 1.04A 4kcnB-2lbfB:
undetectable		 4kcnB-2lbfB:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llz UNCHARACTERIZED
PROTEIN YJDK

(Escherichia
coli) 		PF11080
(GhoS) 		4 ASN A  55
PHE A  16
ASN A  87
ASP A  85
 None
 1.43A 4kcnB-2llzA:
undetectable		 4kcnB-2llzA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyz HYPOTHETICAL PROTEIN
GAMMAHV.M3

(Murid
gammaherpesvirus
4) 		PF09213
(M3) 		4 SER A 113
GLN A 176
PHE A 173
TRP A  76
 None
 1.24A 4kcnB-2nyzA:
undetectable		 4kcnB-2nyzA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1

(Streptococcus
agalactiae) 		PF13672
(PP2C_2) 		4 SER A 134
ASN A 140
GLN A 164
ASP A 175
 None
 1.31A 4kcnB-2pk0A:
undetectable		 4kcnB-2pk0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4g TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		4 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.29A 4kcnB-2r4gA:
undetectable		 4kcnB-2r4gA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ASN A 391
GLN A 389
PHE A 388
ASN A 491
 None
 1.13A 4kcnB-2w40A:
undetectable		 4kcnB-2w40A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqq ALPHA-2,3-/2,8-SIALY
LTRANSFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		4 ASN A 116
GLN A 111
ASN A  80
ASP A 107
 None
 1.37A 4kcnB-2wqqA:
undetectable		 4kcnB-2wqqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		4 ASN A 116
GLN A 111
ASN A  80
ASP A 107
 None
 1.33A 4kcnB-2x63A:
undetectable		 4kcnB-2x63A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER

(Escherichia
coli) 		PF03797
(Autotransporter) 		4 ASN A1372
GLN A1141
ASN A1101
ASP A1100
 None
 1.43A 4kcnB-3aehA:
undetectable		 4kcnB-3aehA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae) 		PF00923
(TAL_FSA) 		4 ASN A  43
GLN A  48
PHE A  47
ASN A  18
 CL  A 352 ( 4.4A)
None
None
None
 1.41A 4kcnB-3clmA:
1.5		 4kcnB-3clmA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans;
Candida
albicans) 		PF01239
(PPTA)
PF00432
(Prenyltrans) 		4 SER A 221
ASN B 290
GLN A 218
ASN A 224
 None
 1.43A 4kcnB-3draA:
undetectable		 4kcnB-3draA:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 1.05A 4kcnB-3e7gA:
57.5		 4kcnB-3e7gA:
65.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1r FIBROBLAST GROWTH
FACTOR 20

(Homo sapiens) 		PF00167
(FGF) 		4 SER A 115
GLN A  86
PHE A  95
ASP A  82
 None
 1.43A 4kcnB-3f1rA:
undetectable		 4kcnB-3f1rA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.12A 4kcnB-3ihvA:
undetectable		 4kcnB-3ihvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		4 ASN A 281
GLN A 274
ASN A  53
ASP A  51
 None
 1.35A 4kcnB-3ij6A:
undetectable		 4kcnB-3ij6A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqx TAIL-ANCHORED
PROTEIN TARGETING
FACTOR GET3

(Chaetomium
thermophilum) 		PF02374
(ArsA_ATPase) 		4 ASN A 225
GLN A 227
PHE A 228
TRP A  29
 None
 1.40A 4kcnB-3iqxA:
undetectable		 4kcnB-3iqxA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ita D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 SER A  83
PHE A  86
ASN A 108
ASP A 109
 None
 1.35A 4kcnB-3itaA:
undetectable		 4kcnB-3itaA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		4 SER A 109
ASN A 289
PHE A 294
TRP A 239
 None
 1.21A 4kcnB-3ix1A:
undetectable		 4kcnB-3ix1A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrv PRE-MRNA-SPLICING
FACTOR 19

(Saccharomyces
cerevisiae) 		no annotation 4 ASN A 497
PHE A 496
ASN A 187
ASP A 494
 None
None
SO4  A  69 (-4.3A)
None
 1.32A 4kcnB-3lrvA:
undetectable		 4kcnB-3lrvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0l STEROIDOGENIC ACUTE
REGULATORY PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF01852
(START) 		4 ASN A 150
GLN A 264
PHE A 267
ASN A 269
 None
 1.42A 4kcnB-3p0lA:
undetectable		 4kcnB-3p0lA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbg PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF12134
(PRP8_domainIV) 		4 SER A2197
ASN A2159
PHE A2382
TRP A2357
 None
 1.43A 4kcnB-3sbgA:
undetectable		 4kcnB-3sbgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sok FIMBRIAL PROTEIN

(Dichelobacter
nodosus) 		PF00114
(Pilin)
PF07963
(N_methyl) 		4 SER A 130
ASN A 151
ASN A 128
ASP A  92
 None
 1.35A 4kcnB-3sokA:
undetectable		 4kcnB-3sokA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 ASN A 175
GLN A 171
PHE A 170
ASN A 303
 None
 1.14A 4kcnB-3to3A:
undetectable		 4kcnB-3to3A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uau SURFACE-EXPOSED
LIPOPROTEIN

(Campylobacter
jejuni) 		PF16668
(JLPA) 		4 SER A 175
ASN A 177
GLN A 123
ASN A 174
 None
 1.34A 4kcnB-3uauA:
undetectable		 4kcnB-3uauA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp2 EPITHELIAL ADHESIN 9

([Candida]
glabrata) 		PF10528
(GLEYA) 		4 SER A 171
PHE A 147
ASN A 172
ASP A 258
 None
None
None
GAL  A1296 ( 3.5A)
 1.32A 4kcnB-4cp2A:
undetectable		 4kcnB-4cp2A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE

(Clostridioides
difficile) 		PF00155
(Aminotran_1_2) 		4 SER A 356
ASN A 352
ASN A 355
TRP A 326
 None
 1.30A 4kcnB-4dq6A:
undetectable		 4kcnB-4dq6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 340
PHE A 322
ASN A 339
TRP A 303
 None
 1.43A 4kcnB-4ewjA:
undetectable		 4kcnB-4ewjA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ASN B 912
GLN B 980
PHE B 979
ASP B 973
 None
 1.07A 4kcnB-4f92B:
1.0		 4kcnB-4f92B:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 ASN A 406
GLN A 371
PHE A 369
ASN A 434
 ASN  A 406 ( 0.6A)
GLN  A 371 ( 0.6A)
PHE  A 369 ( 1.3A)
ASN  A 434 ( 0.6A)
 1.36A 4kcnB-4g9kA:
undetectable		 4kcnB-4g9kA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		4 SER B  62
GLN B  86
ASN B  43
ASP B  60
 None
 1.26A 4kcnB-4hxeB:
undetectable		 4kcnB-4hxeB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irx SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caulobacter
vibrioides) 		PF13407
(Peripla_BP_4) 		4 ASN A 231
GLN A 278
ASN A  45
ASP A 125
 INS  A 401 (-3.9A)
INS  A 401 (-3.1A)
None
INS  A 401 (-2.8A)
 1.25A 4kcnB-4irxA:
undetectable		 4kcnB-4irxA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llr TRYPAREDOXIN
PEROXIDASE

(Trypanosoma
cruzi) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 PHE A 163
ASN A 138
ASP A 134
TRP A  38
 None
 1.44A 4kcnB-4llrA:
undetectable		 4kcnB-4llrA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m00 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		4 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
SUC  A 804 (-3.3A)
 1.26A 4kcnB-4m00A:
undetectable		 4kcnB-4m00A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m01 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		no annotation 4 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.25A 4kcnB-4m01A:
undetectable		 4kcnB-4m01A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oi3 NICKEL RESPONSIVE
PROTEIN

(Streptomyces
coelicolor) 		PF14026
(DUF4242) 		4 SER A  53
GLN A  62
PHE A   4
ASP A   6
 None
 1.33A 4kcnB-4oi3A:
undetectable		 4kcnB-4oi3A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus) 		PF03664
(Glyco_hydro_62) 		4 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.32A 4kcnB-4pviA:
undetectable		 4kcnB-4pviA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3f SPLICEOSOMAL PROTEIN
CWC27

(Chaetomium
thermophilum) 		PF00160
(Pro_isomerase) 		4 SER A  77
ASN A 107
PHE A 108
TRP A  91
 None
 1.39A 4kcnB-4r3fA:
undetectable		 4kcnB-4r3fA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		4 GLN C 757
PHE C 776
ASN C 770
ASP C 771
 None
 1.42A 4kcnB-4u1cC:
undetectable		 4kcnB-4u1cC:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uac CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-)

([Eubacterium]
rectale) 		PF13416
(SBP_bac_8) 		4 GLN A 394
PHE A 189
ASN A 191
ASP A 190
 EDO  A 504 (-3.3A)
None
ACR  A 501 (-3.3A)
EDO  A 504 ( 4.2A)
 1.19A 4kcnB-4uacA:
undetectable		 4kcnB-4uacA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3C

(Lachancea
kluyveri) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		4 GLN c 757
PHE c 776
ASN c 770
ASP c 771
 None
 1.43A 4kcnB-4uerc:
undetectable		 4kcnB-4uerc:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh3 N-ACETYLHEXOSAMINE
1-KINASE

(Bifidobacterium
longum) 		PF01636
(APH) 		4 SER A 244
GLN A 131
PHE A 241
ASP A 240
 None
 1.43A 4kcnB-4wh3A:
undetectable		 4kcnB-4wh3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ym3 GALECTIN-4

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 SER A 220
ASN A 238
GLN A 313
PHE A 221
 None
LAT  A 401 (-4.0A)
None
None
 1.44A 4kcnB-4ym3A:
undetectable		 4kcnB-4ym3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.26A 4kcnB-4yzzA:
undetectable		 4kcnB-4yzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9p NUCLEOPROTEIN

(Zaire
ebolavirus) 		PF05505
(Ebola_NP) 		4 SER A 279
GLN A 315
PHE A 313
ASN A 278
 None
 1.37A 4kcnB-4z9pA:
undetectable		 4kcnB-4z9pA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4

(Saccharomyces
cerevisiae) 		PF01793
(Glyco_transf_15) 		4 PHE A 241
ASN A 172
ASP A 173
TRP A 204
 None
 1.34A 4kcnB-5a08A:
undetectable		 4kcnB-5a08A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLN A 263
PHE A 223
ASN A 182
ASP A 214
 None
 1.45A 4kcnB-5aa5A:
undetectable		 4kcnB-5aa5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		4 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.12A 4kcnB-5aexA:
undetectable		 4kcnB-5aexA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnz GLUTAMINE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 GLN A 202
PHE A  67
ASN A  38
ASP A  76
 None
 1.18A 4kcnB-5bnzA:
undetectable		 4kcnB-5bnzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boe ENOLASE

(Staphylococcus
aureus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 339
PHE A 321
ASN A 338
TRP A 302
 None
 1.39A 4kcnB-5boeA:
undetectable		 4kcnB-5boeA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 SER A 202
ASN A 114
PHE A 113
ASN A 201
 None
 1.13A 4kcnB-5dkuA:
undetectable		 4kcnB-5dkuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du3 PLASMA PROTEASE C1
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 SER A 198
ASN A 269
GLN A 201
TRP A 243
 None
 1.31A 4kcnB-5du3A:
undetectable		 4kcnB-5du3A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 4 ASN A 434
GLN A 382
PHE A 436
ASP A 314
 None
None
None
CU  A 601 (-2.0A)
 1.38A 4kcnB-5f75A:
undetectable		 4kcnB-5f75A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fws KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		4 SER A  92
ASN A 187
ASN A  86
TRP A 106
 None
 1.41A 4kcnB-5fwsA:
undetectable		 4kcnB-5fwsA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 SER A 709
GLN A 625
PHE A 629
ASN A 708
 None
GOL  A 824 (-4.4A)
None
GLC  A 815 ( 4.1A)
 1.32A 4kcnB-5gr1A:
undetectable		 4kcnB-5gr1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 317
GLN A 352
ASN A 291
TRP A 353
 None
None
NAG  A 810 (-2.7A)
None
 1.14A 4kcnB-5gs0A:
undetectable		 4kcnB-5gs0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 GLN A 583
PHE A 594
ASN A 488
ASP A 604
 None
 1.36A 4kcnB-5i4eA:
undetectable		 4kcnB-5i4eA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 SER A 663
GLN B1065
PHE B1086
ASN A 742
 None
 1.34A 4kcnB-5ip9A:
undetectable		 4kcnB-5ip9A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus sp.
GHH01) 		PF00793
(DAHP_synth_1)
PF01817
(CM_2) 		4 SER A 332
GLN A 164
PHE A 163
ASP A 162
 None
None
None
SO4  A 402 ( 4.9A)
 1.40A 4kcnB-5j6fA:
undetectable		 4kcnB-5j6fA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm0 ALPHA-MANNOSIDASE,AL
PHA-MANNOSIDASE,ALPH
A-MANNOSIDASE

(Saccharomyces
cerevisiae) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 GLN A 130
PHE A 198
ASN A 195
ASP A 132
 None
 1.40A 4kcnB-5jm0A:
undetectable		 4kcnB-5jm0A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 GLN A 346
PHE A 347
ASN A 303
ASP A 349
 None
 1.37A 4kcnB-5kzsA:
undetectable		 4kcnB-5kzsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lii MAJOR CAPSID PROTEIN

(Staphylococcus
phage 812) 		no annotation 4 ASN P 247
GLN P 237
ASN P 242
ASP P 241
 None
 1.27A 4kcnB-5liiP:
undetectable		 4kcnB-5liiP:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1q N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
DOMAIN-CONTAINING
PROTEIN
SAOUHSC_02979

(Staphylococcus
aureus) 		PF01832
(Glucosaminidase)
PF05257
(CHAP) 		4 ASN A 283
PHE A 282
ASN A 383
ASP A 290
 None
 1.14A 4kcnB-5t1qA:
undetectable		 4kcnB-5t1qA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpw GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 SER B 118
GLN B 111
PHE B 115
ASP B 114
 None
 1.38A 4kcnB-5tpwB:
undetectable		 4kcnB-5tpwB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr0 SEED LINOLEATE
13S-LIPOXYGENASE-1

(Glycine max) 		no annotation 4 SER A 498
ASN A 355
GLN A 697
ASN A 502
 None
 1.25A 4kcnB-5tr0A:
undetectable		 4kcnB-5tr0A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)

(Neisseria
meningitidis;
Neisseria
meningitidis) 		PF13395
(HNH_4)
no annotation 		4 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.19A 4kcnB-5vgbA:
undetectable		 4kcnB-5vgbA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.19A 4kcnB-5w3fA:
undetectable		 4kcnB-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wql TAIL-SPECIFIC
PROTEASE

(Escherichia
coli) 		no annotation 4 SER C 503
ASN C 238
GLN C 236
PHE C 237
 None
 1.18A 4kcnB-5wqlC:
undetectable		 4kcnB-5wqlC:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xg8 GALACTOSIDE-BINDING
SOLUBLE LECTIN 13

(Homo sapiens) 		no annotation 4 SER A  29
PHE A  30
ASN A  32
ASP A  33
 None
 1.32A 4kcnB-5xg8A:
undetectable		 4kcnB-5xg8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii;
Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 SER A 664
GLN B1065
PHE B1086
ASN A 743
 None
 1.31A 4kcnB-5xogA:
undetectable		 4kcnB-5xogA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		no annotation 4 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.22A 4kcnB-5yh5A:
undetectable		 4kcnB-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE

(Bacillus
licheniformis) 		no annotation 4 SER A 120
ASN A 127
GLN A 125
PHE A 126
 None
 1.25A 4kcnB-6b7kA:
undetectable		 4kcnB-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3i -

(-) 		no annotation 4 GLN A  53
PHE A 140
ASN A 265
ASP A 264
 None
 1.40A 4kcnB-6d3iA:
undetectable		 4kcnB-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 SER A 507
ASN A 581
ASN A 508
ASP A 467
 None
 1.30A 4kcnB-6fikA:
undetectable		 4kcnB-6fikA:
undetectable