SIMILAR PATTERNS OF AMINO ACIDS FOR 4JX1_E_CAME502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 PHE A 396
THR A 295
PHE A 301
ILE A 393
 None
 1.23A 4jx1E-1bp1A:
0.0		 4jx1E-1bp1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 PHE A 515
TYR A 511
THR A 457
PHE A 455
 None
 1.19A 4jx1E-1eovA:
undetectable		 4jx1E-1eovA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		4 PHE A 178
THR A 146
PHE A 116
ILE A 226
 None
 1.26A 4jx1E-1f5nA:
0.0		 4jx1E-1f5nA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		4 TYR A 128
THR A 146
PHE A 116
ILE A 226
 None
 1.04A 4jx1E-1f5nA:
0.0		 4jx1E-1f5nA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fml RETINOL DEHYDRATASE

(Spodoptera
frugiperda) 		PF00685
(Sulfotransfer_1) 		4 PHE A 228
TYR A 227
PHE A 217
ILE A 335
 None
 1.21A 4jx1E-1fmlA:
0.0		 4jx1E-1fmlA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcw PROTEIN (HEMOGLOBIN)

(Mustelus
griseus) 		PF00042
(Globin) 		4 PHE B  75
THR B  97
PHE B 123
ILE B 131
 None
HEM  B 136 ( 4.6A)
None
HEM  B 136 (-4.2A)
 1.25A 4jx1E-1gcwB:
0.9		 4jx1E-1gcwB:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		4 PHE A 395
THR A 479
PHE A 400
ILE A 475
 None
None
None
GOL  A 612 (-3.3A)
 1.22A 4jx1E-1gq1A:
undetectable		 4jx1E-1gq1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		4 PHE A 176
TYR A 173
PHE A 263
ILE A 195
 None
 1.14A 4jx1E-1kgpA:
0.1		 4jx1E-1kgpA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh0 PROTEIN L

(Finegoldia
magna) 		PF02246
(B1) 		4 TYR A  36
THR A  19
PHE A  22
ILE A  62
 None
 1.25A 4jx1E-1kh0A:
undetectable		 4jx1E-1kh0A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 PHE A 118
THR A 114
PHE A 108
ILE A 132
 None
 1.17A 4jx1E-1macA:
0.0		 4jx1E-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmy PROTEASE

(Foot-and-mouth
disease virus) 		PF05408
(Peptidase_C28) 		4 PHE A 151
TYR A  62
THR A  40
ILE A 162
 None
 1.13A 4jx1E-1qmyA:
undetectable		 4jx1E-1qmyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		4 PHE A 166
TYR A 163
PHE A 253
ILE A 185
 None
 1.16A 4jx1E-1r2fA:
undetectable		 4jx1E-1r2fA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 PHE B 460
THR B 441
PHE B 444
ILE B 436
 None
 1.12A 4jx1E-1skyB:
undetectable		 4jx1E-1skyB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 PHE A 691
TYR A 743
THR A 619
ILE A 690
 None
 1.14A 4jx1E-1vbgA:
undetectable		 4jx1E-1vbgA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 PHE A 248
THR A 183
PHE A 185
ILE A 178
 None
 1.22A 4jx1E-1w27A:
undetectable		 4jx1E-1w27A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280

(Thermus
thermophilus) 		PF10672
(Methyltrans_SAM) 		4 PHE A 208
TYR A 204
THR A 323
ILE A 320
 None
 0.89A 4jx1E-1wxxA:
undetectable		 4jx1E-1wxxA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4e RNA BINDING MOTIF,
SINGLE-STRANDED
INTERACTING PROTEIN
2

(Homo sapiens) 		PF00076
(RRM_1) 		4 TYR A  29
THR A  35
PHE A  54
ILE A  10
 None
 1.14A 4jx1E-1x4eA:
undetectable		 4jx1E-1x4eA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvd RAS-RELATED PROTEIN
RAB-22A

(Mus musculus) 		PF00071
(Ras) 		4 TYR A 136
THR A  95
PHE A  93
ILE A  83
 None
 1.22A 4jx1E-1yvdA:
undetectable		 4jx1E-1yvdA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb5 HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Bacillus cereus) 		PF02457
(DisA_N)
PF10372
(YojJ) 		4 PHE A 194
TYR A  69
THR A  63
ILE A 203
 None
 1.03A 4jx1E-2fb5A:
undetectable		 4jx1E-2fb5A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcr FLAVODOXIN

(Chondrus
crispus) 		PF00258
(Flavodoxin_1) 		4 PHE A   5
THR A  38
PHE A  72
ILE A  32
 None
 1.15A 4jx1E-2fcrA:
undetectable		 4jx1E-2fcrA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gai DNA TOPOISOMERASE I

(Thermotoga
maritima) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 PHE A 553
THR A 488
PHE A 574
ILE A 594
 None
 1.26A 4jx1E-2gaiA:
undetectable		 4jx1E-2gaiA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		4 PHE A 445
TYR A 446
THR A 194
ILE A 197
 None
 0.76A 4jx1E-2gfiA:
undetectable		 4jx1E-2gfiA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)

(Homo sapiens) 		PF00059
(Lectin_C) 		4 TYR B 175
THR B 211
PHE B 177
ILE B 201
 None
 1.09A 4jx1E-2h2tB:
undetectable		 4jx1E-2h2tB:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk7 SHIKIMATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 PHE A  55
THR A  66
PHE A  69
ILE A  63
 None
 1.02A 4jx1E-2hk7A:
undetectable		 4jx1E-2hk7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 PHE A 269
THR A 198
PHE A 196
ILE A 298
 None
None
P6G  A 503 (-4.7A)
None
 1.14A 4jx1E-2incA:
undetectable		 4jx1E-2incA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix2 DNA POLYMERASE
SLIDING CLAMP B

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N) 		4 PHE A  12
THR A  92
PHE A  30
ILE A  89
 None
 1.26A 4jx1E-2ix2A:
undetectable		 4jx1E-2ix2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbr P-HYDROXYPHENYLACETA
TE HYDROXYLASE C2
OXYGENASE COMPONENT

(Acinetobacter
baumannii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 PHE A 196
TYR A 262
THR A 119
ILE A 180
 None
 1.24A 4jx1E-2jbrA:
undetectable		 4jx1E-2jbrA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3t TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14633
(SH2_2) 		4 PHE A  30
TYR A   9
PHE A  11
ILE A  44
 None
 1.26A 4jx1E-2l3tA:
undetectable		 4jx1E-2l3tA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqo GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		4 PHE A 211
THR A 179
PHE A 187
ILE A 172
 None
 1.19A 4jx1E-2nqoA:
undetectable		 4jx1E-2nqoA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v73 PUTATIVE
EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF02973
(Sialidase) 		4 PHE A  32
THR A  39
PHE A 135
ILE A   8
 None
 1.26A 4jx1E-2v73A:
undetectable		 4jx1E-2v73A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 PHE A 457
TYR A 456
PHE A 452
ILE A 293
 None
 1.17A 4jx1E-2xpzA:
undetectable		 4jx1E-2xpzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 TYR A  94
THR A  73
PHE A  96
ILE A  80
 None
 1.25A 4jx1E-2xr1A:
undetectable		 4jx1E-2xr1A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 PHE A 727
TYR A 955
THR A 768
ILE A 764
 None
 1.00A 4jx1E-2zaiA:
undetectable		 4jx1E-2zaiA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo6 CYAN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN (KCY)

(Verrillofungia
concinna) 		PF01353
(GFP) 		4 PHE A  54
THR A  45
PHE A  23
ILE A 204
 None
 1.06A 4jx1E-2zo6A:
undetectable		 4jx1E-2zo6A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo7 CYAN/GREEN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN MUTANT
(KCY-R1)

(Verrillofungia
concinna) 		PF01353
(GFP) 		4 PHE A  55
THR A  46
PHE A  24
ILE A 205
 None
 1.09A 4jx1E-2zo7A:
undetectable		 4jx1E-2zo7A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 PHE A 634
THR A1242
PHE A1246
ILE A 639
 None
 1.09A 4jx1E-3av6A:
undetectable		 4jx1E-3av6A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		4 PHE A  41
TYR A 128
PHE A 114
ILE A  57
 None
GOL  A 145 (-4.7A)
None
None
 1.26A 4jx1E-3b8lA:
undetectable		 4jx1E-3b8lA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli) 		PF01343
(Peptidase_S49) 		4 TYR A 149
THR A 296
PHE A 299
ILE A 291
 None
 1.26A 4jx1E-3bf0A:
undetectable		 4jx1E-3bf0A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl9 SCAVENGER
MRNA-DECAPPING
ENZYME DCPS

(Homo sapiens) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		4 PHE A 319
TYR A 269
THR A 154
ILE A 151
 None
 1.22A 4jx1E-3bl9A:
undetectable		 4jx1E-3bl9A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 PHE A 204
THR A 122
PHE A 125
ILE A  86
 None
 1.18A 4jx1E-3c9bA:
undetectable		 4jx1E-3c9bA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 PHE A 191
THR A 278
PHE A 159
ILE A 447
 None
HEM  A 500 (-4.2A)
None
None
 1.05A 4jx1E-3dbgA:
30.1		 4jx1E-3dbgA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga7 ACETYL ESTERASE

(Salmonella
enterica) 		PF07859
(Abhydrolase_3) 		4 PHE A 145
TYR A 144
THR A  73
ILE A 119
 None
 1.22A 4jx1E-3ga7A:
undetectable		 4jx1E-3ga7A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grw FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07679
(I-set) 		4 PHE A 195
TYR A 226
PHE A 174
ILE A 204
 None
 0.93A 4jx1E-3grwA:
undetectable		 4jx1E-3grwA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7f ASPARTYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 PHE A 502
TYR A 498
THR A 446
PHE A 444
 None
 1.19A 4jx1E-3i7fA:
undetectable		 4jx1E-3i7fA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 C381 TURRET PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 PHE P 197
TYR P 245
THR P 189
ILE P 216
 None
 1.22A 4jx1E-3j31P:
undetectable		 4jx1E-3j31P:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 PHE A 380
TYR A 376
THR A 326
PHE A 324
 None
 1.13A 4jx1E-3kfuA:
undetectable		 4jx1E-3kfuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 PHE B 115
TYR B 116
PHE B 120
ILE B 269
 None
 0.95A 4jx1E-3lcvB:
undetectable		 4jx1E-3lcvB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00102
(Y_phosphatase) 		4 TYR A 284
THR A 255
PHE A   7
ILE A 262
 None
 1.05A 4jx1E-3m4uA:
undetectable		 4jx1E-3m4uA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqk UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		4 PHE A  35
THR A 118
PHE A 115
ILE A  65
 None
None
EDO  A 402 (-3.9A)
None
 1.02A 4jx1E-3nqkA:
undetectable		 4jx1E-3nqkA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7o ENDOGLUCANASE

(Thermotoga
maritima) 		PF01670
(Glyco_hydro_12) 		4 PHE A 114
THR A  46
PHE A  69
ILE A 104
 None
 1.12A 4jx1E-3o7oA:
undetectable		 4jx1E-3o7oA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otd TRNA(HIS)
GUANYLYLTRANSFERASE

(Homo sapiens) 		PF04446
(Thg1)
PF14413
(Thg1C) 		4 TYR A  78
THR A  60
PHE A 104
ILE A  68
 None
 1.25A 4jx1E-3otdA:
undetectable		 4jx1E-3otdA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p40 NEUROFASCIN

(Homo sapiens) 		PF13927
(Ig_3) 		4 PHE A  82
TYR A 116
THR A  98
ILE A  84
 None
 1.09A 4jx1E-3p40A:
undetectable		 4jx1E-3p40A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppu GLUTATHIONE-S-TRANSF
ERASE

(Phanerochaete
chrysosporium) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 PHE A 285
TYR A 223
PHE A  54
ILE A 333
 None
 0.78A 4jx1E-3ppuA:
undetectable		 4jx1E-3ppuA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q35 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 PHE B 204
THR B 122
PHE B 125
ILE B  86
 None
 1.21A 4jx1E-3q35B:
undetectable		 4jx1E-3q35B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slg PBGP3 PROTEIN

(Burkholderia
pseudomallei) 		PF01370
(Epimerase) 		4 PHE A 224
THR A 200
PHE A 202
ILE A 181
 None
 1.14A 4jx1E-3slgA:
undetectable		 4jx1E-3slgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu1 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0242

(Pyrococcus
horikoshii) 		no annotation 4 PHE A 733
TYR A 961
THR A 774
ILE A 770
 None
 0.98A 4jx1E-3vu1A:
undetectable		 4jx1E-3vu1A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 4 PHE A 442
TYR A 441
THR A 434
ILE A 335
 None
 1.03A 4jx1E-3w36A:
undetectable		 4jx1E-3w36A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wov OLIGOSACCHARYL
TRANSFERASE

(Pyrococcus
abyssi) 		no annotation 4 PHE A 735
TYR A 961
THR A 776
ILE A 772
 None
 0.95A 4jx1E-3wovA:
undetectable		 4jx1E-3wovA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR

(Homo sapiens) 		PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10) 		4 PHE A 360
TYR A 424
THR A 449
ILE A 374
 None
 1.18A 4jx1E-3wsyA:
undetectable		 4jx1E-3wsyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN

(Caenorhabditis
elegans) 		no annotation 4 PHE A  72
THR A  87
PHE A  89
ILE A  82
 None
 1.18A 4jx1E-3zheA:
undetectable		 4jx1E-3zheA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zw5 GLYOXALASE
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00903
(Glyoxalase) 		4 PHE A  68
TYR A  43
THR A  32
ILE A  29
 None
 1.21A 4jx1E-3zw5A:
undetectable		 4jx1E-3zw5A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2f PUTATIVE ANTIGEN P35

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		4 PHE A 147
THR A 163
PHE A 126
ILE A 158
 None
 1.20A 4jx1E-4b2fA:
undetectable		 4jx1E-4b2fA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		4 PHE A 207
TYR A  19
THR A 110
ILE A 113
 None
 1.15A 4jx1E-4be9A:
undetectable		 4jx1E-4be9A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		4 PHE A 169
TYR A 166
PHE A 256
ILE A 188
 None
 1.13A 4jx1E-4bmrA:
undetectable		 4jx1E-4bmrA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
subtilis) 		PF00268
(Ribonuc_red_sm) 		4 PHE A 172
TYR A 169
PHE A 259
ILE A 191
 None
 1.13A 4jx1E-4dr0A:
undetectable		 4jx1E-4dr0A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		4 PHE A 139
TYR A 136
THR A  49
ILE A 211
 None
 1.18A 4jx1E-4f7aA:
undetectable		 4jx1E-4f7aA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 PHE A 384
TYR A 394
THR A 245
ILE A 242
 None
 1.22A 4jx1E-4flnA:
undetectable		 4jx1E-4flnA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwb HALOALKANE
DEHALOGENASE

(Rhodococcus
rhodochrous) 		PF00561
(Abhydrolase_1) 		4 PHE A 245
TYR A 176
PHE A 273
ILE A 246
 CL  A2003 ( 4.7A)
CL  A2005 (-4.3A)
CL  A2005 ( 4.8A)
CL  A2003 ( 3.9A)
 0.95A 4jx1E-4fwbA:
undetectable		 4jx1E-4fwbA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		4 TYR A 134
THR A  19
PHE A  20
ILE A  27
 None
 1.15A 4jx1E-4gniA:
undetectable		 4jx1E-4gniA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN

(Streptococcus
gordonii) 		no annotation 4 TYR D 416
THR D 394
PHE D 362
ILE D 388
 None
 1.09A 4jx1E-4igbD:
undetectable		 4jx1E-4igbD:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igo OS05G0196500 PROTEIN

(Oryza sativa) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 PHE A 287
TYR A 286
PHE A 282
ILE A 302
 None
 1.12A 4jx1E-4igoA:
undetectable		 4jx1E-4igoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6p LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR

(Homo sapiens) 		PF00059
(Lectin_C) 		4 TYR A 175
THR A 211
PHE A 177
ILE A 201
 None
 1.04A 4jx1E-4j6pA:
undetectable		 4jx1E-4j6pA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Thermobifida
fusca) 		PF02011
(Glyco_hydro_48) 		4 TYR A 203
THR A 186
PHE A 207
ILE A 587
 None
 1.26A 4jx1E-4jjjA:
undetectable		 4jx1E-4jjjA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jp6 PAPAYA BARWIN-LIKE
PROTEIN

(Carica papaya) 		PF00967
(Barwin) 		4 PHE A  49
TYR A 115
THR A  77
ILE A  80
 None
 1.17A 4jx1E-4jp6A:
undetectable		 4jx1E-4jp6A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8n PDZ DOMAIN PROTEIN

(Parabacteroides
distasonis) 		PF00595
(PDZ)
PF13590
(DUF4136) 		4 PHE A 450
TYR A 432
THR A 466
ILE A 463
 None
 1.11A 4jx1E-4l8nA:
undetectable		 4jx1E-4l8nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb8 UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF16140
(DUF4848) 		4 PHE A 168
TYR A 135
THR A 130
ILE A 127
 None
 0.94A 4jx1E-4lb8A:
undetectable		 4jx1E-4lb8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		4 PHE A 269
THR A 198
PHE A 196
ILE A 298
 None
 1.13A 4jx1E-4p1cA:
undetectable		 4jx1E-4p1cA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwv P450 MONOOXYGENASE

(Streptomyces
sp. Acta 2897) 		PF00067
(p450) 		4 PHE A 145
THR A 262
PHE A 381
ILE A 257
 None
 1.04A 4jx1E-4pwvA:
42.8		 4jx1E-4pwvA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdv M7GPPPX
DIPHOSPHATASE

(Homo sapiens) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		4 PHE A 319
TYR A 269
THR A 154
ILE A 151
 None
 1.23A 4jx1E-4qdvA:
undetectable		 4jx1E-4qdvA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rev DISEASE RESISTANCE
RESPONSE PROTEIN 206

(Pisum sativum) 		PF03018
(Dirigent) 		4 PHE A  36
THR A 116
PHE A 130
ILE A  83
 None
 1.12A 4jx1E-4revA:
undetectable		 4jx1E-4revA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG

(Homo sapiens) 		PF04049
(ANAPC8)
PF13181
(TPR_8)
PF13414
(TPR_11) 		4 PHE C  94
TYR C 120
THR C  43
PHE C 116
 None
 1.01A 4jx1E-4ui9C:
undetectable		 4jx1E-4ui9C:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgj BEPC PROTEIN

(Bartonella
tribocorum) 		PF02661
(Fic) 		4 PHE A 201
THR A 170
PHE A 131
ILE A 204
 None
None
None
EDO  A 302 (-4.7A)
 0.83A 4jx1E-4wgjA:
undetectable		 4jx1E-4wgjA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		4 PHE A 203
THR A 173
PHE A 177
ILE A 202
 None
 1.19A 4jx1E-4y23A:
undetectable		 4jx1E-4y23A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 PHE A 625
TYR A 853
THR A 666
ILE A 662
 None
 1.00A 4jx1E-5azaA:
undetectable		 4jx1E-5azaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edv E3 UBIQUITIN-PROTEIN
LIGASE RNF31

(Homo sapiens) 		PF01485
(IBR) 		4 PHE A 762
TYR A 761
THR A 753
ILE A 739
 None
 1.25A 4jx1E-5edvA:
undetectable		 4jx1E-5edvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gve DNA TOPOISOMERASE
3-BETA-1

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 PHE A 200
TYR A 199
PHE A 195
ILE A 212
 None
 1.21A 4jx1E-5gveA:
undetectable		 4jx1E-5gveA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9x BETA-1,3-GLUCANASE

(Paenibacillus
barengoltzii) 		PF16483
(Glyco_hydro_64) 		4 PHE A 326
TYR A 325
PHE A 316
ILE A 337
 None
 1.26A 4jx1E-5h9xA:
undetectable		 4jx1E-5h9xA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		4 PHE A 164
THR A 137
PHE A 139
ILE A 132
 None
 0.94A 4jx1E-5ikzA:
undetectable		 4jx1E-5ikzA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1u NAD(P)H:FLAVIN
OXIDOREDUCTASE SYE4

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		4 TYR A 240
THR A 285
PHE A 279
ILE A 270
 TNF  A 402 (-4.5A)
None
None
None
 1.14A 4jx1E-5k1uA:
undetectable		 4jx1E-5k1uA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR

(Homo sapiens) 		PF00059
(Lectin_C) 		4 TYR E 175
THR E 211
PHE E 177
ILE E 201
 None
 1.14A 4jx1E-5lgkE:
undetectable		 4jx1E-5lgkE:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1

(Sorangium
cellulosum) 		PF00067
(p450) 		4 PHE A  88
TYR A 426
PHE A  69
ILE A  92
 None
 1.19A 4jx1E-5livA:
38.7		 4jx1E-5livA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 PHE A 305
TYR A 224
PHE A  13
ILE A 353
 None
 0.86A 4jx1E-5lkdA:
undetectable		 4jx1E-5lkdA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb9 PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		4 TYR A 134
THR A  19
PHE A  20
ILE A  27
 None
 1.12A 4jx1E-5mb9A:
undetectable		 4jx1E-5mb9A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mso CARBOXYLIC ACID
REDUCTASE

(Mycobacterium
marinum) 		PF07993
(NAD_binding_4) 		4 PHE A1074
TYR A1033
THR A1003
ILE A1161
 None
 1.16A 4jx1E-5msoA:
undetectable		 4jx1E-5msoA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		4 TYR A 122
THR A 169
PHE A 172
ILE A 184
 None
 1.23A 4jx1E-5mzoA:
undetectable		 4jx1E-5mzoA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udm PHAGE-ASSOCIATED
CELL WALL HYDROLASE

(Streptococcus
pyogenes) 		no annotation 4 TYR B  10
THR B  39
PHE B  42
ILE B  94
 None
 1.11A 4jx1E-5udmB:
undetectable		 4jx1E-5udmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens;
Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 PHE B 435
TYR A 369
THR A 428
PHE A 367
 None
 0.79A 4jx1E-5y3rB:
undetectable		 4jx1E-5y3rB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbi PEPTIDE ASPARAGINYL
LIGASE

(Viola
canadensis) 		no annotation 4 PHE A 441
THR A 423
PHE A 424
ILE A 445
 None
 1.17A 4jx1E-5zbiA:
undetectable		 4jx1E-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 4 TYR A 263
THR A 393
PHE A 270
ILE A 518
 None
None
None
EDO  A 604 (-3.8A)
 0.97A 4jx1E-6begA:
undetectable		 4jx1E-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsp U4 LIGHT CHAIN

(Mus musculus) 		no annotation 4 PHE B  62
TYR B  86
THR B  20
ILE B  75
 None
 0.82A 4jx1E-6bspB:
undetectable		 4jx1E-6bspB:
undetectable