SIMILAR PATTERNS OF AMINO ACIDS FOR 4JQ2_A_SUZA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		5 TYR A  24
TRP A  86
ILE A 129
GLU A 224
TRP A 227
 None
 0.88A 4jq2A-1q5mA:
52.2		 4jq2A-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		6 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ILE A 129
GLU A 224
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
None
 0.38A 4jq2A-1q5mA:
52.2		 4jq2A-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		8 VAL A  54
TYR A  55
TRP A  86
HIS A 117
ILE A 129
HIS A 222
GLU A 224
LEU A 306
 FFA  A 325 (-4.8A)
FFA  A 325 ( 4.3A)
None
FFA  A 325 ( 3.8A)
None
NAP  A   1 ( 4.8A)
None
FFA  A 325 (-4.8A)
 0.57A 4jq2A-2ipjA:
55.7		 4jq2A-2ipjA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		8 VAL A  54
TYR A  55
TRP A  86
HIS A 117
ILE A 129
HIS A 222
TRP A 227
LEU A 306
 FFA  A 325 (-4.8A)
FFA  A 325 ( 4.3A)
None
FFA  A 325 ( 3.8A)
None
NAP  A   1 ( 4.8A)
FFA  A 325 (-3.8A)
FFA  A 325 (-4.8A)
 0.54A 4jq2A-2ipjA:
55.7		 4jq2A-2ipjA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		5 TYR A  24
TYR A  55
TRP A  86
HIS A 117
LEU A 306
 MLY  A  25 (-3.6A)
NAD  A 327 ( 4.7A)
None
MRD  A 328 ( 3.9A)
MRD  A 328 ( 4.3A)
 0.49A 4jq2A-3ln3A:
50.4		 4jq2A-3ln3A:
66.25