SIMILAR PATTERNS OF AMINO ACIDS FOR 4K50_I_ACTI507_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE

(Acinetobacter
glutaminasificans) 		PF00710
(Asparaginase) 		3 LYS A  80
PRO A  81
SER A  82
 None
 0.39A 4k50I-1agxA:
0.0		 4k50I-1agxA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b97 RESTRICTION
ENDONUCLEASE ECORV

(Escherichia
coli) 		PF09233
(Endonuc-EcoRV) 		3 LYS A  79
PRO A  80
SER A  81
 None
 0.32A 4k50I-1b97A:
0.0		 4k50I-1b97A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		3 LYS A 145
PRO A 146
SER A 147
 None
 0.40A 4k50I-1f8rA:
0.0		 4k50I-1f8rA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i31 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		3 LYS A 312
PRO A 313
SER A 314
 None
 0.40A 4k50I-1i31A:
0.0		 4k50I-1i31A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lba T7 LYSOZYME

(Escherichia
virus T7) 		PF01510
(Amidase_2) 		3 LYS A  22
PRO A  23
SER A  24
 None
 0.28A 4k50I-1lbaA:
undetectable		 4k50I-1lbaA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		3 LYS A 265
PRO A 266
SER A 267
 None
 0.43A 4k50I-1mnnA:
0.0		 4k50I-1mnnA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4a PUR OPERON REPRESSOR

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF09182
(PuR_N) 		3 LYS A 111
PRO A 112
SER A 113
 None
 0.35A 4k50I-1p4aA:
0.0		 4k50I-1p4aA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 196
PRO A 197
SER A 198
 ATP  A 535 (-2.7A)
None
ATP  A 535 (-3.1A)
 0.44A 4k50I-1s9iA:
0.0		 4k50I-1s9iA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfx CONSERVED
HYPOTHETICAL PROTEIN
AF2008

(Archaeoglobus
fulgidus) 		PF01978
(TrmB) 		3 LYS A  18
PRO A  19
SER A  20
 None
CL  A 501 (-4.0A)
CL  A 501 (-3.2A)
 0.42A 4k50I-1sfxA:
undetectable		 4k50I-1sfxA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 626
PRO A 627
SER A 628
 None
 0.34A 4k50I-1t46A:
undetectable		 4k50I-1t46A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 XYLANASE INHIBITOR
PROTEIN I

(Triticum
aestivum) 		PF00704
(Glyco_hydro_18) 		3 LYS A 108
PRO A 109
SER A 110
 None
 0.36A 4k50I-1ta3A:
0.0		 4k50I-1ta3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		3 LYS A 145
PRO A 146
SER A 147
 None
 0.36A 4k50I-1tdkA:
undetectable		 4k50I-1tdkA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		3 LYS A 133
PRO A 134
SER A 135
 None
 0.43A 4k50I-1ve3A:
undetectable		 4k50I-1ve3A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965

(Mycobacterium
tuberculosis) 		PF01068
(DNA_ligase_A_M)
PF04679
(DNA_ligase_A_C) 		3 LYS A 752
PRO A 753
SER A 754
 None
 0.39A 4k50I-1vs0A:
undetectable		 4k50I-1vs0A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsc HYPOTHETICAL PROTEIN
ST0229

(Sulfurisphaera
tokodaii) 		PF01871
(AMMECR1) 		3 LYS A 216
PRO A 217
SER A 218
 None
 0.32A 4k50I-1wscA:
undetectable		 4k50I-1wscA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE

(Escherichia
virus T4) 		PF11440
(AGT) 		3 LYS A1104
PRO A1105
SER A1106
 None
 0.44A 4k50I-1xv5A:
undetectable		 4k50I-1xv5A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9i INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE-4

(Mus musculus) 		no annotation 3 LYS A  41
PRO A  42
SER A  43
 None
 0.47A 4k50I-2a9iA:
undetectable		 4k50I-2a9iA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az0 B2 PROTEIN

(Flock House
virus) 		PF11473
(B2) 		3 LYS A  62
PRO A  63
SER A  64
 G  C  17 ( 3.1A)
C  C  18 ( 4.3A)
G  C  17 ( 3.8A)
 0.45A 4k50I-2az0A:
undetectable		 4k50I-2az0A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 191
PRO A 192
SER A 193
 None
 0.20A 4k50I-2b1pA:
undetectable		 4k50I-2b1pA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp5 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		3 LYS M 312
PRO M 313
SER M 314
 None
 0.43A 4k50I-2bp5M:
undetectable		 4k50I-2bp5M:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 LYS A 139
PRO A 140
SER A 141
 None
None
ADP  A 500 (-4.4A)
 0.41A 4k50I-2f9gA:
undetectable		 4k50I-2f9gA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ge5 TYPE II RESTRICTION
ENZYME ECORV

(Escherichia
coli) 		PF09233
(Endonuc-EcoRV) 		3 LYS A  79
PRO A  80
SER A  81
 None
 0.46A 4k50I-2ge5A:
undetectable		 4k50I-2ge5A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gyq YCFI, PUTATIVE
STRUCTURAL PROTEIN

(Rhodopseudomonas
palustris) 		PF05974
(DUF892) 		3 LYS A  73
PRO A  74
SER A  75
 None
 0.43A 4k50I-2gyqA:
undetectable		 4k50I-2gyqA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		3 LYS A  42
PRO A  43
SER A  44
 None
 0.49A 4k50I-2hj0A:
undetectable		 4k50I-2hj0A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5c 1,8-CINEOLE SYNTHASE

(Salvia
fruticosa) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 LYS A 181
PRO A 182
SER A 183
 None
 0.35A 4k50I-2j5cA:
0.6		 4k50I-2j5cA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 237
PRO A 238
SER A 239
 None
 0.29A 4k50I-2jgzA:
undetectable		 4k50I-2jgzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nd1 BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF17035
(BET) 		3 LYS A  60
PRO A  61
SER A  62
 None
 0.42A 4k50I-2nd1A:
undetectable		 4k50I-2nd1A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 LYS A  39
PRO A  40
SER A  41
 None
 0.51A 4k50I-2ph5A:
undetectable		 4k50I-2ph5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		3 LYS A 482
PRO A 483
SER A 484
 None
 0.32A 4k50I-2pyxA:
undetectable		 4k50I-2pyxA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyo O-METHYLTRANSFERASE

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 LYS A   9
PRO A  10
SER A  11
 None
 0.35A 4k50I-2qyoA:
undetectable		 4k50I-2qyoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 LYS A 167
PRO A 168
SER A 169
 None
MGD  A1765 ( 4.5A)
None
 0.35A 4k50I-2vpwA:
undetectable		 4k50I-2vpwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 LYS A  68
PRO A  69
SER A  70
 None
 0.33A 4k50I-2x0nA:
undetectable		 4k50I-2x0nA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		3 LYS A  68
PRO A  69
SER A  70
 PE5  A 580 ( 2.9A)
None
PE5  A 580 ( 3.8A)
 0.48A 4k50I-2yeqA:
undetectable		 4k50I-2yeqA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axy PROTEIN HEADING DATE
3A

(Oryza sativa) 		PF01161
(PBP) 		3 LYS A  46
PRO A  47
SER A  48
 None
 0.40A 4k50I-3axyA:
undetectable		 4k50I-3axyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF06325
(PrmA) 		3 LYS A 281
PRO A 282
SER A 283
 None
 0.31A 4k50I-3b3jA:
undetectable		 4k50I-3b3jA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		3 LYS A 653
PRO A 654
SER A 655
 None
 0.41A 4k50I-3d3lA:
undetectable		 4k50I-3d3lA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 LYS A  68
PRO A  69
SER A  70
 None
 0.18A 4k50I-3decA:
undetectable		 4k50I-3decA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr2 EXPORTED
GLUCONOLACTONASE

(Xanthomonas
campestris) 		PF08450
(SGL) 		3 LYS A 155
PRO A 156
SER A 157
 None
 0.22A 4k50I-3dr2A:
undetectable		 4k50I-3dr2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epj TRNA
ISOPENTENYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01715
(IPPT) 		3 LYS A 185
PRO A 186
SER A 187
 None
 0.41A 4k50I-3epjA:
undetectable		 4k50I-3epjA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 181
PRO A 182
SER A 183
 None
None
STU  A   1 (-4.2A)
 0.43A 4k50I-3fmeA:
undetectable		 4k50I-3fmeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7t GROUP 3 ALLERGEN
SMIPP-S YVT004A06

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		3 LYS A  47
PRO A  48
SER A  49
 None
 0.41A 4k50I-3h7tA:
undetectable		 4k50I-3h7tA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		3 LYS A 363
PRO A 364
SER A 365
 None
 0.38A 4k50I-3i09A:
undetectable		 4k50I-3i09A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S35,
MITOCHONDRIAL

(Bos taurus) 		PF00411
(Ribosomal_S11) 		3 LYS k  79
PRO k  80
SER k  81
 None
 0.44A 4k50I-3jd5k:
undetectable		 4k50I-3jd5k:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		3 LYS A 145
PRO A 146
SER A 147
 None
 0.38A 4k50I-3kveA:
undetectable		 4k50I-3kveA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		3 LYS A 709
PRO A 710
SER A 711
 None
 0.29A 4k50I-3la4A:
undetectable		 4k50I-3la4A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le2 SERPIN-ZX

(Arabidopsis
thaliana) 		PF00079
(Serpin) 		3 LYS A 107
PRO A 108
SER A 109
 None
 0.31A 4k50I-3le2A:
undetectable		 4k50I-3le2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU

(Mus musculus;
Rattus
norvegicus) 		PF00610
(DEP)
PF00928
(Adap_comp_sub) 		3 LYS A1312
PRO A1313
SER A1314
 None
 0.51A 4k50I-3ml6A:
undetectable		 4k50I-3ml6A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3w RIBONUCLEASE III

(Campylobacter
jejuni) 		PF14622
(Ribonucleas_3_3) 		3 LYS A 107
PRO A 108
SER A 109
 None
 0.33A 4k50I-3n3wA:
undetectable		 4k50I-3n3wA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2r RIBONUCLEASE III

(Campylobacter
jejuni) 		PF14622
(Ribonucleas_3_3) 		3 LYS B 107
PRO B 108
SER B 109
 None
 0.30A 4k50I-3o2rB:
undetectable		 4k50I-3o2rB:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 LYS A 136
PRO A 137
SER A 138
 None
 0.33A 4k50I-3oz6A:
0.3		 4k50I-3oz6A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		3 LYS B 735
PRO B 736
SER B 737
 None
 0.45A 4k50I-3p8cB:
2.6		 4k50I-3p8cB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qok PUTATIVE CHITINASE
II

(Klebsiella
pneumoniae) 		PF00704
(Glyco_hydro_18) 		3 LYS A 265
PRO A 266
SER A 267
 None
 0.41A 4k50I-3qokA:
undetectable		 4k50I-3qokA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		3 LYS A 159
PRO A 160
SER A 161
 None
 0.44A 4k50I-3t57A:
2.3		 4k50I-3t57A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 LYS A 471
PRO A 472
SER A 473
 None
 0.37A 4k50I-3thzA:
undetectable		 4k50I-3thzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137

(Staphylococcus
aureus) 		PF13379
(NMT1_2) 		3 LYS A 287
PRO A 288
SER A 289
 None
 0.26A 4k50I-3un6A:
undetectable		 4k50I-3un6A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvj BETA-GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00722
(Glyco_hydro_16) 		3 LYS A  65
PRO A  66
SER A  67
 None
 0.49A 4k50I-3wvjA:
undetectable		 4k50I-3wvjA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz3 TRAM PROTEIN

(Plasmid R64) 		PF11393
(T4BSS_DotI_IcmL) 		3 LYS A 212
PRO A 213
SER A 214
 SO4  A 301 ( 4.5A)
None
None
 0.40A 4k50I-3wz3A:
1.6		 4k50I-3wz3A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Leishmania
major) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 LYS A 268
PRO A 269
SER A 270
 None
 0.47A 4k50I-4cgnA:
undetectable		 4k50I-4cgnA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ct3 ORF30/ORF32

(Staphylococcus
virus K) 		PF05257
(CHAP) 		3 LYS A  94
PRO A  95
SER A  96
 MMC  A1172 ( 4.3A)
None
None
 0.48A 4k50I-4ct3A:
undetectable		 4k50I-4ct3A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dox COAT PROTEIN

(Papaya mosaic
virus) 		PF00286
(Flexi_CP) 		3 LYS A 133
PRO A 134
SER A 135
 None
 0.49A 4k50I-4doxA:
undetectable		 4k50I-4doxA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dth VGRG PROTEIN

(Vibrio cholerae) 		PF16671
(ACD) 		3 LYS A 270
PRO A 271
SER A 272
 None
 0.40A 4k50I-4dthA:
undetectable		 4k50I-4dthA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0q RESTRICTION
ENDONUCLEASE

(Mycobacterium
sp. JLS) 		PF04471
(Mrr_cat) 		3 LYS A 119
PRO A 120
SER A 121
 None
 0.40A 4k50I-4f0qA:
undetectable		 4k50I-4f0qA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		3 LYS A1068
PRO A1069
SER A1070
 None
 0.32A 4k50I-4fgvA:
0.6		 4k50I-4fgvA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		3 LYS B 709
PRO B 710
SER B 711
 None
 0.23A 4k50I-4g7eB:
undetectable		 4k50I-4g7eB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9q 4-CARBOXYMUCONOLACTO
NE DECARBOXYLASE

(Sinorhizobium
meliloti) 		PF02627
(CMD) 		3 LYS A  84
PRO A  85
SER A  86
 None
 0.29A 4k50I-4g9qA:
1.3		 4k50I-4g9qA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		3 LYS A 469
PRO A 470
SER A 471
 None
 0.26A 4k50I-4hwvA:
undetectable		 4k50I-4hwvA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1n UBIQUITIN
CONJUGATING ENZYME
UBC9

(Plasmodium
falciparum) 		PF00179
(UQ_con) 		3 LYS A 104
PRO A 105
SER A 106
 None
 0.37A 4k50I-4m1nA:
undetectable		 4k50I-4m1nA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m29 BETA-XYLOSIDASE

(Caulobacter
vibrioides) 		PF01229
(Glyco_hydro_39) 		3 LYS A 348
PRO A 349
SER A 350
 None
 0.44A 4k50I-4m29A:
undetectable		 4k50I-4m29A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5y FAB 5J8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS H  60
PRO H  61
SER H  62
 None
 0.50A 4k50I-4m5yH:
undetectable		 4k50I-4m5yH:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		3 LYS A 257
PRO A 258
SER A 259
 None
 0.37A 4k50I-4ng3A:
undetectable		 4k50I-4ng3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 LYS A 189
PRO A 190
SER A 191
 None
SO4  A 612 ( 4.1A)
None
 0.48A 4k50I-4o4xA:
undetectable		 4k50I-4o4xA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		3 LYS A 221
PRO A 222
SER A 223
 None
 0.31A 4k50I-4perA:
undetectable		 4k50I-4perA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF17033
(Peptidase_M99)
PF17129
(Peptidase_M99_C)
PF17130
(Peptidase_M99_m) 		3 LYS A 118
PRO A 119
SER A 120
 None
 0.43A 4k50I-4q6pA:
undetectable		 4k50I-4q6pA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 LYS A 305
PRO A 306
SER A 307
 None
 0.40A 4k50I-4r16A:
undetectable		 4k50I-4r16A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1j GU4 NUCLEIC-BINDING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF01588
(tRNA_bind) 		3 LYS A   5
PRO A   6
SER A   7
 None
 0.41A 4k50I-4r1jA:
undetectable		 4k50I-4r1jA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME

(Bacillus
licheniformis) 		PF01547
(SBP_bac_1) 		3 LYS A 251
PRO A 252
SER A 253
 None
FRU  A 504 ( 4.6A)
None
 0.36A 4k50I-4rk9A:
undetectable		 4k50I-4rk9A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		3 LYS B 152
PRO B 153
SER B 154
 None
 0.43A 4k50I-4tyhB:
0.8		 4k50I-4tyhB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uul L-LACTATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LYS A 120
PRO A 121
SER A 122
 None
 0.31A 4k50I-4uulA:
undetectable		 4k50I-4uulA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy4 SPINDLIN-4

(Homo sapiens) 		PF02513
(Spin-Ssty) 		3 LYS A 216
PRO A 217
SER A 218
 None
 0.37A 4k50I-4uy4A:
undetectable		 4k50I-4uy4A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk3 BEPE PROTEIN

(Bartonella
henselae) 		no annotation 3 LYS A 187
PRO A 188
SER A 189
 None
 0.47A 4k50I-4yk3A:
undetectable		 4k50I-4yk3A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		3 LYS A 717
PRO A 718
SER A 719
 None
 0.45A 4k50I-4zm6A:
undetectable		 4k50I-4zm6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		3 LYS A 151
PRO A 152
SER A 153
 None
None
MG  A 402 (-4.5A)
 0.30A 4k50I-5awmA:
undetectable		 4k50I-5awmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 LYS A 191
PRO A 192
SER A 193
 None
 0.37A 4k50I-5ci6A:
undetectable		 4k50I-5ci6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4e INTERLEUKIN-4
RECEPTOR SUBUNIT
ALPHA

(Homo sapiens) 		PF09238
(IL4Ra_N) 		3 LYS B  91
PRO B  92
SER B  93
 None
 0.47A 4k50I-5e4eB:
undetectable		 4k50I-5e4eB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewn STRUCTURAL PROTEIN

(Mamastrovirus 1) 		PF03115
(Astro_capsid_N) 		3 LYS A 195
PRO A 196
SER A 197
 None
 0.46A 4k50I-5ewnA:
undetectable		 4k50I-5ewnA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gve DNA TOPOISOMERASE
3-BETA-1

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 LYS A  10
PRO A  11
SER A  12
 None
 0.30A 4k50I-5gveA:
undetectable		 4k50I-5gveA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 LYS A 546
PRO A 547
SER A 548
 None
 0.40A 4k50I-5ikrA:
undetectable		 4k50I-5ikrA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		3 LYS A 253
PRO A 254
SER A 255
 None
 0.31A 4k50I-5j84A:
0.9		 4k50I-5j84A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana) 		PF03321
(GH3) 		3 LYS A 354
PRO A 355
SER A 356
 None
 0.28A 4k50I-5kodA:
undetectable		 4k50I-5kodA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 LYS A 328
PRO A 329
SER A 330
 None
 0.49A 4k50I-5lnqA:
undetectable		 4k50I-5lnqA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6m E3 UBIQUITIN-PROTEIN
LIGASE XIAP

(Homo sapiens) 		PF00653
(BIR) 		3 LYS A 311
PRO A 312
SER A 313
 None
 0.30A 4k50I-5m6mA:
undetectable		 4k50I-5m6mA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nph HEAVY CHAIN OF FAB
FRAGMENT DERIVED
FROM
NON-NEUTRALIZING
ANTIBODY DAO5

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS H  52
PRO H  53
SER H  54
 None
 0.36A 4k50I-5nphH:
undetectable		 4k50I-5nphH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npi SINGLE CHAIN
VARIABLE FRAGMENT OF
THE NON-NEUTRALIZING
ANTIBODY DAO5

(Mus musculus) 		PF07686
(V-set) 		3 LYS A  52
PRO A  53
SER A  54
 None
 0.34A 4k50I-5npiA:
undetectable		 4k50I-5npiA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU

(Escherichia
coli) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 LYS A 314
PRO A 315
SER A 316
 None
 0.49A 4k50I-5txvA:
undetectable		 4k50I-5txvA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuj ALKZ

(Streptomyces
sahachiroi) 		PF06224
(HTH_42) 		3 LYS A 102
PRO A 103
SER A 104
 None
 0.27A 4k50I-5uujA:
undetectable		 4k50I-5uujA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrk AP-2 COMPLEX SUBUNIT
MU

(Rattus
norvegicus) 		no annotation 3 LYS A 312
PRO A 313
SER A 314
 None
 0.44A 4k50I-5wrkA:
undetectable		 4k50I-5wrkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t PROTEIN L29

(Spinacia
oleracea) 		PF00831
(Ribosomal_L29) 		3 LYS Z 101
PRO Z 102
SER Z 103
 G  A  95 ( 3.5A)
A  A  94 ( 3.9A)
A  A  94 ( 3.0A)
 0.50A 4k50I-5x8tZ:
undetectable		 4k50I-5x8tZ:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2g L-AMINO ACID OXIDASE

(Naja atra) 		no annotation 3 LYS A 164
PRO A 165
SER A 166
 NAG  A 603 (-2.8A)
None
None
 0.42A 4k50I-5z2gA:
undetectable		 4k50I-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z81 HEAT SHOCK PROTEIN
15

(Vibrio cholerae) 		no annotation 3 LYS A  45
PRO A  46
SER A  47
 None
 0.39A 4k50I-5z81A:
undetectable		 4k50I-5z81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo sapiens) 		no annotation 3 LYS A 280
PRO A 281
SER A 282
 None
 0.21A 4k50I-6d2lA:
undetectable		 4k50I-6d2lA:
undetectable