SIMILAR PATTERNS OF AMINO ACIDS FOR 4JUO_F_LFXF101
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1be4 | NUCLEOSIDEDIPHOSPHATETRANSFERASE (Bos taurus) |
PF00334(NDK) | 3 | SER A 99GLY A 119GLU A 5 | None | 0.62A | 4juoA-1be4A:undetectable4juoC-1be4A:undetectable | 4juoA-1be4A:16.944juoC-1be4A:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dqs | PROTEIN(3-DEHYDROQUINATESYNTHASE) (Aspergillusnidulans) |
PF01761(DHQ_synthase) | 3 | SER A 246GLY A 288GLU A 81 | NoneNoneNAD A 400 (-2.8A) | 0.47A | 4juoA-1dqsA:0.04juoC-1dqsA:3.5 | 4juoA-1dqsA:25.834juoC-1dqsA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1foh | PHENOL HYDROXYLASE (Cutaneotrichosporoncutaneum) |
PF01494(FAD_binding_3)PF07976(Phe_hydrox_dim) | 3 | SER A 419GLY A 241GLU A 344 | None | 0.50A | 4juoA-1fohA:undetectable4juoC-1fohA:undetectable | 4juoA-1fohA:22.654juoC-1fohA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i9z | PHOSPHATIDYLINOSITOLPHOSPHATEPHOSPHATASE (Schizosaccharomycespombe) |
PF03372(Exo_endo_phos) | 3 | SER A 837GLY A 739GLU A 785 | None | 0.61A | 4juoA-1i9zA:0.04juoC-1i9zA:undetectable | 4juoA-1i9zA:19.614juoC-1i9zA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jr7 | HYPOTHETICAL 37.4KDA PROTEIN INILEY-GABD INTERGENICREGION (Escherichiacoli) |
PF08943(CsiD) | 3 | SER A 26GLY A 271GLU A 267 | None | 0.62A | 4juoA-1jr7A:0.04juoC-1jr7A:undetectable | 4juoA-1jr7A:18.814juoC-1jr7A:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k3r | CONSERVED PROTEINMT0001 (Methanothermobacterthermautotrophicus) |
PF02598(Methyltrn_RNA_3) | 3 | SER A 177GLY A 52GLU A 17 | None | 0.60A | 4juoA-1k3rA:0.04juoC-1k3rA:undetectable | 4juoA-1k3rA:24.474juoC-1k3rA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ktw | IOTA-CARRAGEENASE (Alteromonas sp.ATCC 43554) |
PF12708(Pectate_lyase_3) | 3 | SER A 300GLY A 279GLU A 310 | None | 0.49A | 4juoA-1ktwA:0.04juoC-1ktwA:undetectable | 4juoA-1ktwA:21.564juoC-1ktwA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m6y | S-ADENOSYL-METHYLTRANSFERASE MRAW (Thermotogamaritima) |
PF01795(Methyltransf_5) | 3 | SER A 5GLY A 37GLU A 70 | NoneSAH A 401 (-3.3A)None | 0.59A | 4juoA-1m6yA:undetectable4juoC-1m6yA:undetectable | 4juoA-1m6yA:19.584juoC-1m6yA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pss | PHOTOSYNTHETICREACTION CENTER (Rhodobactersphaeroides) |
PF00124(Photo_RC) | 3 | SER M 152GLY L 191GLU M 263 | BPH M 5 ( 4.1A)NoneNone | 0.55A | 4juoA-1pssM:0.04juoC-1pssM:undetectable | 4juoA-1pssM:18.854juoC-1pssM:18.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pw5 | NAGD PROTEIN,PUTATIVE (Thermotogamaritima) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 3 | SER A 26GLY A 230GLU A 235 | NoneNoneNDG A 254 (-3.1A) | 0.60A | 4juoA-1pw5A:undetectable4juoC-1pw5A:undetectable | 4juoA-1pw5A:20.244juoC-1pw5A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pww | LETHAL FACTOR (Bacillusanthracis) |
PF07737(ATLF)PF09156(Anthrax-tox_M) | 3 | SER A 598GLY A 657GLU A 739 | None | 0.58A | 4juoA-1pwwA:undetectable4juoC-1pwwA:undetectable | 4juoA-1pwwA:20.694juoC-1pwwA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qdq | CATHEPSIN B (Bos taurus) |
PF00112(Peptidase_C1) | 3 | SER A 220GLY A 74GLU A 66 | None074 A 254 (-4.3A)None | 0.51A | 4juoA-1qdqA:undetectable4juoC-1qdqA:undetectable | 4juoA-1qdqA:17.794juoC-1qdqA:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rf5 | 5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATESYNTHASE (Streptococcuspneumoniae) |
PF00275(EPSP_synthase) | 3 | SER A 353GLY A 387GLU A 408 | None | 0.61A | 4juoA-1rf5A:undetectable4juoC-1rf5A:undetectable | 4juoA-1rf5A:24.724juoC-1rf5A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sgf | NERVE GROWTH FACTOR (Mus musculus) |
PF00089(Trypsin) | 3 | SER G 26GLY G 19GLU G 185 | None | 0.41A | 4juoA-1sgfG:undetectable4juoC-1sgfG:undetectable | 4juoA-1sgfG:17.544juoC-1sgfG:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tjy | SUGAR TRANSPORTPROTEIN (Salmonellaenterica) |
PF13407(Peripla_BP_4) | 3 | SER A 161GLY A 97GLU A 122 | None | 0.55A | 4juoA-1tjyA:undetectable4juoC-1tjyA:3.2 | 4juoA-1tjyA:21.044juoC-1tjyA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ton | TONIN (Rattus rattus) |
PF00089(Trypsin) | 3 | SER A 26GLY A 19GLU A 185 | None | 0.63A | 4juoA-1tonA:undetectable4juoC-1tonA:undetectable | 4juoA-1tonA:18.164juoC-1tonA:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uik | ALPHA PRIME SUBUNITOF BETA-CONGLYCININ (Glycine max) |
PF00190(Cupin_1) | 3 | SER A 178GLY A 430GLU A 446 | None | 0.63A | 4juoA-1uikA:undetectable4juoC-1uikA:undetectable | 4juoA-1uikA:24.224juoC-1uikA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w7w | NUCLEOSIDEDIPHOSPHATE KINASE (Pisum sativum) |
PF00334(NDK) | 3 | SER A 98GLY A 118GLU A 4 | None | 0.60A | 4juoA-1w7wA:undetectable4juoC-1w7wA:undetectable | 4juoA-1w7wA:16.474juoC-1w7wA:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w93 | ACETYL-COENZYME ACARBOXYLASE (Saccharomycescerevisiae) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 3 | SER A 195GLY A 218GLU A 27 | None | 0.57A | 4juoA-1w93A:2.34juoC-1w93A:2.0 | 4juoA-1w93A:22.094juoC-1w93A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bdw | HYPOTHETICAL PROTEINK11E8.1D (Caenorhabditiselegans) |
PF00069(Pkinase) | 3 | SER A 25GLY A 158GLU A 162 | None | 0.61A | 4juoA-2bdwA:2.64juoC-2bdwA:undetectable | 4juoA-2bdwA:20.904juoC-2bdwA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cg9 | ATP-DEPENDENTMOLECULAR CHAPERONEHSP82 (Saccharomycescerevisiae) |
PF00183(HSP90)PF02518(HATPase_c) | 3 | SER A 138GLY A 100GLU A 106 | NoneATP A1678 (-3.3A)None | 0.60A | 4juoA-2cg9A:undetectable4juoC-2cg9A:10.4 | 4juoA-2cg9A:23.314juoC-2cg9A:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e3z | BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF00232(Glyco_hydro_1) | 3 | SER A 83GLY A 51GLU A 422 | None | 0.59A | 4juoA-2e3zA:undetectable4juoC-2e3zA:undetectable | 4juoA-2e3zA:21.444juoC-2e3zA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e3z | BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF00232(Glyco_hydro_1) | 3 | SER A 198GLY A 316GLU A 244 | None | 0.61A | 4juoA-2e3zA:undetectable4juoC-2e3zA:undetectable | 4juoA-2e3zA:21.444juoC-2e3zA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eid | GALACTOSE OXIDASE (Fusariumgraminearum) |
PF00754(F5_F8_type_C)PF01344(Kelch_1)PF09118(DUF1929) | 3 | SER A 451GLY A 159GLU A 117 | None | 0.53A | 4juoA-2eidA:undetectable4juoC-2eidA:undetectable | 4juoA-2eidA:21.864juoC-2eidA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f7l | 455AA LONGHYPOTHETICALPHOSPHO-SUGAR MUTASE (Sulfurisphaeratokodaii) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 3 | SER A 182GLY A 105GLU A 17 | None | 0.58A | 4juoA-2f7lA:undetectable4juoC-2f7lA:undetectable | 4juoA-2f7lA:22.704juoC-2f7lA:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gbb | PUTATIVE CHORISMATEMUTASE (Yersinia pestis) |
PF01817(CM_2) | 3 | SER A 80GLY A 131GLU A 42 | None | 0.61A | 4juoA-2gbbA:2.84juoC-2gbbA:undetectable | 4juoA-2gbbA:16.494juoC-2gbbA:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hj9 | AUTOINDUCER2-BINDINGPERIPLASMIC PROTEINLUXP (Vibrio harveyi) |
PF13407(Peripla_BP_4) | 3 | SER A 363GLY A 290GLU A 186 | NoneAI2 A 501 ( 4.6A)None | 0.56A | 4juoA-2hj9A:undetectable4juoC-2hj9A:2.9 | 4juoA-2hj9A:21.434juoC-2hj9A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jf7 | STRICTOSIDINE-O-BETA-D-GLUCOSIDASE (Rauvolfiaserpentina) |
PF00232(Glyco_hydro_1) | 3 | SER A 121GLY A 89GLU A 472 | None | 0.56A | 4juoA-2jf7A:undetectable4juoC-2jf7A:undetectable | 4juoA-2jf7A:23.964juoC-2jf7A:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jig | PROLYL-4 HYDROXYLASE (Chlamydomonasreinhardtii) |
PF13640(2OG-FeII_Oxy_3) | 3 | SER A 90GLY A 228GLU A 177 | NonePD2 A1254 (-3.8A)None | 0.58A | 4juoA-2jigA:undetectable4juoC-2jigA:undetectable | 4juoA-2jigA:16.474juoC-2jigA:15.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nlz | CEPHALOSPORINACYLASE (Bacillushalodurans) |
PF01019(G_glu_transpept) | 3 | SER A 372GLY A 447GLU A 482 | None | 0.58A | 4juoA-2nlzA:undetectable4juoC-2nlzA:undetectable | 4juoA-2nlzA:22.204juoC-2nlzA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3j | UDP-GLUCOSE6-DEHYDROGENASE (Caenorhabditiselegans) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 3 | SER A 282GLY A 18GLU A 49 | None | 0.59A | 4juoA-2o3jA:undetectable4juoC-2o3jA:undetectable | 4juoA-2o3jA:23.894juoC-2o3jA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ols | PHOSPHOENOLPYRUVATESYNTHASE (Neisseriameningitidis) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 3 | SER A 684GLY A 610GLU A 514 | None | 0.46A | 4juoA-2olsA:undetectable4juoC-2olsA:undetectable | 4juoA-2olsA:23.914juoC-2olsA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qjc | DIADENOSINETETRAPHOSPHATASE,PUTATIVE (Trypanosomabrucei) |
PF00149(Metallophos) | 3 | SER A 114GLY A 29GLU A 35 | None | 0.49A | 4juoA-2qjcA:undetectable4juoC-2qjcA:undetectable | 4juoA-2qjcA:19.564juoC-2qjcA:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xn1 | ALPHA-GALACTOSIDASE (Lactobacillusacidophilus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 3 | SER A 486GLY A 201GLU A 558 | None | 0.61A | 4juoA-2xn1A:undetectable4juoC-2xn1A:undetectable | 4juoA-2xn1A:22.374juoC-2xn1A:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y6i | COLLAGENASE (Hathewayahistolytica) |
PF01752(Peptidase_M9)PF08453(Peptidase_M9_N) | 3 | SER A 475GLY A 373GLU A 381 | None | 0.57A | 4juoA-2y6iA:4.04juoC-2y6iA:undetectable | 4juoA-2y6iA:22.154juoC-2y6iA:25.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b4r | PUTATIVE ZINCMETALLOPROTEASEMJ0392 (Methanocaldococcusjannaschii) |
PF02163(Peptidase_M50) | 3 | SER A 102GLY A 149GLU A 207 | None | 0.60A | 4juoA-3b4rA:undetectable4juoC-3b4rA:undetectable | 4juoA-3b4rA:19.964juoC-3b4rA:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bvp | TP901-1 INTEGRASE (Lactococcusphage TP901-1) |
PF00239(Resolvase) | 3 | SER A 107GLY A 52GLU A 56 | None | 0.60A | 4juoA-3bvpA:undetectable4juoC-3bvpA:3.5 | 4juoA-3bvpA:15.384juoC-3bvpA:11.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e0l | GUANINE DEAMINASE (Homo sapiens) |
PF01979(Amidohydro_1) | 3 | SER A 150GLY A 213GLU A 241 | None | 0.59A | 4juoA-3e0lA:undetectable4juoC-3e0lA:undetectable | 4juoA-3e0lA:24.304juoC-3e0lA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g4f | (+)-DELTA-CADINENESYNTHASE ISOZYME XC1 (Gossypiumarboreum) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 3 | SER A 546GLY A 208GLU A 123 | None | 0.58A | 4juoA-3g4fA:undetectable4juoC-3g4fA:undetectable | 4juoA-3g4fA:24.074juoC-3g4fA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3htx | HEN1 (Arabidopsisthaliana) |
PF13847(Methyltransf_31) | 3 | SER A 271GLY A 317GLU A 164 | None | 0.52A | 4juoA-3htxA:undetectable4juoC-3htxA:2.6 | 4juoA-3htxA:19.754juoC-3htxA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icc | PUTATIVE3-OXOACYL-(ACYLCARRIER PROTEIN)REDUCTASE (Bacillusanthracis) |
PF13561(adh_short_C2) | 3 | SER A 145GLY A 101GLU A 105 | SER A 145 (-0.0A)GLY A 101 ( 0.0A)GLU A 105 ( 0.6A) | 0.52A | 4juoA-3iccA:undetectable4juoC-3iccA:2.8 | 4juoA-3iccA:20.694juoC-3iccA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ie1 | RIBONUCLEASETTHA0252 (Thermusthermophilus) |
PF00753(Lactamase_B)PF07521(RMMBL)PF10996(Beta-Casp) | 3 | SER A 160GLY A 190GLU A 404 | None | 0.58A | 4juoA-3ie1A:undetectable4juoC-3ie1A:undetectable | 4juoA-3ie1A:21.924juoC-3ie1A:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwa | FAD-DEPENDENTPYRIDINENUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE (Desulfovibriovulgaris) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 3 | SER A 312GLY A 352GLU A 361 | None | 0.61A | 4juoA-3iwaA:undetectable4juoC-3iwaA:undetectable | 4juoA-3iwaA:24.364juoC-3iwaA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nix | FLAVOPROTEIN/DEHYDROGENASE (Cytophagahutchinsonii) |
PF01494(FAD_binding_3) | 3 | SER A 94GLY A 344GLU A 339 | None | 0.62A | 4juoA-3nixA:undetectable4juoC-3nixA:undetectable | 4juoA-3nixA:21.314juoC-3nixA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ow2 | 50S RIBOSOMALPROTEIN L5P (Haloarculamarismortui) |
PF00281(Ribosomal_L5)PF00673(Ribosomal_L5_C) | 3 | SER D 105GLY D 26GLU D 60 | G 02338 ( 3.6A) C 02346 ( 4.2A) A 02345 ( 3.5A) | 0.60A | 4juoA-3ow2D:undetectable4juoC-3ow2D:undetectable | 4juoA-3ow2D:17.624juoC-3ow2D:15.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r4i | CITRATE LYASE (Paraburkholderiaxenovorans) |
PF03328(HpcH_HpaI) | 3 | SER A 307GLY A 217GLU A 169 | None | 0.60A | 4juoA-3r4iA:undetectable4juoC-3r4iA:undetectable | 4juoA-3r4iA:19.424juoC-3r4iA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r89 | OROTIDINE5'-PHOSPHATEDECARBOXYLASE (Anaerococcusprevotii) |
PF00215(OMPdecase) | 3 | SER A 190GLY A 146GLU A 118 | None | 0.58A | 4juoA-3r89A:undetectable4juoC-3r89A:undetectable | 4juoA-3r89A:21.864juoC-3r89A:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT JNADH-QUINONEOXIDOREDUCTASESUBUNIT K (Escherichiacoli) |
no annotation | 3 | SER J 100GLY K 34GLU K 72 | None | 0.61A | 4juoA-3rkoJ:undetectable4juoC-3rkoJ:undetectable | 4juoA-3rkoJ:17.174juoC-3rkoJ:14.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s8m | ENOYL-ACP REDUCTASE (Xanthomonasoryzae) |
PF07055(Eno-Rase_FAD_bd)PF12241(Enoyl_reductase)PF12242(Eno-Rase_NADH_b) | 3 | SER A 279GLY A 304GLU A 26 | None | 0.57A | 4juoA-3s8mA:undetectable4juoC-3s8mA:2.5 | 4juoA-3s8mA:22.824juoC-3s8mA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ssz | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME,N-TERMINAL DOMAINPROTEIN (Rhodobacteraceaebacterium KLH11) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | SER A 139GLY A 288GLU A 237 | None | 0.60A | 4juoA-3sszA:undetectable4juoC-3sszA:undetectable | 4juoA-3sszA:23.474juoC-3sszA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t95 | AUTOINDUCER2-BINDING PROTEINLSRB (Yersinia pestis) |
PF13407(Peripla_BP_4) | 3 | SER A 160GLY A 96GLU A 121 | None | 0.48A | 4juoA-3t95A:undetectable4juoC-3t95A:3.1 | 4juoA-3t95A:22.224juoC-3t95A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v8v | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE L (Escherichiacoli) |
PF01170(UPF0020)PF02926(THUMP)PF10672(Methyltrans_SAM) | 3 | SER A 226GLY A 217GLU A 175 | None | 0.53A | 4juoA-3v8vA:undetectable4juoC-3v8vA:undetectable | 4juoA-3v8vA:22.984juoC-3v8vA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vnk | XYLOSE ISOMERASEDOMAIN PROTEIN TIMBARREL ([Clostridium]cellulolyticum) |
PF01261(AP_endonuc_2) | 3 | SER A 240GLY A 106GLU A 156 | NoneFUD A 301 ( 4.0A)FUD A 301 (-2.9A) | 0.61A | 4juoA-3vnkA:undetectable4juoC-3vnkA:undetectable | 4juoA-3vnkA:20.974juoC-3vnkA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrb | FLAVOPROTEIN SUBUNITOF COMPLEX IIIRON-SULFUR SUBUNITOF SUCCINATEDEHYDROGENASE (Ascaris suum) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C)PF13085(Fer2_3)PF13534(Fer4_17) | 3 | SER A 141GLY A 362GLU B 91 | NoneNoneFAD A 702 ( 4.4A) | 0.62A | 4juoA-3vrbA:undetectable4juoC-3vrbA:undetectable | 4juoA-3vrbA:20.804juoC-3vrbA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wg6 | CONJUGATEDPOLYKETONE REDUCTASEC1 (Candidaparapsilosis) |
PF00248(Aldo_ket_red) | 3 | SER A 160GLY A 22GLU A 65 | NDP A3001 (-3.0A)NDP A3001 (-3.3A)None | 0.58A | 4juoA-3wg6A:undetectable4juoC-3wg6A:undetectable | 4juoA-3wg6A:21.174juoC-3wg6A:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zok | 3-DEHYDROQUINATESYNTHASE (Actinidiachinensis) |
PF01761(DHQ_synthase) | 3 | SER A 236GLY A 279GLU A 87 | NoneNoneNAD A1381 (-3.2A) | 0.57A | 4juoA-3zokA:undetectable4juoC-3zokA:undetectable | 4juoA-3zokA:23.184juoC-3zokA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a35 | MITOCHONDRIALENOLASE SUPERFAMILYMEMBER 1 (Homo sapiens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | SER A 338GLY A 55GLU A 424 | None | 0.57A | 4juoA-4a35A:undetectable4juoC-4a35A:undetectable | 4juoA-4a35A:21.484juoC-4a35A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4are | COLLAGENASE G (Hathewayahistolytica) |
PF01752(Peptidase_M9)PF08453(Peptidase_M9_N) | 3 | SER A 475GLY A 373GLU A 381 | None | 0.58A | 4juoA-4areA:3.44juoC-4areA:undetectable | 4juoA-4areA:22.534juoC-4areA:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ayx | ATP-BINDING CASSETTESUB-FAMILY B MEMBER10 (Homo sapiens) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 3 | SER A 449GLY A 333GLU A 391 | None | 0.46A | 4juoA-4ayxA:3.34juoC-4ayxA:undetectable | 4juoA-4ayxA:22.504juoC-4ayxA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bb9 | GLUCOKINASEREGULATORY PROTEIN (Homo sapiens) |
no annotation | 3 | SER A 490GLY A 263GLU A 271 | None | 0.50A | 4juoA-4bb9A:undetectable4juoC-4bb9A:3.1 | 4juoA-4bb9A:21.604juoC-4bb9A:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bbw | SIALIDASE(NEURAMINIDASE) (Bacteroidesthetaiotaomicron) |
PF13088(BNR_2)PF14873(BNR_assoc_N) | 3 | SER A 200GLY A 271GLU A 399 | None | 0.52A | 4juoA-4bbwA:undetectable4juoC-4bbwA:undetectable | 4juoA-4bbwA:21.554juoC-4bbwA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cxh | ELONGATION FACTOR 1A (Oryctolaguscuniculus) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 3 | SER A 356GLY A 408GLU A 403 | None | 0.56A | 4juoA-4cxhA:undetectable4juoC-4cxhA:2.6 | 4juoA-4cxhA:22.084juoC-4cxhA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dzt | AQUALYSIN-1 (Thermusaquaticus) |
PF00082(Peptidase_S8) | 3 | SER A 206GLY A 230GLU A 237 | None | 0.61A | 4juoA-4dztA:undetectable4juoC-4dztA:undetectable | 4juoA-4dztA:20.324juoC-4dztA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f9o | HEXOKINASE-1 (Homo sapiens) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 3 | SER A 733GLY A 710GLU A 494 | None | 0.60A | 4juoA-4f9oA:2.74juoC-4f9oA:undetectable | 4juoA-4f9oA:19.784juoC-4f9oA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fj6 | GLYCOSIDE HYDROLASEFAMILY 33, CANDIDATESIALIDASE (Parabacteroidesdistasonis) |
PF13859(BNR_3)PF14873(BNR_assoc_N) | 3 | SER A 196GLY A 267GLU A 395 | NoneNonePO4 A 607 ( 4.8A) | 0.54A | 4juoA-4fj6A:undetectable4juoC-4fj6A:undetectable | 4juoA-4fj6A:21.944juoC-4fj6A:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fys | AMINOPEPTIDASE N (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 3 | SER A 469GLY A 192GLU A 185 | None | 0.54A | 4juoA-4fysA:undetectable4juoC-4fysA:undetectable | 4juoA-4fysA:19.454juoC-4fysA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h3s | GLUTAMINE-TRNALIGASE (Saccharomycescerevisiae) |
PF00749(tRNA-synt_1c)PF03950(tRNA-synt_1c_C)PF04557(tRNA_synt_1c_R2) | 3 | SER A 619GLY A 782GLU A 556 | NoneGOL A 904 ( 4.1A)None | 0.33A | 4juoA-4h3sA:undetectable4juoC-4h3sA:undetectable | 4juoA-4h3sA:21.404juoC-4h3sA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lc9 | GLUCOKINASEREGULATORY PROTEIN (Rattusnorvegicus) |
no annotation | 3 | SER A 490GLY A 263GLU A 271 | None | 0.50A | 4juoA-4lc9A:undetectable4juoC-4lc9A:3.1 | 4juoA-4lc9A:21.674juoC-4lc9A:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nsx | U3 SMALL NUCLEOLARRNA-ASSOCIATEDPROTEIN 21 (Saccharomycescerevisiae) |
PF00400(WD40)PF12894(ANAPC4_WD40) | 3 | SER A 682GLY A 99GLU A 111 | None | 0.57A | 4juoA-4nsxA:undetectable4juoC-4nsxA:undetectable | 4juoA-4nsxA:21.284juoC-4nsxA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oh1 | L-IDITOL2-DEHYDROGENASE ([Clostridium]scindens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | SER A 43GLY A 185GLU A 246 | None | 0.61A | 4juoA-4oh1A:undetectable4juoC-4oh1A:2.6 | 4juoA-4oh1A:22.034juoC-4oh1A:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pk1 | CHIMERA PROTEIN OFOUTER MEMBRANEPROTEIN ASSEMBLYFACTORS BAMA ANDBAMB (Escherichiacoli) |
PF07244(POTRA)PF13360(PQQ_2) | 3 | SER A1329GLY A1113GLU A1150 | None | 0.56A | 4juoA-4pk1A:undetectable4juoC-4pk1A:undetectable | 4juoA-4pk1A:23.344juoC-4pk1A:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pmd | ENDO-1,4-BETA-XYLANASE (Caldicellulosiruptorbescii) |
PF00331(Glyco_hydro_10) | 3 | SER A 46GLY A 213GLU A 187 | None | 0.60A | 4juoA-4pmdA:undetectable4juoC-4pmdA:undetectable | 4juoA-4pmdA:21.724juoC-4pmdA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4py9 | PUTATIVEEXOPOLYPHOSPHATASE-RELATED PROTEIN (Bacteroidesfragilis) |
PF01368(DHH) | 3 | SER A 267GLY A 224GLU A 247 | None | 0.44A | 4juoA-4py9A:1.34juoC-4py9A:2.7 | 4juoA-4py9A:22.114juoC-4py9A:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6k | BNR/ASP-BOX REPEATPROTEIN (Bacteroidescaccae) |
PF13088(BNR_2)PF14873(BNR_assoc_N) | 3 | SER A 216GLY A 287GLU A 415 | None | 0.47A | 4juoA-4q6kA:undetectable4juoC-4q6kA:undetectable | 4juoA-4q6kA:21.134juoC-4q6kA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qhb | UNCHARACTERIZEDPROTEIN (Bacteroidesvulgatus) |
PF09112(N-glycanase_N)PF09113(N-glycanase_C) | 3 | SER A 165GLY A 368GLU A 294 | None | 0.50A | 4juoA-4qhbA:undetectable4juoC-4qhbA:undetectable | 4juoA-4qhbA:22.464juoC-4qhbA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rcn | LONG-CHAIN ACYL-COACARBOXYLASE (Mycobacteriumavium) |
PF00289(Biotin_carb_N)PF01039(Carboxyl_trans)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 3 | SER A 933GLY A 939GLU A1010 | None | 0.63A | 4juoA-4rcnA:1.94juoC-4rcnA:undetectable | 4juoA-4rcnA:19.094juoC-4rcnA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoh | NUCLEOSIDEDIPHOSPHATE KINASE (Litopenaeusvannamei) |
PF00334(NDK) | 3 | SER A 98GLY A 118GLU A 4 | None | 0.61A | 4juoA-4uohA:2.24juoC-4uohA:undetectable | 4juoA-4uohA:16.094juoC-4uohA:13.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zfm | PUTATIVE6-PHOSPHO-BETA-GALACTOBIOSIDASE (Geobacillusstearothermophilus) |
PF00232(Glyco_hydro_1) | 3 | SER A 82GLY A 54GLU A 453 | NoneNoneIMD A 507 (-2.5A) | 0.62A | 4juoA-4zfmA:undetectable4juoC-4zfmA:undetectable | 4juoA-4zfmA:20.854juoC-4zfmA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bra | PUTATIVE PERIPLASMICBINDING PROTEIN WITHSUBSTRATE RIBOSE (Ochrobactrumanthropi) |
PF13407(Peripla_BP_4) | 3 | SER A 133GLY A 186GLU A 200 | None | 0.60A | 4juoA-5braA:undetectable4juoC-5braA:3.4 | 4juoA-5braA:23.714juoC-5braA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cd6 | TPR-DOMAINCONTAINING PROTEIN (Parabacteroidesdistasonis) |
PF17128(DUF5107) | 3 | SER A 486GLY A 44GLU A 63 | None | 0.59A | 4juoA-5cd6A:undetectable4juoC-5cd6A:undetectable | 4juoA-5cd6A:20.804juoC-5cd6A:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dlq | EXPORTIN-4 (Mus musculus) |
no annotation | 3 | SER B 569GLY B 669GLU B 715 | None | 0.59A | 4juoA-5dlqB:undetectable4juoC-5dlqB:undetectable | 4juoA-5dlqB:18.604juoC-5dlqB:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eix | DNA TOPOISOMERASE 4SUBUNIT B,DNATOPOISOMERASE 4SUBUNIT A (Klebsiellapneumoniae) |
PF00521(DNA_topoisoIV)PF00986(DNA_gyraseB_C)PF01751(Toprim) | 3 | SER A 422GLY A1078GLU A1084 | NoneNone MG A1502 ( 4.3A) | 0.50A | 4juoA-5eixA:45.44juoC-5eixA:24.5 | 4juoA-5eixA:29.964juoC-5eixA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME SUBUNITBETA TYPE (Plasmodiumfalciparum) |
PF00227(Proteasome) | 3 | SER K 24GLY L 47GLU L 56 | None | 0.62A | 4juoA-5fmgK:undetectable4juoC-5fmgK:undetectable | 4juoA-5fmgK:18.244juoC-5fmgK:15.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5g | PUTATIVE XANTHINEDEHYDROGENASE YAGSFAD-BINDING SUBUNIT (Escherichiacoli) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 3 | SER C 235GLY C 244GLU C 345 | None | 0.62A | 4juoA-5g5gC:undetectable4juoC-5g5gC:undetectable | 4juoA-5g5gC:21.204juoC-5g5gC:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h8k | N-CARBAMOYLPUTRESCINE AMIDOHYDROLASE (Medicagotruncatula) |
PF00795(CN_hydrolase) | 3 | SER A 192GLY A 129GLU A 132 | None | 0.62A | 4juoA-5h8kA:undetectable4juoC-5h8kA:undetectable | 4juoA-5h8kA:20.594juoC-5h8kA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k59 | UNCHARACTERIZEDLEUKOCIDIN-LIKEPROTEIN 1 (Staphylococcusaureus) |
no annotation | 3 | SER B 196GLY B 82GLU B 282 | None | 0.42A | 4juoA-5k59B:undetectable4juoC-5k59B:undetectable | 4juoA-5k59B:21.134juoC-5k59B:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lta | PRE-MRNA-SPLICINGFACTOR ATP-DEPENDENTRNA HELICASE PRP43 (Chaetomiumthermophilum) |
PF00270(DEAD)PF00271(Helicase_C)PF04408(HA2)PF07717(OB_NTP_bind) | 3 | SER A 158GLY A 349GLU A 320 | None U E 5 ( 3.7A)None | 0.62A | 4juoA-5ltaA:3.54juoC-5ltaA:2.2 | 4juoA-5ltaA:22.494juoC-5ltaA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mh5 | D-2-HYDROXYACIDDEHYDROGENASE (Haloferaxmediterranei) |
no annotation | 3 | SER A 261GLY A 227GLU A 71 | None | 0.62A | 4juoA-5mh5A:undetectable4juoC-5mh5A:undetectable | 4juoA-5mh5A:12.504juoC-5mh5A:8.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mog | PHYTOENEDEHYDROGENASE,CHLOROPLASTIC/CHROMOPLASTIC (Oryza sativa) |
PF01593(Amino_oxidase) | 3 | SER A 547GLY A 141GLU A 155 | NoneFAD A 600 (-3.2A)None | 0.61A | 4juoA-5mogA:undetectable4juoC-5mogA:undetectable | 4juoA-5mogA:23.644juoC-5mogA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nc8 | POTASSIUM EFFLUXSYSTEM PROTEIN (Shewanelladenitrificans) |
PF02254(TrkA_N) | 3 | SER A 440GLY A 418GLU A 524 | None | 0.58A | 4juoA-5nc8A:undetectable4juoC-5nc8A:undetectable | 4juoA-5nc8A:20.674juoC-5nc8A:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t4y | SUSC HOMOLOG (Bacteroidesthetaiotaomicron) |
no annotation | 3 | SER D 581GLY D 549GLU D 481 | None | 0.52A | 4juoA-5t4yD:undetectable4juoC-5t4yD:undetectable | 4juoA-5t4yD:19.144juoC-5t4yD:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u6u | CYTOCHROME P450 (Rhodopseudomonaspalustris) |
no annotation | 3 | SER A 95GLY A 360GLU A 367 | 81M A 502 (-2.5A)HEM A 501 (-3.6A)None | 0.56A | 4juoA-5u6uA:undetectable4juoC-5u6uA:undetectable | 4juoA-5u6uA:11.424juoC-5u6uA:7.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v7i | SERINEHYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL (Homo sapiens) |
no annotation | 3 | SER A 417GLY A 175GLU A 191 | None | 0.62A | 4juoA-5v7iA:2.04juoC-5v7iA:undetectable | 4juoA-5v7iA:23.364juoC-5v7iA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v9p | LYSINE-SPECIFICDEMETHYLASE 5A (Homo sapiens) |
PF00628(PHD)PF01388(ARID)PF02373(JmjC)PF02375(JmjN)PF02928(zf-C5HC2)PF08429(PLU-1) | 3 | SER A 420GLY A 442GLU A 452 | None | 0.60A | 4juoA-5v9pA:2.34juoC-5v9pA:undetectable | 4juoA-5v9pA:20.104juoC-5v9pA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vld | HISTIDINOLDEHYDROGENASE,CHLOROPLASTIC (Medicagotruncatula) |
PF00815(Histidinol_dh) | 3 | SER A 426GLY A 387GLU A 384 | None | 0.57A | 4juoA-5vldA:undetectable4juoC-5vldA:undetectable | 4juoA-5vldA:24.434juoC-5vldA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtc | NADH DEHYDROGENASE[UBIQUINONE] 1SUBUNIT C2 (Homo sapiens) |
no annotation | 3 | SER g 40GLY g 71GLU g 78 | None | 0.56A | 4juoA-5xtcg:undetectable4juoC-5xtcg:undetectable | 4juoA-5xtcg:12.904juoC-5xtcg:9.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y10 | MEMBRANEGLYCOPROTEINPOLYPROTEIN (SFTSphlebovirus) |
PF07243(Phlebovirus_G1) | 3 | SER C 45GLY C 282GLU C 293 | None | 0.59A | 4juoA-5y10C:undetectable4juoC-5y10C:undetectable | 4juoA-5y10C:20.524juoC-5y10C:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3x | BETA-XYLANASE (Caldicellulosiruptorowensensis) |
no annotation | 3 | SER A 45GLY A 213GLU A 187 | None | 0.62A | 4juoA-5y3xA:undetectable4juoC-5y3xA:undetectable | 4juoA-5y3xA:10.894juoC-5y3xA:10.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6brs | PUTATIVE ZINCPROTEASE (Pectobacteriumatrosepticum) |
no annotation | 3 | SER A 296GLY A 425GLU A 397 | None | 0.62A | 4juoA-6brsA:1.34juoC-6brsA:2.2 | 4juoA-6brsA:10.474juoC-6brsA:10.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bsz | METABOTROPICGLUTAMATE RECEPTOR 8 (Homo sapiens) |
no annotation | 3 | SER A 308GLY A 225GLU A 256 | None | 0.57A | 4juoA-6bszA:undetectable4juoC-6bszA:3.5 | 4juoA-6bszA:10.164juoC-6bszA:8.75 |