SIMILAR PATTERNS OF AMINO ACIDS FOR 4K38_B_SAMB504_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak0 P1 NUCLEASE

(Penicillium
citrinum) 		PF02265
(S1-P1_nuclease) 		5 TYR A 237
PHE A 141
GLN A 123
VAL A 241
ILE A 245
 None
 1.17A 4k38B-1ak0A:
0.0		 4k38B-1ak0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dql IGM MEZ
IMMUNOGLOBULIN

(Homo sapiens) 		PF07686
(V-set) 		5 PHE L  83
GLN L  37
LEU L  73
VAL L  19
ILE L  75
 None
 1.21A 4k38B-1dqlL:
undetectable		 4k38B-1dqlL:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exf EXFOLIATVE TOXIN A

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		5 PHE A  66
GLU A  78
GLN A  26
ILE A 118
LEU A  46
 None
 1.40A 4k38B-1exfA:
undetectable		 4k38B-1exfA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		5 PHE A 167
GLN A  99
LEU A  20
ILE A  18
LEU A  31
 None
 1.35A 4k38B-1g0vA:
undetectable		 4k38B-1g0vA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE

(Acinetobacter
sp.) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 TYR A 271
GLU A 233
GLN A 258
LEU A 226
ILE A 222
 None
 1.30A 4k38B-1krhA:
0.8		 4k38B-1krhA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 PHE A  97
TYR A 126
GLN A 125
GLU A 119
ARG A  47
 None
 1.45A 4k38B-1l8kA:
0.0		 4k38B-1l8kA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		5 GLU A 707
ARG A 684
LEU A 685
ILE A 748
LEU A 721
 None
None
None
None
A  T  35 ( 4.6A)
 1.26A 4k38B-1qu2A:
0.0		 4k38B-1qu2A:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 TYR A 466
LEU A 462
VAL A 464
ILE A 412
LEU A 376
 None
None
None
None
COA  A2600 (-4.9A)
 1.37A 4k38B-2ahwA:
1.2		 4k38B-2ahwA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1i PEPTIDOGLYCAN GLCNAC
DEACETYLASE

(Streptococcus
pneumoniae) 		PF01522
(Polysacc_deac_1) 		5 TYR A 439
PHE A 441
VAL A 408
ILE A 404
LEU A 272
 None
 1.37A 4k38B-2c1iA:
0.9		 4k38B-2c1iA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crp REGULATOR OF
G-PROTEIN SIGNALING
5

(Homo sapiens) 		PF00615
(RGS) 		5 CYH A  61
GLU A  83
GLN A  79
ILE A  67
LEU A 112
 None
 1.16A 4k38B-2crpA:
undetectable		 4k38B-2crpA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		5 PHE A 445
TYR A 446
GLN A  68
LEU A 313
LEU A 208
 None
 1.47A 4k38B-2gfiA:
undetectable		 4k38B-2gfiA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		5 GLU A  97
GLN A  92
ARG A 122
VAL A 127
LEU A 199
 None
 1.44A 4k38B-2q6zA:
3.7		 4k38B-2q6zA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 5 TYR A 332
TYR A  33
GLU A  87
LEU A 204
LEU A 303
 None
None
FEO  A 701 (-2.9A)
None
None
 1.31A 4k38B-2q9uA:
undetectable		 4k38B-2q9uA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vad RED FLUORESCENT
PROTEIN

(Discosoma sp.) 		PF01353
(GFP) 		5 PHE A  56
GLN A 213
LEU A  46
VAL A  48
ILE A  29
 None
CRQ  A  66 ( 3.8A)
None
None
None
 1.14A 4k38B-2vadA:
undetectable		 4k38B-2vadA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vla RESTRICTION
ENDONUCLEASE R.BPUJI

(Bacillus
pumilus) 		PF11564
(BpuJI_N) 		5 TYR A 140
GLN A 213
VAL A 164
ILE A 160
LEU A 145
 None
 1.35A 4k38B-2vlaA:
undetectable		 4k38B-2vlaA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cii NATURAL KILLER CELLS
ANTIGEN CD94

(Homo sapiens) 		PF00059
(Lectin_C) 		5 PHE G 114
GLU G 104
LEU G 119
ILE G 153
LEU G 162
 None
 1.37A 4k38B-3ciiG:
undetectable		 4k38B-3ciiG:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4s PUTATIVE
UNCHARACTERIZED
PROTEIN

(Wolbachia
endosymbiont of
Drosophila
melanogaster) 		PF13462
(Thioredoxin_4) 		5 TYR A  98
GLU A 102
VAL A 111
ILE A 132
LEU A  94
 None
 1.34A 4k38B-3f4sA:
undetectable		 4k38B-3f4sA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzq PUTATIVE HYDROLASE

(Clostridioides
difficile) 		PF08282
(Hydrolase_3) 		5 PHE A 221
LEU A  58
VAL A  40
ILE A  30
LEU A 267
 None
 1.47A 4k38B-3fzqA:
undetectable		 4k38B-3fzqA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gn6 CT0912, ORFAN
PROTEIN WITH A
FERREDOXIN-LIKE
DOMAIN REPEAT

(Chlorobaculum
tepidum) 		no annotation 5 GLU A 191
LEU A 258
VAL A 168
ILE A 257
LEU A 221
 None
 1.44A 4k38B-3gn6A:
undetectable		 4k38B-3gn6A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt7 SENSOR PROTEIN

(Syntrophus
aciditrophicus) 		PF00072
(Response_reg) 		5 TYR A  71
CYH A 106
LEU A  91
VAL A  63
LEU A  73
 None
 1.03A 4k38B-3gt7A:
undetectable		 4k38B-3gt7A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jys SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 PHE A 410
GLN A  89
GLU A  95
ARG A 470
LEU A 229
 None
 1.40A 4k38B-3jysA:
undetectable		 4k38B-3jysA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 PHE A 741
GLU A 677
LEU A 731
ILE A 696
LEU A 739
 None
 1.47A 4k38B-3k4xA:
undetectable		 4k38B-3k4xA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102
FLUORESCENT TIMER
PRECURSOR BLUE102

(Discosoma sp.;
Discosoma sp.) 		PF01353
(GFP)
PF01353
(GFP) 		5 PHE A  56
GLN B 213
LEU A  46
VAL A  48
ILE A  29
 None
LEN  A  66 (-4.5A)
None
None
None
 1.20A 4k38B-3lf4A:
undetectable		 4k38B-3lf4A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 5 PHE A  72
GLU A   6
LEU A  57
ILE A  59
LEU A  68
 None
 1.35A 4k38B-3nlcA:
undetectable		 4k38B-3nlcA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13468
(Glyoxalase_3) 		5 PHE A  40
TYR A 268
GLU A 271
ILE A  28
LEU A  72
 None
 1.38A 4k38B-3p8aA:
undetectable		 4k38B-3p8aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxy NIF3 PROTEIN

(Sphaerobacter
thermophilus) 		no annotation 5 TYR A 258
GLU A 173
ARG A 271
VAL A 269
LEU A   9
 None
 1.44A 4k38B-3rxyA:
undetectable		 4k38B-3rxyA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00619
(CARD)
PF00653
(BIR)
PF13920
(zf-C3HC4_3) 		5 CYH A 306
PHE A 295
GLU A 334
ARG A 614
LEU A 313
 ZN  A1002 (-2.2A)
None
None
None
None
 1.42A 4k38B-3t6pA:
undetectable		 4k38B-3t6pA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		5 GLU A 133
GLN A  85
LEU A 118
ILE A 122
LEU A 147
 None
 1.46A 4k38B-3wvnA:
undetectable		 4k38B-3wvnA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k DNA DAMAGE-BINDING
PROTEIN 2

(Danio rerio) 		PF00400
(WD40) 		5 GLN D 127
LEU D 387
VAL D 389
ILE D 408
LEU D 420
 None
 1.50A 4k38B-4a0kD:
undetectable		 4k38B-4a0kD:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 PHE P 665
ARG P 626
LEU P 617
VAL P 641
ILE P 642
 None
 1.49A 4k38B-4crnP:
undetectable		 4k38B-4crnP:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF06431
(Polyoma_lg_T_C) 		5 CYH A 337
TYR A 292
GLN A 296
VAL A 268
LEU A 272
 None
 1.45A 4k38B-4e2iA:
undetectable		 4k38B-4e2iA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5

(Saccharomyces
cerevisiae) 		PF09084
(NMT1) 		5 GLU A 325
GLN A 165
ARG A 186
ILE A 160
LEU A  84
 None
 1.31A 4k38B-4h65A:
undetectable		 4k38B-4h65A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		5 CYH A 253
GLN A 461
VAL A 433
ILE A 257
LEU A 339
 None
 1.50A 4k38B-4ig9A:
undetectable		 4k38B-4ig9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz5 GP26

(Listeria phage
P40) 		PF01183
(Glyco_hydro_25) 		5 TYR A  16
GLU A  39
VAL A  14
ILE A 182
LEU A   5
 None
 1.35A 4k38B-4jz5A:
2.7		 4k38B-4jz5A:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME

(Clostridium
perfringens) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		10 TYR A  21
CYH A  22
PHE A  23
GLU A  67
GLN A  98
ARG A 134
LEU A 163
VAL A 165
ILE A 192
LEU A 195
 SAM  A 504 (-4.6A)
SF4  A 503 ( 2.2A)
SAM  A 504 (-4.2A)
SAM  A 504 (-4.1A)
SAM  A 504 (-4.4A)
SAM  A 504 ( 3.5A)
SAM  A 504 (-3.8A)
SAM  A 504 (-4.7A)
SAM  A 504 (-4.0A)
SAM  A 504 (-4.1A)
 0.86A 4k38B-4k37A:
58.5		 4k38B-4k37A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME

(Clostridium
perfringens) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		10 TYR A  21
CYH A  22
PHE A  23
TYR A  24
GLU A  67
ARG A 134
LEU A 163
VAL A 165
ILE A 192
LEU A 195
 SAM  A 504 (-4.6A)
SF4  A 503 ( 2.2A)
SAM  A 504 (-4.2A)
SAM  A 504 ( 3.4A)
SAM  A 504 (-4.1A)
SAM  A 504 ( 3.5A)
SAM  A 504 (-3.8A)
SAM  A 504 (-4.7A)
SAM  A 504 (-4.0A)
SAM  A 504 (-4.1A)
 0.36A 4k38B-4k37A:
58.5		 4k38B-4k37A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME

(Clostridium
perfringens) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		8 TYR A  21
GLN A  64
GLU A  67
ARG A 134
LEU A 163
VAL A 165
ILE A 192
LEU A 195
 SAM  A 504 (-4.6A)
None
SAM  A 504 (-4.1A)
SAM  A 504 ( 3.5A)
SAM  A 504 (-3.8A)
SAM  A 504 (-4.7A)
SAM  A 504 (-4.0A)
SAM  A 504 (-4.1A)
 0.87A 4k38B-4k37A:
58.5		 4k38B-4k37A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME

(Clostridium
perfringens) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		7 TYR A  21
GLN A  98
GLU A  67
ARG A 134
VAL A 165
ILE A 192
LEU A 195
 SAM  A 504 (-4.6A)
SAM  A 504 (-4.4A)
SAM  A 504 (-4.1A)
SAM  A 504 ( 3.5A)
SAM  A 504 (-4.7A)
SAM  A 504 (-4.0A)
SAM  A 504 (-4.1A)
 1.30A 4k38B-4k37A:
58.5		 4k38B-4k37A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11

(synthetic
construct) 		PF01353
(GFP) 		5 PHE C  56
GLN C 253
LEU C  46
VAL C  48
ILE C  29
 None
CH6  C  66 ( 4.7A)
None
None
None
 1.09A 4k38B-4kf5C:
undetectable		 4k38B-4kf5C:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v19 MITORIBOSOMAL
PROTEIN BL31M,
MRPL55

(Sus scrofa) 		PF09776
(Mitoc_L55) 		5 ARG 4  73
LEU 4  57
VAL 4  55
ILE 4  67
LEU 4  52
 None
 1.30A 4k38B-4v194:
undetectable		 4k38B-4v194:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xea PEPTIDASE M16 DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 GLU A 265
ARG A 407
LEU A 284
ILE A 283
LEU A 400
 None
 1.47A 4k38B-4xeaA:
undetectable		 4k38B-4xeaA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		5 CYH A 253
GLN A 461
VAL A 433
ILE A 257
LEU A 339
 None
 1.41A 4k38B-4zzhA:
undetectable		 4k38B-4zzhA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gq0 EPITHIOSPECIFIER
PROTEIN

(Arabidopsis
thaliana) 		no annotation 5 TYR B 306
GLU B  41
ARG B  80
ILE B  28
LEU B 318
 None
 1.49A 4k38B-5gq0B:
undetectable		 4k38B-5gq0B:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kem BDBV91 VARIABLE FAB
DOMAIN LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 PHE C  83
GLN C  37
LEU C  73
VAL C  19
ILE C  75
 None
 1.23A 4k38B-5kemC:
undetectable		 4k38B-5kemC:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lk4 MSCARLET

(Discosoma sp.) 		PF01353
(GFP) 		5 PHE A  57
GLN A 214
LEU A  47
VAL A  49
ILE A  30
 None
NRQ  A  67 ( 4.5A)
None
None
None
 1.24A 4k38B-5lk4A:
undetectable		 4k38B-5lk4A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3l EXTRACELLULAR
GLOBIN-2

(Lumbricus
terrestris) 		PF00042
(Globin) 		5 GLU B   8
LEU B 114
VAL B 117
ILE B 113
LEU B  69
 None
 1.45A 4k38B-5m3lB:
undetectable		 4k38B-5m3lB:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 5 CYH A 717
PHE A 716
GLU A 470
LEU A 730
ILE A 701
 None
 1.50A 4k38B-5n94A:
undetectable		 4k38B-5n94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE

(Trypanosoma
brucei) 		no annotation 5 PHE A 762
LEU A 728
VAL A 723
ILE A 724
LEU A 717
 None
 1.43A 4k38B-5nfhA:
undetectable		 4k38B-5nfhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxx RNA POLYMERASE SIGMA
FACTOR
ANTI-SIGMA FACTOR
NEPR

(Bartonella
quintana;
Bartonella
quintana) 		no annotation
no annotation 		5 PHE A 106
GLU A  89
LEU A  26
ILE A 122
LEU B  30
 None
 1.47A 4k38B-5uxxA:
undetectable		 4k38B-5uxxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8j CYCLIC GMP-AMP
SYNTHASE

(Homo sapiens) 		PF03281
(Mab-21) 		5 CYH A 474
PHE A 471
LEU A 495
ILE A 496
LEU A 504
 None
 1.26A 4k38B-5v8jA:
undetectable		 4k38B-5v8jA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		5 CYH A  91
GLU A 127
ARG A 194
VAL A 224
LEU A 252
 SF4  A 401 ( 2.4A)
SAH  A 402 (-4.3A)
SAH  A 402 ( 3.4A)
SAH  A 402 (-4.3A)
SAH  A 402 (-4.5A)
 0.83A 4k38B-5vslA:
19.8		 4k38B-5vslA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3l C5 ANTIBODY VARIABLE
LIGHT DOMAIN

(Mus musculus) 		PF07686
(V-set) 		5 PHE G  83
GLN G  37
LEU G  73
VAL G  19
ILE G  75
 None
 1.05A 4k38B-5w3lG:
undetectable		 4k38B-5w3lG:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvi GLUTAMATE
DEHYDROGENASE

(Aspergillus
niger) 		no annotation 5 TYR A 169
CYH A 141
GLN A  69
VAL A 179
LEU A 165
 None
 1.47A 4k38B-5xviA:
undetectable		 4k38B-5xviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzb CYCLIC GMP-AMP
SYNTHASE

(Mus musculus) 		PF03281
(Mab-21) 		5 CYH A 459
PHE A 456
LEU A 480
ILE A 481
LEU A 489
 None
 1.28A 4k38B-5xzbA:
undetectable		 4k38B-5xzbA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9d ACYL-COENZYME A
OXIDASE 1

(Yarrowia
lipolytica) 		no annotation 5 PHE A 627
GLU A  16
GLN A 619
VAL A  24
LEU A  31
 None
 1.39A 4k38B-5y9dA:
undetectable		 4k38B-5y9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7p SDED

(Legionella
pneumophila) 		no annotation 5 GLU A 242
LEU A 193
VAL A 202
ILE A 213
LEU A 217
 None
 1.33A 4k38B-6b7pA:
undetectable		 4k38B-6b7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnf PHOSPHOETHANOLAMINE
TRANSFERASE

(Moraxella sp.
HMSC061H09) 		no annotation 5 PHE A 560
GLN A 373
LEU A 369
ILE A 343
LEU A 556
 None
 1.37A 4k38B-6bnfA:
undetectable		 4k38B-6bnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 ANTIBODY FAB LIGHT
CHAIN

(Mus musculus) 		no annotation 5 GLN B  40
GLU B  90
LEU B  76
VAL B  19
ILE B  78
 None
 1.37A 4k38B-6c08B:
undetectable		 4k38B-6c08B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 5 PHE A 190
LEU A 155
VAL A 158
ILE A 156
LEU A 194
 None
HEM  A 401 ( 4.8A)
None
None
None
 1.37A 4k38B-6fshA:
undetectable		 4k38B-6fshA:
undetectable