SIMILAR PATTERNS OF AMINO ACIDS FOR 4K50_E_ACTE501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ksx	REPLICATION PROTEIN E1 (Bovine papillomavirus)	PF00519 (PPV_E1_C)	4	CYH A 215 THR A 239 PHE A 237 LYS A 241	None	1.31A	4k50E-1ksxA: 0.0	4k50E-1ksxA: 15.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1tp7	GENOME POLYPROTEIN (Rhinovirus A)	PF00680 (RdRP_1)	4	CYH A 212 THR A 216 PHE A 217 LYS A 220	SO4 A 470 (-4.5A) SO4 A 470 (-3.7A) SO4 A 470 (-4.5A) SO4 A 470 (-3.1A)	0.31A	4k50E-1tp7A: 55.5	4k50E-1tp7A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1xr6	GENOME POLYPROTEIN (Rhinovirus A)	PF00680 (RdRP_1)	4	CYH A 212 THR A 216 PHE A 217 LYS A 220	None	0.32A	4k50E-1xr6A: 55.6	4k50E-1xr6A: 85.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2alb	PROTEIN DISULFIDE-ISOMERASE A3 (Homo sapiens)	PF00085 (Thioredoxin)	4	CYH A 68 THR A 78 PHE A 28 LYS A 80	None	1.40A	4k50E-2albA: 0.0	4k50E-2albA: 13.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3n6n	RNA-DEPENDENT RNA POLYMERASE (Enterovirus A)	PF00680 (RdRP_1)	4	CYH A 212 THR A 216 PHE A 217 LYS A 220	None	0.35A	4k50E-3n6nA: 50.2	4k50E-3n6nA: 54.86

[["4K50_E_ACTE501_0","1ksx","Bovine papillomavirus","REPLICATION PROTEIN E1","PF00519(PPV_E1_C)",4,"CYH A 215;THR A 239;PHE A 237;LYS A 241","None","1.31A","4k50E-1ksxA:0.0","4k50E-1ksxA:15.28"],["4K50_E_ACTE501_0","1tp7","Rhinovirus A","GENOME POLYPROTEIN","PF00680(RdRP_1)",4,"CYH A 212;THR A 216;PHE A 217;LYS A 220","SO4 A 470 (-4.5A);SO4 A 470 (-3.7A);SO4 A 470 (-4.5A);SO4 A 470 (-3.1A)","0.31A","4k50E-1tp7A:55.5","4k50E-1tp7A:100.00"],["4K50_E_ACTE501_0","1xr6","Rhinovirus A","GENOME POLYPROTEIN","PF00680(RdRP_1)",4,"CYH A 212;THR A 216;PHE A 217;LYS A 220","None","0.32A","4k50E-1xr6A:55.6","4k50E-1xr6A:85.22"],["4K50_E_ACTE501_0","2alb","Homo sapiens","PROTEIN DISULFIDE-ISOMERASE A3","PF00085(Thioredoxin)",4,"CYH A  68;THR A  78;PHE A  28;LYS A  80","None","1.40A","4k50E-2albA:0.0","4k50E-2albA:13.86"],["4K50_E_ACTE501_0","3n6n","Enterovirus A","RNA-DEPENDENT RNA POLYMERASE","PF00680(RdRP_1)",4,"CYH A 212;THR A 216;PHE A 217;LYS A 220","None","0.35A","4k50E-3n6nA:50.2","4k50E-3n6nA:54.86"]]