SIMILAR PATTERNS OF AMINO ACIDS FOR 4JQ1_B_NPSB401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a88 CHLOROPEROXIDASE L

(Streptomyces
lividans) 		PF00561
(Abhydrolase_1) 		4 VAL A 114
HIS A  92
VAL A 216
ILE A 214
 None
 0.86A 4jq1B-1a88A:
undetectable		 4jq1B-1a88A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A  83
VAL A  73
ILE A  38
LEU A  92
 None
 0.89A 4jq1B-1d1tA:
undetectable		 4jq1B-1d1tA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h76 SEROTRANSFERRIN

(Sus scrofa) 		PF00405
(Transferrin) 		4 TYR A 192
HIS A 253
ILE A  11
LEU A  65
 CO3  A 700 ( 3.8A)
FE  A 702 ( 3.4A)
None
None
 0.83A 4jq1B-1h76A:
undetectable		 4jq1B-1h76A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY

(Thermotoga
maritima) 		PF02829
(3H)
PF08279
(HTH_11) 		4 VAL A  77
HIS A 146
VAL A  75
ILE A 150
 None
NI  A 201 (-3.4A)
None
None
 0.90A 4jq1B-1j5yA:
undetectable		 4jq1B-1j5yA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mum 2-METHYLISOCITRATE
LYASE

(Escherichia
coli) 		PF13714
(PEP_mutase) 		4 VAL A 250
TYR A 251
VAL A 263
ILE A 264
 None
 0.77A 4jq1B-1mumA:
4.1		 4jq1B-1mumA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nex CDC4 PROTEIN

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12937
(F-box-like) 		4 VAL B 301
TRP B 305
ILE B 309
LEU B 290
 None
 0.92A 4jq1B-1nexB:
undetectable		 4jq1B-1nexB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A1083
VAL A1073
ILE A1038
LEU A1092
 None
 0.93A 4jq1B-1p0cA:
undetectable		 4jq1B-1p0cA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn3 GLYCOSYLTRANSFERASE
GTFA

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		4 VAL A 108
TYR A 119
VAL A  86
LEU A  17
 None
 0.92A 4jq1B-1pn3A:
undetectable		 4jq1B-1pn3A:
23.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		5 TYR A  55
TRP A  86
HIS A 117
ILE A 129
TRP A 227
 NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
None
 0.82A 4jq1B-1q5mA:
52.1		 4jq1B-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1

(Caenorhabditis
elegans) 		PF00248
(Aldo_ket_red) 		4 VAL A  51
TYR A  52
TRP A  83
HIS A 114
 None
 0.45A 4jq1B-1qwkA:
40.9		 4jq1B-1qwkA:
39.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz9 REP PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF08724
(Rep_N) 		4 VAL A   7
VAL A 108
ILE A 111
LEU A  64
 None
 0.88A 4jq1B-1rz9A:
undetectable		 4jq1B-1rz9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Arabidopsis
thaliana) 		PF00903
(Glyoxalase) 		5 VAL A 169
TYR A 171
HIS A  27
ILE A  99
LEU A  68
 None
 1.18A 4jq1B-1tg5A:
undetectable		 4jq1B-1tg5A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A  83
VAL A  73
ILE A  38
LEU A  92
 None
 0.90A 4jq1B-1u3tA:
undetectable		 4jq1B-1u3tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Thermotoga
maritima) 		PF01039
(Carboxyl_trans) 		4 VAL A 284
TYR A 282
VAL A 309
ILE A 308
 None
 0.89A 4jq1B-1vrgA:
undetectable		 4jq1B-1vrgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5n HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		4 VAL A  57
VAL A  19
ILE A  93
LEU A  23
 None
 0.93A 4jq1B-1x5nA:
undetectable		 4jq1B-1x5nA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xre SUPEROXIDE DISMUTASE

(Bacillus
anthracis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 VAL A 195
VAL A 102
ILE A 106
LEU A 120
 None
 0.81A 4jq1B-1xreA:
undetectable		 4jq1B-1xreA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7a CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF01522
(Polysacc_deac_1) 		4 HIS A 301
ILE A 293
TRP A  21
LEU A 193
 None
 0.89A 4jq1B-1z7aA:
3.0		 4jq1B-1z7aA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as9 SERINE PROTEASE

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		4 VAL A 102
HIS A  54
VAL A  29
ILE A  35
 None
 0.89A 4jq1B-2as9A:
undetectable		 4jq1B-2as9A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4m GLYCINE
BETAINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		4 VAL A 149
VAL A 187
ILE A 188
LEU A 195
 None
 0.93A 4jq1B-2b4mA:
undetectable		 4jq1B-2b4mA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 VAL A  77
TYR A  78
HIS A 142
TRP A 257
 None
NDP  A1361 (-4.9A)
NDP  A1361 (-3.7A)
None
 0.65A 4jq1B-2clpA:
23.6		 4jq1B-2clpA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 VAL A 475
TYR A 307
VAL A 448
ILE A 465
 None
 0.83A 4jq1B-2d3tA:
2.2		 4jq1B-2d3tA:
18.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 TYR A  55
TRP A  86
HIS A 117
TRP A 227
 NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
 0.67A 4jq1B-2fvlA:
51.9		 4jq1B-2fvlA:
81.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9d SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio cholerae) 		PF04952
(AstE_AspA) 		4 VAL A  44
VAL A  87
ILE A 245
LEU A  73
 None
 0.85A 4jq1B-2g9dA:
undetectable		 4jq1B-2g9dA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqf HYPOTHETICAL PROTEIN
HI0933

(Haemophilus
influenzae) 		PF03486
(HI0933_like) 		4 TYR A 201
VAL A 244
ILE A 220
LEU A 261
 None
 0.92A 4jq1B-2gqfA:
undetectable		 4jq1B-2gqfA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr7 INSULIN RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 VAL A 117
TRP A 133
ILE A 136
LEU A 106
 None
 0.92A 4jq1B-2hr7A:
undetectable		 4jq1B-2hr7A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5i UPF0249 PROTEIN
EF_3048

(Enterococcus
faecalis) 		PF04794
(YdjC) 		4 TYR A 227
VAL A  19
ILE A  23
LEU A 238
 None
 0.83A 4jq1B-2i5iA:
2.9		 4jq1B-2i5iA:
24.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipf (3(17)ALPHA-HYDROXYS
TEROID
DEHYDROGENASE)

(Mus musculus) 		PF00248
(Aldo_ket_red) 		5 VAL A  54
TYR A  55
TRP A  86
HIS A 117
TRP A 227
 None
FFA  A   3 ( 4.5A)
None
FFA  A   3 ( 4.1A)
FFA  A   3 (-4.0A)
 0.68A 4jq1B-2ipfA:
51.3		 4jq1B-2ipfA:
72.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 VAL A  54
TYR A  55
HIS A 117
TRP A 227
LEU A 306
 FFA  A 325 (-4.8A)
FFA  A 325 ( 4.3A)
FFA  A 325 ( 3.8A)
FFA  A 325 (-3.8A)
FFA  A 325 (-4.8A)
 1.49A 4jq1B-2ipjA:
54.5		 4jq1B-2ipjA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		8 VAL A  54
TYR A  55
TRP A  86
HIS A 117
VAL A 128
ILE A 129
TRP A 227
LEU A 308
 FFA  A 325 (-4.8A)
FFA  A 325 ( 4.3A)
None
FFA  A 325 ( 3.8A)
None
None
FFA  A 325 (-3.8A)
FFA  A 325 (-4.5A)
 0.46A 4jq1B-2ipjA:
54.5		 4jq1B-2ipjA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2is7 ALDOSE REDUCTASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 VAL A  47
TYR A  48
TRP A  79
HIS A 110
 2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
None
2CL  A 317 ( 3.8A)
 0.43A 4jq1B-2is7A:
46.5		 4jq1B-2is7A:
49.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyk M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		5 VAL A 123
TYR A 125
HIS A 116
VAL A 121
LEU A  86
 None
 1.48A 4jq1B-2nykA:
undetectable		 4jq1B-2nykA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		4 VAL A 107
VAL A  83
ILE A  82
LEU A  26
 None
 0.80A 4jq1B-2owzA:
undetectable		 4jq1B-2owzA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p62 HYPOTHETICAL PROTEIN
PH0156

(Pyrococcus
horikoshii) 		PF11536
(DUF3226) 		4 VAL A  95
TYR A 134
ILE A  62
LEU A  20
 None
 0.91A 4jq1B-2p62A:
undetectable		 4jq1B-2p62A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph7 UNCHARACTERIZED
PROTEIN AF_2093

(Archaeoglobus
fulgidus) 		no annotation 4 VAL A 168
TRP A 199
ILE A 208
LEU A 220
 None
 0.87A 4jq1B-2ph7A:
undetectable		 4jq1B-2ph7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 VAL A 375
VAL A 291
ILE A 292
LEU A 299
 None
 0.74A 4jq1B-2r6fA:
undetectable		 4jq1B-2r6fA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rui LPXTG-SITE
TRANSPEPTIDASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF04203
(Sortase) 		5 VAL A 199
TYR A 197
VAL A 160
ILE A 147
LEU A  90
 None
 1.45A 4jq1B-2ruiA:
undetectable		 4jq1B-2ruiA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vid SERINE PROTEASE SPLB

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		4 VAL A 101
HIS A  53
VAL A  28
ILE A  34
 None
 0.88A 4jq1B-2vidA:
undetectable		 4jq1B-2vidA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 TYR A 202
ILE A 206
TRP A 264
LEU A 250
 None
MGD  A1766 (-4.6A)
None
None
 0.94A 4jq1B-2vpwA:
undetectable		 4jq1B-2vpwA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 VAL A 636
TRP A 692
ILE A 448
LEU A 512
 None
 0.92A 4jq1B-2vxoA:
undetectable		 4jq1B-2vxoA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG

(Escherichia
coli) 		PF13483
(Lactamase_B_3) 		5 VAL A 113
VAL A 131
ILE A 107
TRP A  49
LEU A  43
 None
None
GOL  A1343 (-3.9A)
GOL  A1343 ( 4.9A)
None
 1.19A 4jq1B-2wymA:
undetectable		 4jq1B-2wymA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 4 VAL A  95
VAL A  61
ILE A  64
LEU A  73
 None
 0.92A 4jq1B-2xecA:
2.2		 4jq1B-2xecA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 VAL A 212
VAL A 151
ILE A 232
LEU A 244
 None
 0.84A 4jq1B-2yijA:
undetectable		 4jq1B-2yijA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 VAL X 701
VAL X 684
ILE X 793
LEU X 769
 None
 0.91A 4jq1B-2zkmX:
7.6		 4jq1B-2zkmX:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0r SENSOR PROTEIN

(Thermotoga
maritima) 		PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c) 		4 VAL A 475
VAL A 512
ILE A 514
LEU A 484
 None
 0.83A 4jq1B-3a0rA:
undetectable		 4jq1B-3a0rA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0v SENSOR PROTEIN

(Thermotoga
maritima) 		PF00989
(PAS) 		4 VAL A 475
VAL A 512
ILE A 514
LEU A 484
 None
EOH  A 101 ( 4.7A)
None
None
 0.92A 4jq1B-3a0vA:
undetectable		 4jq1B-3a0vA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv6 METAL-DEPENDENT
HYDROLASE

(Vibrio cholerae) 		PF13483
(Lactamase_B_3) 		5 VAL A 113
VAL A 131
ILE A 107
TRP A  49
LEU A  43
 None
 1.21A 4jq1B-3bv6A:
undetectable		 4jq1B-3bv6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens) 		PF01522
(Polysacc_deac_1) 		4 HIS A 301
ILE A 293
TRP A  21
LEU A 193
 None
 0.84A 4jq1B-3cl6A:
2.9		 4jq1B-3cl6A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB

(Escherichia
coli) 		PF04449
(Fimbrial_CS1)
PF07434
(CblD) 		4 VAL A 446
VAL A 503
ILE A 520
LEU A 381
 None
 0.90A 4jq1B-3f83A:
undetectable		 4jq1B-3f83A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f84 CFA/I FIMBRIAL
SUBUNIT B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		4 VAL A  69
VAL A 126
ILE A 143
LEU A   4
 None
 0.90A 4jq1B-3f84A:
undetectable		 4jq1B-3f84A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f84 CFA/I FIMBRIAL
SUBUNIT B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		4 VAL A 220
VAL A 277
ILE A 294
LEU A 155
 None
 0.93A 4jq1B-3f84A:
undetectable		 4jq1B-3f84A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		4 VAL A  69
VAL A 126
ILE A 143
LEU A   4
 None
 0.89A 4jq1B-3f85A:
undetectable		 4jq1B-3f85A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		4 VAL A 220
VAL A 277
ILE A 294
LEU A 155
 None
 0.88A 4jq1B-3f85A:
undetectable		 4jq1B-3f85A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		4 VAL A 371
VAL A 428
ILE A 445
LEU A 306
 None
 0.92A 4jq1B-3f85A:
undetectable		 4jq1B-3f85A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		4 VAL A  90
VAL A 104
ILE A 105
LEU A 112
 None
 0.88A 4jq1B-3gs3A:
undetectable		 4jq1B-3gs3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF01030
(Recep_L_domain) 		4 VAL A 131
TRP A 147
ILE A 150
LEU A 120
 None
 0.92A 4jq1B-3h3bA:
undetectable		 4jq1B-3h3bA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 VAL A 108
TYR A 119
VAL A  86
LEU A  17
 None
 0.91A 4jq1B-3h4iA:
undetectable		 4jq1B-3h4iA:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		4 TYR A  52
TRP A  83
HIS A 114
ILE A 126
 ACT  A 501 ( 4.4A)
None
ACT  A 501 ( 3.8A)
None
 0.86A 4jq1B-3h7uA:
41.5		 4jq1B-3h7uA:
40.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 VAL A 393
VAL A 467
ILE A 465
LEU A 386
 None
 0.93A 4jq1B-3hwwA:
undetectable		 4jq1B-3hwwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihw CENTG3

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 245
VAL A  94
ILE A 142
LEU A 107
 None
 0.80A 4jq1B-3ihwA:
2.9		 4jq1B-3ihwA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00067
(p450) 		4 TRP A 210
VAL A 182
ILE A 179
LEU A 472
 None
 0.88A 4jq1B-3k9yA:
undetectable		 4jq1B-3k9yA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kom TRANSKETOLASE

(Francisella
tularensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 VAL A 181
TYR A 152
HIS A 234
ILE A 215
 None
 0.82A 4jq1B-3komA:
undetectable		 4jq1B-3komA:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		4 VAL A  39
TYR A  40
TRP A  73
HIS A 104
 None
UNX  A 402 (-4.4A)
None
UNX  A 402 (-4.1A)
 0.48A 4jq1B-3krbA:
39.0		 4jq1B-3krbA:
35.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 TYR A 285
VAL A 333
ILE A 315
LEU A 309
 None
 0.84A 4jq1B-3krtA:
undetectable		 4jq1B-3krtA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 TYR A  55
TRP A  86
HIS A 117
TRP A 227
 NAD  A 327 ( 4.7A)
None
MRD  A 328 ( 3.9A)
MRD  A 328 (-4.0A)
 0.68A 4jq1B-3ln3A:
50.4		 4jq1B-3ln3A:
66.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Pectobacterium
atrosepticum) 		PF00155
(Aminotran_1_2) 		4 VAL A 266
TYR A 264
HIS A 104
ILE A 245
 None
EDO  A   2 (-4.8A)
None
None
 0.73A 4jq1B-3ly1A:
undetectable		 4jq1B-3ly1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2t PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		4 VAL A  58
TYR A  59
HIS A 130
VAL A  99
 None
 0.79A 4jq1B-3n2tA:
26.7		 4jq1B-3n2tA:
26.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		4 VAL A  48
TYR A  49
TRP A  80
HIS A 111
 None
NAP  A 317 (-4.9A)
None
NAP  A 317 (-4.3A)
 0.16A 4jq1B-3o3rA:
45.1		 4jq1B-3o3rA:
46.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ory FLAP ENDONUCLEASE 1

(Desulfurococcus
amylolyticus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 VAL A 165
VAL A  29
ILE A  28
LEU A 213
 None
 0.73A 4jq1B-3oryA:
undetectable		 4jq1B-3oryA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 VAL A 128
TRP A 144
ILE A 147
LEU A 117
 None
 0.93A 4jq1B-3p11A:
undetectable		 4jq1B-3p11A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR

(Ancylostoma
ceylanicum) 		PF01187
(MIF) 		4 VAL A  61
TYR A  98
ILE A  37
LEU A  25
 None
 0.70A 4jq1B-3rf5A:
undetectable		 4jq1B-3rf5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc4 SHORT CHAIN
DEHYDROGENASE
(A0QTM2 HOMOLOG)

(Mycolicibacterium
thermoresistibile) 		PF00106
(adh_short) 		4 VAL A  25
VAL A  32
ILE A  10
LEU A 144
 None
 0.93A 4jq1B-3sc4A:
undetectable		 4jq1B-3sc4A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 VAL A 191
VAL A 234
ILE A 235
TRP A 272
 None
 0.94A 4jq1B-3sm9A:
undetectable		 4jq1B-3sm9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdq PILY2 PROTEIN

(Pseudomonas
aeruginosa) 		PF14481
(Fimbrial_PilY2) 		4 VAL A  30
VAL A  70
ILE A  86
LEU A  61
 None
None
GOL  A 119 (-4.7A)
None
 0.92A 4jq1B-3tdqA:
undetectable		 4jq1B-3tdqA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 VAL A 320
VAL A 352
ILE A 356
LEU A 470
 None
 0.90A 4jq1B-3tk3A:
undetectable		 4jq1B-3tk3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 VAL A 122
TRP A 138
ILE A 141
LEU A 111
 None
 0.94A 4jq1B-3u2pA:
undetectable		 4jq1B-3u2pA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 VAL A 122
TRP A 138
ILE A 141
LEU A 111
 None
 0.94A 4jq1B-3u7uA:
undetectable		 4jq1B-3u7uA:
18.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wcz ALDO-KETO REDUCTASE
2E

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		4 VAL A  57
TYR A  58
TRP A  89
HIS A 120
 None
CIT  A 406 ( 3.2A)
None
NAP  A 401 (-4.0A)
 0.46A 4jq1B-3wczA:
42.7		 4jq1B-3wczA:
42.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 4 VAL B 521
HIS B 511
VAL B 161
ILE B 154
 None
 0.93A 4jq1B-3x17B:
undetectable		 4jq1B-3x17B:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE

(Pyrococcus
abyssi) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		4 TYR A 180
VAL A 147
ILE A 154
LEU A 139
 None
 0.61A 4jq1B-4a8eA:
undetectable		 4jq1B-4a8eA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e09 PLASMID PARTITIONING
PROTEIN PARF

(Escherichia
coli) 		PF01656
(CbiA) 		4 VAL A  66
TYR A  67
VAL A  36
LEU A   7
 None
 0.94A 4jq1B-4e09A:
2.1		 4jq1B-4e09A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbv MYXOBACTERIAL
HEMAGGLUTININ

(Myxococcus
xanthus) 		no annotation 4 TYR A   4
VAL A 103
ILE A  38
TRP A  90
 None
 0.71A 4jq1B-4fbvA:
undetectable		 4jq1B-4fbvA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1g MATRIX PROTEIN

(Avian
avulavirus 1) 		PF00661
(Matrix) 		4 TYR A 302
VAL A 325
ILE A 350
LEU A 264
 None
 0.83A 4jq1B-4g1gA:
undetectable		 4jq1B-4g1gA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis) 		no annotation 4 TYR A 212
VAL A 177
ILE A 246
TRP A 165
 None
 0.65A 4jq1B-4gk9A:
undetectable		 4jq1B-4gk9A:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)

(Schistosoma
japonicum) 		PF00248
(Aldo_ket_red) 		5 VAL A  47
TYR A  48
TRP A  79
HIS A 110
LEU A 295
 None
 0.90A 4jq1B-4hbkA:
43.7		 4jq1B-4hbkA:
40.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi5 MATRIX PROTEIN

(Borna disease
virus) 		PF16520
(BDV_M) 		4 VAL A  92
VAL A  16
ILE A  15
LEU A  22
 None
 0.88A 4jq1B-4hi5A:
undetectable		 4jq1B-4hi5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hji CS1 FIMBRIAL SUBUNIT
A

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		4 VAL A  82
VAL A 140
ILE A 157
LEU A  17
 None
 0.86A 4jq1B-4hjiA:
undetectable		 4jq1B-4hjiA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io6 AVGLUR1 LIGAND
BINDING DOMAIN

(Adineta vaga) 		PF00497
(SBP_bac_3) 		4 VAL A  41
TYR A  40
VAL A  14
ILE A  15
 None
 0.84A 4jq1B-4io6A:
undetectable		 4jq1B-4io6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 VAL A 146
TYR A 145
VAL A 156
ILE A 158
LEU A  93
 None
 1.38A 4jq1B-4j0mA:
undetectable		 4jq1B-4j0mA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb3 HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		4 VAL A 170
VAL A  12
ILE A  13
LEU A  98
 None
 0.93A 4jq1B-4jb3A:
undetectable		 4jq1B-4jb3A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n40 PROTEIN ECT2

(Homo sapiens) 		PF00533
(BRCT)
PF12738
(PTCB-BRCT) 		4 VAL A  53
VAL A  74
ILE A  72
LEU A 124
 None
 0.93A 4jq1B-4n40A:
undetectable		 4jq1B-4n40A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf1 ACETYLGLUTAMATE
KINASE

(Xylella
fastidiosa) 		PF04768
(NAT) 		4 VAL A 371
VAL A 293
ILE A 294
LEU A 307
 None
 0.92A 4jq1B-4nf1A:
undetectable		 4jq1B-4nf1A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7i 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00459
(Inositol_P) 		4 VAL A 148
VAL A  14
ILE A  13
TRP A 115
 None
 0.86A 4jq1B-4o7iA:
undetectable		 4jq1B-4o7iA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH1

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N) 		4 VAL A 130
VAL A  11
ILE A  14
LEU A  87
 None
 0.90A 4jq1B-4w78A:
undetectable		 4jq1B-4w78A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydo UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF00432
(Prenyltrans) 		4 TYR B 271
VAL B 224
ILE B 227
LEU B 263
 None
 0.93A 4jq1B-4ydoB:
undetectable		 4jq1B-4ydoB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Helicobacter
pylori) 		PF00793
(DAHP_synth_1) 		4 VAL A 120
VAL A 127
ILE A 129
LEU A 110
 None
 0.89A 4jq1B-4z1aA:
6.9		 4jq1B-4z1aA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 HIS A 977
VAL A 817
ILE A 816
LEU A 731
 None
 0.88A 4jq1B-4zdnA:
undetectable		 4jq1B-4zdnA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zvi DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 TYR A 360
HIS A 237
VAL A 372
ILE A 375
LEU A 319
 None
 1.17A 4jq1B-4zviA:
undetectable		 4jq1B-4zviA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 4 VAL A 393
VAL A 407
ILE A 406
LEU A 167
 None
 0.87A 4jq1B-5aa6A:
undetectable		 4jq1B-5aa6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Streptococcus
pneumoniae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 VAL A   9
VAL A 293
ILE A 298
LEU A 308
 None
 0.87A 4jq1B-5bqsA:
undetectable		 4jq1B-5bqsA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czf PLASMID
STABILIZATION
PROTEIN PARE

(Escherichia
coli) 		PF05016
(ParE_toxin) 		4 VAL C  40
VAL C   4
TRP C  33
LEU C  14
 None
 0.86A 4jq1B-5czfC:
undetectable		 4jq1B-5czfC:
19.31