SIMILAR PATTERNS OF AMINO ACIDS FOR 4K39_A_SAMA504_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ak0 | P1 NUCLEASE (Penicilliumcitrinum) |
PF02265(S1-P1_nuclease) | 5 | TYR A 237PHE A 141GLN A 123VAL A 241ILE A 245 | None | 1.18A | 4k39A-1ak0A:undetectable | 4k39A-1ak0A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d9z | EXCINUCLEASE UVRABCCOMPONENT UVRB ([Bacillus]caldotenax) |
PF00271(Helicase_C)PF04851(ResIII)PF12344(UvrB) | 5 | PHE A 379ASN A 387LEU A 61VAL A 337ILE A 63 | None | 1.25A | 4k39A-1d9zA:undetectable | 4k39A-1d9zA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eqf | RNA POLYMERASE IITRANSCRIPTIONINITIATION FACTOR (Homo sapiens) |
PF00439(Bromodomain) | 5 | ASN A1455SER A1456LEU A1466ILE A1469LEU A1399 | None | 1.29A | 4k39A-1eqfA:undetectable | 4k39A-1eqfA:24.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hg8 | ENDOPOLYGALACTURONASE (Fusariumverticillioides) |
PF00295(Glyco_hydro_28) | 5 | GLN A 64ASN A 65SER A 67VAL A 69ILE A 45 | NoneNAG A1374 (-2.5A)NoneNoneNone | 1.32A | 4k39A-1hg8A:undetectable | 4k39A-1hg8A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kl7 | THREONINE SYNTHASE (Saccharomycescerevisiae) |
PF00291(PALP)PF14821(Thr_synth_N) | 5 | PHE A 339ASN A 365LEU A 351VAL A 378ILE A 382 | None | 1.38A | 4k39A-1kl7A:undetectable | 4k39A-1kl7A:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1krh | BENZOATE1,2-DIOXYGENASEREDUCTASE (Acinetobactersp.) |
PF00111(Fer2)PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | TYR A 271GLU A 233GLN A 258LEU A 226ILE A 222 | None | 1.23A | 4k39A-1krhA:undetectable | 4k39A-1krhA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mor | GLUCOSAMINE6-PHOSPHATE SYNTHASE (Escherichiacoli) |
PF01380(SIS) | 5 | PHE A 314ASN A 305SER A 303ILE A 373LEU A 415 | NoneNoneG6P A 609 (-2.7A)NoneNone | 1.39A | 4k39A-1morA:undetectable | 4k39A-1morA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ozh | ACETOLACTATESYNTHASE, CATABOLIC (Klebsiellapneumoniae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLU A 438ASN A 436LEU A 434ILE A 430LEU A 426 | None | 1.39A | 4k39A-1ozhA:undetectable | 4k39A-1ozhA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pdu | NUCLEAR HORMONERECEPTOR HR38 (Drosophilamelanogaster) |
PF00104(Hormone_recep) | 5 | PHE A 359GLU A 434GLN A 521ASN A 437VAL A 401 | None | 1.44A | 4k39A-1pduA:undetectable | 4k39A-1pduA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qu2 | ISOLEUCYL-TRNASYNTHETASE (Staphylococcusaureus) |
PF00133(tRNA-synt_1)PF06827(zf-FPG_IleRS)PF08264(Anticodon_1) | 5 | GLU A 707ARG A 684LEU A 685ILE A 748LEU A 721 | NoneNoneNoneNone A T 35 ( 4.6A) | 1.21A | 4k39A-1qu2A:undetectable | 4k39A-1qu2A:16.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rpw | TRANSCRIPTIONALREGULATOR QACR (Staphylococcusaureus) |
PF00440(TetR_N)PF08360(TetR_C_5) | 5 | GLU A 101ASN A 21LEU A 14ILE A 28LEU A 39 | None | 1.43A | 4k39A-1rpwA:undetectable | 4k39A-1rpwA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1srq | GTPASE-ACTIVATINGPROTEIN 1 (Homo sapiens) |
PF02145(Rap_GAP) | 5 | ASN A 312SER A 311LEU A 314ILE A 288LEU A 272 | None | 1.40A | 4k39A-1srqA:undetectable | 4k39A-1srqA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tv8 | MOLYBDENUM COFACTORBIOSYNTHESIS PROTEINA (Staphylococcusaureus) |
PF04055(Radical_SAM)PF06463(Mob_synth_C)PF13394(Fer4_14) | 6 | TYR A 30GLU A 76ASN A 104SER A 126VAL A 167ILE A 194 | SAM A1501 ( 4.5A)SAM A1501 (-4.4A)SF4 A1401 ( 4.4A)SAM A1501 ( 2.4A)SAM A1501 (-4.5A)DTU A1502 ( 4.7A) | 0.96A | 4k39A-1tv8A:18.6 | 4k39A-1tv8A:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wod | MODA (Escherichiacoli) |
PF13531(SBP_bac_11) | 5 | TYR A 213PHE A 212LEU A 81VAL A 198ILE A 56 | None | 1.25A | 4k39A-1wodA:undetectable | 4k39A-1wodA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yzy | HYPOTHETICAL PROTEINHI1011 (Haemophilusinfluenzae) |
PF07005(DUF1537)PF17042(DUF1357_C) | 5 | PHE A 122ASN A 200SER A 201VAL A 171ILE A 172 | None | 0.95A | 4k39A-1yzyA:undetectable | 4k39A-1yzyA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zy9 | ALPHA-GALACTOSIDASE (Thermotogamaritima) |
PF02065(Melibiase) | 5 | PHE A 348ASN A 176VAL A 379ILE A 365LEU A 329 | None | 1.32A | 4k39A-1zy9A:3.0 | 4k39A-1zy9A:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ahw | PUTATIVE ENZYME YDIF (Escherichiacoli) |
PF01144(CoA_trans) | 5 | TYR A 466LEU A 462VAL A 464ILE A 412LEU A 376 | NoneNoneNoneNoneCOA A2600 (-4.9A) | 1.45A | 4k39A-2ahwA:undetectable | 4k39A-2ahwA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2az4 | HYPOTHETICAL PROTEINEF2904 (Enterococcusfaecalis) |
PF12706(Lactamase_B_2) | 5 | PHE A 293GLU A 282ASN A 284LEU A 123ILE A 119 | None | 1.09A | 4k39A-2az4A:undetectable | 4k39A-2az4A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2az4 | HYPOTHETICAL PROTEINEF2904 (Enterococcusfaecalis) |
PF12706(Lactamase_B_2) | 5 | PHE A 293GLU A 282ASN A 284SER A 122LEU A 123 | None | 1.25A | 4k39A-2az4A:undetectable | 4k39A-2az4A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1i | PEPTIDOGLYCAN GLCNACDEACETYLASE (Streptococcuspneumoniae) |
PF01522(Polysacc_deac_1) | 5 | TYR A 439PHE A 441VAL A 408ILE A 404LEU A 272 | None | 1.43A | 4k39A-2c1iA:undetectable | 4k39A-2c1iA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ch1 | 3-HYDROXYKYNURENINETRANSAMINASE (Anophelesgambiae) |
PF00266(Aminotran_5) | 5 | GLU A 252ASN A 245LEU A 240ILE A 216LEU A 60 | None | 1.38A | 4k39A-2ch1A:undetectable | 4k39A-2ch1A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d7d | UVRABC SYSTEMPROTEIN B (Bacillussubtilis) |
PF00271(Helicase_C)PF02151(UVR)PF04851(ResIII)PF12344(UvrB) | 5 | PHE A 379ASN A 388LEU A 61VAL A 337ILE A 63 | None | 1.38A | 4k39A-2d7dA:undetectable | 4k39A-2d7dA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f3j | RNA AND EXPORTFACTOR BINDINGPROTEIN 2 (Mus musculus) |
PF00076(RRM_1)PF07078(FYTT) | 5 | PHE A 98GLN A 148LEU A 78VAL A 120LEU A 94 | None | 1.33A | 4k39A-2f3jA:undetectable | 4k39A-2f3jA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gjt | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE PTPRO (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | TYR A 997GLN A1027LEU A 981VAL A 979ILE A 993 | None | 1.20A | 4k39A-2gjtA:undetectable | 4k39A-2gjtA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwo | DUAL SPECIFICITYPROTEIN PHOSPHATASE13 (Homo sapiens) |
PF00782(DSPc) | 5 | ASN A 44LEU A 55VAL A 142ILE A 174LEU A 35 | None | 1.22A | 4k39A-2gwoA:undetectable | 4k39A-2gwoA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h8q | RED FLUORESCENTPROTEIN DRFP583 (Discosoma sp.) |
PF01353(GFP) | 5 | PHE A 56GLN A 213LEU A 46VAL A 48ILE A 29 | NoneCRQ A 66 ( 3.9A)NoneNoneNone | 1.23A | 4k39A-2h8qA:undetectable | 4k39A-2h8qA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hv2 | HYPOTHETICAL PROTEIN (Enterococcusfaecalis) |
PF13527(Acetyltransf_9)PF13530(SCP2_2) | 5 | PHE A 68TYR A 295LEU A 288ILE A 285LEU A 358 | None | 1.30A | 4k39A-2hv2A:undetectable | 4k39A-2hv2A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i75 | TYROSINE-PROTEINPHOSPHATASENON-RECEPTOR TYPE 4 (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | TYR A 709GLN A 739LEU A 698VAL A 696ILE A 705 | None | 1.14A | 4k39A-2i75A:undetectable | 4k39A-2i75A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ny0 | ENVELOPEGLYCOPROTEIN GP120 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 5 | PHE A 391ASN A 332VAL A 292ILE A 449LEU A 452 | None | 1.38A | 4k39A-2ny0A:undetectable | 4k39A-2ny0A:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o1s | 1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE (Escherichiacoli) |
PF02779(Transket_pyr)PF02780(Transketolase_C)PF13292(DXP_synthase_N) | 5 | PHE A 277ASN A 268LEU A 262ILE A 280LEU A 178 | None | 1.36A | 4k39A-2o1sA:undetectable | 4k39A-2o1sA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oc6 | YDHG PROTEIN (Bacillussubtilis) |
PF08818(DUF1801) | 5 | TYR A 100LEU A 62VAL A 98ILE A 92LEU A 102 | GOL A 130 ( 3.8A)NoneNoneNoneNone | 1.26A | 4k39A-2oc6A:undetectable | 4k39A-2oc6A:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q9u | A-TYPE FLAVOPROTEIN (Giardiaintestinalis) |
no annotation | 5 | TYR A 332TYR A 33GLU A 87LEU A 204LEU A 303 | NoneNoneFEO A 701 (-2.9A)NoneNone | 1.40A | 4k39A-2q9uA:undetectable | 4k39A-2q9uA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rq4 | CUG-BP- ANDETR-3-LIKE FACTOR 1 (Homo sapiens) |
PF00076(RRM_1) | 5 | TYR A 449GLU A 396LEU A 476VAL A 474ILE A 459 | None | 1.03A | 4k39A-2rq4A:undetectable | 4k39A-2rq4A:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vad | RED FLUORESCENTPROTEIN (Discosoma sp.) |
PF01353(GFP) | 5 | PHE A 56GLN A 213LEU A 46VAL A 48ILE A 29 | NoneCRQ A 66 ( 3.8A)NoneNoneNone | 1.22A | 4k39A-2vadA:undetectable | 4k39A-2vadA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cgl | GFP-LIKE FLUORESCENTCHROMOPROTEINDSFP483 (Discosomastriata) |
PF01353(GFP) | 5 | PHE A 56ASN A 205LEU A 46VAL A 48ILE A 29 | None | 0.68A | 4k39A-3cglA:undetectable | 4k39A-3cglA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cpi | RAB GDP-DISSOCIATIONINHIBITOR (Saccharomycescerevisiae) |
PF00996(GDI) | 5 | TYR G 234PHE G 110ASN G 81SER G 50LEU G 89 | None | 1.42A | 4k39A-3cpiG:undetectable | 4k39A-3cpiG:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d4j | DIPHOSPHOMEVALONATEDECARBOXYLASE (Homo sapiens) |
PF00288(GHMP_kinases_N) | 5 | TYR A 131SER A 114VAL A 112ILE A 65LEU A 83 | None | 1.21A | 4k39A-3d4jA:undetectable | 4k39A-3d4jA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqn | GLUCAN1,3-BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF12708(Pectate_lyase_3) | 5 | TYR A 94PHE A 156GLN A 23VAL A 46LEU A 108 | None | 1.39A | 4k39A-3eqnA:undetectable | 4k39A-3eqnA:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fzq | PUTATIVE HYDROLASE (Clostridioidesdifficile) |
PF08282(Hydrolase_3) | 5 | PHE A 221LEU A 58VAL A 40ILE A 30LEU A 267 | None | 1.42A | 4k39A-3fzqA:undetectable | 4k39A-3fzqA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j70 | ENVELOPEGLYCOPROTEIN GP120 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 5 | PHE D 391ASN D 332VAL D 292ILE D 449LEU D 452 | None | 1.37A | 4k39A-3j70D:undetectable | 4k39A-3j70D:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ja6 | CHEMOTAXIS PROTEINCHEW (Escherichiacoli) |
PF01584(CheW) | 5 | GLU A 17SER A 15LEU A 102ILE A 104LEU A 109 | None | 1.41A | 4k39A-3ja6A:undetectable | 4k39A-3ja6A:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jwo | HIV-1 GP120 ENVELOPEGLYCOPROTEIN (Homo sapiens) |
PF00516(GP120) | 5 | PHE A 391ASN A 332VAL A 292ILE A 449LEU A 452 | None | 1.44A | 4k39A-3jwoA:undetectable | 4k39A-3jwoA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k4x | PROLIFERATING CELLNUCLEAR ANTIGEN (Saccharomycescerevisiae) |
PF00705(PCNA_N)PF02747(PCNA_C) | 5 | PHE A 741GLU A 677LEU A 731ILE A 696LEU A 739 | None | 1.33A | 4k39A-3k4xA:undetectable | 4k39A-3k4xA:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lsp | DEST (Pseudomonasaeruginosa) |
PF00440(TetR_N) | 5 | PHE A 96GLU A 66SER A 105LEU A 108ILE A 173 | OLA A 221 ( 4.6A)NoneSO4 A 222 ( 4.4A)NoneNone | 1.41A | 4k39A-3lspA:undetectable | 4k39A-3lspA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nlc | UNCHARACTERIZEDPROTEIN VP0956 (Vibrioparahaemolyticus) |
no annotation | 5 | PHE A 72GLU A 6LEU A 57ILE A 59LEU A 68 | None | 1.27A | 4k39A-3nlcA:undetectable | 4k39A-3nlcA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q1x | SERINEACETYLTRANSFERASE (Entamoebahistolytica) |
PF00132(Hexapep) | 5 | GLU A 153LEU A 142VAL A 89ILE A 92LEU A 65 | None | 1.41A | 4k39A-3q1xA:undetectable | 4k39A-3q1xA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3h | HMW1C-LIKEGLYCOSYLTRANSFERASE (Actinobacilluspleuropneumoniae) |
no annotation | 5 | GLU A 580ASN A 577VAL A 461ILE A 433LEU A 450 | None | 1.40A | 4k39A-3q3hA:2.5 | 4k39A-3q3hA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5s | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Sorangiumcellulosum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLU A 61LEU A 36VAL A 38ILE A 12LEU A 371 | None | 1.29A | 4k39A-3s5sA:3.9 | 4k39A-3s5sA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqg | METHYL-COENZYME MREDUCTASE, GAMMASUBUNIT (unculturedarchaeon) |
PF02240(MCR_gamma) | 5 | PHE C 93GLN C 226ARG C 15VAL C 11LEU C 211 | None | 1.43A | 4k39A-3sqgC:undetectable | 4k39A-3sqgC:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tyg | ENVELOPEGLYCOPROTEIN GP160 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 5 | PHE A 180ASN A 121VAL A 95ILE A 19LEU A 22 | NoneNAG A 200 (-1.9A)NoneNoneNone | 1.32A | 4k39A-3tygA:undetectable | 4k39A-3tygA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uau | SURFACE-EXPOSEDLIPOPROTEIN (Campylobacterjejuni) |
PF16668(JLPA) | 5 | PHE A 221TYR A 115GLN A 123ILE A 101LEU A 226 | None | 1.41A | 4k39A-3uauA:undetectable | 4k39A-3uauA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vps | NAD-DEPENDENTEPIMERASE/DEHYDRATASE (Streptomyceschartreusis) |
PF01370(Epimerase) | 5 | GLU A 133GLN A 278ASN A 233VAL A 216LEU A 23 | None | 1.30A | 4k39A-3vpsA:undetectable | 4k39A-3vpsA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vse | PUTATIVEUNCHARACTERIZEDPROTEIN (Staphylococcusaureus) |
PF10672(Methyltrans_SAM) | 5 | PHE A 256GLU A 180ASN A 181ARG A 209LEU A 208 | None | 1.42A | 4k39A-3vseA:undetectable | 4k39A-3vseA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0q | RESTRICTIONENDONUCLEASE (Mycobacteriumsp. JLS) |
PF04471(Mrr_cat) | 5 | PHE A 335GLU A 451ARG A 376LEU A 377VAL A 373 | None | 1.31A | 4k39A-4f0qA:undetectable | 4k39A-4f0qA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f1n | KPAGO (Vanderwaltozymapolyspora) |
PF02171(Piwi) | 5 | PHE A 392TYR A 277ASN A 329LEU A 428ILE A 274 | None | 1.32A | 4k39A-4f1nA:undetectable | 4k39A-4f1nA:16.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h1g | MALTOSE BINDINGPROTEIN-CAKAR3 MOTORDOMAIN FUSIONPROTEIN (Escherichiacoli;Candidaalbicans) |
PF00225(Kinesin)PF13416(SBP_bac_8) | 5 | PHE A 565ASN A 435SER A 430LEU A 431ILE A 467 | None | 1.33A | 4k39A-4h1gA:undetectable | 4k39A-4h1gA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h65 | PYRIMIDINE PRECURSORBIOSYNTHESIS ENZYMETHI5 (Saccharomycescerevisiae) |
PF09084(NMT1) | 5 | GLU A 325GLN A 165ARG A 186ILE A 160LEU A 84 | None | 1.34A | 4k39A-4h65A:undetectable | 4k39A-4h65A:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hfn | ALLYL ALCOHOLDEHYDROGENASE (Nicotianatabacum) |
PF00107(ADH_zinc_N)PF16884(ADH_N_2) | 5 | TYR A 294TYR A 130GLU A 311VAL A 298ILE A 299 | None | 1.24A | 4k39A-4hfnA:undetectable | 4k39A-4hfnA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jjj | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Thermobifidafusca) |
PF02011(Glyco_hydro_48) | 5 | TYR A 265GLN A 91ASN A 141ARG A 316LEU A 263 | None | 1.41A | 4k39A-4jjjA:undetectable | 4k39A-4jjjA:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jz5 | GP26 (Listeria phageP40) |
PF01183(Glyco_hydro_25) | 5 | TYR A 16GLU A 39VAL A 14ILE A 182LEU A 5 | None | 1.44A | 4k39A-4jz5A:3.7 | 4k39A-4jz5A:20.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k37 | ANAEROBICSULFATASE-MATURATINGENZYME (Clostridiumperfringens) |
PF04055(Radical_SAM)PF13186(SPASM)PF13353(Fer4_12) | 7 | TYR A 21PHE A 23GLN A 98LEU A 163VAL A 165ILE A 192LEU A 195 | SAM A 504 (-4.6A)SAM A 504 (-4.2A)SAM A 504 (-4.4A)SAM A 504 (-3.8A)SAM A 504 (-4.7A)SAM A 504 (-4.0A)SAM A 504 (-4.1A) | 1.06A | 4k39A-4k37A:59.6 | 4k39A-4k37A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k37 | ANAEROBICSULFATASE-MATURATINGENZYME (Clostridiumperfringens) |
PF04055(Radical_SAM)PF13186(SPASM)PF13353(Fer4_12) | 11 | TYR A 21PHE A 23TYR A 24GLU A 67ASN A 100SER A 122ARG A 134LEU A 163VAL A 165ILE A 192LEU A 195 | SAM A 504 (-4.6A)SAM A 504 (-4.2A)SAM A 504 ( 3.4A)SAM A 504 (-4.1A)SF4 A 503 ( 4.2A)SAM A 504 (-2.5A)SAM A 504 ( 3.5A)SAM A 504 (-3.8A)SAM A 504 (-4.7A)SAM A 504 (-4.0A)SAM A 504 (-4.1A) | 0.30A | 4k39A-4k37A:59.6 | 4k39A-4k37A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kf5 | FLUORESCENT PROTEINSFCHERRY+GFP10-11 (syntheticconstruct) |
PF01353(GFP) | 5 | PHE C 56GLN C 253LEU C 46VAL C 48ILE C 29 | NoneCH6 C 66 ( 4.7A)NoneNoneNone | 1.16A | 4k39A-4kf5C:undetectable | 4k39A-4kf5C:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4maa | PUTATIVEBRANCHED-CHAIN AMINOACID ABCTRANSPORTER,PERIPLASMIC AMINOACID-BINDING PROTEIN (Pseudomonasprotegens) |
PF13458(Peripla_BP_6) | 5 | PHE A 32GLN A 101SER A 55VAL A 59LEU A 65 | None | 1.27A | 4k39A-4maaA:undetectable | 4k39A-4maaA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nfu | EDS1SENESCENCE-ASSOCIATED CARBOXYLESTERASE101 (Arabidopsisthaliana;Arabidopsisthaliana) |
PF01764(Lipase_3)PF01764(Lipase_3) | 5 | PHE A 295TYR A 296GLN A 356LEU B 7VAL A 244 | None | 1.45A | 4k39A-4nfuA:undetectable | 4k39A-4nfuA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pfw | ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN (Thermotogamaritima) |
PF00496(SBP_bac_5) | 5 | GLU A 77LEU A 103VAL A 108ILE A 162LEU A 160 | None | 1.39A | 4k39A-4pfwA:undetectable | 4k39A-4pfwA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4psp | ALPHA-FUCOSIDASEGH29 (Fusariumgraminearum) |
PF01120(Alpha_L_fucos)PF16757(Fucosidase_C) | 5 | ASN A 433LEU A 471VAL A 429ILE A 473LEU A 450 | NoneNoneTRS A 618 (-3.9A)NoneNone | 1.33A | 4k39A-4pspA:2.9 | 4k39A-4pspA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rx4 | HIV-1 CLADE AQ842.D12 GP120 (Humanimmunodeficiencyvirus 1) |
no annotation | 5 | PHE G 391ASN G 332VAL G 292ILE G 449LEU G 452 | NoneNAG G 502 (-4.3A)NoneNoneNone | 1.42A | 4k39A-4rx4G:undetectable | 4k39A-4rx4G:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v19 | MITORIBOSOMALPROTEIN BL31M,MRPL55 (Sus scrofa) |
PF09776(Mitoc_L55) | 5 | ARG 4 73LEU 4 57VAL 4 55ILE 4 67LEU 4 52 | None | 1.24A | 4k39A-4v194:undetectable | 4k39A-4v194:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v39 | SIALYLTRANSFERASE (Pasteurelladagmatis) |
PF11477(PM0188) | 5 | TYR A 170GLN A 165SER A 164VAL A 168LEU A 81 | None | 1.40A | 4k39A-4v39A:2.3 | 4k39A-4v39A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvs | DONOR 45 01DG5 COREEGP120 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 5 | PHE G 391ASN G 332VAL G 292ILE G 449LEU G 452 | NoneNAG G 602 (-4.0A)NoneNoneNone | 1.42A | 4k39A-4xvsG:undetectable | 4k39A-4xvsG:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ydi | ENVELOPEGLYCOPROTEIN GP160 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 5 | PHE G 391ASN G 332VAL G 292ILE G 449LEU G 452 | NoneNAG G 505 (-1.9A)NoneNoneNone | 1.24A | 4k39A-4ydiG:undetectable | 4k39A-4ydiG:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ye4 | HT593.1 GP120 (Humanimmunodeficiencyvirus) |
PF00516(GP120) | 5 | PHE G 391ASN G 332VAL G 292ILE G 449LEU G 452 | NoneNAG G 505 (-4.4A)NoneNoneNone | 1.36A | 4k39A-4ye4G:undetectable | 4k39A-4ye4G:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a7x | HIV-1 YU2 GP120 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 5 | PHE A 391ASN A 332VAL A 292ILE A 449LEU A 452 | None | 1.42A | 4k39A-5a7xA:undetectable | 4k39A-5a7xA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d3i | STAPHYLOCOCCALSUPERANTIGEN-LIKEPROTEIN 3 (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 5 | TYR B 278GLU B 273LEU B 267VAL B 323ILE B 286 | None | 1.28A | 4k39A-5d3iB:undetectable | 4k39A-5d3iB:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e3v | ADENYLOSUCCINATELYASE (Salmonellaenterica) |
PF00206(Lyase_1)PF08328(ASL_C) | 5 | ASN A 313SER A 317LEU A 321ILE A 261LEU A 144 | None | 1.17A | 4k39A-5e3vA:undetectable | 4k39A-5e3vA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f4l | ENVELOPEGLYCOPROTEIN GP120OF HIV-1 CLADE C (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 5 | PHE A 391ASN A 332VAL A 292ILE A 449LEU A 452 | None | 1.33A | 4k39A-5f4lA:undetectable | 4k39A-5f4lA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmf | TRANSCRIPTIONINITIATION FACTORIIE SUBUNIT BETA,TFA2TRANSCRIPTIONINITIATION FACTORIIF SUBUNIT BETA,TFG2 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF02186(TFIIE_beta)PF02270(TFIIF_beta) | 5 | PHE V 307SER S 152ARG V 352VAL V 336LEU V 303 | None | 1.37A | 4k39A-5fmfV:undetectable | 4k39A-5fmfV:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i4d | SUPERANTIGEN-LIKEPROTEIN (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 5 | TYR A 308GLU A 303LEU A 297VAL A 353ILE A 316 | None | 1.34A | 4k39A-5i4dA:undetectable | 4k39A-5i4dA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ihe | DNA POLYMERASE IISMALL SUBUNIT (Pyrococcusabyssi) |
PF00149(Metallophos) | 5 | GLN A 557SER A 577LEU A 357VAL A 599LEU A 380 | None | 1.43A | 4k39A-5iheA:undetectable | 4k39A-5iheA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1g | 1-CYS PEROXIREDOXIN (Vibriovulnificus) |
PF08534(Redoxin) | 5 | GLU A 151ASN A 149LEU A 53ILE A 94LEU A 70 | None | 1.38A | 4k39A-5k1gA:undetectable | 4k39A-5k1gA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8f | ACETYL-COENZYME ASYNTHETASE (Cryptococcusneoformans) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 5 | PHE A 285TYR A 306ASN A 107LEU A 346ILE A 342 | None | 1.37A | 4k39A-5k8fA:undetectable | 4k39A-5k8fA:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m3l | EXTRACELLULARGLOBIN-2 (Lumbricusterrestris) |
PF00042(Globin) | 5 | GLU B 8LEU B 114VAL B 117ILE B 113LEU B 69 | None | 1.37A | 4k39A-5m3lB:undetectable | 4k39A-5m3lB:14.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n2g | DNA POLYMERASE (Vaccinia virus) |
no annotation | 5 | TYR A 697TYR A 550ASN A 785VAL A 782ILE A 778 | None | 1.43A | 4k39A-5n2gA:undetectable | 4k39A-5n2gA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5of4 | GENERALTRANSCRIPTION FACTORIIH SUBUNIT 2 (Homo sapiens) |
PF04056(Ssl1) | 5 | PHE E 91TYR E 95ASN E 123LEU E 120LEU E 168 | None | 1.35A | 4k39A-5of4E:undetectable | 4k39A-5of4E:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ujs | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Campylobacterjejuni) |
PF00275(EPSP_synthase) | 5 | PHE A 157ASN A 23LEU A 193ILE A 169LEU A 181 | None | 1.34A | 4k39A-5ujsA:undetectable | 4k39A-5ujsA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5um8 | GLYCOPROTEIN GP120 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 5 | PHE G 391ASN G 332VAL G 292ILE G 449LEU G 452 | NoneNAG G 728 (-1.8A)NoneNoneNone | 1.29A | 4k39A-5um8G:undetectable | 4k39A-5um8G:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v1s | RADICAL SAM (Streptococcussuis) |
PF04055(Radical_SAM)PF13394(Fer4_14) | 5 | PHE A 125GLU A 161ASN A 187SER A 210VAL A 249 | SAM A 604 (-4.8A)SAM A 604 (-4.4A)SF4 A 601 (-4.4A)SAM A 604 (-2.4A)SAM A 604 (-4.2A) | 0.71A | 4k39A-5v1sA:23.3 | 4k39A-5v1sA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vsl | RADICAL S-ADENOSYLMETHIONINEDOMAIN-CONTAININGPROTEIN 2 (Mus musculus) |
PF04055(Radical_SAM)PF13353(Fer4_12) | 5 | GLU A 127ASN A 158SER A 180VAL A 224LEU A 252 | SAH A 402 (-4.3A)SF4 A 401 ( 4.3A)SAH A 402 (-2.4A)SAH A 402 (-4.3A)SAH A 402 (-4.5A) | 0.51A | 4k39A-5vslA:19.2 | 4k39A-5vslA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wgg | RADICAL SAM DOMAINPROTEIN (Ruminiclostridiumthermocellum) |
PF04055(Radical_SAM)PF13186(SPASM)PF13353(Fer4_12) | 5 | TYR A 110GLU A 155ASN A 188SER A 210ARG A 222 | SAM A 504 (-4.8A)SAM A 504 (-3.7A)SF4 A 502 ( 4.3A)SAM A 504 (-2.5A)SF4 A 502 ( 3.6A) | 0.21A | 4k39A-5wggA:31.1 | 4k39A-5wggA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | DNA-DIRECTED RNAPOLYMERASE SUBUNITRNA POLYMERASE IITHIRD LARGESTSUBUNIT B44, PART OFCENTRAL CORERNA POLYMERASE IISUBUNIT B12.5 (Komagataellaphaffii;Komagataellaphaffii;Komagataellaphaffii) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4)PF01000(RNA_pol_A_bac)PF01193(RNA_pol_L)PF13656(RNA_pol_L_2) | 5 | TYR K 53GLU A 545SER C 27LEU K 45ILE K 94 | None | 1.37A | 4k39A-5xogK:undetectable | 4k39A-5xogK:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyu | 30S RIBOSOMALPROTEIN S7 (Mycolicibacteriumsmegmatis) |
PF00177(Ribosomal_S7) | 5 | ASN G 106SER G 108LEU G 120ILE G 42LEU G 38 | C A 922 ( 4.9A)NoneNone U A1221 ( 3.6A) G A1222 ( 4.1A) | 1.26A | 4k39A-5xyuG:undetectable | 4k39A-5xyuG:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y9d | ACYL-COENZYME AOXIDASE 1 (Yarrowialipolytica) |
no annotation | 5 | PHE A 627GLU A 16GLN A 619VAL A 24LEU A 31 | None | 1.40A | 4k39A-5y9dA:undetectable | 4k39A-5y9dA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z0u | NEOPULLULANASE 1 (Thermoactinomycesvulgaris) |
no annotation | 5 | GLU A 25SER A 463LEU A 130ILE A 394LEU A 355 | None | 1.44A | 4k39A-5z0uA:3.5 | 4k39A-5z0uA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b0n | ENVELOPEGLYCOPROTEIN GP140 (Humanimmunodeficiencyvirus 1) |
no annotation | 5 | PHE G 391ASN G 332VAL G 292ILE G 449LEU G 452 | NoneNAG G1331 ( 2.0A)NoneNoneNone | 1.26A | 4k39A-6b0nG:undetectable | 4k39A-6b0nG:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b3r | PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT 1 (Mus musculus) |
no annotation | 5 | TYR A2398PHE A2372ASN A2385LEU A2390LEU A2399 | None | 1.39A | 4k39A-6b3rA:undetectable | 4k39A-6b3rA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bnf | PHOSPHOETHANOLAMINETRANSFERASE (Moraxella sp.HMSC061H09) |
no annotation | 5 | PHE A 560GLN A 373LEU A 369ILE A 343LEU A 556 | None | 1.26A | 4k39A-6bnfA:undetectable | 4k39A-6bnfA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bwy | PROTECTION OFTELOMERES PROTEIN 1,DNA DC->DU-EDITING ENZYMEAPOBEC-3G FUSION (Schizosaccharomycespombe;Homo sapiens) |
no annotation | 5 | TYR A 40GLN A 48SER A 52ARG A 51LEU A 185 | None | 1.41A | 4k39A-6bwyA:undetectable | 4k39A-6bwyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dcq | ENVELOPEGLYCOPROTEIN GP160 (Humanimmunodeficiencyvirus 1) |
no annotation | 5 | PHE A 391ASN A 332VAL A 292ILE A 449LEU A 452 | NoneNAG A 603 ( 2.1A)NoneNoneNone | 1.36A | 4k39A-6dcqA:undetectable | 4k39A-6dcqA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fea | NITROGENASE PROTEINALPHA CHAIN (Azotobactervinelandii) |
no annotation | 5 | PHE A 164ARG A 271LEU A 268ILE A 264LEU A 183 | None | 1.43A | 4k39A-6feaA:undetectable | 4k39A-6feaA:undetectable |