SIMILAR PATTERNS OF AMINO ACIDS FOR 4KCN_B_MTLB805

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fob BETA-1,4-GALACTANASE

(Aspergillus
aculeatus) 		PF07745
(Glyco_hydro_53) 		4 ARG A  47
ASP A  79
ASP A   8
ARG A  45
 None
 1.39A 4kcnB-1fobA:
0.2		 4kcnB-1fobA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 ARG A 161
ASP A 176
ASP A 163
ARG A 178
 None
 1.33A 4kcnB-1g68A:
undetectable		 4kcnB-1g68A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5y HISF

(Pyrobaculum
aerophilum) 		PF00977
(His_biosynth) 		4 GLU A 188
ASP A 186
ASP A 177
ARG A 178
 None
 1.22A 4kcnB-1h5yA:
undetectable		 4kcnB-1h5yA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7k CATALASE

(Proteus
mirabilis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLU A 416
ARG A 413
ASP A 415
ARG A 135
 None
 1.37A 4kcnB-1h7kA:
undetectable		 4kcnB-1h7kA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		4 ARG A  47
ASP A  79
ASP A   8
ARG A  45
 None
None
None
TRS  A 704 ( 4.1A)
 1.40A 4kcnB-1hjuA:
undetectable		 4kcnB-1hjuA:
23.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		6 ARG A 481
GLU A 592
ARG A 596
ASP A 597
ASP A 600
ARG A 603
 None
HAR  A 770 ( 2.9A)
H4B  A 760 (-3.5A)
HAR  A 770 (-2.8A)
None
None
 0.32A 4kcnB-1lzxA:
62.2		 4kcnB-1lzxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 ARG A 250
ARG A 365
ASP A 369
ARG A 372
 None
MPD  A 605 ( 4.7A)
None
None
 0.42A 4kcnB-1m9qA:
59.1		 4kcnB-1m9qA:
64.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG

(Staphylococcus
aureus) 		PF02898
(NO_synthase) 		5 ARG A 124
GLU A 230
ARG A 234
ASP A 238
ARG A 241
 None
ITU  A 800 ( 3.0A)
NAD  A 700 (-3.2A)
None
None
 0.63A 4kcnB-1mjtA:
45.0		 4kcnB-1mjtA:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		4 ARG A 161
ASP A 176
ASP A 163
ARG A 178
 None
 1.38A 4kcnB-1n9bA:
undetectable		 4kcnB-1n9bA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 ARG A 111
ASP A 103
ASP A 105
ARG A 106
 None
 1.25A 4kcnB-1qhgA:
undetectable		 4kcnB-1qhgA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase) 		4 ARG A 111
ASP A 103
ASP A 105
ARG A 106
 None
 1.21A 4kcnB-1qhhA:
undetectable		 4kcnB-1qhhA:
17.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		6 ARG A 260
GLU A 371
ARG A 375
ASP A 376
ASP A 379
ARG A 382
 None
14W  A 902 ( 3.2A)
H4B  A 901 (-3.4A)
None
None
None
 0.45A 4kcnB-1qw5A:
57.9		 4kcnB-1qw5A:
63.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7h ORNITHINE
CYCLODEAMINASE

(Pseudomonas
putida) 		PF02423
(OCD_Mu_crystall) 		4 ARG A 305
ASP A  62
ASP A  33
ARG A  36
 None
 0.93A 4kcnB-1u7hA:
undetectable		 4kcnB-1u7hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcn CTP SYNTHETASE

(Thermus
thermophilus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 ARG A 468
ASP A  92
ASP A  90
ARG A 528
 None
 1.38A 4kcnB-1vcnA:
undetectable		 4kcnB-1vcnA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLU A 620
ARG A 622
ASP A 651
ARG A 648
 None
 1.13A 4kcnB-1z1wA:
undetectable		 4kcnB-1z1wA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		4 ARG A 161
ASP A 176
ASP A 163
ARG A 178
 None
 1.33A 4kcnB-1zg4A:
undetectable		 4kcnB-1zg4A:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS

(Bacillus
subtilis) 		PF02898
(NO_synthase) 		5 ARG A 128
GLU A 239
ARG A 243
ASP A 247
ARG A 250
 ARG  A2000 (-4.0A)
ARG  A2000 ( 3.1A)
H4B  A 903 (-3.4A)
None
None
 0.55A 4kcnB-2an2A:
48.5		 4kcnB-2an2A:
40.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atp T-CELL SURFACE
GLYCOPROTEIN CD8
BETA CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 GLU B  89
ASP B  90
ASP B  92
ARG B  35
 None
 1.28A 4kcnB-2atpB:
undetectable		 4kcnB-2atpB:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		4 GLU A 363
ARG A 359
ASP A 378
ASP A 382
 None
 1.28A 4kcnB-2cjqA:
undetectable		 4kcnB-2cjqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		4 GLU A 100
ARG A 103
ASP A 440
ARG A 437
 None
None
None
NAP  A 476 (-4.5A)
 1.11A 4kcnB-2euhA:
undetectable		 4kcnB-2euhA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f31 DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		4 GLU A 318
ARG A 322
ASP A 320
ASP A 363
 None
 1.25A 4kcnB-2f31A:
undetectable		 4kcnB-2f31A:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2flq NITRIC OXIDE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF02898
(NO_synthase) 		5 ARG A 138
GLU A 248
ARG A 252
ASP A 256
ARG A 259
 ARG  A 376 (-3.6A)
ARG  A 376 ( 2.9A)
None
None
None
 0.70A 4kcnB-2flqA:
47.9		 4kcnB-2flqA:
42.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		4 ARG A 170
ARG A 211
ASP A 336
ASP A 338
 None
 1.38A 4kcnB-2gfiA:
undetectable		 4kcnB-2gfiA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE

(Leptospira
interrogans) 		PF01596
(Methyltransf_3) 		4 GLU A 233
ARG A 231
ASP A 215
ARG A 229
 None
SO4  A1001 (-3.6A)
SO4  A1001 ( 4.8A)
SO4  A1001 (-2.6A)
 1.32A 4kcnB-2hnkA:
1.7		 4kcnB-2hnkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jls SERINE PROTEASE
SUBUNIT NS3

(Dengue virus) 		PF07652
(Flavi_DEAD) 		4 ARG A 217
ARG A 241
ASP A 258
ASP A 250
 None
 1.24A 4kcnB-2jlsA:
undetectable		 4kcnB-2jlsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlv NUCLEAR PROTEIN SNF4

(Saccharomyces
cerevisiae) 		PF00571
(CBS) 		4 ARG C 294
GLU C 269
ARG C 264
ASP C 240
 None
 1.32A 4kcnB-2qlvC:
undetectable		 4kcnB-2qlvC:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qup BH1478 PROTEIN

(Bacillus
halodurans) 		PF03885
(DUF327) 		4 GLU A  89
ARG A  90
ASP A  36
ARG A  35
 None
 1.28A 4kcnB-2qupA:
2.3		 4kcnB-2qupA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 305
ARG A  95
ASP A  25
ASP A  27
 None
 0.98A 4kcnB-2qygA:
undetectable		 4kcnB-2qygA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLU A  69
ARG A  95
ASP A  25
ASP A  27
 None
 1.40A 4kcnB-2qygA:
undetectable		 4kcnB-2qygA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		4 ARG A 433
ARG A 406
ASP A 407
ARG A 410
 SO4  A1465 ( 2.4A)
None
None
SO4  A1465 (-4.6A)
 1.20A 4kcnB-2vgqA:
undetectable		 4kcnB-2vgqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		4 GLU D 957
ARG D 773
ASP D 972
ASP D 977
 None
 1.23A 4kcnB-2vnuD:
undetectable		 4kcnB-2vnuD:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLU A 252
ASP A 191
ASP A 104
ARG A 107
 None
 1.30A 4kcnB-2wgeA:
undetectable		 4kcnB-2wgeA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 ARG A 516
ASP A 675
ASP A 644
ARG A 648
 None
 1.39A 4kcnB-2wghA:
2.6		 4kcnB-2wghA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
RAR1

(Hordeum
vulgare;
Arabidopsis
thaliana) 		PF00183
(HSP90)
PF02518
(HATPase_c)
PF04968
(CHORD) 		4 GLU E 206
ARG E 192
ASP A  45
ARG A  48
 None
 1.31A 4kcnB-2xcmE:
undetectable		 4kcnB-2xcmE:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 ARG A 805
ASP A 840
ASP A 803
ARG A 841
 None
 1.30A 4kcnB-2y3aA:
undetectable		 4kcnB-2y3aA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9p CG5977-PA, ISOFORM A

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 GLU A 705
ARG A 704
ASP A 726
ASP A 697
 None
 1.27A 4kcnB-3b9pA:
undetectable		 4kcnB-3b9pA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfg CLASS A
BETA-LACTAMASE SED1

(Citrobacter
sedlakii) 		PF13354
(Beta-lactamase2) 		4 ARG A 161
ASP A 176
ASP A 163
ARG A 178
 None
 1.40A 4kcnB-3bfgA:
undetectable		 4kcnB-3bfgA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byd BETA-LACTAMASE OXY-1

(Klebsiella
oxytoca) 		PF13354
(Beta-lactamase2) 		4 ARG A 164
ASP A 179
ASP A 166
ARG A 181
 None
None
None
ACT  A 305 (-3.2A)
 1.38A 4kcnB-3bydA:
undetectable		 4kcnB-3bydA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		6 ARG A 266
GLU A 377
ARG A 381
ASP A 382
ASP A 385
ARG A 388
 AT2  A 906 (-3.6A)
AT2  A 906 ( 2.7A)
H4B  A 902 (-3.9A)
AT2  A 906 (-4.4A)
None
AT2  A 906 (-3.1A)
 0.51A 4kcnB-3e7gA:
57.5		 4kcnB-3e7gA:
65.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euj CHROMOSOME PARTITION
PROTEIN MUKB, LINKER

([Haemophilus]
ducreyi) 		PF04310
(MukB)
PF13558
(SbcCD_C) 		4 ARG A1308
GLU A1364
ASP A 248
ARG A 247
 None
 1.34A 4kcnB-3eujA:
undetectable		 4kcnB-3eujA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f75 CATHEPSIN L PROTEASE
CATHEPSIN L
PROPEPTIDE

(Toxoplasma
gondii;
Toxoplasma
gondii) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 ARG P 170
ASP P 171
ASP A 145
ARG P 174
 CL  A 301 (-4.2A)
None
None
None
 0.98A 4kcnB-3f75P:
undetectable		 4kcnB-3f75P:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF09334
(tRNA-synt_1g) 		4 ARG A 403
GLU A 467
ASP A 470
ASP A 472
 None
 1.26A 4kcnB-3h9cA:
undetectable		 4kcnB-3h9cA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 310
ASP A 313
ASP A 332
ARG A 323
 None
 1.40A 4kcnB-3i4gA:
undetectable		 4kcnB-3i4gA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		4 GLU A 354
ARG A 355
ASP A 507
ARG A  52
 None
 1.23A 4kcnB-3ihgA:
undetectable		 4kcnB-3ihgA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ism CG4930

(Drosophila
melanogaster) 		PF08785
(Ku_PK_bind) 		4 GLU C  93
ARG C  96
ASP C 143
ARG C 142
 None
 1.38A 4kcnB-3ismC:
undetectable		 4kcnB-3ismC:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 425
GLU A 402
ASP A  78
ARG A 418
 None
 1.21A 4kcnB-3l22A:
undetectable		 4kcnB-3l22A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m85 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Archaeoglobus
fulgidus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ARG G  33
GLU G 203
ASP G 145
ASP G 144
 None
 1.06A 4kcnB-3m85G:
undetectable		 4kcnB-3m85G:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt1 PUTATIVE
CARBOXYNORSPERMIDINE
DECARBOXYLASE
PROTEIN

(Sinorhizobium
meliloti) 		PF00278
(Orn_DAP_Arg_deC) 		4 ARG A 222
GLU A 182
ASP A 174
ARG A 215
 None
 1.29A 4kcnB-3mt1A:
undetectable		 4kcnB-3mt1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ARG A 304
ARG A 121
ASP A 271
ASP A 273
 None
 1.34A 4kcnB-3nvlA:
undetectable		 4kcnB-3nvlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bacillus
halodurans) 		PF00171
(Aldedh) 		4 GLU A 109
ARG A 112
ASP A 449
ARG A 446
 None
SO4  A 506 (-3.1A)
None
None
 1.29A 4kcnB-3prlA:
undetectable		 4kcnB-3prlA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sorangium
cellulosum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 254
ARG A 258
ASP A 255
ARG A 227
 None
 1.11A 4kcnB-3s5sA:
undetectable		 4kcnB-3s5sA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8m ENOYL-ACP REDUCTASE

(Xanthomonas
oryzae) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 GLU A 326
ARG A 334
ASP A 337
ASP A 336
 None
 1.28A 4kcnB-3s8mA:
undetectable		 4kcnB-3s8mA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA

(Streptomyces
lividans) 		PF00266
(Aminotran_5) 		4 GLU A 221
ARG A 214
ASP A  61
ARG A 236
 None
 1.19A 4kcnB-3vaxA:
undetectable		 4kcnB-3vaxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4q BETA-LACTAMASE

(Burkholderia
multivorans) 		PF13354
(Beta-lactamase2) 		4 ARG A 161
ASP A 176
ASP A 163
ARG A 178
 None
 1.37A 4kcnB-3w4qA:
undetectable		 4kcnB-3w4qA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aod ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 1

(Biomphalaria
glabrata) 		PF02931
(Neur_chan_LBD) 		4 ARG A 123
ASP A  44
ASP A  51
ARG A  42
 None
 1.16A 4kcnB-4aodA:
undetectable		 4kcnB-4aodA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 ARG A 403
ASP A 117
ASP A 391
ARG A 396
 None
None
MG  A1664 (-3.5A)
None
 1.38A 4kcnB-4c30A:
undetectable		 4kcnB-4c30A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6y BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 ARG A 161
ASP A 176
ASP A 163
ARG A 178
 PEG  A 292 ( 4.8A)
None
PEG  A 292 (-3.5A)
None
 1.35A 4kcnB-4c6yA:
undetectable		 4kcnB-4c6yA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c75 BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 ARG A 161
ASP A 176
ASP A 163
ARG A 178
 None
 1.34A 4kcnB-4c75A:
undetectable		 4kcnB-4c75A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq8 ACETATE KINASE

(Mycobacterium
marinum) 		PF00871
(Acetate_kinase) 		4 ARG A 345
ARG A 356
ASP A 343
ASP A 360
 None
 1.38A 4kcnB-4dq8A:
undetectable		 4kcnB-4dq8A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkt INOSITOL
2-DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ARG A 254
GLU A 251
ARG A 238
ASP A 236
 None
 0.95A 4kcnB-4hktA:
undetectable		 4kcnB-4hktA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix9 V-TYPE PROTON ATPASE
SUBUNIT F

(Saccharomyces
cerevisiae) 		PF01990
(ATP-synt_F) 		4 GLU A  60
ARG A  61
ASP A  63
ARG A   5
 None
 1.13A 4kcnB-4ix9A:
undetectable		 4kcnB-4ix9A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ARG A3812
GLU A3818
ARG A3822
ASP A3884
 None
 0.96A 4kcnB-4kc5A:
undetectable		 4kcnB-4kc5A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw8 PUTATIVE EPIMERASE

(Burkholderia
cenocepacia) 		PF01370
(Epimerase) 		4 ARG A  77
ARG A   8
ASP A  36
ARG A  12
 None
 1.23A 4kcnB-4lw8A:
undetectable		 4kcnB-4lw8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG

(Homo sapiens;
Homo sapiens) 		PF08514
(STAG)
no annotation 		4 ARG A 305
GLU A 303
ARG A 213
ASP B 327
 None
 1.23A 4kcnB-4pjuA:
undetectable		 4kcnB-4pjuA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r22 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TNRA

(Bacillus
megaterium) 		PF13411
(MerR_1) 		4 GLU B  57
ASP B  61
ASP B  64
ARG B  65
 None
 1.33A 4kcnB-4r22B:
undetectable		 4kcnB-4r22B:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wa8 FLAP ENDONUCLEASE 1

(Methanopyrus
kandleri) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 GLU A 130
ARG A 134
ASP A 131
ARG A 314
 None
 1.32A 4kcnB-4wa8A:
undetectable		 4kcnB-4wa8A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 ARG A 400
ARG A 250
ASP A 345
ASP A 258
 None
 1.37A 4kcnB-4zzqA:
undetectable		 4kcnB-4zzqA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buk FADH2-DEPENDENT
HALOGENASE

(Streptomyces
sp. CNQ-418) 		PF04820
(Trp_halogenase) 		4 ARG A 289
ARG A 122
ASP A 121
ASP A 126
 None
FAD  A 501 (-3.0A)
None
FAD  A 501 ( 4.8A)
 1.36A 4kcnB-5bukA:
undetectable		 4kcnB-5bukA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ca5 NONO-1

(Caenorhabditis
elegans) 		PF00076
(RRM_1)
PF08075
(NOPS) 		4 ARG A 160
GLU A 168
ASP A 274
ASP A 272
 None
 1.40A 4kcnB-5ca5A:
undetectable		 4kcnB-5ca5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d28 GM-CSF/IL-2
INHIBITION FACTOR

(Orf virus) 		no annotation 4 ARG A  96
ASP A 117
ASP A 114
ARG A  39
 None
 1.39A 4kcnB-5d28A:
undetectable		 4kcnB-5d28A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbj FADH2-DEPENDENT
HALOGENASE PLTA

(Pseudomonas
protegens) 		no annotation 4 ARG E 291
ARG E 123
ASP E 122
ASP E 127
 None
FAD  E 501 (-2.9A)
None
None
 1.36A 4kcnB-5dbjE:
undetectable		 4kcnB-5dbjE:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkd TRANSCRIPTION
ACTIVATOR BRG1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 GLU A1548
ASP A1549
ASP A1474
ARG A1479
 None
 1.13A 4kcnB-5dkdA:
undetectable		 4kcnB-5dkdA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 ARG A 365
GLU A 309
ARG A 324
ASP A 347
 None
 1.14A 4kcnB-5dl6A:
undetectable		 4kcnB-5dl6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 GLU A 309
ARG A 324
ASP A 349
ASP A 347
 None
 1.29A 4kcnB-5dl6A:
undetectable		 4kcnB-5dl6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 ARG A 154
ASP A 169
ASP A 156
ARG A 171
 None
 1.39A 4kcnB-5eoeA:
undetectable		 4kcnB-5eoeA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f83 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 ARG A 156
ASP A 171
ASP A 158
ARG A 173
 None
 1.38A 4kcnB-5f83A:
undetectable		 4kcnB-5f83A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai PEPTIDOGLYCAN
HYDROLASE GP4

(Salmonella
virus P22) 		PF11650
(P22_Tail-4) 		4 GLU K  78
ARG K  20
ASP K  80
ASP K  81
 None
 1.28A 4kcnB-5gaiK:
undetectable		 4kcnB-5gaiK:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl9 BETA-LACTAMASE

(Burkholderia
thailandensis) 		PF13354
(Beta-lactamase2) 		4 ARG A 161
ASP A 176
ASP A 163
ARG A 178
 None
 1.38A 4kcnB-5gl9A:
undetectable		 4kcnB-5gl9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3a ORF70

(Human
gammaherpesvirus
8) 		PF00303
(Thymidylat_synt) 		4 ARG A 123
ASP A 121
ASP A 172
ARG A 151
 None
 1.29A 4kcnB-5h3aA:
undetectable		 4kcnB-5h3aA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx9 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		4 ARG A 161
ASP A 176
ASP A 163
ARG A 178
 None
 1.33A 4kcnB-5hx9A:
undetectable		 4kcnB-5hx9A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig9 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 4 ARG A  31
ASP A  57
ASP A  33
ARG A  36
 None
 1.10A 4kcnB-5ig9A:
undetectable		 4kcnB-5ig9A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihv BETA-LACTAMASE

(Burkholderia
ambifaria) 		PF13354
(Beta-lactamase2) 		4 ARG A 138
ASP A 153
ASP A 140
ARG A 155
 None
None
EDO  A 301 ( 4.5A)
None
 1.30A 4kcnB-5ihvA:
undetectable		 4kcnB-5ihvA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbd TUMOR PROTEIN P73

(Homo sapiens) 		PF00870
(P53) 		4 GLU A 291
ARG A 293
ASP A 305
ASP A 301
 None
 1.34A 4kcnB-5kbdA:
undetectable		 4kcnB-5kbdA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 GLU A 309
ARG A 380
ASP A 311
ASP A 384
 None
 1.00A 4kcnB-5kf7A:
undetectable		 4kcnB-5kf7A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL

(Bos taurus;
Bos taurus) 		PF01058
(Oxidored_q6)
PF00346
(Complex1_49kDa) 		4 ARG B  66
GLU D 182
ARG D 183
ASP D 210
 None
 1.13A 4kcnB-5lc5B:
undetectable		 4kcnB-5lc5B:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll7 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 ARG A 161
ASP A 176
ASP A 163
ARG A 178
 None
 1.39A 4kcnB-5ll7A:
undetectable		 4kcnB-5ll7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLU A 171
ASP A 336
ASP A 335
ARG A 308
 MG  A 803 (-4.3A)
None
None
None
 1.39A 4kcnB-5mdnA:
undetectable		 4kcnB-5mdnA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLU A 393
ARG A 392
ASP A 112
ARG A  96
 None
 1.05A 4kcnB-5mdnA:
undetectable		 4kcnB-5mdnA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5

(Schizosaccharomyces
pombe) 		no annotation 4 GLU A 616
ARG A 609
ASP A 592
ARG A 587
 None
SO4  A 702 (-3.2A)
None
SO4  A 701 (-3.3A)
 1.34A 4kcnB-5mg8A:
undetectable		 4kcnB-5mg8A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE

(Enterobacter
cloacae) 		PF01977
(UbiD) 		4 ARG A 132
ASP A 178
ASP A 130
ARG A 177
 None
 1.22A 4kcnB-5ny5A:
undetectable		 4kcnB-5ny5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF01977
(UbiD) 		4 ARG A 132
ASP A 178
ASP A 130
ARG A 177
 None
 1.09A 4kcnB-5o3mA:
undetectable		 4kcnB-5o3mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uid AMINOTRANSFERASE
TLMJ

(Streptoalloteichus
hindustanus) 		PF01041
(DegT_DnrJ_EryC1) 		4 ARG A 167
GLU A 143
ASP A 174
ARG A 197
 None
 1.39A 4kcnB-5uidA:
undetectable		 4kcnB-5uidA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulj RAI1

(Scheffersomyces
stipitis) 		PF08652
(RAI1) 		4 GLU A 143
ASP A 141
ASP A 126
ARG A 354
 None
 1.30A 4kcnB-5uljA:
undetectable		 4kcnB-5uljA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b8d ELONGATION FACTOR G

(Haemophilus
influenzae) 		no annotation 4 ARG A  11
GLU A   8
ASP A 291
ARG A 253
 None
 1.27A 4kcnB-6b8dA:
undetectable		 4kcnB-6b8dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 ARG A 161
ASP A 176
ASP A 163
ARG A 178
 None
 1.38A 4kcnB-6bu3A:
undetectable		 4kcnB-6bu3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emg G0S4M2

(Chaetomium
thermophilum) 		no annotation 4 GLU A 206
ARG A 207
ASP A 203
ARG A 117
 None
EDO  A 308 (-3.5A)
None
EDO  A 306 (-4.0A)
 1.40A 4kcnB-6emgA:
undetectable		 4kcnB-6emgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eys -

(-) 		no annotation 4 ARG B 279
GLU B 440
ARG B 438
ASP B 436
 None
 1.11A 4kcnB-6eysB:
undetectable		 4kcnB-6eysB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus;
Influenza B
virus) 		no annotation
no annotation 		4 ARG C 218
ARG C 211
ASP B 655
ASP B 657
 None
 1.39A 4kcnB-6f5oC:
undetectable		 4kcnB-6f5oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkx ACETYL XYLAN
ESTERASE

(metagenome) 		no annotation 4 ARG C  31
ASP C  35
ASP C 150
ARG C 155
 None
 1.36A 4kcnB-6fkxC:
undetectable		 4kcnB-6fkxC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 4 GLU A 884
ARG A 910
ASP A 907
ARG A 903
 None
 1.15A 4kcnB-6fuyA:
undetectable		 4kcnB-6fuyA:
undetectable