SIMILAR PATTERNS OF AMINO ACIDS FOR 4K4Y_A_ACTA502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aei ANNEXIN XII

(Hydra vulgaris) 		PF00191
(Annexin) 		4 LEU A 220
GLU A 224
LEU A 236
LYS A 240
 None
 1.19A 4k4yA-1aeiA:
0.0		 4k4yA-1aeiA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8i PROTEIN
(ULTRABITHORAX
HOMEOTIC PROTEIN IV)

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		4 LYS A 118
LEU A 116
GLU A 115
LEU A 138
 None
 1.38A 4k4yA-1b8iA:
undetectable		 4k4yA-1b8iA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpo PROTEIN (CLATHRIN)

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link)
PF13838
(Clathrin_H_link) 		4 LYS A 453
LEU A 452
GLU A 449
LEU A 448
 None
 1.27A 4k4yA-1bpoA:
0.0		 4k4yA-1bpoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		4 LYS A 806
LEU A 826
GLU A 828
LEU A 763
 None
 1.22A 4k4yA-1d5fA:
0.0		 4k4yA-1d5fA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcq PYK2-ASSOCIATED
PROTEIN BETA

(Mus musculus) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		4 LYS A 466
LEU A 467
GLU A 463
LEU A 429
 None
 1.16A 4k4yA-1dcqA:
0.0		 4k4yA-1dcqA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnw GLUTATHIONE
S-TRANSFERASE

(Arabidopsis
thaliana) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LYS A 142
LEU A 143
GLU A 139
LEU A 117
 None
 1.19A 4k4yA-1gnwA:
0.0		 4k4yA-1gnwA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		4 LYS A 405
LEU A 406
GLU A 250
LEU A 254
 None
None
None
HEM  A 800 (-4.1A)
 1.38A 4k4yA-1itkA:
0.0		 4k4yA-1itkA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0r 4 ANKYRIN REPEATS

(-) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 LEU A  86
GLU A  82
LEU A  48
LYS A  52
 None
 1.29A 4k4yA-1n0rA:
undetectable		 4k4yA-1n0rA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Thermotoga
maritima) 		PF00171
(Aldedh) 		4 LYS A   7
LEU A   4
GLU A   3
LEU A 185
 None
 1.27A 4k4yA-1o20A:
0.0		 4k4yA-1o20A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 4 LYS A 471
LEU A 472
GLU A 468
LEU A 211
 None
 1.24A 4k4yA-1qi9A:
0.0		 4k4yA-1qi9A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LYS B 226
LEU B 224
GLU B 223
LEU B 315
 None
 1.29A 4k4yA-1umbB:
0.0		 4k4yA-1umbB:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3a TRNA-SPECIFIC
ADENOSINE DEAMINASE

(Escherichia
coli) 		PF14437
(MafB19-deam) 		4 LEU A 155
GLU A 151
LEU A  27
LYS A  31
 None
 1.25A 4k4yA-1z3aA:
undetectable		 4k4yA-1z3aA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 LYS A 760
LEU A 759
GLU A 571
LEU A 567
 None
 1.31A 4k4yA-2bucA:
undetectable		 4k4yA-2bucA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 LYS A 301
LEU A 302
GLU A 298
LEU A 382
 None
 1.29A 4k4yA-2dq3A:
undetectable		 4k4yA-2dq3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LYS A 133
LEU A 131
GLU A 130
LEU A 219
 None
 1.21A 4k4yA-2ep5A:
undetectable		 4k4yA-2ep5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h92 CYTIDYLATE KINASE

(Staphylococcus
aureus) 		PF02224
(Cytidylate_kin) 		4 LYS A  56
LEU A  57
LEU A  48
LYS A  44
 None
 1.24A 4k4yA-2h92A:
undetectable		 4k4yA-2h92A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixf ANTIGEN PEPTIDE
TRANSPORTER 1

(Rattus
norvegicus) 		PF00005
(ABC_tran) 		4 LYS A 637
LEU A 634
GLU A 667
LEU A 661
 None
 1.22A 4k4yA-2ixfA:
undetectable		 4k4yA-2ixfA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sinapis alba) 		PF00348
(polyprenyl_synt) 		4 LYS A 155
LEU A 153
GLU A 152
LEU A 203
 None
 1.32A 4k4yA-2j1oA:
1.5		 4k4yA-2j1oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k6m SUPERVILLIN

(Homo sapiens) 		PF02209
(VHP) 		4 LYS S  70
LEU S  75
GLU S  39
LEU S  42
 None
 1.27A 4k4yA-2k6mS:
undetectable		 4k4yA-2k6mS:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kho HEAT SHOCK PROTEIN
70

(Escherichia
coli) 		PF00012
(HSP70) 		4 LYS A 577
LEU A 576
GLU A 573
LEU A 543
 None
 1.35A 4k4yA-2khoA:
undetectable		 4k4yA-2khoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o79 LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 LYS A  48
LEU A  46
GLU A  45
LEU A  33
 None
 1.26A 4k4yA-2o79A:
undetectable		 4k4yA-2o79A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0g SELENOPROTEIN
W-RELATED PROTEIN

(Vibrio cholerae) 		PF10262
(Rdx) 		4 LYS A  73
LEU A  72
GLU A  26
LEU A  23
 None
 1.32A 4k4yA-2p0gA:
undetectable		 4k4yA-2p0gA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Methanosarcina
mazei) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		4 LYS B 299
LEU B 300
GLU B 296
LEU B 283
 None
 1.06A 4k4yA-2q2eB:
undetectable		 4k4yA-2q2eB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00149
(Metallophos) 		4 LYS A 188
LEU A 164
GLU A 166
LEU A 177
 None
 1.03A 4k4yA-2qjcA:
undetectable		 4k4yA-2qjcA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 LYS A 491
LEU A 490
GLU A 487
LEU A 482
 None
 1.38A 4k4yA-2r9vA:
undetectable		 4k4yA-2r9vA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9s PEROXIREDOXIN-1

(Rattus
norvegicus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LYS A  68
LEU A  69
GLU A  65
LEU A 157
 None
 1.17A 4k4yA-2z9sA:
undetectable		 4k4yA-2z9sA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeb SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
CYTOCHROME B SMALL
SUBUNIT,
MITOCHONDRIAL

(Sus scrofa;
Sus scrofa) 		PF01127
(Sdh_cyt)
PF05328
(CybS) 		4 LYS D 135
LEU D 136
LEU C  74
LYS C  78
 None
 1.09A 4k4yA-3aebD:
undetectable		 4k4yA-3aebD:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crw XPD/RAD3 RELATED DNA
HELICASE

(Sulfolobus
acidocaldarius) 		PF06733
(DEAD_2)
PF13307
(Helicase_C_2) 		4 LYS 1 539
LEU 1 541
LEU 1 505
LYS 1 509
 None
 1.34A 4k4yA-3crw1:
undetectable		 4k4yA-3crw1:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LYS A 193
LEU A 194
GLU A 190
LEU A 308
 None
 0.97A 4k4yA-3eyaA:
undetectable		 4k4yA-3eyaA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		4 LYS A 238
LEU A 239
GLU A 235
LEU A 221
 None
 1.07A 4k4yA-3f6tA:
undetectable		 4k4yA-3f6tA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR

(Bacillus
anthracis) 		PF12207
(DUF3600) 		4 LYS A  54
LEU A  55
GLU A  51
LEU A  89
 None
 1.21A 4k4yA-3fh3A:
undetectable		 4k4yA-3fh3A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fiq ODORANT-BINDING
PROTEIN 1F

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		4 LYS A  92
LEU A  91
GLU A 131
LEU A 135
 None
 1.18A 4k4yA-3fiqA:
undetectable		 4k4yA-3fiqA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkf THIOL-DISULFIDE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF13905
(Thioredoxin_8) 		4 LYS A 139
LEU A 138
GLU A  58
LEU A  55
 None
 1.23A 4k4yA-3fkfA:
undetectable		 4k4yA-3fkfA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5l PUTATIVE
S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Listeria
monocytogenes) 		PF13649
(Methyltransf_25) 		4 LYS A  36
LEU A  34
GLU A  33
LEU A 237
 None
 1.24A 4k4yA-3g5lA:
undetectable		 4k4yA-3g5lA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdv RESPONSE REGULATOR

(Pseudomonas
putida) 		PF00072
(Response_reg) 		4 LYS A 187
LEU A 186
GLU A 185
LEU A 116
 None
 0.89A 4k4yA-3hdvA:
undetectable		 4k4yA-3hdvA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF2
PRE-MRNA-SPLICING
FACTOR CWF5

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00076
(RRM_1)
PF16131
(Torus)
PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 LYS a 101
LEU a 100
GLU Y 263
LEU a 143
 None
 1.03A 4k4yA-3jb9a:
undetectable		 4k4yA-3jb9a:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 LYS A  80
LEU A  81
GLU A  77
LEU A  47
 None
 1.05A 4k4yA-3kl4A:
undetectable		 4k4yA-3kl4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kln TRANSCRIPTIONAL
REGULATOR, LUXR
FAMILY

(Vibrio cholerae) 		PF00196
(GerE) 		4 LYS A  23
LEU A  26
GLU A  27
LEU A  32
 None
 1.29A 4k4yA-3klnA:
undetectable		 4k4yA-3klnA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 LEU A 719
GLU A 786
LEU A 715
LYS A 713
 None
 1.32A 4k4yA-3l4kA:
undetectable		 4k4yA-3l4kA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 LYS A 309
LEU A 306
GLU A 305
LEU A 378
 None
 1.36A 4k4yA-3l8aA:
undetectable		 4k4yA-3l8aA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzx FERREDOXIN--NADP
REDUCTASE 2

(Bacillus
subtilis) 		PF07992
(Pyr_redox_2) 		4 LYS A 128
LEU A 129
GLU A 138
LEU A 142
 None
 1.28A 4k4yA-3lzxA:
undetectable		 4k4yA-3lzxA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		4 LYS A 214
LEU A 213
GLU A 212
LEU A 209
 None
 1.31A 4k4yA-3m1mA:
2.0		 4k4yA-3m1mA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Streptococcus
suis) 		PF01297
(ZnuA) 		4 LYS A 152
LEU A 153
GLU A 149
LEU A  85
 None
 0.79A 4k4yA-3mfqA:
undetectable		 4k4yA-3mfqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2n ANTHRAX TOXIN
RECEPTOR 1

(Homo sapiens) 		no annotation 4 LYS F 111
LEU F 109
GLU F 108
LEU F  92
 None
None
None
ACT  F 224 ( 4.7A)
 1.33A 4k4yA-3n2nF:
undetectable		 4k4yA-3n2nF:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Roseobacter
denitrificans) 		PF01039
(Carboxyl_trans) 		4 LYS B 322
LEU B 319
GLU B 318
LEU B 305
 None
 1.29A 4k4yA-3n6rB:
undetectable		 4k4yA-3n6rB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 LYS A 130
LEU A 131
GLU A 127
LEU A  43
 None
 0.92A 4k4yA-3p0fA:
undetectable		 4k4yA-3p0fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 LYS A 157
LEU A 158
GLU A 154
LEU A 760
 None
 1.30A 4k4yA-3qr1A:
undetectable		 4k4yA-3qr1A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4r PHOSPHOPROTEIN

(Lettuce
necrotic
yellows
cytorhabdovirus) 		no annotation 4 LYS A  10
LEU A  11
GLU A   7
LEU A  39
 None
 1.38A 4k4yA-3t4rA:
undetectable		 4k4yA-3t4rA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 LYS A   4
LEU A   6
GLU A  31
LEU A 232
 None
 1.32A 4k4yA-3toxA:
undetectable		 4k4yA-3toxA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tze TRYPTOPHANYL-TRNA
SYNTHETASE

(Encephalitozoon
cuniculi) 		PF00579
(tRNA-synt_1b) 		4 LYS A 334
LEU A 332
GLU A 331
LEU A 326
 None
 1.27A 4k4yA-3tzeA:
undetectable		 4k4yA-3tzeA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf6 LMO1369 PROTEIN

(Listeria
monocytogenes) 		PF01515
(PTA_PTB) 		4 LYS A 275
LEU A 276
GLU A  30
LEU A  34
 None
 1.36A 4k4yA-3uf6A:
undetectable		 4k4yA-3uf6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vup BETA-1,4-MANNANASE

(Aplysia kurodai) 		PF00150
(Cellulase) 		4 LYS A  50
LEU A  51
GLU A  47
LEU A 324
 None
 1.37A 4k4yA-3vupA:
undetectable		 4k4yA-3vupA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 557
LEU A 570
GLU A 572
LEU A 584
 None
 1.22A 4k4yA-4at3A:
undetectable		 4k4yA-4at3A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		4 LYS B 672
LEU B 673
GLU B 669
LEU B 735
 None
 0.99A 4k4yA-4b93B:
undetectable		 4k4yA-4b93B:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LYS A 877
LEU A 875
GLU A 874
LEU A 864
 None
 1.32A 4k4yA-4c3hA:
undetectable		 4k4yA-4c3hA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7n MICROPHTHALMIA
ASSOCIATED
TRANSCRIPTION FACTOR
SYNTHETIC
ALPHA-HELIX, IM10

(Homo sapiens;
synthetic
construct) 		no annotation
no annotation 		4 LYS A  18
LEU A  20
GLU A  21
LEU B  21
 None
 1.20A 4k4yA-4c7nA:
undetectable		 4k4yA-4c7nA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7n MICROPHTHALMIA
ASSOCIATED
TRANSCRIPTION FACTOR
SYNTHETIC
ALPHA-HELIX, IM10

(Homo sapiens;
synthetic
construct) 		no annotation
no annotation 		4 LYS B  26
LEU B  25
GLU B  22
LEU A  20
 None
 1.29A 4k4yA-4c7nB:
undetectable		 4k4yA-4c7nB:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2o PER-2 BETA-LACTAMASE

(Citrobacter
freundii) 		PF13354
(Beta-lactamase2) 		4 LYS A 293
LEU A 294
GLU A 290
LEU A 252
 None
 1.24A 4k4yA-4d2oA:
undetectable		 4k4yA-4d2oA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp KINESIN-LIKE PROTEIN
KAR3
SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00225
(Kinesin)
PF16796
(Microtub_bd) 		4 LEU B 322
GLU B 323
LEU A 334
LYS A 331
 None
 1.24A 4k4yA-4etpB:
undetectable		 4k4yA-4etpB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		4 LYS A 515
LEU A 514
GLU A 518
LEU A 480
 None
 1.24A 4k4yA-4fajA:
undetectable		 4k4yA-4fajA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 LEU A 719
GLU A 786
LEU A 715
LYS A 713
 None
 1.34A 4k4yA-4gfhA:
undetectable		 4k4yA-4gfhA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpz DTALE2

(Xanthomonas) 		PF03377
(TAL_effector) 		4 LYS A 372
LEU A 375
GLU A 376
LEU A 347
 None
 1.24A 4k4yA-4hpzA:
undetectable		 4k4yA-4hpzA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		4 LYS A 782
LEU A 781
GLU A 863
LEU A 864
 IOD  A1008 ( 4.1A)
None
None
None
 1.24A 4k4yA-4ifqA:
2.3		 4k4yA-4ifqA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is8 NUCLEAR RECEPTOR
SUBFAMILY 5 GROUP A
MEMBER 2

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LYS A 370
LEU A 369
GLU A 368
LEU A 469
 None
 1.35A 4k4yA-4is8A:
0.7		 4k4yA-4is8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1s POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 LEU A   3
GLU A   1
LEU A 416
LYS A 420
 None
 1.26A 4k4yA-4j1sA:
undetectable		 4k4yA-4j1sA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		4 LYS A 179
LEU A 180
GLU A 176
LEU A 306
 None
 1.37A 4k4yA-4jccA:
undetectable		 4k4yA-4jccA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqg MITROCOMIN

(Mitrocoma
cellularia) 		PF13202
(EF-hand_5) 		4 LYS A  99
LEU A 102
GLU A 103
LEU A  11
 None
 1.33A 4k4yA-4nqgA:
undetectable		 4k4yA-4nqgA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 LYS A 574
LEU A 575
GLU A 571
LEU A 554
 None
 1.34A 4k4yA-4po0A:
undetectable		 4k4yA-4po0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfv ANK-N5C-281

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LYS A  88
LEU A  89
GLU A  85
LEU A  51
LYS A  55
 None
 1.44A 4k4yA-4qfvA:
undetectable		 4k4yA-4qfvA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgt PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 LYS A 177
LEU A 178
GLU A 176
LEU A 228
 None
 1.31A 4k4yA-4rgtA:
undetectable		 4k4yA-4rgtA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqz HSIE1
HSIB1

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF07024
(ImpE)
PF05591
(T6SS_VipA) 		4 LYS A  30
LEU A  35
GLU A  32
LEU B  27
 None
 1.23A 4k4yA-4uqzA:
undetectable		 4k4yA-4uqzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfc EXOSOME COMPLEX
EXONUCLEASE RRP6
EXOSOME COMPLEX
PROTEIN LRP1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF08066
(PMC2NT)
PF04000
(Sas10_Utp3) 		4 LYS B  27
LEU B  28
GLU B  24
LEU A   9
 None
 1.11A 4k4yA-4wfcB:
undetectable		 4k4yA-4wfcB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wss HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LYS A 102
LEU A 101
GLU A  58
LEU A  95
 None
 1.15A 4k4yA-4wssA:
undetectable		 4k4yA-4wssA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xul MG662

(Megavirus
chiliensis) 		no annotation 4 LYS A  83
LEU A  84
GLU A  80
LEU A  39
 None
 1.02A 4k4yA-4xulA:
undetectable		 4k4yA-4xulA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 LYS A 216
LEU A 212
GLU A 211
LYS A 162
 None
 1.23A 4k4yA-4y21A:
undetectable		 4k4yA-4y21A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 LYS A 214
LEU A 216
GLU A 217
LEU A 225
 None
 1.29A 4k4yA-4zi6A:
undetectable		 4k4yA-4zi6A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjd AGGREGATION
SUPPRESSING PROTEIN

(Salmonella
enterica) 		PF00011
(HSP20) 		4 LYS A 120
LEU A 127
GLU A 129
LEU A  55
 None
 1.25A 4k4yA-4zjdA:
undetectable		 4k4yA-4zjdA:
15.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		5 LYS A  96
LEU A  97
GLU A  98
LEU A 138
LYS A 142
 None
 0.67A 4k4yA-4zpdA:
57.5		 4k4yA-4zpdA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 4 LYS A 486
LEU A 484
GLU A 483
LEU A 593
 None
 1.37A 4k4yA-5b2oA:
undetectable		 4k4yA-5b2oA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N)
PF17147
(PFOR_II) 		4 LYS A 536
LEU A 534
GLU A 533
LYS A 612
 None
 1.34A 4k4yA-5b47A:
undetectable		 4k4yA-5b47A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqz HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LYS A 102
LEU A 101
GLU A  58
LEU A  95
 None
 1.27A 4k4yA-5bqzA:
undetectable		 4k4yA-5bqzA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 LYS A 499
LEU A 500
GLU A 496
LEU A 332
 None
 1.34A 4k4yA-5btrA:
undetectable		 4k4yA-5btrA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		4 LYS E 202
LEU E 203
GLU E 199
LEU E 179
 None
 1.34A 4k4yA-5ginE:
undetectable		 4k4yA-5ginE:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h55 MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Kluyveromyces
lactis) 		no annotation 4 LYS A  57
LEU A  91
GLU A  93
LEU A 134
 None
 1.22A 4k4yA-5h55A:
undetectable		 4k4yA-5h55A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hi9 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF12796
(Ank_2) 		4 LYS A 602
LEU A 600
GLU A 599
LEU A 555
 None
 1.32A 4k4yA-5hi9A:
undetectable		 4k4yA-5hi9A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irr SEPTIN-LIKE PROTEIN

(Chlamydomonas
reinhardtii) 		PF00735
(Septin) 		4 LYS A 253
LEU A 251
GLU A 250
LEU A 193
 None
 1.24A 4k4yA-5irrA:
undetectable		 4k4yA-5irrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwz SYNAPTONEMAL COMPLEX
PROTEIN 2

(Mus musculus) 		no annotation 4 LYS A 174
LEU A 173
GLU A 214
LEU A 215
 None
 1.23A 4k4yA-5iwzA:
2.4		 4k4yA-5iwzA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Kribbella
flavida) 		PF13416
(SBP_bac_8) 		4 LYS A 332
LEU A 333
GLU A 329
LEU A  47
 None
 1.30A 4k4yA-5ixpA:
undetectable		 4k4yA-5ixpA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		4 LYS A 422
LEU A 423
GLU A 270
LEU A 274
 None
TOX  A 111 ( 4.5A)
None
HEM  A 801 (-4.1A)
 1.32A 4k4yA-5kqiA:
undetectable		 4k4yA-5kqiA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nuv AUTOPHAGY-RELATED
PROTEIN 16-1

(Homo sapiens) 		PF00400
(WD40) 		4 LYS A 359
LEU A 348
GLU A 350
LEU A 336
 None
 1.27A 4k4yA-5nuvA:
undetectable		 4k4yA-5nuvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t76 ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF02272
(DHHA1) 		4 LYS A 120
LEU A 121
GLU A 117
LEU A  86
 None
 1.32A 4k4yA-5t76A:
2.1		 4k4yA-5t76A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F

(Yersinia pestis) 		PF00497
(SBP_bac_3) 		4 LYS A  72
LEU A  70
GLU A  69
LEU A 260
 None
 1.09A 4k4yA-5uh0A:
undetectable		 4k4yA-5uh0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LYS A  88
LEU A  87
GLU A 274
LEU A 273
 None
 1.23A 4k4yA-5uv2A:
1.6		 4k4yA-5uv2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 4 LYS A 632
LEU A 633
GLU A 629
LEU A 586
 None
 1.08A 4k4yA-5vanA:
undetectable		 4k4yA-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwo ESSENTIAL NUCLEAR
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF05291
(Bystin) 		4 LYS A 264
LEU A 265
GLU A 261
LEU A 229
 None
 1.06A 4k4yA-5wwoA:
2.1		 4k4yA-5wwoA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN SA
40S RIBOSOMAL
PROTEIN S21

(Trichomonas
vaginalis;
Trichomonas
vaginalis) 		PF00318
(Ribosomal_S2)
PF01249
(Ribosomal_S21e) 		4 LYS A  57
LEU A  58
GLU A  54
LEU V  78
 None
 1.12A 4k4yA-5xyiA:
undetectable		 4k4yA-5xyiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejj WLAC PROTEIN

(Campylobacter
jejuni) 		no annotation 4 LYS A 352
LEU A 353
GLU A 349
LEU A 164
 None
 1.09A 4k4yA-6ejjA:
undetectable		 4k4yA-6ejjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 LYS A 176
LEU A 177
GLU A 173
LEU A 144
 None
 1.06A 4k4yA-6eroA:
undetectable		 4k4yA-6eroA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erq DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 LYS F 236
LEU F 237
GLU F 233
LEU F 204
 None
 1.03A 4k4yA-6erqF:
undetectable		 4k4yA-6erqF:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai ESSENTIAL NUCLEAR
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 LYS i 264
LEU i 265
GLU i 261
LEU i 229
 C  21216 ( 4.8A)
None
None
None
 1.17A 4k4yA-6faii:
1.8		 4k4yA-6faii:
undetectable