SIMILAR PATTERNS OF AMINO ACIDS FOR 4K7A_A_MXDA1002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		3 GLU A 107
TRP A  39
LYS A  48
 None
 1.42A 4k7aA-1b5fA:
undetectable		 4k7aA-1b5fA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 GLU B 342
TRP C 111
LYS B 293
 None
 0.93A 4k7aA-1e6vB:
0.0		 4k7aA-1e6vB:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 GLU A1136
TRP A1140
LYS A1130
 None
 1.43A 4k7aA-1f20A:
0.0		 4k7aA-1f20A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 GLU A 237
TRP A 249
LYS A 231
 None
 1.47A 4k7aA-1h8lA:
0.0		 4k7aA-1h8lA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m56 CYTOCHROME C OXIDASE

(Rhodobacter
sphaeroides) 		PF00510
(COX3) 		3 GLU C 241
TRP C 245
LYS C 236
 None
PEH  C2013 (-3.3A)
PEH  C2008 ( 4.3A)
 1.43A 4k7aA-1m56C:
0.9		 4k7aA-1m56C:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF09291
(DUF1968) 		3 GLU E 132
TRP E 204
LYS D 132
 None
 1.49A 4k7aA-1mi5E:
undetectable		 4k7aA-1mi5E:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 GLU A 233
TRP A 235
LYS A 243
 None
 1.23A 4k7aA-1mu2A:
0.0		 4k7aA-1mu2A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		3 GLU A 294
TRP A 295
LYS A 291
 None
 1.24A 4k7aA-1qu2A:
1.5		 4k7aA-1qu2A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vff BETA-GLUCOSIDASE

(Pyrococcus
horikoshii) 		PF00232
(Glyco_hydro_1) 		3 GLU A 324
TRP A 362
LYS A 207
 None
 1.37A 4k7aA-1vffA:
undetectable		 4k7aA-1vffA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmf HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01894
(UPF0047) 		3 GLU A  50
TRP A 109
LYS A  57
 None
 1.41A 4k7aA-1vmfA:
undetectable		 4k7aA-1vmfA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		3 GLU A 227
TRP A  95
LYS A 255
 None
None
PLP  A 418 (-1.3A)
 1.37A 4k7aA-1wstA:
undetectable		 4k7aA-1wstA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 GLU A 793
TRP A 796
LYS A 861
 None
 0.34A 4k7aA-2ax9A:
41.3		 4k7aA-2ax9A:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2y CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF00385
(Chromo) 		3 GLU C  14
TRP C  64
LYS C  11
 None
 1.50A 4k7aA-2b2yC:
undetectable		 4k7aA-2b2yC:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1f THREONINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		3 GLU A 179
TRP A  12
LYS A 174
 None
 1.43A 4k7aA-2d1fA:
undetectable		 4k7aA-2d1fA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE

(Cellulomonas
fimi) 		PF00331
(Glyco_hydro_10) 		3 GLU A  36
TRP A 295
LYS A   1
 None
 0.85A 4k7aA-2hisA:
undetectable		 4k7aA-2hisA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 GLU A 273
TRP A  51
LYS A 275
 None
 1.30A 4k7aA-2i14A:
undetectable		 4k7aA-2i14A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6p PHAC1, PHAC2 AND
PHAD GENES

(Pseudomonas
aeruginosa) 		PF06155
(DUF971) 		3 GLU A  31
TRP A  99
LYS A  15
 None
 1.24A 4k7aA-2l6pA:
undetectable		 4k7aA-2l6pA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljf INTEGRIN BETA-3

(Homo sapiens) 		PF08725
(Integrin_b_cyt) 		3 GLU A 726
TRP A 739
LYS A 729
 None
 1.47A 4k7aA-2ljfA:
undetectable		 4k7aA-2ljfA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ond CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT

(Mus musculus) 		PF05843
(Suf) 		3 GLU A 259
TRP A 258
LYS A 274
 None
 1.05A 4k7aA-2ondA:
undetectable		 4k7aA-2ondA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Paraburkholderia
phymatum) 		PF13377
(Peripla_BP_3) 		3 GLU A 110
TRP A 341
LYS A 105
 None
 1.49A 4k7aA-2rgyA:
undetectable		 4k7aA-2rgyA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE

(Paraburkholderia
xenovorans) 		PF12697
(Abhydrolase_6) 		3 GLU A 270
TRP A 269
LYS A 262
 None
 1.50A 4k7aA-2ri6A:
undetectable		 4k7aA-2ri6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		3 GLU A 219
TRP A 367
LYS A 224
 None
 1.40A 4k7aA-2vg8A:
undetectable		 4k7aA-2vg8A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		3 GLU A 214
TRP A 298
LYS A 210
 None
DEP  A 473 (-3.7A)
None
 1.08A 4k7aA-3d5eA:
undetectable		 4k7aA-3d5eA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 GLU A1261
TRP A1284
LYS A 705
 None
 1.27A 4k7aA-3ecqA:
undetectable		 4k7aA-3ecqA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exc UNCHARACTERIZED
PROTEIN

(Sulfolobus
solfataricus) 		PF09827
(CRISPR_Cas2) 		3 GLU X  36
TRP X  72
LYS X  23
 None
 1.47A 4k7aA-3excX:
undetectable		 4k7aA-3excX:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpr RHODOCETIN SUBUNIT
GAMMA

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		3 GLU C3029
TRP C3025
LYS C3130
 None
 1.45A 4k7aA-3gprC:
undetectable		 4k7aA-3gprC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		3 GLU A 321
TRP A 319
LYS A 160
 None
 1.44A 4k7aA-3h09A:
undetectable		 4k7aA-3h09A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbz PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13201
(PCMD) 		3 GLU A  28
TRP A 102
LYS A 105
 CA  A   2 ( 3.1A)
CAC  A   5 (-4.7A)
None
 1.03A 4k7aA-3hbzA:
undetectable		 4k7aA-3hbzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		3 GLU A1040
TRP A1037
LYS A1578
 None
 0.56A 4k7aA-3hmjA:
undetectable		 4k7aA-3hmjA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		3 GLU A 131
TRP A 290
LYS A 258
 None
 1.32A 4k7aA-3ma6A:
undetectable		 4k7aA-3ma6A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmw ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		3 GLU A 188
TRP A 187
LYS A   3
 None
 1.42A 4k7aA-3mmwA:
undetectable		 4k7aA-3mmwA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		3 GLU A 796
TRP A 970
LYS A 833
 None
None
SO4  A 998 ( 4.9A)
 1.08A 4k7aA-3opyA:
undetectable		 4k7aA-3opyA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqb PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD

(Salmonella
enterica) 		PF06511
(IpaD)
PF09392
(T3SS_needle_F) 		3 GLU A 237
TRP A 234
LYS A  50
 None
 1.02A 4k7aA-3zqbA:
undetectable		 4k7aA-3zqbA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acz ENDO-ALPHA-MANNOSIDA
SE

(Bacteroides
thetaiotaomicron) 		PF16317
(Glyco_hydro_99) 		3 GLU B 337
TRP B 330
LYS B 107
 None
 1.16A 4k7aA-4aczB:
undetectable		 4k7aA-4aczB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewi NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF02758
(PYRIN) 		3 GLU A  17
TRP A  13
LYS A  19
 None
 1.33A 4k7aA-4ewiA:
undetectable		 4k7aA-4ewiA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE

(Escherichia
coli) 		PF08003
(Methyltransf_9) 		3 GLU A 282
TRP A 109
LYS A 314
 None
 1.09A 4k7aA-4qnxA:
undetectable		 4k7aA-4qnxA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8f VACUOLAR
AMINOPEPTIDASE 1

(Saccharomyces
cerevisiae) 		PF02127
(Peptidase_M18) 		3 GLU A 311
TRP A 332
LYS A 306
 None
 1.35A 4k7aA-4r8fA:
undetectable		 4k7aA-4r8fA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn3 TRIM5/CYCLOPHILIN A
FUSION PROTEIN/T4
LYSOZYME CHIMERA

(Escherichia
virus T4;
Macaca mulatta) 		PF00643
(zf-B_box)
PF00959
(Phage_lysozyme) 		3 GLU A 197
TRP A 196
LYS A 278
 None
 1.11A 4k7aA-4tn3A:
undetectable		 4k7aA-4tn3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utf GLYCOSYL HYDROLASE
FAMILY 71

(Bacteroides
xylanisolvens) 		PF16317
(Glyco_hydro_99) 		3 GLU A 341
TRP A 334
LYS A 108
 None
 0.86A 4k7aA-4utfA:
undetectable		 4k7aA-4utfA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE

(Pseudomonas
putida) 		PF00296
(Bac_luciferase) 		3 GLU A 100
TRP A 191
LYS A  69
 None
PEG  A 403 (-3.7A)
None
 1.44A 4k7aA-4uwmA:
undetectable		 4k7aA-4uwmA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)

(Mycobacterium
avium) 		PF00722
(Glyco_hydro_16) 		3 GLU A 159
TRP A 151
LYS A 185
 None
 1.26A 4k7aA-4xxpA:
undetectable		 4k7aA-4xxpA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 GLU A1261
TRP A1284
LYS A 705
 None
 1.24A 4k7aA-5a55A:
undetectable		 4k7aA-5a55A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 GLU B 341
TRP C 110
LYS B 292
 None
 0.95A 4k7aA-5a8rB:
undetectable		 4k7aA-5a8rB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE

(Homo sapiens) 		PF05118
(Asp_Arg_Hydrox) 		3 GLU A 713
TRP A 594
LYS A 697
 None
 1.38A 4k7aA-5apaA:
undetectable		 4k7aA-5apaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		3 GLU A 241
TRP A 238
LYS A 335
 ACT  A 810 (-3.2A)
None
None
 1.48A 4k7aA-5bv9A:
undetectable		 4k7aA-5bv9A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		3 GLU A 695
TRP A 238
LYS A   4
 None
 1.48A 4k7aA-5bv9A:
undetectable		 4k7aA-5bv9A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gx8 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Streptobacillus
moniliformis) 		PF13416
(SBP_bac_8) 		3 GLU A 198
TRP A 163
LYS A 195
 CA  A 601 (-2.2A)
None
None
 1.25A 4k7aA-5gx8A:
undetectable		 4k7aA-5gx8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbh 30S RIBOSOMAL
PROTEIN ES27

(Pyrococcus
abyssi) 		PF01599
(Ribosomal_S27) 		3 GLU Y  47
TRP Y  38
LYS Y  42
 None
None
G  2 986 ( 4.6A)
 1.39A 4k7aA-5jbhY:
undetectable		 4k7aA-5jbhY:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbh 30S RIBOSOMAL
PROTEIN US7

(Pyrococcus
abyssi) 		PF00177
(Ribosomal_S7) 		3 GLU H 128
TRP H 125
LYS H  34
 None
 1.04A 4k7aA-5jbhH:
undetectable		 4k7aA-5jbhH:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B

(Methanothermococcus
thermolithotrophicus) 		PF02754
(CCG) 		3 GLU B  87
TRP B  56
LYS B 157
 None
 1.35A 4k7aA-5odrB:
undetectable		 4k7aA-5odrB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL

(Aspergillus
fumigatus) 		no annotation 3 GLU A 118
TRP A 237
LYS A 108
 None
 1.38A 4k7aA-5uqrA:
undetectable		 4k7aA-5uqrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1

(Streptococcus
gordonii) 		no annotation 3 GLU A 182
TRP A  16
LYS A 185
 None
 1.32A 4k7aA-5vaeA:
undetectable		 4k7aA-5vaeA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wco NS2

(Salmon isavirus) 		no annotation 3 GLU A 170
TRP A 125
LYS A 164
 None
 1.46A 4k7aA-5wcoA:
undetectable		 4k7aA-5wcoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6n DUFFY BINDING
PROTEIN

(Plasmodium
knowlesi) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		3 GLU A 194
TRP A  27
LYS A 100
 None
None
SO4  A 502 (-2.4A)
 1.48A 4k7aA-5x6nA:
undetectable		 4k7aA-5x6nA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 3 GLU A 766
TRP A 826
LYS A 533
 None
 1.17A 4k7aA-5xiiA:
undetectable		 4k7aA-5xiiA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2

(Homo sapiens) 		no annotation 3 GLU A 356
TRP A 360
LYS A 349
 None
 0.74A 4k7aA-6apjA:
undetectable		 4k7aA-6apjA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgd GLUCOSE/GALACTOSE-BI
NDING LIPOPROTEIN

(Treponema
pallidum) 		no annotation 3 GLU A  97
TRP A 106
LYS A  49
 None
 0.92A 4k7aA-6bgdA:
undetectable		 4k7aA-6bgdA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 3
DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 3 GLU 3 269
TRP A 356
LYS 3 255
 None
 1.37A 4k7aA-6c263:
undetectable		 4k7aA-6c263:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2k FERM, ARHGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		no annotation 3 GLU A 150
TRP A  96
LYS A 145
 None
 1.44A 4k7aA-6d2kA:
undetectable		 4k7aA-6d2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhe -

(-) 		no annotation 3 GLU A  62
TRP A 101
LYS A 136
 None
 1.48A 4k7aA-6fheA:
undetectable		 4k7aA-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 3 GLU A1042
TRP A 912
LYS A1047
 None
 1.42A 4k7aA-6fuyA:
0.4		 4k7aA-6fuyA:
13.60