SIMILAR PATTERNS OF AMINO ACIDS FOR 4K50_B_ACTB701_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bl5 | ISOCITRATEDEHYDROGENASE (Escherichiacoli) |
PF00180(Iso_dh) | 3 | HIS A 366GLY A 329ILE A 328 | None | 0.62A | 4k50A-1bl5A:undetectable | 4k50A-1bl5A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1crl | LIPASE (Diutina rugosa) |
PF00135(COesterase) | 3 | HIS A 368GLY A 252ILE A 253 | None | 0.61A | 4k50A-1crlA:0.0 | 4k50A-1crlA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dgj | ALDEHYDEOXIDOREDUCTASE (Desulfovibriodesulfuricans) |
PF00111(Fer2)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2) | 3 | HIS A 242GLY A 224ILE A 225 | None | 0.58A | 4k50A-1dgjA:0.0 | 4k50A-1dgjA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dqw | OROTIDINE5'-PHOSPHATEDECARBOXYLASE (Saccharomycescerevisiae) |
PF00215(OMPdecase) | 3 | HIS A 13GLY A 181ILE A 180 | None | 0.64A | 4k50A-1dqwA:0.0 | 4k50A-1dqwA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nnw | HYPOTHETICAL PROTEIN (Pyrococcusfuriosus) |
no annotation | 3 | HIS A 98GLY A 250ILE A 245 | None | 0.51A | 4k50A-1nnwA:0.0 | 4k50A-1nnwA:21.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1rdr | POLIOVIRUS 3DPOLYMERASE (Enterovirus C) |
PF00680(RdRP_1) | 3 | HIS A 199GLY A 292ILE A 295 | None | 0.48A | 4k50A-1rdrA:36.7 | 4k50A-1rdrA:56.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sie | POLYOMAVIRUS COATPROTEIN VP1 (Mus musculuspolyomavirus 1) |
PF00718(Polyoma_coat) | 3 | HIS A 163GLY A 287ILE A 285 | None | 0.51A | 4k50A-1sieA:undetectable | 4k50A-1sieA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vbr | ENDO-1,4-BETA-XYLANASE B (Thermotogamaritima) |
PF00331(Glyco_hydro_10) | 3 | HIS A 596GLY A 720ILE A 686 | None | 0.54A | 4k50A-1vbrA:0.0 | 4k50A-1vbrA:20.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xr5 | GENOME POLYPROTEIN (Rhinovirus B) |
PF00680(RdRP_1) | 3 | HIS A 199GLY A 291ILE A 294 | None | 0.41A | 4k50A-1xr5A:51.8 | 4k50A-1xr5A:55.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xr6 | GENOME POLYPROTEIN (Rhinovirus A) |
PF00680(RdRP_1) | 3 | HIS A 199GLY A 291ILE A 294 | None | 0.51A | 4k50A-1xr6A:55.5 | 4k50A-1xr6A:85.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yya | TRIOSEPHOSPHATEISOMERASE (Thermusthermophilus) |
PF00121(TIM) | 3 | HIS A 94GLY A 211ILE A 171 | NonePO4 A2004 ( 3.9A)PO4 A2004 (-4.4A) | 0.64A | 4k50A-1yyaA:undetectable | 4k50A-1yyaA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b24 | NAPHTHALENEDIOXYGENASE LARGESUBUNIT (Rhodococcus sp.NCIMB 12038) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 3 | HIS A 295GLY A 240ILE A 254 | IND A 503 (-3.5A)NoneNone | 0.62A | 4k50A-2b24A:undetectable | 4k50A-2b24A:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bdv | PHAGE-RELATEDCONSERVEDHYPOTHETICALPROTEIN, BB2244 (Bordetellabronchiseptica) |
PF02586(SRAP) | 3 | HIS A 82GLY A 91ILE A 90 | None | 0.56A | 4k50A-2bdvA:undetectable | 4k50A-2bdvA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c81 | GLUTAMINE-2-DEOXY-SCYLLO-INOSOSEAMINOTRANSFERASE (Bacilluscirculans) |
PF01041(DegT_DnrJ_EryC1) | 3 | HIS A 168GLY A 200ILE A 201 | None | 0.56A | 4k50A-2c81A:undetectable | 4k50A-2c81A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cb5 | PROTEIN (BLEOMYCINHYDROLASE) (Homo sapiens) |
PF03051(Peptidase_C1_2) | 3 | HIS A 257GLY A 246ILE A 248 | None | 0.53A | 4k50A-2cb5A:undetectable | 4k50A-2cb5A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cn1 | CYTOSOLIC5'-NUCLEOTIDASE III (Homo sapiens) |
PF05822(UMPH-1) | 3 | HIS A 107GLY A 155ILE A 156 | None | 0.53A | 4k50A-2cn1A:undetectable | 4k50A-2cn1A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1g | ACID PHOSPHATASE (Francisellatularensis) |
PF04185(Phosphoesterase) | 3 | HIS A 109GLY A 407ILE A 206 | None | 0.63A | 4k50A-2d1gA:undetectable | 4k50A-2d1gA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ett | SORTING NEXIN-22 (Homo sapiens) |
PF00787(PX) | 3 | HIS A 59GLY A 97ILE A 98 | None | 0.64A | 4k50A-2ettA:undetectable | 4k50A-2ettA:13.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gju | 252AA LONGHYPOTHETICAL PROTEIN (Pyrococcushorikoshii) |
no annotation | 3 | HIS A 98GLY A 250ILE A 245 | None | 0.58A | 4k50A-2gjuA:undetectable | 4k50A-2gjuA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iaf | HYPOTHETICAL PROTEINSDHL (Legionellapneumophila) |
PF03315(SDH_beta) | 3 | HIS A 111GLY A 136ILE A 135 | None | 0.62A | 4k50A-2iafA:undetectable | 4k50A-2iafA:16.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ijd | PICORNAIN 3C,RNA-DIRECTED RNAPOLYMERASE (Enterovirus C) |
PF00548(Peptidase_C3)PF00680(RdRP_1) | 3 | HIS 1 382GLY 1 475ILE 1 478 | None | 0.28A | 4k50A-2ijd1:51.2 | 4k50A-2ijd1:41.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jf7 | STRICTOSIDINE-O-BETA-D-GLUCOSIDASE (Rauvolfiaserpentina) |
PF00232(Glyco_hydro_1) | 3 | HIS A 442GLY A 482ILE A 483 | None | 0.57A | 4k50A-2jf7A:undetectable | 4k50A-2jf7A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jjm | GLYCOSYLTRANSFERASE, GROUP 1FAMILY PROTEIN (Bacillusanthracis) |
PF00534(Glycos_transf_1)PF13439(Glyco_transf_4) | 3 | HIS A 93GLY A 24ILE A 7 | None | 0.60A | 4k50A-2jjmA:undetectable | 4k50A-2jjmA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nrk | HYPOTHETICAL PROTEINGRPB (Enterococcusfaecalis) |
PF04229(GrpB) | 3 | HIS A 101GLY A 38ILE A 37 | None | 0.59A | 4k50A-2nrkA:undetectable | 4k50A-2nrkA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ond | CLEAVAGE STIMULATIONFACTOR 77 KDASUBUNIT (Mus musculus) |
PF05843(Suf) | 3 | HIS A 360GLY A 394ILE A 397 | None | 0.53A | 4k50A-2ondA:undetectable | 4k50A-2ondA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ooe | CLEAVAGE STIMULATIONFACTOR 77 KDASUBUNIT (Mus musculus) |
PF05843(Suf) | 3 | HIS A 360GLY A 394ILE A 397 | None | 0.43A | 4k50A-2ooeA:1.1 | 4k50A-2ooeA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] LARGE CHAIN (Azospirillumbrasilense) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 3 | HIS A 58GLY A 106ILE A 132 | None | 0.60A | 4k50A-2vdcA:undetectable | 4k50A-2vdcA:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vwb | PUTATIVEO-SIALOGLYCOPROTEINENDOPEPTIDASE (Methanocaldococcusjannaschii) |
PF00814(Peptidase_M22)PF01163(RIO1) | 3 | HIS A 106GLY A 286ILE A 289 | ANP A1531 (-3.4A)NoneNone | 0.56A | 4k50A-2vwbA:undetectable | 4k50A-2vwbA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3g | TWO COMPONENT SENSORHISTIDINE KINASEDEVS (GAF FAMILYPROTEIN) (Mycobacteriumtuberculosis) |
PF13185(GAF_2) | 3 | HIS A 89GLY A 122ILE A 125 | None | 0.33A | 4k50A-2w3gA:undetectable | 4k50A-2w3gA:15.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wj9 | INTERGENIC-REGIONPROTEIN (Escherichiacoli) |
PF03230(Antirestrict) | 3 | HIS A 135GLY A 41ILE A 43 | None | 0.56A | 4k50A-2wj9A:undetectable | 4k50A-2wj9A:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yoc | PULLULANASE (Klebsiellaoxytoca) |
PF02922(CBM_48)PF03714(PUD)PF11852(DUF3372) | 3 | HIS A 767GLY A 805ILE A 798 | None | 0.59A | 4k50A-2yocA:undetectable | 4k50A-2yocA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3blx | ISOCITRATEDEHYDROGENASE [NAD]SUBUNIT 2 (Saccharomycescerevisiae) |
PF00180(Iso_dh) | 3 | HIS B 308GLY B 271ILE B 270 | None | 0.51A | 4k50A-3blxB:undetectable | 4k50A-3blxB:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3enh | UNCHARACTERIZEDPROTEIN MJ0187 (Methanocaldococcusjannaschii) |
PF08617(CGI-121) | 3 | HIS C 40GLY C 68ILE C 142 | None | 0.49A | 4k50A-3enhC:undetectable | 4k50A-3enhC:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f13 | PUTATIVE NUDIXHYDROLASE FAMILYMEMBER (Chromobacteriumviolaceum) |
PF00293(NUDIX) | 3 | HIS A 85GLY A 121ILE A 124 | None | 0.58A | 4k50A-3f13A:undetectable | 4k50A-3f13A:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdn | R-OXYNITRILE LYASEISOENZYME 1 (Prunus dulcis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 3 | HIS A 7GLY A 104ILE A 108 | None | 0.60A | 4k50A-3gdnA:undetectable | 4k50A-3gdnA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hid | ADENYLOSUCCINATESYNTHETASE (Yersinia pestis) |
PF00709(Adenylsucc_synt) | 3 | HIS A 169GLY A 146ILE A 165 | None | 0.54A | 4k50A-3hidA:undetectable | 4k50A-3hidA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ite | SIDN SIDEROPHORESYNTHETASE (Epichloefestucae) |
PF00501(AMP-binding) | 3 | HIS A 270GLY A 207ILE A 206 | None | 0.61A | 4k50A-3iteA:undetectable | 4k50A-3iteA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ja7 | PORTAL PROTEIN GP20 (Escherichiavirus T4) |
PF07230(Peptidase_S80) | 3 | HIS A 136GLY A 170ILE A 171 | None | 0.58A | 4k50A-3ja7A:undetectable | 4k50A-3ja7A:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0r | RESPONSE REGULATOR (Caulobactervibrioides) |
PF00072(Response_reg) | 3 | HIS A 165GLY A 252ILE A 251 | None | 0.60A | 4k50A-3n0rA:undetectable | 4k50A-3n0rA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pei | CYTOSOLAMINOPEPTIDASE (Francisellatularensis) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 3 | HIS A 472GLY A 159ILE A 162 | None | 0.53A | 4k50A-3peiA:undetectable | 4k50A-3peiA:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ram | HMRA PROTEIN (Staphylococcusaureus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 3 | HIS A 330GLY A 313ILE A 165 | GOL A 513 (-4.1A)GOL A 512 ( 4.4A)None | 0.48A | 4k50A-3ramA:undetectable | 4k50A-3ramA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3snx | PUTATIVE SUSD-LIKECARBOHYDRATE BINDINGPROTEIN (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 3 | HIS A 156GLY A 418ILE A 419 | None | 0.60A | 4k50A-3snxA:undetectable | 4k50A-3snxA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t7b | ACETYLGLUTAMATEKINASE (Yersinia pestis) |
PF00696(AA_kinase) | 3 | HIS A 41GLY A 100ILE A 143 | None | 0.60A | 4k50A-3t7bA:undetectable | 4k50A-3t7bA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vg8 | HYPOTHETICAL PROTEINTTHB210 (Thermusthermophilus) |
no annotation | 3 | HIS G 87GLY G 17ILE G 15 | None | 0.59A | 4k50A-3vg8G:undetectable | 4k50A-3vg8G:14.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vkg | DYNEIN HEAVY CHAIN,CYTOPLASMIC (Dictyosteliumdiscoideum) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 3 | HIS A3223GLY A3590ILE A3626 | None | 0.64A | 4k50A-3vkgA:undetectable | 4k50A-3vkgA:9.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w04 | DWARF 88 ESTERASE (Oryza sativa) |
PF12697(Abhydrolase_6) | 3 | HIS A 300GLY A 171ILE A 170 | None | 0.64A | 4k50A-3w04A:undetectable | 4k50A-3w04A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wla | OXIDIZED POLYVINYLALCOHOL HYDROLASE (Sphingopyxissp. 113P3) |
no annotation | 3 | HIS A 279GLY A 49ILE A 155 | SO4 A 901 ( 4.4A)SO4 A 901 ( 3.7A)None | 0.64A | 4k50A-3wlaA:undetectable | 4k50A-3wlaA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wla | OXIDIZED POLYVINYLALCOHOL HYDROLASE (Sphingopyxissp. 113P3) |
no annotation | 3 | HIS A 279GLY A 158ILE A 155 | SO4 A 901 ( 4.4A)NoneNone | 0.59A | 4k50A-3wlaA:undetectable | 4k50A-3wlaA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wla | OXIDIZED POLYVINYLALCOHOL HYDROLASE (Sphingopyxissp. 113P3) |
no annotation | 3 | HIS A 279GLY A 159ILE A 155 | SO4 A 901 ( 4.4A)NoneNone | 0.56A | 4k50A-3wlaA:undetectable | 4k50A-3wlaA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwe | OXIDIZED POLYVINYLALCOHOL HYDROLASE (Pseudomonas sp.VM15C) |
no annotation | 3 | HIS A 298GLY A 174ILE A 171 | None | 0.60A | 4k50A-3wweA:undetectable | 4k50A-3wweA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwe | OXIDIZED POLYVINYLALCOHOL HYDROLASE (Pseudomonas sp.VM15C) |
no annotation | 3 | HIS A 298GLY A 175ILE A 171 | None | 0.52A | 4k50A-3wweA:undetectable | 4k50A-3wweA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zeu | PROBABLE TRNATHREONYLCARBAMOYLADENOSINE BIOSYNTHESISPROTEIN GCP (Salmonellaenterica) |
PF00814(Peptidase_M22) | 3 | HIS B 111GLY B 302ILE B 305 | ZN B1339 ( 3.2A)NoneNone | 0.60A | 4k50A-3zeuB:undetectable | 4k50A-3zeuB:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b56 | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 1 (Mus musculus) |
PF01033(Somatomedin_B)PF01223(Endonuclease_NS)PF01663(Phosphodiest) | 3 | HIS A 811GLY A 786ILE A 876 | NoneNAG A2001 ( 4.9A)None | 0.54A | 4k50A-4b56A:undetectable | 4k50A-4b56A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dia | 2-PYRONE-4,6-DICARBAXYLATE HYDROLASE (Sphingomonaspaucimobilis) |
PF04909(Amidohydro_2) | 3 | HIS A 152GLY A 99ILE A 100 | None | 0.61A | 4k50A-4diaA:undetectable | 4k50A-4diaA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dxw | ION TRANSPORTPROTEIN (alphaproteobacteriumHIMB114) |
PF00520(Ion_trans) | 3 | HIS A 45GLY A 30ILE A 29 | None | 0.61A | 4k50A-4dxwA:undetectable | 4k50A-4dxwA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ege | DIPEPTIDASE PEPE (Mycobacteriumulcerans) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 3 | HIS A 166GLY A 232ILE A 162 | None | 0.62A | 4k50A-4egeA:undetectable | 4k50A-4egeA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g56 | MGC81050 PROTEIN (Xenopus laevis) |
PF00400(WD40) | 3 | HIS B 244GLY B 250ILE B 248 | None | 0.63A | 4k50A-4g56B:undetectable | 4k50A-4g56B:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6m | ACTIN-LIKE PROTEINARP9ACTIN-LIKE PROTEINARP9 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF00022(Actin)PF07529(HSA) | 3 | HIS C 637GLY B 431ILE B 434 | None | 0.59A | 4k50A-4i6mC:undetectable | 4k50A-4i6mC:12.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iqg | SHORT-CHAINDEHYDROGENASE/REDUCTASE SDR (Polaromonas sp.JS666) |
no annotation | 3 | HIS C 195GLY C 188ILE C 189 | NAP C 304 (-3.9A)NAP C 304 (-4.8A)NAP C 304 ( 4.7A) | 0.64A | 4k50A-4iqgC:undetectable | 4k50A-4iqgC:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgc | BILE ACID-COENZYME ALIGASE ([Clostridium]scindens) |
PF00501(AMP-binding) | 3 | HIS A 294GLY A 333ILE A 316 | None | 0.60A | 4k50A-4lgcA:undetectable | 4k50A-4lgcA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mad | BETA-GALACTOSIDASE (Bacilluscirculans) |
PF01301(Glyco_hydro_35) | 3 | HIS A 565GLY A 406ILE A 417 | None | 0.63A | 4k50A-4madA:undetectable | 4k50A-4madA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ofw | PROTEIN DJ-1 HOMOLOGD (Arabidopsisthaliana) |
PF01965(DJ-1_PfpI) | 3 | HIS A 371GLY A 282ILE A 312 | None | 0.57A | 4k50A-4ofwA:undetectable | 4k50A-4ofwA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qpm | MITOTIC CHECKPOINTSERINE/THREONINE-PROTEIN KINASE BUB1 (Homo sapiens) |
PF00069(Pkinase) | 3 | HIS A1024GLY A 892ILE A 895 | None | 0.64A | 4k50A-4qpmA:undetectable | 4k50A-4qpmA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rku | CHLOROPHYLL A-BBINDING PROTEIN 6A,CHLOROPLASTIC (Pisum sativum) |
PF00504(Chloroa_b-bind) | 3 | HIS 1 178GLY 1 57ILE 1 182 | NoneCLA 11004 (-4.5A)CLA 11007 (-4.4A) | 0.63A | 4k50A-4rku1:undetectable | 4k50A-4rku1:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvs | PROBABLE QUINONEREDUCTASE QOR(NADPH:QUINONEREDUCTASE)(ZETA-CRYSTALLINHOMOLOG PROTEIN) (Mycobacteriumtuberculosis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | HIS A 313GLY A 61ILE A 60 | None | 0.64A | 4k50A-4rvsA:undetectable | 4k50A-4rvsA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjs | RSA4 (Chaetomiumthermophilum) |
PF00400(WD40) | 3 | HIS A 88GLY A 46ILE A 42 | None | 0.59A | 4k50A-4wjsA:undetectable | 4k50A-4wjsA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wky | BETA-KETOACYLSYNTHASE (Streptomycesalbus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 3 | HIS A 310GLY A 426ILE A 440 | None | 0.59A | 4k50A-4wkyA:undetectable | 4k50A-4wkyA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y90 | TRIOSEPHOSPHATEISOMERASE (Deinococcusradiodurans) |
PF00121(TIM) | 3 | HIS A 96GLY A 208ILE A 169 | CA A 305 (-4.3A)SO4 A 301 ( 3.9A)SO4 A 301 (-4.8A) | 0.64A | 4k50A-4y90A:undetectable | 4k50A-4y90A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y96 | TRIOSEPHOSPHATEISOMERASE (Gemmataobscuriglobus) |
PF00121(TIM) | 3 | HIS A 99GLY A 216ILE A 176 | NA A 301 (-4.3A)PO4 A 303 ( 4.2A)PO4 A 303 (-4.8A) | 0.62A | 4k50A-4y96A:undetectable | 4k50A-4y96A:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yu4 | HEMOGLOBIN (Helogaleparvula) |
PF00042(Globin) | 3 | HIS A 113GLY A 18ILE A 17 | None | 0.64A | 4k50A-4yu4A:undetectable | 4k50A-4yu4A:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yxt | POLYKETIDEBIOSYNTHESIS3-HYDROXY-3-METHYLGLUTARYL-ACP SYNTHASEPKSG (Bacillussubtilis) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 3 | HIS A 261GLY A 275ILE A 276 | None | 0.64A | 4k50A-4yxtA:undetectable | 4k50A-4yxtA:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z6k | ALCOHOLDEHYDROGENASE (Moraxella sp.TAE123) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | HIS A 76GLY A 132ILE A 133 | None | 0.60A | 4k50A-4z6kA:undetectable | 4k50A-4z6kA:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zoh | PUTATIVEOXIDOREDUCTASEMOLYBDOPTERIN-BINDING SUBUNIT (Sulfurisphaeratokodaii) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 3 | HIS A 663GLY A 418ILE A 489 | None | 0.56A | 4k50A-4zohA:undetectable | 4k50A-4zohA:24.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4zpd | RNA-DIRECTED RNAPOLYMERASE (Enterovirus B) |
PF00680(RdRP_1) | 3 | HIS A 199GLY A 293ILE A 296 | None | 0.28A | 4k50A-4zpdA:52.5 | 4k50A-4zpdA:57.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a2g | CARBOXYLIC ESTERHYDROLASE (Hungatellahathewayi) |
PF00135(COesterase) | 3 | HIS A 145GLY A 202ILE A 111 | None | 0.43A | 4k50A-5a2gA:undetectable | 4k50A-5a2gA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5anb | ELONGATION FACTOR TUGTP-BINDINGDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF14492(EFG_II) | 3 | HIS K 353GLY K 244ILE K 351 | None | 0.60A | 4k50A-5anbK:undetectable | 4k50A-5anbK:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5auo | ATPASE INVOLVED INCHROMOSOMEPARTITIONING,PARA/MIND FAMILY,MRP HOMOLOG (Thermococcuskodakarensis) |
PF10609(ParA) | 3 | HIS B 59GLY B 107ILE B 110 | None | 0.58A | 4k50A-5auoB:undetectable | 4k50A-5auoB:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5av7 | LECTIN (Calystegiasepium) |
PF01419(Jacalin) | 3 | HIS A 111GLY A 78ILE A 77 | None | 0.62A | 4k50A-5av7A:undetectable | 4k50A-5av7A:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b7z | UNCHARACTERIZEDPROTEIN TM_0416 (Thermotogamaritima) |
PF01261(AP_endonuc_2) | 3 | HIS A 208GLY A 68ILE A 110 | NI A 305 (-3.0A)NoneNone | 0.54A | 4k50A-5b7zA:undetectable | 4k50A-5b7zA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dfa | BETA-GALACTOSIDASE (Geobacillusstearothermophilus) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 3 | HIS A 604GLY A 597ILE A 595 | None | 0.55A | 4k50A-5dfaA:undetectable | 4k50A-5dfaA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e0c | CELLULASE (Bacillus sp.BG-CS10) |
PF00150(Cellulase)PF03442(CBM_X2) | 3 | HIS A 208GLY A 264ILE A 265 | None | 0.64A | 4k50A-5e0cA:undetectable | 4k50A-5e0cA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eb5 | HNL ISOENZYME 5 (Prunus dulcis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 3 | HIS A 7GLY A 104ILE A 108 | None | 0.56A | 4k50A-5eb5A:undetectable | 4k50A-5eb5A:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f56 | SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE (Deinococcusradiodurans) |
PF01368(DHH)PF02272(DHHA1) | 3 | HIS A 124GLY A 115ILE A 116 | None | 0.63A | 4k50A-5f56A:undetectable | 4k50A-5f56A:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzp | TRIOSEPHOSPHATEISOMERASE (Plasmodiumfalciparum) |
PF00121(TIM) | 3 | HIS A 95GLY A 210ILE A 170 | PGA A 301 (-4.0A)PGA A 301 (-3.5A)PGA A 301 (-4.6A) | 0.59A | 4k50A-5gzpA:0.9 | 4k50A-5gzpA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h60 | TRANSFERASE (Escherichiacoli) |
no annotation | 3 | HIS A 316GLY A 234ILE A 235 | None | 0.61A | 4k50A-5h60A:undetectable | 4k50A-5h60A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hqb | ALPHA-GLUCOSIDASE (Pseudoalteromonassp. K8) |
PF10566(Glyco_hydro_97)PF14508(GH97_N)PF14509(GH97_C) | 3 | HIS A 204GLY A 462ILE A 265 | None | 0.58A | 4k50A-5hqbA:undetectable | 4k50A-5hqbA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j3n | GREEN FLUORESCENTPROTEIN,HSDR (Escherichiacoli;Aequoreavictoria) |
PF01353(GFP)PF12008(EcoR124_C) | 3 | HIS A 83GLY A 234ILE A 235 | None | 0.58A | 4k50A-5j3nA:undetectable | 4k50A-5j3nA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jmv | PROBABLEBIFUNCTIONAL TRNATHREONYLCARBAMOYLADENOSINE BIOSYNTHESISPROTEIN (Methanocaldococcusjannaschii) |
PF00814(Peptidase_M22) | 3 | HIS A 106GLY A 286ILE A 289 | MG A 402 (-3.7A)NoneNone | 0.63A | 4k50A-5jmvA:undetectable | 4k50A-5jmvA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lsr | CCMP (Synechococcuselongatus) |
no annotation | 3 | HIS A 78GLY A 23ILE A 22 | None | 0.64A | 4k50A-5lsrA:undetectable | 4k50A-5lsrA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odr | METHYL-VIOLOGENREDUCINGHYDROGENASE, SUBUNITGMETHYL-VIOLOGENREDUCINGHYDROGENASE, SUBUNITA (Methanothermococcusthermolithotrophicus;Methanothermococcusthermolithotrophicus) |
PF01058(Oxidored_q6)PF00374(NiFeSe_Hases) | 3 | HIS F 102GLY F 62ILE E 17 | None | 0.64A | 4k50A-5odrF:undetectable | 4k50A-5odrF:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tpv | WLARA,TDP-FUCOSE-3,4-KETOISOMERASE (Campylobacterjejuni) |
PF05523(FdtA) | 3 | HIS A 21GLY A 86ILE A 57 | None | 0.64A | 4k50A-5tpvA:undetectable | 4k50A-5tpvA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tpv | WLARA,TDP-FUCOSE-3,4-KETOISOMERASE (Campylobacterjejuni) |
PF05523(FdtA) | 3 | HIS A 21GLY A 86ILE A 59 | None | 0.61A | 4k50A-5tpvA:undetectable | 4k50A-5tpvA:14.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xe0 | GENOME POLYPROTEIN (Enterovirus D) |
PF00680(RdRP_1) | 3 | HIS A 195GLY A 288ILE A 291 | None | 0.33A | 4k50A-5xe0A:51.9 | 4k50A-5xe0A:55.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xk8 | UNDECAPRENYLDIPHOSPHATE SYNTHASE (Streptomycessp. CNH189) |
no annotation | 3 | HIS A 118GLY A 89ILE A 120 | None | 0.62A | 4k50A-5xk8A:undetectable | 4k50A-5xk8A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ydj | ACETYLCHOLINESTERASE (Anophelesgambiae) |
no annotation | 3 | HIS A 559GLY A 445ILE A 446 | None | 0.64A | 4k50A-5ydjA:undetectable | 4k50A-5ydjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ygk | - (-) |
no annotation | 3 | HIS A 118GLY A 89ILE A 120 | None | 0.64A | 4k50A-5ygkA:undetectable | 4k50A-5ygkA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6anr | COLIBACTINSELF-PROTECTIONPROTEIN CLBS (Escherichiacoli) |
no annotation | 3 | HIS A 67GLY A 143ILE A 146 | None | 0.58A | 4k50A-6anrA:undetectable | 4k50A-6anrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ap6 | PROBABLESTRIGOLACTONEESTERASE DAD2 (Petunia xhybrida) |
no annotation | 3 | HIS A 249GLY A 120ILE A 119 | None | 0.60A | 4k50A-6ap6A:undetectable | 4k50A-6ap6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6arx | ACETYLCHOLINESTERASE (Anophelesgambiae) |
no annotation | 3 | HIS A 559GLY A 445ILE A 446 | None | 0.63A | 4k50A-6arxA:undetectable | 4k50A-6arxA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ei9 | TRNA-DIHYDROURIDINESYNTHASE B (Escherichiacoli) |
no annotation | 3 | HIS A 282GLY A 19ILE A 20 | NoneNoneFMN A 401 ( 4.6A) | 0.64A | 4k50A-6ei9A:undetectable | 4k50A-6ei9A:undetectable |