SIMILAR PATTERNS OF AMINO ACIDS FOR 4JVL_A_ESTA702_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9k PROTEIN
(ALPHA-ADAPTIN
APPENDAGE DOMAIN)

(Mus musculus) 		PF02296
(Alpha_adaptin_C)
PF02883
(Alpha_adaptinC2) 		4 PHE A 795
PHE A 730
ILE A 787
MET A 737
 None
 1.25A 4jvlA-1b9kA:
0.0		 4jvlA-1b9kA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 TYR A 280
PHE A 426
ILE A 476
MET A 276
 LYS  A 505 (-4.6A)
LYS  A 505 (-3.7A)
None
LYS  A 505 ( 4.9A)
 1.19A 4jvlA-1bbuA:
0.0		 4jvlA-1bbuA:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bo6 ESTROGEN
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		5 CYH A  84
LYS A 106
HIS A 108
PHE A 142
MET A 248
 None
VO4  A 302 (-3.0A)
VO4  A 302 (-3.9A)
VO4  A 302 ( 4.6A)
None
 0.62A 4jvlA-1bo6A:
44.6		 4jvlA-1bo6A:
77.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bo6 ESTROGEN
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		4 LYS A 106
PHE A 255
ILE A 146
MET A 248
 VO4  A 302 (-3.0A)
A3P  A 301 ( 4.6A)
None
None
 1.06A 4jvlA-1bo6A:
44.6		 4jvlA-1bo6A:
77.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)

(Pneumocystis
carinii) 		PF00303
(Thymidylat_synt) 		4 CYH A 177
HIS A 174
ILE A 221
MET A 220
 None
 1.25A 4jvlA-1ci7A:
0.0		 4jvlA-1ci7A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g3m ESTROGEN
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		8 TYR A  20
PHE A  80
CYH A  83
LYS A 105
HIS A 107
PHE A 141
ILE A 246
MET A 247
 PCQ  A 712 (-3.9A)
PCQ  A 712 (-4.6A)
None
PCQ  A 712 (-3.0A)
PCQ  A 712 (-3.9A)
PCQ  A 712 (-4.7A)
PCQ  A 712 (-4.3A)
None
 0.24A 4jvlA-1g3mA:
50.3		 4jvlA-1g3mA:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		4 PHE A 706
CYH A 695
PHE A 788
ILE A 720
 None
 1.18A 4jvlA-1h7wA:
0.0		 4jvlA-1h7wA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 PHE A 390
PHE A 371
ILE A 351
MET A 348
 None
 1.35A 4jvlA-1igrA:
0.0		 4jvlA-1igrA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		4 PHE A 165
CYH A 305
PHE A 333
ILE A 172
 None
 1.32A 4jvlA-1l1lA:
0.0		 4jvlA-1l1lA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t62 CONSERVED
HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF04266
(ASCH) 		4 PHE A1124
HIS A1120
PHE A1102
ILE A1092
 None
 1.37A 4jvlA-1t62A:
0.0		 4jvlA-1t62A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Helicobacter
pylori) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 PHE A 405
CYH A 427
PHE A 367
ILE A 436
 None
 1.23A 4jvlA-1um8A:
undetectable		 4jvlA-1um8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v29 NITRILE HYDRATASE B
CHAIN

(Bacillus
smithii) 		PF02211
(NHase_beta) 		4 TYR B  72
PHE B  36
PHE B  55
ILE B  77
 None
 1.17A 4jvlA-1v29B:
undetectable		 4jvlA-1v29B:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v47 ATP SULFURYLASE

(Thermus
thermophilus) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 TYR A 208
HIS A 168
PHE A 161
ILE A 190
 None
ADX  A 564 (-4.7A)
ADX  A 564 (-4.6A)
None
 1.27A 4jvlA-1v47A:
undetectable		 4jvlA-1v47A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vka MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		4 PHE A  75
PHE A 111
ILE A  56
MET A  48
 None
 1.30A 4jvlA-1vkaA:
undetectable		 4jvlA-1vkaA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhp CALCIUM-DEPENDENT
CELL ADHESION
MOLECULE-1

(Dictyostelium
discoideum) 		PF08964
(Crystall_3)
PF14564
(Membrane_bind) 		4 TYR A  23
PHE A  12
PHE A  31
ILE A  54
 None
 1.32A 4jvlA-1yhpA:
undetectable		 4jvlA-1yhpA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0a RAS-RELATED PROTEIN
RAB-2A

(Homo sapiens) 		PF00071
(Ras) 		4 TYR A   9
PHE A  26
ILE A 117
MET A 146
 None
 1.13A 4jvlA-1z0aA:
undetectable		 4jvlA-1z0aA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A 483
PHE A 504
ILE A 489
MET A 490
 None
 1.36A 4jvlA-1zvdA:
undetectable		 4jvlA-1zvdA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5j RAS-RELATED PROTEIN
RAB-2B

(Homo sapiens) 		PF00071
(Ras) 		4 TYR A  14
PHE A  31
ILE A 122
MET A 151
 None
 1.10A 4jvlA-2a5jA:
undetectable		 4jvlA-2a5jA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		4 CYH A 191
HIS A 188
ILE A 238
MET A 237
 None
UMP  A 350 (-4.2A)
None
None
 1.14A 4jvlA-2aazA:
undetectable		 4jvlA-2aazA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 TYR B 102
PHE B 230
HIS B 193
ILE B 473
 None
 1.08A 4jvlA-2afhB:
2.8		 4jvlA-2afhB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
BETA SUBUNIT

(Bacillus sp.
RAPc8) 		PF02211
(NHase_beta) 		4 TYR B  72
PHE B  36
PHE B  55
ILE B  77
 None
 1.12A 4jvlA-2dppB:
undetectable		 4jvlA-2dppB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		4 TYR A 117
PHE A 125
CYH A 120
ILE A 386
 None
 0.98A 4jvlA-2g28A:
undetectable		 4jvlA-2g28A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 PHE A 445
LYS A 222
PHE A 274
ILE A 311
 XYQ  A1222 ( 4.5A)
XYQ  A1222 (-1.3A)
NCA  A 900 ( 3.9A)
None
 1.06A 4jvlA-2hjhA:
undetectable		 4jvlA-2hjhA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 TYR A 117
PHE A  81
PHE A 217
ILE A 296
 None
 1.17A 4jvlA-2iqfA:
undetectable		 4jvlA-2iqfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 TYR A 337
LYS A  54
HIS A  54
PHE A 140
 HEM  A 486 (-4.1A)
OMT  A  53 (-3.0A)
HEM  A 486 (-3.4A)
HEM  A 486 (-3.4A)
 1.35A 4jvlA-2isaA:
undetectable		 4jvlA-2isaA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 PHE A  93
PHE A 226
ILE A 216
MET A 148
 None
 1.16A 4jvlA-2it4A:
undetectable		 4jvlA-2it4A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 TYR X  10
CYH X 588
HIS X 585
ILE X 430
 None
2MD  X 801 (-4.2A)
None
2MD  X 801 (-4.2A)
 1.24A 4jvlA-2iv2X:
undetectable		 4jvlA-2iv2X:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		4 TYR A 145
CYH A 126
HIS A  21
ILE A 252
 None
 1.17A 4jvlA-2pq6A:
undetectable		 4jvlA-2pq6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 PHE A 216
HIS A 217
PHE A 244
ILE A  46
 HEM  A 501 (-4.0A)
None
ANJ  A 504 (-4.3A)
ANJ  A 504 (-4.6A)
 1.25A 4jvlA-2qjpA:
undetectable		 4jvlA-2qjpA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjz MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		4 PHE A  75
PHE A 111
ILE A  56
MET A  48
 None
 1.36A 4jvlA-2qjzA:
undetectable		 4jvlA-2qjzA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 PHE A 293
CYH A 298
PHE A  94
ILE A   7
 None
 1.37A 4jvlA-2qk4A:
undetectable		 4jvlA-2qk4A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1

(Sulfolobus
solfataricus) 		PF03070
(TENA_THI-4) 		4 HIS A  88
PHE A  40
ILE A  27
MET A  30
 None
 1.35A 4jvlA-2qzcA:
undetectable		 4jvlA-2qzcA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8u MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		4 PHE A  75
PHE A 111
ILE A  56
MET A  48
 None
 1.34A 4jvlA-2r8uA:
undetectable		 4jvlA-2r8uA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 PHE A 445
HIS A 421
PHE A 484
ILE A 490
 None
 1.21A 4jvlA-2rdyA:
undetectable		 4jvlA-2rdyA:
15.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2reo PUTATIVE
SULFOTRANSFERASE 1C3

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 HIS A 117
PHE A 151
ILE A 256
MET A 257
 None
 0.65A 4jvlA-2reoA:
30.8		 4jvlA-2reoA:
51.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN

(Rattus
norvegicus) 		PF00079
(Serpin) 		4 TYR A 170
PHE A 102
HIS A 143
MET A  49
 None
 1.31A 4jvlA-2v95A:
undetectable		 4jvlA-2v95A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wm4 PUTATIVE CYTOCHROME
P450 124

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 PHE A 129
PHE A 260
ILE A 111
MET A 110
 None
None
HEM  A 450 (-4.3A)
HEM  A 450 ( 4.4A)
 1.16A 4jvlA-2wm4A:
undetectable		 4jvlA-2wm4A:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zyv TYROSINE-ESTER
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		4 PHE X  81
LYS X 106
HIS X 108
ILE X  89
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1602 (-4.2A)
 1.27A 4jvlA-2zyvX:
44.9		 4jvlA-2zyvX:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zyv TYROSINE-ESTER
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		5 PHE X  81
LYS X 106
HIS X 108
PHE X 142
MET X 248
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 0.32A 4jvlA-2zyvX:
44.9		 4jvlA-2zyvX:
56.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9n ALKANE MONOOXYGENASE

(Geobacillus
thermodenitrificans) 		PF00296
(Bac_luciferase) 		4 PHE A 278
HIS A   6
PHE A 417
ILE A 224
 None
 1.32A 4jvlA-3b9nA:
undetectable		 4jvlA-3b9nA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cei SUPEROXIDE DISMUTASE

(Helicobacter
pylori) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 TYR A  76
PHE A   9
PHE A  17
ILE A 181
 None
 1.32A 4jvlA-3ceiA:
undetectable		 4jvlA-3ceiA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckl SULFOTRANSFERASE
FAMILY CYTOSOLIC 1B
MEMBER 1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 LYS A 107
HIS A 109
PHE A 143
MET A 249
 A3P  A 601 ( 4.8A)
STL  A 501 (-3.8A)
STL  A 501 (-4.6A)
None
 0.33A 4jvlA-3cklA:
44.0		 4jvlA-3cklA:
55.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 CYH A 941
HIS A 789
PHE A1030
ILE A1037
 None
 1.37A 4jvlA-3dy5A:
undetectable		 4jvlA-3dy5A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehe UDP-GLUCOSE
4-EPIMERASE (GALE-1)

(Archaeoglobus
fulgidus) 		PF01370
(Epimerase) 		4 TYR A 206
PHE A  12
HIS A  16
ILE A 178
 None
 1.10A 4jvlA-3eheA:
undetectable		 4jvlA-3eheA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 TYR A 535
HIS A 488
PHE A 494
ILE A 390
 GOL  A 912 ( 4.1A)
None
None
None
 1.36A 4jvlA-3fahA:
undetectable		 4jvlA-3fahA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		4 PHE A 400
CYH A 404
PHE A 339
ILE A 412
 None
 1.36A 4jvlA-3gf7A:
undetectable		 4jvlA-3gf7A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Schizosaccharomyces
pombe) 		PF01191
(RNA_pol_Rpb5_C)
PF03871
(RNA_pol_Rpb5_N) 		4 PHE E  41
HIS E  45
PHE E  76
ILE E 136
 None
 0.84A 4jvlA-3h0gE:
undetectable		 4jvlA-3h0gE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq0 CATECHOL
2,3-DIOXYGENASE

(Pseudomonas
alkylphenolica) 		PF00903
(Glyoxalase) 		4 TYR A  26
PHE A 219
ILE A 233
MET A 234
 None
 0.90A 4jvlA-3hq0A:
undetectable		 4jvlA-3hq0A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 473
LYS A 159
PHE A 523
ILE A 481
 None
 1.15A 4jvlA-3i4gA:
undetectable		 4jvlA-3i4gA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		4 PHE A 642
CYH A 643
PHE A 687
ILE A 629
 None
 0.86A 4jvlA-3ibjA:
undetectable		 4jvlA-3ibjA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ils AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF00975
(Thioesterase) 		4 TYR A1979
PHE A2089
CYH A1982
ILE A2058
 None
 1.03A 4jvlA-3ilsA:
undetectable		 4jvlA-3ilsA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf3 INVERTASE

(Schwanniomyces
occidentalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 TYR A  66
PHE A  55
PHE A 161
ILE A 138
 None
 1.33A 4jvlA-3kf3A:
undetectable		 4jvlA-3kf3A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg4 UNCHARACTERIZED
PROTEIN

([Mannheimia]
succiniciproducens) 		PF09704
(Cas_Cas5d) 		4 TYR A  28
LYS A  22
PHE A 203
ILE A 193
 None
 1.28A 4jvlA-3kg4A:
undetectable		 4jvlA-3kg4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		4 HIS A 294
PHE A 290
ILE A 105
MET A 106
 None
None
None
VNF  A 490 ( 3.8A)
 1.29A 4jvlA-3kswA:
undetectable		 4jvlA-3kswA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		4 TYR B 351
PHE B 297
ILE B 418
MET B 419
 None
 1.37A 4jvlA-3ml0B:
undetectable		 4jvlA-3ml0B:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis) 		PF01979
(Amidohydro_1) 		4 TYR A 122
PHE A 361
HIS A 228
ILE A  88
 None
 1.29A 4jvlA-3mpgA:
undetectable		 4jvlA-3mpgA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppo GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		4 PHE A 133
CYH A 243
ILE A  51
MET A  50
 None
 1.16A 4jvlA-3ppoA:
undetectable		 4jvlA-3ppoA:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qvu SULFOTRANSFERASE 1A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 PHE A  81
HIS A 108
PHE A 142
ILE A 243
 NPO  A 296 ( 4.7A)
NPO  A 296 (-3.7A)
NPO  A 296 (-4.8A)
None
 0.92A 4jvlA-3qvuA:
43.3		 4jvlA-3qvuA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qvu SULFOTRANSFERASE 1A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		6 PHE A  81
LYS A 106
HIS A 108
PHE A 142
ILE A 247
MET A 248
 NPO  A 296 ( 4.7A)
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 (-4.8A)
None
NPO  A 296 ( 4.3A)
 0.45A 4jvlA-3qvuA:
43.3		 4jvlA-3qvuA:
50.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE

(Paraburkholderia
xenovorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 319
LYS A 161
HIS A 123
PHE A  39
 None
FUM  A 500 (-3.3A)
FUM  A 500 (-4.0A)
None
 1.33A 4jvlA-3sn0A:
undetectable		 4jvlA-3sn0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3i NUCLEOCAPSID PROTEIN

(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 TYR A 260
PHE A 213
ILE A 277
MET A 276
 None
 1.33A 4jvlA-3u3iA:
undetectable		 4jvlA-3u3iA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujm RASPUTIN

(Drosophila
melanogaster) 		PF02136
(NTF2) 		4 TYR A  25
CYH A  71
PHE A 127
ILE A  63
 None
 1.33A 4jvlA-3ujmA:
undetectable		 4jvlA-3ujmA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		4 TYR A 182
HIS A 206
PHE A  78
ILE A  86
 None
FE  A 429 (-3.3A)
None
None
 1.28A 4jvlA-3v7pA:
undetectable		 4jvlA-3v7pA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 CYH A 554
HIS A 405
PHE A 643
ILE A 650
 None
 1.34A 4jvlA-3vf1A:
undetectable		 4jvlA-3vf1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa) 		PF12697
(Abhydrolase_6) 		4 PHE A 114
CYH A 105
HIS A 239
ILE A 152
 None
 1.22A 4jvlA-3w04A:
undetectable		 4jvlA-3w04A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2

(Homo sapiens) 		PF03006
(HlyIII) 		4 TYR A 321
HIS A 362
PHE A 231
ILE A 290
 None
 1.13A 4jvlA-3wxwA:
undetectable		 4jvlA-3wxwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LYS A 330
HIS A 107
ILE A 275
MET A 274
 None
 1.24A 4jvlA-4c3hA:
undetectable		 4jvlA-4c3hA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF12341
(Mcl1_mid) 		4 TYR A 526
PHE A 517
HIS A 559
PHE A 546
 None
 1.17A 4jvlA-4c95A:
undetectable		 4jvlA-4c95A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE

(Mycobacterium
tuberculosis) 		PF02585
(PIG-L) 		4 PHE A 109
CYH A  40
HIS A 149
ILE A 124
 None
 1.30A 4jvlA-4ewlA:
undetectable		 4jvlA-4ewlA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex5 LYSINE--TRNA LIGASE

(Burkholderia
thailandensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 TYR A 280
PHE A 430
ILE A 480
MET A 276
 LYS  A 601 (-4.5A)
LYS  A 601 (-3.5A)
None
None
 1.28A 4jvlA-4ex5A:
undetectable		 4jvlA-4ex5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvo LMO2349 PROTEIN

(Listeria
monocytogenes) 		PF00497
(SBP_bac_3) 		4 PHE A  84
HIS A 101
PHE A 123
ILE A 195
 HIS  A 703 ( 3.7A)
CSX  A 704 ( 4.5A)
CSX  A 704 ( 3.4A)
None
 1.30A 4jvlA-4gvoA:
undetectable		 4jvlA-4gvoA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5n SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA -
CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG CHIMERIC
CONSTRUCT

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 CYH B 174
PHE B 199
ILE B 206
MET B 202
 None
 1.03A 4jvlA-4i5nB:
undetectable		 4jvlA-4i5nB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig8 2'-5'-OLIGOADENYLATE
SYNTHASE 1

(Homo sapiens) 		PF01909
(NTP_transf_2)
PF10421
(OAS1_C) 		4 PHE A  40
CYH A  45
PHE A 119
ILE A  99
 None
 1.19A 4jvlA-4ig8A:
undetectable		 4jvlA-4ig8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		4 PHE A 220
CYH A 156
PHE A 199
ILE A 185
 None
 1.30A 4jvlA-4k17A:
undetectable		 4jvlA-4k17A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III

(Scadoxus
multiflorus) 		PF00704
(Glyco_hydro_18) 		4 TYR A 132
HIS A 126
PHE A  38
ILE A 120
 None
 1.16A 4jvlA-4n42A:
undetectable		 4jvlA-4n42A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nw4 LIPOPROTEIN S-LAYER
PROTEIN

(Enterococcus
faecalis) 		PF16103
(DUF4822) 		4 TYR A  90
HIS A 166
PHE A  99
ILE A 124
 None
SO4  A 402 (-3.9A)
SO4  A 402 (-4.0A)
None
 1.30A 4jvlA-4nw4A:
undetectable		 4jvlA-4nw4A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2t UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF16109
(DUF4827) 		4 TYR A 184
PHE A 122
ILE A 107
MET A  96
 None
 1.30A 4jvlA-4o2tA:
undetectable		 4jvlA-4o2tA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		4 TYR A 280
CYH A 277
PHE A 312
ILE A 196
 None
 1.16A 4jvlA-4qppA:
undetectable		 4jvlA-4qppA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2h STIV B204 ATPASE

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 TYR A  24
PHE A 188
HIS A 201
ILE A 134
 None
 1.01A 4jvlA-4r2hA:
undetectable		 4jvlA-4r2hA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN C CHAIN

(Glossoscolex
paulistus) 		PF00042
(Globin) 		4 PHE C 111
HIS C 100
PHE C  52
ILE C  45
 HEM  C 201 (-3.7A)
HEM  C 201 (-3.2A)
HEM  C 201 (-4.5A)
None
 1.08A 4jvlA-4u8uC:
undetectable		 4jvlA-4u8uC:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1

(Mus musculus) 		PF01501
(Glyco_transf_8) 		4 TYR A 305
PHE A 332
ILE A 252
MET A 292
 None
 1.01A 4jvlA-4wm0A:
undetectable		 4jvlA-4wm0A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4a MATERNAL EFFECT
PROTEIN OSKAR

(Drosophila
melanogaster) 		PF17182
(OSK) 		4 CYH A 533
HIS A 528
PHE A 568
ILE A 560
 None
 1.33A 4jvlA-5a4aA:
undetectable		 4jvlA-5a4aA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af7 ACYL-COA
DEHYDROGENASE

(Advenella
mimigardefordensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A 243
LYS A 152
PHE A 236
ILE A 226
 None
 1.23A 4jvlA-5af7A:
undetectable		 4jvlA-5af7A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avp L-RIBOSE ISOMERASE

(Geodermatophilus
obscurus) 		no annotation 4 LYS A 115
PHE A 194
ILE A  44
MET A  67
 MN  A 401 ( 3.9A)
None
None
None
 1.36A 4jvlA-5avpA:
undetectable		 4jvlA-5avpA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		4 PHE A1063
PHE A 771
ILE A 680
MET A 678
 None
 1.29A 4jvlA-5cjuA:
undetectable		 4jvlA-5cjuA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cog IRC4

(Saccharomyces
cerevisiae) 		PF08020
(DUF1706) 		4 TYR A  87
PHE A 157
LYS A 160
ILE A 148
 None
None
CL  A 202 (-4.9A)
None
 1.35A 4jvlA-5cogA:
undetectable		 4jvlA-5cogA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE
PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 TYR E 103
PHE M 103
HIS M 107
ILE M 123
 None
 1.29A 4jvlA-5fmgE:
undetectable		 4jvlA-5fmgE:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1t STAGE II SPORULATION
PROTEIN D

(Clostridioides
difficile) 		PF08486
(SpoIID) 		4 CYH A 146
HIS A  80
ILE A  75
MET A  88
 ZN  A 401 ( 2.3A)
None
None
None
 1.23A 4jvlA-5i1tA:
undetectable		 4jvlA-5i1tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jft CASPASE 3,
APOPTOSIS-RELATED
CYSTEINE PROTEASE A

(Danio rerio) 		PF00656
(Peptidase_C14) 		4 PHE A 161
CYH A 119
ILE A  99
MET A 100
 None
 1.22A 4jvlA-5jftA:
undetectable		 4jvlA-5jftA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k21 PYOCYANIN
DEMETHYLASE

(Mycolicibacterium
fortuitum) 		no annotation 4 PHE A 126
HIS A 121
PHE A  70
ILE A 106
 6QF  A 201 (-4.4A)
6QF  A 201 (-3.8A)
6QF  A 201 (-3.6A)
None
 1.24A 4jvlA-5k21A:
undetectable		 4jvlA-5k21A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lal DIRIGENT PROTEIN 6

(Arabidopsis
thaliana) 		PF03018
(Dirigent) 		4 PHE A 155
HIS A 127
PHE A  45
ILE A 133
 None
GLY  A 216 ( 3.6A)
GLY  A 216 ( 4.9A)
None
 1.34A 4jvlA-5lalA:
undetectable		 4jvlA-5lalA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3l EXTRACELLULAR
GLOBIN-3

(Lumbricus
terrestris) 		PF00042
(Globin) 		4 PHE C 113
HIS C 102
PHE C  54
ILE C  47
 HEM  C 201 (-3.9A)
HEM  C 201 (-3.6A)
HEM  C 201 ( 4.3A)
None
 1.29A 4jvlA-5m3lC:
undetectable		 4jvlA-5m3lC:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy7 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		4 PHE B 269
CYH B 396
HIS B 292
ILE B 383
 None
 1.28A 4jvlA-5sy7B:
undetectable		 4jvlA-5sy7B:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT FWDF

(Methanothermobacter
wolfeii) 		PF00037
(Fer4)
PF12838
(Fer4_7) 		4 TYR F 156
CYH F 157
HIS F 173
ILE F 209
 None
SF4  F 407 (-2.2A)
None
None
 1.18A 4jvlA-5t5iF:
undetectable		 4jvlA-5t5iF:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		4 CYH A 386
PHE A 268
ILE A 362
MET A 363
 7DY  A1210 (-3.8A)
7DY  A1210 ( 4.7A)
None
None
 1.37A 4jvlA-5u09A:
undetectable		 4jvlA-5u09A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 PHE G 376
HIS G 374
ILE G 424
MET G 426
 None
 1.37A 4jvlA-5um8G:
undetectable		 4jvlA-5um8G:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjh PERIOSTIN

(Homo sapiens) 		no annotation 4 PHE A 534
HIS A 622
PHE A 577
ILE A 584
 None
 1.11A 4jvlA-5yjhA:
undetectable		 4jvlA-5yjhA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 583
CYH A 726
PHE A 616
ILE A 645
 None
 1.19A 4jvlA-6c6lA:
undetectable		 4jvlA-6c6lA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccb GLYCOPROTEIN 120

(Human
immunodeficiency
virus 1) 		no annotation 4 PHE C 376
HIS C 374
ILE C 424
MET C 426
 None
 1.28A 4jvlA-6ccbC:
undetectable		 4jvlA-6ccbC:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 4 PHE A 126
HIS A 118
ILE A 199
MET A 198
 None
 1.22A 4jvlA-6g21A:
undetectable		 4jvlA-6g21A:
14.04