SIMILAR PATTERNS OF AMINO ACIDS FOR 4K50_B_ACTB701_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bl5 ISOCITRATE
DEHYDROGENASE


(Escherichia
coli)
PF00180
(Iso_dh)
3 HIS A 366
GLY A 329
ILE A 328
None
0.62A 4k50A-1bl5A:
undetectable
4k50A-1bl5A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa)
PF00135
(COesterase)
3 HIS A 368
GLY A 252
ILE A 253
None
0.61A 4k50A-1crlA:
0.0
4k50A-1crlA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE


(Desulfovibrio
desulfuricans)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
3 HIS A 242
GLY A 224
ILE A 225
None
0.58A 4k50A-1dgjA:
0.0
4k50A-1dgjA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE


(Saccharomyces
cerevisiae)
PF00215
(OMPdecase)
3 HIS A  13
GLY A 181
ILE A 180
None
0.64A 4k50A-1dqwA:
0.0
4k50A-1dqwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus)
no annotation 3 HIS A  98
GLY A 250
ILE A 245
None
0.51A 4k50A-1nnwA:
0.0
4k50A-1nnwA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rdr POLIOVIRUS 3D
POLYMERASE


(Enterovirus C)
PF00680
(RdRP_1)
3 HIS A 199
GLY A 292
ILE A 295
None
0.48A 4k50A-1rdrA:
36.7
4k50A-1rdrA:
56.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sie POLYOMAVIRUS COAT
PROTEIN VP1


(Mus musculus
polyomavirus 1)
PF00718
(Polyoma_coat)
3 HIS A 163
GLY A 287
ILE A 285
None
0.51A 4k50A-1sieA:
undetectable
4k50A-1sieA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbr ENDO-1,4-BETA-XYLANA
SE B


(Thermotoga
maritima)
PF00331
(Glyco_hydro_10)
3 HIS A 596
GLY A 720
ILE A 686
None
0.54A 4k50A-1vbrA:
0.0
4k50A-1vbrA:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B)
PF00680
(RdRP_1)
3 HIS A 199
GLY A 291
ILE A 294
None
0.41A 4k50A-1xr5A:
51.8
4k50A-1xr5A:
55.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A)
PF00680
(RdRP_1)
3 HIS A 199
GLY A 291
ILE A 294
None
0.51A 4k50A-1xr6A:
55.5
4k50A-1xr6A:
85.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE


(Thermus
thermophilus)
PF00121
(TIM)
3 HIS A  94
GLY A 211
ILE A 171
None
PO4  A2004 ( 3.9A)
PO4  A2004 (-4.4A)
0.64A 4k50A-1yyaA:
undetectable
4k50A-1yyaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT


(Rhodococcus sp.
NCIMB 12038)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
3 HIS A 295
GLY A 240
ILE A 254
IND  A 503 (-3.5A)
None
None
0.62A 4k50A-2b24A:
undetectable
4k50A-2b24A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdv PHAGE-RELATED
CONSERVED
HYPOTHETICAL
PROTEIN, BB2244


(Bordetella
bronchiseptica)
PF02586
(SRAP)
3 HIS A  82
GLY A  91
ILE A  90
None
0.56A 4k50A-2bdvA:
undetectable
4k50A-2bdvA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE


(Bacillus
circulans)
PF01041
(DegT_DnrJ_EryC1)
3 HIS A 168
GLY A 200
ILE A 201
None
0.56A 4k50A-2c81A:
undetectable
4k50A-2c81A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)


(Homo sapiens)
PF03051
(Peptidase_C1_2)
3 HIS A 257
GLY A 246
ILE A 248
None
0.53A 4k50A-2cb5A:
undetectable
4k50A-2cb5A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III


(Homo sapiens)
PF05822
(UMPH-1)
3 HIS A 107
GLY A 155
ILE A 156
None
0.53A 4k50A-2cn1A:
undetectable
4k50A-2cn1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis)
PF04185
(Phosphoesterase)
3 HIS A 109
GLY A 407
ILE A 206
None
0.63A 4k50A-2d1gA:
undetectable
4k50A-2d1gA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ett SORTING NEXIN-22

(Homo sapiens)
PF00787
(PX)
3 HIS A  59
GLY A  97
ILE A  98
None
0.64A 4k50A-2ettA:
undetectable
4k50A-2ettA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gju 252AA LONG
HYPOTHETICAL PROTEIN


(Pyrococcus
horikoshii)
no annotation 3 HIS A  98
GLY A 250
ILE A 245
None
0.58A 4k50A-2gjuA:
undetectable
4k50A-2gjuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iaf HYPOTHETICAL PROTEIN
SDHL


(Legionella
pneumophila)
PF03315
(SDH_beta)
3 HIS A 111
GLY A 136
ILE A 135
None
0.62A 4k50A-2iafA:
undetectable
4k50A-2iafA:
16.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE


(Enterovirus C)
PF00548
(Peptidase_C3)
PF00680
(RdRP_1)
3 HIS 1 382
GLY 1 475
ILE 1 478
None
0.28A 4k50A-2ijd1:
51.2
4k50A-2ijd1:
41.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE


(Rauvolfia
serpentina)
PF00232
(Glyco_hydro_1)
3 HIS A 442
GLY A 482
ILE A 483
None
0.57A 4k50A-2jf7A:
undetectable
4k50A-2jf7A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjm GLYCOSYL
TRANSFERASE, GROUP 1
FAMILY PROTEIN


(Bacillus
anthracis)
PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4)
3 HIS A  93
GLY A  24
ILE A   7
None
0.60A 4k50A-2jjmA:
undetectable
4k50A-2jjmA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrk HYPOTHETICAL PROTEIN
GRPB


(Enterococcus
faecalis)
PF04229
(GrpB)
3 HIS A 101
GLY A  38
ILE A  37
None
0.59A 4k50A-2nrkA:
undetectable
4k50A-2nrkA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ond CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT


(Mus musculus)
PF05843
(Suf)
3 HIS A 360
GLY A 394
ILE A 397
None
0.53A 4k50A-2ondA:
undetectable
4k50A-2ondA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT


(Mus musculus)
PF05843
(Suf)
3 HIS A 360
GLY A 394
ILE A 397
None
0.43A 4k50A-2ooeA:
1.1
4k50A-2ooeA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN


(Azospirillum
brasilense)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
3 HIS A  58
GLY A 106
ILE A 132
None
0.60A 4k50A-2vdcA:
undetectable
4k50A-2vdcA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE


(Methanocaldococcus
jannaschii)
PF00814
(Peptidase_M22)
PF01163
(RIO1)
3 HIS A 106
GLY A 286
ILE A 289
ANP  A1531 (-3.4A)
None
None
0.56A 4k50A-2vwbA:
undetectable
4k50A-2vwbA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)


(Mycobacterium
tuberculosis)
PF13185
(GAF_2)
3 HIS A  89
GLY A 122
ILE A 125
None
0.33A 4k50A-2w3gA:
undetectable
4k50A-2w3gA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wj9 INTERGENIC-REGION
PROTEIN


(Escherichia
coli)
PF03230
(Antirestrict)
3 HIS A 135
GLY A  41
ILE A  43
None
0.56A 4k50A-2wj9A:
undetectable
4k50A-2wj9A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca)
PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372)
3 HIS A 767
GLY A 805
ILE A 798
None
0.59A 4k50A-2yocA:
undetectable
4k50A-2yocA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2


(Saccharomyces
cerevisiae)
PF00180
(Iso_dh)
3 HIS B 308
GLY B 271
ILE B 270
None
0.51A 4k50A-3blxB:
undetectable
4k50A-3blxB:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enh UNCHARACTERIZED
PROTEIN MJ0187


(Methanocaldococcus
jannaschii)
PF08617
(CGI-121)
3 HIS C  40
GLY C  68
ILE C 142
None
0.49A 4k50A-3enhC:
undetectable
4k50A-3enhC:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f13 PUTATIVE NUDIX
HYDROLASE FAMILY
MEMBER


(Chromobacterium
violaceum)
PF00293
(NUDIX)
3 HIS A  85
GLY A 121
ILE A 124
None
0.58A 4k50A-3f13A:
undetectable
4k50A-3f13A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1


(Prunus dulcis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
3 HIS A   7
GLY A 104
ILE A 108
None
0.60A 4k50A-3gdnA:
undetectable
4k50A-3gdnA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE


(Yersinia pestis)
PF00709
(Adenylsucc_synt)
3 HIS A 169
GLY A 146
ILE A 165
None
0.54A 4k50A-3hidA:
undetectable
4k50A-3hidA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ite SIDN SIDEROPHORE
SYNTHETASE


(Epichloe
festucae)
PF00501
(AMP-binding)
3 HIS A 270
GLY A 207
ILE A 206
None
0.61A 4k50A-3iteA:
undetectable
4k50A-3iteA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ja7 PORTAL PROTEIN GP20

(Escherichia
virus T4)
PF07230
(Peptidase_S80)
3 HIS A 136
GLY A 170
ILE A 171
None
0.58A 4k50A-3ja7A:
undetectable
4k50A-3ja7A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0r RESPONSE REGULATOR

(Caulobacter
vibrioides)
PF00072
(Response_reg)
3 HIS A 165
GLY A 252
ILE A 251
None
0.60A 4k50A-3n0rA:
undetectable
4k50A-3n0rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE


(Francisella
tularensis)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
3 HIS A 472
GLY A 159
ILE A 162
None
0.53A 4k50A-3peiA:
undetectable
4k50A-3peiA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
3 HIS A 330
GLY A 313
ILE A 165
GOL  A 513 (-4.1A)
GOL  A 512 ( 4.4A)
None
0.48A 4k50A-3ramA:
undetectable
4k50A-3ramA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN


(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
3 HIS A 156
GLY A 418
ILE A 419
None
0.60A 4k50A-3snxA:
undetectable
4k50A-3snxA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE


(Yersinia pestis)
PF00696
(AA_kinase)
3 HIS A  41
GLY A 100
ILE A 143
None
0.60A 4k50A-3t7bA:
undetectable
4k50A-3t7bA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vg8 HYPOTHETICAL PROTEIN
TTHB210


(Thermus
thermophilus)
no annotation 3 HIS G  87
GLY G  17
ILE G  15
None
0.59A 4k50A-3vg8G:
undetectable
4k50A-3vg8G:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC


(Dictyostelium
discoideum)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
3 HIS A3223
GLY A3590
ILE A3626
None
0.64A 4k50A-3vkgA:
undetectable
4k50A-3vkgA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa)
PF12697
(Abhydrolase_6)
3 HIS A 300
GLY A 171
ILE A 170
None
0.64A 4k50A-3w04A:
undetectable
4k50A-3w04A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE


(Sphingopyxis
sp. 113P3)
no annotation 3 HIS A 279
GLY A  49
ILE A 155
SO4  A 901 ( 4.4A)
SO4  A 901 ( 3.7A)
None
0.64A 4k50A-3wlaA:
undetectable
4k50A-3wlaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE


(Sphingopyxis
sp. 113P3)
no annotation 3 HIS A 279
GLY A 158
ILE A 155
SO4  A 901 ( 4.4A)
None
None
0.59A 4k50A-3wlaA:
undetectable
4k50A-3wlaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE


(Sphingopyxis
sp. 113P3)
no annotation 3 HIS A 279
GLY A 159
ILE A 155
SO4  A 901 ( 4.4A)
None
None
0.56A 4k50A-3wlaA:
undetectable
4k50A-3wlaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE


(Pseudomonas sp.
VM15C)
no annotation 3 HIS A 298
GLY A 174
ILE A 171
None
0.60A 4k50A-3wweA:
undetectable
4k50A-3wweA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE


(Pseudomonas sp.
VM15C)
no annotation 3 HIS A 298
GLY A 175
ILE A 171
None
0.52A 4k50A-3wweA:
undetectable
4k50A-3wweA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP


(Salmonella
enterica)
PF00814
(Peptidase_M22)
3 HIS B 111
GLY B 302
ILE B 305
ZN  B1339 ( 3.2A)
None
None
0.60A 4k50A-3zeuB:
undetectable
4k50A-3zeuB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1


(Mus musculus)
PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest)
3 HIS A 811
GLY A 786
ILE A 876
None
NAG  A2001 ( 4.9A)
None
0.54A 4k50A-4b56A:
undetectable
4k50A-4b56A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dia 2-PYRONE-4,6-DICARBA
XYLATE HYDROLASE


(Sphingomonas
paucimobilis)
PF04909
(Amidohydro_2)
3 HIS A 152
GLY A  99
ILE A 100
None
0.61A 4k50A-4diaA:
undetectable
4k50A-4diaA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxw ION TRANSPORT
PROTEIN


(alpha
proteobacterium
HIMB114)
PF00520
(Ion_trans)
3 HIS A  45
GLY A  30
ILE A  29
None
0.61A 4k50A-4dxwA:
undetectable
4k50A-4dxwA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
3 HIS A 166
GLY A 232
ILE A 162
None
0.62A 4k50A-4egeA:
undetectable
4k50A-4egeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 MGC81050 PROTEIN

(Xenopus laevis)
PF00400
(WD40)
3 HIS B 244
GLY B 250
ILE B 248
None
0.63A 4k50A-4g56B:
undetectable
4k50A-4g56B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9
ACTIN-LIKE PROTEIN
ARP9


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF00022
(Actin)
PF07529
(HSA)
3 HIS C 637
GLY B 431
ILE B 434
None
0.59A 4k50A-4i6mC:
undetectable
4k50A-4i6mC:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Polaromonas sp.
JS666)
no annotation 3 HIS C 195
GLY C 188
ILE C 189
NAP  C 304 (-3.9A)
NAP  C 304 (-4.8A)
NAP  C 304 ( 4.7A)
0.64A 4k50A-4iqgC:
undetectable
4k50A-4iqgC:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgc BILE ACID-COENZYME A
LIGASE


([Clostridium]
scindens)
PF00501
(AMP-binding)
3 HIS A 294
GLY A 333
ILE A 316
None
0.60A 4k50A-4lgcA:
undetectable
4k50A-4lgcA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans)
PF01301
(Glyco_hydro_35)
3 HIS A 565
GLY A 406
ILE A 417
None
0.63A 4k50A-4madA:
undetectable
4k50A-4madA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D


(Arabidopsis
thaliana)
PF01965
(DJ-1_PfpI)
3 HIS A 371
GLY A 282
ILE A 312
None
0.57A 4k50A-4ofwA:
undetectable
4k50A-4ofwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1


(Homo sapiens)
PF00069
(Pkinase)
3 HIS A1024
GLY A 892
ILE A 895
None
0.64A 4k50A-4qpmA:
undetectable
4k50A-4qpmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku CHLOROPHYLL A-B
BINDING PROTEIN 6A,
CHLOROPLASTIC


(Pisum sativum)
PF00504
(Chloroa_b-bind)
3 HIS 1 178
GLY 1  57
ILE 1 182
None
CLA  11004 (-4.5A)
CLA  11007 (-4.4A)
0.63A 4k50A-4rku1:
undetectable
4k50A-4rku1:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvs PROBABLE QUINONE
REDUCTASE QOR
(NADPH:QUINONE
REDUCTASE)
(ZETA-CRYSTALLIN
HOMOLOG PROTEIN)


(Mycobacterium
tuberculosis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 HIS A 313
GLY A  61
ILE A  60
None
0.64A 4k50A-4rvsA:
undetectable
4k50A-4rvsA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum)
PF00400
(WD40)
3 HIS A  88
GLY A  46
ILE A  42
None
0.59A 4k50A-4wjsA:
undetectable
4k50A-4wjsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE


(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
3 HIS A 310
GLY A 426
ILE A 440
None
0.59A 4k50A-4wkyA:
undetectable
4k50A-4wkyA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y90 TRIOSEPHOSPHATE
ISOMERASE


(Deinococcus
radiodurans)
PF00121
(TIM)
3 HIS A  96
GLY A 208
ILE A 169
CA  A 305 (-4.3A)
SO4  A 301 ( 3.9A)
SO4  A 301 (-4.8A)
0.64A 4k50A-4y90A:
undetectable
4k50A-4y90A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE


(Gemmata
obscuriglobus)
PF00121
(TIM)
3 HIS A  99
GLY A 216
ILE A 176
NA  A 301 (-4.3A)
PO4  A 303 ( 4.2A)
PO4  A 303 (-4.8A)
0.62A 4k50A-4y96A:
undetectable
4k50A-4y96A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu4 HEMOGLOBIN

(Helogale
parvula)
PF00042
(Globin)
3 HIS A 113
GLY A  18
ILE A  17
None
0.64A 4k50A-4yu4A:
undetectable
4k50A-4yu4A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG


(Bacillus
subtilis)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
3 HIS A 261
GLY A 275
ILE A 276
None
0.64A 4k50A-4yxtA:
undetectable
4k50A-4yxtA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6k ALCOHOL
DEHYDROGENASE


(Moraxella sp.
TAE123)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 HIS A  76
GLY A 132
ILE A 133
None
0.60A 4k50A-4z6kA:
undetectable
4k50A-4z6kA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT


(Sulfurisphaera
tokodaii)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
3 HIS A 663
GLY A 418
ILE A 489
None
0.56A 4k50A-4zohA:
undetectable
4k50A-4zohA:
24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zpd RNA-DIRECTED RNA
POLYMERASE


(Enterovirus B)
PF00680
(RdRP_1)
3 HIS A 199
GLY A 293
ILE A 296
None
0.28A 4k50A-4zpdA:
52.5
4k50A-4zpdA:
57.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2g CARBOXYLIC ESTER
HYDROLASE


(Hungatella
hathewayi)
PF00135
(COesterase)
3 HIS A 145
GLY A 202
ILE A 111
None
0.43A 4k50A-5a2gA:
undetectable
4k50A-5a2gA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II)
3 HIS K 353
GLY K 244
ILE K 351
None
0.60A 4k50A-5anbK:
undetectable
4k50A-5anbK:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5auo ATPASE INVOLVED IN
CHROMOSOME
PARTITIONING,
PARA/MIND FAMILY,
MRP HOMOLOG


(Thermococcus
kodakarensis)
PF10609
(ParA)
3 HIS B  59
GLY B 107
ILE B 110
None
0.58A 4k50A-5auoB:
undetectable
4k50A-5auoB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5av7 LECTIN

(Calystegia
sepium)
PF01419
(Jacalin)
3 HIS A 111
GLY A  78
ILE A  77
None
0.62A 4k50A-5av7A:
undetectable
4k50A-5av7A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7z UNCHARACTERIZED
PROTEIN TM_0416


(Thermotoga
maritima)
PF01261
(AP_endonuc_2)
3 HIS A 208
GLY A  68
ILE A 110
NI  A 305 (-3.0A)
None
None
0.54A 4k50A-5b7zA:
undetectable
4k50A-5b7zA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
3 HIS A 604
GLY A 597
ILE A 595
None
0.55A 4k50A-5dfaA:
undetectable
4k50A-5dfaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10)
PF00150
(Cellulase)
PF03442
(CBM_X2)
3 HIS A 208
GLY A 264
ILE A 265
None
0.64A 4k50A-5e0cA:
undetectable
4k50A-5e0cA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
3 HIS A   7
GLY A 104
ILE A 108
None
0.56A 4k50A-5eb5A:
undetectable
4k50A-5eb5A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE


(Deinococcus
radiodurans)
PF01368
(DHH)
PF02272
(DHHA1)
3 HIS A 124
GLY A 115
ILE A 116
None
0.63A 4k50A-5f56A:
undetectable
4k50A-5f56A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzp TRIOSEPHOSPHATE
ISOMERASE


(Plasmodium
falciparum)
PF00121
(TIM)
3 HIS A  95
GLY A 210
ILE A 170
PGA  A 301 (-4.0A)
PGA  A 301 (-3.5A)
PGA  A 301 (-4.6A)
0.59A 4k50A-5gzpA:
0.9
4k50A-5gzpA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h60 TRANSFERASE

(Escherichia
coli)
no annotation 3 HIS A 316
GLY A 234
ILE A 235
None
0.61A 4k50A-5h60A:
undetectable
4k50A-5h60A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8)
PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C)
3 HIS A 204
GLY A 462
ILE A 265
None
0.58A 4k50A-5hqbA:
undetectable
4k50A-5hqbA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3n GREEN FLUORESCENT
PROTEIN,HSDR


(Escherichia
coli;
Aequorea
victoria)
PF01353
(GFP)
PF12008
(EcoR124_C)
3 HIS A  83
GLY A 234
ILE A 235
None
0.58A 4k50A-5j3nA:
undetectable
4k50A-5j3nA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmv PROBABLE
BIFUNCTIONAL TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN


(Methanocaldococcus
jannaschii)
PF00814
(Peptidase_M22)
3 HIS A 106
GLY A 286
ILE A 289
MG  A 402 (-3.7A)
None
None
0.63A 4k50A-5jmvA:
undetectable
4k50A-5jmvA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsr CCMP

(Synechococcus
elongatus)
no annotation 3 HIS A  78
GLY A  23
ILE A  22
None
0.64A 4k50A-5lsrA:
undetectable
4k50A-5lsrA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A


(Methanothermococcus
thermolithotrophicus;
Methanothermococcus
thermolithotrophicus)
PF01058
(Oxidored_q6)
PF00374
(NiFeSe_Hases)
3 HIS F 102
GLY F  62
ILE E  17
None
0.64A 4k50A-5odrF:
undetectable
4k50A-5odrF:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE


(Campylobacter
jejuni)
PF05523
(FdtA)
3 HIS A  21
GLY A  86
ILE A  57
None
0.64A 4k50A-5tpvA:
undetectable
4k50A-5tpvA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE


(Campylobacter
jejuni)
PF05523
(FdtA)
3 HIS A  21
GLY A  86
ILE A  59
None
0.61A 4k50A-5tpvA:
undetectable
4k50A-5tpvA:
14.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xe0 GENOME POLYPROTEIN

(Enterovirus D)
PF00680
(RdRP_1)
3 HIS A 195
GLY A 288
ILE A 291
None
0.33A 4k50A-5xe0A:
51.9
4k50A-5xe0A:
55.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xk8 UNDECAPRENYL
DIPHOSPHATE SYNTHASE


(Streptomyces
sp. CNH189)
no annotation 3 HIS A 118
GLY A  89
ILE A 120
None
0.62A 4k50A-5xk8A:
undetectable
4k50A-5xk8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae)
no annotation 3 HIS A 559
GLY A 445
ILE A 446
None
0.64A 4k50A-5ydjA:
undetectable
4k50A-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygk -

(-)
no annotation 3 HIS A 118
GLY A  89
ILE A 120
None
0.64A 4k50A-5ygkA:
undetectable
4k50A-5ygkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anr COLIBACTIN
SELF-PROTECTION
PROTEIN CLBS


(Escherichia
coli)
no annotation 3 HIS A  67
GLY A 143
ILE A 146
None
0.58A 4k50A-6anrA:
undetectable
4k50A-6anrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2


(Petunia x
hybrida)
no annotation 3 HIS A 249
GLY A 120
ILE A 119
None
0.60A 4k50A-6ap6A:
undetectable
4k50A-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae)
no annotation 3 HIS A 559
GLY A 445
ILE A 446
None
0.63A 4k50A-6arxA:
undetectable
4k50A-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B


(Escherichia
coli)
no annotation 3 HIS A 282
GLY A  19
ILE A  20
None
None
FMN  A 401 ( 4.6A)
0.64A 4k50A-6ei9A:
undetectable
4k50A-6ei9A:
undetectable