SIMILAR PATTERNS OF AMINO ACIDS FOR 4KCN_A_ACTA803

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dci DIENOYL-COA
ISOMERASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 GLY A 172
ILE A 171
GLN A 193
VAL A 199
 None
None
SO4  A  14 (-3.2A)
None
 0.81A 4kcnA-1dciA:
0.0		 4kcnA-1dciA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 GLY A  38
ILE A  39
GLN A  37
TRP A 215
 None
 1.00A 4kcnA-1hl2A:
0.0		 4kcnA-1hl2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9l STATIONARY PHASE
SURVIVAL PROTEIN

(Thermotoga
maritima) 		PF01975
(SurE) 		4 GLY A  10
ILE A  11
GLN A  12
SER A  66
 None
 0.85A 4kcnA-1j9lA:
0.0		 4kcnA-1j9lA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		4 GLY A 205
ILE A 202
TRP A 211
VAL A 212
 FAD  A3005 (-3.3A)
None
None
None
 1.07A 4kcnA-1jroA:
undetectable		 4kcnA-1jroA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		6 GLY A 417
ILE A 419
GLN A 420
TRP A 587
VAL A 649
SER A 657
 ACT  A 860 ( 3.9A)
None
None
HEM  A 750 (-3.4A)
ACT  A 860 (-4.3A)
ACT  A 860 ( 3.9A)
 0.16A 4kcnA-1lzxA:
63.5		 4kcnA-1lzxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 GLY A 256
ILE A 306
VAL A 118
SER A 254
 PLP  A1110 (-3.2A)
PLP  A1110 (-4.5A)
None
PLP  A1110 ( 4.3A)
 1.04A 4kcnA-1m54A:
0.0		 4kcnA-1m54A:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 GLY A 186
ILE A 188
GLN A 189
TRP A 356
VAL A 418
 MPD  A 604 (-3.8A)
None
None
HEM  A 901 (-3.6A)
MPD  A 604 (-4.2A)
 0.13A 4kcnA-1m9qA:
59.8		 4kcnA-1m9qA:
64.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 ILE A 188
GLN A 189
TRP A 356
VAL A 418
SER A 426
 None
None
HEM  A 901 (-3.6A)
MPD  A 604 (-4.2A)
MPD  A 604 (-3.1A)
 0.64A 4kcnA-1m9qA:
59.8		 4kcnA-1m9qA:
64.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		4 GLY L  84
ILE L  88
TRP L  86
VAL L  66
 None
 1.10A 4kcnA-1pssL:
undetectable		 4kcnA-1pssL:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 GLY A 584
TRP A 581
VAL A 575
SER A 589
 None
 1.09A 4kcnA-1q8yA:
0.0		 4kcnA-1q8yA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		5 GLY A 196
ILE A 198
GLN A 199
TRP A 366
SER A 436
 HEM  A 900 ( 4.1A)
None
None
HEM  A 900 ( 3.5A)
None
 0.59A 4kcnA-1qw5A:
58.1		 4kcnA-1qw5A:
63.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE BETA
SUBUNIT

(Klebsiella
oxytoca) 		PF02288
(Dehydratase_MU) 		4 GLY B 127
ILE B 128
GLN B 142
SER B 129
 None
 1.02A 4kcnA-1uc4B:
undetectable		 4kcnA-1uc4B:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 GLY A 404
ILE A 405
GLN A 403
TRP A 165
 None
 1.00A 4kcnA-1w1kA:
undetectable		 4kcnA-1w1kA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9z VP9

(Banna virus) 		PF08978
(Reoviridae_Vp9) 		4 GLY A 271
ILE A 273
VAL A 227
SER A 142
 None
 1.09A 4kcnA-1w9zA:
undetectable		 4kcnA-1w9zA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		4 GLY A 202
ILE A 200
TRP A 341
VAL A 311
 None
 1.04A 4kcnA-1yt8A:
undetectable		 4kcnA-1yt8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		4 GLY A 182
ILE A 183
VAL A 133
SER A 217
 None
 0.97A 4kcnA-2aa4A:
undetectable		 4kcnA-2aa4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY C  69
ILE C  72
GLN C  64
VAL C 128
 None
 1.08A 4kcnA-2d3tC:
undetectable		 4kcnA-2d3tC:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekn PROBABLE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN
C

(Pyrococcus
horikoshii) 		PF01967
(MoaC) 		4 GLY A  62
ILE A  60
GLN A  59
VAL A  84
 None
 0.91A 4kcnA-2eknA:
undetectable		 4kcnA-2eknA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fne MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A2010
GLN A2008
VAL A2020
SER A2016
 None
 1.05A 4kcnA-2fneA:
undetectable		 4kcnA-2fneA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		4 ILE A  78
GLN A  95
VAL A  21
SER A  72
 None
None
OLA  A 130 ( 4.9A)
OLA  A 130 ( 3.8A)
 0.96A 4kcnA-2ftbA:
undetectable		 4kcnA-2ftbA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liv LEUCINE

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		4 GLY A  25
ILE A 265
GLN A  28
VAL A 312
 None
 1.01A 4kcnA-2livA:
undetectable		 4kcnA-2livA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4e O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00963
(Cohesin) 		4 GLY A 153
ILE A 151
VAL A  53
SER A 139
 None
 0.86A 4kcnA-2o4eA:
undetectable		 4kcnA-2o4eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 1.07A 4kcnA-2v9iA:
undetectable		 4kcnA-2v9iA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbk TAILSPIKE-PROTEIN

(Shigella virus
Sf6) 		PF12708
(Pectate_lyase_3) 		4 GLY A 302
ILE A 271
GLN A 301
VAL A 363
 None
 1.06A 4kcnA-2vbkA:
undetectable		 4kcnA-2vbkA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE

(Homo sapiens) 		PF00378
(ECH_1) 		4 GLY A 147
ILE A 146
GLN A 168
VAL A 174
 None
 0.83A 4kcnA-2vreA:
undetectable		 4kcnA-2vreA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		4 GLY A 370
ILE A 368
GLN A 371
SER A 282
 None
 1.10A 4kcnA-2w7yA:
undetectable		 4kcnA-2w7yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 GLY A 390
ILE A 389
VAL A 367
SER A 386
 None
 0.99A 4kcnA-2xpzA:
undetectable		 4kcnA-2xpzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 GLY A 686
ILE A 688
GLN A 684
VAL A 139
 None
 1.11A 4kcnA-2y3aA:
undetectable		 4kcnA-2y3aA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		4 GLY A  44
ILE A 448
GLN A 446
VAL A  30
 None
 0.86A 4kcnA-3a3iA:
undetectable		 4kcnA-3a3iA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak1 SUPEROXIDE DISMUTASE
[MN/FE]

(Aeropyrum
pernix) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLY A  75
ILE A  77
TRP A 130
VAL A 147
 None
 1.02A 4kcnA-3ak1A:
undetectable		 4kcnA-3ak1A:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 GLY A 202
ILE A 204
GLN A 205
TRP A 372
SER A 442
 HEM  A 901 ( 3.8A)
None
None
HEM  A 901 ( 3.7A)
None
 0.61A 4kcnA-3e7gA:
57.2		 4kcnA-3e7gA:
65.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		4 GLY A 163
ILE A 160
GLN A 164
VAL A  88
 None
 0.89A 4kcnA-3eqaA:
undetectable		 4kcnA-3eqaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 GLY A 355
ILE A 362
GLN A 354
VAL A 366
 None
 1.01A 4kcnA-3fefA:
undetectable		 4kcnA-3fefA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gei TRNA MODIFICATION
GTPASE MNME

(Chlorobaculum
tepidum) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 GLY A 454
ILE A 452
GLN A 451
VAL A 461
 None
 1.11A 4kcnA-3geiA:
undetectable		 4kcnA-3geiA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A  65
ILE A  68
GLN A  60
VAL A 124
 None
 1.03A 4kcnA-3goaA:
undetectable		 4kcnA-3goaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 GLY B 222
ILE B 224
VAL B 218
SER B 236
 None
 0.88A 4kcnA-3jcmB:
undetectable		 4kcnA-3jcmB:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE

(Cryptosporidium
parvum) 		PF00121
(TIM) 		4 GLY A 230
ILE A 223
VAL A 214
SER A 248
 None
 1.10A 4kcnA-3krsA:
undetectable		 4kcnA-3krsA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY B 136
ILE B 138
GLN B 135
SER B 148
 SF4  B 585 ( 4.9A)
None
SRM  A 580 (-3.5A)
None
 1.00A 4kcnA-3mm5B:
undetectable		 4kcnA-3mm5B:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nip 3-GUANIDINOPROPIONAS
E

(Pseudomonas
aeruginosa) 		PF00491
(Arginase) 		4 GLY A  41
ILE A  40
VAL A 128
SER A 121
 None
 1.09A 4kcnA-3nipA:
undetectable		 4kcnA-3nipA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8i PURINE NUCLEOSIDASE,
(IUNH-2)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		4 GLY A 233
ILE A 235
GLN A 229
SER A 194
 None
 0.92A 4kcnA-3t8iA:
undetectable		 4kcnA-3t8iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		4 GLY A 341
ILE A 339
VAL A  17
SER A 336
 None
 1.03A 4kcnA-3ue9A:
undetectable		 4kcnA-3ue9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 GLY A 564
ILE A 578
TRP A 607
VAL A 600
 None
 0.83A 4kcnA-3va6A:
undetectable		 4kcnA-3va6A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		4 GLY A 261
ILE A 296
VAL A 126
SER A 259
 SEP  A 402 ( 2.9A)
PLP  A 401 (-4.6A)
None
PLP  A 401 (-3.4A)
 0.84A 4kcnA-3vscA:
undetectable		 4kcnA-3vscA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		4 GLY A 320
ILE A 354
GLN A 321
VAL A 109
 None
 0.94A 4kcnA-3vsvA:
undetectable		 4kcnA-3vsvA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqu CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		4 GLY A  27
ILE A  28
GLN A 351
SER A 367
 None
 1.01A 4kcnA-3wquA:
undetectable		 4kcnA-3wquA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		4 GLY A  27
ILE A  28
GLN A 351
SER A 367
 None
 1.04A 4kcnA-3wt0A:
undetectable		 4kcnA-3wt0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b18 IMPORTIN SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 GLY A 169
ILE A 166
GLN A 167
VAL A 128
 None
 1.05A 4kcnA-4b18A:
undetectable		 4kcnA-4b18A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj8 ZEBAVIDIN

(Danio rerio) 		PF01382
(Avidin) 		4 GLY A  88
ILE A  84
GLN A  90
SER A   4
 None
 1.01A 4kcnA-4bj8A:
undetectable		 4kcnA-4bj8A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 GLY B 162
ILE B  93
GLN B  96
VAL B 123
 None
 1.07A 4kcnA-4ci2B:
undetectable		 4kcnA-4ci2B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 GLY X 220
ILE X 222
VAL X 275
SER X 249
 None
 1.06A 4kcnA-4crmX:
undetectable		 4kcnA-4crmX:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eps HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF13149
(Mfa_like_1) 		4 GLY A 302
ILE A 449
VAL A 216
SER A 448
 None
 1.02A 4kcnA-4epsA:
undetectable		 4kcnA-4epsA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		4 ILE A 354
GLN A 344
VAL A  51
SER A  45
 None
 1.10A 4kcnA-4f3eA:
undetectable		 4kcnA-4f3eA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffk SUPEROXIDE DISMUTASE

(Acidilobus
saccharovorans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLY A  88
ILE A  90
TRP A 143
VAL A 160
 None
 1.07A 4kcnA-4ffkA:
undetectable		 4kcnA-4ffkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igi COLLAGEN ALPHA3(VI)

(Mus musculus) 		PF00092
(VWA) 		4 GLY A1087
ILE A1089
GLN A1085
VAL A1064
 None
 0.97A 4kcnA-4igiA:
undetectable		 4kcnA-4igiA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		4 GLY A 149
ILE A 147
GLN A 148
VAL A 176
 None
 0.96A 4kcnA-4j7bA:
undetectable		 4kcnA-4j7bA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jde PROTEIN F15E11.13

(Caenorhabditis
elegans) 		no annotation 4 GLY A  78
ILE A 106
VAL A  31
SER A 107
 None
 1.00A 4kcnA-4jdeA:
undetectable		 4kcnA-4jdeA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7c AMINOPEPTIDASE C

(Lactobacillus
rhamnosus) 		PF03051
(Peptidase_C1_2) 		4 GLY A 370
ILE A  54
TRP A 381
SER A  53
 None
 0.82A 4kcnA-4k7cA:
undetectable		 4kcnA-4k7cA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 GLY A 143
ILE A 130
VAL A 101
SER A 310
 None
 0.95A 4kcnA-4kpgA:
undetectable		 4kcnA-4kpgA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq6 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

([Candida]
glabrata) 		PF00885
(DMRL_synthase) 		4 GLY A  21
ILE A  23
VAL A 121
SER A  68
 None
 1.10A 4kcnA-4kq6A:
undetectable		 4kcnA-4kq6A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 323
ILE A 325
VAL A 307
SER A 252
 None
 1.02A 4kcnA-4ktoA:
undetectable		 4kcnA-4ktoA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		no annotation 4 GLY B 256
ILE B 306
VAL B 118
SER B 254
 PLP  B 601 (-3.1A)
PLP  B 601 (-4.7A)
None
PLP  B 601 ( 3.9A)
 0.91A 4kcnA-4l27B:
undetectable		 4kcnA-4l27B:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 GLY A 143
ILE A 130
VAL A 101
SER A 310
 None
 0.93A 4kcnA-4m1zA:
undetectable		 4kcnA-4m1zA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 GLY A 245
ILE A 243
VAL A   5
SER A 321
 None
 0.98A 4kcnA-4m9dA:
undetectable		 4kcnA-4m9dA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 GLY A 246
ILE A 243
VAL A   5
SER A 321
 None
 0.99A 4kcnA-4m9dA:
undetectable		 4kcnA-4m9dA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qkw MUSCLE-RELATED
COILED-COIL PROTEIN

(Danio rerio) 		PF15237
(PTRF_SDPR) 		4 GLY A  37
ILE A  35
GLN A  39
SER A  32
 None
 0.86A 4kcnA-4qkwA:
undetectable		 4kcnA-4qkwA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8u DNA POLYMERASE IV

(Escherichia
coli) 		PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C) 		4 GLY B 220
ILE B 222
TRP B 224
VAL B 204
 None
 1.03A 4kcnA-4r8uB:
undetectable		 4kcnA-4r8uB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLY A 141
ILE A 177
GLN A 223
VAL A 246
 None
ACT  A 433 ( 3.8A)
None
None
 0.99A 4kcnA-4rs3A:
undetectable		 4kcnA-4rs3A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLY A 141
ILE A 177
GLN A 223
VAL A 246
 None
 1.06A 4kcnA-4rsmA:
undetectable		 4kcnA-4rsmA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)

(Agrobacterium
vitis) 		PF01547
(SBP_bac_1) 		4 GLY A  93
ILE A  91
GLN A  95
VAL A  72
 None
 0.87A 4kcnA-4ryaA:
undetectable		 4kcnA-4ryaA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
BETA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		4 GLY B 170
ILE B 168
GLN B 171
VAL B 175
 None
 1.11A 4kcnA-4wvmB:
undetectable		 4kcnA-4wvmB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Streptobacillus
moniliformis) 		PF13407
(Peripla_BP_4) 		4 GLY A 145
ILE A 142
GLN A 146
VAL A 278
 None
 0.99A 4kcnA-4z0nA:
undetectable		 4kcnA-4z0nA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e44 FNR REGULATOR

(Aliivibrio
fischeri) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 GLY A 153
ILE A 151
GLN A 155
SER A 148
 MPD  A 302 (-4.0A)
None
None
None
 0.91A 4kcnA-5e44A:
undetectable		 4kcnA-5e44A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		4 GLY A 413
ILE A 412
VAL A  24
SER A 409
 None
 1.08A 4kcnA-5esoA:
undetectable		 4kcnA-5esoA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 GLY A  70
ILE A  71
VAL A  23
SER A 164
 None
None
PPV  A1339 (-4.0A)
PPV  A1339 (-3.2A)
 1.09A 4kcnA-5fo1A:
undetectable		 4kcnA-5fo1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		4 GLY A 481
ILE A 483
GLN A 479
VAL A 159
 None
 1.07A 4kcnA-5fsaA:
undetectable		 4kcnA-5fsaA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hou CELLULAR TUMOR
ANTIGEN
P53,CREB-BINDING
PROTEIN FUSION
PROTEIN

(Homo sapiens;
Mus musculus) 		PF02135
(zf-TAZ)
PF08563
(P53_TAD) 		4 ILE A1050
GLN A3356
VAL A3390
SER A3410
 None
 1.04A 4kcnA-5houA:
undetectable		 4kcnA-5houA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 GLY Z 161
ILE Z  92
GLN Z  95
VAL Z 122
 None
 1.05A 4kcnA-5hxbZ:
undetectable		 4kcnA-5hxbZ:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL

(Homo sapiens) 		PF03109
(ABC1) 		4 GLY A 342
ILE A 341
GLN A 360
SER A 340
 None
None
None
ANP  A 700 (-2.8A)
 1.06A 4kcnA-5i35A:
undetectable		 4kcnA-5i35A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF00106
(adh_short) 		4 GLY A 131
ILE A 128
GLN A 132
VAL A 181
 None
 0.98A 4kcnA-5ig2A:
undetectable		 4kcnA-5ig2A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1g PLECTIN

(Homo sapiens) 		no annotation 4 GLY A1124
ILE A1122
GLN A1126
SER A1119
 None
 0.86A 4kcnA-5j1gA:
undetectable		 4kcnA-5j1gA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1i PLECTIN

(Homo sapiens) 		no annotation 4 GLY A1124
ILE A1122
GLN A1126
SER A1119
 None
 0.93A 4kcnA-5j1iA:
undetectable		 4kcnA-5j1iA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE

(Aspergillus
flavus) 		PF00743
(FMO-like) 		4 GLY A 455
ILE A 451
GLN A 454
SER A  23
 None
None
None
FAD  A 601 (-2.7A)
 0.92A 4kcnA-5j7xA:
undetectable		 4kcnA-5j7xA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jor FAB14.22 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  42
ILE B  40
GLN B  41
SER B  44
 1PE  B 309 ( 3.9A)
None
1PE  B 310 ( 3.5A)
None
 1.07A 4kcnA-5jorB:
undetectable		 4kcnA-5jorB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 GLY A 349
ILE A 252
TRP A 339
VAL A 298
 None
 0.95A 4kcnA-5jouA:
undetectable		 4kcnA-5jouA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 GLY A 655
ILE A 657
TRP A 574
VAL A 602
 None
 0.88A 4kcnA-5kf7A:
undetectable		 4kcnA-5kf7A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1x HMPV F1 SUBUNIT

(Human
metapneumovirus) 		PF00523
(Fusion_gly) 		4 GLY B 393
ILE B 399
VAL B 424
SER B 391
 None
 0.93A 4kcnA-5l1xB:
undetectable		 4kcnA-5l1xB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)

(Aquifex
aeolicus) 		no annotation 4 GLY B 277
ILE B 279
VAL B 149
SER B  40
 None
 1.06A 4kcnA-5l22B:
undetectable		 4kcnA-5l22B:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li4 TAIL SHEATH PROTEIN

(Staphylococcus
phage 812) 		no annotation 4 GLY A  40
ILE A  92
GLN A  41
VAL A 344
 None
 0.98A 4kcnA-5li4A:
undetectable		 4kcnA-5li4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mms CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 GLY A 256
ILE A 306
VAL A 118
SER A 254
 PLP  A1002 (-3.6A)
PLP  A1002 (-4.7A)
None
PLP  A1002 (-3.7A)
 0.93A 4kcnA-5mmsA:
undetectable		 4kcnA-5mmsA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L6

(Mycolicibacterium
smegmatis) 		PF00347
(Ribosomal_L6) 		4 GLY G   5
ILE G   4
GLN G   7
VAL G   9
 None
A  A2973 ( 4.5A)
None
None
 1.01A 4kcnA-5o60G:
undetectable		 4kcnA-5o60G:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B

(Methanothermococcus
thermolithotrophicus) 		PF02754
(CCG) 		4 GLY B 241
ILE B 243
GLN B 281
VAL B 257
 None
 1.04A 4kcnA-5odrB:
undetectable		 4kcnA-5odrB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or7 CAPSID PROTEIN
CMRF35-LIKE MOLECULE
1

(Norwalk virus;
Mus musculus) 		no annotation
no annotation 		4 GLY A 333
ILE A 358
GLN A 334
SER C  43
 None
 0.92A 4kcnA-5or7A:
undetectable		 4kcnA-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sup ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A  99
ILE A  97
VAL A 102
SER A 119
 None
 1.09A 4kcnA-5supA:
undetectable		 4kcnA-5supA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suq ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A  99
ILE A  97
VAL A 102
SER A 119
 None
 1.09A 4kcnA-5suqA:
undetectable		 4kcnA-5suqA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0y HYDROPHOBIN

(Serpula
lacrymans) 		no annotation 4 GLY A  53
ILE A  54
VAL A  12
SER A  60
 None
 1.06A 4kcnA-5w0yA:
undetectable		 4kcnA-5w0yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6

(Saccharomyces
cerevisiae) 		PF10214
(Rrn6) 		4 GLY O 262
ILE O 263
GLN O 270
VAL O 286
 None
 1.08A 4kcnA-5w5yO:
undetectable		 4kcnA-5w5yO:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0b FRIZZLED-2

(Homo sapiens) 		no annotation 4 GLY B 152
ILE B 113
GLN B 153
SER B 112
 None
 1.09A 4kcnA-6c0bB:
undetectable		 4kcnA-6c0bB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 5 GLY B 309
ILE B 311
GLN B 362
VAL B 573
SER B 291
 None
 1.16A 4kcnA-6f0kB:
undetectable		 4kcnA-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 4 GLY A 163
ILE A 160
GLN A 164
VAL A  88
 None
 0.98A 4kcnA-6frvA:
undetectable		 4kcnA-6frvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Acanthamoeba
castellanii) 		no annotation 4 GLY A  77
ILE A  74
GLN A  78
VAL A  19
 None
 0.89A 4kcnA-6fwhA:
undetectable		 4kcnA-6fwhA:
undetectable