SIMILAR PATTERNS OF AMINO ACIDS FOR 4JX1_F_CAMF502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvy PROTEIN (CYTOCHROME
P450 BM-3)

(Bacillus
megaterium) 		PF00258
(Flavodoxin_1) 		4 TYR F 564
THR F 588
VAL F 559
ILE F 531
 None
 1.28A 4jx1F-1bvyF:
0.0		 4jx1F-1bvyF:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geg ACETOIN REDUCTASE

(Klebsiella
pneumoniae) 		PF00106
(adh_short) 		4 TYR A 180
THR A   8
VAL A 114
ILE A 135
 None
 1.33A 4jx1F-1gegA:
0.0		 4jx1F-1gegA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqr VP4

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 TYR A 152
THR A 120
VAL A  91
ILE A 128
 None
 1.49A 4jx1F-1kqrA:
undetectable		 4jx1F-1kqrA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 TYR A 246
THR A 185
VAL A 169
ILE A 160
 None
 1.32A 4jx1F-1lrwA:
0.0		 4jx1F-1lrwA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 TYR A 112
THR A 163
VAL A 133
ILE A 592
 None
 1.38A 4jx1F-1pemA:
0.0		 4jx1F-1pemA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7g NAD-DEPENDENT
DEACETYLASE 2

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		4 TYR A 204
THR A 221
VAL A 189
ILE A 226
 None
 1.34A 4jx1F-1s7gA:
0.0		 4jx1F-1s7gA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 TYR A 402
THR A 327
VAL A 159
ILE A 615
 None
 1.39A 4jx1F-1sb3A:
0.0		 4jx1F-1sb3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 TYR D  83
THR D 164
VAL D 118
ILE D  92
 None
 1.00A 4jx1F-1sxjD:
0.0		 4jx1F-1sxjD:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		4 TYR A 154
THR A 243
VAL A 115
ILE A 214
 None
 1.49A 4jx1F-1us4A:
0.0		 4jx1F-1us4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxz CELLULASE B

(Cellvibrio
mixtus) 		PF03422
(CBM_6) 		4 TYR A  59
THR A  83
VAL A 102
ILE A 113
 None
 1.45A 4jx1F-1uxzA:
undetectable		 4jx1F-1uxzA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl1 6-PHOSPHOGLUCONOLACT
ONASE

(Thermotoga
maritima) 		PF01182
(Glucosamine_iso) 		4 TYR A  49
THR A  44
VAL A  14
ILE A 130
 None
 0.95A 4jx1F-1vl1A:
undetectable		 4jx1F-1vl1A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 TYR A 246
THR A 185
VAL A 169
ILE A 160
 None
 1.34A 4jx1F-1w6sA:
undetectable		 4jx1F-1w6sA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA

(Bacillus
subtilis) 		PF00496
(SBP_bac_5) 		4 TYR A 107
THR A  57
VAL A  84
ILE A 158
 None
 1.26A 4jx1F-1xocA:
undetectable		 4jx1F-1xocA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czn CHITINASE

(Pyrococcus
furiosus) 		PF00553
(CBM_2) 		4 TYR A 280
THR A 303
VAL A 319
ILE A 337
 None
 1.17A 4jx1F-2cznA:
undetectable		 4jx1F-2cznA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 TYR A 195
THR A 172
VAL A 432
ILE A 436
 None
 1.30A 4jx1F-2dkdA:
undetectable		 4jx1F-2dkdA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl3 R.HINP1I RESTRICTION
ENDONUCLEASE

(Haemophilus
influenzae) 		PF11463
(R-HINP1I) 		4 TYR A 200
THR A 242
VAL A 178
ILE A 247
 None
 1.46A 4jx1F-2fl3A:
undetectable		 4jx1F-2fl3A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		4 TYR A 406
THR A 433
VAL A 501
ILE A 428
 None
 1.48A 4jx1F-2i3oA:
undetectable		 4jx1F-2i3oA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE

(Bacillus sp.
snu-7) 		no annotation 4 TYR A 107
THR A  59
VAL A  77
ILE A 102
 None
 1.33A 4jx1F-2invA:
undetectable		 4jx1F-2invA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oej 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Geobacillus
kaustophilus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 TYR A  79
THR A   7
VAL A  51
ILE A  23
 None
 1.27A 4jx1F-2oejA:
undetectable		 4jx1F-2oejA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojh UNCHARACTERIZED
PROTEIN
ATU1656/AGR_C_3050

(Agrobacterium
fabrum) 		PF07676
(PD40) 		4 TYR A  53
THR A 116
VAL A  76
ILE A  90
 None
 1.30A 4jx1F-2ojhA:
undetectable		 4jx1F-2ojhA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3j VP4

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 TYR A 152
THR A 120
VAL A  91
ILE A 128
 None
 1.44A 4jx1F-2p3jA:
undetectable		 4jx1F-2p3jA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2
SEPTIN-6

(Homo sapiens;
Homo sapiens) 		PF00735
(Septin)
PF00735
(Septin) 		4 TYR A 258
THR A 186
VAL A 240
ILE B 189
 GDP  A 362 (-4.7A)
None
GDP  A 362 (-2.5A)
None
 1.06A 4jx1F-2qagA:
undetectable		 4jx1F-2qagA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x12 FIMBRIAE-ASSOCIATED
PROTEIN FAP1

(Streptococcus
parasanguinis) 		no annotation 4 TYR A 286
THR A 384
VAL A 346
ILE A 419
 None
 1.36A 4jx1F-2x12A:
undetectable		 4jx1F-2x12A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E1 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		4 TYR A 137
THR A 155
VAL A 144
ILE A 282
 None
 1.39A 4jx1F-2xfbA:
undetectable		 4jx1F-2xfbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygt DELTA TOXIN

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		4 TYR A 157
THR A 178
VAL A 184
ILE A 219
 None
 1.45A 4jx1F-2ygtA:
undetectable		 4jx1F-2ygtA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 TYR A  71
THR A   7
VAL A  20
ILE A  90
 None
 1.00A 4jx1F-3dcpA:
undetectable		 4jx1F-3dcpA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 TYR H 228
THR H 139
VAL H 200
ILE H 160
 None
 1.19A 4jx1F-3f6uH:
undetectable		 4jx1F-3f6uH:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9q FERRICHROME-BINDING
PROTEIN

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		4 TYR A 217
THR A 225
VAL A 204
ILE A 192
 None
 1.45A 4jx1F-3g9qA:
undetectable		 4jx1F-3g9qA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4f 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Bacillus
thuringiensis) 		PF13561
(adh_short_C2) 		4 TYR A 175
THR A  44
VAL A 153
ILE A 173
 None
 1.42A 4jx1F-3i4fA:
undetectable		 4jx1F-3i4fA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxe TOXIN PROTEIN PARE-1

(Caulobacter
vibrioides) 		PF05016
(ParE_toxin) 		4 TYR A  73
THR A  40
VAL A  70
ILE A  81
 None
 1.49A 4jx1F-3kxeA:
undetectable		 4jx1F-3kxeA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		4 TYR A 737
THR A 726
VAL A 730
ILE A 720
 None
 1.40A 4jx1F-3nawA:
undetectable		 4jx1F-3nawA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2

(Saccharomyces
cerevisiae) 		PF10193
(Telomere_reg-2) 		4 TYR A  90
THR A  73
VAL A 134
ILE A  78
 None
 1.30A 4jx1F-3o4zA:
undetectable		 4jx1F-3o4zA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qom 6-PHOSPHO-BETA-GLUCO
SIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		4 TYR A 420
THR A 400
VAL A 469
ILE A 406
 None
 0.97A 4jx1F-3qomA:
undetectable		 4jx1F-3qomA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxy NIF3 PROTEIN

(Sphaerobacter
thermophilus) 		no annotation 4 TYR A 258
THR A   6
VAL A  38
ILE A 132
 None
 1.36A 4jx1F-3rxyA:
undetectable		 4jx1F-3rxyA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ure ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes) 		PF00089
(Trypsin) 		4 TYR A  33
THR A  87
VAL A  84
ILE A  35
 None
 1.36A 4jx1F-3ureA:
undetectable		 4jx1F-3ureA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtc PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00106
(adh_short) 		4 TYR A 183
THR A  11
VAL A 117
ILE A 138
 None
 1.25A 4jx1F-3wtcA:
undetectable		 4jx1F-3wtcA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh0 PROTOGLOBIN

(Methanosarcina
acetivorans) 		PF11563
(Protoglobin) 		4 TYR A 105
THR A 178
VAL A  32
ILE A  42
 None
 1.13A 4jx1F-3zh0A:
undetectable		 4jx1F-3zh0A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak1 BT_4661

(Bacteroides
thetaiotaomicron) 		PF16319
(DUF4958) 		4 TYR A  17
THR A  67
VAL A  30
ILE A  63
 None
 1.31A 4jx1F-4ak1A:
undetectable		 4jx1F-4ak1A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq1 SBSB PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 4 TYR C 821
THR C 440
VAL C 777
ILE C 782
 None
 1.36A 4jx1F-4aq1C:
undetectable		 4jx1F-4aq1C:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5

(Escherichia
coli;
Macaca mulatta) 		PF00622
(SPRY)
PF01547
(SBP_bac_1) 		4 TYR A1480
THR A1350
VAL A1322
ILE A1376
 None
 0.89A 4jx1F-4b3nA:
undetectable		 4jx1F-4b3nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 TYR A 191
THR A 164
VAL A 425
ILE A 429
 None
 1.39A 4jx1F-4bjuA:
undetectable		 4jx1F-4bjuA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buh CLONE M0418 SCFV

(Homo sapiens) 		PF07686
(V-set) 		4 TYR A  27
THR A  78
VAL A   5
ILE A  34
 None
 1.40A 4jx1F-4buhA:
undetectable		 4jx1F-4buhA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs5 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Litopenaeus
vannamei) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 TYR A 249
THR A 219
VAL A 225
ILE A 247
 None
 1.33A 4jx1F-4cs5A:
undetectable		 4jx1F-4cs5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE

(Vibrio cholerae) 		no annotation 4 TYR A 183
THR A  90
VAL A   3
ILE A 205
 None
 0.99A 4jx1F-4evwA:
undetectable		 4jx1F-4evwA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TYR A1213
THR A1173
VAL A1189
ILE A1129
 None
 1.50A 4jx1F-4fxdA:
undetectable		 4jx1F-4fxdA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE

(Photorhabdus
laumondii) 		PF01494
(FAD_binding_3) 		4 TYR A  42
THR A 326
VAL A 244
ILE A  44
 FAD  A 501 (-3.5A)
None
None
FAD  A 501 (-4.4A)
 1.17A 4jx1F-4hb9A:
undetectable		 4jx1F-4hb9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		4 TYR A  85
THR A  48
VAL A  67
ILE A  87
 None
 1.49A 4jx1F-4maeA:
undetectable		 4jx1F-4maeA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 TYR A 333
THR A  79
VAL A 131
ILE A 335
 None
 1.44A 4jx1F-4mivA:
undetectable		 4jx1F-4mivA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqs GLYCOSIDE HYDROLASE
FAMILY 43

(Halothermothrix
orenii) 		PF04616
(Glyco_hydro_43) 		4 TYR A 272
THR A 286
VAL A   9
ILE A 251
 None
 1.43A 4jx1F-4qqsA:
undetectable		 4jx1F-4qqsA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2i ESTERASE/LIPASE

(Thalassospira
sp. GB04J01) 		PF07859
(Abhydrolase_3) 		4 TYR A 219
THR A 232
VAL A 188
ILE A 128
 None
 1.46A 4jx1F-4v2iA:
undetectable		 4jx1F-4v2iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnr LEUCINE-RICH-REPEAT
PROTEIN

(Methanosarcina
barkeri) 		PF08477
(Roc)
PF16095
(COR) 		4 TYR A 597
THR A 559
VAL A 552
ILE A 605
 None
 1.44A 4jx1F-4wnrA:
undetectable		 4jx1F-4wnrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 TYR A 248
THR A 171
VAL A 183
ILE A 166
 None
 1.23A 4jx1F-4yaiA:
undetectable		 4jx1F-4yaiA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 TYR A1328
THR A1257
VAL A1249
ILE A1383
 None
 1.35A 4jx1F-5a55A:
undetectable		 4jx1F-5a55A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		4 TYR A  53
THR A 235
VAL A 290
ILE A 347
 None
 1.45A 4jx1F-5aexA:
undetectable		 4jx1F-5aexA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 4 TYR A 267
THR A 249
VAL A 125
ILE A 288
 None
 1.23A 4jx1F-5ah1A:
undetectable		 4jx1F-5ah1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmr EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Mus musculus) 		PF03465
(eRF1_3) 		4 TYR B 290
THR B 308
VAL B 322
ILE B 412
 None
 1.47A 4jx1F-5dmrB:
undetectable		 4jx1F-5dmrB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Homo sapiens) 		PF00149
(Metallophos) 		4 TYR A 282
THR A 236
VAL A 247
ILE A 278
 None
 1.07A 4jx1F-5ebbA:
undetectable		 4jx1F-5ebbA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		4 TYR A 279
THR A 233
VAL A 244
ILE A 275
 None
 1.07A 4jx1F-5fcaA:
undetectable		 4jx1F-5fcaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 TYR A 307
THR A 359
VAL A 326
ILE A 775
 None
 1.30A 4jx1F-5im3A:
undetectable		 4jx1F-5im3A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8r PROTOCADHERIN
GAMMA-B3

(Homo sapiens) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 TYR A 285
THR A 273
VAL A 231
ILE A 307
 None
 1.44A 4jx1F-5k8rA:
undetectable		 4jx1F-5k8rA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lst ATP-DEPENDENT DNA
HELICASE Q4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 TYR A 621
THR A 580
VAL A 585
ILE A 604
 None
 1.38A 4jx1F-5lstA:
undetectable		 4jx1F-5lstA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B
HETERODISULFIDE
REDUCTASE, SUBUNIT C

(Methanothermococcus
thermolithotrophicus;
Methanothermococcus
thermolithotrophicus) 		PF02754
(CCG)
PF13183
(Fer4_8) 		4 TYR C  52
THR C  79
VAL B 200
ILE C  74
 SF4  C 202 (-4.9A)
None
None
None
 0.88A 4jx1F-5odrC:
undetectable		 4jx1F-5odrC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oee LARGE SUBUNIT
TERMINASE

(Phage D6E) 		no annotation 4 TYR A 238
THR A 359
VAL A 411
ILE A 354
 None
 1.44A 4jx1F-5oeeA:
undetectable		 4jx1F-5oeeA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufy ACYLTRANSFERASE

(Streptococcus
pneumoniae) 		no annotation 4 TYR A 586
THR A 517
VAL A 556
ILE A 590
 None
 1.11A 4jx1F-5ufyA:
undetectable		 4jx1F-5ufyA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ug1 ACYLTRANSFERASE

(Streptococcus
pneumoniae) 		no annotation 4 TYR A 586
THR A 517
VAL A 556
ILE A 590
 None
 1.13A 4jx1F-5ug1A:
undetectable		 4jx1F-5ug1A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulu CADHERIN-23

(Mus musculus) 		no annotation 4 TYR A2117
THR A2108
VAL A2104
ILE A2141
 None
 1.35A 4jx1F-5uluA:
undetectable		 4jx1F-5uluA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnn PHOSPHATE-BINDING
PROTEIN PSTS

(Burkholderia
pseudomallei) 		PF12849
(PBP_like_2) 		4 TYR A 124
THR A 192
VAL A 200
ILE A 211
 None
 1.48A 4jx1F-5wnnA:
undetectable		 4jx1F-5wnnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4r S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 TYR A 231
THR A 202
VAL A 102
ILE A  31
 None
 1.46A 4jx1F-5x4rA:
undetectable		 4jx1F-5x4rA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		4 TYR A 231
THR A 202
VAL A 102
ILE A  31
 None
 1.46A 4jx1F-5x59A:
undetectable		 4jx1F-5x59A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zov -

(-) 		no annotation 4 TYR A  87
THR A 285
VAL A  55
ILE A 280
 ASC  A 501 (-4.0A)
None
None
None
 1.08A 4jx1F-5zovA:
undetectable		 4jx1F-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 TYR A 104
THR A 155
VAL A 125
ILE A 584
 None
 1.38A 4jx1F-6cgmA:
undetectable		 4jx1F-6cgmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 4 TYR A 208
THR A 265
VAL A 298
ILE A 278
 None
 1.18A 4jx1F-6et7A:
undetectable		 4jx1F-6et7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpd PROTEIN AB21

(Agaricus
bisporus) 		no annotation 4 TYR A 190
THR A  80
VAL A 128
ILE A 194
 None
 1.48A 4jx1F-6fpdA:
undetectable		 4jx1F-6fpdA:
undetectable