SIMILAR PATTERNS OF AMINO ACIDS FOR 4JUO_F_LFXF101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1be4 NUCLEOSIDE
DIPHOSPHATE
TRANSFERASE


(Bos taurus)
PF00334
(NDK)
3 SER A  99
GLY A 119
GLU A   5
None
0.62A 4juoA-1be4A:
undetectable
4juoC-1be4A:
undetectable
4juoA-1be4A:
16.94
4juoC-1be4A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)


(Aspergillus
nidulans)
PF01761
(DHQ_synthase)
3 SER A 246
GLY A 288
GLU A  81
None
None
NAD  A 400 (-2.8A)
0.47A 4juoA-1dqsA:
0.0
4juoC-1dqsA:
3.5
4juoA-1dqsA:
25.83
4juoC-1dqsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum)
PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim)
3 SER A 419
GLY A 241
GLU A 344
None
0.50A 4juoA-1fohA:
undetectable
4juoC-1fohA:
undetectable
4juoA-1fohA:
22.65
4juoC-1fohA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE


(Schizosaccharomyces
pombe)
PF03372
(Exo_endo_phos)
3 SER A 837
GLY A 739
GLU A 785
None
0.61A 4juoA-1i9zA:
0.0
4juoC-1i9zA:
undetectable
4juoA-1i9zA:
19.61
4juoC-1i9zA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION


(Escherichia
coli)
PF08943
(CsiD)
3 SER A  26
GLY A 271
GLU A 267
None
0.62A 4juoA-1jr7A:
0.0
4juoC-1jr7A:
undetectable
4juoA-1jr7A:
18.81
4juoC-1jr7A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3r CONSERVED PROTEIN
MT0001


(Methanothermobacter
thermautotrophicus)
PF02598
(Methyltrn_RNA_3)
3 SER A 177
GLY A  52
GLU A  17
None
0.60A 4juoA-1k3rA:
0.0
4juoC-1k3rA:
undetectable
4juoA-1k3rA:
24.47
4juoC-1k3rA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554)
PF12708
(Pectate_lyase_3)
3 SER A 300
GLY A 279
GLU A 310
None
0.49A 4juoA-1ktwA:
0.0
4juoC-1ktwA:
undetectable
4juoA-1ktwA:
21.56
4juoC-1ktwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6y S-ADENOSYL-METHYLTRA
NSFERASE MRAW


(Thermotoga
maritima)
PF01795
(Methyltransf_5)
3 SER A   5
GLY A  37
GLU A  70
None
SAH  A 401 (-3.3A)
None
0.59A 4juoA-1m6yA:
undetectable
4juoC-1m6yA:
undetectable
4juoA-1m6yA:
19.58
4juoC-1m6yA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER


(Rhodobacter
sphaeroides)
PF00124
(Photo_RC)
3 SER M 152
GLY L 191
GLU M 263
BPH  M   5 ( 4.1A)
None
None
0.55A 4juoA-1pssM:
0.0
4juoC-1pssM:
undetectable
4juoA-1pssM:
18.85
4juoC-1pssM:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw5 NAGD PROTEIN,
PUTATIVE


(Thermotoga
maritima)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
3 SER A  26
GLY A 230
GLU A 235
None
None
NDG  A 254 (-3.1A)
0.60A 4juoA-1pw5A:
undetectable
4juoC-1pw5A:
undetectable
4juoA-1pw5A:
20.24
4juoC-1pw5A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pww LETHAL FACTOR

(Bacillus
anthracis)
PF07737
(ATLF)
PF09156
(Anthrax-tox_M)
3 SER A 598
GLY A 657
GLU A 739
None
0.58A 4juoA-1pwwA:
undetectable
4juoC-1pwwA:
undetectable
4juoA-1pwwA:
20.69
4juoC-1pwwA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdq CATHEPSIN B

(Bos taurus)
PF00112
(Peptidase_C1)
3 SER A 220
GLY A  74
GLU A  66
None
074  A 254 (-4.3A)
None
0.51A 4juoA-1qdqA:
undetectable
4juoC-1qdqA:
undetectable
4juoA-1qdqA:
17.79
4juoC-1qdqA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE


(Streptococcus
pneumoniae)
PF00275
(EPSP_synthase)
3 SER A 353
GLY A 387
GLU A 408
None
0.61A 4juoA-1rf5A:
undetectable
4juoC-1rf5A:
undetectable
4juoA-1rf5A:
24.72
4juoC-1rf5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgf NERVE GROWTH FACTOR

(Mus musculus)
PF00089
(Trypsin)
3 SER G  26
GLY G  19
GLU G 185
None
0.41A 4juoA-1sgfG:
undetectable
4juoC-1sgfG:
undetectable
4juoA-1sgfG:
17.54
4juoC-1sgfG:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjy SUGAR TRANSPORT
PROTEIN


(Salmonella
enterica)
PF13407
(Peripla_BP_4)
3 SER A 161
GLY A  97
GLU A 122
None
0.55A 4juoA-1tjyA:
undetectable
4juoC-1tjyA:
3.2
4juoA-1tjyA:
21.04
4juoC-1tjyA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ton TONIN

(Rattus rattus)
PF00089
(Trypsin)
3 SER A  26
GLY A  19
GLU A 185
None
0.63A 4juoA-1tonA:
undetectable
4juoC-1tonA:
undetectable
4juoA-1tonA:
18.16
4juoC-1tonA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ


(Glycine max)
PF00190
(Cupin_1)
3 SER A 178
GLY A 430
GLU A 446
None
0.63A 4juoA-1uikA:
undetectable
4juoC-1uikA:
undetectable
4juoA-1uikA:
24.22
4juoC-1uikA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7w NUCLEOSIDE
DIPHOSPHATE KINASE


(Pisum sativum)
PF00334
(NDK)
3 SER A  98
GLY A 118
GLU A   4
None
0.60A 4juoA-1w7wA:
undetectable
4juoC-1w7wA:
undetectable
4juoA-1w7wA:
16.47
4juoC-1w7wA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
3 SER A 195
GLY A 218
GLU A  27
None
0.57A 4juoA-1w93A:
2.3
4juoC-1w93A:
2.0
4juoA-1w93A:
22.09
4juoC-1w93A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D


(Caenorhabditis
elegans)
PF00069
(Pkinase)
3 SER A  25
GLY A 158
GLU A 162
None
0.61A 4juoA-2bdwA:
2.6
4juoC-2bdwA:
undetectable
4juoA-2bdwA:
20.90
4juoC-2bdwA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82


(Saccharomyces
cerevisiae)
PF00183
(HSP90)
PF02518
(HATPase_c)
3 SER A 138
GLY A 100
GLU A 106
None
ATP  A1678 (-3.3A)
None
0.60A 4juoA-2cg9A:
undetectable
4juoC-2cg9A:
10.4
4juoA-2cg9A:
23.31
4juoC-2cg9A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium)
PF00232
(Glyco_hydro_1)
3 SER A  83
GLY A  51
GLU A 422
None
0.59A 4juoA-2e3zA:
undetectable
4juoC-2e3zA:
undetectable
4juoA-2e3zA:
21.44
4juoC-2e3zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium)
PF00232
(Glyco_hydro_1)
3 SER A 198
GLY A 316
GLU A 244
None
0.61A 4juoA-2e3zA:
undetectable
4juoC-2e3zA:
undetectable
4juoA-2e3zA:
21.44
4juoC-2e3zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum)
PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929)
3 SER A 451
GLY A 159
GLU A 117
None
0.53A 4juoA-2eidA:
undetectable
4juoC-2eidA:
undetectable
4juoA-2eidA:
21.86
4juoC-2eidA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE


(Sulfurisphaera
tokodaii)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
3 SER A 182
GLY A 105
GLU A  17
None
0.58A 4juoA-2f7lA:
undetectable
4juoC-2f7lA:
undetectable
4juoA-2f7lA:
22.70
4juoC-2f7lA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gbb PUTATIVE CHORISMATE
MUTASE


(Yersinia pestis)
PF01817
(CM_2)
3 SER A  80
GLY A 131
GLU A  42
None
0.61A 4juoA-2gbbA:
2.8
4juoC-2gbbA:
undetectable
4juoA-2gbbA:
16.49
4juoC-2gbbA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP


(Vibrio harveyi)
PF13407
(Peripla_BP_4)
3 SER A 363
GLY A 290
GLU A 186
None
AI2  A 501 ( 4.6A)
None
0.56A 4juoA-2hj9A:
undetectable
4juoC-2hj9A:
2.9
4juoA-2hj9A:
21.43
4juoC-2hj9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE


(Rauvolfia
serpentina)
PF00232
(Glyco_hydro_1)
3 SER A 121
GLY A  89
GLU A 472
None
0.56A 4juoA-2jf7A:
undetectable
4juoC-2jf7A:
undetectable
4juoA-2jf7A:
23.96
4juoC-2jf7A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jig PROLYL-4 HYDROXYLASE

(Chlamydomonas
reinhardtii)
PF13640
(2OG-FeII_Oxy_3)
3 SER A  90
GLY A 228
GLU A 177
None
PD2  A1254 (-3.8A)
None
0.58A 4juoA-2jigA:
undetectable
4juoC-2jigA:
undetectable
4juoA-2jigA:
16.47
4juoC-2jigA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE


(Bacillus
halodurans)
PF01019
(G_glu_transpept)
3 SER A 372
GLY A 447
GLU A 482
None
0.58A 4juoA-2nlzA:
undetectable
4juoC-2nlzA:
undetectable
4juoA-2nlzA:
22.20
4juoC-2nlzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE


(Caenorhabditis
elegans)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
3 SER A 282
GLY A  18
GLU A  49
None
0.59A 4juoA-2o3jA:
undetectable
4juoC-2o3jA:
undetectable
4juoA-2o3jA:
23.89
4juoC-2o3jA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE


(Neisseria
meningitidis)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C)
3 SER A 684
GLY A 610
GLU A 514
None
0.46A 4juoA-2olsA:
undetectable
4juoC-2olsA:
undetectable
4juoA-2olsA:
23.91
4juoC-2olsA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE


(Trypanosoma
brucei)
PF00149
(Metallophos)
3 SER A 114
GLY A  29
GLU A  35
None
0.49A 4juoA-2qjcA:
undetectable
4juoC-2qjcA:
undetectable
4juoA-2qjcA:
19.56
4juoC-2qjcA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
3 SER A 486
GLY A 201
GLU A 558
None
0.61A 4juoA-2xn1A:
undetectable
4juoC-2xn1A:
undetectable
4juoA-2xn1A:
22.37
4juoC-2xn1A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6i COLLAGENASE

(Hathewaya
histolytica)
PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N)
3 SER A 475
GLY A 373
GLU A 381
None
0.57A 4juoA-2y6iA:
4.0
4juoC-2y6iA:
undetectable
4juoA-2y6iA:
22.15
4juoC-2y6iA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4r PUTATIVE ZINC
METALLOPROTEASE
MJ0392


(Methanocaldococcus
jannaschii)
PF02163
(Peptidase_M50)
3 SER A 102
GLY A 149
GLU A 207
None
0.60A 4juoA-3b4rA:
undetectable
4juoC-3b4rA:
undetectable
4juoA-3b4rA:
19.96
4juoC-3b4rA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvp TP901-1 INTEGRASE

(Lactococcus
phage TP901-1)
PF00239
(Resolvase)
3 SER A 107
GLY A  52
GLU A  56
None
0.60A 4juoA-3bvpA:
undetectable
4juoC-3bvpA:
3.5
4juoA-3bvpA:
15.38
4juoC-3bvpA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0l GUANINE DEAMINASE

(Homo sapiens)
PF01979
(Amidohydro_1)
3 SER A 150
GLY A 213
GLU A 241
None
0.59A 4juoA-3e0lA:
undetectable
4juoC-3e0lA:
undetectable
4juoA-3e0lA:
24.30
4juoC-3e0lA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4f (+)-DELTA-CADINENE
SYNTHASE ISOZYME XC1


(Gossypium
arboreum)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
3 SER A 546
GLY A 208
GLU A 123
None
0.58A 4juoA-3g4fA:
undetectable
4juoC-3g4fA:
undetectable
4juoA-3g4fA:
24.07
4juoC-3g4fA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana)
PF13847
(Methyltransf_31)
3 SER A 271
GLY A 317
GLU A 164
None
0.52A 4juoA-3htxA:
undetectable
4juoC-3htxA:
2.6
4juoA-3htxA:
19.75
4juoC-3htxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE


(Bacillus
anthracis)
PF13561
(adh_short_C2)
3 SER A 145
GLY A 101
GLU A 105
SER  A 145 (-0.0A)
GLY  A 101 ( 0.0A)
GLU  A 105 ( 0.6A)
0.52A 4juoA-3iccA:
undetectable
4juoC-3iccA:
2.8
4juoA-3iccA:
20.69
4juoC-3iccA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252


(Thermus
thermophilus)
PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp)
3 SER A 160
GLY A 190
GLU A 404
None
0.58A 4juoA-3ie1A:
undetectable
4juoC-3ie1A:
undetectable
4juoA-3ie1A:
21.92
4juoC-3ie1A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE


(Desulfovibrio
vulgaris)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
3 SER A 312
GLY A 352
GLU A 361
None
0.61A 4juoA-3iwaA:
undetectable
4juoC-3iwaA:
undetectable
4juoA-3iwaA:
24.36
4juoC-3iwaA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE


(Cytophaga
hutchinsonii)
PF01494
(FAD_binding_3)
3 SER A  94
GLY A 344
GLU A 339
None
0.62A 4juoA-3nixA:
undetectable
4juoC-3nixA:
undetectable
4juoA-3nixA:
21.31
4juoC-3nixA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow2 50S RIBOSOMAL
PROTEIN L5P


(Haloarcula
marismortui)
PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C)
3 SER D 105
GLY D  26
GLU D  60
G  02338 ( 3.6A)
C  02346 ( 4.2A)
A  02345 ( 3.5A)
0.60A 4juoA-3ow2D:
undetectable
4juoC-3ow2D:
undetectable
4juoA-3ow2D:
17.62
4juoC-3ow2D:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4i CITRATE LYASE

(Paraburkholderia
xenovorans)
PF03328
(HpcH_HpaI)
3 SER A 307
GLY A 217
GLU A 169
None
0.60A 4juoA-3r4iA:
undetectable
4juoC-3r4iA:
undetectable
4juoA-3r4iA:
19.42
4juoC-3r4iA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE


(Anaerococcus
prevotii)
PF00215
(OMPdecase)
3 SER A 190
GLY A 146
GLU A 118
None
0.58A 4juoA-3r89A:
undetectable
4juoC-3r89A:
undetectable
4juoA-3r89A:
21.86
4juoC-3r89A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K


(Escherichia
coli)
no annotation 3 SER J 100
GLY K  34
GLU K  72
None
0.61A 4juoA-3rkoJ:
undetectable
4juoC-3rkoJ:
undetectable
4juoA-3rkoJ:
17.17
4juoC-3rkoJ:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8m ENOYL-ACP REDUCTASE

(Xanthomonas
oryzae)
PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b)
3 SER A 279
GLY A 304
GLU A  26
None
0.57A 4juoA-3s8mA:
undetectable
4juoC-3s8mA:
2.5
4juoA-3s8mA:
22.82
4juoC-3s8mA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN


(Rhodobacteraceae
bacterium KLH11)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 SER A 139
GLY A 288
GLU A 237
None
0.60A 4juoA-3sszA:
undetectable
4juoC-3sszA:
undetectable
4juoA-3sszA:
23.47
4juoC-3sszA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB


(Yersinia pestis)
PF13407
(Peripla_BP_4)
3 SER A 160
GLY A  96
GLU A 121
None
0.48A 4juoA-3t95A:
undetectable
4juoC-3t95A:
3.1
4juoA-3t95A:
22.22
4juoC-3t95A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L


(Escherichia
coli)
PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM)
3 SER A 226
GLY A 217
GLU A 175
None
0.53A 4juoA-3v8vA:
undetectable
4juoC-3v8vA:
undetectable
4juoA-3v8vA:
22.98
4juoC-3v8vA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL


([Clostridium]
cellulolyticum)
PF01261
(AP_endonuc_2)
3 SER A 240
GLY A 106
GLU A 156
None
FUD  A 301 ( 4.0A)
FUD  A 301 (-2.9A)
0.61A 4juoA-3vnkA:
undetectable
4juoC-3vnkA:
undetectable
4juoA-3vnkA:
20.97
4juoC-3vnkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE


(Ascaris suum)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF13085
(Fer2_3)
PF13534
(Fer4_17)
3 SER A 141
GLY A 362
GLU B  91
None
None
FAD  A 702 ( 4.4A)
0.62A 4juoA-3vrbA:
undetectable
4juoC-3vrbA:
undetectable
4juoA-3vrbA:
20.80
4juoC-3vrbA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1


(Candida
parapsilosis)
PF00248
(Aldo_ket_red)
3 SER A 160
GLY A  22
GLU A  65
NDP  A3001 (-3.0A)
NDP  A3001 (-3.3A)
None
0.58A 4juoA-3wg6A:
undetectable
4juoC-3wg6A:
undetectable
4juoA-3wg6A:
21.17
4juoC-3wg6A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zok 3-DEHYDROQUINATE
SYNTHASE


(Actinidia
chinensis)
PF01761
(DHQ_synthase)
3 SER A 236
GLY A 279
GLU A  87
None
None
NAD  A1381 (-3.2A)
0.57A 4juoA-3zokA:
undetectable
4juoC-3zokA:
undetectable
4juoA-3zokA:
23.18
4juoC-3zokA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1


(Homo sapiens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 SER A 338
GLY A  55
GLU A 424
None
0.57A 4juoA-4a35A:
undetectable
4juoC-4a35A:
undetectable
4juoA-4a35A:
21.48
4juoC-4a35A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica)
PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N)
3 SER A 475
GLY A 373
GLU A 381
None
0.58A 4juoA-4areA:
3.4
4juoC-4areA:
undetectable
4juoA-4areA:
22.53
4juoC-4areA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10


(Homo sapiens)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
3 SER A 449
GLY A 333
GLU A 391
None
0.46A 4juoA-4ayxA:
3.3
4juoC-4ayxA:
undetectable
4juoA-4ayxA:
22.50
4juoC-4ayxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN


(Homo sapiens)
no annotation 3 SER A 490
GLY A 263
GLU A 271
None
0.50A 4juoA-4bb9A:
undetectable
4juoC-4bb9A:
3.1
4juoA-4bb9A:
21.60
4juoC-4bb9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbw SIALIDASE
(NEURAMINIDASE)


(Bacteroides
thetaiotaomicron)
PF13088
(BNR_2)
PF14873
(BNR_assoc_N)
3 SER A 200
GLY A 271
GLU A 399
None
0.52A 4juoA-4bbwA:
undetectable
4juoC-4bbwA:
undetectable
4juoA-4bbwA:
21.55
4juoC-4bbwA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxh ELONGATION FACTOR 1A

(Oryctolagus
cuniculus)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
3 SER A 356
GLY A 408
GLU A 403
None
0.56A 4juoA-4cxhA:
undetectable
4juoC-4cxhA:
2.6
4juoA-4cxhA:
22.08
4juoC-4cxhA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzt AQUALYSIN-1

(Thermus
aquaticus)
PF00082
(Peptidase_S8)
3 SER A 206
GLY A 230
GLU A 237
None
0.61A 4juoA-4dztA:
undetectable
4juoC-4dztA:
undetectable
4juoA-4dztA:
20.32
4juoC-4dztA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
3 SER A 733
GLY A 710
GLU A 494
None
0.60A 4juoA-4f9oA:
2.7
4juoC-4f9oA:
undetectable
4juoA-4f9oA:
19.78
4juoC-4f9oA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE


(Parabacteroides
distasonis)
PF13859
(BNR_3)
PF14873
(BNR_assoc_N)
3 SER A 196
GLY A 267
GLU A 395
None
None
PO4  A 607 ( 4.8A)
0.54A 4juoA-4fj6A:
undetectable
4juoC-4fj6A:
undetectable
4juoA-4fj6A:
21.94
4juoC-4fj6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
3 SER A 469
GLY A 192
GLU A 185
None
0.54A 4juoA-4fysA:
undetectable
4juoC-4fysA:
undetectable
4juoA-4fysA:
19.45
4juoC-4fysA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3s GLUTAMINE-TRNA
LIGASE


(Saccharomyces
cerevisiae)
PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2)
3 SER A 619
GLY A 782
GLU A 556
None
GOL  A 904 ( 4.1A)
None
0.33A 4juoA-4h3sA:
undetectable
4juoC-4h3sA:
undetectable
4juoA-4h3sA:
21.40
4juoC-4h3sA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN


(Rattus
norvegicus)
no annotation 3 SER A 490
GLY A 263
GLU A 271
None
0.50A 4juoA-4lc9A:
undetectable
4juoC-4lc9A:
3.1
4juoA-4lc9A:
21.67
4juoC-4lc9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21


(Saccharomyces
cerevisiae)
PF00400
(WD40)
PF12894
(ANAPC4_WD40)
3 SER A 682
GLY A  99
GLU A 111
None
0.57A 4juoA-4nsxA:
undetectable
4juoC-4nsxA:
undetectable
4juoA-4nsxA:
21.28
4juoC-4nsxA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh1 L-IDITOL
2-DEHYDROGENASE


([Clostridium]
scindens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 SER A  43
GLY A 185
GLU A 246
None
0.61A 4juoA-4oh1A:
undetectable
4juoC-4oh1A:
2.6
4juoA-4oh1A:
22.03
4juoC-4oh1A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB


(Escherichia
coli)
PF07244
(POTRA)
PF13360
(PQQ_2)
3 SER A1329
GLY A1113
GLU A1150
None
0.56A 4juoA-4pk1A:
undetectable
4juoC-4pk1A:
undetectable
4juoA-4pk1A:
23.34
4juoC-4pk1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmd ENDO-1,4-BETA-XYLANA
SE


(Caldicellulosiruptor
bescii)
PF00331
(Glyco_hydro_10)
3 SER A  46
GLY A 213
GLU A 187
None
0.60A 4juoA-4pmdA:
undetectable
4juoC-4pmdA:
undetectable
4juoA-4pmdA:
21.72
4juoC-4pmdA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN


(Bacteroides
fragilis)
PF01368
(DHH)
3 SER A 267
GLY A 224
GLU A 247
None
0.44A 4juoA-4py9A:
1.3
4juoC-4py9A:
2.7
4juoA-4py9A:
22.11
4juoC-4py9A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN


(Bacteroides
caccae)
PF13088
(BNR_2)
PF14873
(BNR_assoc_N)
3 SER A 216
GLY A 287
GLU A 415
None
0.47A 4juoA-4q6kA:
undetectable
4juoC-4q6kA:
undetectable
4juoA-4q6kA:
21.13
4juoC-4q6kA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhb UNCHARACTERIZED
PROTEIN


(Bacteroides
vulgatus)
PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C)
3 SER A 165
GLY A 368
GLU A 294
None
0.50A 4juoA-4qhbA:
undetectable
4juoC-4qhbA:
undetectable
4juoA-4qhbA:
22.46
4juoC-4qhbA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE


(Mycobacterium
avium)
PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
3 SER A 933
GLY A 939
GLU A1010
None
0.63A 4juoA-4rcnA:
1.9
4juoC-4rcnA:
undetectable
4juoA-4rcnA:
19.09
4juoC-4rcnA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoh NUCLEOSIDE
DIPHOSPHATE KINASE


(Litopenaeus
vannamei)
PF00334
(NDK)
3 SER A  98
GLY A 118
GLU A   4
None
0.61A 4juoA-4uohA:
2.2
4juoC-4uohA:
undetectable
4juoA-4uohA:
16.09
4juoC-4uohA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE


(Geobacillus
stearothermophilus)
PF00232
(Glyco_hydro_1)
3 SER A  82
GLY A  54
GLU A 453
None
None
IMD  A 507 (-2.5A)
0.62A 4juoA-4zfmA:
undetectable
4juoC-4zfmA:
undetectable
4juoA-4zfmA:
20.85
4juoC-4zfmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bra PUTATIVE PERIPLASMIC
BINDING PROTEIN WITH
SUBSTRATE RIBOSE


(Ochrobactrum
anthropi)
PF13407
(Peripla_BP_4)
3 SER A 133
GLY A 186
GLU A 200
None
0.60A 4juoA-5braA:
undetectable
4juoC-5braA:
3.4
4juoA-5braA:
23.71
4juoC-5braA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd6 TPR-DOMAIN
CONTAINING PROTEIN


(Parabacteroides
distasonis)
PF17128
(DUF5107)
3 SER A 486
GLY A  44
GLU A  63
None
0.59A 4juoA-5cd6A:
undetectable
4juoC-5cd6A:
undetectable
4juoA-5cd6A:
20.80
4juoC-5cd6A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus)
no annotation 3 SER B 569
GLY B 669
GLU B 715
None
0.59A 4juoA-5dlqB:
undetectable
4juoC-5dlqB:
undetectable
4juoA-5dlqB:
18.60
4juoC-5dlqB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eix DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A


(Klebsiella
pneumoniae)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
3 SER A 422
GLY A1078
GLU A1084
None
None
MG  A1502 ( 4.3A)
0.50A 4juoA-5eixA:
45.4
4juoC-5eixA:
24.5
4juoA-5eixA:
29.96
4juoC-5eixA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE


(Plasmodium
falciparum)
PF00227
(Proteasome)
3 SER K  24
GLY L  47
GLU L  56
None
0.62A 4juoA-5fmgK:
undetectable
4juoC-5fmgK:
undetectable
4juoA-5fmgK:
18.24
4juoC-5fmgK:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT


(Escherichia
coli)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
3 SER C 235
GLY C 244
GLU C 345
None
0.62A 4juoA-5g5gC:
undetectable
4juoC-5g5gC:
undetectable
4juoA-5g5gC:
21.20
4juoC-5g5gC:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE


(Medicago
truncatula)
PF00795
(CN_hydrolase)
3 SER A 192
GLY A 129
GLU A 132
None
0.62A 4juoA-5h8kA:
undetectable
4juoC-5h8kA:
undetectable
4juoA-5h8kA:
20.59
4juoC-5h8kA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1


(Staphylococcus
aureus)
no annotation 3 SER B 196
GLY B  82
GLU B 282
None
0.42A 4juoA-5k59B:
undetectable
4juoC-5k59B:
undetectable
4juoA-5k59B:
21.13
4juoC-5k59B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43


(Chaetomium
thermophilum)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind)
3 SER A 158
GLY A 349
GLU A 320
None
U  E   5 ( 3.7A)
None
0.62A 4juoA-5ltaA:
3.5
4juoC-5ltaA:
2.2
4juoA-5ltaA:
22.49
4juoC-5ltaA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mh5 D-2-HYDROXYACID
DEHYDROGENASE


(Haloferax
mediterranei)
no annotation 3 SER A 261
GLY A 227
GLU A  71
None
0.62A 4juoA-5mh5A:
undetectable
4juoC-5mh5A:
undetectable
4juoA-5mh5A:
12.50
4juoC-5mh5A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mog PHYTOENE
DEHYDROGENASE,
CHLOROPLASTIC/CHROMO
PLASTIC


(Oryza sativa)
PF01593
(Amino_oxidase)
3 SER A 547
GLY A 141
GLU A 155
None
FAD  A 600 (-3.2A)
None
0.61A 4juoA-5mogA:
undetectable
4juoC-5mogA:
undetectable
4juoA-5mogA:
23.64
4juoC-5mogA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nc8 POTASSIUM EFFLUX
SYSTEM PROTEIN


(Shewanella
denitrificans)
PF02254
(TrkA_N)
3 SER A 440
GLY A 418
GLU A 524
None
0.58A 4juoA-5nc8A:
undetectable
4juoC-5nc8A:
undetectable
4juoA-5nc8A:
20.67
4juoC-5nc8A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron)
no annotation 3 SER D 581
GLY D 549
GLU D 481
None
0.52A 4juoA-5t4yD:
undetectable
4juoC-5t4yD:
undetectable
4juoA-5t4yD:
19.14
4juoC-5t4yD:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6u CYTOCHROME P450

(Rhodopseudomonas
palustris)
no annotation 3 SER A  95
GLY A 360
GLU A 367
81M  A 502 (-2.5A)
HEM  A 501 (-3.6A)
None
0.56A 4juoA-5u6uA:
undetectable
4juoC-5u6uA:
undetectable
4juoA-5u6uA:
11.42
4juoC-5u6uA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL


(Homo sapiens)
no annotation 3 SER A 417
GLY A 175
GLU A 191
None
0.62A 4juoA-5v7iA:
2.0
4juoC-5v7iA:
undetectable
4juoA-5v7iA:
23.36
4juoC-5v7iA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A


(Homo sapiens)
PF00628
(PHD)
PF01388
(ARID)
PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2)
PF08429
(PLU-1)
3 SER A 420
GLY A 442
GLU A 452
None
0.60A 4juoA-5v9pA:
2.3
4juoC-5v9pA:
undetectable
4juoA-5v9pA:
20.10
4juoC-5v9pA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC


(Medicago
truncatula)
PF00815
(Histidinol_dh)
3 SER A 426
GLY A 387
GLU A 384
None
0.57A 4juoA-5vldA:
undetectable
4juoC-5vldA:
undetectable
4juoA-5vldA:
24.43
4juoC-5vldA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2


(Homo sapiens)
no annotation 3 SER g  40
GLY g  71
GLU g  78
None
0.56A 4juoA-5xtcg:
undetectable
4juoC-5xtcg:
undetectable
4juoA-5xtcg:
12.90
4juoC-5xtcg:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN


(SFTS
phlebovirus)
PF07243
(Phlebovirus_G1)
3 SER C  45
GLY C 282
GLU C 293
None
0.59A 4juoA-5y10C:
undetectable
4juoC-5y10C:
undetectable
4juoA-5y10C:
20.52
4juoC-5y10C:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3x BETA-XYLANASE

(Caldicellulosiruptor
owensensis)
no annotation 3 SER A  45
GLY A 213
GLU A 187
None
0.62A 4juoA-5y3xA:
undetectable
4juoC-5y3xA:
undetectable
4juoA-5y3xA:
10.89
4juoC-5y3xA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brs PUTATIVE ZINC
PROTEASE


(Pectobacterium
atrosepticum)
no annotation 3 SER A 296
GLY A 425
GLU A 397
None
0.62A 4juoA-6brsA:
1.3
4juoC-6brsA:
2.2
4juoA-6brsA:
10.47
4juoC-6brsA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8


(Homo sapiens)
no annotation 3 SER A 308
GLY A 225
GLU A 256
None
0.57A 4juoA-6bszA:
undetectable
4juoC-6bszA:
3.5
4juoA-6bszA:
10.16
4juoC-6bszA:
8.75