SIMILAR PATTERNS OF AMINO ACIDS FOR 4K39_A_SAMA504_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak0 P1 NUCLEASE

(Penicillium
citrinum)
PF02265
(S1-P1_nuclease)
5 TYR A 237
PHE A 141
GLN A 123
VAL A 241
ILE A 245
None
1.18A 4k39A-1ak0A:
undetectable
4k39A-1ak0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB


([Bacillus]
caldotenax)
PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB)
5 PHE A 379
ASN A 387
LEU A  61
VAL A 337
ILE A  63
None
1.25A 4k39A-1d9zA:
undetectable
4k39A-1d9zA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR


(Homo sapiens)
PF00439
(Bromodomain)
5 ASN A1455
SER A1456
LEU A1466
ILE A1469
LEU A1399
None
1.29A 4k39A-1eqfA:
undetectable
4k39A-1eqfA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg8 ENDOPOLYGALACTURONAS
E


(Fusarium
verticillioides)
PF00295
(Glyco_hydro_28)
5 GLN A  64
ASN A  65
SER A  67
VAL A  69
ILE A  45
None
NAG  A1374 (-2.5A)
None
None
None
1.32A 4k39A-1hg8A:
undetectable
4k39A-1hg8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae)
PF00291
(PALP)
PF14821
(Thr_synth_N)
5 PHE A 339
ASN A 365
LEU A 351
VAL A 378
ILE A 382
None
1.38A 4k39A-1kl7A:
undetectable
4k39A-1kl7A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE


(Acinetobacter
sp.)
PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 TYR A 271
GLU A 233
GLN A 258
LEU A 226
ILE A 222
None
1.23A 4k39A-1krhA:
undetectable
4k39A-1krhA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE


(Escherichia
coli)
PF01380
(SIS)
5 PHE A 314
ASN A 305
SER A 303
ILE A 373
LEU A 415
None
None
G6P  A 609 (-2.7A)
None
None
1.39A 4k39A-1morA:
undetectable
4k39A-1morA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC


(Klebsiella
pneumoniae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 GLU A 438
ASN A 436
LEU A 434
ILE A 430
LEU A 426
None
1.39A 4k39A-1ozhA:
undetectable
4k39A-1ozhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdu NUCLEAR HORMONE
RECEPTOR HR38


(Drosophila
melanogaster)
PF00104
(Hormone_recep)
5 PHE A 359
GLU A 434
GLN A 521
ASN A 437
VAL A 401
None
1.44A 4k39A-1pduA:
undetectable
4k39A-1pduA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE


(Staphylococcus
aureus)
PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1)
5 GLU A 707
ARG A 684
LEU A 685
ILE A 748
LEU A 721
None
None
None
None
A  T  35 ( 4.6A)
1.21A 4k39A-1qu2A:
undetectable
4k39A-1qu2A:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpw TRANSCRIPTIONAL
REGULATOR QACR


(Staphylococcus
aureus)
PF00440
(TetR_N)
PF08360
(TetR_C_5)
5 GLU A 101
ASN A  21
LEU A  14
ILE A  28
LEU A  39
None
1.43A 4k39A-1rpwA:
undetectable
4k39A-1rpwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srq GTPASE-ACTIVATING
PROTEIN 1


(Homo sapiens)
PF02145
(Rap_GAP)
5 ASN A 312
SER A 311
LEU A 314
ILE A 288
LEU A 272
None
1.40A 4k39A-1srqA:
undetectable
4k39A-1srqA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A


(Staphylococcus
aureus)
PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14)
6 TYR A  30
GLU A  76
ASN A 104
SER A 126
VAL A 167
ILE A 194
SAM  A1501 ( 4.5A)
SAM  A1501 (-4.4A)
SF4  A1401 ( 4.4A)
SAM  A1501 ( 2.4A)
SAM  A1501 (-4.5A)
DTU  A1502 ( 4.7A)
0.96A 4k39A-1tv8A:
18.6
4k39A-1tv8A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wod MODA

(Escherichia
coli)
PF13531
(SBP_bac_11)
5 TYR A 213
PHE A 212
LEU A  81
VAL A 198
ILE A  56
None
1.25A 4k39A-1wodA:
undetectable
4k39A-1wodA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011


(Haemophilus
influenzae)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 PHE A 122
ASN A 200
SER A 201
VAL A 171
ILE A 172
None
0.95A 4k39A-1yzyA:
undetectable
4k39A-1yzyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima)
PF02065
(Melibiase)
5 PHE A 348
ASN A 176
VAL A 379
ILE A 365
LEU A 329
None
1.32A 4k39A-1zy9A:
3.0
4k39A-1zy9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli)
PF01144
(CoA_trans)
5 TYR A 466
LEU A 462
VAL A 464
ILE A 412
LEU A 376
None
None
None
None
COA  A2600 (-4.9A)
1.45A 4k39A-2ahwA:
undetectable
4k39A-2ahwA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az4 HYPOTHETICAL PROTEIN
EF2904


(Enterococcus
faecalis)
PF12706
(Lactamase_B_2)
5 PHE A 293
GLU A 282
ASN A 284
LEU A 123
ILE A 119
None
1.09A 4k39A-2az4A:
undetectable
4k39A-2az4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az4 HYPOTHETICAL PROTEIN
EF2904


(Enterococcus
faecalis)
PF12706
(Lactamase_B_2)
5 PHE A 293
GLU A 282
ASN A 284
SER A 122
LEU A 123
None
1.25A 4k39A-2az4A:
undetectable
4k39A-2az4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1i PEPTIDOGLYCAN GLCNAC
DEACETYLASE


(Streptococcus
pneumoniae)
PF01522
(Polysacc_deac_1)
5 TYR A 439
PHE A 441
VAL A 408
ILE A 404
LEU A 272
None
1.43A 4k39A-2c1iA:
undetectable
4k39A-2c1iA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE


(Anopheles
gambiae)
PF00266
(Aminotran_5)
5 GLU A 252
ASN A 245
LEU A 240
ILE A 216
LEU A  60
None
1.38A 4k39A-2ch1A:
undetectable
4k39A-2ch1A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B


(Bacillus
subtilis)
PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB)
5 PHE A 379
ASN A 388
LEU A  61
VAL A 337
ILE A  63
None
1.38A 4k39A-2d7dA:
undetectable
4k39A-2d7dA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3j RNA AND EXPORT
FACTOR BINDING
PROTEIN 2


(Mus musculus)
PF00076
(RRM_1)
PF07078
(FYTT)
5 PHE A  98
GLN A 148
LEU A  78
VAL A 120
LEU A  94
None
1.33A 4k39A-2f3jA:
undetectable
4k39A-2f3jA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO


(Homo sapiens)
PF00102
(Y_phosphatase)
5 TYR A 997
GLN A1027
LEU A 981
VAL A 979
ILE A 993
None
1.20A 4k39A-2gjtA:
undetectable
4k39A-2gjtA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwo DUAL SPECIFICITY
PROTEIN PHOSPHATASE
13


(Homo sapiens)
PF00782
(DSPc)
5 ASN A  44
LEU A  55
VAL A 142
ILE A 174
LEU A  35
None
1.22A 4k39A-2gwoA:
undetectable
4k39A-2gwoA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8q RED FLUORESCENT
PROTEIN DRFP583


(Discosoma sp.)
PF01353
(GFP)
5 PHE A  56
GLN A 213
LEU A  46
VAL A  48
ILE A  29
None
CRQ  A  66 ( 3.9A)
None
None
None
1.23A 4k39A-2h8qA:
undetectable
4k39A-2h8qA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hv2 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis)
PF13527
(Acetyltransf_9)
PF13530
(SCP2_2)
5 PHE A  68
TYR A 295
LEU A 288
ILE A 285
LEU A 358
None
1.30A 4k39A-2hv2A:
undetectable
4k39A-2hv2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4


(Homo sapiens)
PF00102
(Y_phosphatase)
5 TYR A 709
GLN A 739
LEU A 698
VAL A 696
ILE A 705
None
1.14A 4k39A-2i75A:
undetectable
4k39A-2i75A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ny0 ENVELOPE
GLYCOPROTEIN GP120


(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 PHE A 391
ASN A 332
VAL A 292
ILE A 449
LEU A 452
None
1.38A 4k39A-2ny0A:
undetectable
4k39A-2ny0A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE


(Escherichia
coli)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N)
5 PHE A 277
ASN A 268
LEU A 262
ILE A 280
LEU A 178
None
1.36A 4k39A-2o1sA:
undetectable
4k39A-2o1sA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oc6 YDHG PROTEIN

(Bacillus
subtilis)
PF08818
(DUF1801)
5 TYR A 100
LEU A  62
VAL A  98
ILE A  92
LEU A 102
GOL  A 130 ( 3.8A)
None
None
None
None
1.26A 4k39A-2oc6A:
undetectable
4k39A-2oc6A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis)
no annotation 5 TYR A 332
TYR A  33
GLU A  87
LEU A 204
LEU A 303
None
None
FEO  A 701 (-2.9A)
None
None
1.40A 4k39A-2q9uA:
undetectable
4k39A-2q9uA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq4 CUG-BP- AND
ETR-3-LIKE FACTOR 1


(Homo sapiens)
PF00076
(RRM_1)
5 TYR A 449
GLU A 396
LEU A 476
VAL A 474
ILE A 459
None
1.03A 4k39A-2rq4A:
undetectable
4k39A-2rq4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vad RED FLUORESCENT
PROTEIN


(Discosoma sp.)
PF01353
(GFP)
5 PHE A  56
GLN A 213
LEU A  46
VAL A  48
ILE A  29
None
CRQ  A  66 ( 3.8A)
None
None
None
1.22A 4k39A-2vadA:
undetectable
4k39A-2vadA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgl GFP-LIKE FLUORESCENT
CHROMOPROTEIN
DSFP483


(Discosoma
striata)
PF01353
(GFP)
5 PHE A  56
ASN A 205
LEU A  46
VAL A  48
ILE A  29
None
0.68A 4k39A-3cglA:
undetectable
4k39A-3cglA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpi RAB GDP-DISSOCIATION
INHIBITOR


(Saccharomyces
cerevisiae)
PF00996
(GDI)
5 TYR G 234
PHE G 110
ASN G  81
SER G  50
LEU G  89
None
1.42A 4k39A-3cpiG:
undetectable
4k39A-3cpiG:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE


(Homo sapiens)
PF00288
(GHMP_kinases_N)
5 TYR A 131
SER A 114
VAL A 112
ILE A  65
LEU A  83
None
1.21A 4k39A-3d4jA:
undetectable
4k39A-3d4jA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE


(Phanerochaete
chrysosporium)
PF12708
(Pectate_lyase_3)
5 TYR A  94
PHE A 156
GLN A  23
VAL A  46
LEU A 108
None
1.39A 4k39A-3eqnA:
undetectable
4k39A-3eqnA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzq PUTATIVE HYDROLASE

(Clostridioides
difficile)
PF08282
(Hydrolase_3)
5 PHE A 221
LEU A  58
VAL A  40
ILE A  30
LEU A 267
None
1.42A 4k39A-3fzqA:
undetectable
4k39A-3fzqA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j70 ENVELOPE
GLYCOPROTEIN GP120


(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 PHE D 391
ASN D 332
VAL D 292
ILE D 449
LEU D 452
None
1.37A 4k39A-3j70D:
undetectable
4k39A-3j70D:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ja6 CHEMOTAXIS PROTEIN
CHEW


(Escherichia
coli)
PF01584
(CheW)
5 GLU A  17
SER A  15
LEU A 102
ILE A 104
LEU A 109
None
1.41A 4k39A-3ja6A:
undetectable
4k39A-3ja6A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN


(Homo sapiens)
PF00516
(GP120)
5 PHE A 391
ASN A 332
VAL A 292
ILE A 449
LEU A 452
None
1.44A 4k39A-3jwoA:
undetectable
4k39A-3jwoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN


(Saccharomyces
cerevisiae)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 PHE A 741
GLU A 677
LEU A 731
ILE A 696
LEU A 739
None
1.33A 4k39A-3k4xA:
undetectable
4k39A-3k4xA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsp DEST

(Pseudomonas
aeruginosa)
PF00440
(TetR_N)
5 PHE A  96
GLU A  66
SER A 105
LEU A 108
ILE A 173
OLA  A 221 ( 4.6A)
None
SO4  A 222 ( 4.4A)
None
None
1.41A 4k39A-3lspA:
undetectable
4k39A-3lspA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956


(Vibrio
parahaemolyticus)
no annotation 5 PHE A  72
GLU A   6
LEU A  57
ILE A  59
LEU A  68
None
1.27A 4k39A-3nlcA:
undetectable
4k39A-3nlcA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1x SERINE
ACETYLTRANSFERASE


(Entamoeba
histolytica)
PF00132
(Hexapep)
5 GLU A 153
LEU A 142
VAL A  89
ILE A  92
LEU A  65
None
1.41A 4k39A-3q1xA:
undetectable
4k39A-3q1xA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE


(Actinobacillus
pleuropneumoniae)
no annotation 5 GLU A 580
ASN A 577
VAL A 461
ILE A 433
LEU A 450
None
1.40A 4k39A-3q3hA:
2.5
4k39A-3q3hA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Sorangium
cellulosum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLU A  61
LEU A  36
VAL A  38
ILE A  12
LEU A 371
None
1.29A 4k39A-3s5sA:
3.9
4k39A-3s5sA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT


(uncultured
archaeon)
PF02240
(MCR_gamma)
5 PHE C  93
GLN C 226
ARG C  15
VAL C  11
LEU C 211
None
1.43A 4k39A-3sqgC:
undetectable
4k39A-3sqgC:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyg ENVELOPE
GLYCOPROTEIN GP160


(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 PHE A 180
ASN A 121
VAL A  95
ILE A  19
LEU A  22
None
NAG  A 200 (-1.9A)
None
None
None
1.32A 4k39A-3tygA:
undetectable
4k39A-3tygA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uau SURFACE-EXPOSED
LIPOPROTEIN


(Campylobacter
jejuni)
PF16668
(JLPA)
5 PHE A 221
TYR A 115
GLN A 123
ILE A 101
LEU A 226
None
1.41A 4k39A-3uauA:
undetectable
4k39A-3uauA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E


(Streptomyces
chartreusis)
PF01370
(Epimerase)
5 GLU A 133
GLN A 278
ASN A 233
VAL A 216
LEU A  23
None
1.30A 4k39A-3vpsA:
undetectable
4k39A-3vpsA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN


(Staphylococcus
aureus)
PF10672
(Methyltrans_SAM)
5 PHE A 256
GLU A 180
ASN A 181
ARG A 209
LEU A 208
None
1.42A 4k39A-3vseA:
undetectable
4k39A-3vseA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0q RESTRICTION
ENDONUCLEASE


(Mycobacterium
sp. JLS)
PF04471
(Mrr_cat)
5 PHE A 335
GLU A 451
ARG A 376
LEU A 377
VAL A 373
None
1.31A 4k39A-4f0qA:
undetectable
4k39A-4f0qA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora)
PF02171
(Piwi)
5 PHE A 392
TYR A 277
ASN A 329
LEU A 428
ILE A 274
None
1.32A 4k39A-4f1nA:
undetectable
4k39A-4f1nA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN


(Escherichia
coli;
Candida
albicans)
PF00225
(Kinesin)
PF13416
(SBP_bac_8)
5 PHE A 565
ASN A 435
SER A 430
LEU A 431
ILE A 467
None
1.33A 4k39A-4h1gA:
undetectable
4k39A-4h1gA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5


(Saccharomyces
cerevisiae)
PF09084
(NMT1)
5 GLU A 325
GLN A 165
ARG A 186
ILE A 160
LEU A  84
None
1.34A 4k39A-4h65A:
undetectable
4k39A-4h65A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfn ALLYL ALCOHOL
DEHYDROGENASE


(Nicotiana
tabacum)
PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2)
5 TYR A 294
TYR A 130
GLU A 311
VAL A 298
ILE A 299
None
1.24A 4k39A-4hfnA:
undetectable
4k39A-4hfnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Thermobifida
fusca)
PF02011
(Glyco_hydro_48)
5 TYR A 265
GLN A  91
ASN A 141
ARG A 316
LEU A 263
None
1.41A 4k39A-4jjjA:
undetectable
4k39A-4jjjA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz5 GP26

(Listeria phage
P40)
PF01183
(Glyco_hydro_25)
5 TYR A  16
GLU A  39
VAL A  14
ILE A 182
LEU A   5
None
1.44A 4k39A-4jz5A:
3.7
4k39A-4jz5A:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME


(Clostridium
perfringens)
PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12)
7 TYR A  21
PHE A  23
GLN A  98
LEU A 163
VAL A 165
ILE A 192
LEU A 195
SAM  A 504 (-4.6A)
SAM  A 504 (-4.2A)
SAM  A 504 (-4.4A)
SAM  A 504 (-3.8A)
SAM  A 504 (-4.7A)
SAM  A 504 (-4.0A)
SAM  A 504 (-4.1A)
1.06A 4k39A-4k37A:
59.6
4k39A-4k37A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME


(Clostridium
perfringens)
PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12)
11 TYR A  21
PHE A  23
TYR A  24
GLU A  67
ASN A 100
SER A 122
ARG A 134
LEU A 163
VAL A 165
ILE A 192
LEU A 195
SAM  A 504 (-4.6A)
SAM  A 504 (-4.2A)
SAM  A 504 ( 3.4A)
SAM  A 504 (-4.1A)
SF4  A 503 ( 4.2A)
SAM  A 504 (-2.5A)
SAM  A 504 ( 3.5A)
SAM  A 504 (-3.8A)
SAM  A 504 (-4.7A)
SAM  A 504 (-4.0A)
SAM  A 504 (-4.1A)
0.30A 4k39A-4k37A:
59.6
4k39A-4k37A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11


(synthetic
construct)
PF01353
(GFP)
5 PHE C  56
GLN C 253
LEU C  46
VAL C  48
ILE C  29
None
CH6  C  66 ( 4.7A)
None
None
None
1.16A 4k39A-4kf5C:
undetectable
4k39A-4kf5C:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN


(Pseudomonas
protegens)
PF13458
(Peripla_BP_6)
5 PHE A  32
GLN A 101
SER A  55
VAL A  59
LEU A  65
None
1.27A 4k39A-4maaA:
undetectable
4k39A-4maaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1
SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101


(Arabidopsis
thaliana;
Arabidopsis
thaliana)
PF01764
(Lipase_3)
PF01764
(Lipase_3)
5 PHE A 295
TYR A 296
GLN A 356
LEU B   7
VAL A 244
None
1.45A 4k39A-4nfuA:
undetectable
4k39A-4nfuA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Thermotoga
maritima)
PF00496
(SBP_bac_5)
5 GLU A  77
LEU A 103
VAL A 108
ILE A 162
LEU A 160
None
1.39A 4k39A-4pfwA:
undetectable
4k39A-4pfwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29


(Fusarium
graminearum)
PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C)
5 ASN A 433
LEU A 471
VAL A 429
ILE A 473
LEU A 450
None
None
TRS  A 618 (-3.9A)
None
None
1.33A 4k39A-4pspA:
2.9
4k39A-4pspA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rx4 HIV-1 CLADE A
Q842.D12 GP120


(Human
immunodeficiency
virus 1)
no annotation 5 PHE G 391
ASN G 332
VAL G 292
ILE G 449
LEU G 452
None
NAG  G 502 (-4.3A)
None
None
None
1.42A 4k39A-4rx4G:
undetectable
4k39A-4rx4G:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v19 MITORIBOSOMAL
PROTEIN BL31M,
MRPL55


(Sus scrofa)
PF09776
(Mitoc_L55)
5 ARG 4  73
LEU 4  57
VAL 4  55
ILE 4  67
LEU 4  52
None
1.24A 4k39A-4v194:
undetectable
4k39A-4v194:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v39 SIALYLTRANSFERASE

(Pasteurella
dagmatis)
PF11477
(PM0188)
5 TYR A 170
GLN A 165
SER A 164
VAL A 168
LEU A  81
None
1.40A 4k39A-4v39A:
2.3
4k39A-4v39A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvs DONOR 45 01DG5 COREE
GP120


(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 PHE G 391
ASN G 332
VAL G 292
ILE G 449
LEU G 452
None
NAG  G 602 (-4.0A)
None
None
None
1.42A 4k39A-4xvsG:
undetectable
4k39A-4xvsG:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi ENVELOPE
GLYCOPROTEIN GP160


(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 PHE G 391
ASN G 332
VAL G 292
ILE G 449
LEU G 452
None
NAG  G 505 (-1.9A)
None
None
None
1.24A 4k39A-4ydiG:
undetectable
4k39A-4ydiG:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye4 HT593.1 GP120

(Human
immunodeficiency
virus)
PF00516
(GP120)
5 PHE G 391
ASN G 332
VAL G 292
ILE G 449
LEU G 452
None
NAG  G 505 (-4.4A)
None
None
None
1.36A 4k39A-4ye4G:
undetectable
4k39A-4ye4G:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7x HIV-1 YU2 GP120

(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 PHE A 391
ASN A 332
VAL A 292
ILE A 449
LEU A 452
None
1.42A 4k39A-5a7xA:
undetectable
4k39A-5a7xA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3i STAPHYLOCOCCAL
SUPERANTIGEN-LIKE
PROTEIN 3


(Staphylococcus
aureus)
PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB)
5 TYR B 278
GLU B 273
LEU B 267
VAL B 323
ILE B 286
None
1.28A 4k39A-5d3iB:
undetectable
4k39A-5d3iB:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3v ADENYLOSUCCINATE
LYASE


(Salmonella
enterica)
PF00206
(Lyase_1)
PF08328
(ASL_C)
5 ASN A 313
SER A 317
LEU A 321
ILE A 261
LEU A 144
None
1.17A 4k39A-5e3vA:
undetectable
4k39A-5e3vA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4l ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C


(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 PHE A 391
ASN A 332
VAL A 292
ILE A 449
LEU A 452
None
1.33A 4k39A-5f4lA:
undetectable
4k39A-5f4lA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA,
TFA2
TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA,
TFG2


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF02186
(TFIIE_beta)
PF02270
(TFIIF_beta)
5 PHE V 307
SER S 152
ARG V 352
VAL V 336
LEU V 303
None
1.37A 4k39A-5fmfV:
undetectable
4k39A-5fmfV:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4d SUPERANTIGEN-LIKE
PROTEIN


(Staphylococcus
aureus)
PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB)
5 TYR A 308
GLU A 303
LEU A 297
VAL A 353
ILE A 316
None
1.34A 4k39A-5i4dA:
undetectable
4k39A-5i4dA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT


(Pyrococcus
abyssi)
PF00149
(Metallophos)
5 GLN A 557
SER A 577
LEU A 357
VAL A 599
LEU A 380
None
1.43A 4k39A-5iheA:
undetectable
4k39A-5iheA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1g 1-CYS PEROXIREDOXIN

(Vibrio
vulnificus)
PF08534
(Redoxin)
5 GLU A 151
ASN A 149
LEU A  53
ILE A  94
LEU A  70
None
1.38A 4k39A-5k1gA:
undetectable
4k39A-5k1gA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE


(Cryptococcus
neoformans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N)
5 PHE A 285
TYR A 306
ASN A 107
LEU A 346
ILE A 342
None
1.37A 4k39A-5k8fA:
undetectable
4k39A-5k8fA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3l EXTRACELLULAR
GLOBIN-2


(Lumbricus
terrestris)
PF00042
(Globin)
5 GLU B   8
LEU B 114
VAL B 117
ILE B 113
LEU B  69
None
1.37A 4k39A-5m3lB:
undetectable
4k39A-5m3lB:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus)
no annotation 5 TYR A 697
TYR A 550
ASN A 785
VAL A 782
ILE A 778
None
1.43A 4k39A-5n2gA:
undetectable
4k39A-5n2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2


(Homo sapiens)
PF04056
(Ssl1)
5 PHE E  91
TYR E  95
ASN E 123
LEU E 120
LEU E 168
None
1.35A 4k39A-5of4E:
undetectable
4k39A-5of4E:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Campylobacter
jejuni)
PF00275
(EPSP_synthase)
5 PHE A 157
ASN A  23
LEU A 193
ILE A 169
LEU A 181
None
1.34A 4k39A-5ujsA:
undetectable
4k39A-5ujsA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 PHE G 391
ASN G 332
VAL G 292
ILE G 449
LEU G 452
None
NAG  G 728 (-1.8A)
None
None
None
1.29A 4k39A-5um8G:
undetectable
4k39A-5um8G:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1s RADICAL SAM

(Streptococcus
suis)
PF04055
(Radical_SAM)
PF13394
(Fer4_14)
5 PHE A 125
GLU A 161
ASN A 187
SER A 210
VAL A 249
SAM  A 604 (-4.8A)
SAM  A 604 (-4.4A)
SF4  A 601 (-4.4A)
SAM  A 604 (-2.4A)
SAM  A 604 (-4.2A)
0.71A 4k39A-5v1sA:
23.3
4k39A-5v1sA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2


(Mus musculus)
PF04055
(Radical_SAM)
PF13353
(Fer4_12)
5 GLU A 127
ASN A 158
SER A 180
VAL A 224
LEU A 252
SAH  A 402 (-4.3A)
SF4  A 401 ( 4.3A)
SAH  A 402 (-2.4A)
SAH  A 402 (-4.3A)
SAH  A 402 (-4.5A)
0.51A 4k39A-5vslA:
19.2
4k39A-5vslA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgg RADICAL SAM DOMAIN
PROTEIN


(Ruminiclostridium
thermocellum)
PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12)
5 TYR A 110
GLU A 155
ASN A 188
SER A 210
ARG A 222
SAM  A 504 (-4.8A)
SAM  A 504 (-3.7A)
SF4  A 502 ( 4.3A)
SAM  A 504 (-2.5A)
SF4  A 502 ( 3.6A)
0.21A 4k39A-5wggA:
31.1
4k39A-5wggA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
RNA POLYMERASE II
SUBUNIT B12.5


(Komagataella
phaffii;
Komagataella
phaffii;
Komagataella
phaffii)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF13656
(RNA_pol_L_2)
5 TYR K  53
GLU A 545
SER C  27
LEU K  45
ILE K  94
None
1.37A 4k39A-5xogK:
undetectable
4k39A-5xogK:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyu 30S RIBOSOMAL
PROTEIN S7


(Mycolicibacterium
smegmatis)
PF00177
(Ribosomal_S7)
5 ASN G 106
SER G 108
LEU G 120
ILE G  42
LEU G  38
C  A 922 ( 4.9A)
None
None
U  A1221 ( 3.6A)
G  A1222 ( 4.1A)
1.26A 4k39A-5xyuG:
undetectable
4k39A-5xyuG:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9d ACYL-COENZYME A
OXIDASE 1


(Yarrowia
lipolytica)
no annotation 5 PHE A 627
GLU A  16
GLN A 619
VAL A  24
LEU A  31
None
1.40A 4k39A-5y9dA:
undetectable
4k39A-5y9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris)
no annotation 5 GLU A  25
SER A 463
LEU A 130
ILE A 394
LEU A 355
None
1.44A 4k39A-5z0uA:
3.5
4k39A-5z0uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0n ENVELOPE
GLYCOPROTEIN GP140


(Human
immunodeficiency
virus 1)
no annotation 5 PHE G 391
ASN G 332
VAL G 292
ILE G 449
LEU G 452
None
NAG  G1331 ( 2.0A)
None
None
None
1.26A 4k39A-6b0nG:
undetectable
4k39A-6b0nG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1


(Mus musculus)
no annotation 5 TYR A2398
PHE A2372
ASN A2385
LEU A2390
LEU A2399
None
1.39A 4k39A-6b3rA:
undetectable
4k39A-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnf PHOSPHOETHANOLAMINE
TRANSFERASE


(Moraxella sp.
HMSC061H09)
no annotation 5 PHE A 560
GLN A 373
LEU A 369
ILE A 343
LEU A 556
None
1.26A 4k39A-6bnfA:
undetectable
4k39A-6bnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwy PROTECTION OF
TELOMERES PROTEIN 1,
DNA DC->
DU-EDITING ENZYME
APOBEC-3G FUSION


(Schizosaccharomyces
pombe;
Homo sapiens)
no annotation 5 TYR A  40
GLN A  48
SER A  52
ARG A  51
LEU A 185
None
1.41A 4k39A-6bwyA:
undetectable
4k39A-6bwyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dcq ENVELOPE
GLYCOPROTEIN GP160


(Human
immunodeficiency
virus 1)
no annotation 5 PHE A 391
ASN A 332
VAL A 292
ILE A 449
LEU A 452
None
NAG  A 603 ( 2.1A)
None
None
None
1.36A 4k39A-6dcqA:
undetectable
4k39A-6dcqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN


(Azotobacter
vinelandii)
no annotation 5 PHE A 164
ARG A 271
LEU A 268
ILE A 264
LEU A 183
None
1.43A 4k39A-6feaA:
undetectable
4k39A-6feaA:
undetectable