SIMILAR PATTERNS OF AMINO ACIDS FOR 4K7G_B_ACTB902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak0 P1 NUCLEASE

(Penicillium
citrinum) 		PF02265
(S1-P1_nuclease) 		4 ASP A  45
TRP A   1
HIS A 116
SER A  42
 ZN  A 271 (-3.2A)
None
ZN  A 271 (-3.5A)
None
 1.13A 4k7gB-1ak0A:
0.0		 4k7gB-1ak0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 ASP A  81
ASP A  48
HIS A  77
SER A  82
 ZN  A 501 ( 2.7A)
None
ZN  A 500 (-3.4A)
None
 1.20A 4k7gB-1ddkA:
0.0		 4k7gB-1ddkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PRO A  26
ASP A 172
TRP A  32
SER A  18
 None
 1.19A 4k7gB-1fnoA:
undetectable		 4k7gB-1fnoA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 PRO A  41
ASP A 341
HIS A 374
SER A 340
 None
 1.23A 4k7gB-1hkwA:
0.0		 4k7gB-1hkwA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oq1 PROTEIN YESU

(Bacillus
subtilis) 		PF09224
(DUF1961) 		4 PRO A  12
ASP A  18
SER A  15
SER A  17
 None
 1.23A 4k7gB-1oq1A:
0.0		 4k7gB-1oq1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut4 NO APICAL MERISTEM
PROTEIN

(Arabidopsis
thaliana) 		PF02365
(NAM) 		4 PRO A  56
ASP A  55
TRP A 132
SER A  92
 None
 1.26A 4k7gB-1ut4A:
0.0		 4k7gB-1ut4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		4 ASP A 245
SER A 244
HIS A 251
SER A 282
 None
 1.25A 4k7gB-1w55A:
undetectable		 4k7gB-1w55A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM

(Bacillus
subtilis) 		PF00724
(Oxidored_FMN) 		4 ASP A 220
SER A 179
HIS A 172
SER A 176
 None
 1.05A 4k7gB-1z48A:
0.2		 4k7gB-1z48A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
furiosus) 		PF01470
(Peptidase_C15) 		4 PRO A  61
SER A 162
HIS A  66
SER A 149
 None
 1.19A 4k7gB-1z8wA:
0.0		 4k7gB-1z8wA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 ASP A 389
ASP A 387
SER A 175
HIS A 350
 None
UNX  A 601 ( 2.6A)
UNX  A 601 ( 1.8A)
VO4  A 801 (-3.8A)
 1.17A 4k7gB-2d1gA:
undetectable		 4k7gB-2d1gA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4a MALATE DEHYDROGENASE

(Aeropyrum
pernix) 		no annotation 4 ASP B 145
SER B 247
HIS B 172
SER B 141
 None
 1.13A 4k7gB-2d4aB:
undetectable		 4k7gB-2d4aB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1

(Homo sapiens) 		no annotation 4 ASP A  64
PRO A 104
ASP A 105
SER A  95
 None
 1.05A 4k7gB-2d58A:
undetectable		 4k7gB-2d58A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nli LACTATE OXIDASE

(Aerococcus
viridans) 		PF01070
(FMN_dh) 		4 ASP A 296
SER A 297
HIS A 265
SER A 263
 FMN  A1375 (-2.8A)
FMN  A1375 (-4.0A)
PEO  A1377 ( 4.0A)
FMN  A1375 (-3.3A)
 0.83A 4k7gB-2nliA:
undetectable		 4k7gB-2nliA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PRO A 288
SER A 331
HIS A 340
SER A 327
 None
 1.05A 4k7gB-2nqlA:
undetectable		 4k7gB-2nqlA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 ASP A 639
SER A 638
HIS A 657
SER A 661
 None
NAP  A 903 ( 4.7A)
NAP  A 903 (-4.2A)
None
 0.86A 4k7gB-2o2qA:
undetectable		 4k7gB-2o2qA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofx BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		PF01583
(APS_kinase) 		4 ASP A 159
PRO A 161
ASP A 205
SER A 206
 None
PO4  A 403 (-4.2A)
None
None
 1.27A 4k7gB-2ofxA:
undetectable		 4k7gB-2ofxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PRO A 289
SER A 332
HIS A 341
SER A 328
 None
 1.12A 4k7gB-2ppgA:
undetectable		 4k7gB-2ppgA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 4 PRO A 257
SER A 313
TRP A 311
HIS A 292
 None
 1.05A 4k7gB-2quaA:
undetectable		 4k7gB-2quaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		4 ASP A  23
ASP A  97
SER A  73
SER A  70
 None
 1.26A 4k7gB-2qzxA:
undetectable		 4k7gB-2qzxA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 ASP A 939
PRO A 942
ASP A 946
SER A 955
 CA  A1173 ( 2.9A)
None
CA  A1173 ( 2.1A)
CA  A1173 (-2.9A)
 1.27A 4k7gB-2rhpA:
undetectable		 4k7gB-2rhpA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD

(Homo sapiens) 		PF00443
(UCH) 		4 ASP A 889
SER A 605
HIS A 871
SER A 890
 None
 1.24A 4k7gB-2vhfA:
undetectable		 4k7gB-2vhfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 ASP A 872
SER A 871
TRP A 869
SER A 902
 None
 1.20A 4k7gB-2wfhA:
undetectable		 4k7gB-2wfhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wt9 NICOTINAMIDASE

(Acinetobacter
baumannii) 		PF00857
(Isochorismatase) 		4 ASP A  54
ASP A 121
SER A  62
HIS A  89
 ZN  A1212 ( 2.6A)
ZN  A1212 ( 4.1A)
ZN  A1212 ( 4.4A)
ZN  A1212 ( 3.5A)
 0.98A 4k7gB-2wt9A:
undetectable		 4k7gB-2wt9A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 ASP A 642
PRO A  87
SER A  34
SER A  39
 None
 1.27A 4k7gB-2wzsA:
undetectable		 4k7gB-2wzsA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xde GAG POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00607
(Gag_p24) 		4 PRO A  99
ASP A 103
SER A 102
TRP A  80
 None
 1.21A 4k7gB-2xdeA:
undetectable		 4k7gB-2xdeA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xlr FLAVIN-CONTAINING
MONOOXYGENASE

(Methylophaga
aminisulfidivorans) 		PF00743
(FMO-like) 		4 SER A  70
TRP A  52
HIS A  68
SER A 171
 FAD  A 500 ( 4.3A)
FAD  A 500 (-4.2A)
FAD  A 500 (-3.4A)
None
 1.25A 4k7gB-2xlrA:
undetectable		 4k7gB-2xlrA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		4 PRO A 256
SER A 312
TRP A 310
HIS A 291
 None
 1.10A 4k7gB-2z8zA:
undetectable		 4k7gB-2z8zA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 PRO A 366
ASP A 362
SER A 361
TRP A 359
 None
 1.23A 4k7gB-2zpaA:
undetectable		 4k7gB-2zpaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abi PUTATIVE
UNCHARACTERIZED
PROTEIN PH1688

(Pyrococcus
horikoshii) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 ASP A 265
SER A 296
TRP A 160
SER A 293
 None
None
SO4  A2001 ( 4.0A)
None
 1.24A 4k7gB-3abiA:
undetectable		 4k7gB-3abiA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		4 ASP A  59
PRO A 149
ASP A 147
SER A 105
 None
 1.27A 4k7gB-3aivA:
undetectable		 4k7gB-3aivA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA

(Pseudomonas
aeruginosa) 		PF05141
(DIT1_PvcA) 		4 PRO A  63
ASP A 113
SER A 235
HIS A 255
 PO4  A 329 ( 4.9A)
None
PO4  A 329 ( 4.5A)
PO4  A 329 (-4.0A)
 1.14A 4k7gB-3e59A:
undetectable		 4k7gB-3e59A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		4 PRO A 222
ASP A 219
HIS A 229
SER A  79
 None
 1.23A 4k7gB-3fw6A:
undetectable		 4k7gB-3fw6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
mutans) 		PF01791
(DeoC) 		4 ASP A  16
SER A  65
TRP A 322
SER A  22
 None
 1.13A 4k7gB-3iv3A:
undetectable		 4k7gB-3iv3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 PRO A 147
ASP A 134
SER A 135
SER A 136
 None
 1.16A 4k7gB-3j4uA:
undetectable		 4k7gB-3j4uA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		4 ASP A 147
SER A   8
TRP A 152
SER A  28
 GOL  A 501 (-3.2A)
AMP  A 509 (-2.7A)
AMP  A 509 (-4.1A)
AMP  A 509 ( 4.5A)
 1.09A 4k7gB-3kd6A:
undetectable		 4k7gB-3kd6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Thermoanaerobacter
pseudethanolicus) 		PF00724
(Oxidored_FMN) 		4 ASP A 221
SER A 178
HIS A 171
SER A 175
 None
 1.02A 4k7gB-3krzA:
undetectable		 4k7gB-3krzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lr1 TUNGSTATE ABC
TRANSPORTER,
PERIPLASMIC
TUNGSTATE-BINDING
PROTEIN

(Geobacter
sulfurreducens) 		PF12849
(PBP_like_2) 		4 PRO A 139
SER A 117
TRP A 132
HIS A 125
 None
 1.20A 4k7gB-3lr1A:
undetectable		 4k7gB-3lr1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC

(Escherichia
coli) 		no annotation 4 ASP A 345
SER A 354
TRP A 488
HIS A 349
 None
 1.22A 4k7gB-3ly9A:
undetectable		 4k7gB-3ly9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muq UNCHARACTERIZED
CONSERVED PROTEIN

(Vibrio
parahaemolyticus) 		PF12849
(PBP_like_2) 		4 PRO A 164
SER A 142
TRP A 157
HIS A 150
 None
 1.17A 4k7gB-3muqA:
undetectable		 4k7gB-3muqA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muq UNCHARACTERIZED
CONSERVED PROTEIN

(Vibrio
parahaemolyticus) 		PF12849
(PBP_like_2) 		4 PRO A 164
SER A 171
TRP A 157
HIS A 150
 None
 0.96A 4k7gB-3muqA:
undetectable		 4k7gB-3muqA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 PRO A 421
ASP A  22
HIS A 359
SER A  74
 None
CO  A 553 (-2.1A)
None
CO  A 553 (-2.2A)
 1.13A 4k7gB-3nvlA:
undetectable		 4k7gB-3nvlA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN

(Leishmania
infantum) 		PF00857
(Isochorismatase) 		4 ASP A  73
ASP A 124
SER A  81
HIS A  92
 ZN  A 301 ( 2.5A)
ZN  A 301 ( 4.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 ( 3.4A)
 0.96A 4k7gB-3r2jA:
undetectable		 4k7gB-3r2jA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6m YEAZ, RESUSCITATION
PROMOTING FACTOR

(Vibrio
parahaemolyticus) 		PF00814
(Peptidase_M22) 		4 PRO A 190
ASP A 191
SER A 192
SER A  15
 None
 1.21A 4k7gB-3r6mA:
undetectable		 4k7gB-3r6mA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE

(Leptospirillum
rubarum) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ASP A   7
ASP A 196
SER A 198
SER A 199
 None
 1.07A 4k7gB-3ttgA:
undetectable		 4k7gB-3ttgA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans) 		PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set) 		4 ASP A 194
PRO A  96
HIS A 461
SER A 193
 None
 1.27A 4k7gB-3utoA:
undetectable		 4k7gB-3utoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 4 ASP A 327
SER A  54
TRP A 331
SER A  56
 None
None
L6S  A1610 (-3.8A)
None
 1.21A 4k7gB-4aw7A:
undetectable		 4k7gB-4aw7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 ASP A 152
SER A 209
TRP A 225
HIS A 211
 None
 1.02A 4k7gB-4azwA:
undetectable		 4k7gB-4azwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		4 ASP A 678
SER A 680
HIS A 656
SER A 655
 None
 1.27A 4k7gB-4ecnA:
undetectable		 4k7gB-4ecnA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		no annotation 4 ASP A 170
SER A 172
HIS A 149
SER A 148
 None
 1.25A 4k7gB-4ezgA:
undetectable		 4k7gB-4ezgA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsj CAPSID PROTEIN BETA

(Flock House
virus) 		PF01829
(Peptidase_A6) 		4 ASP A  79
PRO A  73
SER A 170
TRP A 316
 None
 1.25A 4k7gB-4fsjA:
undetectable		 4k7gB-4fsjA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcm THIOREDOXIN
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		4 ASP A 223
SER A 225
HIS A 201
SER A 220
 None
 1.24A 4k7gB-4gcmA:
undetectable		 4k7gB-4gcmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 PRO A 386
ASP A 389
SER A 331
SER A 329
 ACT  A 507 (-4.8A)
None
None
None
 1.24A 4k7gB-4hucA:
undetectable		 4k7gB-4hucA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxx METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 ASP A 160
ASP A 385
SER A 386
HIS A 390
 None
 1.22A 4k7gB-4hxxA:
undetectable		 4k7gB-4hxxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		4 ASP A  97
PRO A  31
ASP A  32
HIS A 267
 PEG  A 302 ( 4.7A)
None
None
None
 0.93A 4k7gB-4inzA:
undetectable		 4k7gB-4inzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu6 METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 ASP A 160
ASP A 385
SER A 386
HIS A 390
 None
 1.25A 4k7gB-4iu6A:
undetectable		 4k7gB-4iu6A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jde PROTEIN F15E11.13

(Caenorhabditis
elegans) 		no annotation 4 ASP A 121
SER A 141
HIS A 115
SER A 139
 None
 1.27A 4k7gB-4jdeA:
undetectable		 4k7gB-4jdeA:
16.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		7 ASP B  85
PRO B  88
ASP B 172
SER B 173
TRP B 219
HIS B 221
SER B 223
 ACT  B 902 (-3.8A)
ACT  B 902 (-4.0A)
ACT  B 902 (-3.5A)
ACT  B 902 (-2.5A)
None
ACT  B 902 (-3.7A)
ACT  B 902 (-3.1A)
 0.00A 4k7gB-4k7gB:
64.5		 4k7gB-4k7gB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		5 PRO B  87
ASP B 172
SER B 173
HIS B 221
SER B 223
 None
ACT  B 902 (-3.5A)
ACT  B 902 (-2.5A)
ACT  B 902 (-3.7A)
ACT  B 902 (-3.1A)
 1.36A 4k7gB-4k7gB:
64.5		 4k7gB-4k7gB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k8l PROLINE RACEMASE

(Ochrobactrum
anthropi) 		PF05544
(Pro_racemase) 		4 ASP A  85
PRO A  88
SER A 173
SER A 222
 None
 1.00A 4k7gB-4k8lA:
44.4		 4k7gB-4k8lA:
75.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k8l PROLINE RACEMASE

(Ochrobactrum
anthropi) 		PF05544
(Pro_racemase) 		5 PRO A  88
ASP A 172
SER A 173
HIS A 220
SER A 222
 None
 0.31A 4k7gB-4k8lA:
44.4		 4k7gB-4k8lA:
75.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3f INTERNALIN K

(Listeria
monocytogenes) 		no annotation 4 ASP A 177
SER A 179
HIS A 156
SER A 155
 None
 1.28A 4k7gB-4l3fA:
undetectable		 4k7gB-4l3fA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ASP A 119
SER A 291
HIS A 263
SER A 289
 None
None
AG8  A 901 (-3.9A)
None
 1.19A 4k7gB-4lixA:
undetectable		 4k7gB-4lixA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ASP A 393
ASP A 414
SER A 437
SER A 416
 None
 0.83A 4k7gB-4mn8A:
undetectable		 4k7gB-4mn8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ASP A 414
SER A 437
HIS A 417
SER A 416
 None
 1.24A 4k7gB-4mn8A:
undetectable		 4k7gB-4mn8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ASP A 393
ASP A 414
SER A 437
SER A 416
 None
 0.88A 4k7gB-4mnaA:
undetectable		 4k7gB-4mnaA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ASP A 414
SER A 437
HIS A 417
SER A 416
 None
 1.23A 4k7gB-4mnaA:
undetectable		 4k7gB-4mnaA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		4 PRO A  78
ASP A  31
SER A  29
HIS A 145
 None
 1.28A 4k7gB-4ng3A:
undetectable		 4k7gB-4ng3A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o66 SWI/SNF-RELATED
MATRIX-ASSOCIATED
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
A-LIKE PROTEIN 1

(Mus musculus) 		PF07443
(HARP) 		4 PRO A 232
ASP A 249
SER A 246
SER A 248
 None
 1.25A 4k7gB-4o66A:
undetectable		 4k7gB-4o66A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9d RIK1-ASSOCIATED
FACTOR 1

(Schizosaccharomyces
pombe) 		no annotation 4 ASP B 414
SER B 392
HIS B 344
SER B 394
 None
 1.28A 4k7gB-4o9dB:
undetectable		 4k7gB-4o9dB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		4 ASP A 438
PRO A 442
SER A 410
SER A 412
 None
 1.06A 4k7gB-4oe5A:
undetectable		 4k7gB-4oe5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8l ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		4 ASP A  95
ASP A 176
SER A 177
SER A  94
 None
 1.09A 4k7gB-4q8lA:
undetectable		 4k7gB-4q8lA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtf L,D-TRANSPEPTIDASE
LDTB

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 PRO A 386
ASP A 389
SER A 331
SER A 329
 None
 1.22A 4k7gB-4qtfA:
undetectable		 4k7gB-4qtfA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 4 ASP A 380
SER A 353
HIS A 351
SER A 379
 None
 1.12A 4k7gB-4ru5A:
undetectable		 4k7gB-4ru5A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Aggregatibacter
actinomycetemcomitans) 		PF01522
(Polysacc_deac_1) 		4 ASP A 129
ASP A 170
SER A 215
SER A 125
 None
 1.23A 4k7gB-4u10A:
undetectable		 4k7gB-4u10A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 ASP A  50
ASP A 123
SER A 119
HIS A 115
 None
 0.95A 4k7gB-4zrsA:
0.5		 4k7gB-4zrsA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a52 CALCIUM-DEPENDENT
LIPID-BINDING
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00168
(C2) 		4 ASP A  27
SER A  24
HIS A  46
SER A  25
 CA  A1164 (-3.7A)
None
None
None
 1.15A 4k7gB-5a52A:
undetectable		 4k7gB-5a52A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		4 ASP E 149
SER E 150
HIS E 241
SER E 147
 None
 0.82A 4k7gB-5b04E:
undetectable		 4k7gB-5b04E:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		4 PRO A 218
SER A 258
TRP A 260
SER A 268
 None
 1.15A 4k7gB-5bwiA:
undetectable		 4k7gB-5bwiA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		4 ASP A 483
SER A 106
HIS A  97
SER A 104
 None
 1.03A 4k7gB-5d6aA:
undetectable		 4k7gB-5d6aA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gll GLYCOSIDE HYDROLASE
FAMILY 43

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		4 ASP A 128
SER A 321
HIS A  61
SER A  59
 None
None
None
CA  A 401 ( 3.7A)
 1.15A 4k7gB-5gllA:
undetectable		 4k7gB-5gllA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		4 ASP A  74
ASP A  21
TRP A  23
SER A  54
 BEM  A 503 ( 3.7A)
None
None
None
 1.20A 4k7gB-5h71A:
undetectable		 4k7gB-5h71A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipy FLAVIN-CONTAINING
MONOOXYGENASE

(Roseovarius
nubinhibens) 		PF00743
(FMO-like) 		4 SER A  65
TRP A  47
HIS A  63
SER A 166
 FAD  A 502 (-4.4A)
FAD  A 502 (-4.0A)
FAD  A 502 (-3.4A)
FAD  A 502 ( 4.5A)
 1.09A 4k7gB-5ipyA:
undetectable		 4k7gB-5ipyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8j HISTONE DEACETYLASE
HDA1

(Saccharomyces
cerevisiae) 		PF09757
(Arb2) 		4 ASP A 550
ASP A 532
HIS A 507
SER A 534
 None
 1.18A 4k7gB-5j8jA:
0.7		 4k7gB-5j8jA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k69 L,D-TRANSPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 PRO A 386
ASP A 389
SER A 331
SER A 329
 None
 1.19A 4k7gB-5k69A:
undetectable		 4k7gB-5k69A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		4 ASP A 244
SER A 253
HIS A 467
SER A 254
 None
 1.16A 4k7gB-5kojA:
undetectable		 4k7gB-5kojA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 SER A 100
TRP A 137
HIS A 107
SER A 160
 SO4  A1004 ( 4.9A)
None
ZN  A1001 ( 3.1A)
None
 1.24A 4k7gB-5lewA:
undetectable		 4k7gB-5lewA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		4 ASP A 147
ASP A  62
SER A 127
HIS A 116
 None
 1.29A 4k7gB-5mifA:
1.2		 4k7gB-5mifA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng7 EPOXIDE HYDROLASE

(metagenome) 		no annotation 4 ASP A 101
PRO A  35
ASP A  36
HIS A 270
 None
 1.17A 4k7gB-5ng7A:
undetectable		 4k7gB-5ng7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 4 ASP A 623
PRO A 604
ASP A 721
SER A 718
 None
 0.91A 4k7gB-5ngyA:
undetectable		 4k7gB-5ngyA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		4 ASP A 288
SER A 140
HIS A 294
SER A 290
 None
 1.09A 4k7gB-5o0sA:
undetectable		 4k7gB-5o0sA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis) 		no annotation 4 ASP A  97
PRO A 226
ASP A 106
SER A  95
 None
 1.25A 4k7gB-5odoA:
undetectable		 4k7gB-5odoA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 ASP p  88
SER p  84
HIS p  66
SER p  86
 None
 1.27A 4k7gB-5optp:
undetectable		 4k7gB-5optp:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA

(Pseudomonas
aeruginosa) 		PF16957
(Mal_decarbox_Al) 		4 ASP A 204
PRO A 201
ASP A 334
SER A 336
 None
 1.20A 4k7gB-5vj1A:
undetectable		 4k7gB-5vj1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN

(Lama glama;
Human
betaherpesvirus
5) 		no annotation 4 ASP A1106
PRO A 997
SER A 220
HIS A 222
 None
 1.22A 4k7gB-5wb1A:
undetectable		 4k7gB-5wb1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpi HSVA

(Erwinia
amylovora) 		no annotation 4 ASP A  36
PRO A  96
HIS A 101
SER A  99
 ASP  A  36 ( 0.6A)
PRO  A  96 ( 1.1A)
HIS  A 101 ( 1.0A)
SER  A  99 ( 0.0A)
 1.16A 4k7gB-5wpiA:
undetectable		 4k7gB-5wpiA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 4 ASP A 465
ASP A 422
HIS A 479
SER A 424
 None
None
GOL  A 816 (-3.8A)
None
 1.20A 4k7gB-5x3jA:
0.4		 4k7gB-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		4 PRO A1001
ASP A 368
TRP A1004
SER A 371
 None
 1.07A 4k7gB-5y7oA:
undetectable		 4k7gB-5y7oA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 ASP A 528
SER A 530
HIS A 506
SER A 505
 None
 1.27A 4k7gB-5zlnA:
undetectable		 4k7gB-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eys -

(-) 		no annotation 4 ASP B 312
PRO B 291
SER B 430
TRP B 382
 None
 1.12A 4k7gB-6eysB:
undetectable		 4k7gB-6eysB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 4 PRO A 255
SER A 251
HIS A  86
SER A 154
 None
 1.16A 4k7gB-6f9mA:
undetectable		 4k7gB-6f9mA:
undetectable